-- dump date 20140619_162307 -- class Genbank::misc_feature -- table misc_feature_note -- id note 479431000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 479431000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479431000004 Walker A motif; other site 479431000005 ATP binding site [chemical binding]; other site 479431000006 Walker B motif; other site 479431000007 arginine finger; other site 479431000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 479431000009 DnaA box-binding interface [nucleotide binding]; other site 479431000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 479431000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 479431000012 putative DNA binding surface [nucleotide binding]; other site 479431000013 dimer interface [polypeptide binding]; other site 479431000014 beta-clamp/clamp loader binding surface; other site 479431000015 beta-clamp/translesion DNA polymerase binding surface; other site 479431000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 479431000017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479431000018 recombination protein F; Reviewed; Region: recF; PRK00064 479431000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 479431000020 Walker A/P-loop; other site 479431000021 ATP binding site [chemical binding]; other site 479431000022 Q-loop/lid; other site 479431000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431000024 ABC transporter signature motif; other site 479431000025 Walker B; other site 479431000026 D-loop; other site 479431000027 H-loop/switch region; other site 479431000028 Protein of unknown function (DUF721); Region: DUF721; cl02324 479431000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 479431000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431000031 Mg2+ binding site [ion binding]; other site 479431000032 G-X-G motif; other site 479431000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 479431000034 anchoring element; other site 479431000035 dimer interface [polypeptide binding]; other site 479431000036 ATP binding site [chemical binding]; other site 479431000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 479431000038 active site 479431000039 putative metal-binding site [ion binding]; other site 479431000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 479431000041 DNA gyrase subunit A; Validated; Region: PRK05560 479431000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 479431000043 CAP-like domain; other site 479431000044 active site 479431000045 primary dimer interface [polypeptide binding]; other site 479431000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479431000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479431000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479431000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479431000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479431000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479431000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 479431000053 bile acid transporter; Region: bass; TIGR00841 479431000054 Sodium Bile acid symporter family; Region: SBF; pfam01758 479431000055 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 479431000056 substrate binding site [chemical binding]; other site 479431000057 dimer interface [polypeptide binding]; other site 479431000058 catalytic triad [active] 479431000059 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 479431000060 Ribulose bisphosphate carboxylase like proteins, Rubisco-Form IV; Region: RuBisCO_IV_RLP; cd08205 479431000061 dimer interface [polypeptide binding]; other site 479431000062 active site 479431000063 catalytic residue [active] 479431000064 metal binding site [ion binding]; metal-binding site 479431000065 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 479431000066 catalytic triad [active] 479431000067 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 479431000068 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 479431000069 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 479431000070 Amidase; Region: Amidase; cl11426 479431000071 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479431000072 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 479431000073 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 479431000074 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 479431000075 Asp-box motif; other site 479431000076 Ubiquitin-like proteins; Region: UBQ; cl00155 479431000077 Membrane transport protein; Region: Mem_trans; cl09117 479431000078 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479431000079 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 479431000080 homodimer interface [polypeptide binding]; other site 479431000081 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 479431000082 active site pocket [active] 479431000083 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 479431000084 ligand binding site [chemical binding]; other site 479431000085 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 479431000086 acyl-CoA synthetase; Validated; Region: PRK08162 479431000087 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 479431000088 acyl-activating enzyme (AAE) consensus motif; other site 479431000089 putative active site [active] 479431000090 AMP binding site [chemical binding]; other site 479431000091 putative CoA binding site [chemical binding]; other site 479431000092 acyl-coenzyme A oxidase; Region: PLN02526 479431000093 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431000094 active site 479431000095 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431000096 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 479431000097 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479431000098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431000099 putative substrate translocation pore; other site 479431000100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431000101 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431000102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431000104 dimer interface [polypeptide binding]; other site 479431000105 phosphorylation site [posttranslational modification] 479431000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431000107 ATP binding site [chemical binding]; other site 479431000108 Mg2+ binding site [ion binding]; other site 479431000109 G-X-G motif; other site 479431000110 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431000111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431000112 active site 479431000113 phosphorylation site [posttranslational modification] 479431000114 intermolecular recognition site; other site 479431000115 dimerization interface [polypeptide binding]; other site 479431000116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431000117 DNA binding site [nucleotide binding] 479431000118 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 479431000119 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431000120 active site 479431000121 urocanate hydratase; Provisional; Region: PRK05414 479431000122 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 479431000123 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 479431000124 Multicopper oxidase; Region: Cu-oxidase; pfam00394 479431000125 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 479431000126 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479431000127 FAD binding domain; Region: FAD_binding_4; pfam01565 479431000128 Berberine and berberine like; Region: BBE; pfam08031 479431000129 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 479431000130 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 479431000131 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431000132 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 479431000133 CoA-transferase family III; Region: CoA_transf_3; pfam02515 479431000134 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 479431000135 active site 479431000136 citrylCoA binding site [chemical binding]; other site 479431000137 oxalacetate binding site [chemical binding]; other site 479431000138 coenzyme A binding site [chemical binding]; other site 479431000139 catalytic triad [active] 479431000140 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 479431000141 active site 479431000142 Fe(II) binding site [ion binding]; other site 479431000143 dimer interface [polypeptide binding]; other site 479431000144 tetramer interface [polypeptide binding]; other site 479431000145 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 479431000146 dimer interface [polypeptide binding]; other site 479431000147 tetramer interface [polypeptide binding]; other site 479431000148 hypothetical protein; Provisional; Region: PRK08204 479431000149 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431000150 active site 479431000151 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431000152 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479431000153 NAD(P) binding site [chemical binding]; other site 479431000154 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 479431000155 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 479431000156 putative active site [active] 479431000157 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 479431000158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431000159 ATP binding site [chemical binding]; other site 479431000160 putative Mg++ binding site [ion binding]; other site 479431000161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431000162 nucleotide binding region [chemical binding]; other site 479431000163 ATP-binding site [chemical binding]; other site 479431000164 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 479431000165 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 479431000166 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 479431000167 active site 479431000168 P-loop; other site 479431000169 phosphorylation site [posttranslational modification] 479431000170 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 479431000171 active site 479431000172 phosphorylation site [posttranslational modification] 479431000173 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 479431000174 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 479431000175 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 479431000176 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 479431000177 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 479431000178 active site 479431000179 ADP/pyrophosphate binding site [chemical binding]; other site 479431000180 dimerization interface [polypeptide binding]; other site 479431000181 allosteric effector site; other site 479431000182 fructose-1,6-bisphosphate binding site; other site 479431000183 AAA ATPase domain; Region: AAA_16; pfam13191 479431000184 endonuclease IV; Provisional; Region: PRK01060 479431000185 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 479431000186 AP (apurinic/apyrimidinic) site pocket; other site 479431000187 DNA interaction; other site 479431000188 Metal-binding active site; metal-binding site 479431000189 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479431000190 nudix motif; other site 479431000191 Cation efflux family; Region: Cation_efflux; pfam01545 479431000192 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 479431000193 metal binding site 2 [ion binding]; metal-binding site 479431000194 putative DNA binding helix; other site 479431000195 metal binding site 1 [ion binding]; metal-binding site 479431000196 dimer interface [polypeptide binding]; other site 479431000197 structural Zn2+ binding site [ion binding]; other site 479431000198 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 479431000199 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 479431000200 active site 479431000201 Rhomboid family; Region: Rhomboid; pfam01694 479431000202 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 479431000203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 479431000204 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 479431000205 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 479431000206 active site 479431000207 catalytic site [active] 479431000208 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 479431000209 Glutamine amidotransferase class-I; Region: GATase; pfam00117 479431000210 glutamine binding [chemical binding]; other site 479431000211 catalytic triad [active] 479431000212 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479431000213 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431000214 active site 479431000215 ATP binding site [chemical binding]; other site 479431000216 substrate binding site [chemical binding]; other site 479431000217 activation loop (A-loop); other site 479431000218 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431000219 PASTA domain; Region: PASTA; pfam03793 479431000220 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431000221 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431000222 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431000223 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431000224 active site 479431000225 ATP binding site [chemical binding]; other site 479431000226 substrate binding site [chemical binding]; other site 479431000227 activation loop (A-loop); other site 479431000228 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 479431000229 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 479431000230 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 479431000231 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 479431000232 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 479431000233 active site 479431000234 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 479431000235 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479431000236 phosphopeptide binding site; other site 479431000237 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 479431000238 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 479431000239 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479431000240 phosphopeptide binding site; other site 479431000241 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 479431000242 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 479431000243 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 479431000244 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431000245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431000246 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431000247 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 479431000248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431000249 NAD(P) binding site [chemical binding]; other site 479431000250 active site 479431000251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431000252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431000253 WHG domain; Region: WHG; pfam13305 479431000254 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479431000255 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 479431000256 Divergent AAA domain; Region: AAA_4; pfam04326 479431000257 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 479431000258 HTH domain; Region: HTH_11; pfam08279 479431000259 WYL domain; Region: WYL; pfam13280 479431000260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431000261 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479431000262 Walker A/P-loop; other site 479431000263 ATP binding site [chemical binding]; other site 479431000264 Q-loop/lid; other site 479431000265 ABC transporter signature motif; other site 479431000266 Walker B; other site 479431000267 D-loop; other site 479431000268 H-loop/switch region; other site 479431000269 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479431000270 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479431000271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431000272 NAD(P) binding site [chemical binding]; other site 479431000273 active site 479431000274 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 479431000275 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 479431000276 Pirin-related protein [General function prediction only]; Region: COG1741 479431000277 Pirin; Region: Pirin; pfam02678 479431000278 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 479431000279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431000280 dimerization interface [polypeptide binding]; other site 479431000281 putative DNA binding site [nucleotide binding]; other site 479431000282 putative Zn2+ binding site [ion binding]; other site 479431000283 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479431000284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431000285 S-adenosylmethionine binding site [chemical binding]; other site 479431000286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431000287 dimerization interface [polypeptide binding]; other site 479431000288 putative DNA binding site [nucleotide binding]; other site 479431000289 putative Zn2+ binding site [ion binding]; other site 479431000290 Low molecular weight phosphatase family; Region: LMWPc; cl00105 479431000291 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 479431000292 active site 479431000293 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 479431000294 Low molecular weight phosphatase family; Region: LMWPc; cd00115 479431000295 active site 479431000296 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 479431000297 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 479431000298 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 479431000299 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479431000300 Part of AAA domain; Region: AAA_19; pfam13245 479431000301 Family description; Region: UvrD_C_2; pfam13538 479431000302 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431000303 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 479431000304 NAD(P) binding site [chemical binding]; other site 479431000305 Transposase domain (DUF772); Region: DUF772; pfam05598 479431000306 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431000307 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431000308 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479431000309 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431000310 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 479431000311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431000312 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479431000313 Short C-terminal domain; Region: SHOCT; pfam09851 479431000314 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 479431000315 metal-binding site [ion binding] 479431000316 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 479431000317 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 479431000318 active site 479431000319 Zn binding site [ion binding]; other site 479431000320 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431000321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431000322 metal binding site [ion binding]; metal-binding site 479431000323 active site 479431000324 I-site; other site 479431000325 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 479431000326 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 479431000327 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479431000328 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 479431000329 putative metal binding site [ion binding]; other site 479431000330 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 479431000331 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 479431000332 Spore germination protein; Region: Spore_permease; cl17796 479431000333 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 479431000334 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 479431000335 active site 479431000336 ADP/pyrophosphate binding site [chemical binding]; other site 479431000337 dimerization interface [polypeptide binding]; other site 479431000338 allosteric effector site; other site 479431000339 fructose-1,6-bisphosphate binding site; other site 479431000340 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 479431000341 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 479431000342 putative dimer interface [polypeptide binding]; other site 479431000343 N-terminal domain interface [polypeptide binding]; other site 479431000344 putative substrate binding pocket (H-site) [chemical binding]; other site 479431000345 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479431000346 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 479431000347 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 479431000348 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 479431000349 putative DNA binding site [nucleotide binding]; other site 479431000350 putative homodimer interface [polypeptide binding]; other site 479431000351 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 479431000352 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 479431000353 nucleotide binding site [chemical binding]; other site 479431000354 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 479431000355 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 479431000356 active site 479431000357 DNA binding site [nucleotide binding] 479431000358 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 479431000359 DNA binding site [nucleotide binding] 479431000360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 479431000361 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 479431000362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431000363 Transposase; Region: HTH_Tnp_1; cl17663 479431000364 putative transposase OrfB; Reviewed; Region: PHA02517 479431000365 HTH-like domain; Region: HTH_21; pfam13276 479431000366 Integrase core domain; Region: rve; pfam00665 479431000367 Integrase core domain; Region: rve_3; cl15866 479431000368 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 479431000369 putative hydrophobic ligand binding site [chemical binding]; other site 479431000370 hypothetical protein; Provisional; Region: PRK07588 479431000371 hypothetical protein; Provisional; Region: PRK07236 479431000372 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 479431000373 putative dimer interface [polypeptide binding]; other site 479431000374 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431000375 cobyric acid synthase; Provisional; Region: PRK00784 479431000376 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 479431000377 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 479431000378 catalytic triad [active] 479431000379 Domain of unknown function (DUF305); Region: DUF305; pfam03713 479431000380 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 479431000381 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 479431000382 active site 479431000383 SAM binding site [chemical binding]; other site 479431000384 homodimer interface [polypeptide binding]; other site 479431000385 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479431000386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431000387 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431000388 MarR family; Region: MarR; pfam01047 479431000389 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 479431000390 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 479431000391 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 479431000392 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479431000393 active site 479431000394 ATP binding site [chemical binding]; other site 479431000395 substrate binding site [chemical binding]; other site 479431000396 activation loop (A-loop); other site 479431000397 Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709 479431000398 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 479431000399 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479431000400 nudix motif; other site 479431000401 precorrin-3B synthase; Region: CobG; TIGR02435 479431000402 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 479431000403 Precorrin-8X methylmutase; Region: CbiC; pfam02570 479431000404 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 479431000405 active site 479431000406 SAM binding site [chemical binding]; other site 479431000407 homodimer interface [polypeptide binding]; other site 479431000408 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 479431000409 homodimer interface [polypeptide binding]; other site 479431000410 active site 479431000411 SAM binding site [chemical binding]; other site 479431000412 Domain of unknown function (DUF202); Region: DUF202; cl09954 479431000413 Domain of unknown function (DUF202); Region: DUF202; pfam02656 479431000414 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 479431000415 active site 479431000416 homodimer interface [polypeptide binding]; other site 479431000417 SAM binding site [chemical binding]; other site 479431000418 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 479431000419 putative homodimer interface [polypeptide binding]; other site 479431000420 active site 479431000421 SAM binding site [chemical binding]; other site 479431000422 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 479431000423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479431000424 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 479431000425 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 479431000426 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 479431000427 metal ion-dependent adhesion site (MIDAS); other site 479431000428 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 479431000429 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 479431000430 homodimer interface [polypeptide binding]; other site 479431000431 Walker A motif; other site 479431000432 ATP binding site [chemical binding]; other site 479431000433 hydroxycobalamin binding site [chemical binding]; other site 479431000434 Walker B motif; other site 479431000435 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 479431000436 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 479431000437 catalytic triad [active] 479431000438 hypothetical protein; Provisional; Region: PRK07908 479431000439 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431000440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431000441 homodimer interface [polypeptide binding]; other site 479431000442 catalytic residue [active] 479431000443 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 479431000444 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 479431000445 active site 479431000446 SAM binding site [chemical binding]; other site 479431000447 homodimer interface [polypeptide binding]; other site 479431000448 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 479431000449 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 479431000450 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 479431000451 putative dimer interface [polypeptide binding]; other site 479431000452 active site pocket [active] 479431000453 putative cataytic base [active] 479431000454 cobalamin synthase; Reviewed; Region: cobS; PRK00235 479431000455 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 479431000456 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 479431000457 TIGR02680 family protein; Region: TIGR02680 479431000458 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 479431000459 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 479431000460 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 479431000461 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 479431000462 homotrimer interface [polypeptide binding]; other site 479431000463 Walker A motif; other site 479431000464 GTP binding site [chemical binding]; other site 479431000465 Walker B motif; other site 479431000466 Amidohydrolase; Region: Amidohydro_2; pfam04909 479431000467 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 479431000468 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 479431000469 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 479431000470 Domain of unknown function (DUF427); Region: DUF427; pfam04248 479431000471 Domain of unknown function (DUF427); Region: DUF427; cl00998 479431000472 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 479431000473 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 479431000474 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 479431000475 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 479431000476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431000477 catalytic residue [active] 479431000478 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 479431000479 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 479431000480 putative dimer interface [polypeptide binding]; other site 479431000481 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 479431000482 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479431000483 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479431000484 xylose isomerase; Provisional; Region: PRK12677 479431000485 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 479431000486 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431000487 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431000488 DNA binding site [nucleotide binding] 479431000489 domain linker motif; other site 479431000490 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431000491 dimerization interface [polypeptide binding]; other site 479431000492 ligand binding site [chemical binding]; other site 479431000493 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479431000494 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479431000495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431000496 dimer interface [polypeptide binding]; other site 479431000497 conserved gate region; other site 479431000498 putative PBP binding loops; other site 479431000499 ABC-ATPase subunit interface; other site 479431000500 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479431000501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431000502 dimer interface [polypeptide binding]; other site 479431000503 conserved gate region; other site 479431000504 putative PBP binding loops; other site 479431000505 ABC-ATPase subunit interface; other site 479431000506 putative alpha-glucosidase; Provisional; Region: PRK10658 479431000507 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 479431000508 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 479431000509 active site 479431000510 homotrimer interface [polypeptide binding]; other site 479431000511 catalytic site [active] 479431000512 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 479431000513 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 479431000514 beta-galactosidase; Region: BGL; TIGR03356 479431000515 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479431000516 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 479431000517 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 479431000518 FAD binding domain; Region: FAD_binding_2; pfam00890 479431000519 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431000520 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431000521 metal binding site [ion binding]; metal-binding site 479431000522 active site 479431000523 I-site; other site 479431000524 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431000525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431000526 metal binding site [ion binding]; metal-binding site 479431000527 active site 479431000528 I-site; other site 479431000529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431000530 Coenzyme A binding pocket [chemical binding]; other site 479431000531 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 479431000532 Domain of unknown function DUF20; Region: UPF0118; pfam01594 479431000533 short chain dehydrogenase; Provisional; Region: PRK05854 479431000534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431000535 NAD(P) binding site [chemical binding]; other site 479431000536 active site 479431000537 CopC domain; Region: CopC; pfam04234 479431000538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431000539 NAD(P) binding site [chemical binding]; other site 479431000540 active site 479431000541 Proline dehydrogenase; Region: Pro_dh; cl03282 479431000542 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479431000543 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 479431000544 NAD(P) binding site [chemical binding]; other site 479431000545 catalytic residues [active] 479431000546 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 479431000547 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431000548 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431000549 metal binding site [ion binding]; metal-binding site 479431000550 active site 479431000551 I-site; other site 479431000552 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 479431000553 hypothetical protein; Provisional; Region: PRK07877 479431000554 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 479431000555 ATP binding site [chemical binding]; other site 479431000556 substrate interface [chemical binding]; other site 479431000557 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 479431000558 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 479431000559 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 479431000560 NAD binding site [chemical binding]; other site 479431000561 dimer interface [polypeptide binding]; other site 479431000562 substrate binding site [chemical binding]; other site 479431000563 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479431000564 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 479431000565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479431000566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431000567 S-adenosylmethionine binding site [chemical binding]; other site 479431000568 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 479431000569 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 479431000570 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 479431000571 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 479431000572 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 479431000573 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 479431000574 putative DNA binding site [nucleotide binding]; other site 479431000575 catalytic residue [active] 479431000576 putative H2TH interface [polypeptide binding]; other site 479431000577 putative catalytic residues [active] 479431000578 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479431000579 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479431000580 Low molecular weight phosphatase family; Region: LMWPc; cl00105 479431000581 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 479431000582 active site 479431000583 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 479431000584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431000585 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479431000586 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 479431000587 active site residue [active] 479431000588 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 479431000589 CAAX protease self-immunity; Region: Abi; pfam02517 479431000590 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 479431000591 prephenate dehydratase; Provisional; Region: PRK11898 479431000592 Prephenate dehydratase; Region: PDT; pfam00800 479431000593 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 479431000594 putative L-Phe binding site [chemical binding]; other site 479431000595 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431000596 catalytic core [active] 479431000597 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479431000598 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431000599 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431000600 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 479431000601 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431000602 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 479431000603 putative substrate binding site [chemical binding]; other site 479431000604 putative ATP binding site [chemical binding]; other site 479431000605 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 479431000606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431000607 DNA-binding site [nucleotide binding]; DNA binding site 479431000608 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 479431000609 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479431000610 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431000611 active site 479431000612 metal binding site [ion binding]; metal-binding site 479431000613 hypothetical protein; Provisional; Region: PRK06126 479431000614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479431000615 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 479431000616 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 479431000617 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 479431000618 seryl-tRNA synthetase; Provisional; Region: PRK05431 479431000619 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 479431000620 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 479431000621 dimer interface [polypeptide binding]; other site 479431000622 active site 479431000623 motif 1; other site 479431000624 motif 2; other site 479431000625 motif 3; other site 479431000626 Uncharacterized conserved protein [Function unknown]; Region: COG5361 479431000627 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 479431000628 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 479431000629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431000630 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 479431000631 putative dimer interface [polypeptide binding]; other site 479431000632 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 479431000633 Domain of unknown function DUF21; Region: DUF21; pfam01595 479431000634 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479431000635 Transporter associated domain; Region: CorC_HlyC; smart01091 479431000636 allantoinase; Region: allantoinase; TIGR03178 479431000637 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431000638 active site 479431000639 allantoicase; Provisional; Region: PRK13257 479431000640 Allantoicase repeat; Region: Allantoicase; pfam03561 479431000641 Allantoicase repeat; Region: Allantoicase; pfam03561 479431000642 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 479431000643 active site 479431000644 homotetramer interface [polypeptide binding]; other site 479431000645 urate oxidase; Region: urate_oxi; TIGR03383 479431000646 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 479431000647 active site 479431000648 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 479431000649 hypothetical protein; Provisional; Region: PRK11171 479431000650 Cupin domain; Region: Cupin_2; pfam07883 479431000651 Cupin domain; Region: Cupin_2; pfam07883 479431000652 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 479431000653 glyoxylate carboligase; Provisional; Region: PRK11269 479431000654 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479431000655 PYR/PP interface [polypeptide binding]; other site 479431000656 dimer interface [polypeptide binding]; other site 479431000657 TPP binding site [chemical binding]; other site 479431000658 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479431000659 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 479431000660 TPP-binding site [chemical binding]; other site 479431000661 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479431000662 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479431000663 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 479431000664 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 479431000665 malate synthase A; Region: malate_syn_A; TIGR01344 479431000666 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 479431000667 active site 479431000668 xanthine permease; Region: pbuX; TIGR03173 479431000669 urate oxidase; Region: urate_oxi; TIGR03383 479431000670 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 479431000671 active site 479431000672 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 479431000673 active site 479431000674 homotetramer interface [polypeptide binding]; other site 479431000675 Hemerythrin-like domain; Region: Hr-like; cd12108 479431000676 Ion channel; Region: Ion_trans_2; pfam07885 479431000677 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 479431000678 active site 479431000679 catalytic triad [active] 479431000680 oxyanion hole [active] 479431000681 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431000682 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431000683 guanine deaminase; Provisional; Region: PRK09228 479431000684 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431000685 active site 479431000686 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 479431000687 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 479431000688 XdhC Rossmann domain; Region: XdhC_C; pfam13478 479431000689 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 479431000690 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 479431000691 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 479431000692 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 479431000693 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 479431000694 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 479431000695 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 479431000696 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 479431000697 active site 479431000698 putative substrate binding pocket [chemical binding]; other site 479431000699 xanthine permease; Region: pbuX; TIGR03173 479431000700 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 479431000701 putative OHCU decarboxylase; Provisional; Region: PRK13798 479431000702 HTH domain; Region: HTH_22; pfam13309 479431000703 Domain of unknown function DUF77; Region: DUF77; cl00307 479431000704 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479431000705 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 479431000706 Malic enzyme, N-terminal domain; Region: malic; pfam00390 479431000707 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 479431000708 putative NAD(P) binding site [chemical binding]; other site 479431000709 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431000710 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 479431000711 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431000712 xanthine permease; Region: pbuX; TIGR03173 479431000713 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 479431000714 active site 479431000715 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 479431000716 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 479431000717 alpha-gamma subunit interface [polypeptide binding]; other site 479431000718 beta-gamma subunit interface [polypeptide binding]; other site 479431000719 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 479431000720 alpha-beta subunit interface [polypeptide binding]; other site 479431000721 urease subunit alpha; Reviewed; Region: ureC; PRK13206 479431000722 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 479431000723 subunit interactions [polypeptide binding]; other site 479431000724 active site 479431000725 flap region; other site 479431000726 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 479431000727 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 479431000728 active site 2 [active] 479431000729 active site 1 [active] 479431000730 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 479431000731 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479431000732 UreD urease accessory protein; Region: UreD; cl00530 479431000733 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 479431000734 HNH endonuclease; Region: HNH; pfam01844 479431000735 active site 479431000736 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 479431000737 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 479431000738 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431000739 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431000740 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 479431000741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431000742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431000743 DNA binding residues [nucleotide binding] 479431000744 dimerization interface [polypeptide binding]; other site 479431000745 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479431000746 active site 479431000747 metal binding site [ion binding]; metal-binding site 479431000748 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479431000749 active site 479431000750 metal binding site [ion binding]; metal-binding site 479431000751 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 479431000752 PKC phosphorylation site [posttranslational modification]; other site 479431000753 hypothetical protein; Provisional; Region: PRK06541 479431000754 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479431000755 inhibitor-cofactor binding pocket; inhibition site 479431000756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431000757 catalytic residue [active] 479431000758 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431000759 dimerization interface [polypeptide binding]; other site 479431000760 putative DNA binding site [nucleotide binding]; other site 479431000761 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 479431000762 putative Zn2+ binding site [ion binding]; other site 479431000763 AsnC family; Region: AsnC_trans_reg; pfam01037 479431000764 agmatinase; Region: agmatinase; TIGR01230 479431000765 Agmatinase-like family; Region: Agmatinase-like; cd09990 479431000766 active site 479431000767 oligomer interface [polypeptide binding]; other site 479431000768 Mn binding site [ion binding]; other site 479431000769 Cytochrome P450; Region: p450; cl12078 479431000770 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479431000771 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 479431000772 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 479431000773 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 479431000774 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 479431000775 NAD(P) binding site [chemical binding]; other site 479431000776 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479431000777 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479431000778 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 479431000779 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 479431000780 EamA-like transporter family; Region: EamA; pfam00892 479431000781 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479431000782 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 479431000783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431000784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431000785 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 479431000786 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 479431000787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479431000788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431000789 Coenzyme A binding pocket [chemical binding]; other site 479431000790 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 479431000791 hypothetical protein; Provisional; Region: PRK10621 479431000792 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479431000793 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 479431000794 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431000795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431000796 homodimer interface [polypeptide binding]; other site 479431000797 catalytic residue [active] 479431000798 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 479431000799 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431000800 acyl-activating enzyme (AAE) consensus motif; other site 479431000801 AMP binding site [chemical binding]; other site 479431000802 active site 479431000803 CoA binding site [chemical binding]; other site 479431000804 CsbD-like; Region: CsbD; pfam05532 479431000805 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 479431000806 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 479431000807 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 479431000808 active site turn [active] 479431000809 phosphorylation site [posttranslational modification] 479431000810 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 479431000811 active site turn [active] 479431000812 phosphorylation site [posttranslational modification] 479431000813 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 479431000814 HPr interaction site; other site 479431000815 glycerol kinase (GK) interaction site [polypeptide binding]; other site 479431000816 active site 479431000817 phosphorylation site [posttranslational modification] 479431000818 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 479431000819 dimerization domain swap beta strand [polypeptide binding]; other site 479431000820 regulatory protein interface [polypeptide binding]; other site 479431000821 active site 479431000822 regulatory phosphorylation site [posttranslational modification]; other site 479431000823 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 479431000824 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 479431000825 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 479431000826 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 479431000827 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479431000828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 479431000829 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 479431000830 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479431000831 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431000832 active site 479431000833 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 479431000834 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431000835 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 479431000836 putative NAD(P) binding site [chemical binding]; other site 479431000837 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 479431000838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479431000839 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431000840 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 479431000841 RibD C-terminal domain; Region: RibD_C; cl17279 479431000842 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 479431000843 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479431000844 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479431000845 Zn2+ binding site [ion binding]; other site 479431000846 Mg2+ binding site [ion binding]; other site 479431000847 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431000848 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431000849 dimerization interface [polypeptide binding]; other site 479431000850 DNA binding residues [nucleotide binding] 479431000851 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 479431000852 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431000853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431000854 DNA binding residues [nucleotide binding] 479431000855 dimerization interface [polypeptide binding]; other site 479431000856 YceI-like domain; Region: YceI; pfam04264 479431000857 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 479431000858 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 479431000859 Moco binding site; other site 479431000860 metal coordination site [ion binding]; other site 479431000861 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 479431000862 Fasciclin domain; Region: Fasciclin; pfam02469 479431000863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479431000864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479431000865 active site 479431000866 catalytic tetrad [active] 479431000867 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 479431000868 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479431000869 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431000870 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431000871 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 479431000872 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 479431000873 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 479431000874 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 479431000875 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 479431000876 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 479431000877 ANTAR domain; Region: ANTAR; pfam03861 479431000878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431000879 Walker B; other site 479431000880 D-loop; other site 479431000881 H-loop/switch region; other site 479431000882 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 479431000883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479431000884 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 479431000885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431000886 NAD(P) binding site [chemical binding]; other site 479431000887 active site 479431000888 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 479431000889 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431000890 NAD binding site [chemical binding]; other site 479431000891 catalytic Zn binding site [ion binding]; other site 479431000892 structural Zn binding site [ion binding]; other site 479431000893 SAP domain; Region: SAP; pfam02037 479431000894 Fatty acid desaturase; Region: FA_desaturase; pfam00487 479431000895 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 479431000896 putative di-iron ligands [ion binding]; other site 479431000897 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431000898 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431000899 active site 479431000900 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 479431000901 active site 479431000902 catalytic residues [active] 479431000903 metal binding site [ion binding]; metal-binding site 479431000904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 479431000905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431000906 DsrC like protein; Region: DsrC; pfam04358 479431000907 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 479431000908 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 479431000909 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431000910 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431000911 Walker A/P-loop; other site 479431000912 ATP binding site [chemical binding]; other site 479431000913 Q-loop/lid; other site 479431000914 ABC transporter signature motif; other site 479431000915 Walker B; other site 479431000916 D-loop; other site 479431000917 H-loop/switch region; other site 479431000918 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 479431000919 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 479431000920 putative homotetramer interface [polypeptide binding]; other site 479431000921 putative homodimer interface [polypeptide binding]; other site 479431000922 putative allosteric switch controlling residues; other site 479431000923 putative metal binding site [ion binding]; other site 479431000924 putative homodimer-homodimer interface [polypeptide binding]; other site 479431000925 Domain of unknown function DUF302; Region: DUF302; pfam03625 479431000926 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479431000927 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 479431000928 catalytic residues [active] 479431000929 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479431000930 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 479431000931 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 479431000932 active site residue [active] 479431000933 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479431000934 OsmC-like protein; Region: OsmC; pfam02566 479431000935 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431000936 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431000937 active site 479431000938 ATP binding site [chemical binding]; other site 479431000939 substrate binding site [chemical binding]; other site 479431000940 activation loop (A-loop); other site 479431000941 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 479431000942 HTH domain; Region: HTH_11; pfam08279 479431000943 WYL domain; Region: WYL; pfam13280 479431000944 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 479431000945 active site 479431000946 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 479431000947 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479431000948 DNA binding residues [nucleotide binding] 479431000949 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479431000950 B12 binding domain; Region: B12-binding_2; pfam02607 479431000951 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 479431000952 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431000953 Domain of unknown function (DUF385); Region: DUF385; cl04387 479431000954 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 479431000955 hypothetical protein; Validated; Region: PRK07581 479431000956 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479431000957 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431000958 active site 479431000959 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431000960 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431000961 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479431000962 Peptidase family M23; Region: Peptidase_M23; pfam01551 479431000963 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 479431000964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431000965 Predicted permease; Region: DUF318; cl17795 479431000966 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 479431000967 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 479431000968 gamma subunit interface [polypeptide binding]; other site 479431000969 epsilon subunit interface [polypeptide binding]; other site 479431000970 LBP interface [polypeptide binding]; other site 479431000971 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 479431000972 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 479431000973 hypothetical protein; Provisional; Region: PRK07588 479431000974 hypothetical protein; Provisional; Region: PRK07236 479431000975 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479431000976 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431000977 MarR family; Region: MarR; pfam01047 479431000978 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 479431000979 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 479431000980 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 479431000981 ligand binding site [chemical binding]; other site 479431000982 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479431000983 TM-ABC transporter signature motif; other site 479431000984 Predicted membrane protein [Function unknown]; Region: COG4325 479431000985 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 479431000986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431000987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431000988 active site 479431000989 phosphorylation site [posttranslational modification] 479431000990 intermolecular recognition site; other site 479431000991 dimerization interface [polypeptide binding]; other site 479431000992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431000993 DNA binding site [nucleotide binding] 479431000994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431000995 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479431000996 dimerization interface [polypeptide binding]; other site 479431000997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431000998 dimer interface [polypeptide binding]; other site 479431000999 phosphorylation site [posttranslational modification] 479431001000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431001001 ATP binding site [chemical binding]; other site 479431001002 G-X-G motif; other site 479431001003 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 479431001004 Predicted membrane protein [Function unknown]; Region: COG2323 479431001005 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 479431001006 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 479431001007 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431001008 Ligand Binding Site [chemical binding]; other site 479431001009 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 479431001010 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 479431001011 TrkA-C domain; Region: TrkA_C; pfam02080 479431001012 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 479431001013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431001014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431001015 active site 479431001016 phosphorylation site [posttranslational modification] 479431001017 intermolecular recognition site; other site 479431001018 dimerization interface [polypeptide binding]; other site 479431001019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431001020 DNA binding residues [nucleotide binding] 479431001021 dimerization interface [polypeptide binding]; other site 479431001022 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479431001023 Helix-turn-helix domain; Region: HTH_38; pfam13936 479431001024 CAAX protease self-immunity; Region: Abi; pfam02517 479431001025 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431001026 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 479431001027 catalytic site [active] 479431001028 AAA ATPase domain; Region: AAA_16; pfam13191 479431001029 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431001030 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431001031 dimerization interface [polypeptide binding]; other site 479431001032 DNA binding residues [nucleotide binding] 479431001033 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 479431001034 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 479431001035 conserved cys residue [active] 479431001036 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431001037 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 479431001038 putative NAD(P) binding site [chemical binding]; other site 479431001039 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431001040 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 479431001041 putative NAD(P) binding site [chemical binding]; other site 479431001042 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479431001043 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 479431001044 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 479431001045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431001046 DNA binding residues [nucleotide binding] 479431001047 dimerization interface [polypeptide binding]; other site 479431001048 transposase/IS protein; Provisional; Region: PRK09183 479431001049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431001050 Walker A motif; other site 479431001051 ATP binding site [chemical binding]; other site 479431001052 Walker B motif; other site 479431001053 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431001054 MULE transposase domain; Region: MULE; pfam10551 479431001055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431001057 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 479431001058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431001059 non-specific DNA binding site [nucleotide binding]; other site 479431001060 salt bridge; other site 479431001061 sequence-specific DNA binding site [nucleotide binding]; other site 479431001062 Cupin domain; Region: Cupin_2; pfam07883 479431001063 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 479431001064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 479431001065 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431001066 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479431001067 active site 479431001068 DNA binding site [nucleotide binding] 479431001069 Int/Topo IB signature motif; other site 479431001070 SIR2-like domain; Region: SIR2_2; pfam13289 479431001071 FRG domain; Region: FRG; pfam08867 479431001072 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431001073 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431001074 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 479431001075 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 479431001076 AAA-like domain; Region: AAA_10; pfam12846 479431001077 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 479431001078 putative trimer interface [polypeptide binding]; other site 479431001079 putative CoA binding site [chemical binding]; other site 479431001080 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 479431001081 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 479431001082 Protein of unknown function (DUF968); Region: DUF968; pfam06147 479431001083 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431001084 active site 479431001085 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 479431001086 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 479431001087 dimer interface [polypeptide binding]; other site 479431001088 ssDNA binding site [nucleotide binding]; other site 479431001089 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479431001090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431001091 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431001092 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 479431001093 putative active site [active] 479431001094 catalytic site [active] 479431001095 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479431001096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431001097 ATP binding site [chemical binding]; other site 479431001098 putative Mg++ binding site [ion binding]; other site 479431001099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431001100 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 479431001101 nucleotide binding region [chemical binding]; other site 479431001102 ATP-binding site [chemical binding]; other site 479431001103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431001104 ATP-binding site [chemical binding]; other site 479431001105 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 479431001106 Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132 479431001107 PLD-like domain; Region: PLDc_2; pfam13091 479431001108 putative active site [active] 479431001109 putative catalytic site [active] 479431001110 Uncharacterized conserved protein [Function unknown]; Region: COG1479 479431001111 Protein of unknown function DUF262; Region: DUF262; pfam03235 479431001112 Protein of unknown function DUF262; Region: DUF262; pfam03235 479431001113 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 479431001114 Protein of unknown function (DUF1152); Region: DUF1152; pfam06626 479431001115 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 479431001116 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 479431001117 nudix motif; other site 479431001118 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479431001119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431001120 DNA-binding site [nucleotide binding]; DNA binding site 479431001121 UTRA domain; Region: UTRA; cl17743 479431001122 Helix-turn-helix domain; Region: HTH_17; cl17695 479431001123 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 479431001124 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 479431001125 Int/Topo IB signature motif; other site 479431001126 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431001127 active site 479431001128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431001129 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431001130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431001131 active site 479431001132 phosphorylation site [posttranslational modification] 479431001133 intermolecular recognition site; other site 479431001134 dimerization interface [polypeptide binding]; other site 479431001135 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431001136 DNA binding residues [nucleotide binding] 479431001137 dimerization interface [polypeptide binding]; other site 479431001138 Predicted permease [General function prediction only]; Region: COG2985 479431001139 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 479431001140 TrkA-C domain; Region: TrkA_C; pfam02080 479431001141 TrkA-C domain; Region: TrkA_C; pfam02080 479431001142 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 479431001143 NAD synthetase; Reviewed; Region: nadE; PRK02628 479431001144 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 479431001145 multimer interface [polypeptide binding]; other site 479431001146 active site 479431001147 catalytic triad [active] 479431001148 protein interface 1 [polypeptide binding]; other site 479431001149 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 479431001150 homodimer interface [polypeptide binding]; other site 479431001151 NAD binding pocket [chemical binding]; other site 479431001152 ATP binding pocket [chemical binding]; other site 479431001153 Mg binding site [ion binding]; other site 479431001154 active-site loop [active] 479431001155 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479431001156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001157 putative substrate translocation pore; other site 479431001158 MarR family; Region: MarR_2; cl17246 479431001159 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 479431001160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431001161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431001162 ATP binding site [chemical binding]; other site 479431001163 Mg2+ binding site [ion binding]; other site 479431001164 G-X-G motif; other site 479431001165 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431001166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431001167 active site 479431001168 phosphorylation site [posttranslational modification] 479431001169 intermolecular recognition site; other site 479431001170 dimerization interface [polypeptide binding]; other site 479431001171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431001172 DNA binding residues [nucleotide binding] 479431001173 dimerization interface [polypeptide binding]; other site 479431001174 TIGR03086 family protein; Region: TIGR03086 479431001175 DNA polymerase IV; Validated; Region: PRK03352 479431001176 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 479431001177 active site 479431001178 DNA binding site [nucleotide binding] 479431001179 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 479431001180 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 479431001181 transmembrane helices; other site 479431001182 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 479431001183 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 479431001184 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 479431001185 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 479431001186 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 479431001187 putative active site [active] 479431001188 metal binding site [ion binding]; metal-binding site 479431001189 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 479431001190 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479431001191 SnoaL-like domain; Region: SnoaL_2; pfam12680 479431001192 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 479431001193 heme-binding site [chemical binding]; other site 479431001194 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 479431001195 FMN reductase; Validated; Region: fre; PRK08051 479431001196 FAD binding pocket [chemical binding]; other site 479431001197 FAD binding motif [chemical binding]; other site 479431001198 phosphate binding motif [ion binding]; other site 479431001199 beta-alpha-beta structure motif; other site 479431001200 NAD binding pocket [chemical binding]; other site 479431001201 MMPL family; Region: MMPL; pfam03176 479431001202 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479431001203 DNA binding site [nucleotide binding] 479431001204 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479431001205 AAA ATPase domain; Region: AAA_16; pfam13191 479431001206 AAA domain; Region: AAA_22; pfam13401 479431001207 Hemerythrin-like domain; Region: Hr-like; cd12108 479431001208 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 479431001209 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 479431001210 trimer interface [polypeptide binding]; other site 479431001211 putative metal binding site [ion binding]; other site 479431001212 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431001213 catalytic core [active] 479431001214 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 479431001215 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 479431001216 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 479431001217 Domain of unknown function DUF20; Region: UPF0118; pfam01594 479431001218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 479431001219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 479431001220 guanine deaminase; Provisional; Region: PRK09228 479431001221 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431001222 active site 479431001223 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 479431001224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431001225 ATP binding site [chemical binding]; other site 479431001226 putative Mg++ binding site [ion binding]; other site 479431001227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431001228 nucleotide binding region [chemical binding]; other site 479431001229 ATP-binding site [chemical binding]; other site 479431001230 Helicase associated domain (HA2); Region: HA2; pfam04408 479431001231 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 479431001232 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 479431001233 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479431001234 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 479431001235 Putative glucoamylase; Region: Glycoamylase; pfam10091 479431001236 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 479431001237 beta-galactosidase; Region: BGL; TIGR03356 479431001238 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479431001239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431001240 dimer interface [polypeptide binding]; other site 479431001241 conserved gate region; other site 479431001242 putative PBP binding loops; other site 479431001243 ABC-ATPase subunit interface; other site 479431001244 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479431001245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431001246 dimer interface [polypeptide binding]; other site 479431001247 conserved gate region; other site 479431001248 putative PBP binding loops; other site 479431001249 ABC-ATPase subunit interface; other site 479431001250 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479431001251 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479431001252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431001253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431001254 DNA binding site [nucleotide binding] 479431001255 domain linker motif; other site 479431001256 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431001257 dimerization interface [polypeptide binding]; other site 479431001258 ligand binding site [chemical binding]; other site 479431001259 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 479431001260 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 479431001261 transaminase; Validated; Region: PRK07324 479431001262 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431001263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431001264 homodimer interface [polypeptide binding]; other site 479431001265 catalytic residue [active] 479431001266 YheO-like PAS domain; Region: PAS_6; pfam08348 479431001267 HTH domain; Region: HTH_22; pfam13309 479431001268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431001269 Histidine kinase; Region: HisKA_3; pfam07730 479431001270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431001271 ATP binding site [chemical binding]; other site 479431001272 Mg2+ binding site [ion binding]; other site 479431001273 G-X-G motif; other site 479431001274 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431001275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431001276 active site 479431001277 phosphorylation site [posttranslational modification] 479431001278 intermolecular recognition site; other site 479431001279 dimerization interface [polypeptide binding]; other site 479431001280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431001281 DNA binding residues [nucleotide binding] 479431001282 dimerization interface [polypeptide binding]; other site 479431001283 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 479431001284 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479431001285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431001286 Walker A/P-loop; other site 479431001287 ATP binding site [chemical binding]; other site 479431001288 Q-loop/lid; other site 479431001289 ABC transporter signature motif; other site 479431001290 Walker B; other site 479431001291 D-loop; other site 479431001292 H-loop/switch region; other site 479431001293 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479431001294 AAA domain; Region: AAA_33; pfam13671 479431001295 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479431001296 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431001297 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 479431001298 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 479431001299 AsnC family; Region: AsnC_trans_reg; pfam01037 479431001300 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 479431001301 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 479431001302 dimer interface [polypeptide binding]; other site 479431001303 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 479431001304 active site 479431001305 Fe binding site [ion binding]; other site 479431001306 fumarylacetoacetase; Region: PLN02856 479431001307 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 479431001308 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 479431001309 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 479431001310 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479431001311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431001312 S-adenosylmethionine binding site [chemical binding]; other site 479431001313 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 479431001314 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 479431001315 nucleoside/Zn binding site; other site 479431001316 dimer interface [polypeptide binding]; other site 479431001317 catalytic motif [active] 479431001318 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 479431001319 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 479431001320 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 479431001321 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 479431001322 NAD binding site [chemical binding]; other site 479431001323 substrate binding site [chemical binding]; other site 479431001324 catalytic Zn binding site [ion binding]; other site 479431001325 structural Zn binding site [ion binding]; other site 479431001326 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479431001327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431001329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431001330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431001331 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431001332 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479431001333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431001334 NAD(P) binding site [chemical binding]; other site 479431001335 active site 479431001336 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431001337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431001338 active site 479431001339 phosphorylation site [posttranslational modification] 479431001340 intermolecular recognition site; other site 479431001341 dimerization interface [polypeptide binding]; other site 479431001342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431001343 DNA binding residues [nucleotide binding] 479431001344 dimerization interface [polypeptide binding]; other site 479431001345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431001346 Histidine kinase; Region: HisKA_3; pfam07730 479431001347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431001348 ATP binding site [chemical binding]; other site 479431001349 Mg2+ binding site [ion binding]; other site 479431001350 G-X-G motif; other site 479431001351 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 479431001352 Predicted transcriptional regulators [Transcription]; Region: COG1725 479431001353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431001354 DNA-binding site [nucleotide binding]; DNA binding site 479431001355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431001356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431001357 active site 479431001358 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 479431001359 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 479431001360 metal ion-dependent adhesion site (MIDAS); other site 479431001361 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 479431001362 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 479431001363 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 479431001364 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 479431001365 nucleotide binding site [chemical binding]; other site 479431001366 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 479431001367 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 479431001368 active site 479431001369 glutaminase; Provisional; Region: PRK00971 479431001370 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 479431001371 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 479431001372 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 479431001373 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479431001374 ligand binding site [chemical binding]; other site 479431001375 flexible hinge region; other site 479431001376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001377 cyanate transporter; Region: CynX; TIGR00896 479431001378 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431001379 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479431001380 putative hydrophobic ligand binding site [chemical binding]; other site 479431001381 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479431001382 CGNR zinc finger; Region: zf-CGNR; pfam11706 479431001383 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 479431001384 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 479431001385 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 479431001386 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 479431001387 tetrameric interface [polypeptide binding]; other site 479431001388 NAD binding site [chemical binding]; other site 479431001389 catalytic residues [active] 479431001390 substrate binding site [chemical binding]; other site 479431001391 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 479431001392 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479431001393 hypothetical protein; Provisional; Region: PRK06541 479431001394 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479431001395 inhibitor-cofactor binding pocket; inhibition site 479431001396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431001397 catalytic residue [active] 479431001398 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 479431001399 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 479431001400 hexamer interface [polypeptide binding]; other site 479431001401 ligand binding site [chemical binding]; other site 479431001402 putative active site [active] 479431001403 NAD(P) binding site [chemical binding]; other site 479431001404 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 479431001405 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 479431001406 active site 479431001407 HIGH motif; other site 479431001408 nucleotide binding site [chemical binding]; other site 479431001409 active site 479431001410 KMSKS motif; other site 479431001411 aminoglycoside resistance protein; Provisional; Region: PRK13746 479431001412 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 479431001413 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 479431001414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001415 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 479431001416 beta-galactosidase; Region: BGL; TIGR03356 479431001417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431001418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431001419 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479431001420 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479431001421 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 479431001422 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431001423 Walker A/P-loop; other site 479431001424 ATP binding site [chemical binding]; other site 479431001425 Q-loop/lid; other site 479431001426 ABC transporter signature motif; other site 479431001427 Walker B; other site 479431001428 D-loop; other site 479431001429 H-loop/switch region; other site 479431001430 phosphate acetyltransferase; Reviewed; Region: PRK05632 479431001431 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479431001432 DRTGG domain; Region: DRTGG; pfam07085 479431001433 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 479431001434 propionate/acetate kinase; Provisional; Region: PRK12379 479431001435 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 479431001436 Predicted permeases [General function prediction only]; Region: COG0679 479431001437 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 479431001438 Universal stress protein family; Region: Usp; pfam00582 479431001439 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 479431001440 nucleotide binding site [chemical binding]; other site 479431001441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431001442 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479431001443 NAD(P) binding site [chemical binding]; other site 479431001444 active site 479431001445 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 479431001446 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 479431001447 DNA-binding site [nucleotide binding]; DNA binding site 479431001448 RNA-binding motif; other site 479431001449 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 479431001450 PaaX-like protein; Region: PaaX; pfam07848 479431001451 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 479431001452 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479431001453 kynureninase; Region: kynureninase; TIGR01814 479431001454 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 479431001455 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 479431001456 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 479431001457 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 479431001458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431001459 catalytic residue [active] 479431001460 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 479431001461 Part of AAA domain; Region: AAA_19; pfam13245 479431001462 Family description; Region: UvrD_C_2; pfam13538 479431001463 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 479431001464 minor groove reading motif; other site 479431001465 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479431001466 helix-hairpin-helix signature motif; other site 479431001467 active site 479431001468 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479431001469 Nitronate monooxygenase; Region: NMO; pfam03060 479431001470 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 479431001471 FMN binding site [chemical binding]; other site 479431001472 substrate binding site [chemical binding]; other site 479431001473 putative catalytic residue [active] 479431001474 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 479431001475 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 479431001476 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 479431001477 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431001478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431001479 DNA binding site [nucleotide binding] 479431001480 domain linker motif; other site 479431001481 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479431001482 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479431001483 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 479431001484 inhibitor site; inhibition site 479431001485 active site 479431001486 dimer interface [polypeptide binding]; other site 479431001487 catalytic residue [active] 479431001488 benzoate transport; Region: 2A0115; TIGR00895 479431001489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001490 putative substrate translocation pore; other site 479431001491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001493 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431001494 putative substrate translocation pore; other site 479431001495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001496 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 479431001497 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 479431001498 Moco binding site; other site 479431001499 metal coordination site [ion binding]; other site 479431001500 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 479431001501 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 479431001502 FAD binding pocket [chemical binding]; other site 479431001503 conserved FAD binding motif [chemical binding]; other site 479431001504 phosphate binding motif [ion binding]; other site 479431001505 beta-alpha-beta structure motif; other site 479431001506 NAD binding pocket [chemical binding]; other site 479431001507 Histidine kinase; Region: HisKA_3; pfam07730 479431001508 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479431001509 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431001510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431001511 active site 479431001512 phosphorylation site [posttranslational modification] 479431001513 intermolecular recognition site; other site 479431001514 dimerization interface [polypeptide binding]; other site 479431001515 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431001516 DNA binding residues [nucleotide binding] 479431001517 dimerization interface [polypeptide binding]; other site 479431001518 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 479431001519 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 479431001520 Domain of unknown function (DUF222); Region: DUF222; pfam02720 479431001521 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479431001522 active site 479431001523 Uncharacterized conserved protein [Function unknown]; Region: COG3268 479431001524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431001525 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 479431001526 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 479431001527 active site 479431001528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431001529 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431001530 Domain of unknown function (DUF389); Region: DUF389; cl00781 479431001531 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479431001532 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431001533 active site 479431001534 metal binding site [ion binding]; metal-binding site 479431001535 phosphoenolpyruvate synthase; Validated; Region: PRK06241 479431001536 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 479431001537 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 479431001538 Protein of unknown function (DUF429); Region: DUF429; cl12046 479431001539 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 479431001540 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431001541 active site 479431001542 RibD C-terminal domain; Region: RibD_C; cl17279 479431001543 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 479431001544 putative NAD(P) binding site [chemical binding]; other site 479431001545 active site 479431001546 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 479431001547 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 479431001548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431001549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431001550 putative transposase OrfB; Reviewed; Region: PHA02517 479431001551 HTH-like domain; Region: HTH_21; pfam13276 479431001552 Integrase core domain; Region: rve; pfam00665 479431001553 Integrase core domain; Region: rve_3; cl15866 479431001554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431001555 Transposase; Region: HTH_Tnp_1; cl17663 479431001556 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 479431001557 nudix motif; other site 479431001558 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479431001559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431001560 DNA-binding site [nucleotide binding]; DNA binding site 479431001561 UTRA domain; Region: UTRA; pfam07702 479431001562 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 479431001563 AAA-like domain; Region: AAA_10; pfam12846 479431001564 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 479431001565 Helix-turn-helix domain; Region: HTH_17; cl17695 479431001566 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431001567 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479431001568 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431001569 active site 479431001570 DNA binding site [nucleotide binding] 479431001571 Int/Topo IB signature motif; other site 479431001572 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 479431001573 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 479431001574 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479431001575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431001576 DNA-binding site [nucleotide binding]; DNA binding site 479431001577 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479431001578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431001579 catalytic residue [active] 479431001580 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 479431001581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431001582 Walker A motif; other site 479431001583 ATP binding site [chemical binding]; other site 479431001584 Walker B motif; other site 479431001585 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 479431001586 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 479431001587 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431001588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431001589 active site 479431001590 phosphorylation site [posttranslational modification] 479431001591 intermolecular recognition site; other site 479431001592 dimerization interface [polypeptide binding]; other site 479431001593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431001594 DNA binding residues [nucleotide binding] 479431001595 dimerization interface [polypeptide binding]; other site 479431001596 Histidine kinase; Region: HisKA_3; pfam07730 479431001597 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479431001598 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479431001599 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 479431001600 putative metal binding site [ion binding]; other site 479431001601 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431001602 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431001603 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479431001604 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 479431001605 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 479431001606 dimer interface [polypeptide binding]; other site 479431001607 active site 479431001608 glycine-pyridoxal phosphate binding site [chemical binding]; other site 479431001609 folate binding site [chemical binding]; other site 479431001610 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 479431001611 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479431001612 peptide binding site [polypeptide binding]; other site 479431001613 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479431001614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431001615 dimer interface [polypeptide binding]; other site 479431001616 conserved gate region; other site 479431001617 putative PBP binding loops; other site 479431001618 ABC-ATPase subunit interface; other site 479431001619 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479431001620 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 479431001621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431001622 ABC-ATPase subunit interface; other site 479431001623 putative PBP binding loops; other site 479431001624 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479431001625 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479431001626 Walker A/P-loop; other site 479431001627 ATP binding site [chemical binding]; other site 479431001628 Q-loop/lid; other site 479431001629 ABC transporter signature motif; other site 479431001630 Walker B; other site 479431001631 D-loop; other site 479431001632 H-loop/switch region; other site 479431001633 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479431001634 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 479431001635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479431001636 Walker A/P-loop; other site 479431001637 ATP binding site [chemical binding]; other site 479431001638 Q-loop/lid; other site 479431001639 ABC transporter signature motif; other site 479431001640 Walker B; other site 479431001641 D-loop; other site 479431001642 H-loop/switch region; other site 479431001643 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 479431001644 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431001645 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479431001646 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431001647 Isochorismatase family; Region: Isochorismatase; pfam00857 479431001648 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 479431001649 catalytic triad [active] 479431001650 conserved cis-peptide bond; other site 479431001651 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 479431001652 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479431001653 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479431001654 Uncharacterized conserved protein [Function unknown]; Region: COG1359 479431001655 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 479431001656 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 479431001657 substrate binding pocket [chemical binding]; other site 479431001658 catalytic triad [active] 479431001659 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 479431001660 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 479431001661 active site 479431001662 metal binding site [ion binding]; metal-binding site 479431001663 hypothetical protein; Validated; Region: PRK00153 479431001664 recombination protein RecR; Reviewed; Region: recR; PRK00076 479431001665 RecR protein; Region: RecR; pfam02132 479431001666 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 479431001667 putative active site [active] 479431001668 putative metal-binding site [ion binding]; other site 479431001669 tetramer interface [polypeptide binding]; other site 479431001670 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 479431001671 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479431001672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479431001673 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431001674 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479431001675 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 479431001676 classical (c) SDRs; Region: SDR_c; cd05233 479431001677 NAD(P) binding site [chemical binding]; other site 479431001678 active site 479431001679 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 479431001680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431001681 active site 479431001682 phosphorylation site [posttranslational modification] 479431001683 intermolecular recognition site; other site 479431001684 ANTAR domain; Region: ANTAR; pfam03861 479431001685 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479431001686 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479431001687 nucleotide binding site [chemical binding]; other site 479431001688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431001689 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431001690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431001691 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431001692 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 479431001693 active site 479431001694 catalytic triad [active] 479431001695 oxyanion hole [active] 479431001696 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 479431001697 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 479431001698 nudix motif; other site 479431001699 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431001700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431001702 putative substrate translocation pore; other site 479431001703 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 479431001704 2-isopropylmalate synthase; Validated; Region: PRK03739 479431001705 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 479431001706 active site 479431001707 catalytic residues [active] 479431001708 metal binding site [ion binding]; metal-binding site 479431001709 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 479431001710 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 479431001711 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479431001712 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 479431001713 aspartate kinase; Reviewed; Region: PRK06635 479431001714 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 479431001715 putative nucleotide binding site [chemical binding]; other site 479431001716 putative catalytic residues [active] 479431001717 putative Mg ion binding site [ion binding]; other site 479431001718 putative aspartate binding site [chemical binding]; other site 479431001719 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 479431001720 putative allosteric regulatory site; other site 479431001721 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 479431001722 putative allosteric regulatory residue; other site 479431001723 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 479431001724 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 479431001725 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 479431001726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 479431001727 hypothetical protein; Provisional; Region: PRK07236 479431001728 classical (c) SDRs; Region: SDR_c; cd05233 479431001729 NAD(P) binding site [chemical binding]; other site 479431001730 active site 479431001731 translocation protein TolB; Provisional; Region: tolB; PRK04922 479431001732 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479431001733 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 479431001734 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 479431001735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431001736 acyl-activating enzyme (AAE) consensus motif; other site 479431001737 AMP binding site [chemical binding]; other site 479431001738 active site 479431001739 CoA binding site [chemical binding]; other site 479431001740 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 479431001741 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479431001742 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 479431001743 PKC phosphorylation site [posttranslational modification]; other site 479431001744 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 479431001745 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479431001746 putative active site [active] 479431001747 putative metal binding site [ion binding]; other site 479431001748 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 479431001749 Transglycosylase; Region: Transgly; pfam00912 479431001750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 479431001751 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431001752 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 479431001753 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 479431001754 P loop; other site 479431001755 Nucleotide binding site [chemical binding]; other site 479431001756 DTAP/Switch II; other site 479431001757 Switch I; other site 479431001758 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479431001759 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 479431001760 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 479431001761 DTAP/Switch II; other site 479431001762 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 479431001763 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 479431001764 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 479431001765 homotrimer interaction site [polypeptide binding]; other site 479431001766 putative active site [active] 479431001767 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479431001768 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479431001769 nudix motif; other site 479431001770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479431001771 Methyltransferase domain; Region: Methyltransf_11; pfam08241 479431001772 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 479431001773 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479431001774 ligand binding site [chemical binding]; other site 479431001775 flexible hinge region; other site 479431001776 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 479431001777 putative switch regulator; other site 479431001778 non-specific DNA interactions [nucleotide binding]; other site 479431001779 DNA binding site [nucleotide binding] 479431001780 sequence specific DNA binding site [nucleotide binding]; other site 479431001781 putative cAMP binding site [chemical binding]; other site 479431001782 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 479431001783 endonuclease III; Region: ENDO3c; smart00478 479431001784 minor groove reading motif; other site 479431001785 helix-hairpin-helix signature motif; other site 479431001786 substrate binding pocket [chemical binding]; other site 479431001787 active site 479431001788 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 479431001789 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 479431001790 putative active site [active] 479431001791 putative CoA binding site [chemical binding]; other site 479431001792 nudix motif; other site 479431001793 metal binding site [ion binding]; metal-binding site 479431001794 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 479431001795 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 479431001796 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431001797 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431001798 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 479431001799 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 479431001800 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 479431001801 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 479431001802 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 479431001803 acetyl-CoA synthetase; Provisional; Region: PRK00174 479431001804 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 479431001805 active site 479431001806 CoA binding site [chemical binding]; other site 479431001807 acyl-activating enzyme (AAE) consensus motif; other site 479431001808 AMP binding site [chemical binding]; other site 479431001809 acetate binding site [chemical binding]; other site 479431001810 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 479431001811 Type II/IV secretion system protein; Region: T2SE; pfam00437 479431001812 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 479431001813 ATP binding site [chemical binding]; other site 479431001814 Walker A motif; other site 479431001815 hexamer interface [polypeptide binding]; other site 479431001816 Walker B motif; other site 479431001817 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 479431001818 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 479431001819 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431001820 ATP binding site [chemical binding]; other site 479431001821 putative Mg++ binding site [ion binding]; other site 479431001822 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 479431001823 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 479431001824 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 479431001825 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 479431001826 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 479431001827 active site 479431001828 interdomain interaction site; other site 479431001829 putative metal-binding site [ion binding]; other site 479431001830 nucleotide binding site [chemical binding]; other site 479431001831 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 479431001832 domain I; other site 479431001833 phosphate binding site [ion binding]; other site 479431001834 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 479431001835 domain II; other site 479431001836 domain III; other site 479431001837 nucleotide binding site [chemical binding]; other site 479431001838 DNA binding groove [nucleotide binding] 479431001839 catalytic site [active] 479431001840 domain IV; other site 479431001841 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 479431001842 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 479431001843 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 479431001844 H+ Antiporter protein; Region: 2A0121; TIGR00900 479431001845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001847 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 479431001848 active site 479431001849 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 479431001850 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431001851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431001852 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479431001853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431001854 S-adenosylmethionine binding site [chemical binding]; other site 479431001855 DNA polymerase III subunit delta'; Validated; Region: PRK07940 479431001856 DNA polymerase III subunit delta'; Validated; Region: PRK08485 479431001857 PSP1 C-terminal conserved region; Region: PSP1; cl00770 479431001858 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 479431001859 iron-sulfur cluster [ion binding]; other site 479431001860 [2Fe-2S] cluster binding site [ion binding]; other site 479431001861 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 479431001862 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 479431001863 PA/protease or protease-like domain interface [polypeptide binding]; other site 479431001864 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 479431001865 Peptidase family M28; Region: Peptidase_M28; pfam04389 479431001866 active site 479431001867 metal binding site [ion binding]; metal-binding site 479431001868 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 479431001869 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 479431001870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 479431001871 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479431001872 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431001873 putative DNA binding site [nucleotide binding]; other site 479431001874 putative Zn2+ binding site [ion binding]; other site 479431001875 MarR family; Region: MarR_2; cl17246 479431001876 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 479431001877 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 479431001878 putative active site [active] 479431001879 metal binding site [ion binding]; metal-binding site 479431001880 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 479431001881 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 479431001882 catalytic motif [active] 479431001883 Zn binding site [ion binding]; other site 479431001884 RibD C-terminal domain; Region: RibD_C; cl17279 479431001885 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 479431001886 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 479431001887 PA/protease or protease-like domain interface [polypeptide binding]; other site 479431001888 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 479431001889 Peptidase family M28; Region: Peptidase_M28; pfam04389 479431001890 active site 479431001891 metal binding site [ion binding]; metal-binding site 479431001892 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 479431001893 active site residue [active] 479431001894 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 479431001895 Zn binding site [ion binding]; other site 479431001896 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431001897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431001898 Walker A/P-loop; other site 479431001899 ATP binding site [chemical binding]; other site 479431001900 Q-loop/lid; other site 479431001901 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 479431001902 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 479431001903 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431001904 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431001905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431001906 Walker A/P-loop; other site 479431001907 ATP binding site [chemical binding]; other site 479431001908 Q-loop/lid; other site 479431001909 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 479431001910 Predicted membrane protein [Function unknown]; Region: COG1511 479431001911 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 479431001912 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431001913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431001914 putative DNA binding site [nucleotide binding]; other site 479431001915 putative Zn2+ binding site [ion binding]; other site 479431001916 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479431001917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001918 putative substrate translocation pore; other site 479431001919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431001920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431001921 S-adenosylmethionine binding site [chemical binding]; other site 479431001922 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431001923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431001924 active site 479431001925 phosphorylation site [posttranslational modification] 479431001926 intermolecular recognition site; other site 479431001927 dimerization interface [polypeptide binding]; other site 479431001928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431001929 DNA binding residues [nucleotide binding] 479431001930 dimerization interface [polypeptide binding]; other site 479431001931 GAF domain; Region: GAF_3; pfam13492 479431001932 Histidine kinase; Region: HisKA_3; pfam07730 479431001933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431001934 ATP binding site [chemical binding]; other site 479431001935 Mg2+ binding site [ion binding]; other site 479431001936 G-X-G motif; other site 479431001937 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 479431001938 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 479431001939 active site 479431001940 NAD binding site [chemical binding]; other site 479431001941 metal binding site [ion binding]; metal-binding site 479431001942 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 479431001943 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479431001944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479431001945 active site 479431001946 classical (c) SDRs; Region: SDR_c; cd05233 479431001947 NAD(P) binding site [chemical binding]; other site 479431001948 active site 479431001949 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479431001950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431001951 mycofactocin precursor; Region: mycofactocin; TIGR03969 479431001952 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 479431001953 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 479431001954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431001955 FeS/SAM binding site; other site 479431001956 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 479431001957 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 479431001958 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 479431001959 phosphate binding site [ion binding]; other site 479431001960 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 479431001961 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 479431001962 active site 479431001963 NAD binding site [chemical binding]; other site 479431001964 metal binding site [ion binding]; metal-binding site 479431001965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431001966 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479431001967 Walker A motif; other site 479431001968 ATP binding site [chemical binding]; other site 479431001969 Walker B motif; other site 479431001970 arginine finger; other site 479431001971 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 479431001972 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 479431001973 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 479431001974 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 479431001975 Walker A/P-loop; other site 479431001976 ATP binding site [chemical binding]; other site 479431001977 Q-loop/lid; other site 479431001978 ABC transporter signature motif; other site 479431001979 Walker B; other site 479431001980 D-loop; other site 479431001981 H-loop/switch region; other site 479431001982 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479431001983 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479431001984 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431001985 catalytic residue [active] 479431001986 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 479431001987 Hemerythrin-like domain; Region: Hr-like; cd12108 479431001988 Fe binding site [ion binding]; other site 479431001989 Homeodomain-like domain; Region: HTH_23; cl17451 479431001990 Winged helix-turn helix; Region: HTH_29; pfam13551 479431001991 Integrase core domain; Region: rve; pfam00665 479431001992 Integrase core domain; Region: rve_3; pfam13683 479431001993 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 479431001994 amphipathic channel; other site 479431001995 Asn-Pro-Ala signature motifs; other site 479431001996 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 479431001997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431001998 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 479431001999 substrate binding pocket [chemical binding]; other site 479431002000 dimerization interface [polypeptide binding]; other site 479431002001 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479431002002 homotrimer interaction site [polypeptide binding]; other site 479431002003 putative active site [active] 479431002004 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479431002005 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 479431002006 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479431002007 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479431002008 putative acyl-acceptor binding pocket; other site 479431002009 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 479431002010 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 479431002011 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479431002012 DNA binding site [nucleotide binding] 479431002013 active site 479431002014 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 479431002015 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431002016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431002017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431002018 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479431002019 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479431002020 Walker A/P-loop; other site 479431002021 ATP binding site [chemical binding]; other site 479431002022 Q-loop/lid; other site 479431002023 ABC transporter signature motif; other site 479431002024 Walker B; other site 479431002025 D-loop; other site 479431002026 H-loop/switch region; other site 479431002027 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479431002028 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 479431002029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431002030 putative substrate translocation pore; other site 479431002031 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 479431002032 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479431002033 substrate binding site [chemical binding]; other site 479431002034 oxyanion hole (OAH) forming residues; other site 479431002035 trimer interface [polypeptide binding]; other site 479431002036 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 479431002037 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479431002038 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 479431002039 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479431002040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 479431002041 ATP binding site [chemical binding]; other site 479431002042 putative Mg++ binding site [ion binding]; other site 479431002043 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431002044 nucleotide binding region [chemical binding]; other site 479431002045 ATP-binding site [chemical binding]; other site 479431002046 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479431002047 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479431002048 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 479431002049 Walker A/P-loop; other site 479431002050 ATP binding site [chemical binding]; other site 479431002051 Q-loop/lid; other site 479431002052 ABC transporter signature motif; other site 479431002053 Walker B; other site 479431002054 D-loop; other site 479431002055 H-loop/switch region; other site 479431002056 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479431002057 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479431002058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431002059 Walker A/P-loop; other site 479431002060 ATP binding site [chemical binding]; other site 479431002061 Q-loop/lid; other site 479431002062 ABC transporter signature motif; other site 479431002063 Walker B; other site 479431002064 D-loop; other site 479431002065 H-loop/switch region; other site 479431002066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431002067 active site 479431002068 motif I; other site 479431002069 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 479431002070 motif II; other site 479431002071 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 479431002072 Peptidase family M28; Region: Peptidase_M28; pfam04389 479431002073 metal binding site [ion binding]; metal-binding site 479431002074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431002075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431002076 active site 479431002077 phosphorylation site [posttranslational modification] 479431002078 intermolecular recognition site; other site 479431002079 dimerization interface [polypeptide binding]; other site 479431002080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431002081 DNA binding residues [nucleotide binding] 479431002082 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 479431002083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431002084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431002085 ATP binding site [chemical binding]; other site 479431002086 Mg2+ binding site [ion binding]; other site 479431002087 G-X-G motif; other site 479431002088 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 479431002089 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431002090 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431002091 hypothetical protein; Provisional; Region: PRK02237 479431002092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431002093 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 479431002094 ATP binding site [chemical binding]; other site 479431002095 putative Mg++ binding site [ion binding]; other site 479431002096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431002097 nucleotide binding region [chemical binding]; other site 479431002098 ATP-binding site [chemical binding]; other site 479431002099 DEAD/H associated; Region: DEAD_assoc; pfam08494 479431002100 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 479431002101 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 479431002102 putative DNA binding site [nucleotide binding]; other site 479431002103 catalytic residue [active] 479431002104 putative H2TH interface [polypeptide binding]; other site 479431002105 putative catalytic residues [active] 479431002106 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479431002107 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479431002108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431002109 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479431002110 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 479431002111 SelR domain; Region: SelR; pfam01641 479431002112 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 479431002113 nucleotide binding site [chemical binding]; other site 479431002114 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 479431002115 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479431002116 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479431002117 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479431002118 TIGR03086 family protein; Region: TIGR03086 479431002119 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 479431002120 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 479431002121 active site 479431002122 DNA binding site [nucleotide binding] 479431002123 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 479431002124 DNA binding site [nucleotide binding] 479431002125 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 479431002126 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 479431002127 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 479431002128 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 479431002129 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 479431002130 active site 479431002131 dimer interface [polypeptide binding]; other site 479431002132 aminotransferase; Validated; Region: PRK07777 479431002133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431002134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431002135 homodimer interface [polypeptide binding]; other site 479431002136 catalytic residue [active] 479431002137 Protein of unknown function (DUF445); Region: DUF445; pfam04286 479431002138 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431002139 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431002140 active site 479431002141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479431002142 putative acetyltransferase; Provisional; Region: PRK03624 479431002143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431002144 Coenzyme A binding pocket [chemical binding]; other site 479431002145 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 479431002146 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431002147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431002148 non-specific DNA binding site [nucleotide binding]; other site 479431002149 salt bridge; other site 479431002150 sequence-specific DNA binding site [nucleotide binding]; other site 479431002151 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 479431002152 inorganic pyrophosphatase; Provisional; Region: PRK02230 479431002153 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 479431002154 dimer interface [polypeptide binding]; other site 479431002155 substrate binding site [chemical binding]; other site 479431002156 metal binding sites [ion binding]; metal-binding site 479431002157 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 479431002158 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 479431002159 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 479431002160 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 479431002161 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 479431002162 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 479431002163 Ligand Binding Site [chemical binding]; other site 479431002164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479431002165 active site 479431002166 FtsH Extracellular; Region: FtsH_ext; pfam06480 479431002167 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 479431002168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431002169 Walker A motif; other site 479431002170 ATP binding site [chemical binding]; other site 479431002171 Walker B motif; other site 479431002172 arginine finger; other site 479431002173 Peptidase family M41; Region: Peptidase_M41; pfam01434 479431002174 GTP cyclohydrolase I; Provisional; Region: PLN03044 479431002175 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 479431002176 homodecamer interface [polypeptide binding]; other site 479431002177 active site 479431002178 putative catalytic site residues [active] 479431002179 zinc binding site [ion binding]; other site 479431002180 GTP-CH-I/GFRP interaction surface; other site 479431002181 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 479431002182 dihydropteroate synthase; Region: DHPS; TIGR01496 479431002183 substrate binding pocket [chemical binding]; other site 479431002184 dimer interface [polypeptide binding]; other site 479431002185 inhibitor binding site; inhibition site 479431002186 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 479431002187 homooctamer interface [polypeptide binding]; other site 479431002188 active site 479431002189 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 479431002190 catalytic center binding site [active] 479431002191 ATP binding site [chemical binding]; other site 479431002192 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 479431002193 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 479431002194 dimer interface [polypeptide binding]; other site 479431002195 putative anticodon binding site; other site 479431002196 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479431002197 motif 1; other site 479431002198 dimer interface [polypeptide binding]; other site 479431002199 active site 479431002200 motif 2; other site 479431002201 motif 3; other site 479431002202 Lsr2; Region: Lsr2; pfam11774 479431002203 Clp protease ATP binding subunit; Region: clpC; CHL00095 479431002204 Clp amino terminal domain; Region: Clp_N; pfam02861 479431002205 Clp amino terminal domain; Region: Clp_N; pfam02861 479431002206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431002207 Walker A motif; other site 479431002208 ATP binding site [chemical binding]; other site 479431002209 Walker B motif; other site 479431002210 arginine finger; other site 479431002211 UvrB/uvrC motif; Region: UVR; pfam02151 479431002212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431002213 Walker A motif; other site 479431002214 ATP binding site [chemical binding]; other site 479431002215 Walker B motif; other site 479431002216 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 479431002217 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431002218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431002219 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431002220 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 479431002221 Helix-turn-helix domain; Region: HTH_38; pfam13936 479431002222 Integrase core domain; Region: rve; pfam00665 479431002223 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 479431002224 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 479431002225 minor groove reading motif; other site 479431002226 helix-hairpin-helix signature motif; other site 479431002227 active site 479431002228 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 479431002229 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 479431002230 active site clefts [active] 479431002231 zinc binding site [ion binding]; other site 479431002232 dimer interface [polypeptide binding]; other site 479431002233 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 479431002234 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 479431002235 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 479431002236 DNA repair protein RadA; Provisional; Region: PRK11823 479431002237 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 479431002238 Walker A motif; other site 479431002239 ATP binding site [chemical binding]; other site 479431002240 Walker B motif; other site 479431002241 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 479431002242 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 479431002243 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 479431002244 substrate binding site; other site 479431002245 dimer interface; other site 479431002246 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 479431002247 homotrimer interaction site [polypeptide binding]; other site 479431002248 zinc binding site [ion binding]; other site 479431002249 CDP-binding sites; other site 479431002250 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 479431002251 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 479431002252 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431002253 NAD(P) binding site [chemical binding]; other site 479431002254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431002255 acyl-coenzyme A oxidase; Region: PLN02526 479431002256 active site 479431002257 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 479431002258 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479431002259 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479431002260 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 479431002261 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479431002262 substrate binding site [chemical binding]; other site 479431002263 oxyanion hole (OAH) forming residues; other site 479431002264 trimer interface [polypeptide binding]; other site 479431002265 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431002266 acyl-coenzyme A oxidase; Region: PLN02526 479431002267 active site 479431002268 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 479431002269 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479431002270 dimer interface [polypeptide binding]; other site 479431002271 active site 479431002272 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 479431002273 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 479431002274 acyl-activating enzyme (AAE) consensus motif; other site 479431002275 putative AMP binding site [chemical binding]; other site 479431002276 putative active site [active] 479431002277 putative CoA binding site [chemical binding]; other site 479431002278 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 479431002279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431002280 NAD(P) binding site [chemical binding]; other site 479431002281 active site 479431002282 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 479431002283 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 479431002284 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 479431002285 active site 479431002286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479431002287 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 479431002288 substrate binding site [chemical binding]; other site 479431002289 oxyanion hole (OAH) forming residues; other site 479431002290 trimer interface [polypeptide binding]; other site 479431002291 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431002292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431002293 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 479431002294 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479431002295 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 479431002296 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 479431002297 Domain of unknown function (DUF385); Region: DUF385; pfam04075 479431002298 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479431002299 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 479431002300 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 479431002301 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 479431002302 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 479431002303 active site turn [active] 479431002304 phosphorylation site [posttranslational modification] 479431002305 transcriptional antiterminator BglG; Provisional; Region: PRK09772 479431002306 CAT RNA binding domain; Region: CAT_RBD; smart01061 479431002307 PRD domain; Region: PRD; pfam00874 479431002308 PRD domain; Region: PRD; pfam00874 479431002309 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 479431002310 beta-galactosidase; Region: BGL; TIGR03356 479431002311 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 479431002312 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 479431002313 active site turn [active] 479431002314 phosphorylation site [posttranslational modification] 479431002315 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 479431002316 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 479431002317 HPr interaction site; other site 479431002318 glycerol kinase (GK) interaction site [polypeptide binding]; other site 479431002319 active site 479431002320 phosphorylation site [posttranslational modification] 479431002321 Integrase core domain; Region: rve; pfam00665 479431002322 Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965 479431002323 Thioredoxin; Region: Thioredoxin_4; pfam13462 479431002324 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 479431002325 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479431002326 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479431002327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431002328 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479431002329 Walker A/P-loop; other site 479431002330 ATP binding site [chemical binding]; other site 479431002331 Q-loop/lid; other site 479431002332 ABC transporter signature motif; other site 479431002333 Walker B; other site 479431002334 D-loop; other site 479431002335 H-loop/switch region; other site 479431002336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431002337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431002338 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479431002339 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 479431002340 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 479431002341 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 479431002342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431002343 putative substrate translocation pore; other site 479431002344 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 479431002345 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 479431002346 [4Fe-4S] binding site [ion binding]; other site 479431002347 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479431002348 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479431002349 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479431002350 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 479431002351 molybdopterin cofactor binding site; other site 479431002352 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 479431002353 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 479431002354 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 479431002355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431002356 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431002357 Winged helix-turn helix; Region: HTH_29; pfam13551 479431002358 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 479431002359 Helix-turn-helix domain; Region: HTH_38; pfam13936 479431002360 Integrase core domain; Region: rve; pfam00665 479431002361 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 479431002362 active sites [active] 479431002363 tetramer interface [polypeptide binding]; other site 479431002364 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 479431002365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431002366 Walker A/P-loop; other site 479431002367 ATP binding site [chemical binding]; other site 479431002368 Q-loop/lid; other site 479431002369 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479431002370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431002371 Walker A/P-loop; other site 479431002372 ATP binding site [chemical binding]; other site 479431002373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431002374 ABC transporter signature motif; other site 479431002375 Walker B; other site 479431002376 D-loop; other site 479431002377 H-loop/switch region; other site 479431002378 DNA binding domain, excisionase family; Region: excise; TIGR01764 479431002379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431002380 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479431002381 NAD(P) binding site [chemical binding]; other site 479431002382 active site 479431002383 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 479431002384 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479431002385 putative acyl-acceptor binding pocket; other site 479431002386 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 479431002387 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 479431002388 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 479431002389 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431002390 acyl-activating enzyme (AAE) consensus motif; other site 479431002391 active site 479431002392 AMP binding site [chemical binding]; other site 479431002393 CoA binding site [chemical binding]; other site 479431002394 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 479431002395 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 479431002396 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 479431002397 CoA binding domain; Region: CoA_binding; pfam02629 479431002398 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 479431002399 active site 479431002400 homodimer interface [polypeptide binding]; other site 479431002401 SAM binding site [chemical binding]; other site 479431002402 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 479431002403 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 479431002404 active site 479431002405 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 479431002406 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431002407 catalytic core [active] 479431002408 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 479431002409 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 479431002410 catalytic residues [active] 479431002411 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 479431002412 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 479431002413 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 479431002414 ResB-like family; Region: ResB; pfam05140 479431002415 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 479431002416 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 479431002417 DNA binding residues [nucleotide binding] 479431002418 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 479431002419 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 479431002420 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 479431002421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431002422 catalytic residue [active] 479431002423 glutamate carboxypeptidase; Reviewed; Region: PRK06133 479431002424 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 479431002425 metal binding site [ion binding]; metal-binding site 479431002426 dimer interface [polypeptide binding]; other site 479431002427 Uncharacterized conserved protein [Function unknown]; Region: COG3375 479431002428 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 479431002429 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 479431002430 active site 479431002431 octamer interface [polypeptide binding]; other site 479431002432 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 479431002433 UbiA prenyltransferase family; Region: UbiA; pfam01040 479431002434 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 479431002435 active site 479431002436 SUMO-1 interface [polypeptide binding]; other site 479431002437 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431002438 acyl-activating enzyme (AAE) consensus motif; other site 479431002439 AMP binding site [chemical binding]; other site 479431002440 active site 479431002441 CoA binding site [chemical binding]; other site 479431002442 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479431002443 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 479431002444 substrate binding site [chemical binding]; other site 479431002445 oxyanion hole (OAH) forming residues; other site 479431002446 trimer interface [polypeptide binding]; other site 479431002447 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 479431002448 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 479431002449 active site 479431002450 metal binding site [ion binding]; metal-binding site 479431002451 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 479431002452 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 479431002453 Methyltransferase domain; Region: Methyltransf_12; pfam08242 479431002454 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 479431002455 CoenzymeA binding site [chemical binding]; other site 479431002456 subunit interaction site [polypeptide binding]; other site 479431002457 PHB binding site; other site 479431002458 Predicted transcriptional regulators [Transcription]; Region: COG1733 479431002459 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479431002460 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479431002461 catalytic residues [active] 479431002462 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479431002463 DNA binding residues [nucleotide binding] 479431002464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431002465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431002466 active site 479431002467 phosphorylation site [posttranslational modification] 479431002468 intermolecular recognition site; other site 479431002469 dimerization interface [polypeptide binding]; other site 479431002470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431002471 DNA binding site [nucleotide binding] 479431002472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431002473 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479431002474 dimerization interface [polypeptide binding]; other site 479431002475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431002476 dimer interface [polypeptide binding]; other site 479431002477 phosphorylation site [posttranslational modification] 479431002478 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479431002479 Mg2+ binding site [ion binding]; other site 479431002480 G-X-G motif; other site 479431002481 O-succinylbenzoate synthase; Provisional; Region: PRK02901 479431002482 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 479431002483 metal binding site [ion binding]; metal-binding site 479431002484 substrate binding pocket [chemical binding]; other site 479431002485 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 479431002486 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479431002487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431002488 DNA-binding site [nucleotide binding]; DNA binding site 479431002489 UTRA domain; Region: UTRA; pfam07702 479431002490 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 479431002491 SnoaL-like domain; Region: SnoaL_3; pfam13474 479431002492 Hemerythrin-like domain; Region: Hr-like; cd12108 479431002493 Fe binding site [ion binding]; other site 479431002494 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431002495 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431002496 DNA binding residues [nucleotide binding] 479431002497 dimerization interface [polypeptide binding]; other site 479431002498 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431002499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431002500 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431002501 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 479431002502 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 479431002503 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 479431002504 active site turn [active] 479431002505 phosphorylation site [posttranslational modification] 479431002506 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 479431002507 glycerol kinase (GK) interaction site [polypeptide binding]; other site 479431002508 HPr interaction site; other site 479431002509 active site 479431002510 phosphorylation site [posttranslational modification] 479431002511 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 479431002512 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 479431002513 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 479431002514 active site 479431002515 trimer interface [polypeptide binding]; other site 479431002516 allosteric site; other site 479431002517 active site lid [active] 479431002518 hexamer (dimer of trimers) interface [polypeptide binding]; other site 479431002519 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 479431002520 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431002521 active site 479431002522 MarR family; Region: MarR_2; pfam12802 479431002523 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431002524 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 479431002525 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 479431002526 PYR/PP interface [polypeptide binding]; other site 479431002527 dimer interface [polypeptide binding]; other site 479431002528 TPP binding site [chemical binding]; other site 479431002529 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 479431002530 TPP-binding site [chemical binding]; other site 479431002531 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479431002532 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431002533 active site 479431002534 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 479431002535 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 479431002536 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431002537 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 479431002538 CoA-transferase family III; Region: CoA_transf_3; pfam02515 479431002539 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 479431002540 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 479431002541 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 479431002542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431002543 S-adenosylmethionine binding site [chemical binding]; other site 479431002544 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 479431002545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479431002546 NADH dehydrogenase subunit A; Validated; Region: PRK07928 479431002547 NADH dehydrogenase subunit B; Validated; Region: PRK06411 479431002548 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 479431002549 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 479431002550 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 479431002551 NADH dehydrogenase subunit D; Validated; Region: PRK06075 479431002552 NADH dehydrogenase subunit E; Validated; Region: PRK07539 479431002553 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 479431002554 putative dimer interface [polypeptide binding]; other site 479431002555 [2Fe-2S] cluster binding site [ion binding]; other site 479431002556 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 479431002557 SLBB domain; Region: SLBB; pfam10531 479431002558 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 479431002559 NADH dehydrogenase subunit G; Validated; Region: PRK07860 479431002560 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479431002561 catalytic loop [active] 479431002562 iron binding site [ion binding]; other site 479431002563 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 479431002564 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479431002565 molybdopterin cofactor binding site; other site 479431002566 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 479431002567 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 479431002568 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 479431002569 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 479431002570 4Fe-4S binding domain; Region: Fer4; pfam00037 479431002571 4Fe-4S binding domain; Region: Fer4; pfam00037 479431002572 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 479431002573 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 479431002574 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 479431002575 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 479431002576 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 479431002577 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479431002578 hydrogenase 4 subunit D; Validated; Region: PRK06525 479431002579 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479431002580 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 479431002581 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479431002582 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 479431002583 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 479431002584 substrate binding pocket [chemical binding]; other site 479431002585 chain length determination region; other site 479431002586 substrate-Mg2+ binding site; other site 479431002587 catalytic residues [active] 479431002588 aspartate-rich region 1; other site 479431002589 active site lid residues [active] 479431002590 aspartate-rich region 2; other site 479431002591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431002592 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431002593 sequence-specific DNA binding site [nucleotide binding]; other site 479431002594 salt bridge; other site 479431002595 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479431002596 active site 479431002597 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 479431002598 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 479431002599 homodimer interface [polypeptide binding]; other site 479431002600 putative substrate binding pocket [chemical binding]; other site 479431002601 diiron center [ion binding]; other site 479431002602 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479431002603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431002604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431002605 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 479431002606 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 479431002607 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479431002608 putative hydrophobic ligand binding site [chemical binding]; other site 479431002609 malate synthase A; Region: malate_syn_A; TIGR01344 479431002610 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 479431002611 active site 479431002612 isocitrate lyase; Provisional; Region: PRK15063 479431002613 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 479431002614 tetramer interface [polypeptide binding]; other site 479431002615 active site 479431002616 Mg2+/Mn2+ binding site [ion binding]; other site 479431002617 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431002618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431002619 non-specific DNA binding site [nucleotide binding]; other site 479431002620 salt bridge; other site 479431002621 sequence-specific DNA binding site [nucleotide binding]; other site 479431002622 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 479431002623 Domain of unknown function (DUF955); Region: DUF955; pfam06114 479431002624 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 479431002625 putative hydrophobic ligand binding site [chemical binding]; other site 479431002626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431002627 putative DNA binding site [nucleotide binding]; other site 479431002628 dimerization interface [polypeptide binding]; other site 479431002629 putative Zn2+ binding site [ion binding]; other site 479431002630 Predicted permeases [General function prediction only]; Region: RarD; COG2962 479431002631 EamA-like transporter family; Region: EamA; cl17759 479431002632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431002633 sequence-specific DNA binding site [nucleotide binding]; other site 479431002634 salt bridge; other site 479431002635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 479431002636 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 479431002637 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479431002638 GAF domain; Region: GAF_3; pfam13492 479431002639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431002640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431002641 metal binding site [ion binding]; metal-binding site 479431002642 active site 479431002643 I-site; other site 479431002644 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 479431002645 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 479431002646 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 479431002647 active site 479431002648 catalytic site [active] 479431002649 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 479431002650 active site 479431002651 catalytic site [active] 479431002652 aspartate aminotransferase; Provisional; Region: PRK05764 479431002653 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431002654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431002655 homodimer interface [polypeptide binding]; other site 479431002656 catalytic residue [active] 479431002657 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 479431002658 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 479431002659 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 479431002660 putative homodimer interface [polypeptide binding]; other site 479431002661 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 479431002662 heterodimer interface [polypeptide binding]; other site 479431002663 homodimer interface [polypeptide binding]; other site 479431002664 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 479431002665 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 479431002666 23S rRNA interface [nucleotide binding]; other site 479431002667 L7/L12 interface [polypeptide binding]; other site 479431002668 putative thiostrepton binding site; other site 479431002669 L25 interface [polypeptide binding]; other site 479431002670 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 479431002671 mRNA/rRNA interface [nucleotide binding]; other site 479431002672 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 479431002673 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 479431002674 Catalytic site [active] 479431002675 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 479431002676 23S rRNA interface [nucleotide binding]; other site 479431002677 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 479431002678 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 479431002679 core dimer interface [polypeptide binding]; other site 479431002680 peripheral dimer interface [polypeptide binding]; other site 479431002681 L10 interface [polypeptide binding]; other site 479431002682 L11 interface [polypeptide binding]; other site 479431002683 putative EF-Tu interaction site [polypeptide binding]; other site 479431002684 putative EF-G interaction site [polypeptide binding]; other site 479431002685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431002686 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479431002687 Walker A motif; other site 479431002688 ATP binding site [chemical binding]; other site 479431002689 Walker B motif; other site 479431002690 arginine finger; other site 479431002691 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 479431002692 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002693 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002694 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002695 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002696 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002697 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002698 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002699 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002700 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 479431002701 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 479431002702 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002703 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002704 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431002705 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431002706 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 479431002707 catalytic site [active] 479431002708 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 479431002709 Orientia OTT_1508-like deaminase; Region: OTT_1508_deam; pfam14441 479431002710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431002711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431002712 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479431002713 putative dimerization interface [polypeptide binding]; other site 479431002714 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 479431002715 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479431002716 NAD(P) binding site [chemical binding]; other site 479431002717 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 479431002718 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 479431002719 substrate-cofactor binding pocket; other site 479431002720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431002721 catalytic residue [active] 479431002722 Predicted membrane protein [Function unknown]; Region: COG2860 479431002723 UPF0126 domain; Region: UPF0126; pfam03458 479431002724 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 479431002725 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 479431002726 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 479431002727 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 479431002728 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 479431002729 Cysteine-rich domain; Region: CCG; pfam02754 479431002730 Cysteine-rich domain; Region: CCG; pfam02754 479431002731 L-lactate permease; Region: Lactate_perm; cl00701 479431002732 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 479431002733 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431002734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431002735 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479431002736 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 479431002737 Citrate transporter; Region: CitMHS; pfam03600 479431002738 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 479431002739 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 479431002740 CoA-transferase family III; Region: CoA_transf_3; pfam02515 479431002741 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 479431002742 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 479431002743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431002744 active site 479431002745 phosphorylation site [posttranslational modification] 479431002746 intermolecular recognition site; other site 479431002747 dimerization interface [polypeptide binding]; other site 479431002748 Transcriptional regulator; Region: CitT; pfam12431 479431002749 HTH domain; Region: HTH_11; cl17392 479431002750 PAS domain; Region: PAS; smart00091 479431002751 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 479431002752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431002753 ATP binding site [chemical binding]; other site 479431002754 Mg2+ binding site [ion binding]; other site 479431002755 G-X-G motif; other site 479431002756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 479431002757 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479431002758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431002759 DNA-binding site [nucleotide binding]; DNA binding site 479431002760 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431002761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431002762 homodimer interface [polypeptide binding]; other site 479431002763 catalytic residue [active] 479431002764 FOG: CBS domain [General function prediction only]; Region: COG0517 479431002765 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 479431002766 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431002767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431002768 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479431002769 dimerization interface [polypeptide binding]; other site 479431002770 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431002771 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431002772 phage tail protein domain; Region: tail_TIGR02242 479431002773 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 479431002774 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 479431002775 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 479431002776 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 479431002777 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 479431002778 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479431002779 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 479431002780 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 479431002781 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 479431002782 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 479431002783 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 479431002784 Septum formation; Region: Septum_form; pfam13845 479431002785 AAA ATPase domain; Region: AAA_16; pfam13191 479431002786 Predicted ATPase [General function prediction only]; Region: COG3903 479431002787 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479431002788 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431002789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431002790 DNA binding residues [nucleotide binding] 479431002791 dimerization interface [polypeptide binding]; other site 479431002792 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 479431002793 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 479431002794 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 479431002795 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 479431002796 RPB1 interaction site [polypeptide binding]; other site 479431002797 RPB10 interaction site [polypeptide binding]; other site 479431002798 RPB11 interaction site [polypeptide binding]; other site 479431002799 RPB3 interaction site [polypeptide binding]; other site 479431002800 RPB12 interaction site [polypeptide binding]; other site 479431002801 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 479431002802 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 479431002803 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 479431002804 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 479431002805 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 479431002806 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 479431002807 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 479431002808 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 479431002809 DNA binding site [nucleotide binding] 479431002810 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 479431002811 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 479431002812 CopC domain; Region: CopC; pfam04234 479431002813 YtkA-like; Region: YtkA; pfam13115 479431002814 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 479431002815 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479431002816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431002817 NAD(P) binding site [chemical binding]; other site 479431002818 active site 479431002819 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 479431002820 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479431002821 intersubunit interface [polypeptide binding]; other site 479431002822 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 479431002823 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 479431002824 dimer interface [polypeptide binding]; other site 479431002825 putative PBP binding regions; other site 479431002826 ABC-ATPase subunit interface; other site 479431002827 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 479431002828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431002829 Walker A/P-loop; other site 479431002830 ATP binding site [chemical binding]; other site 479431002831 Q-loop/lid; other site 479431002832 ABC transporter signature motif; other site 479431002833 Walker B; other site 479431002834 D-loop; other site 479431002835 H-loop/switch region; other site 479431002836 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 479431002837 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 479431002838 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 479431002839 ligand binding site [chemical binding]; other site 479431002840 homodimer interface [polypeptide binding]; other site 479431002841 NAD(P) binding site [chemical binding]; other site 479431002842 trimer interface B [polypeptide binding]; other site 479431002843 trimer interface A [polypeptide binding]; other site 479431002844 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 479431002845 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 479431002846 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 479431002847 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 479431002848 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 479431002849 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 479431002850 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 479431002851 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 479431002852 putative active site [active] 479431002853 putative dimer interface [polypeptide binding]; other site 479431002854 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 479431002855 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 479431002856 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479431002857 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479431002858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431002859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431002860 DNA binding residues [nucleotide binding] 479431002861 Putative zinc-finger; Region: zf-HC2; pfam13490 479431002862 Protein of unknown function (DUF419); Region: DUF419; cl15265 479431002863 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 479431002864 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479431002865 E3 interaction surface; other site 479431002866 lipoyl attachment site [posttranslational modification]; other site 479431002867 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431002868 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479431002869 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 479431002870 alpha subunit interface [polypeptide binding]; other site 479431002871 TPP binding site [chemical binding]; other site 479431002872 heterodimer interface [polypeptide binding]; other site 479431002873 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479431002874 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 479431002875 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479431002876 tetramer interface [polypeptide binding]; other site 479431002877 TPP-binding site [chemical binding]; other site 479431002878 heterodimer interface [polypeptide binding]; other site 479431002879 phosphorylation loop region [posttranslational modification] 479431002880 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 479431002881 acetoin reductases; Region: 23BDH; TIGR02415 479431002882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431002883 NAD(P) binding site [chemical binding]; other site 479431002884 active site 479431002885 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 479431002886 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431002887 putative NAD(P) binding site [chemical binding]; other site 479431002888 catalytic Zn binding site [ion binding]; other site 479431002889 Ribosomal protein S26e; Region: Ribosomal_S26e; cl01993 479431002890 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479431002891 DNA binding site [nucleotide binding] 479431002892 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 479431002893 heme-binding site [chemical binding]; other site 479431002894 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 479431002895 HsdM N-terminal domain; Region: HsdM_N; pfam12161 479431002896 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 479431002897 Methyltransferase domain; Region: Methyltransf_26; pfam13659 479431002898 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 479431002899 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 479431002900 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 479431002901 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 479431002902 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 479431002903 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 479431002904 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 479431002905 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 479431002906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431002907 ATP binding site [chemical binding]; other site 479431002908 putative Mg++ binding site [ion binding]; other site 479431002909 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 479431002910 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 479431002911 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 479431002912 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 479431002913 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 479431002914 Part of AAA domain; Region: AAA_19; pfam13245 479431002915 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 479431002916 AAA domain; Region: AAA_12; pfam13087 479431002917 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 479431002918 putative active site [active] 479431002919 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 479431002920 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 479431002921 metabolite-proton symporter; Region: 2A0106; TIGR00883 479431002922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431002923 putative substrate translocation pore; other site 479431002924 Coenzyme A transferase; Region: CoA_trans; cl17247 479431002925 Coenzyme A transferase; Region: CoA_trans; cl17247 479431002926 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 479431002927 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431002928 substrate binding site [chemical binding]; other site 479431002929 ATP binding site [chemical binding]; other site 479431002930 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 479431002931 S17 interaction site [polypeptide binding]; other site 479431002932 S8 interaction site; other site 479431002933 16S rRNA interaction site [nucleotide binding]; other site 479431002934 streptomycin interaction site [chemical binding]; other site 479431002935 23S rRNA interaction site [nucleotide binding]; other site 479431002936 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 479431002937 30S ribosomal protein S7; Validated; Region: PRK05302 479431002938 elongation factor G; Reviewed; Region: PRK00007 479431002939 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 479431002940 G1 box; other site 479431002941 putative GEF interaction site [polypeptide binding]; other site 479431002942 GTP/Mg2+ binding site [chemical binding]; other site 479431002943 Switch I region; other site 479431002944 G2 box; other site 479431002945 G3 box; other site 479431002946 Switch II region; other site 479431002947 G4 box; other site 479431002948 G5 box; other site 479431002949 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 479431002950 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 479431002951 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 479431002952 elongation factor Tu; Reviewed; Region: PRK00049 479431002953 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 479431002954 G1 box; other site 479431002955 GEF interaction site [polypeptide binding]; other site 479431002956 GTP/Mg2+ binding site [chemical binding]; other site 479431002957 Switch I region; other site 479431002958 G2 box; other site 479431002959 G3 box; other site 479431002960 Switch II region; other site 479431002961 G4 box; other site 479431002962 G5 box; other site 479431002963 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 479431002964 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 479431002965 Antibiotic Binding Site [chemical binding]; other site 479431002966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 479431002967 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 479431002968 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 479431002969 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 479431002970 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 479431002971 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 479431002972 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 479431002973 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 479431002974 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 479431002975 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 479431002976 putative translocon binding site; other site 479431002977 protein-rRNA interface [nucleotide binding]; other site 479431002978 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 479431002979 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 479431002980 G-X-X-G motif; other site 479431002981 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 479431002982 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 479431002983 23S rRNA interface [nucleotide binding]; other site 479431002984 5S rRNA interface [nucleotide binding]; other site 479431002985 putative antibiotic binding site [chemical binding]; other site 479431002986 L25 interface [polypeptide binding]; other site 479431002987 L27 interface [polypeptide binding]; other site 479431002988 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 479431002989 23S rRNA interface [nucleotide binding]; other site 479431002990 putative translocon interaction site; other site 479431002991 signal recognition particle (SRP54) interaction site; other site 479431002992 L23 interface [polypeptide binding]; other site 479431002993 trigger factor interaction site; other site 479431002994 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 479431002995 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 479431002996 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 479431002997 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 479431002998 RNA binding site [nucleotide binding]; other site 479431002999 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 479431003000 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 479431003001 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 479431003002 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 479431003003 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 479431003004 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 479431003005 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 479431003006 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 479431003007 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 479431003008 5S rRNA interface [nucleotide binding]; other site 479431003009 L27 interface [polypeptide binding]; other site 479431003010 23S rRNA interface [nucleotide binding]; other site 479431003011 L5 interface [polypeptide binding]; other site 479431003012 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 479431003013 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 479431003014 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 479431003015 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 479431003016 23S rRNA binding site [nucleotide binding]; other site 479431003017 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 479431003018 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 479431003019 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431003020 Ligand Binding Site [chemical binding]; other site 479431003021 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431003022 Ligand Binding Site [chemical binding]; other site 479431003023 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 479431003024 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 479431003025 nucleotide binding site/active site [active] 479431003026 HIT family signature motif; other site 479431003027 catalytic residue [active] 479431003028 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 479431003029 SecY translocase; Region: SecY; pfam00344 479431003030 adenylate kinase; Reviewed; Region: adk; PRK00279 479431003031 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 479431003032 AMP-binding site [chemical binding]; other site 479431003033 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 479431003034 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479431003035 active site 479431003036 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 479431003037 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 479431003038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 479431003039 Histidine kinase; Region: His_kinase; pfam06580 479431003040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431003041 ATP binding site [chemical binding]; other site 479431003042 Mg2+ binding site [ion binding]; other site 479431003043 G-X-G motif; other site 479431003044 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 479431003045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431003046 active site 479431003047 phosphorylation site [posttranslational modification] 479431003048 intermolecular recognition site; other site 479431003049 dimerization interface [polypeptide binding]; other site 479431003050 LytTr DNA-binding domain; Region: LytTR; smart00850 479431003051 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 479431003052 Na binding site [ion binding]; other site 479431003053 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 479431003054 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 479431003055 nucleoside/Zn binding site; other site 479431003056 dimer interface [polypeptide binding]; other site 479431003057 catalytic motif [active] 479431003058 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 479431003059 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 479431003060 FAD binding pocket [chemical binding]; other site 479431003061 FAD binding motif [chemical binding]; other site 479431003062 phosphate binding motif [ion binding]; other site 479431003063 NAD binding pocket [chemical binding]; other site 479431003064 Protein of unknown function, DUF485; Region: DUF485; pfam04341 479431003065 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 479431003066 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 479431003067 Na binding site [ion binding]; other site 479431003068 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 479431003069 PAS domain; Region: PAS; smart00091 479431003070 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 479431003071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431003072 active site 479431003073 phosphorylation site [posttranslational modification] 479431003074 intermolecular recognition site; other site 479431003075 dimerization interface [polypeptide binding]; other site 479431003076 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 479431003077 active site 479431003078 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 479431003079 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 479431003080 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 479431003081 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 479431003082 rRNA binding site [nucleotide binding]; other site 479431003083 predicted 30S ribosome binding site; other site 479431003084 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 479431003085 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 479431003086 30S ribosomal protein S13; Region: bact_S13; TIGR03631 479431003087 30S ribosomal protein S11; Validated; Region: PRK05309 479431003088 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 479431003089 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 479431003090 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 479431003091 RNA binding surface [nucleotide binding]; other site 479431003092 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 479431003093 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 479431003094 alphaNTD homodimer interface [polypeptide binding]; other site 479431003095 alphaNTD - beta interaction site [polypeptide binding]; other site 479431003096 alphaNTD - beta' interaction site [polypeptide binding]; other site 479431003097 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 479431003098 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 479431003099 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 479431003100 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 479431003101 dimerization interface 3.5A [polypeptide binding]; other site 479431003102 active site 479431003103 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 479431003104 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 479431003105 Sulfate transporter family; Region: Sulfate_transp; pfam00916 479431003106 Sulfate transporter family; Region: Sulfate_transp; pfam00916 479431003107 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 479431003108 23S rRNA interface [nucleotide binding]; other site 479431003109 L3 interface [polypeptide binding]; other site 479431003110 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 479431003111 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 479431003112 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 479431003113 active site 479431003114 substrate binding site [chemical binding]; other site 479431003115 metal binding site [ion binding]; metal-binding site 479431003116 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479431003117 Ycf46; Provisional; Region: ycf46; CHL00195 479431003118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431003119 Walker A motif; other site 479431003120 ATP binding site [chemical binding]; other site 479431003121 Walker B motif; other site 479431003122 arginine finger; other site 479431003123 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479431003124 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431003125 MULE transposase domain; Region: MULE; pfam10551 479431003126 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479431003127 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431003128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431003129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431003130 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431003131 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 479431003132 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 479431003133 glutaminase active site [active] 479431003134 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 479431003135 dimer interface [polypeptide binding]; other site 479431003136 active site 479431003137 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 479431003138 dimer interface [polypeptide binding]; other site 479431003139 active site 479431003140 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 479431003141 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 479431003142 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 479431003143 putative substrate binding site [chemical binding]; other site 479431003144 putative ATP binding site [chemical binding]; other site 479431003145 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 479431003146 alanine racemase; Reviewed; Region: alr; PRK00053 479431003147 active site 479431003148 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479431003149 dimer interface [polypeptide binding]; other site 479431003150 substrate binding site [chemical binding]; other site 479431003151 catalytic residues [active] 479431003152 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431003153 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 479431003154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431003155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431003156 active site 479431003157 phosphorylation site [posttranslational modification] 479431003158 intermolecular recognition site; other site 479431003159 dimerization interface [polypeptide binding]; other site 479431003160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431003161 DNA binding site [nucleotide binding] 479431003162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431003163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431003164 dimer interface [polypeptide binding]; other site 479431003165 phosphorylation site [posttranslational modification] 479431003166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431003167 ATP binding site [chemical binding]; other site 479431003168 Mg2+ binding site [ion binding]; other site 479431003169 G-X-G motif; other site 479431003170 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431003171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431003172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431003173 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431003174 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431003175 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431003176 Electron transfer DM13; Region: DM13; pfam10517 479431003177 GtrA-like protein; Region: GtrA; pfam04138 479431003178 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431003179 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431003180 DNA binding site [nucleotide binding] 479431003181 domain linker motif; other site 479431003182 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431003183 dimerization interface [polypeptide binding]; other site 479431003184 ligand binding site [chemical binding]; other site 479431003185 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 479431003186 Glycoprotease family; Region: Peptidase_M22; pfam00814 479431003187 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 479431003188 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 479431003189 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 479431003190 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 479431003191 oligomerisation interface [polypeptide binding]; other site 479431003192 mobile loop; other site 479431003193 roof hairpin; other site 479431003194 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 479431003195 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 479431003196 ring oligomerisation interface [polypeptide binding]; other site 479431003197 ATP/Mg binding site [chemical binding]; other site 479431003198 stacking interactions; other site 479431003199 hinge regions; other site 479431003200 Transcription factor WhiB; Region: Whib; pfam02467 479431003201 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431003202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 479431003203 active site 479431003204 phosphorylation site [posttranslational modification] 479431003205 intermolecular recognition site; other site 479431003206 dimerization interface [polypeptide binding]; other site 479431003207 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431003208 DNA binding residues [nucleotide binding] 479431003209 dimerization interface [polypeptide binding]; other site 479431003210 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 479431003211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431003212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431003213 DNA binding residues [nucleotide binding] 479431003214 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 479431003215 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 479431003216 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 479431003217 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 479431003218 active site 479431003219 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 479431003220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431003221 ATP binding site [chemical binding]; other site 479431003222 Walker A motif; other site 479431003223 Walker B motif; other site 479431003224 arginine finger; other site 479431003225 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 479431003226 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431003227 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431003228 active site 479431003229 DNA binding site [nucleotide binding] 479431003230 Int/Topo IB signature motif; other site 479431003231 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479431003232 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431003233 active site 479431003234 catalytic residues [active] 479431003235 DNA binding site [nucleotide binding] 479431003236 Int/Topo IB signature motif; other site 479431003237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 479431003238 putative transposase OrfB; Reviewed; Region: PHA02517 479431003239 HTH-like domain; Region: HTH_21; pfam13276 479431003240 Integrase core domain; Region: rve; pfam00665 479431003241 Integrase core domain; Region: rve_3; pfam13683 479431003242 Transposase domain (DUF772); Region: DUF772; pfam05598 479431003243 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431003244 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431003245 putative transposase OrfB; Reviewed; Region: PHA02517 479431003246 HTH-like domain; Region: HTH_21; pfam13276 479431003247 Integrase core domain; Region: rve; pfam00665 479431003248 Integrase core domain; Region: rve_3; pfam13683 479431003249 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 479431003250 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 479431003251 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 479431003252 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 479431003253 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 479431003254 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 479431003255 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431003256 MULE transposase domain; Region: MULE; pfam10551 479431003257 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 479431003258 putative active site [active] 479431003259 putative NTP binding site [chemical binding]; other site 479431003260 putative nucleic acid binding site [nucleotide binding]; other site 479431003261 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 479431003262 putative transposase OrfB; Reviewed; Region: PHA02517 479431003263 HTH-like domain; Region: HTH_21; pfam13276 479431003264 Integrase core domain; Region: rve; pfam00665 479431003265 Integrase core domain; Region: rve_3; pfam13683 479431003266 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 479431003267 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431003268 active site 479431003269 DNA binding site [nucleotide binding] 479431003270 Int/Topo IB signature motif; other site 479431003271 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431003272 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431003273 active site 479431003274 catalytic residues [active] 479431003275 DNA binding site [nucleotide binding] 479431003276 Int/Topo IB signature motif; other site 479431003277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431003278 Transposase; Region: HTH_Tnp_1; cl17663 479431003279 putative transposase OrfB; Reviewed; Region: PHA02517 479431003280 HTH-like domain; Region: HTH_21; pfam13276 479431003281 Integrase core domain; Region: rve; pfam00665 479431003282 Integrase core domain; Region: rve_3; cl15866 479431003283 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 479431003284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431003285 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431003286 CRISPR-associated protein; Region: TIGR03986 479431003287 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 479431003288 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 479431003289 phosphate binding site [ion binding]; other site 479431003290 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 479431003291 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 479431003292 oligomer interface [polypeptide binding]; other site 479431003293 metal binding site [ion binding]; metal-binding site 479431003294 metal binding site [ion binding]; metal-binding site 479431003295 putative Cl binding site [ion binding]; other site 479431003296 aspartate ring; other site 479431003297 basic sphincter; other site 479431003298 hydrophobic gate; other site 479431003299 periplasmic entrance; other site 479431003300 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 479431003301 GMP synthase; Reviewed; Region: guaA; PRK00074 479431003302 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 479431003303 AMP/PPi binding site [chemical binding]; other site 479431003304 candidate oxyanion hole; other site 479431003305 catalytic triad [active] 479431003306 potential glutamine specificity residues [chemical binding]; other site 479431003307 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 479431003308 ATP Binding subdomain [chemical binding]; other site 479431003309 Ligand Binding sites [chemical binding]; other site 479431003310 Dimerization subdomain; other site 479431003311 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 479431003312 PspC domain; Region: PspC; pfam04024 479431003313 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 479431003314 PspC domain; Region: PspC; pfam04024 479431003315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431003316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431003317 ATP binding site [chemical binding]; other site 479431003318 Mg2+ binding site [ion binding]; other site 479431003319 G-X-G motif; other site 479431003320 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431003321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431003322 active site 479431003323 phosphorylation site [posttranslational modification] 479431003324 intermolecular recognition site; other site 479431003325 dimerization interface [polypeptide binding]; other site 479431003326 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431003327 DNA binding residues [nucleotide binding] 479431003328 dimerization interface [polypeptide binding]; other site 479431003329 hypothetical protein; Provisional; Region: PRK07857 479431003330 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 479431003331 Part of AAA domain; Region: AAA_19; pfam13245 479431003332 Family description; Region: UvrD_C_2; pfam13538 479431003333 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 479431003334 B12 binding site [chemical binding]; other site 479431003335 cobalt ligand [ion binding]; other site 479431003336 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 479431003337 nudix motif; other site 479431003338 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 479431003339 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 479431003340 CoA-ligase; Region: Ligase_CoA; pfam00549 479431003341 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 479431003342 CoA binding domain; Region: CoA_binding; smart00881 479431003343 CoA-ligase; Region: Ligase_CoA; pfam00549 479431003344 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431003345 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479431003346 metal ion-dependent adhesion site (MIDAS); other site 479431003347 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 479431003348 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 479431003349 active site 479431003350 substrate binding site [chemical binding]; other site 479431003351 cosubstrate binding site; other site 479431003352 catalytic site [active] 479431003353 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 479431003354 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 479431003355 purine monophosphate binding site [chemical binding]; other site 479431003356 dimer interface [polypeptide binding]; other site 479431003357 putative catalytic residues [active] 479431003358 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 479431003359 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 479431003360 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 479431003361 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 479431003362 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479431003363 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479431003364 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431003365 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431003366 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 479431003367 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 479431003368 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 479431003369 homodimer interface [polypeptide binding]; other site 479431003370 NADP binding site [chemical binding]; other site 479431003371 substrate binding site [chemical binding]; other site 479431003372 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 479431003373 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479431003374 MarR family; Region: MarR_2; cl17246 479431003375 MarR family; Region: MarR_2; cl17246 479431003376 isocitrate dehydrogenase; Validated; Region: PRK08299 479431003377 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431003378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431003379 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431003380 Helix-turn-helix domain; Region: HTH_28; pfam13518 479431003381 Winged helix-turn helix; Region: HTH_29; pfam13551 479431003382 Homeodomain-like domain; Region: HTH_32; pfam13565 479431003383 Integrase core domain; Region: rve; pfam00665 479431003384 Integrase core domain; Region: rve_3; cl15866 479431003385 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 479431003386 AAA domain; Region: AAA_22; pfam13401 479431003387 AAA ATPase domain; Region: AAA_16; pfam13191 479431003388 Walker A motif; other site 479431003389 ATP binding site [chemical binding]; other site 479431003390 Walker B motif; other site 479431003391 arginine finger; other site 479431003392 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431003393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431003394 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431003395 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 479431003396 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 479431003397 dimer interface [polypeptide binding]; other site 479431003398 substrate binding site [chemical binding]; other site 479431003399 ATP binding site [chemical binding]; other site 479431003400 Putative transcription activator [Transcription]; Region: TenA; COG0819 479431003401 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431003402 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 479431003403 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 479431003404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431003405 Walker A/P-loop; other site 479431003406 ATP binding site [chemical binding]; other site 479431003407 Q-loop/lid; other site 479431003408 ABC transporter signature motif; other site 479431003409 Walker B; other site 479431003410 D-loop; other site 479431003411 H-loop/switch region; other site 479431003412 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 479431003413 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 479431003414 active site 479431003415 HIGH motif; other site 479431003416 dimer interface [polypeptide binding]; other site 479431003417 KMSKS motif; other site 479431003418 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 479431003419 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 479431003420 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 479431003421 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479431003422 catalytic residues [active] 479431003423 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479431003424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431003425 DNA-binding site [nucleotide binding]; DNA binding site 479431003426 FCD domain; Region: FCD; pfam07729 479431003427 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 479431003428 Aspartase; Region: Aspartase; cd01357 479431003429 active sites [active] 479431003430 tetramer interface [polypeptide binding]; other site 479431003431 L-asparaginase II; Region: Asparaginase_II; pfam06089 479431003432 L-asparagine permease; Provisional; Region: PRK15049 479431003433 malate dehydrogenase; Provisional; Region: PRK13529 479431003434 Malic enzyme, N-terminal domain; Region: malic; pfam00390 479431003435 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 479431003436 NAD(P) binding pocket [chemical binding]; other site 479431003437 Transcription factor WhiB; Region: Whib; pfam02467 479431003438 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 479431003439 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 479431003440 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 479431003441 Protein kinase domain; Region: Pkinase; pfam00069 479431003442 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431003443 active site 479431003444 ATP binding site [chemical binding]; other site 479431003445 substrate binding site [chemical binding]; other site 479431003446 activation loop (A-loop); other site 479431003447 von Willebrand factor type A domain; Region: VWA_2; pfam13519 479431003448 metal ion-dependent adhesion site (MIDAS); other site 479431003449 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431003450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431003451 non-specific DNA binding site [nucleotide binding]; other site 479431003452 salt bridge; other site 479431003453 sequence-specific DNA binding site [nucleotide binding]; other site 479431003454 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 479431003455 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 479431003456 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 479431003457 L-aspartate oxidase; Provisional; Region: PRK06175 479431003458 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 479431003459 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 479431003460 putative Iron-sulfur protein interface [polypeptide binding]; other site 479431003461 putative proximal heme binding site [chemical binding]; other site 479431003462 putative SdhC-like subunit interface [polypeptide binding]; other site 479431003463 putative distal heme binding site [chemical binding]; other site 479431003464 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 479431003465 putative Iron-sulfur protein interface [polypeptide binding]; other site 479431003466 putative proximal heme binding site [chemical binding]; other site 479431003467 putative SdhD-like interface [polypeptide binding]; other site 479431003468 putative distal heme binding site [chemical binding]; other site 479431003469 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 479431003470 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 479431003471 ligand binding site [chemical binding]; other site 479431003472 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 479431003473 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479431003474 Walker A/P-loop; other site 479431003475 ATP binding site [chemical binding]; other site 479431003476 Q-loop/lid; other site 479431003477 ABC transporter signature motif; other site 479431003478 Walker B; other site 479431003479 D-loop; other site 479431003480 H-loop/switch region; other site 479431003481 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 479431003482 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479431003483 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 479431003484 TM-ABC transporter signature motif; other site 479431003485 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479431003486 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 479431003487 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 479431003488 TM-ABC transporter signature motif; other site 479431003489 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 479431003490 active site 479431003491 catalytic motif [active] 479431003492 Zn binding site [ion binding]; other site 479431003493 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 479431003494 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 479431003495 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 479431003496 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 479431003497 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431003498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431003499 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431003500 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 479431003501 adenosine deaminase; Provisional; Region: PRK09358 479431003502 active site 479431003503 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 479431003504 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 479431003505 active site 479431003506 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 479431003507 phosphopeptide binding site; other site 479431003508 Protein kinase domain; Region: Pkinase; pfam00069 479431003509 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431003510 active site 479431003511 ATP binding site [chemical binding]; other site 479431003512 substrate binding site [chemical binding]; other site 479431003513 activation loop (A-loop); other site 479431003514 potential frameshift: common BLAST hit: gi|220912101|ref|YP_002487410.1| Fibronectin type III domain protein 479431003515 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479431003516 Interdomain contacts; other site 479431003517 Cytokine receptor motif; other site 479431003518 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479431003519 Interdomain contacts; other site 479431003520 Cytokine receptor motif; other site 479431003521 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479431003522 Interdomain contacts; other site 479431003523 MoxR-like ATPases [General function prediction only]; Region: COG0714 479431003524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431003525 Walker A motif; other site 479431003526 ATP binding site [chemical binding]; other site 479431003527 Walker B motif; other site 479431003528 arginine finger; other site 479431003529 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479431003530 Protein of unknown function DUF58; Region: DUF58; pfam01882 479431003531 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 479431003532 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 479431003533 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479431003534 phosphopeptide binding site; other site 479431003535 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 479431003536 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479431003537 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 479431003538 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479431003539 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 479431003540 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 479431003541 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 479431003542 RDD family; Region: RDD; pfam06271 479431003543 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 479431003544 phosphopeptide binding site; other site 479431003545 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 479431003546 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 479431003547 NAD binding site [chemical binding]; other site 479431003548 catalytic Zn binding site [ion binding]; other site 479431003549 substrate binding site [chemical binding]; other site 479431003550 structural Zn binding site [ion binding]; other site 479431003551 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 479431003552 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 479431003553 putative active site [active] 479431003554 Fe(II) binding site [ion binding]; other site 479431003555 putative dimer interface [polypeptide binding]; other site 479431003556 putative tetramer interface [polypeptide binding]; other site 479431003557 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431003558 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431003559 FAD binding domain; Region: FAD_binding_3; pfam01494 479431003560 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 479431003561 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431003562 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479431003563 metabolite-proton symporter; Region: 2A0106; TIGR00883 479431003564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431003565 putative substrate translocation pore; other site 479431003566 ferredoxin-NADP+ reductase; Region: PLN02852 479431003567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431003568 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479431003569 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479431003570 NAD(P) binding site [chemical binding]; other site 479431003571 catalytic residues [active] 479431003572 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 479431003573 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479431003574 NAD(P) binding site [chemical binding]; other site 479431003575 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 479431003576 intersubunit interface [polypeptide binding]; other site 479431003577 active site 479431003578 catalytic residue [active] 479431003579 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479431003580 active site 479431003581 META domain; Region: META; pfam03724 479431003582 META domain; Region: META; pfam03724 479431003583 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 479431003584 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 479431003585 active site 479431003586 substrate binding site [chemical binding]; other site 479431003587 metal binding site [ion binding]; metal-binding site 479431003588 purine nucleoside phosphorylase; Provisional; Region: PRK08202 479431003589 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479431003590 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431003591 active site 479431003592 ATP binding site [chemical binding]; other site 479431003593 substrate binding site [chemical binding]; other site 479431003594 activation loop (A-loop); other site 479431003595 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479431003596 membrane ATPase/protein kinase; Provisional; Region: PRK09435 479431003597 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 479431003598 Walker A; other site 479431003599 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479431003600 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 479431003601 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 479431003602 metal binding site [ion binding]; metal-binding site 479431003603 putative dimer interface [polypeptide binding]; other site 479431003604 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 479431003605 putative active site pocket [active] 479431003606 dimerization interface [polypeptide binding]; other site 479431003607 putative catalytic residue [active] 479431003608 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 479431003609 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431003610 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431003611 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479431003612 short chain dehydrogenase; Validated; Region: PRK08264 479431003613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431003614 NAD(P) binding site [chemical binding]; other site 479431003615 active site 479431003616 Predicted transcriptional regulators [Transcription]; Region: COG1733 479431003617 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479431003618 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 479431003619 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 479431003620 30S subunit binding site; other site 479431003621 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 479431003622 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 479431003623 SEC-C motif; Region: SEC-C; pfam02810 479431003624 Short C-terminal domain; Region: SHOCT; pfam09851 479431003625 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 479431003626 Helix-turn-helix domain; Region: HTH_17; pfam12728 479431003627 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 479431003628 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 479431003629 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479431003630 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 479431003631 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 479431003632 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 479431003633 Predicted membrane protein [Function unknown]; Region: COG4325 479431003634 Uncharacterized conserved protein [Function unknown]; Region: COG2353 479431003635 Predicted GTPases [General function prediction only]; Region: COG1162 479431003636 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 479431003637 GTPase/Zn-binding domain interface [polypeptide binding]; other site 479431003638 GTP/Mg2+ binding site [chemical binding]; other site 479431003639 G4 box; other site 479431003640 G5 box; other site 479431003641 G1 box; other site 479431003642 Switch I region; other site 479431003643 G2 box; other site 479431003644 G3 box; other site 479431003645 Switch II region; other site 479431003646 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 479431003647 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 479431003648 hinge; other site 479431003649 active site 479431003650 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479431003651 Transposase domain (DUF772); Region: DUF772; pfam05598 479431003652 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431003653 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431003654 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 479431003655 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479431003656 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 479431003657 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 479431003658 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479431003659 catalytic loop [active] 479431003660 iron binding site [ion binding]; other site 479431003661 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 479431003662 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 479431003663 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 479431003664 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 479431003665 RibD C-terminal domain; Region: RibD_C; cl17279 479431003666 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 479431003667 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431003668 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479431003669 active site 479431003670 ATP binding site [chemical binding]; other site 479431003671 substrate binding site [chemical binding]; other site 479431003672 activation loop (A-loop); other site 479431003673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431003674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431003675 active site 479431003676 ATP binding site [chemical binding]; other site 479431003677 substrate binding site [chemical binding]; other site 479431003678 activation loop (A-loop); other site 479431003679 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 479431003680 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 479431003681 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479431003682 phosphopeptide binding site; other site 479431003683 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 479431003684 putative deacylase active site [active] 479431003685 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 479431003686 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 479431003687 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431003688 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 479431003689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431003690 ABC-ATPase subunit interface; other site 479431003691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 479431003692 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 479431003693 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 479431003694 Walker A/P-loop; other site 479431003695 ATP binding site [chemical binding]; other site 479431003696 Q-loop/lid; other site 479431003697 ABC transporter signature motif; other site 479431003698 Walker B; other site 479431003699 D-loop; other site 479431003700 H-loop/switch region; other site 479431003701 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479431003702 Cytochrome P450; Region: p450; cl12078 479431003703 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 479431003704 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431003705 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431003706 DNA binding residues [nucleotide binding] 479431003707 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 479431003708 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 479431003709 carboxyltransferase (CT) interaction site; other site 479431003710 biotinylation site [posttranslational modification]; other site 479431003711 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 479431003712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479431003713 putative active site [active] 479431003714 heme pocket [chemical binding]; other site 479431003715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 479431003716 Histidine kinase; Region: HisKA_2; pfam07568 479431003717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431003718 ATP binding site [chemical binding]; other site 479431003719 Mg2+ binding site [ion binding]; other site 479431003720 G-X-G motif; other site 479431003721 Transcription factor WhiB; Region: Whib; pfam02467 479431003722 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 479431003723 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 479431003724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431003725 Coenzyme A binding pocket [chemical binding]; other site 479431003726 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431003727 catalytic core [active] 479431003728 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 479431003729 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 479431003730 aromatic arch; other site 479431003731 DCoH dimer interaction site [polypeptide binding]; other site 479431003732 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 479431003733 DCoH tetramer interaction site [polypeptide binding]; other site 479431003734 substrate binding site [chemical binding]; other site 479431003735 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 479431003736 Malic enzyme, N-terminal domain; Region: malic; pfam00390 479431003737 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 479431003738 NAD(P) binding pocket [chemical binding]; other site 479431003739 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431003740 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 479431003741 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431003742 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 479431003743 active sites [active] 479431003744 tetramer interface [polypeptide binding]; other site 479431003745 allantoate amidohydrolase; Reviewed; Region: PRK09290 479431003746 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 479431003747 active site 479431003748 metal binding site [ion binding]; metal-binding site 479431003749 dimer interface [polypeptide binding]; other site 479431003750 imidazolonepropionase; Provisional; Region: PRK14085 479431003751 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431003752 active site 479431003753 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479431003754 D-xylulose kinase; Region: XylB; TIGR01312 479431003755 nucleotide binding site [chemical binding]; other site 479431003756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431003757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431003758 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 479431003759 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479431003760 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 479431003761 TPP-binding site [chemical binding]; other site 479431003762 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 479431003763 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 479431003764 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479431003765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431003766 Walker A/P-loop; other site 479431003767 ATP binding site [chemical binding]; other site 479431003768 Q-loop/lid; other site 479431003769 ABC transporter signature motif; other site 479431003770 Walker B; other site 479431003771 D-loop; other site 479431003772 H-loop/switch region; other site 479431003773 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479431003774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479431003775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431003776 Walker A/P-loop; other site 479431003777 ATP binding site [chemical binding]; other site 479431003778 Q-loop/lid; other site 479431003779 ABC transporter signature motif; other site 479431003780 Walker B; other site 479431003781 D-loop; other site 479431003782 H-loop/switch region; other site 479431003783 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 479431003784 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 479431003785 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 479431003786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431003787 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479431003788 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 479431003789 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 479431003790 nucleoside/Zn binding site; other site 479431003791 dimer interface [polypeptide binding]; other site 479431003792 catalytic motif [active] 479431003793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431003794 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431003795 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 479431003796 active site 479431003797 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 479431003798 Ligand binding site [chemical binding]; other site 479431003799 Electron transfer flavoprotein domain; Region: ETF; pfam01012 479431003800 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 479431003801 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 479431003802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 479431003803 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479431003804 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479431003805 putative acyl-acceptor binding pocket; other site 479431003806 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 479431003807 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 479431003808 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 479431003809 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431003810 catalytic residue [active] 479431003811 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 479431003812 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 479431003813 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 479431003814 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431003815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431003816 non-specific DNA binding site [nucleotide binding]; other site 479431003817 salt bridge; other site 479431003818 sequence-specific DNA binding site [nucleotide binding]; other site 479431003819 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479431003820 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 479431003821 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 479431003822 nucleotide binding pocket [chemical binding]; other site 479431003823 K-X-D-G motif; other site 479431003824 catalytic site [active] 479431003825 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 479431003826 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 479431003827 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479431003828 Cytochrome P450; Region: p450; cl12078 479431003829 Predicted ATPase [General function prediction only]; Region: COG3910 479431003830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 479431003831 Walker A/P-loop; other site 479431003832 ATP binding site [chemical binding]; other site 479431003833 Q-loop/lid; other site 479431003834 ABC transporter signature motif; other site 479431003835 Walker B; other site 479431003836 D-loop; other site 479431003837 H-loop/switch region; other site 479431003838 TIGR03086 family protein; Region: TIGR03086 479431003839 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479431003840 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431003841 MULE transposase domain; Region: MULE; pfam10551 479431003842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431003843 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431003844 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431003845 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479431003846 active site 479431003847 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 479431003848 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 479431003849 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 479431003850 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 479431003851 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 479431003852 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 479431003853 GatB domain; Region: GatB_Yqey; smart00845 479431003854 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 479431003855 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 479431003856 Predicted membrane protein [Function unknown]; Region: COG3428 479431003857 Bacterial PH domain; Region: DUF304; pfam03703 479431003858 Uncharacterized conserved protein [Function unknown]; Region: COG3402 479431003859 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 479431003860 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479431003861 PYR/PP interface [polypeptide binding]; other site 479431003862 dimer interface [polypeptide binding]; other site 479431003863 TPP binding site [chemical binding]; other site 479431003864 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479431003865 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 479431003866 TPP-binding site [chemical binding]; other site 479431003867 dimer interface [polypeptide binding]; other site 479431003868 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 479431003869 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 479431003870 putative valine binding site [chemical binding]; other site 479431003871 dimer interface [polypeptide binding]; other site 479431003872 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 479431003873 ketol-acid reductoisomerase; Provisional; Region: PRK05479 479431003874 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 479431003875 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 479431003876 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 479431003877 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 479431003878 ligand binding site [chemical binding]; other site 479431003879 NAD binding site [chemical binding]; other site 479431003880 dimerization interface [polypeptide binding]; other site 479431003881 catalytic site [active] 479431003882 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 479431003883 putative L-serine binding site [chemical binding]; other site 479431003884 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 479431003885 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 479431003886 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 479431003887 active site 479431003888 catalytic residues [active] 479431003889 metal binding site [ion binding]; metal-binding site 479431003890 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 479431003891 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 479431003892 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 479431003893 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 479431003894 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 479431003895 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 479431003896 HIGH motif; other site 479431003897 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 479431003898 active site 479431003899 KMSKS motif; other site 479431003900 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 479431003901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431003902 motif II; other site 479431003903 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431003904 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479431003905 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431003906 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 479431003907 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 479431003908 substrate binding site [chemical binding]; other site 479431003909 ligand binding site [chemical binding]; other site 479431003910 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 479431003911 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 479431003912 substrate binding site [chemical binding]; other site 479431003913 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 479431003914 IHF - DNA interface [nucleotide binding]; other site 479431003915 IHF dimer interface [polypeptide binding]; other site 479431003916 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 479431003917 active site 479431003918 Ap6A binding site [chemical binding]; other site 479431003919 nudix motif; other site 479431003920 metal binding site [ion binding]; metal-binding site 479431003921 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431003922 catalytic core [active] 479431003923 polyphosphate kinase; Provisional; Region: PRK05443 479431003924 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 479431003925 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 479431003926 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 479431003927 putative domain interface [polypeptide binding]; other site 479431003928 putative active site [active] 479431003929 catalytic site [active] 479431003930 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 479431003931 putative domain interface [polypeptide binding]; other site 479431003932 putative active site [active] 479431003933 catalytic site [active] 479431003934 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479431003935 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479431003936 putative acyl-acceptor binding pocket; other site 479431003937 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 479431003938 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 479431003939 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 479431003940 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 479431003941 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 479431003942 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 479431003943 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 479431003944 AsnC family; Region: AsnC_trans_reg; pfam01037 479431003945 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479431003946 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 479431003947 ATP binding site [chemical binding]; other site 479431003948 dimerization interface [polypeptide binding]; other site 479431003949 thiamine monophosphate kinase; Provisional; Region: PRK05731 479431003950 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 479431003951 ligand binding site [chemical binding]; other site 479431003952 active site 479431003953 UGI interface [polypeptide binding]; other site 479431003954 catalytic site [active] 479431003955 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 479431003956 Cl- selectivity filter; other site 479431003957 Cl- binding residues [ion binding]; other site 479431003958 pore gating glutamate residue; other site 479431003959 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 479431003960 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 479431003961 active site pocket [active] 479431003962 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 479431003963 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431003964 active site 479431003965 HIGH motif; other site 479431003966 nucleotide binding site [chemical binding]; other site 479431003967 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 479431003968 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 479431003969 active site 479431003970 KMSKS motif; other site 479431003971 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 479431003972 tRNA binding surface [nucleotide binding]; other site 479431003973 anticodon binding site; other site 479431003974 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 479431003975 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 479431003976 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479431003977 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479431003978 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 479431003979 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 479431003980 active site 479431003981 multimer interface [polypeptide binding]; other site 479431003982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431003983 Coenzyme A binding pocket [chemical binding]; other site 479431003984 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 479431003985 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 479431003986 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 479431003987 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 479431003988 homodimer interface [polypeptide binding]; other site 479431003989 oligonucleotide binding site [chemical binding]; other site 479431003990 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 479431003991 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 479431003992 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 479431003993 GTPase CgtA; Reviewed; Region: obgE; PRK12296 479431003994 GTP1/OBG; Region: GTP1_OBG; pfam01018 479431003995 Obg GTPase; Region: Obg; cd01898 479431003996 G1 box; other site 479431003997 GTP/Mg2+ binding site [chemical binding]; other site 479431003998 Switch I region; other site 479431003999 G2 box; other site 479431004000 G3 box; other site 479431004001 Switch II region; other site 479431004002 G4 box; other site 479431004003 G5 box; other site 479431004004 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 479431004005 gamma-glutamyl kinase; Provisional; Region: PRK05429 479431004006 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 479431004007 nucleotide binding site [chemical binding]; other site 479431004008 homotetrameric interface [polypeptide binding]; other site 479431004009 putative phosphate binding site [ion binding]; other site 479431004010 putative allosteric binding site; other site 479431004011 PUA domain; Region: PUA; pfam01472 479431004012 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 479431004013 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 479431004014 putative catalytic cysteine [active] 479431004015 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 479431004016 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 479431004017 active site 479431004018 (T/H)XGH motif; other site 479431004019 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 479431004020 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431004021 catalytic core [active] 479431004022 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431004023 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 479431004024 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 479431004025 Cutinase; Region: Cutinase; pfam01083 479431004026 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479431004027 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 479431004028 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 479431004029 Competence protein; Region: Competence; pfam03772 479431004030 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479431004031 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 479431004032 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431004033 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 479431004034 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 479431004035 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 479431004036 putative active site [active] 479431004037 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431004038 active site 479431004039 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 479431004040 NAD binding site [chemical binding]; other site 479431004041 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431004042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431004043 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431004044 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 479431004045 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 479431004046 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 479431004047 active site 479431004048 intersubunit interface [polypeptide binding]; other site 479431004049 catalytic residue [active] 479431004050 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 479431004051 classical (c) SDRs; Region: SDR_c; cd05233 479431004052 NAD(P) binding site [chemical binding]; other site 479431004053 active site 479431004054 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431004055 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 479431004056 putative NAD(P) binding site [chemical binding]; other site 479431004057 catalytic Zn binding site [ion binding]; other site 479431004058 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 479431004059 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431004060 putative NAD(P) binding site [chemical binding]; other site 479431004061 catalytic Zn binding site [ion binding]; other site 479431004062 glycerol kinase; Provisional; Region: glpK; PRK00047 479431004063 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 479431004064 N- and C-terminal domain interface [polypeptide binding]; other site 479431004065 active site 479431004066 MgATP binding site [chemical binding]; other site 479431004067 catalytic site [active] 479431004068 metal binding site [ion binding]; metal-binding site 479431004069 glycerol binding site [chemical binding]; other site 479431004070 homotetramer interface [polypeptide binding]; other site 479431004071 homodimer interface [polypeptide binding]; other site 479431004072 FBP binding site [chemical binding]; other site 479431004073 protein IIAGlc interface [polypeptide binding]; other site 479431004074 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 479431004075 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 479431004076 ligand binding site [chemical binding]; other site 479431004077 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479431004078 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479431004079 Walker A/P-loop; other site 479431004080 ATP binding site [chemical binding]; other site 479431004081 Q-loop/lid; other site 479431004082 ABC transporter signature motif; other site 479431004083 Walker B; other site 479431004084 D-loop; other site 479431004085 H-loop/switch region; other site 479431004086 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 479431004087 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479431004088 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 479431004089 Metal-binding active site; metal-binding site 479431004090 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479431004091 classical (c) SDRs; Region: SDR_c; cd05233 479431004092 NAD(P) binding site [chemical binding]; other site 479431004093 active site 479431004094 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 479431004095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 479431004096 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 479431004097 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479431004098 inhibitor-cofactor binding pocket; inhibition site 479431004099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431004100 catalytic residue [active] 479431004101 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 479431004102 dimer interface [polypeptide binding]; other site 479431004103 active site 479431004104 Schiff base residues; other site 479431004105 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 479431004106 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 479431004107 active site 479431004108 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 479431004109 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 479431004110 domain interfaces; other site 479431004111 active site 479431004112 ferrochelatase; Reviewed; Region: hemH; PRK00035 479431004113 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 479431004114 C-terminal domain interface [polypeptide binding]; other site 479431004115 active site 479431004116 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 479431004117 active site 479431004118 N-terminal domain interface [polypeptide binding]; other site 479431004119 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 479431004120 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 479431004121 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 479431004122 substrate binding site [chemical binding]; other site 479431004123 active site 479431004124 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 479431004125 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 479431004126 NAD(P) binding pocket [chemical binding]; other site 479431004127 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 479431004128 threonine synthase; Validated; Region: PRK07591 479431004129 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 479431004130 homodimer interface [polypeptide binding]; other site 479431004131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431004132 catalytic residue [active] 479431004133 hypothetical protein; Reviewed; Region: PRK07914 479431004134 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 479431004135 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 479431004136 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 479431004137 RibD C-terminal domain; Region: RibD_C; cl17279 479431004138 YCII-related domain; Region: YCII; cl00999 479431004139 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479431004140 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431004141 GTP-binding protein LepA; Provisional; Region: PRK05433 479431004142 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 479431004143 G1 box; other site 479431004144 putative GEF interaction site [polypeptide binding]; other site 479431004145 GTP/Mg2+ binding site [chemical binding]; other site 479431004146 Switch I region; other site 479431004147 G2 box; other site 479431004148 G3 box; other site 479431004149 Switch II region; other site 479431004150 G4 box; other site 479431004151 G5 box; other site 479431004152 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 479431004153 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 479431004154 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 479431004155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431004156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431004157 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479431004158 NAD(P) binding site [chemical binding]; other site 479431004159 active site 479431004160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431004161 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479431004162 NAD(P) binding site [chemical binding]; other site 479431004163 active site 479431004164 hypothetical protein; Provisional; Region: PRK06753 479431004165 hypothetical protein; Provisional; Region: PRK07236 479431004166 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 479431004167 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431004168 Putative sensor; Region: Sensor; pfam13796 479431004169 H+ Antiporter protein; Region: 2A0121; TIGR00900 479431004170 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479431004171 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431004172 NAD(P) binding site [chemical binding]; other site 479431004173 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 479431004174 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 479431004175 generic binding surface I; other site 479431004176 generic binding surface II; other site 479431004177 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 479431004178 putative active site [active] 479431004179 putative catalytic site [active] 479431004180 putative Mg binding site IVb [ion binding]; other site 479431004181 putative phosphate binding site [ion binding]; other site 479431004182 putative DNA binding site [nucleotide binding]; other site 479431004183 putative Mg binding site IVa [ion binding]; other site 479431004184 coproporphyrinogen III oxidase; Validated; Region: PRK05628 479431004185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431004186 FeS/SAM binding site; other site 479431004187 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 479431004188 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 479431004189 HTH domain; Region: HTH_11; cl17392 479431004190 chaperone protein DnaJ; Provisional; Region: PRK14278 479431004191 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 479431004192 HSP70 interaction site [polypeptide binding]; other site 479431004193 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 479431004194 Zn binding sites [ion binding]; other site 479431004195 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 479431004196 dimer interface [polypeptide binding]; other site 479431004197 RNA methyltransferase, RsmE family; Region: TIGR00046 479431004198 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 479431004199 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431004200 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479431004201 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 479431004202 nucleotide binding site/active site [active] 479431004203 HIT family signature motif; other site 479431004204 catalytic residue [active] 479431004205 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 479431004206 PhoH-like protein; Region: PhoH; pfam02562 479431004207 metal-binding heat shock protein; Provisional; Region: PRK00016 479431004208 Domain of unknown function DUF21; Region: DUF21; pfam01595 479431004209 FOG: CBS domain [General function prediction only]; Region: COG0517 479431004210 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479431004211 GTPase Era; Reviewed; Region: era; PRK00089 479431004212 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 479431004213 Switch I region; other site 479431004214 GTP/Mg2+ binding site [chemical binding]; other site 479431004215 G2 box; other site 479431004216 Switch II region; other site 479431004217 G3 box; other site 479431004218 G4 box; other site 479431004219 G5 box; other site 479431004220 KH domain; Region: KH_2; pfam07650 479431004221 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 479431004222 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 479431004223 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479431004224 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 479431004225 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 479431004226 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479431004227 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 479431004228 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 479431004229 putative NADH binding site [chemical binding]; other site 479431004230 putative active site [active] 479431004231 nudix motif; other site 479431004232 putative metal binding site [ion binding]; other site 479431004233 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 479431004234 Part of AAA domain; Region: AAA_19; pfam13245 479431004235 Family description; Region: UvrD_C_2; pfam13538 479431004236 HRDC domain; Region: HRDC; pfam00570 479431004237 Transcription factor WhiB; Region: Whib; pfam02467 479431004238 FOG: CBS domain [General function prediction only]; Region: COG0517 479431004239 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 479431004240 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 479431004241 metal binding triad; other site 479431004242 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 479431004243 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 479431004244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479431004245 substrate binding pocket [chemical binding]; other site 479431004246 membrane-bound complex binding site; other site 479431004247 hinge residues; other site 479431004248 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 479431004249 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 479431004250 ABC1 family; Region: ABC1; pfam03109 479431004251 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479431004252 active site 479431004253 ATP binding site [chemical binding]; other site 479431004254 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479431004255 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479431004256 active site 479431004257 catalytic tetrad [active] 479431004258 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 479431004259 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 479431004260 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 479431004261 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 479431004262 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 479431004263 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 479431004264 hypothetical protein; Validated; Region: PRK00068 479431004265 Homeodomain-like domain; Region: HTH_32; pfam13565 479431004266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 479431004267 Integrase core domain; Region: rve; pfam00665 479431004268 Integrase core domain; Region: rve_3; pfam13683 479431004269 RibD C-terminal domain; Region: RibD_C; cl17279 479431004270 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479431004271 DDE superfamily endonuclease; Region: DDE_5; pfam13546 479431004272 Transposase domain (DUF772); Region: DUF772; pfam05598 479431004273 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431004274 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431004275 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 479431004276 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479431004277 hydrophobic ligand binding site; other site 479431004278 RibD C-terminal domain; Region: RibD_C; cl17279 479431004279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431004280 dimerization interface [polypeptide binding]; other site 479431004281 putative DNA binding site [nucleotide binding]; other site 479431004282 putative Zn2+ binding site [ion binding]; other site 479431004283 RibD C-terminal domain; Region: RibD_C; cl17279 479431004284 Chlorophyllase enzyme; Region: Chlorophyllase2; pfam12740 479431004285 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 479431004286 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 479431004287 SLBB domain; Region: SLBB; pfam10531 479431004288 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 479431004289 ApbE family; Region: ApbE; pfam02424 479431004290 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 479431004291 Short C-terminal domain; Region: SHOCT; pfam09851 479431004292 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 479431004293 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 479431004294 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 479431004295 tetramer interface [polypeptide binding]; other site 479431004296 heme binding pocket [chemical binding]; other site 479431004297 NADPH binding site [chemical binding]; other site 479431004298 Amino acid permease; Region: AA_permease; pfam00324 479431004299 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 479431004300 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 479431004301 active site 479431004302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431004303 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479431004304 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479431004305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431004306 S-adenosylmethionine binding site [chemical binding]; other site 479431004307 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431004308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431004309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431004310 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431004311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431004312 S-adenosylmethionine binding site [chemical binding]; other site 479431004313 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479431004314 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431004315 Hemerythrin-like domain; Region: Hr-like; cd12108 479431004316 Fe binding site [ion binding]; other site 479431004317 peptide chain release factor 2; Validated; Region: prfB; PRK00578 479431004318 This domain is found in peptide chain release factors; Region: PCRF; smart00937 479431004319 RF-1 domain; Region: RF-1; pfam00472 479431004320 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431004321 Ligand Binding Site [chemical binding]; other site 479431004322 diacylglycerol kinase; Reviewed; Region: PRK11914 479431004323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431004324 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479431004325 Walker A motif; other site 479431004326 ATP binding site [chemical binding]; other site 479431004327 Walker B motif; other site 479431004328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431004329 Helix-turn-helix domain; Region: HTH_38; pfam13936 479431004330 Integrase core domain; Region: rve; pfam00665 479431004331 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 479431004332 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 479431004333 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 479431004334 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 479431004335 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 479431004336 active site 479431004337 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479431004338 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431004339 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 479431004340 DNA polymerase IV; Validated; Region: PRK03858 479431004341 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 479431004342 active site 479431004343 DNA binding site [nucleotide binding] 479431004344 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 479431004345 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431004346 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479431004347 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 479431004348 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 479431004349 Amidinotransferase; Region: Amidinotransf; cl12043 479431004350 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 479431004351 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 479431004352 DAK2 domain; Region: Dak2; cl03685 479431004353 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 479431004354 active pocket/dimerization site; other site 479431004355 active site 479431004356 phosphorylation site [posttranslational modification] 479431004357 Penicillinase repressor; Region: Pencillinase_R; cl17580 479431004358 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 479431004359 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479431004360 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 479431004361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431004362 dimer interface [polypeptide binding]; other site 479431004363 conserved gate region; other site 479431004364 putative PBP binding loops; other site 479431004365 ABC-ATPase subunit interface; other site 479431004366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431004367 dimer interface [polypeptide binding]; other site 479431004368 conserved gate region; other site 479431004369 putative PBP binding loops; other site 479431004370 ABC-ATPase subunit interface; other site 479431004371 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 479431004372 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 479431004373 Walker A/P-loop; other site 479431004374 ATP binding site [chemical binding]; other site 479431004375 Q-loop/lid; other site 479431004376 ABC transporter signature motif; other site 479431004377 Walker B; other site 479431004378 D-loop; other site 479431004379 H-loop/switch region; other site 479431004380 TOBE domain; Region: TOBE_2; pfam08402 479431004381 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 479431004382 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 479431004383 Walker A/P-loop; other site 479431004384 ATP binding site [chemical binding]; other site 479431004385 Q-loop/lid; other site 479431004386 ABC transporter signature motif; other site 479431004387 Walker B; other site 479431004388 D-loop; other site 479431004389 H-loop/switch region; other site 479431004390 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 479431004391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431004392 putative PBP binding loops; other site 479431004393 dimer interface [polypeptide binding]; other site 479431004394 ABC-ATPase subunit interface; other site 479431004395 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 479431004396 NMT1/THI5 like; Region: NMT1; pfam09084 479431004397 serine O-acetyltransferase; Region: cysE; TIGR01172 479431004398 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 479431004399 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 479431004400 trimer interface [polypeptide binding]; other site 479431004401 active site 479431004402 substrate binding site [chemical binding]; other site 479431004403 CoA binding site [chemical binding]; other site 479431004404 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 479431004405 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 479431004406 dimer interface [polypeptide binding]; other site 479431004407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431004408 catalytic residue [active] 479431004409 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 479431004410 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 479431004411 ATP binding site [chemical binding]; other site 479431004412 Walker A motif; other site 479431004413 hexamer interface [polypeptide binding]; other site 479431004414 Walker B motif; other site 479431004415 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431004416 TAP-like protein; Region: Abhydrolase_4; pfam08386 479431004417 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479431004418 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 479431004419 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 479431004420 active site 479431004421 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 479431004422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431004423 Walker A/P-loop; other site 479431004424 ATP binding site [chemical binding]; other site 479431004425 Q-loop/lid; other site 479431004426 ABC transporter signature motif; other site 479431004427 Walker B; other site 479431004428 D-loop; other site 479431004429 H-loop/switch region; other site 479431004430 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 479431004431 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 479431004432 SmpB-tmRNA interface; other site 479431004433 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 479431004434 PRC-barrel domain; Region: PRC; pfam05239 479431004435 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 479431004436 MgtE intracellular N domain; Region: MgtE_N; smart00924 479431004437 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 479431004438 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 479431004439 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 479431004440 Methylamine utilisation protein MauE; Region: MauE; pfam07291 479431004441 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 479431004442 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 479431004443 catalytic residues [active] 479431004444 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 479431004445 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 479431004446 D-pathway; other site 479431004447 Putative ubiquinol binding site [chemical binding]; other site 479431004448 Low-spin heme (heme b) binding site [chemical binding]; other site 479431004449 Putative water exit pathway; other site 479431004450 Binuclear center (heme o3/CuB) [ion binding]; other site 479431004451 K-pathway; other site 479431004452 Putative proton exit pathway; other site 479431004453 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479431004454 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479431004455 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 479431004456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431004457 motif II; other site 479431004458 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 479431004459 dimer interface [polypeptide binding]; other site 479431004460 putative active site [active] 479431004461 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 479431004462 active site 479431004463 catalytic site [active] 479431004464 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431004465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431004466 DNA binding site [nucleotide binding] 479431004467 domain linker motif; other site 479431004468 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431004469 ligand binding site [chemical binding]; other site 479431004470 dimerization interface [polypeptide binding]; other site 479431004471 Isochorismatase family; Region: Isochorismatase; pfam00857 479431004472 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 479431004473 catalytic triad [active] 479431004474 conserved cis-peptide bond; other site 479431004475 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 479431004476 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 479431004477 active site 479431004478 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 479431004479 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 479431004480 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 479431004481 MPN+ (JAMM) motif; other site 479431004482 Zinc-binding site [ion binding]; other site 479431004483 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 479431004484 MoaE interaction surface [polypeptide binding]; other site 479431004485 MoeB interaction surface [polypeptide binding]; other site 479431004486 thiocarboxylated glycine; other site 479431004487 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 479431004488 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 479431004489 dimer interface [polypeptide binding]; other site 479431004490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431004491 catalytic residue [active] 479431004492 glutamate racemase; Provisional; Region: PRK00865 479431004493 ribonuclease PH; Reviewed; Region: rph; PRK00173 479431004494 Ribonuclease PH; Region: RNase_PH_bact; cd11362 479431004495 hexamer interface [polypeptide binding]; other site 479431004496 active site 479431004497 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 479431004498 active site 479431004499 dimerization interface [polypeptide binding]; other site 479431004500 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 479431004501 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 479431004502 catalytic triad [active] 479431004503 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 479431004504 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 479431004505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 479431004506 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479431004507 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 479431004508 N-ethylammeline chlorohydrolase; Provisional; Region: PRK08393 479431004509 active site 479431004510 putative substrate binding pocket [chemical binding]; other site 479431004511 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 479431004512 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 479431004513 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 479431004514 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 479431004515 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 479431004516 putative active site [active] 479431004517 putative catalytic site [active] 479431004518 phosphoenolpyruvate synthase; Validated; Region: PRK06241 479431004519 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 479431004520 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 479431004521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431004522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431004523 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 479431004524 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 479431004525 active site 479431004526 FMN binding site [chemical binding]; other site 479431004527 substrate binding site [chemical binding]; other site 479431004528 homotetramer interface [polypeptide binding]; other site 479431004529 catalytic residue [active] 479431004530 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 479431004531 hypothetical protein; Reviewed; Region: PRK09588 479431004532 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479431004533 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 479431004534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431004535 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431004536 sequence-specific DNA binding site [nucleotide binding]; other site 479431004537 salt bridge; other site 479431004538 Cupin domain; Region: Cupin_2; pfam07883 479431004539 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479431004540 Zn2+ binding site [ion binding]; other site 479431004541 Mg2+ binding site [ion binding]; other site 479431004542 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 479431004543 active site 479431004544 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 479431004545 Predicted membrane protein [Function unknown]; Region: COG2860 479431004546 UPF0126 domain; Region: UPF0126; pfam03458 479431004547 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 479431004548 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479431004549 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 479431004550 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431004551 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 479431004552 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 479431004553 carboxyltransferase (CT) interaction site; other site 479431004554 biotinylation site [posttranslational modification]; other site 479431004555 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 479431004556 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 479431004557 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 479431004558 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479431004559 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431004560 active site 479431004561 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431004562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431004563 Predicted acyl esterases [General function prediction only]; Region: COG2936 479431004564 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 479431004565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431004566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431004567 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 479431004568 putative homodimer interface [polypeptide binding]; other site 479431004569 putative homotetramer interface [polypeptide binding]; other site 479431004570 putative allosteric switch controlling residues; other site 479431004571 putative metal binding site [ion binding]; other site 479431004572 putative homodimer-homodimer interface [polypeptide binding]; other site 479431004573 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 479431004574 metal-binding site [ion binding] 479431004575 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 479431004576 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 479431004577 metal-binding site [ion binding] 479431004578 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479431004579 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 479431004580 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 479431004581 metal-binding site [ion binding] 479431004582 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479431004583 Soluble P-type ATPase [General function prediction only]; Region: COG4087 479431004584 Histidine kinase; Region: HisKA_3; pfam07730 479431004585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431004586 ATP binding site [chemical binding]; other site 479431004587 Mg2+ binding site [ion binding]; other site 479431004588 G-X-G motif; other site 479431004589 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431004590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431004591 active site 479431004592 phosphorylation site [posttranslational modification] 479431004593 intermolecular recognition site; other site 479431004594 dimerization interface [polypeptide binding]; other site 479431004595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431004596 DNA binding residues [nucleotide binding] 479431004597 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431004598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431004599 active site 479431004600 phosphorylation site [posttranslational modification] 479431004601 intermolecular recognition site; other site 479431004602 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479431004603 putative sugar binding sites [chemical binding]; other site 479431004604 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 479431004605 Q-X-W motif; other site 479431004606 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 479431004607 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479431004608 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 479431004609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431004610 motif II; other site 479431004611 Short C-terminal domain; Region: SHOCT; pfam09851 479431004612 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479431004613 GAF domain; Region: GAF; pfam01590 479431004614 GAF domain; Region: GAF_2; pfam13185 479431004615 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479431004616 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431004617 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431004618 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 479431004619 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431004620 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431004621 Walker A/P-loop; other site 479431004622 ATP binding site [chemical binding]; other site 479431004623 Q-loop/lid; other site 479431004624 ABC transporter signature motif; other site 479431004625 Walker B; other site 479431004626 D-loop; other site 479431004627 H-loop/switch region; other site 479431004628 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 479431004629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431004630 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 479431004631 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 479431004632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 479431004633 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479431004634 Clp amino terminal domain; Region: Clp_N; pfam02861 479431004635 Homeodomain-like domain; Region: HTH_23; cl17451 479431004636 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 479431004637 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 479431004638 ligand binding site [chemical binding]; other site 479431004639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431004640 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431004641 pyruvate kinase; Provisional; Region: PRK06247 479431004642 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 479431004643 domain interfaces; other site 479431004644 active site 479431004645 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479431004646 active site 479431004647 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 479431004648 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 479431004649 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 479431004650 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 479431004651 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 479431004652 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 479431004653 NAD binding site [chemical binding]; other site 479431004654 homodimer interface [polypeptide binding]; other site 479431004655 active site 479431004656 substrate binding site [chemical binding]; other site 479431004657 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 479431004658 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 479431004659 putative active site [active] 479431004660 putative catalytic site [active] 479431004661 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 479431004662 Melibiase; Region: Melibiase; pfam02065 479431004663 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479431004664 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479431004665 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479431004666 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479431004667 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 479431004668 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479431004669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431004670 dimer interface [polypeptide binding]; other site 479431004671 conserved gate region; other site 479431004672 putative PBP binding loops; other site 479431004673 ABC-ATPase subunit interface; other site 479431004674 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 479431004675 dimer interface [polypeptide binding]; other site 479431004676 conserved gate region; other site 479431004677 ABC-ATPase subunit interface; other site 479431004678 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 479431004679 Melibiase; Region: Melibiase; pfam02065 479431004680 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 479431004681 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 479431004682 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479431004683 NAD(P) binding site [chemical binding]; other site 479431004684 catalytic residues [active] 479431004685 Protein of unknown function (DUF779); Region: DUF779; pfam05610 479431004686 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 479431004687 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 479431004688 active site 479431004689 HIGH motif; other site 479431004690 dimer interface [polypeptide binding]; other site 479431004691 KMSKS motif; other site 479431004692 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 479431004693 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 479431004694 catalytic site [active] 479431004695 putative active site [active] 479431004696 putative substrate binding site [chemical binding]; other site 479431004697 dimer interface [polypeptide binding]; other site 479431004698 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 479431004699 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 479431004700 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479431004701 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 479431004702 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 479431004703 FAD binding pocket [chemical binding]; other site 479431004704 FAD binding motif [chemical binding]; other site 479431004705 phosphate binding motif [ion binding]; other site 479431004706 NAD binding pocket [chemical binding]; other site 479431004707 Predicted transcriptional regulator [Transcription]; Region: COG2378 479431004708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431004709 dimerization interface [polypeptide binding]; other site 479431004710 putative Zn2+ binding site [ion binding]; other site 479431004711 putative DNA binding site [nucleotide binding]; other site 479431004712 WYL domain; Region: WYL; pfam13280 479431004713 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431004714 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431004715 active site 479431004716 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 479431004717 active site 479431004718 putative catalytic site [active] 479431004719 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 479431004720 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 479431004721 putative dimer interface [polypeptide binding]; other site 479431004722 Domain of unknown function (DUF385); Region: DUF385; cl04387 479431004723 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431004724 Ligand Binding Site [chemical binding]; other site 479431004725 FOG: CBS domain [General function prediction only]; Region: COG0517 479431004726 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 479431004727 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431004728 Ligand Binding Site [chemical binding]; other site 479431004729 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431004730 Ligand Binding Site [chemical binding]; other site 479431004731 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431004732 Ligand Binding Site [chemical binding]; other site 479431004733 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 479431004734 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 479431004735 putative NAD(P) binding site [chemical binding]; other site 479431004736 putative substrate binding site [chemical binding]; other site 479431004737 catalytic Zn binding site [ion binding]; other site 479431004738 structural Zn binding site [ion binding]; other site 479431004739 Universal stress protein family; Region: Usp; pfam00582 479431004740 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431004741 Ligand Binding Site [chemical binding]; other site 479431004742 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431004743 Ligand Binding Site [chemical binding]; other site 479431004744 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431004745 Ligand Binding Site [chemical binding]; other site 479431004746 Copper resistance protein D; Region: CopD; pfam05425 479431004747 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 479431004748 Predicted acetyltransferase [General function prediction only]; Region: COG3153 479431004749 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 479431004750 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 479431004751 dimer interface [polypeptide binding]; other site 479431004752 ssDNA binding site [nucleotide binding]; other site 479431004753 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479431004754 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479431004755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431004756 DNA-binding site [nucleotide binding]; DNA binding site 479431004757 FCD domain; Region: FCD; pfam07729 479431004758 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 479431004759 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 479431004760 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 479431004761 Na binding site [ion binding]; other site 479431004762 putative substrate binding site [chemical binding]; other site 479431004763 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 479431004764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431004765 Walker A/P-loop; other site 479431004766 ATP binding site [chemical binding]; other site 479431004767 Q-loop/lid; other site 479431004768 ABC transporter signature motif; other site 479431004769 Walker B; other site 479431004770 D-loop; other site 479431004771 H-loop/switch region; other site 479431004772 ABC transporter; Region: ABC_tran_2; pfam12848 479431004773 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479431004774 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 479431004775 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 479431004776 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 479431004777 active site 479431004778 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 479431004779 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 479431004780 NodB motif; other site 479431004781 active site 479431004782 catalytic site [active] 479431004783 metal binding site [ion binding]; metal-binding site 479431004784 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 479431004785 apolar tunnel; other site 479431004786 heme binding site [chemical binding]; other site 479431004787 dimerization interface [polypeptide binding]; other site 479431004788 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 479431004789 Mechanosensitive ion channel; Region: MS_channel; pfam00924 479431004790 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 479431004791 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479431004792 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 479431004793 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 479431004794 Zn binding site [ion binding]; other site 479431004795 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 479431004796 catalytic residues [active] 479431004797 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431004798 Ligand Binding Site [chemical binding]; other site 479431004799 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 479431004800 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 479431004801 active site 479431004802 ADP/pyrophosphate binding site [chemical binding]; other site 479431004803 dimerization interface [polypeptide binding]; other site 479431004804 allosteric effector site; other site 479431004805 fructose-1,6-bisphosphate binding site; other site 479431004806 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 479431004807 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479431004808 DXD motif; other site 479431004809 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479431004810 E3 interaction surface; other site 479431004811 lipoyl attachment site [posttranslational modification]; other site 479431004812 HlyD family secretion protein; Region: HlyD_3; pfam13437 479431004813 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 479431004814 glucose-1-dehydrogenase; Provisional; Region: PRK08936 479431004815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431004816 NAD(P) binding site [chemical binding]; other site 479431004817 active site 479431004818 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 479431004819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479431004820 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479431004821 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479431004822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431004823 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 479431004824 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 479431004825 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 479431004826 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 479431004827 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 479431004828 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 479431004829 active site 479431004830 MarR family; Region: MarR_2; pfam12802 479431004831 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 479431004832 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431004833 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431004834 DNA binding site [nucleotide binding] 479431004835 domain linker motif; other site 479431004836 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431004837 dimerization interface [polypeptide binding]; other site 479431004838 ligand binding site [chemical binding]; other site 479431004839 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479431004840 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431004841 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479431004842 trigger factor; Provisional; Region: tig; PRK01490 479431004843 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 479431004844 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 479431004845 Clp protease; Region: CLP_protease; pfam00574 479431004846 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479431004847 oligomer interface [polypeptide binding]; other site 479431004848 active site residues [active] 479431004849 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 479431004850 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479431004851 oligomer interface [polypeptide binding]; other site 479431004852 active site residues [active] 479431004853 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 479431004854 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 479431004855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431004856 Walker A motif; other site 479431004857 ATP binding site [chemical binding]; other site 479431004858 Walker B motif; other site 479431004859 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 479431004860 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 479431004861 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479431004862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431004863 Coenzyme A binding pocket [chemical binding]; other site 479431004864 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 479431004865 Recombination protein O N terminal; Region: RecO_N; pfam11967 479431004866 Recombination protein O C terminal; Region: RecO_C; pfam02565 479431004867 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 479431004868 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 479431004869 catalytic residue [active] 479431004870 putative FPP diphosphate binding site; other site 479431004871 putative FPP binding hydrophobic cleft; other site 479431004872 dimer interface [polypeptide binding]; other site 479431004873 putative IPP diphosphate binding site; other site 479431004874 Predicted permeases [General function prediction only]; Region: COG0701 479431004875 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 479431004876 Fic/DOC family; Region: Fic; cl00960 479431004877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431004878 TIGR01777 family protein; Region: yfcH 479431004879 NAD(P) binding site [chemical binding]; other site 479431004880 active site 479431004881 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 479431004882 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479431004883 E3 interaction surface; other site 479431004884 lipoyl attachment site [posttranslational modification]; other site 479431004885 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479431004886 E3 interaction surface; other site 479431004887 lipoyl attachment site [posttranslational modification]; other site 479431004888 e3 binding domain; Region: E3_binding; pfam02817 479431004889 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479431004890 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 479431004891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431004892 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479431004893 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 479431004894 multifunctional aminopeptidase A; Provisional; Region: PRK00913 479431004895 interface (dimer of trimers) [polypeptide binding]; other site 479431004896 Substrate-binding/catalytic site; other site 479431004897 Zn-binding sites [ion binding]; other site 479431004898 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 479431004899 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 479431004900 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 479431004901 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 479431004902 homodimer interface [polypeptide binding]; other site 479431004903 substrate-cofactor binding pocket; other site 479431004904 catalytic residue [active] 479431004905 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 479431004906 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431004907 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431004908 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 479431004909 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 479431004910 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 479431004911 ssDNA binding site; other site 479431004912 generic binding surface II; other site 479431004913 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431004914 ATP binding site [chemical binding]; other site 479431004915 putative Mg++ binding site [ion binding]; other site 479431004916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431004917 nucleotide binding region [chemical binding]; other site 479431004918 ATP-binding site [chemical binding]; other site 479431004919 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479431004920 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479431004921 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 479431004922 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431004923 active site 479431004924 pyruvate carboxylase; Reviewed; Region: PRK12999 479431004925 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479431004926 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431004927 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 479431004928 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 479431004929 active site 479431004930 catalytic residues [active] 479431004931 metal binding site [ion binding]; metal-binding site 479431004932 homodimer binding site [polypeptide binding]; other site 479431004933 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 479431004934 carboxyltransferase (CT) interaction site; other site 479431004935 biotinylation site [posttranslational modification]; other site 479431004936 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 479431004937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431004938 S-adenosylmethionine binding site [chemical binding]; other site 479431004939 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 479431004940 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 479431004941 active site 479431004942 (T/H)XGH motif; other site 479431004943 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 479431004944 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 479431004945 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 479431004946 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 479431004947 ribonuclease III; Reviewed; Region: rnc; PRK00102 479431004948 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 479431004949 dimerization interface [polypeptide binding]; other site 479431004950 active site 479431004951 metal binding site [ion binding]; metal-binding site 479431004952 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 479431004953 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 479431004954 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 479431004955 DNA binding site [nucleotide binding] 479431004956 catalytic residue [active] 479431004957 H2TH interface [polypeptide binding]; other site 479431004958 putative catalytic residues [active] 479431004959 turnover-facilitating residue; other site 479431004960 intercalation triad [nucleotide binding]; other site 479431004961 8OG recognition residue [nucleotide binding]; other site 479431004962 putative reading head residues; other site 479431004963 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479431004964 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479431004965 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 479431004966 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 479431004967 putative lipid kinase; Reviewed; Region: PRK13057 479431004968 Integrase core domain; Region: rve; pfam00665 479431004969 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 479431004970 Acylphosphatase; Region: Acylphosphatase; cl00551 479431004971 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 479431004972 AAA domain; Region: AAA_23; pfam13476 479431004973 Walker A/P-loop; other site 479431004974 ATP binding site [chemical binding]; other site 479431004975 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 479431004976 ABC transporter signature motif; other site 479431004977 Walker B; other site 479431004978 D-loop; other site 479431004979 H-loop/switch region; other site 479431004980 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431004981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431004982 DNA binding residues [nucleotide binding] 479431004983 dimerization interface [polypeptide binding]; other site 479431004984 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 479431004985 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479431004986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431004987 Walker A motif; other site 479431004988 ATP binding site [chemical binding]; other site 479431004989 Walker B motif; other site 479431004990 arginine finger; other site 479431004991 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 479431004992 apolar tunnel; other site 479431004993 heme binding site [chemical binding]; other site 479431004994 dimerization interface [polypeptide binding]; other site 479431004995 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 479431004996 Phage-related protein [Function unknown]; Region: COG5412 479431004997 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 479431004998 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 479431004999 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 479431005000 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 479431005001 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479431005002 Phage protein D [General function prediction only]; Region: COG3500 479431005003 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 479431005004 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 479431005005 PAAR motif; Region: PAAR_motif; cl15808 479431005006 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 479431005007 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 479431005008 phage tail protein domain; Region: tail_TIGR02242 479431005009 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479431005010 YCII-related domain; Region: YCII; cl00999 479431005011 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 479431005012 active site 479431005013 NAD binding site [chemical binding]; other site 479431005014 metal binding site [ion binding]; metal-binding site 479431005015 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 479431005016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431005017 active site 479431005018 motif I; other site 479431005019 motif II; other site 479431005020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431005021 glutamine synthetase, type I; Region: GlnA; TIGR00653 479431005022 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 479431005023 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 479431005024 RDD family; Region: RDD; pfam06271 479431005025 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 479431005026 lipoyl synthase; Provisional; Region: PRK05481 479431005027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431005028 FeS/SAM binding site; other site 479431005029 lipoate-protein ligase B; Provisional; Region: PRK14345 479431005030 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479431005031 active site 479431005032 ATP binding site [chemical binding]; other site 479431005033 substrate binding site [chemical binding]; other site 479431005034 activation loop (A-loop); other site 479431005035 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 479431005036 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479431005037 active site 479431005038 metal binding site [ion binding]; metal-binding site 479431005039 DNA binding site [nucleotide binding] 479431005040 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 479431005041 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 479431005042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431005043 Walker A/P-loop; other site 479431005044 ATP binding site [chemical binding]; other site 479431005045 Q-loop/lid; other site 479431005046 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 479431005047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431005048 Walker B; other site 479431005049 D-loop; other site 479431005050 H-loop/switch region; other site 479431005051 glycyl-tRNA synthetase; Provisional; Region: PRK04173 479431005052 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479431005053 motif 1; other site 479431005054 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 479431005055 active site 479431005056 motif 2; other site 479431005057 motif 3; other site 479431005058 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 479431005059 anticodon binding site; other site 479431005060 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 479431005061 Zn binding site [ion binding]; other site 479431005062 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 479431005063 putative active site [active] 479431005064 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 479431005065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479431005066 Zn2+ binding site [ion binding]; other site 479431005067 Mg2+ binding site [ion binding]; other site 479431005068 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 479431005069 DNA primase, catalytic core; Region: dnaG; TIGR01391 479431005070 CHC2 zinc finger; Region: zf-CHC2; pfam01807 479431005071 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 479431005072 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 479431005073 active site 479431005074 metal binding site [ion binding]; metal-binding site 479431005075 interdomain interaction site; other site 479431005076 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 479431005077 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 479431005078 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479431005079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431005080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431005081 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479431005082 RibD C-terminal domain; Region: RibD_C; cl17279 479431005083 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 479431005084 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 479431005085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431005086 motif II; other site 479431005087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431005088 non-specific DNA binding site [nucleotide binding]; other site 479431005089 salt bridge; other site 479431005090 sequence-specific DNA binding site [nucleotide binding]; other site 479431005091 Helix-turn-helix domain; Region: HTH_17; cl17695 479431005092 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 479431005093 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 479431005094 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431005095 Helix-turn-helix domain; Region: HTH_19; pfam12844 479431005096 sequence-specific DNA binding site [nucleotide binding]; other site 479431005097 salt bridge; other site 479431005098 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 479431005099 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 479431005100 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 479431005101 dimer interface [polypeptide binding]; other site 479431005102 ssDNA binding site [nucleotide binding]; other site 479431005103 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479431005104 TrwC relaxase; Region: TrwC; pfam08751 479431005105 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 479431005106 AAA domain; Region: AAA_30; pfam13604 479431005107 Family description; Region: UvrD_C_2; pfam13538 479431005108 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431005109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431005110 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431005111 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 479431005112 cofactor binding site; other site 479431005113 DNA binding site [nucleotide binding] 479431005114 substrate interaction site [chemical binding]; other site 479431005115 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 479431005116 DEAD/DEAH box helicase; Region: DEAD; pfam00270 479431005117 ATP binding site [chemical binding]; other site 479431005118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431005119 nucleotide binding region [chemical binding]; other site 479431005120 ATP-binding site [chemical binding]; other site 479431005121 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 479431005122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431005123 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431005124 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 479431005125 Protein of unknown function DUF262; Region: DUF262; pfam03235 479431005126 Uncharacterized conserved protein [Function unknown]; Region: COG1479 479431005127 Uncharacterized conserved protein [Function unknown]; Region: COG3472 479431005128 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479431005129 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431005130 active site 479431005131 DNA binding site [nucleotide binding] 479431005132 Int/Topo IB signature motif; other site 479431005133 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 479431005134 putative hydrolase; Provisional; Region: PRK11460 479431005135 Predicted esterase [General function prediction only]; Region: COG0400 479431005136 Transposase domain (DUF772); Region: DUF772; pfam05598 479431005137 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431005138 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431005139 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 479431005140 thiamine pyrophosphate protein; Provisional; Region: PRK08273 479431005141 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 479431005142 PYR/PP interface [polypeptide binding]; other site 479431005143 dimer interface [polypeptide binding]; other site 479431005144 tetramer interface [polypeptide binding]; other site 479431005145 TPP binding site [chemical binding]; other site 479431005146 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479431005147 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 479431005148 TPP-binding site [chemical binding]; other site 479431005149 CAAX protease self-immunity; Region: Abi; pfam02517 479431005150 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 479431005151 SAP domain; Region: SAP; pfam02037 479431005152 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479431005153 GAF domain; Region: GAF_3; pfam13492 479431005154 GAF domain; Region: GAF_2; pfam13185 479431005155 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479431005156 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 479431005157 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 479431005158 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431005159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431005160 active site 479431005161 phosphorylation site [posttranslational modification] 479431005162 intermolecular recognition site; other site 479431005163 dimerization interface [polypeptide binding]; other site 479431005164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431005165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431005166 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479431005167 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479431005168 active site 479431005169 catalytic tetrad [active] 479431005170 short chain dehydrogenase; Provisional; Region: PRK06180 479431005171 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 479431005172 NADP binding site [chemical binding]; other site 479431005173 active site 479431005174 steroid binding site; other site 479431005175 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431005176 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 479431005177 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431005178 Ligand Binding Site [chemical binding]; other site 479431005179 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431005180 Ligand Binding Site [chemical binding]; other site 479431005181 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 479431005182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431005183 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 479431005184 Walker A/P-loop; other site 479431005185 ATP binding site [chemical binding]; other site 479431005186 Q-loop/lid; other site 479431005187 ABC transporter signature motif; other site 479431005188 Walker B; other site 479431005189 D-loop; other site 479431005190 H-loop/switch region; other site 479431005191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431005192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431005193 active site 479431005194 phosphorylation site [posttranslational modification] 479431005195 intermolecular recognition site; other site 479431005196 dimerization interface [polypeptide binding]; other site 479431005197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431005198 DNA binding residues [nucleotide binding] 479431005199 dimerization interface [polypeptide binding]; other site 479431005200 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479431005201 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 479431005202 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479431005203 GAF domain; Region: GAF_3; pfam13492 479431005204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431005205 Histidine kinase; Region: HisKA_3; pfam07730 479431005206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431005207 Mg2+ binding site [ion binding]; other site 479431005208 G-X-G motif; other site 479431005209 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431005210 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431005211 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479431005212 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479431005213 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479431005214 FAD binding domain; Region: FAD_binding_4; pfam01565 479431005215 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 479431005216 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 479431005217 Cysteine-rich domain; Region: CCG; pfam02754 479431005218 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431005219 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 479431005220 substrate binding site [chemical binding]; other site 479431005221 dimer interface [polypeptide binding]; other site 479431005222 ATP binding site [chemical binding]; other site 479431005223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431005224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431005225 active site 479431005226 phosphorylation site [posttranslational modification] 479431005227 intermolecular recognition site; other site 479431005228 dimerization interface [polypeptide binding]; other site 479431005229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431005230 DNA binding residues [nucleotide binding] 479431005231 dimerization interface [polypeptide binding]; other site 479431005232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431005233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431005234 ATP binding site [chemical binding]; other site 479431005235 Mg2+ binding site [ion binding]; other site 479431005236 G-X-G motif; other site 479431005237 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479431005238 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 479431005239 PAS domain; Region: PAS_8; pfam13188 479431005240 PAS domain; Region: PAS_9; pfam13426 479431005241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431005242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431005243 dimer interface [polypeptide binding]; other site 479431005244 phosphorylation site [posttranslational modification] 479431005245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431005246 ATP binding site [chemical binding]; other site 479431005247 Mg2+ binding site [ion binding]; other site 479431005248 G-X-G motif; other site 479431005249 Response regulator receiver domain; Region: Response_reg; pfam00072 479431005250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431005251 active site 479431005252 phosphorylation site [posttranslational modification] 479431005253 intermolecular recognition site; other site 479431005254 dimerization interface [polypeptide binding]; other site 479431005255 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431005256 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479431005257 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 479431005258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431005259 acyl-activating enzyme (AAE) consensus motif; other site 479431005260 AMP binding site [chemical binding]; other site 479431005261 active site 479431005262 CoA binding site [chemical binding]; other site 479431005263 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479431005264 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431005265 Carboxylesterase family; Region: COesterase; pfam00135 479431005266 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 479431005267 substrate binding pocket [chemical binding]; other site 479431005268 catalytic triad [active] 479431005269 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 479431005270 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431005271 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431005272 DNA binding residues [nucleotide binding] 479431005273 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479431005274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431005275 DNA-binding site [nucleotide binding]; DNA binding site 479431005276 FCD domain; Region: FCD; pfam07729 479431005277 allophanate hydrolase; Provisional; Region: PRK08186 479431005278 Amidase; Region: Amidase; cl11426 479431005279 Isochorismatase family; Region: Isochorismatase; pfam00857 479431005280 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 479431005281 catalytic triad [active] 479431005282 conserved cis-peptide bond; other site 479431005283 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 479431005284 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 479431005285 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 479431005286 active site 479431005287 metal binding site [ion binding]; metal-binding site 479431005288 nudix motif; other site 479431005289 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 479431005290 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431005291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431005292 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479431005293 putative dimerization interface [polypeptide binding]; other site 479431005294 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 479431005295 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479431005296 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479431005297 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 479431005298 catalytic triad [active] 479431005299 active site nucleophile [active] 479431005300 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 479431005301 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 479431005302 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 479431005303 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 479431005304 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 479431005305 dimer interface [polypeptide binding]; other site 479431005306 active site 479431005307 acyl carrier protein; Provisional; Region: acpP; PRK00982 479431005308 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 479431005309 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 479431005310 dimer interface [polypeptide binding]; other site 479431005311 active site 479431005312 CoA binding pocket [chemical binding]; other site 479431005313 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 479431005314 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 479431005315 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431005316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431005317 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431005318 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431005319 MULE transposase domain; Region: MULE; pfam10551 479431005320 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431005321 AAA domain; Region: AAA_22; pfam13401 479431005322 AAA ATPase domain; Region: AAA_16; pfam13191 479431005323 Walker A motif; other site 479431005324 ATP binding site [chemical binding]; other site 479431005325 Walker B motif; other site 479431005326 arginine finger; other site 479431005327 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431005328 MULE transposase domain; Region: MULE; pfam10551 479431005329 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479431005330 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 479431005331 DNA-binding site [nucleotide binding]; DNA binding site 479431005332 RNA-binding motif; other site 479431005333 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 479431005334 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 479431005335 dimer interface [polypeptide binding]; other site 479431005336 TPP-binding site [chemical binding]; other site 479431005337 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 479431005338 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 479431005339 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 479431005340 dimer interface [polypeptide binding]; other site 479431005341 catalytic triad [active] 479431005342 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 479431005343 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 479431005344 catalytic residues [active] 479431005345 catalytic nucleophile [active] 479431005346 Recombinase; Region: Recombinase; pfam07508 479431005347 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 479431005348 Domain of unknown function (DUF955); Region: DUF955; pfam06114 479431005349 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431005350 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431005351 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 479431005352 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 479431005353 MT-A70; Region: MT-A70; cl01947 479431005354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431005355 Transposase; Region: HTH_Tnp_1; cl17663 479431005356 putative transposase OrfB; Reviewed; Region: PHA02517 479431005357 HTH-like domain; Region: HTH_21; pfam13276 479431005358 Integrase core domain; Region: rve; pfam00665 479431005359 Integrase core domain; Region: rve_3; cl15866 479431005360 Replication-relaxation; Region: Replic_Relax; pfam13814 479431005361 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 479431005362 AAA-like domain; Region: AAA_10; pfam12846 479431005363 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 479431005364 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 479431005365 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431005366 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431005367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431005368 non-specific DNA binding site [nucleotide binding]; other site 479431005369 salt bridge; other site 479431005370 sequence-specific DNA binding site [nucleotide binding]; other site 479431005371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431005372 Integrase core domain; Region: rve; pfam00665 479431005373 transposase/IS protein; Provisional; Region: PRK09183 479431005374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431005375 Walker A motif; other site 479431005376 ATP binding site [chemical binding]; other site 479431005377 Walker B motif; other site 479431005378 Nicotinate phosphoribosyltransferase (NAPRTase) family; Region: NAPRTase; pfam04095 479431005379 Divergent AAA domain; Region: AAA_4; pfam04326 479431005380 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 479431005381 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431005382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431005383 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431005384 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 479431005385 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 479431005386 active site 479431005387 PAS domain; Region: PAS_9; pfam13426 479431005388 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 479431005389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479431005390 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 479431005391 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479431005392 anti sigma factor interaction site; other site 479431005393 regulatory phosphorylation site [posttranslational modification]; other site 479431005394 PAS fold; Region: PAS_3; pfam08447 479431005395 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479431005396 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479431005397 anti sigma factor interaction site; other site 479431005398 regulatory phosphorylation site [posttranslational modification]; other site 479431005399 Domain of unknown function (DUF305); Region: DUF305; pfam03713 479431005400 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 479431005401 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 479431005402 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 479431005403 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 479431005404 active site 479431005405 HIGH motif; other site 479431005406 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431005407 KMSK motif region; other site 479431005408 tRNA binding surface [nucleotide binding]; other site 479431005409 DALR anticodon binding domain; Region: DALR_1; smart00836 479431005410 anticodon binding site; other site 479431005411 diaminopimelate decarboxylase; Region: lysA; TIGR01048 479431005412 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 479431005413 active site 479431005414 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479431005415 substrate binding site [chemical binding]; other site 479431005416 catalytic residues [active] 479431005417 dimer interface [polypeptide binding]; other site 479431005418 homoserine dehydrogenase; Provisional; Region: PRK06349 479431005419 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 479431005420 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 479431005421 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479431005422 threonine synthase; Reviewed; Region: PRK06721 479431005423 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 479431005424 homodimer interface [polypeptide binding]; other site 479431005425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431005426 catalytic residue [active] 479431005427 homoserine kinase; Provisional; Region: PRK01212 479431005428 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 479431005429 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 479431005430 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 479431005431 transcription termination factor Rho; Provisional; Region: PRK12608 479431005432 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 479431005433 RNA binding site [nucleotide binding]; other site 479431005434 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 479431005435 Walker A motif; other site 479431005436 ATP binding site [chemical binding]; other site 479431005437 Walker B motif; other site 479431005438 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479431005439 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 479431005440 peptide chain release factor 1; Region: prfA; TIGR00019 479431005441 This domain is found in peptide chain release factors; Region: PCRF; smart00937 479431005442 RF-1 domain; Region: RF-1; pfam00472 479431005443 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 479431005444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431005445 S-adenosylmethionine binding site [chemical binding]; other site 479431005446 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 479431005447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431005448 sequence-specific DNA binding site [nucleotide binding]; other site 479431005449 salt bridge; other site 479431005450 Cupin domain; Region: Cupin_2; pfam07883 479431005451 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 479431005452 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479431005453 Walker A/P-loop; other site 479431005454 ATP binding site [chemical binding]; other site 479431005455 Q-loop/lid; other site 479431005456 ABC transporter signature motif; other site 479431005457 Walker B; other site 479431005458 D-loop; other site 479431005459 H-loop/switch region; other site 479431005460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431005461 Walker A/P-loop; other site 479431005462 ATP binding site [chemical binding]; other site 479431005463 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479431005464 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 479431005465 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479431005466 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479431005467 TM-ABC transporter signature motif; other site 479431005468 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479431005469 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479431005470 TM-ABC transporter signature motif; other site 479431005471 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 479431005472 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479431005473 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 479431005474 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 479431005475 active site 479431005476 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479431005477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431005478 NAD(P) binding site [chemical binding]; other site 479431005479 active site 479431005480 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479431005481 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 479431005482 tetramerization interface [polypeptide binding]; other site 479431005483 NAD(P) binding site [chemical binding]; other site 479431005484 catalytic residues [active] 479431005485 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431005486 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431005487 active site 479431005488 metal binding site [ion binding]; metal-binding site 479431005489 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 479431005490 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479431005491 tetramer interface [polypeptide binding]; other site 479431005492 TPP-binding site [chemical binding]; other site 479431005493 heterodimer interface [polypeptide binding]; other site 479431005494 phosphorylation loop region [posttranslational modification] 479431005495 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479431005496 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 479431005497 alpha subunit interface [polypeptide binding]; other site 479431005498 TPP binding site [chemical binding]; other site 479431005499 heterodimer interface [polypeptide binding]; other site 479431005500 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479431005501 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 479431005502 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479431005503 E3 interaction surface; other site 479431005504 lipoyl attachment site [posttranslational modification]; other site 479431005505 e3 binding domain; Region: E3_binding; pfam02817 479431005506 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479431005507 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 479431005508 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 479431005509 Mg++ binding site [ion binding]; other site 479431005510 putative catalytic motif [active] 479431005511 substrate binding site [chemical binding]; other site 479431005512 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 479431005513 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 479431005514 ATP synthase subunit C; Region: ATP-synt_C; cl00466 479431005515 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 479431005516 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 479431005517 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 479431005518 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 479431005519 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 479431005520 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 479431005521 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 479431005522 beta subunit interaction interface [polypeptide binding]; other site 479431005523 Walker A motif; other site 479431005524 ATP binding site [chemical binding]; other site 479431005525 Walker B motif; other site 479431005526 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 479431005527 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 479431005528 core domain interface [polypeptide binding]; other site 479431005529 delta subunit interface [polypeptide binding]; other site 479431005530 epsilon subunit interface [polypeptide binding]; other site 479431005531 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 479431005532 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 479431005533 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 479431005534 alpha subunit interaction interface [polypeptide binding]; other site 479431005535 Walker A motif; other site 479431005536 ATP binding site [chemical binding]; other site 479431005537 Walker B motif; other site 479431005538 inhibitor binding site; inhibition site 479431005539 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 479431005540 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 479431005541 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 479431005542 gamma subunit interface [polypeptide binding]; other site 479431005543 epsilon subunit interface [polypeptide binding]; other site 479431005544 LBP interface [polypeptide binding]; other site 479431005545 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 479431005546 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 479431005547 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 479431005548 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 479431005549 hinge; other site 479431005550 active site 479431005551 hypothetical protein; Provisional; Region: PRK03298 479431005552 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 479431005553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431005554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431005555 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 479431005556 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431005557 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 479431005558 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 479431005559 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 479431005560 ATP binding site [chemical binding]; other site 479431005561 substrate interface [chemical binding]; other site 479431005562 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 479431005563 active site residue [active] 479431005564 TIGR02569 family protein; Region: TIGR02569_actnb 479431005565 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 479431005566 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479431005567 active site 479431005568 DNA binding site [nucleotide binding] 479431005569 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 479431005570 Part of AAA domain; Region: AAA_19; pfam13245 479431005571 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 479431005572 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 479431005573 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 479431005574 Family description; Region: UvrD_C_2; pfam13538 479431005575 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 479431005576 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 479431005577 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 479431005578 dihydropteroate synthase; Region: DHPS; TIGR01496 479431005579 substrate binding pocket [chemical binding]; other site 479431005580 dimer interface [polypeptide binding]; other site 479431005581 inhibitor binding site; inhibition site 479431005582 DivIVA domain; Region: DivI1A_domain; TIGR03544 479431005583 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 479431005584 hydrophobic ligand binding site; other site 479431005585 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 479431005586 enoyl-CoA hydratase; Provisional; Region: PRK08140 479431005587 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479431005588 substrate binding site [chemical binding]; other site 479431005589 oxyanion hole (OAH) forming residues; other site 479431005590 trimer interface [polypeptide binding]; other site 479431005591 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 479431005592 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 479431005593 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479431005594 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 479431005595 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 479431005596 ligand binding site; other site 479431005597 oligomer interface; other site 479431005598 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 479431005599 dimer interface [polypeptide binding]; other site 479431005600 N-terminal domain interface [polypeptide binding]; other site 479431005601 sulfate 1 binding site; other site 479431005602 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 479431005603 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 479431005604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431005605 S-adenosylmethionine binding site [chemical binding]; other site 479431005606 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479431005607 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431005608 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431005609 DNA binding residues [nucleotide binding] 479431005610 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 479431005611 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 479431005612 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 479431005613 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 479431005614 Domain of unknown function DUF59; Region: DUF59; pfam01883 479431005615 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 479431005616 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 479431005617 Short C-terminal domain; Region: SHOCT; pfam09851 479431005618 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 479431005619 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 479431005620 oligomer interface [polypeptide binding]; other site 479431005621 metal binding site [ion binding]; metal-binding site 479431005622 metal binding site [ion binding]; metal-binding site 479431005623 putative Cl binding site [ion binding]; other site 479431005624 basic sphincter; other site 479431005625 hydrophobic gate; other site 479431005626 periplasmic entrance; other site 479431005627 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 479431005628 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 479431005629 active site 479431005630 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 479431005631 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 479431005632 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479431005633 ATP binding site [chemical binding]; other site 479431005634 Mg++ binding site [ion binding]; other site 479431005635 motif III; other site 479431005636 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431005637 nucleotide binding region [chemical binding]; other site 479431005638 ATP-binding site [chemical binding]; other site 479431005639 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 479431005640 dinuclear metal binding motif [ion binding]; other site 479431005641 Fructosamine kinase; Region: Fructosamin_kin; cl17579 479431005642 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 479431005643 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479431005644 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431005645 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 479431005646 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 479431005647 carboxyltransferase (CT) interaction site; other site 479431005648 biotinylation site [posttranslational modification]; other site 479431005649 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 479431005650 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 479431005651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431005652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431005653 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 479431005654 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 479431005655 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 479431005656 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 479431005657 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 479431005658 dimerization domain swap beta strand [polypeptide binding]; other site 479431005659 regulatory protein interface [polypeptide binding]; other site 479431005660 active site 479431005661 regulatory phosphorylation site [posttranslational modification]; other site 479431005662 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 479431005663 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 479431005664 putative substrate binding site [chemical binding]; other site 479431005665 putative ATP binding site [chemical binding]; other site 479431005666 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479431005667 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 479431005668 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 479431005669 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 479431005670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431005671 FeS/SAM binding site; other site 479431005672 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 479431005673 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 479431005674 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 479431005675 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 479431005676 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 479431005677 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 479431005678 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 479431005679 active site 479431005680 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 479431005681 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 479431005682 putative substrate binding region [chemical binding]; other site 479431005683 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 479431005684 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 479431005685 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 479431005686 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 479431005687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479431005688 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 479431005689 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479431005690 active site 479431005691 dimer interface [polypeptide binding]; other site 479431005692 Tubby C 2; Region: Tub_2; cl02043 479431005693 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 479431005694 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 479431005695 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 479431005696 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 479431005697 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479431005698 active site 479431005699 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479431005700 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 479431005701 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 479431005702 metal ion-dependent adhesion site (MIDAS); other site 479431005703 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479431005704 DNA binding site [nucleotide binding] 479431005705 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479431005706 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 479431005707 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479431005708 phosphopeptide binding site; other site 479431005709 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 479431005710 mycothione reductase; Reviewed; Region: PRK07846 479431005711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431005712 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479431005713 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 479431005714 substrate binding site [chemical binding]; other site 479431005715 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 479431005716 ATP binding site [chemical binding]; other site 479431005717 putative acyltransferase; Provisional; Region: PRK05790 479431005718 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479431005719 dimer interface [polypeptide binding]; other site 479431005720 active site 479431005721 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431005722 prolyl-tRNA synthetase; Provisional; Region: PRK09194 479431005723 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 479431005724 dimer interface [polypeptide binding]; other site 479431005725 motif 1; other site 479431005726 active site 479431005727 motif 2; other site 479431005728 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 479431005729 putative deacylase active site [active] 479431005730 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479431005731 active site 479431005732 motif 3; other site 479431005733 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 479431005734 anticodon binding site; other site 479431005735 ribosome maturation protein RimP; Reviewed; Region: PRK00092 479431005736 Sm and related proteins; Region: Sm_like; cl00259 479431005737 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 479431005738 putative oligomer interface [polypeptide binding]; other site 479431005739 putative RNA binding site [nucleotide binding]; other site 479431005740 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 479431005741 NusA N-terminal domain; Region: NusA_N; pfam08529 479431005742 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 479431005743 RNA binding site [nucleotide binding]; other site 479431005744 homodimer interface [polypeptide binding]; other site 479431005745 NusA-like KH domain; Region: KH_5; pfam13184 479431005746 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 479431005747 G-X-X-G motif; other site 479431005748 Protein of unknown function (DUF448); Region: DUF448; pfam04296 479431005749 putative RNA binding cleft [nucleotide binding]; other site 479431005750 translation initiation factor IF-2; Region: IF-2; TIGR00487 479431005751 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 479431005752 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 479431005753 G1 box; other site 479431005754 putative GEF interaction site [polypeptide binding]; other site 479431005755 GTP/Mg2+ binding site [chemical binding]; other site 479431005756 Switch I region; other site 479431005757 G2 box; other site 479431005758 G3 box; other site 479431005759 Switch II region; other site 479431005760 G4 box; other site 479431005761 G5 box; other site 479431005762 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 479431005763 Translation-initiation factor 2; Region: IF-2; pfam11987 479431005764 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 479431005765 Protein of unknown function (DUF503); Region: DUF503; pfam04456 479431005766 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 479431005767 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 479431005768 DHH family; Region: DHH; pfam01368 479431005769 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479431005770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431005771 DNA-binding site [nucleotide binding]; DNA binding site 479431005772 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 479431005773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431005774 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431005775 putative substrate translocation pore; other site 479431005776 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 479431005777 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 479431005778 RNA binding site [nucleotide binding]; other site 479431005779 active site 479431005780 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 479431005781 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 479431005782 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 479431005783 active site 479431005784 Riboflavin kinase; Region: Flavokinase; pfam01687 479431005785 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 479431005786 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 479431005787 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 479431005788 transmembrane helices; other site 479431005789 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 479431005790 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431005791 Ligand Binding Site [chemical binding]; other site 479431005792 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 479431005793 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479431005794 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 479431005795 16S/18S rRNA binding site [nucleotide binding]; other site 479431005796 S13e-L30e interaction site [polypeptide binding]; other site 479431005797 25S rRNA binding site [nucleotide binding]; other site 479431005798 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 479431005799 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 479431005800 oligomer interface [polypeptide binding]; other site 479431005801 RNA binding site [nucleotide binding]; other site 479431005802 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 479431005803 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 479431005804 RNase E interface [polypeptide binding]; other site 479431005805 trimer interface [polypeptide binding]; other site 479431005806 active site 479431005807 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 479431005808 putative nucleic acid binding region [nucleotide binding]; other site 479431005809 G-X-X-G motif; other site 479431005810 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 479431005811 RNA binding site [nucleotide binding]; other site 479431005812 domain interface; other site 479431005813 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 479431005814 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 479431005815 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479431005816 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 479431005817 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479431005818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431005819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431005820 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479431005821 putative dimerization interface [polypeptide binding]; other site 479431005822 dihydrodipicolinate reductase; Provisional; Region: PRK00048 479431005823 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 479431005824 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 479431005825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431005826 Coenzyme A binding pocket [chemical binding]; other site 479431005827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 479431005828 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479431005829 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 479431005830 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 479431005831 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431005832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431005833 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431005834 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 479431005835 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 479431005836 HicB family; Region: HicB; pfam05534 479431005837 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 479431005838 Ferritin-like domain; Region: Ferritin; pfam00210 479431005839 ferroxidase diiron center [ion binding]; other site 479431005840 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 479431005841 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 479431005842 active site 479431005843 catalytic triad [active] 479431005844 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 479431005845 PA/protease or protease-like domain interface [polypeptide binding]; other site 479431005846 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479431005847 catalytic residues [active] 479431005848 TIGR03085 family protein; Region: TIGR03085 479431005849 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479431005850 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479431005851 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 479431005852 dimer interface [polypeptide binding]; other site 479431005853 active site 479431005854 catalytic residue [active] 479431005855 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 479431005856 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479431005857 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 479431005858 Protein of unknown function (DUF952); Region: DUF952; pfam06108 479431005859 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 479431005860 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 479431005861 molybdopterin cofactor binding site; other site 479431005862 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 479431005863 molybdopterin cofactor binding site; other site 479431005864 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 479431005865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431005866 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 479431005867 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479431005868 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 479431005869 iron-sulfur cluster [ion binding]; other site 479431005870 [2Fe-2S] cluster binding site [ion binding]; other site 479431005871 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 479431005872 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 479431005873 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 479431005874 active site 479431005875 SAM binding site [chemical binding]; other site 479431005876 homodimer interface [polypeptide binding]; other site 479431005877 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479431005878 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479431005879 Ion channel; Region: Ion_trans_2; pfam07885 479431005880 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 479431005881 TrkA-N domain; Region: TrkA_N; pfam02254 479431005882 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 479431005883 TrkA-N domain; Region: TrkA_N; pfam02254 479431005884 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 479431005885 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 479431005886 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 479431005887 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 479431005888 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479431005889 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 479431005890 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431005891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431005892 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431005893 malate dehydrogenase; Provisional; Region: PRK05442 479431005894 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 479431005895 NAD(P) binding site [chemical binding]; other site 479431005896 dimer interface [polypeptide binding]; other site 479431005897 malate binding site [chemical binding]; other site 479431005898 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 479431005899 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 479431005900 putative active site [active] 479431005901 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 479431005902 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 479431005903 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 479431005904 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 479431005905 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 479431005906 putative active site [active] 479431005907 catalytic residue [active] 479431005908 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 479431005909 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 479431005910 TPP-binding site [chemical binding]; other site 479431005911 dimer interface [polypeptide binding]; other site 479431005912 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 479431005913 PYR/PP interface [polypeptide binding]; other site 479431005914 dimer interface [polypeptide binding]; other site 479431005915 TPP binding site [chemical binding]; other site 479431005916 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479431005917 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 479431005918 UbiA prenyltransferase family; Region: UbiA; pfam01040 479431005919 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 479431005920 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 479431005921 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479431005922 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479431005923 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431005924 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431005925 Walker A/P-loop; other site 479431005926 ATP binding site [chemical binding]; other site 479431005927 Q-loop/lid; other site 479431005928 ABC transporter signature motif; other site 479431005929 Walker B; other site 479431005930 D-loop; other site 479431005931 H-loop/switch region; other site 479431005932 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479431005933 hydrophobic ligand binding site; other site 479431005934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431005935 dimerization interface [polypeptide binding]; other site 479431005936 putative DNA binding site [nucleotide binding]; other site 479431005937 putative Zn2+ binding site [ion binding]; other site 479431005938 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 479431005939 active site 479431005940 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 479431005941 Predicted transcriptional regulator [Transcription]; Region: COG2345 479431005942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431005943 putative DNA binding site [nucleotide binding]; other site 479431005944 putative Zn2+ binding site [ion binding]; other site 479431005945 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 479431005946 FeS assembly protein SufB; Region: sufB; TIGR01980 479431005947 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 479431005948 FeS assembly protein SufD; Region: sufD; TIGR01981 479431005949 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 479431005950 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 479431005951 Walker A/P-loop; other site 479431005952 ATP binding site [chemical binding]; other site 479431005953 Q-loop/lid; other site 479431005954 ABC transporter signature motif; other site 479431005955 Walker B; other site 479431005956 D-loop; other site 479431005957 H-loop/switch region; other site 479431005958 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479431005959 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 479431005960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431005961 catalytic residue [active] 479431005962 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 479431005963 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 479431005964 trimerization site [polypeptide binding]; other site 479431005965 active site 479431005966 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 479431005967 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 479431005968 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 479431005969 active site 479431005970 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 479431005971 DNA binding site [nucleotide binding] 479431005972 Cupin; Region: Cupin_1; smart00835 479431005973 Cupin; Region: Cupin_1; smart00835 479431005974 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 479431005975 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 479431005976 active site 479431005977 catalytic residues [active] 479431005978 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479431005979 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 479431005980 HD domain; Region: HD; pfam01966 479431005981 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 479431005982 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 479431005983 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 479431005984 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 479431005985 RNA binding site [nucleotide binding]; other site 479431005986 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479431005987 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479431005988 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479431005989 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479431005990 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 479431005991 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479431005992 substrate binding site [chemical binding]; other site 479431005993 oxyanion hole (OAH) forming residues; other site 479431005994 trimer interface [polypeptide binding]; other site 479431005995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431005996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431005997 aconitate hydratase; Validated; Region: PRK09277 479431005998 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 479431005999 substrate binding site [chemical binding]; other site 479431006000 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 479431006001 ligand binding site [chemical binding]; other site 479431006002 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 479431006003 substrate binding site [chemical binding]; other site 479431006004 Excalibur calcium-binding domain; Region: Excalibur; smart00894 479431006005 Excalibur calcium-binding domain; Region: Excalibur; smart00894 479431006006 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 479431006007 NlpC/P60 family; Region: NLPC_P60; pfam00877 479431006008 MoxR-like ATPases [General function prediction only]; Region: COG0714 479431006009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431006010 Walker A motif; other site 479431006011 ATP binding site [chemical binding]; other site 479431006012 Walker B motif; other site 479431006013 arginine finger; other site 479431006014 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479431006015 Protein of unknown function DUF58; Region: DUF58; pfam01882 479431006016 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 479431006017 hypothetical protein; Provisional; Region: PRK13685 479431006018 von Willebrand factor type A domain; Region: VWA_2; pfam13519 479431006019 metal ion-dependent adhesion site (MIDAS); other site 479431006020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431006021 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 479431006022 NAD(P) binding site [chemical binding]; other site 479431006023 active site 479431006024 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 479431006025 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 479431006026 NAD binding site [chemical binding]; other site 479431006027 homotetramer interface [polypeptide binding]; other site 479431006028 homodimer interface [polypeptide binding]; other site 479431006029 substrate binding site [chemical binding]; other site 479431006030 active site 479431006031 Predicted transcriptional regulators [Transcription]; Region: COG1725 479431006032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431006033 DNA-binding site [nucleotide binding]; DNA binding site 479431006034 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431006035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431006036 Walker A/P-loop; other site 479431006037 ATP binding site [chemical binding]; other site 479431006038 Q-loop/lid; other site 479431006039 ABC transporter signature motif; other site 479431006040 Walker B; other site 479431006041 D-loop; other site 479431006042 H-loop/switch region; other site 479431006043 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 479431006044 Protein of unknown function (DUF466); Region: DUF466; pfam04328 479431006045 carbon starvation protein A; Provisional; Region: PRK15015 479431006046 Carbon starvation protein CstA; Region: CstA; pfam02554 479431006047 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 479431006048 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 479431006049 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 479431006050 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 479431006051 Uncharacterized conserved protein [Function unknown]; Region: COG5495 479431006052 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 479431006053 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431006054 active site 479431006055 nucleotide binding site [chemical binding]; other site 479431006056 HIGH motif; other site 479431006057 KMSKS motif; other site 479431006058 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431006059 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431006060 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431006061 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431006062 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 479431006063 oligomerization interface [polypeptide binding]; other site 479431006064 active site 479431006065 metal binding site [ion binding]; metal-binding site 479431006066 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 479431006067 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 479431006068 metal binding site [ion binding]; metal-binding site 479431006069 dimer interface [polypeptide binding]; other site 479431006070 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 479431006071 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 479431006072 cleavage site 479431006073 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479431006074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431006075 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431006076 MarR family; Region: MarR_2; pfam12802 479431006077 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479431006078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 479431006079 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 479431006080 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 479431006081 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 479431006082 ligand binding site; other site 479431006083 oligomer interface; other site 479431006084 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 479431006085 N-terminal domain interface [polypeptide binding]; other site 479431006086 sulfate 1 binding site; other site 479431006087 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 479431006088 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479431006089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431006090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431006091 Uncharacterized conserved protein [Function unknown]; Region: COG1359 479431006092 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 479431006093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431006094 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431006095 active site 479431006096 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 479431006097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 479431006098 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479431006099 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431006100 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479431006101 DNA binding residues [nucleotide binding] 479431006102 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 479431006103 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 479431006104 Hexamer interface [polypeptide binding]; other site 479431006105 Hexagonal pore residue; other site 479431006106 GAF domain; Region: GAF_2; pfam13185 479431006107 GAF domain; Region: GAF_3; pfam13492 479431006108 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479431006109 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 479431006110 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431006111 catalytic Zn binding site [ion binding]; other site 479431006112 NAD(P) binding site [chemical binding]; other site 479431006113 structural Zn binding site [ion binding]; other site 479431006114 malate dehydrogenase, NAD-dependent; Region: MalateDH_bact; TIGR01763 479431006115 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 479431006116 NAD(P) binding site [chemical binding]; other site 479431006117 LDH/MDH dimer interface [polypeptide binding]; other site 479431006118 substrate binding site [chemical binding]; other site 479431006119 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 479431006120 putative hexamer interface [polypeptide binding]; other site 479431006121 putative hexagonal pore; other site 479431006122 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 479431006123 putative hexamer interface [polypeptide binding]; other site 479431006124 putative hexagonal pore; other site 479431006125 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 479431006126 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 479431006127 putative catalytic cysteine [active] 479431006128 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 479431006129 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 479431006130 Hexamer interface [polypeptide binding]; other site 479431006131 Hexagonal pore residue; other site 479431006132 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cl01889 479431006133 Hexamer/Pentamer interface [polypeptide binding]; other site 479431006134 central pore; other site 479431006135 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479431006136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431006137 motif II; other site 479431006138 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 479431006139 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 479431006140 active site 479431006141 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479431006142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431006143 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 479431006144 classical (c) SDRs; Region: SDR_c; cd05233 479431006145 NAD(P) binding site [chemical binding]; other site 479431006146 active site 479431006147 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 479431006148 classical (c) SDRs; Region: SDR_c; cd05233 479431006149 NAD(P) binding site [chemical binding]; other site 479431006150 active site 479431006151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431006152 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 479431006153 Walker A motif; other site 479431006154 ATP binding site [chemical binding]; other site 479431006155 Walker B motif; other site 479431006156 von Willebrand factor type A domain; Region: VWA_2; pfam13519 479431006157 metal ion-dependent adhesion site (MIDAS); other site 479431006158 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 479431006159 beta-alpha-beta structure motif; other site 479431006160 NAD binding pocket [chemical binding]; other site 479431006161 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 479431006162 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 479431006163 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 479431006164 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 479431006165 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431006166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431006167 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431006168 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479431006169 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479431006170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431006171 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479431006172 Walker A/P-loop; other site 479431006173 ATP binding site [chemical binding]; other site 479431006174 Q-loop/lid; other site 479431006175 ABC transporter signature motif; other site 479431006176 Walker B; other site 479431006177 D-loop; other site 479431006178 H-loop/switch region; other site 479431006179 EXLDI protein; Region: EXLDI; TIGR04342 479431006180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431006181 S-adenosylmethionine binding site [chemical binding]; other site 479431006182 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431006183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431006184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431006185 DNA binding residues [nucleotide binding] 479431006186 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431006187 M6 family metalloprotease domain; Region: M6dom_TIGR03296 479431006188 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 479431006189 AAA ATPase domain; Region: AAA_16; pfam13191 479431006190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431006191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431006192 DNA binding residues [nucleotide binding] 479431006193 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 479431006194 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 479431006195 active site 479431006196 catalytic residues [active] 479431006197 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 479431006198 putative hydrophobic ligand binding site [chemical binding]; other site 479431006199 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479431006200 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431006201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 479431006202 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 479431006203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431006204 Walker A/P-loop; other site 479431006205 ATP binding site [chemical binding]; other site 479431006206 Q-loop/lid; other site 479431006207 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 479431006208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431006209 ABC transporter signature motif; other site 479431006210 Walker B; other site 479431006211 D-loop; other site 479431006212 H-loop/switch region; other site 479431006213 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 479431006214 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 479431006215 active site 479431006216 metal binding site [ion binding]; metal-binding site 479431006217 DNA binding site [nucleotide binding] 479431006218 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 479431006219 HerA helicase [Replication, recombination, and repair]; Region: COG0433 479431006220 Excalibur calcium-binding domain; Region: Excalibur; smart00894 479431006221 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 479431006222 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431006223 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431006224 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431006225 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431006226 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479431006227 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479431006228 active site 479431006229 catalytic tetrad [active] 479431006230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431006231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431006232 active site 479431006233 ATP binding site [chemical binding]; other site 479431006234 substrate binding site [chemical binding]; other site 479431006235 activation loop (A-loop); other site 479431006236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 479431006237 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431006238 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431006239 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431006240 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431006241 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 479431006242 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431006243 acyl-activating enzyme (AAE) consensus motif; other site 479431006244 AMP binding site [chemical binding]; other site 479431006245 active site 479431006246 CoA binding site [chemical binding]; other site 479431006247 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 479431006248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431006249 active site 479431006250 phosphorylation site [posttranslational modification] 479431006251 intermolecular recognition site; other site 479431006252 dimerization interface [polypeptide binding]; other site 479431006253 ANTAR domain; Region: ANTAR; pfam03861 479431006254 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431006255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431006256 DNA binding residues [nucleotide binding] 479431006257 dimerization interface [polypeptide binding]; other site 479431006258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431006259 S-adenosylmethionine binding site [chemical binding]; other site 479431006260 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 479431006261 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 479431006262 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479431006263 DNA binding residues [nucleotide binding] 479431006264 putative dimer interface [polypeptide binding]; other site 479431006265 FOG: CBS domain [General function prediction only]; Region: COG0517 479431006266 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 479431006267 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 479431006268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431006269 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479431006270 NAD(P) binding site [chemical binding]; other site 479431006271 active site 479431006272 SWIM zinc finger; Region: SWIM; pfam04434 479431006273 MoxR-like ATPases [General function prediction only]; Region: COG0714 479431006274 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 479431006275 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 479431006276 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 479431006277 metal ion-dependent adhesion site (MIDAS); other site 479431006278 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 479431006279 tandem repeat interface [polypeptide binding]; other site 479431006280 oligomer interface [polypeptide binding]; other site 479431006281 active site residues [active] 479431006282 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 479431006283 tandem repeat interface [polypeptide binding]; other site 479431006284 oligomer interface [polypeptide binding]; other site 479431006285 active site residues [active] 479431006286 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479431006287 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 479431006288 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 479431006289 FAD binding pocket [chemical binding]; other site 479431006290 FAD binding motif [chemical binding]; other site 479431006291 phosphate binding motif [ion binding]; other site 479431006292 beta-alpha-beta structure motif; other site 479431006293 NAD binding pocket [chemical binding]; other site 479431006294 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479431006295 catalytic loop [active] 479431006296 iron binding site [ion binding]; other site 479431006297 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 479431006298 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 479431006299 putative di-iron ligands [ion binding]; other site 479431006300 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 479431006301 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479431006302 active site 479431006303 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 479431006304 CHY zinc finger; Region: zf-CHY; pfam05495 479431006305 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 479431006306 N-terminal domain of the plant and fungal Nei and related proteins; Region: PF_Nei_N; cd08972 479431006307 putative DNA binding site [nucleotide binding]; other site 479431006308 catalytic residue [active] 479431006309 putative H2TH interface [polypeptide binding]; other site 479431006310 putative catalytic residues [active] 479431006311 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479431006312 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431006313 Coenzyme A binding pocket [chemical binding]; other site 479431006314 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 479431006315 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431006316 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479431006317 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479431006318 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479431006319 Walker A/P-loop; other site 479431006320 ATP binding site [chemical binding]; other site 479431006321 Q-loop/lid; other site 479431006322 ABC transporter signature motif; other site 479431006323 Walker B; other site 479431006324 D-loop; other site 479431006325 H-loop/switch region; other site 479431006326 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479431006327 dimer interface [polypeptide binding]; other site 479431006328 putative PBP binding regions; other site 479431006329 ABC-ATPase subunit interface; other site 479431006330 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 479431006331 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479431006332 ABC-ATPase subunit interface; other site 479431006333 dimer interface [polypeptide binding]; other site 479431006334 putative PBP binding regions; other site 479431006335 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479431006336 hydrophobic ligand binding site; other site 479431006337 Lsr2; Region: Lsr2; pfam11774 479431006338 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 479431006339 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 479431006340 putative DNA binding site [nucleotide binding]; other site 479431006341 catalytic residue [active] 479431006342 putative H2TH interface [polypeptide binding]; other site 479431006343 putative catalytic residues [active] 479431006344 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479431006345 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479431006346 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 479431006347 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431006348 substrate binding site [chemical binding]; other site 479431006349 ATP binding site [chemical binding]; other site 479431006350 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 479431006351 active site 479431006352 intersubunit interface [polypeptide binding]; other site 479431006353 catalytic residue [active] 479431006354 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 479431006355 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 479431006356 dimer interface [polypeptide binding]; other site 479431006357 active site 479431006358 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479431006359 substrate binding site [chemical binding]; other site 479431006360 catalytic residue [active] 479431006361 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479431006362 homotrimer interaction site [polypeptide binding]; other site 479431006363 putative active site [active] 479431006364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 479431006365 YheO-like PAS domain; Region: PAS_6; pfam08348 479431006366 HTH domain; Region: HTH_22; pfam13309 479431006367 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 479431006368 RNA/DNA hybrid binding site [nucleotide binding]; other site 479431006369 active site 479431006370 Uncharacterized conserved protein [Function unknown]; Region: COG0397 479431006371 hypothetical protein; Validated; Region: PRK00029 479431006372 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 479431006373 Flavodoxin domain; Region: Flavodoxin_5; cl17428 479431006374 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431006375 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 479431006376 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431006377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 479431006378 active site 479431006379 phosphorylation site [posttranslational modification] 479431006380 intermolecular recognition site; other site 479431006381 dimerization interface [polypeptide binding]; other site 479431006382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431006383 DNA binding residues [nucleotide binding] 479431006384 dimerization interface [polypeptide binding]; other site 479431006385 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 479431006386 hydrophobic ligand binding site; other site 479431006387 TAP-like protein; Region: Abhydrolase_4; pfam08386 479431006388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431006389 ATP binding site [chemical binding]; other site 479431006390 Mg2+ binding site [ion binding]; other site 479431006391 G-X-G motif; other site 479431006392 putative transposase OrfB; Reviewed; Region: PHA02517 479431006393 HTH-like domain; Region: HTH_21; pfam13276 479431006394 Integrase core domain; Region: rve; pfam00665 479431006395 Integrase core domain; Region: rve_3; pfam13683 479431006396 Transposase domain (DUF772); Region: DUF772; pfam05598 479431006397 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431006398 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431006399 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 479431006400 FOG: CBS domain [General function prediction only]; Region: COG0517 479431006401 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 479431006402 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 479431006403 CoA binding domain; Region: CoA_binding_2; pfam13380 479431006404 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 479431006405 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 479431006406 high affinity sulphate transporter 1; Region: sulP; TIGR00815 479431006407 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 479431006408 Sulfate transporter family; Region: Sulfate_transp; pfam00916 479431006409 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 479431006410 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 479431006411 2TM domain; Region: 2TM; pfam13239 479431006412 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 479431006413 Acyltransferase family; Region: Acyl_transf_3; pfam01757 479431006414 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 479431006415 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 479431006416 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479431006417 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 479431006418 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479431006419 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479431006420 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 479431006421 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479431006422 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 479431006423 Predicted permease [General function prediction only]; Region: COG2985 479431006424 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 479431006425 TrkA-C domain; Region: TrkA_C; pfam02080 479431006426 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 479431006427 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 479431006428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479431006429 polyol permease family; Region: 2A0118; TIGR00897 479431006430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431006431 putative substrate translocation pore; other site 479431006432 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431006433 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479431006434 NAD(P) binding site [chemical binding]; other site 479431006435 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431006436 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431006437 active site 479431006438 ATP binding site [chemical binding]; other site 479431006439 substrate binding site [chemical binding]; other site 479431006440 activation loop (A-loop); other site 479431006441 Uncharacterized conserved protein [Function unknown]; Region: COG3391 479431006442 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 479431006443 structural tetrad; other site 479431006444 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 479431006445 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 479431006446 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 479431006447 classical (c) SDRs; Region: SDR_c; cd05233 479431006448 NAD(P) binding site [chemical binding]; other site 479431006449 active site 479431006450 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 479431006451 putative active site [active] 479431006452 putative substrate binding site [chemical binding]; other site 479431006453 ATP binding site [chemical binding]; other site 479431006454 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431006455 active site 479431006456 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 479431006457 apolar tunnel; other site 479431006458 heme binding site [chemical binding]; other site 479431006459 dimerization interface [polypeptide binding]; other site 479431006460 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 479431006461 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431006462 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 479431006463 CoenzymeA binding site [chemical binding]; other site 479431006464 subunit interaction site [polypeptide binding]; other site 479431006465 PHB binding site; other site 479431006466 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 479431006467 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479431006468 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479431006469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431006470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431006471 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 479431006472 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 479431006473 substrate binding site [chemical binding]; other site 479431006474 dimer interface [polypeptide binding]; other site 479431006475 NADP binding site [chemical binding]; other site 479431006476 catalytic residues [active] 479431006477 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 479431006478 active site 2 [active] 479431006479 active site 1 [active] 479431006480 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 479431006481 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 479431006482 FAD binding pocket [chemical binding]; other site 479431006483 FAD binding motif [chemical binding]; other site 479431006484 phosphate binding motif [ion binding]; other site 479431006485 beta-alpha-beta structure motif; other site 479431006486 NAD(p) ribose binding residues [chemical binding]; other site 479431006487 NAD binding pocket [chemical binding]; other site 479431006488 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 479431006489 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479431006490 catalytic loop [active] 479431006491 iron binding site [ion binding]; other site 479431006492 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 479431006493 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 479431006494 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 479431006495 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 479431006496 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 479431006497 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 479431006498 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479431006499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431006500 NAD(P) binding site [chemical binding]; other site 479431006501 active site 479431006502 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479431006503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431006504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431006505 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479431006506 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479431006507 putative acyl-acceptor binding pocket; other site 479431006508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479431006509 active site 479431006510 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479431006511 Cytochrome P450; Region: p450; cl12078 479431006512 Cytochrome P450; Region: p450; cl12078 479431006513 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 479431006514 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 479431006515 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 479431006516 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 479431006517 active site lid residues [active] 479431006518 substrate binding pocket [chemical binding]; other site 479431006519 catalytic residues [active] 479431006520 substrate-Mg2+ binding site; other site 479431006521 aspartate-rich region 1; other site 479431006522 aspartate-rich region 2; other site 479431006523 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431006524 phytoene desaturase; Region: crtI_fam; TIGR02734 479431006525 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 479431006526 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 479431006527 substrate binding pocket [chemical binding]; other site 479431006528 chain length determination region; other site 479431006529 substrate-Mg2+ binding site; other site 479431006530 catalytic residues [active] 479431006531 aspartate-rich region 1; other site 479431006532 active site lid residues [active] 479431006533 aspartate-rich region 2; other site 479431006534 sugar efflux transporter B; Provisional; Region: PRK15011 479431006535 helicase superfamily c-terminal domain; Region: HELICc; smart00490 479431006536 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 479431006537 nucleotide binding region [chemical binding]; other site 479431006538 ATP-binding site [chemical binding]; other site 479431006539 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 479431006540 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 479431006541 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431006542 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431006543 active site 479431006544 catalytic residues [active] 479431006545 DNA binding site [nucleotide binding] 479431006546 Int/Topo IB signature motif; other site 479431006547 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 479431006548 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431006549 active site 479431006550 DNA binding site [nucleotide binding] 479431006551 Int/Topo IB signature motif; other site 479431006552 putative transposase OrfB; Reviewed; Region: PHA02517 479431006553 HTH-like domain; Region: HTH_21; pfam13276 479431006554 Integrase core domain; Region: rve; pfam00665 479431006555 Integrase core domain; Region: rve_3; pfam13683 479431006556 Transcription factor WhiB; Region: Whib; pfam02467 479431006557 putative transposase OrfB; Reviewed; Region: PHA02517 479431006558 HTH-like domain; Region: HTH_21; pfam13276 479431006559 Integrase core domain; Region: rve; pfam00665 479431006560 Integrase core domain; Region: rve_3; pfam13683 479431006561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431006562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431006563 transposase/IS protein; Provisional; Region: PRK09183 479431006564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431006565 Walker A motif; other site 479431006566 ATP binding site [chemical binding]; other site 479431006567 Walker B motif; other site 479431006568 DDE superfamily endonuclease; Region: DDE_5; pfam13546 479431006569 Homeodomain-like domain; Region: HTH_23; pfam13384 479431006570 Winged helix-turn helix; Region: HTH_29; pfam13551 479431006571 Homeodomain-like domain; Region: HTH_32; pfam13565 479431006572 DDE superfamily endonuclease; Region: DDE_3; pfam13358 479431006573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 479431006574 DDE superfamily endonuclease; Region: DDE_5; pfam13546 479431006575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479431006576 binding surface 479431006577 TPR motif; other site 479431006578 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479431006579 Integrase core domain; Region: rve; pfam00665 479431006580 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 479431006581 MarR family; Region: MarR_2; pfam12802 479431006582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431006583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431006584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479431006585 dimerization interface [polypeptide binding]; other site 479431006586 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 479431006587 Predicted permeases [General function prediction only]; Region: COG0701 479431006588 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431006589 dimerization interface [polypeptide binding]; other site 479431006590 putative DNA binding site [nucleotide binding]; other site 479431006591 putative Zn2+ binding site [ion binding]; other site 479431006592 OsmC-like protein; Region: OsmC; pfam02566 479431006593 Integrase core domain; Region: rve; pfam00665 479431006594 Integrase core domain; Region: rve_3; pfam13683 479431006595 DsrC like protein; Region: DsrC; pfam04358 479431006596 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 479431006597 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 479431006598 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 479431006599 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431006600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431006601 active site 479431006602 phosphorylation site [posttranslational modification] 479431006603 intermolecular recognition site; other site 479431006604 dimerization interface [polypeptide binding]; other site 479431006605 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431006606 DNA binding site [nucleotide binding] 479431006607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479431006608 dimerization interface [polypeptide binding]; other site 479431006609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431006610 dimer interface [polypeptide binding]; other site 479431006611 phosphorylation site [posttranslational modification] 479431006612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431006613 ATP binding site [chemical binding]; other site 479431006614 G-X-G motif; other site 479431006615 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 479431006616 MarR family; Region: MarR_2; pfam12802 479431006617 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431006618 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 479431006619 diiron binding motif [ion binding]; other site 479431006620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431006621 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 479431006622 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431006623 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479431006624 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 479431006625 active site residue [active] 479431006626 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 479431006627 CPxP motif; other site 479431006628 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 479431006629 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431006630 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 479431006631 active site 479431006632 HIGH motif; other site 479431006633 nucleotide binding site [chemical binding]; other site 479431006634 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431006635 active site 479431006636 KMSKS motif; other site 479431006637 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 479431006638 putative homotetramer interface [polypeptide binding]; other site 479431006639 putative homodimer interface [polypeptide binding]; other site 479431006640 putative allosteric switch controlling residues; other site 479431006641 putative metal binding site [ion binding]; other site 479431006642 putative homodimer-homodimer interface [polypeptide binding]; other site 479431006643 Domain of unknown function DUF302; Region: DUF302; cl01364 479431006644 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479431006645 catalytic residues [active] 479431006646 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 479431006647 active site residue [active] 479431006648 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479431006649 Rhodanese-like domain; Region: Rhodanese; pfam00581 479431006650 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 479431006651 active site residue [active] 479431006652 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479431006653 Integrase core domain; Region: rve; pfam00665 479431006654 Integrase core domain; Region: rve_3; pfam13683 479431006655 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479431006656 Cupin domain; Region: Cupin_2; pfam07883 479431006657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431006658 Transposase; Region: HTH_Tnp_1; cl17663 479431006659 PRC-barrel domain; Region: PRC; pfam05239 479431006660 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479431006661 hypothetical protein; Provisional; Region: PRK07588 479431006662 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 479431006663 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 479431006664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431006665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431006666 Domain of unknown function (DUF385); Region: DUF385; cl04387 479431006667 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 479431006668 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479431006669 homodimer interface [polypeptide binding]; other site 479431006670 active site 479431006671 TDP-binding site; other site 479431006672 acceptor substrate-binding pocket; other site 479431006673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431006674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431006675 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 479431006676 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 479431006677 Transposase [DNA replication, recombination, and repair]; Region: COG5421 479431006678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431006679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431006680 Cytochrome P450; Region: p450; pfam00067 479431006681 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479431006682 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 479431006683 Flavodoxin; Region: Flavodoxin_1; pfam00258 479431006684 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 479431006685 FAD binding pocket [chemical binding]; other site 479431006686 conserved FAD binding motif [chemical binding]; other site 479431006687 phosphate binding motif [ion binding]; other site 479431006688 beta-alpha-beta structure motif; other site 479431006689 NAD binding pocket [chemical binding]; other site 479431006690 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479431006691 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479431006692 active site 479431006693 catalytic residues [active] 479431006694 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479431006695 catalytic residues [active] 479431006696 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479431006697 Interdomain contacts; other site 479431006698 Cytokine receptor motif; other site 479431006699 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 479431006700 YHYH protein; Region: YHYH; pfam14240 479431006701 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479431006702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431006703 S-adenosylmethionine binding site [chemical binding]; other site 479431006704 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431006705 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431006706 DNA binding residues [nucleotide binding] 479431006707 dimerization interface [polypeptide binding]; other site 479431006708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431006709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431006710 intermolecular recognition site; other site 479431006711 active site 479431006712 dimerization interface [polypeptide binding]; other site 479431006713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431006714 DNA binding residues [nucleotide binding] 479431006715 dimerization interface [polypeptide binding]; other site 479431006716 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 479431006717 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479431006718 Cytochrome P450; Region: p450; pfam00067 479431006719 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 479431006720 Flavodoxin; Region: Flavodoxin_1; pfam00258 479431006721 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 479431006722 FAD binding pocket [chemical binding]; other site 479431006723 FAD binding motif [chemical binding]; other site 479431006724 catalytic residues [active] 479431006725 NAD binding pocket [chemical binding]; other site 479431006726 phosphate binding motif [ion binding]; other site 479431006727 beta-alpha-beta structure motif; other site 479431006728 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 479431006729 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 479431006730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431006731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431006732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431006733 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431006734 Walker A/P-loop; other site 479431006735 ATP binding site [chemical binding]; other site 479431006736 Q-loop/lid; other site 479431006737 ABC transporter signature motif; other site 479431006738 Walker B; other site 479431006739 D-loop; other site 479431006740 H-loop/switch region; other site 479431006741 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 479431006742 Domain of unknown function (DUF385); Region: DUF385; cl04387 479431006743 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 479431006744 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431006745 Uncharacterized conserved protein [Function unknown]; Region: COG5361 479431006746 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 479431006747 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 479431006748 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431006749 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 479431006750 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479431006751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479431006752 Predicted membrane protein [Function unknown]; Region: COG4325 479431006753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431006754 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 479431006755 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431006756 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 479431006757 putative NAD(P) binding site [chemical binding]; other site 479431006758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431006759 Histidine kinase; Region: HisKA_3; pfam07730 479431006760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431006761 ATP binding site [chemical binding]; other site 479431006762 Mg2+ binding site [ion binding]; other site 479431006763 G-X-G motif; other site 479431006764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431006765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431006766 active site 479431006767 phosphorylation site [posttranslational modification] 479431006768 intermolecular recognition site; other site 479431006769 dimerization interface [polypeptide binding]; other site 479431006770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431006771 DNA binding residues [nucleotide binding] 479431006772 dimerization interface [polypeptide binding]; other site 479431006773 SnoaL-like domain; Region: SnoaL_2; pfam12680 479431006774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431006775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431006776 active site 479431006777 phosphorylation site [posttranslational modification] 479431006778 intermolecular recognition site; other site 479431006779 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431006780 Histidine kinase; Region: HisKA_3; pfam07730 479431006781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431006782 ATP binding site [chemical binding]; other site 479431006783 Mg2+ binding site [ion binding]; other site 479431006784 G-X-G motif; other site 479431006785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431006786 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 479431006787 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479431006788 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431006789 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 479431006790 Walker A/P-loop; other site 479431006791 ATP binding site [chemical binding]; other site 479431006792 Q-loop/lid; other site 479431006793 ABC transporter signature motif; other site 479431006794 Walker B; other site 479431006795 D-loop; other site 479431006796 H-loop/switch region; other site 479431006797 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 479431006798 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431006799 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431006800 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 479431006801 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 479431006802 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479431006803 TrkA-C domain; Region: TrkA_C; pfam02080 479431006804 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 479431006805 Transposase [DNA replication, recombination, and repair]; Region: COG5421 479431006806 Recombinase; Region: Recombinase; pfam07508 479431006807 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 479431006808 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 479431006809 active site 479431006810 catalytic triad [active] 479431006811 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479431006812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431006813 Walker A motif; other site 479431006814 ATP binding site [chemical binding]; other site 479431006815 Walker B motif; other site 479431006816 arginine finger; other site 479431006817 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 479431006818 Recombinase; Region: Recombinase; pfam07508 479431006819 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479431006820 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479431006821 DNA binding residues [nucleotide binding] 479431006822 dimer interface [polypeptide binding]; other site 479431006823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431006824 ATP binding site [chemical binding]; other site 479431006825 Mg2+ binding site [ion binding]; other site 479431006826 G-X-G motif; other site 479431006827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431006828 Walker A motif; other site 479431006829 ATP binding site [chemical binding]; other site 479431006830 Walker B motif; other site 479431006831 arginine finger; other site 479431006832 Lsr2; Region: Lsr2; pfam11774 479431006833 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 479431006834 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 479431006835 metal ion-dependent adhesion site (MIDAS); other site 479431006836 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479431006837 AAA domain; Region: AAA_30; pfam13604 479431006838 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 479431006839 AAA domain; Region: AAA_12; pfam13087 479431006840 KTSC domain; Region: KTSC; pfam13619 479431006841 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12690 479431006842 AIPR protein; Region: AIPR; pfam10592 479431006843 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479431006844 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 479431006845 YfbU domain; Region: YfbU; cl01137 479431006846 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479431006847 Nuclease-related domain; Region: NERD; pfam08378 479431006848 Protein of unknown function (DUF575); Region: DUF575; pfam04746 479431006849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431006850 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431006851 salt bridge; other site 479431006852 non-specific DNA binding site [nucleotide binding]; other site 479431006853 sequence-specific DNA binding site [nucleotide binding]; other site 479431006854 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 479431006855 AAA-like domain; Region: AAA_10; pfam12846 479431006856 AAA domain; Region: AAA_31; pfam13614 479431006857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479431006858 Uncharacterized conserved protein [Function unknown]; Region: COG4933 479431006859 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 479431006860 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 479431006861 HSP70 interaction site [polypeptide binding]; other site 479431006862 AAA-like domain; Region: AAA_10; pfam12846 479431006863 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 479431006864 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 479431006865 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479431006866 helicase superfamily c-terminal domain; Region: HELICc; smart00490 479431006867 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 479431006868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431006869 S-adenosylmethionine binding site [chemical binding]; other site 479431006870 Transcription factor WhiB; Region: Whib; pfam02467 479431006871 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 479431006872 ADP-ribose binding site [chemical binding]; other site 479431006873 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 479431006874 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 479431006875 NlpC/P60 family; Region: NLPC_P60; cl17555 479431006876 HNH endonuclease; Region: HNH; pfam01844 479431006877 active site 479431006878 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 479431006879 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 479431006880 dimer interface [polypeptide binding]; other site 479431006881 ssDNA binding site [nucleotide binding]; other site 479431006882 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479431006883 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 479431006884 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 479431006885 active site 479431006886 PHP Thumb interface [polypeptide binding]; other site 479431006887 metal binding site [ion binding]; metal-binding site 479431006888 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431006889 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431006890 active site 479431006891 DNA binding site [nucleotide binding] 479431006892 Int/Topo IB signature motif; other site 479431006893 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479431006894 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431006895 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479431006896 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479431006897 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 479431006898 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479431006899 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 479431006900 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 479431006901 ATP binding site [chemical binding]; other site 479431006902 Walker A motif; other site 479431006903 hexamer interface [polypeptide binding]; other site 479431006904 Walker B motif; other site 479431006905 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 479431006906 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431006907 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 479431006908 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431006909 active site 479431006910 DNA binding site [nucleotide binding] 479431006911 Int/Topo IB signature motif; other site 479431006912 hypothetical protein; Provisional; Region: PRK07906 479431006913 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 479431006914 putative metal binding site [ion binding]; other site 479431006915 AzlC protein; Region: AzlC; pfam03591 479431006916 AAA domain; Region: AAA_30; pfam13604 479431006917 Family description; Region: UvrD_C_2; pfam13538 479431006918 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479431006919 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479431006920 active site 479431006921 catalytic tetrad [active] 479431006922 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431006923 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 479431006924 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 479431006925 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431006926 catalytic core [active] 479431006927 conserved hypothetical protein; Region: TIGR03847 479431006928 conserved hypothetical protein; Region: TIGR03843 479431006929 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 479431006930 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 479431006931 active site 479431006932 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 479431006933 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 479431006934 active site 479431006935 HIGH motif; other site 479431006936 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431006937 active site 479431006938 KMSKS motif; other site 479431006939 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 479431006940 MarR family; Region: MarR_2; pfam12802 479431006941 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479431006942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479431006943 nucleotide binding site [chemical binding]; other site 479431006944 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479431006945 Transcription factor WhiB; Region: Whib; pfam02467 479431006946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431006947 Walker A motif; other site 479431006948 ATP binding site [chemical binding]; other site 479431006949 PAC2 family; Region: PAC2; pfam09754 479431006950 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 479431006951 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 479431006952 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 479431006953 substrate binding pocket [chemical binding]; other site 479431006954 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 479431006955 B12 binding site [chemical binding]; other site 479431006956 cobalt ligand [ion binding]; other site 479431006957 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 479431006958 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 479431006959 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 479431006960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431006961 motif II; other site 479431006962 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 479431006963 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 479431006964 Protein of unknown function (DUF328); Region: DUF328; cl01143 479431006965 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 479431006966 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 479431006967 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 479431006968 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 479431006969 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 479431006970 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 479431006971 catalytic site [active] 479431006972 active site 479431006973 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 479431006974 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 479431006975 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 479431006976 active site 479431006977 catalytic site [active] 479431006978 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 479431006979 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 479431006980 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 479431006981 active site 479431006982 catalytic site [active] 479431006983 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 479431006984 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 479431006985 GIY-YIG motif/motif A; other site 479431006986 active site 479431006987 catalytic site [active] 479431006988 putative DNA binding site [nucleotide binding]; other site 479431006989 metal binding site [ion binding]; metal-binding site 479431006990 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 479431006991 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 479431006992 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 479431006993 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 479431006994 phosphate binding site [ion binding]; other site 479431006995 putative substrate binding pocket [chemical binding]; other site 479431006996 dimer interface [polypeptide binding]; other site 479431006997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 479431006998 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 479431006999 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 479431007000 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 479431007001 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 479431007002 Phosphoglycerate kinase; Region: PGK; pfam00162 479431007003 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 479431007004 substrate binding site [chemical binding]; other site 479431007005 hinge regions; other site 479431007006 ADP binding site [chemical binding]; other site 479431007007 catalytic site [active] 479431007008 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 479431007009 triosephosphate isomerase; Provisional; Region: PRK14567 479431007010 substrate binding site [chemical binding]; other site 479431007011 dimer interface [polypeptide binding]; other site 479431007012 catalytic triad [active] 479431007013 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 479431007014 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 479431007015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431007016 Coenzyme A binding pocket [chemical binding]; other site 479431007017 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 479431007018 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 479431007019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431007020 FeS/SAM binding site; other site 479431007021 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 479431007022 Competence-damaged protein; Region: CinA; pfam02464 479431007023 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431007024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431007025 non-specific DNA binding site [nucleotide binding]; other site 479431007026 salt bridge; other site 479431007027 sequence-specific DNA binding site [nucleotide binding]; other site 479431007028 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479431007029 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 479431007030 NADP+ binding site [chemical binding]; other site 479431007031 folate binding site [chemical binding]; other site 479431007032 ACT domain; Region: ACT_3; pfam10000 479431007033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 479431007034 thymidylate synthase; Reviewed; Region: thyA; PRK01827 479431007035 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 479431007036 dimerization interface [polypeptide binding]; other site 479431007037 active site 479431007038 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479431007039 putative active site [active] 479431007040 putative metal binding site [ion binding]; other site 479431007041 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479431007042 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 479431007043 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 479431007044 active site 479431007045 Isochorismatase family; Region: Isochorismatase; pfam00857 479431007046 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 479431007047 catalytic triad [active] 479431007048 conserved cis-peptide bond; other site 479431007049 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 479431007050 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 479431007051 H+ Antiporter protein; Region: 2A0121; TIGR00900 479431007052 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 479431007053 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431007054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431007055 non-specific DNA binding site [nucleotide binding]; other site 479431007056 salt bridge; other site 479431007057 sequence-specific DNA binding site [nucleotide binding]; other site 479431007058 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431007059 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 479431007060 putative NAD(P) binding site [chemical binding]; other site 479431007061 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 479431007062 Peptidase family M28; Region: Peptidase_M28; pfam04389 479431007063 metal binding site [ion binding]; metal-binding site 479431007064 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431007065 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 479431007066 Amidohydrolase; Region: Amidohydro_4; pfam13147 479431007067 active site 479431007068 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431007069 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 479431007070 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 479431007071 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 479431007072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431007073 catalytic residue [active] 479431007074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431007075 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 479431007076 dimer interface [polypeptide binding]; other site 479431007077 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 479431007078 active site 479431007079 metal binding site [ion binding]; metal-binding site 479431007080 homotetramer interface [polypeptide binding]; other site 479431007081 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479431007082 Peptidase family M23; Region: Peptidase_M23; pfam01551 479431007083 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479431007084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431007085 S-adenosylmethionine binding site [chemical binding]; other site 479431007086 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431007087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431007088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431007089 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431007090 putative acetyltransferase; Provisional; Region: PRK03624 479431007091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431007092 Coenzyme A binding pocket [chemical binding]; other site 479431007093 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 479431007094 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479431007095 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479431007096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431007097 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 479431007098 active site 479431007099 motif I; other site 479431007100 motif II; other site 479431007101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431007102 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479431007103 hydrophobic ligand binding site; other site 479431007104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431007105 dimerization interface [polypeptide binding]; other site 479431007106 putative DNA binding site [nucleotide binding]; other site 479431007107 putative Zn2+ binding site [ion binding]; other site 479431007108 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479431007109 putative hydrophobic ligand binding site [chemical binding]; other site 479431007110 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 479431007111 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479431007112 Domain of unknown function (DUF222); Region: DUF222; pfam02720 479431007113 OsmC-like protein; Region: OsmC; pfam02566 479431007114 Predicted transcriptional regulators [Transcription]; Region: COG1733 479431007115 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479431007116 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 479431007117 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431007118 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431007119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431007120 non-specific DNA binding site [nucleotide binding]; other site 479431007121 salt bridge; other site 479431007122 sequence-specific DNA binding site [nucleotide binding]; other site 479431007123 Cupin domain; Region: Cupin_2; pfam07883 479431007124 hypothetical protein; Provisional; Region: PRK04233 479431007125 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 479431007126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431007127 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479431007128 nudix motif; other site 479431007129 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431007130 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 479431007131 Walker A/P-loop; other site 479431007132 ATP binding site [chemical binding]; other site 479431007133 Q-loop/lid; other site 479431007134 ABC transporter signature motif; other site 479431007135 Walker B; other site 479431007136 D-loop; other site 479431007137 H-loop/switch region; other site 479431007138 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431007139 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431007140 active site 479431007141 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431007142 MarR family; Region: MarR_2; pfam12802 479431007143 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431007144 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431007145 putative transposase OrfB; Reviewed; Region: PHA02517 479431007146 HTH-like domain; Region: HTH_21; pfam13276 479431007147 Integrase core domain; Region: rve; pfam00665 479431007148 Integrase core domain; Region: rve_3; cl15866 479431007149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431007150 Transposase; Region: HTH_Tnp_1; cl17663 479431007151 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 479431007152 putative active site [active] 479431007153 putative metal binding residues [ion binding]; other site 479431007154 signature motif; other site 479431007155 putative dimer interface [polypeptide binding]; other site 479431007156 putative phosphate binding site [ion binding]; other site 479431007157 AAA ATPase domain; Region: AAA_16; pfam13191 479431007158 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431007159 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431007160 DNA binding residues [nucleotide binding] 479431007161 dimerization interface [polypeptide binding]; other site 479431007162 Transposase domain (DUF772); Region: DUF772; pfam05598 479431007163 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431007164 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431007165 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431007166 MULE transposase domain; Region: MULE; pfam10551 479431007167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431007168 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431007169 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479431007170 active site 479431007171 YCII-related domain; Region: YCII; cl00999 479431007172 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 479431007173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431007174 Predicted oxidoreductase [General function prediction only]; Region: COG3573 479431007175 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 479431007176 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 479431007177 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 479431007178 shikimate binding site; other site 479431007179 NAD(P) binding site [chemical binding]; other site 479431007180 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 479431007181 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 479431007182 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 479431007183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431007184 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479431007185 dimerization interface [polypeptide binding]; other site 479431007186 substrate binding pocket [chemical binding]; other site 479431007187 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 479431007188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431007189 Walker A/P-loop; other site 479431007190 ATP binding site [chemical binding]; other site 479431007191 Q-loop/lid; other site 479431007192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431007193 ABC transporter signature motif; other site 479431007194 Walker B; other site 479431007195 D-loop; other site 479431007196 H-loop/switch region; other site 479431007197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431007198 Walker A/P-loop; other site 479431007199 ATP binding site [chemical binding]; other site 479431007200 Q-loop/lid; other site 479431007201 ABC transporter signature motif; other site 479431007202 Walker B; other site 479431007203 D-loop; other site 479431007204 H-loop/switch region; other site 479431007205 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479431007206 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431007207 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479431007208 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479431007209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479431007210 Part of AAA domain; Region: AAA_19; pfam13245 479431007211 Family description; Region: UvrD_C_2; pfam13538 479431007212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431007213 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 479431007214 Walker A/P-loop; other site 479431007215 ATP binding site [chemical binding]; other site 479431007216 Q-loop/lid; other site 479431007217 ABC transporter signature motif; other site 479431007218 Walker B; other site 479431007219 D-loop; other site 479431007220 H-loop/switch region; other site 479431007221 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 479431007222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431007223 dimer interface [polypeptide binding]; other site 479431007224 conserved gate region; other site 479431007225 putative PBP binding loops; other site 479431007226 ABC-ATPase subunit interface; other site 479431007227 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 479431007228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 479431007229 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 479431007230 DNA binding residues [nucleotide binding] 479431007231 TOBE domain; Region: TOBE; cl01440 479431007232 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 479431007233 active site 479431007234 catalytic triad [active] 479431007235 FOG: WD40 repeat [General function prediction only]; Region: COG2319 479431007236 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 479431007237 structural tetrad; other site 479431007238 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 479431007239 structural tetrad; other site 479431007240 PQQ-like domain; Region: PQQ_2; pfam13360 479431007241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431007242 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431007243 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479431007244 DNA binding site [nucleotide binding] 479431007245 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479431007246 AAA ATPase domain; Region: AAA_16; pfam13191 479431007247 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431007248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431007249 DNA binding residues [nucleotide binding] 479431007250 dimerization interface [polypeptide binding]; other site 479431007251 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479431007252 homotrimer interaction site [polypeptide binding]; other site 479431007253 putative active site [active] 479431007254 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479431007255 FAD binding domain; Region: FAD_binding_4; pfam01565 479431007256 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479431007257 putative catalytic site [active] 479431007258 putative metal binding site [ion binding]; other site 479431007259 putative phosphate binding site [ion binding]; other site 479431007260 Domain of unknown function (DUF427); Region: DUF427; pfam04248 479431007261 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 479431007262 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479431007263 NAD(P) binding site [chemical binding]; other site 479431007264 catalytic residues [active] 479431007265 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 479431007266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479431007267 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479431007268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431007269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431007270 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 479431007271 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 479431007272 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 479431007273 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479431007274 putative active site [active] 479431007275 putative metal binding site [ion binding]; other site 479431007276 Putative sensor; Region: Sensor; pfam13796 479431007277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431007278 Histidine kinase; Region: HisKA_3; pfam07730 479431007279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431007280 ATP binding site [chemical binding]; other site 479431007281 Mg2+ binding site [ion binding]; other site 479431007282 G-X-G motif; other site 479431007283 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431007284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431007285 active site 479431007286 phosphorylation site [posttranslational modification] 479431007287 intermolecular recognition site; other site 479431007288 dimerization interface [polypeptide binding]; other site 479431007289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431007290 DNA binding residues [nucleotide binding] 479431007291 dimerization interface [polypeptide binding]; other site 479431007292 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 479431007293 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 479431007294 putative active site [active] 479431007295 catalytic site [active] 479431007296 putative metal binding site [ion binding]; other site 479431007297 thymidine kinase; Provisional; Region: PRK04296 479431007298 recA bacterial DNA recombination protein; Region: RecA; cl17211 479431007299 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 479431007300 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479431007301 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 479431007302 Ligand binding site; other site 479431007303 Putative Catalytic site; other site 479431007304 DXD motif; other site 479431007305 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 479431007306 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 479431007307 putative active site [active] 479431007308 catalytic triad [active] 479431007309 putative dimer interface [polypeptide binding]; other site 479431007310 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479431007311 FAD binding domain; Region: FAD_binding_4; pfam01565 479431007312 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 479431007313 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479431007314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431007315 DNA-binding site [nucleotide binding]; DNA binding site 479431007316 FCD domain; Region: FCD; pfam07729 479431007317 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 479431007318 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431007319 active site 479431007320 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479431007321 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 479431007322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431007323 motif II; other site 479431007324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431007325 putative substrate translocation pore; other site 479431007326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431007327 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 479431007328 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479431007329 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 479431007330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431007331 putative DNA binding site [nucleotide binding]; other site 479431007332 putative Zn2+ binding site [ion binding]; other site 479431007333 AsnC family; Region: AsnC_trans_reg; pfam01037 479431007334 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 479431007335 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 479431007336 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 479431007337 active site 479431007338 Dienelactone hydrolase family; Region: DLH; pfam01738 479431007339 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479431007340 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479431007341 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479431007342 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479431007343 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479431007344 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479431007345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431007346 DNA-binding site [nucleotide binding]; DNA binding site 479431007347 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 479431007348 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 479431007349 5'-3' exonuclease; Region: 53EXOc; smart00475 479431007350 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 479431007351 active site 479431007352 metal binding site 1 [ion binding]; metal-binding site 479431007353 putative 5' ssDNA interaction site; other site 479431007354 metal binding site 3; metal-binding site 479431007355 metal binding site 2 [ion binding]; metal-binding site 479431007356 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 479431007357 putative DNA binding site [nucleotide binding]; other site 479431007358 putative metal binding site [ion binding]; other site 479431007359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431007360 non-specific DNA binding site [nucleotide binding]; other site 479431007361 salt bridge; other site 479431007362 sequence-specific DNA binding site [nucleotide binding]; other site 479431007363 Cupin domain; Region: Cupin_2; pfam07883 479431007364 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 479431007365 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 479431007366 Na binding site [ion binding]; other site 479431007367 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 479431007368 agmatinase; Region: agmatinase; TIGR01230 479431007369 oligomer interface [polypeptide binding]; other site 479431007370 putative active site [active] 479431007371 Mn binding site [ion binding]; other site 479431007372 hypothetical protein; Provisional; Region: PRK07524 479431007373 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479431007374 PYR/PP interface [polypeptide binding]; other site 479431007375 dimer interface [polypeptide binding]; other site 479431007376 TPP binding site [chemical binding]; other site 479431007377 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479431007378 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 479431007379 TPP-binding site [chemical binding]; other site 479431007380 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 479431007381 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 479431007382 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431007383 ATP binding site [chemical binding]; other site 479431007384 putative Mg++ binding site [ion binding]; other site 479431007385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431007386 nucleotide binding region [chemical binding]; other site 479431007387 ATP-binding site [chemical binding]; other site 479431007388 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 479431007389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 479431007390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 479431007391 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 479431007392 Ion channel; Region: Ion_trans_2; pfam07885 479431007393 Predicted transcriptional regulator [Transcription]; Region: COG2378 479431007394 HTH domain; Region: HTH_11; cl17392 479431007395 WYL domain; Region: WYL; pfam13280 479431007396 Predicted transcriptional regulator [Transcription]; Region: COG2378 479431007397 WYL domain; Region: WYL; pfam13280 479431007398 WYL domain; Region: WYL; pfam13280 479431007399 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 479431007400 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 479431007401 Domain of unknown function DUF21; Region: DUF21; pfam01595 479431007402 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479431007403 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 479431007404 Domain of unknown function DUF21; Region: DUF21; pfam01595 479431007405 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479431007406 Transporter associated domain; Region: CorC_HlyC; pfam03471 479431007407 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 479431007408 CHAT domain; Region: CHAT; pfam12770 479431007409 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479431007410 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431007411 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 479431007412 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 479431007413 active site 479431007414 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 479431007415 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 479431007416 active site 479431007417 Pup-like protein; Region: Pup; pfam05639 479431007418 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 479431007419 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 479431007420 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431007421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431007422 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431007423 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479431007424 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479431007425 active site 479431007426 catalytic tetrad [active] 479431007427 proteasome ATPase; Region: pup_AAA; TIGR03689 479431007428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431007429 Walker A motif; other site 479431007430 ATP binding site [chemical binding]; other site 479431007431 Walker B motif; other site 479431007432 arginine finger; other site 479431007433 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 479431007434 active site 479431007435 putative substrate binding region [chemical binding]; other site 479431007436 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 479431007437 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 479431007438 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 479431007439 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 479431007440 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 479431007441 homodimer interface [polypeptide binding]; other site 479431007442 putative metal binding site [ion binding]; other site 479431007443 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 479431007444 active site 479431007445 catalytic site [active] 479431007446 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431007447 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431007448 DNA binding site [nucleotide binding] 479431007449 domain linker motif; other site 479431007450 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479431007451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431007452 dimerization interface [polypeptide binding]; other site 479431007453 putative DNA binding site [nucleotide binding]; other site 479431007454 putative Zn2+ binding site [ion binding]; other site 479431007455 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 479431007456 hydrogenase 4 subunit B; Validated; Region: PRK06521 479431007457 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479431007458 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 479431007459 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 479431007460 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479431007461 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 479431007462 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 479431007463 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 479431007464 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431007465 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 479431007466 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 479431007467 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 479431007468 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 479431007469 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 479431007470 putative oxidoreductase; Provisional; Region: PRK11579 479431007471 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431007472 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479431007473 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 479431007474 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479431007475 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 479431007476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431007477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431007478 tetracycline repressor protein TetR; Provisional; Region: PRK13756 479431007479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431007480 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479431007481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431007482 putative substrate translocation pore; other site 479431007483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431007484 putative substrate translocation pore; other site 479431007485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431007486 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479431007487 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431007488 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431007489 Walker A/P-loop; other site 479431007490 ATP binding site [chemical binding]; other site 479431007491 Q-loop/lid; other site 479431007492 ABC transporter signature motif; other site 479431007493 Walker B; other site 479431007494 D-loop; other site 479431007495 H-loop/switch region; other site 479431007496 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479431007497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431007498 Histidine kinase; Region: HisKA_3; pfam07730 479431007499 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431007500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431007501 active site 479431007502 phosphorylation site [posttranslational modification] 479431007503 intermolecular recognition site; other site 479431007504 dimerization interface [polypeptide binding]; other site 479431007505 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431007506 DNA binding residues [nucleotide binding] 479431007507 dimerization interface [polypeptide binding]; other site 479431007508 ChaB; Region: ChaB; pfam06150 479431007509 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 479431007510 active site 479431007511 metal binding site [ion binding]; metal-binding site 479431007512 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 479431007513 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 479431007514 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479431007515 active site 479431007516 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 479431007517 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 479431007518 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 479431007519 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479431007520 putative metal binding site [ion binding]; other site 479431007521 hypothetical protein; Provisional; Region: PRK14013 479431007522 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 479431007523 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479431007524 putative metal binding site [ion binding]; other site 479431007525 tellurite resistance protein terB; Region: terB; cd07176 479431007526 putative metal binding site [ion binding]; other site 479431007527 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 479431007528 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479431007529 putative metal binding site [ion binding]; other site 479431007530 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 479431007531 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479431007532 putative metal binding site [ion binding]; other site 479431007533 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 479431007534 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479431007535 putative metal binding site [ion binding]; other site 479431007536 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 479431007537 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479431007538 putative metal binding site [ion binding]; other site 479431007539 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 479431007540 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479431007541 putative metal binding site [ion binding]; other site 479431007542 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 479431007543 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 479431007544 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431007545 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 479431007546 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 479431007547 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431007548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431007549 Walker A/P-loop; other site 479431007550 ATP binding site [chemical binding]; other site 479431007551 Q-loop/lid; other site 479431007552 ABC transporter signature motif; other site 479431007553 Walker B; other site 479431007554 D-loop; other site 479431007555 H-loop/switch region; other site 479431007556 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431007557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431007558 active site 479431007559 phosphorylation site [posttranslational modification] 479431007560 intermolecular recognition site; other site 479431007561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431007562 DNA binding residues [nucleotide binding] 479431007563 dimerization interface [polypeptide binding]; other site 479431007564 excinuclease ABC subunit B; Provisional; Region: PRK05298 479431007565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431007566 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431007567 nucleotide binding region [chemical binding]; other site 479431007568 ATP-binding site [chemical binding]; other site 479431007569 Ultra-violet resistance protein B; Region: UvrB; pfam12344 479431007570 UvrB/uvrC motif; Region: UVR; pfam02151 479431007571 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 479431007572 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 479431007573 CoA-binding site [chemical binding]; other site 479431007574 ATP-binding [chemical binding]; other site 479431007575 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 479431007576 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 479431007577 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 479431007578 RNA binding site [nucleotide binding]; other site 479431007579 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 479431007580 RNA binding site [nucleotide binding]; other site 479431007581 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 479431007582 RNA binding site [nucleotide binding]; other site 479431007583 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 479431007584 RNA binding site [nucleotide binding]; other site 479431007585 domain interface; other site 479431007586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431007587 S-adenosylmethionine binding site [chemical binding]; other site 479431007588 Protein of unknown function (DUF805); Region: DUF805; pfam05656 479431007589 DNA polymerase I; Provisional; Region: PRK05755 479431007590 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 479431007591 active site 479431007592 metal binding site 1 [ion binding]; metal-binding site 479431007593 putative 5' ssDNA interaction site; other site 479431007594 metal binding site 3; metal-binding site 479431007595 metal binding site 2 [ion binding]; metal-binding site 479431007596 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 479431007597 putative DNA binding site [nucleotide binding]; other site 479431007598 putative metal binding site [ion binding]; other site 479431007599 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 479431007600 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 479431007601 active site 479431007602 DNA binding site [nucleotide binding] 479431007603 catalytic site [active] 479431007604 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 479431007605 CoenzymeA binding site [chemical binding]; other site 479431007606 subunit interaction site [polypeptide binding]; other site 479431007607 PHB binding site; other site 479431007608 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479431007609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431007610 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 479431007611 DNA-binding interface [nucleotide binding]; DNA binding site 479431007612 Integrase core domain; Region: rve; pfam00665 479431007613 Integrase core domain; Region: rve_3; cl15866 479431007614 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479431007615 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431007616 active site 479431007617 catalytic residues [active] 479431007618 DNA binding site [nucleotide binding] 479431007619 Int/Topo IB signature motif; other site 479431007620 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 479431007621 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431007622 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431007623 active site 479431007624 DNA binding site [nucleotide binding] 479431007625 Int/Topo IB signature motif; other site 479431007626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431007627 Integrase core domain; Region: rve; pfam00665 479431007628 transposase/IS protein; Provisional; Region: PRK09183 479431007629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431007630 Walker A motif; other site 479431007631 ATP binding site [chemical binding]; other site 479431007632 Walker B motif; other site 479431007633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431007634 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431007635 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 479431007636 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 479431007637 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 479431007638 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 479431007639 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 479431007640 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 479431007641 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 479431007642 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 479431007643 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 479431007644 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 479431007645 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 479431007646 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 479431007647 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 479431007648 Walker A/P-loop; other site 479431007649 ATP binding site [chemical binding]; other site 479431007650 Q-loop/lid; other site 479431007651 ABC transporter signature motif; other site 479431007652 Walker B; other site 479431007653 D-loop; other site 479431007654 H-loop/switch region; other site 479431007655 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 479431007656 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 479431007657 Walker A/P-loop; other site 479431007658 ATP binding site [chemical binding]; other site 479431007659 Q-loop/lid; other site 479431007660 ABC transporter signature motif; other site 479431007661 Walker B; other site 479431007662 D-loop; other site 479431007663 H-loop/switch region; other site 479431007664 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 479431007665 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 479431007666 TM-ABC transporter signature motif; other site 479431007667 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479431007668 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 479431007669 TM-ABC transporter signature motif; other site 479431007670 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 479431007671 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 479431007672 dimerization interface [polypeptide binding]; other site 479431007673 ligand binding site [chemical binding]; other site 479431007674 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 479431007675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431007676 active site 479431007677 phosphorylation site [posttranslational modification] 479431007678 intermolecular recognition site; other site 479431007679 dimerization interface [polypeptide binding]; other site 479431007680 ANTAR domain; Region: ANTAR; pfam03861 479431007681 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479431007682 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 479431007683 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 479431007684 putative dimer interface [polypeptide binding]; other site 479431007685 putative [2Fe-2S] cluster binding site [ion binding]; other site 479431007686 Cupin superfamily protein; Region: Cupin_4; pfam08007 479431007687 Cupin-like domain; Region: Cupin_8; pfam13621 479431007688 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 479431007689 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 479431007690 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 479431007691 active site 479431007692 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 479431007693 catalytic triad [active] 479431007694 dimer interface [polypeptide binding]; other site 479431007695 pyruvate kinase; Provisional; Region: PRK06247 479431007696 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 479431007697 domain interfaces; other site 479431007698 active site 479431007699 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 479431007700 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 479431007701 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 479431007702 active site 479431007703 dimer interface [polypeptide binding]; other site 479431007704 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 479431007705 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 479431007706 active site 479431007707 FMN binding site [chemical binding]; other site 479431007708 substrate binding site [chemical binding]; other site 479431007709 3Fe-4S cluster binding site [ion binding]; other site 479431007710 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 479431007711 domain interface; other site 479431007712 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 479431007713 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 479431007714 substrate binding site [chemical binding]; other site 479431007715 active site 479431007716 catalytic residues [active] 479431007717 heterodimer interface [polypeptide binding]; other site 479431007718 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 479431007719 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 479431007720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431007721 catalytic residue [active] 479431007722 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 479431007723 active site 479431007724 ribulose/triose binding site [chemical binding]; other site 479431007725 phosphate binding site [ion binding]; other site 479431007726 substrate (anthranilate) binding pocket [chemical binding]; other site 479431007727 product (indole) binding pocket [chemical binding]; other site 479431007728 anthranilate synthase component I; Provisional; Region: PRK13571 479431007729 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 479431007730 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 479431007731 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 479431007732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431007733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431007734 homodimer interface [polypeptide binding]; other site 479431007735 catalytic residue [active] 479431007736 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 479431007737 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 479431007738 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 479431007739 substrate binding site [chemical binding]; other site 479431007740 glutamase interaction surface [polypeptide binding]; other site 479431007741 Homeodomain-like domain; Region: HTH_23; cl17451 479431007742 Winged helix-turn helix; Region: HTH_29; pfam13551 479431007743 Integrase core domain; Region: rve; pfam00665 479431007744 Integrase core domain; Region: rve_3; pfam13683 479431007745 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 479431007746 homotrimer interaction site [polypeptide binding]; other site 479431007747 putative active site [active] 479431007748 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 479431007749 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 479431007750 catalytic residues [active] 479431007751 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 479431007752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431007753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431007754 Walker A/P-loop; other site 479431007755 Walker A/P-loop; other site 479431007756 ATP binding site [chemical binding]; other site 479431007757 ATP binding site [chemical binding]; other site 479431007758 Q-loop/lid; other site 479431007759 ABC transporter signature motif; other site 479431007760 Walker B; other site 479431007761 D-loop; other site 479431007762 H-loop/switch region; other site 479431007763 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 479431007764 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 479431007765 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 479431007766 active site 479431007767 catalytic site [active] 479431007768 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 479431007769 putative homodimer interface [polypeptide binding]; other site 479431007770 putative active site pocket [active] 479431007771 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 479431007772 trehalose synthase; Region: treS_nterm; TIGR02456 479431007773 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 479431007774 active site 479431007775 catalytic site [active] 479431007776 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 479431007777 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 479431007778 glycogen branching enzyme; Provisional; Region: PRK05402 479431007779 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 479431007780 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 479431007781 active site 479431007782 catalytic site [active] 479431007783 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 479431007784 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 479431007785 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 479431007786 putative active site [active] 479431007787 putative NTP binding site [chemical binding]; other site 479431007788 putative nucleic acid binding site [nucleotide binding]; other site 479431007789 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 479431007790 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479431007791 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 479431007792 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431007793 MarR family; Region: MarR; pfam01047 479431007794 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479431007795 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479431007796 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431007797 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431007798 Walker A/P-loop; other site 479431007799 ATP binding site [chemical binding]; other site 479431007800 Q-loop/lid; other site 479431007801 ABC transporter signature motif; other site 479431007802 Walker B; other site 479431007803 D-loop; other site 479431007804 H-loop/switch region; other site 479431007805 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479431007806 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 479431007807 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431007808 dimer interface [polypeptide binding]; other site 479431007809 substrate binding site [chemical binding]; other site 479431007810 metal binding site [ion binding]; metal-binding site 479431007811 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 479431007812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431007813 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 479431007814 Walker A/P-loop; other site 479431007815 ATP binding site [chemical binding]; other site 479431007816 Q-loop/lid; other site 479431007817 ABC transporter signature motif; other site 479431007818 Walker B; other site 479431007819 D-loop; other site 479431007820 H-loop/switch region; other site 479431007821 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431007822 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 479431007823 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 479431007824 ribosome recycling factor; Reviewed; Region: frr; PRK00083 479431007825 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 479431007826 hinge region; other site 479431007827 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 479431007828 putative nucleotide binding site [chemical binding]; other site 479431007829 uridine monophosphate binding site [chemical binding]; other site 479431007830 homohexameric interface [polypeptide binding]; other site 479431007831 elongation factor Ts; Provisional; Region: tsf; PRK09377 479431007832 UBA/TS-N domain; Region: UBA; pfam00627 479431007833 Elongation factor TS; Region: EF_TS; pfam00889 479431007834 Elongation factor TS; Region: EF_TS; pfam00889 479431007835 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 479431007836 rRNA interaction site [nucleotide binding]; other site 479431007837 S8 interaction site; other site 479431007838 putative laminin-1 binding site; other site 479431007839 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 479431007840 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431007841 active site 479431007842 DNA binding site [nucleotide binding] 479431007843 Int/Topo IB signature motif; other site 479431007844 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 479431007845 putative metal binding residues [ion binding]; other site 479431007846 signature motif; other site 479431007847 dimer interface [polypeptide binding]; other site 479431007848 active site 479431007849 polyP binding site; other site 479431007850 substrate binding site [chemical binding]; other site 479431007851 acceptor-phosphate pocket; other site 479431007852 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 479431007853 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479431007854 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479431007855 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479431007856 Magnesium ion binding site [ion binding]; other site 479431007857 DNA protecting protein DprA; Region: dprA; TIGR00732 479431007858 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 479431007859 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 479431007860 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 479431007861 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 479431007862 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 479431007863 hypothetical protein; Reviewed; Region: PRK12497 479431007864 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 479431007865 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 479431007866 active site 479431007867 catalytic triad [active] 479431007868 oxyanion hole [active] 479431007869 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431007870 Secretory lipase; Region: LIP; pfam03583 479431007871 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 479431007872 active site 479431007873 catalytic residues [active] 479431007874 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479431007875 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479431007876 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431007877 catalytic residue [active] 479431007878 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 479431007879 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 479431007880 RNA/DNA hybrid binding site [nucleotide binding]; other site 479431007881 active site 479431007882 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 479431007883 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 479431007884 Catalytic site [active] 479431007885 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 479431007886 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 479431007887 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 479431007888 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 479431007889 RimM N-terminal domain; Region: RimM; pfam01782 479431007890 PRC-barrel domain; Region: PRC; pfam05239 479431007891 hypothetical protein; Provisional; Region: PRK02821 479431007892 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 479431007893 G-X-X-G motif; other site 479431007894 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 479431007895 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 479431007896 FAD binding pocket [chemical binding]; other site 479431007897 FAD binding motif [chemical binding]; other site 479431007898 phosphate binding motif [ion binding]; other site 479431007899 NAD binding pocket [chemical binding]; other site 479431007900 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 479431007901 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479431007902 ABC-ATPase subunit interface; other site 479431007903 dimer interface [polypeptide binding]; other site 479431007904 putative PBP binding regions; other site 479431007905 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479431007906 dimer interface [polypeptide binding]; other site 479431007907 putative PBP binding regions; other site 479431007908 ABC-ATPase subunit interface; other site 479431007909 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479431007910 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479431007911 Walker A/P-loop; other site 479431007912 ATP binding site [chemical binding]; other site 479431007913 Q-loop/lid; other site 479431007914 ABC transporter signature motif; other site 479431007915 Walker B; other site 479431007916 D-loop; other site 479431007917 H-loop/switch region; other site 479431007918 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479431007919 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 479431007920 intersubunit interface [polypeptide binding]; other site 479431007921 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431007922 active site 479431007923 signal recognition particle protein; Provisional; Region: PRK10867 479431007924 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 479431007925 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 479431007926 P loop; other site 479431007927 GTP binding site [chemical binding]; other site 479431007928 Signal peptide binding domain; Region: SRP_SPB; pfam02978 479431007929 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431007930 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431007931 Walker A/P-loop; other site 479431007932 ATP binding site [chemical binding]; other site 479431007933 Q-loop/lid; other site 479431007934 ABC transporter signature motif; other site 479431007935 Walker B; other site 479431007936 D-loop; other site 479431007937 H-loop/switch region; other site 479431007938 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479431007939 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479431007940 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431007941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431007942 non-specific DNA binding site [nucleotide binding]; other site 479431007943 salt bridge; other site 479431007944 sequence-specific DNA binding site [nucleotide binding]; other site 479431007945 PII uridylyl-transferase; Provisional; Region: PRK03381 479431007946 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 479431007947 metal binding triad; other site 479431007948 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 479431007949 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 479431007950 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 479431007951 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 479431007952 Nitrogen regulatory protein P-II; Region: P-II; smart00938 479431007953 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 479431007954 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 479431007955 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 479431007956 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479431007957 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 479431007958 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 479431007959 metal binding triad; other site 479431007960 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 479431007961 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 479431007962 metal binding triad; other site 479431007963 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 479431007964 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 479431007965 catalytic triad [active] 479431007966 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 479431007967 putative catalytic site [active] 479431007968 putative phosphate binding site [ion binding]; other site 479431007969 active site 479431007970 metal binding site A [ion binding]; metal-binding site 479431007971 DNA binding site [nucleotide binding] 479431007972 putative AP binding site [nucleotide binding]; other site 479431007973 putative metal binding site B [ion binding]; other site 479431007974 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 479431007975 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 479431007976 active site 479431007977 PHP Thumb interface [polypeptide binding]; other site 479431007978 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 479431007979 generic binding surface II; other site 479431007980 generic binding surface I; other site 479431007981 DNA Polymerase Y-family; Region: PolY_like; cd03468 479431007982 active site 479431007983 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 479431007984 DNA binding site [nucleotide binding] 479431007985 Domain of unknown function (DUF222); Region: DUF222; pfam02720 479431007986 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479431007987 active site 479431007988 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 479431007989 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 479431007990 putative active site [active] 479431007991 oxyanion strand; other site 479431007992 catalytic triad [active] 479431007993 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 479431007994 putative active site pocket [active] 479431007995 4-fold oligomerization interface [polypeptide binding]; other site 479431007996 metal binding residues [ion binding]; metal-binding site 479431007997 3-fold/trimer interface [polypeptide binding]; other site 479431007998 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 479431007999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431008000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431008001 homodimer interface [polypeptide binding]; other site 479431008002 catalytic residue [active] 479431008003 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 479431008004 histidinol dehydrogenase; Region: hisD; TIGR00069 479431008005 NAD binding site [chemical binding]; other site 479431008006 dimerization interface [polypeptide binding]; other site 479431008007 product binding site; other site 479431008008 substrate binding site [chemical binding]; other site 479431008009 zinc binding site [ion binding]; other site 479431008010 catalytic residues [active] 479431008011 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 479431008012 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 479431008013 dimerization interface [polypeptide binding]; other site 479431008014 active site 479431008015 L-aspartate oxidase; Provisional; Region: PRK07804 479431008016 L-aspartate oxidase; Provisional; Region: PRK06175 479431008017 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 479431008018 quinolinate synthetase; Provisional; Region: PRK09375 479431008019 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 479431008020 nudix motif; other site 479431008021 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 479431008022 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 479431008023 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 479431008024 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 479431008025 active site 479431008026 PHP Thumb interface [polypeptide binding]; other site 479431008027 metal binding site [ion binding]; metal-binding site 479431008028 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 479431008029 generic binding surface II; other site 479431008030 generic binding surface I; other site 479431008031 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 479431008032 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 479431008033 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479431008034 active site 479431008035 catalytic site [active] 479431008036 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 479431008037 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 479431008038 active site 479431008039 dimer interface [polypeptide binding]; other site 479431008040 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 479431008041 dimer interface [polypeptide binding]; other site 479431008042 active site 479431008043 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431008044 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479431008045 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431008046 dimerization interface [polypeptide binding]; other site 479431008047 putative DNA binding site [nucleotide binding]; other site 479431008048 putative Zn2+ binding site [ion binding]; other site 479431008049 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 479431008050 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 479431008051 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 479431008052 active site 479431008053 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479431008054 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 479431008055 Ligand binding site; other site 479431008056 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 479431008057 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479431008058 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 479431008059 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 479431008060 substrate binding site; other site 479431008061 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 479431008062 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 479431008063 active site 479431008064 substrate binding site [chemical binding]; other site 479431008065 FMN binding site [chemical binding]; other site 479431008066 putative catalytic residues [active] 479431008067 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 479431008068 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 479431008069 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 479431008070 Probable Catalytic site; other site 479431008071 metal-binding site 479431008072 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 479431008073 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431008074 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 479431008075 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 479431008076 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 479431008077 extended (e) SDRs; Region: SDR_e; cd08946 479431008078 NAD(P) binding site [chemical binding]; other site 479431008079 active site 479431008080 substrate binding site [chemical binding]; other site 479431008081 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 479431008082 Bacterial sugar transferase; Region: Bac_transf; pfam02397 479431008083 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 479431008084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 479431008085 RNA binding surface [nucleotide binding]; other site 479431008086 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 479431008087 active site 479431008088 lipoprotein signal peptidase; Provisional; Region: PRK14764 479431008089 potassium/proton antiporter; Reviewed; Region: PRK05326 479431008090 TrkA-C domain; Region: TrkA_C; pfam02080 479431008091 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 479431008092 FAD binding site [chemical binding]; other site 479431008093 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 479431008094 substrate binding pocket [chemical binding]; other site 479431008095 substrate-Mg2+ binding site; other site 479431008096 aspartate-rich region 1; other site 479431008097 aspartate-rich region 2; other site 479431008098 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 479431008099 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 479431008100 putative active site [active] 479431008101 putative metal binding site [ion binding]; other site 479431008102 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 479431008103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431008104 Helix-turn-helix domain; Region: HTH_38; pfam13936 479431008105 Integrase core domain; Region: rve; pfam00665 479431008106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431008107 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479431008108 Walker A motif; other site 479431008109 ATP binding site [chemical binding]; other site 479431008110 Walker B motif; other site 479431008111 arginine finger; other site 479431008112 MarR family; Region: MarR_2; cl17246 479431008113 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479431008114 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479431008115 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 479431008116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431008117 FeS/SAM binding site; other site 479431008118 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 479431008119 Pyruvate formate lyase 1; Region: PFL1; cd01678 479431008120 coenzyme A binding site [chemical binding]; other site 479431008121 active site 479431008122 catalytic residues [active] 479431008123 glycine loop; other site 479431008124 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 479431008125 active site 479431008126 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 479431008127 aromatic chitin/cellulose binding site residues [chemical binding]; other site 479431008128 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 479431008129 aromatic chitin/cellulose binding site residues [chemical binding]; other site 479431008130 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479431008131 active site 479431008132 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 479431008133 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 479431008134 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 479431008135 putative catalytic cysteine [active] 479431008136 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 479431008137 putative active site [active] 479431008138 metal binding site [ion binding]; metal-binding site 479431008139 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431008140 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431008141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431008142 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 479431008143 active site 479431008144 motif I; other site 479431008145 motif II; other site 479431008146 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 479431008147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431008148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431008149 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479431008150 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479431008151 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 479431008152 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431008153 active site 479431008154 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431008155 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431008156 active site 479431008157 ATP binding site [chemical binding]; other site 479431008158 substrate binding site [chemical binding]; other site 479431008159 activation loop (A-loop); other site 479431008160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 479431008161 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431008162 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 479431008163 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431008164 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431008165 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431008166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479431008167 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479431008168 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 479431008169 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479431008170 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479431008171 putative acyl-acceptor binding pocket; other site 479431008172 Esterase/lipase [General function prediction only]; Region: COG1647 479431008173 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 479431008174 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479431008175 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479431008176 nucleotide binding site [chemical binding]; other site 479431008177 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 479431008178 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 479431008179 P loop; other site 479431008180 Nucleotide binding site [chemical binding]; other site 479431008181 DTAP/Switch II; other site 479431008182 Switch I; other site 479431008183 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 479431008184 putative hydrophobic ligand binding site [chemical binding]; other site 479431008185 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 479431008186 active site 479431008187 metal binding site [ion binding]; metal-binding site 479431008188 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 479431008189 NlpC/P60 family; Region: NLPC_P60; pfam00877 479431008190 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431008191 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479431008192 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 479431008193 NlpC/P60 family; Region: NLPC_P60; pfam00877 479431008194 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479431008195 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479431008196 DNA binding residues [nucleotide binding] 479431008197 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 479431008198 YacP-like NYN domain; Region: NYN_YacP; cl01491 479431008199 hypothetical protein; Validated; Region: PRK07883 479431008200 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 479431008201 active site 479431008202 catalytic site [active] 479431008203 substrate binding site [chemical binding]; other site 479431008204 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 479431008205 GIY-YIG motif/motif A; other site 479431008206 active site 479431008207 catalytic site [active] 479431008208 putative DNA binding site [nucleotide binding]; other site 479431008209 metal binding site [ion binding]; metal-binding site 479431008210 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479431008211 AsnC family; Region: AsnC_trans_reg; pfam01037 479431008212 FAD binding domain; Region: FAD_binding_4; pfam01565 479431008213 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 479431008214 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 479431008215 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 479431008216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 479431008217 active site 479431008218 phosphorylation site [posttranslational modification] 479431008219 intermolecular recognition site; other site 479431008220 dimerization interface [polypeptide binding]; other site 479431008221 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 479431008222 Subunit I/III interface [polypeptide binding]; other site 479431008223 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 479431008224 Cytochrome c; Region: Cytochrom_C; pfam00034 479431008225 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 479431008226 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 479431008227 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 479431008228 iron-sulfur cluster [ion binding]; other site 479431008229 [2Fe-2S] cluster binding site [ion binding]; other site 479431008230 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 479431008231 interchain domain interface [polypeptide binding]; other site 479431008232 heme bL binding site [chemical binding]; other site 479431008233 intrachain domain interface; other site 479431008234 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 479431008235 heme bH binding site [chemical binding]; other site 479431008236 Qo binding site; other site 479431008237 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479431008238 DNA binding residues [nucleotide binding] 479431008239 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479431008240 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479431008241 DNA binding residues [nucleotide binding] 479431008242 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 479431008243 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 479431008244 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 479431008245 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 479431008246 dimer interface [polypeptide binding]; other site 479431008247 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 479431008248 active site 479431008249 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 479431008250 Ligand Binding Site [chemical binding]; other site 479431008251 Molecular Tunnel; other site 479431008252 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 479431008253 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431008254 substrate binding site [chemical binding]; other site 479431008255 ATP binding site [chemical binding]; other site 479431008256 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 479431008257 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 479431008258 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 479431008259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431008260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431008261 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 479431008262 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 479431008263 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 479431008264 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431008265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 479431008266 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431008267 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431008268 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431008269 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479431008270 TAP-like protein; Region: Abhydrolase_4; pfam08386 479431008271 RNB domain; Region: RNB; pfam00773 479431008272 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 479431008273 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479431008274 active site 479431008275 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 479431008276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479431008277 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431008278 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 479431008279 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 479431008280 RNA/DNA hybrid binding site [nucleotide binding]; other site 479431008281 active site 479431008282 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431008283 catalytic core [active] 479431008284 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 479431008285 Putative zinc ribbon domain; Region: DUF164; pfam02591 479431008286 Uncharacterized conserved protein [Function unknown]; Region: COG0327 479431008287 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 479431008288 Low molecular weight phosphatase family; Region: LMWPc; cd00115 479431008289 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 479431008290 active site 479431008291 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 479431008292 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 479431008293 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 479431008294 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 479431008295 YndJ-like protein; Region: YndJ; pfam14158 479431008296 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479431008297 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431008298 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 479431008299 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431008300 MarR family; Region: MarR_2; pfam12802 479431008301 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 479431008302 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431008303 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431008304 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479431008305 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 479431008306 active site 479431008307 metal binding site [ion binding]; metal-binding site 479431008308 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 479431008309 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 479431008310 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 479431008311 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 479431008312 shikimate binding site; other site 479431008313 NAD(P) binding site [chemical binding]; other site 479431008314 YceG-like family; Region: YceG; pfam02618 479431008315 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 479431008316 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 479431008317 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 479431008318 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 479431008319 motif 1; other site 479431008320 active site 479431008321 motif 2; other site 479431008322 motif 3; other site 479431008323 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 479431008324 DHHA1 domain; Region: DHHA1; pfam02272 479431008325 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431008326 Ligand Binding Site [chemical binding]; other site 479431008327 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431008328 Ligand Binding Site [chemical binding]; other site 479431008329 hypothetical protein; Provisional; Region: PRK07907 479431008330 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 479431008331 active site 479431008332 metal binding site [ion binding]; metal-binding site 479431008333 dimer interface [polypeptide binding]; other site 479431008334 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 479431008335 active site 479431008336 catalytic site [active] 479431008337 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479431008338 active site 479431008339 catalytic residues [active] 479431008340 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 479431008341 active site 479431008342 substrate binding site [chemical binding]; other site 479431008343 trimer interface [polypeptide binding]; other site 479431008344 CoA binding site [chemical binding]; other site 479431008345 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 479431008346 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431008347 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 479431008348 NADP binding site [chemical binding]; other site 479431008349 dimer interface [polypeptide binding]; other site 479431008350 recombination factor protein RarA; Reviewed; Region: PRK13342 479431008351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431008352 Walker A motif; other site 479431008353 ATP binding site [chemical binding]; other site 479431008354 Walker B motif; other site 479431008355 arginine finger; other site 479431008356 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 479431008357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 479431008358 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 479431008359 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 479431008360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431008361 active site 479431008362 motif I; other site 479431008363 motif II; other site 479431008364 glycerol kinase; Provisional; Region: glpK; PRK00047 479431008365 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 479431008366 N- and C-terminal domain interface [polypeptide binding]; other site 479431008367 active site 479431008368 MgATP binding site [chemical binding]; other site 479431008369 catalytic site [active] 479431008370 metal binding site [ion binding]; metal-binding site 479431008371 glycerol binding site [chemical binding]; other site 479431008372 homotetramer interface [polypeptide binding]; other site 479431008373 homodimer interface [polypeptide binding]; other site 479431008374 FBP binding site [chemical binding]; other site 479431008375 protein IIAGlc interface [polypeptide binding]; other site 479431008376 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 479431008377 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 479431008378 substrate binding site [chemical binding]; other site 479431008379 dimer interface [polypeptide binding]; other site 479431008380 catalytic triad [active] 479431008381 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 479431008382 intersubunit interface [polypeptide binding]; other site 479431008383 active site 479431008384 zinc binding site [ion binding]; other site 479431008385 Na+ binding site [ion binding]; other site 479431008386 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 479431008387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431008388 motif II; other site 479431008389 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 479431008390 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479431008391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431008392 DNA-binding site [nucleotide binding]; DNA binding site 479431008393 UTRA domain; Region: UTRA; pfam07702 479431008394 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 479431008395 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479431008396 tetramer interface [polypeptide binding]; other site 479431008397 TPP-binding site [chemical binding]; other site 479431008398 heterodimer interface [polypeptide binding]; other site 479431008399 phosphorylation loop region [posttranslational modification] 479431008400 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479431008401 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 479431008402 PYR/PP interface [polypeptide binding]; other site 479431008403 dimer interface [polypeptide binding]; other site 479431008404 TPP binding site [chemical binding]; other site 479431008405 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479431008406 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 479431008407 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479431008408 E3 interaction surface; other site 479431008409 lipoyl attachment site [posttranslational modification]; other site 479431008410 e3 binding domain; Region: E3_binding; pfam02817 479431008411 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479431008412 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 479431008413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431008414 active site 479431008415 motif I; other site 479431008416 motif II; other site 479431008417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431008418 Iron-containing alcohol dehydrogenase; Region: Fe-ADH_2; pfam13685 479431008419 active site 479431008420 NAD binding site [chemical binding]; other site 479431008421 metal binding site [ion binding]; metal-binding site 479431008422 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479431008423 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 479431008424 nucleotide binding site [chemical binding]; other site 479431008425 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431008426 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 479431008427 putative NAD(P) binding site [chemical binding]; other site 479431008428 catalytic Zn binding site [ion binding]; other site 479431008429 structural Zn binding site [ion binding]; other site 479431008430 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 479431008431 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 479431008432 putative N- and C-terminal domain interface [polypeptide binding]; other site 479431008433 putative active site [active] 479431008434 MgATP binding site [chemical binding]; other site 479431008435 catalytic site [active] 479431008436 metal binding site [ion binding]; metal-binding site 479431008437 putative xylulose binding site [chemical binding]; other site 479431008438 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479431008439 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431008440 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431008441 Putative cyclase; Region: Cyclase; pfam04199 479431008442 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 479431008443 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 479431008444 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 479431008445 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 479431008446 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 479431008447 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 479431008448 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 479431008449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 479431008450 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 479431008451 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 479431008452 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 479431008453 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 479431008454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 479431008455 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 479431008456 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 479431008457 dimer interface [polypeptide binding]; other site 479431008458 anticodon binding site; other site 479431008459 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 479431008460 homodimer interface [polypeptide binding]; other site 479431008461 motif 1; other site 479431008462 active site 479431008463 motif 2; other site 479431008464 GAD domain; Region: GAD; pfam02938 479431008465 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479431008466 active site 479431008467 motif 3; other site 479431008468 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 479431008469 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431008470 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479431008471 YCII-related domain; Region: YCII; cl00999 479431008472 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479431008473 putative catalytic site [active] 479431008474 putative metal binding site [ion binding]; other site 479431008475 putative phosphate binding site [ion binding]; other site 479431008476 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 479431008477 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 479431008478 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 479431008479 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 479431008480 ATP binding site [chemical binding]; other site 479431008481 Mg++ binding site [ion binding]; other site 479431008482 motif III; other site 479431008483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431008484 nucleotide binding region [chemical binding]; other site 479431008485 ATP-binding site [chemical binding]; other site 479431008486 DbpA RNA binding domain; Region: DbpA; pfam03880 479431008487 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 479431008488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431008489 Radical SAM superfamily; Region: Radical_SAM; pfam04055 479431008490 FeS/SAM binding site; other site 479431008491 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 479431008492 active site 479431008493 catalytic triad [active] 479431008494 oxyanion hole [active] 479431008495 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 479431008496 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 479431008497 dimerization interface [polypeptide binding]; other site 479431008498 ligand binding site [chemical binding]; other site 479431008499 NADP binding site [chemical binding]; other site 479431008500 catalytic site [active] 479431008501 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 479431008502 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 479431008503 PYR/PP interface [polypeptide binding]; other site 479431008504 dimer interface [polypeptide binding]; other site 479431008505 TPP binding site [chemical binding]; other site 479431008506 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479431008507 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 479431008508 TPP-binding site [chemical binding]; other site 479431008509 dimer interface [polypeptide binding]; other site 479431008510 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479431008511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431008512 NAD(P) binding site [chemical binding]; other site 479431008513 active site 479431008514 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479431008515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431008516 DNA-binding site [nucleotide binding]; DNA binding site 479431008517 FCD domain; Region: FCD; pfam07729 479431008518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431008519 metabolite-proton symporter; Region: 2A0106; TIGR00883 479431008520 putative substrate translocation pore; other site 479431008521 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479431008522 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479431008523 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431008524 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479431008525 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431008526 DNA binding site [nucleotide binding] 479431008527 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 479431008528 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 479431008529 putative ligand binding site [chemical binding]; other site 479431008530 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 479431008531 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 479431008532 dimer interface [polypeptide binding]; other site 479431008533 motif 1; other site 479431008534 active site 479431008535 motif 2; other site 479431008536 motif 3; other site 479431008537 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 479431008538 anticodon binding site; other site 479431008539 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 479431008540 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 479431008541 active site 479431008542 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479431008543 Domain of unknown function (DUF222); Region: DUF222; pfam02720 479431008544 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479431008545 active site 479431008546 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 479431008547 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479431008548 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 479431008549 active site 479431008550 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479431008551 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 479431008552 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431008553 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 479431008554 putative ADP-binding pocket [chemical binding]; other site 479431008555 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479431008556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431008557 putative substrate translocation pore; other site 479431008558 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431008559 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479431008560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431008561 DNA-binding site [nucleotide binding]; DNA binding site 479431008562 FCD domain; Region: FCD; pfam07729 479431008563 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 479431008564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431008565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431008566 homodimer interface [polypeptide binding]; other site 479431008567 catalytic residue [active] 479431008568 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479431008569 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431008570 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431008571 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431008572 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 479431008573 putative ADP-binding pocket [chemical binding]; other site 479431008574 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479431008575 active site 479431008576 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 479431008577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431008578 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 479431008579 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479431008580 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 479431008581 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479431008582 Zn2+ binding site [ion binding]; other site 479431008583 Mg2+ binding site [ion binding]; other site 479431008584 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 479431008585 synthetase active site [active] 479431008586 NTP binding site [chemical binding]; other site 479431008587 metal binding site [ion binding]; metal-binding site 479431008588 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 479431008589 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 479431008590 Dodecin; Region: Dodecin; pfam07311 479431008591 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431008592 active site 479431008593 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 479431008594 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 479431008595 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 479431008596 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 479431008597 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479431008598 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431008599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431008600 Walker A/P-loop; other site 479431008601 ATP binding site [chemical binding]; other site 479431008602 Q-loop/lid; other site 479431008603 ABC transporter signature motif; other site 479431008604 Walker B; other site 479431008605 D-loop; other site 479431008606 H-loop/switch region; other site 479431008607 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431008608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431008609 active site 479431008610 phosphorylation site [posttranslational modification] 479431008611 intermolecular recognition site; other site 479431008612 dimerization interface [polypeptide binding]; other site 479431008613 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431008614 DNA binding residues [nucleotide binding] 479431008615 dimerization interface [polypeptide binding]; other site 479431008616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431008617 Histidine kinase; Region: HisKA_3; pfam07730 479431008618 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479431008619 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 479431008620 Protein export membrane protein; Region: SecD_SecF; pfam02355 479431008621 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 479431008622 Protein export membrane protein; Region: SecD_SecF; cl14618 479431008623 Preprotein translocase subunit; Region: YajC; pfam02699 479431008624 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 479431008625 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 479431008626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431008627 Walker A motif; other site 479431008628 ATP binding site [chemical binding]; other site 479431008629 Walker B motif; other site 479431008630 arginine finger; other site 479431008631 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 479431008632 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 479431008633 RuvA N terminal domain; Region: RuvA_N; pfam01330 479431008634 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 479431008635 active site 479431008636 putative DNA-binding cleft [nucleotide binding]; other site 479431008637 dimer interface [polypeptide binding]; other site 479431008638 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 479431008639 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 479431008640 heme-binding site [chemical binding]; other site 479431008641 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 479431008642 FAD binding pocket [chemical binding]; other site 479431008643 FAD binding motif [chemical binding]; other site 479431008644 phosphate binding motif [ion binding]; other site 479431008645 beta-alpha-beta structure motif; other site 479431008646 NAD binding pocket [chemical binding]; other site 479431008647 Heme binding pocket [chemical binding]; other site 479431008648 hypothetical protein; Validated; Region: PRK00110 479431008649 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 479431008650 predicted active site [active] 479431008651 catalytic triad [active] 479431008652 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 479431008653 Predicted membrane protein [Function unknown]; Region: COG2364 479431008654 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479431008655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431008656 DNA-binding site [nucleotide binding]; DNA binding site 479431008657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431008658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431008659 homodimer interface [polypeptide binding]; other site 479431008660 catalytic residue [active] 479431008661 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479431008662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431008663 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 479431008664 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 479431008665 active site 479431008666 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 479431008667 Predicted membrane protein [Function unknown]; Region: COG1971 479431008668 Domain of unknown function DUF; Region: DUF204; pfam02659 479431008669 Domain of unknown function DUF; Region: DUF204; pfam02659 479431008670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431008671 Histidine kinase; Region: HisKA_3; pfam07730 479431008672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431008673 ATP binding site [chemical binding]; other site 479431008674 Mg2+ binding site [ion binding]; other site 479431008675 G-X-G motif; other site 479431008676 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431008677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431008678 active site 479431008679 phosphorylation site [posttranslational modification] 479431008680 intermolecular recognition site; other site 479431008681 dimerization interface [polypeptide binding]; other site 479431008682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431008683 DNA binding residues [nucleotide binding] 479431008684 dimerization interface [polypeptide binding]; other site 479431008685 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431008686 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431008687 Walker A/P-loop; other site 479431008688 ATP binding site [chemical binding]; other site 479431008689 Q-loop/lid; other site 479431008690 ABC transporter signature motif; other site 479431008691 Walker B; other site 479431008692 D-loop; other site 479431008693 H-loop/switch region; other site 479431008694 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 479431008695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431008696 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431008697 DNA binding residues [nucleotide binding] 479431008698 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 479431008699 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 479431008700 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 479431008701 active site 479431008702 multimer interface [polypeptide binding]; other site 479431008703 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 479431008704 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479431008705 nudix motif; other site 479431008706 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431008707 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479431008708 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 479431008709 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 479431008710 putative acyl-acceptor binding pocket; other site 479431008711 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 479431008712 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479431008713 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431008714 active site 479431008715 ATP binding site [chemical binding]; other site 479431008716 substrate binding site [chemical binding]; other site 479431008717 activation loop (A-loop); other site 479431008718 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 479431008719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431008720 DNA binding residues [nucleotide binding] 479431008721 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 479431008722 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 479431008723 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 479431008724 putative N- and C-terminal domain interface [polypeptide binding]; other site 479431008725 putative active site [active] 479431008726 putative carbohydrate binding site [chemical binding]; other site 479431008727 MgATP binding site [chemical binding]; other site 479431008728 phosphoglycolate/pyridoxal phosphate phosphatase family; Region: PGP_euk; TIGR01452 479431008729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431008730 active site 479431008731 motif I; other site 479431008732 motif II; other site 479431008733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431008734 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 479431008735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 479431008736 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 479431008737 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479431008738 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431008739 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 479431008740 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 479431008741 ligand binding site [chemical binding]; other site 479431008742 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479431008743 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479431008744 TM-ABC transporter signature motif; other site 479431008745 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479431008746 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479431008747 Walker A/P-loop; other site 479431008748 ATP binding site [chemical binding]; other site 479431008749 Q-loop/lid; other site 479431008750 ABC transporter signature motif; other site 479431008751 Walker B; other site 479431008752 D-loop; other site 479431008753 H-loop/switch region; other site 479431008754 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 479431008755 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479431008756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479431008757 TM-ABC transporter signature motif; other site 479431008758 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 479431008759 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 479431008760 metal binding site [ion binding]; metal-binding site 479431008761 dimer interface [polypeptide binding]; other site 479431008762 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 479431008763 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479431008764 tetramer interface [polypeptide binding]; other site 479431008765 TPP-binding site [chemical binding]; other site 479431008766 heterodimer interface [polypeptide binding]; other site 479431008767 phosphorylation loop region [posttranslational modification] 479431008768 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479431008769 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 479431008770 alpha subunit interface [polypeptide binding]; other site 479431008771 TPP binding site [chemical binding]; other site 479431008772 heterodimer interface [polypeptide binding]; other site 479431008773 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479431008774 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479431008775 E3 interaction surface; other site 479431008776 lipoyl attachment site [posttranslational modification]; other site 479431008777 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 479431008778 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 479431008779 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479431008780 nucleotide binding site [chemical binding]; other site 479431008781 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 479431008782 intersubunit interface [polypeptide binding]; other site 479431008783 active site 479431008784 zinc binding site [ion binding]; other site 479431008785 Na+ binding site [ion binding]; other site 479431008786 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479431008787 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 479431008788 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 479431008789 nucleotide binding site/active site [active] 479431008790 HIT family signature motif; other site 479431008791 catalytic residue [active] 479431008792 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 479431008793 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 479431008794 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 479431008795 active site 479431008796 dimer interface [polypeptide binding]; other site 479431008797 motif 1; other site 479431008798 motif 2; other site 479431008799 motif 3; other site 479431008800 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 479431008801 anticodon binding site; other site 479431008802 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 479431008803 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 479431008804 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 479431008805 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 479431008806 Sulfate transporter family; Region: Sulfate_transp; pfam00916 479431008807 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 479431008808 Fructosamine kinase; Region: Fructosamin_kin; cl17579 479431008809 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 479431008810 hydrophobic ligand binding site; other site 479431008811 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 479431008812 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479431008813 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 479431008814 active site 479431008815 dimer interfaces [polypeptide binding]; other site 479431008816 catalytic residues [active] 479431008817 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 479431008818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431008819 NAD(P) binding site [chemical binding]; other site 479431008820 active site 479431008821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431008822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431008823 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479431008824 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 479431008825 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479431008826 DinB superfamily; Region: DinB_2; pfam12867 479431008827 methionine sulfoxide reductase A; Provisional; Region: PRK14054 479431008828 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 479431008829 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479431008830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431008831 motif II; other site 479431008832 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 479431008833 AAA ATPase domain; Region: AAA_16; pfam13191 479431008834 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431008835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431008836 DNA binding residues [nucleotide binding] 479431008837 dimerization interface [polypeptide binding]; other site 479431008838 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 479431008839 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431008840 tetramer interface [polypeptide binding]; other site 479431008841 catalytic Zn binding site [ion binding]; other site 479431008842 NADP binding site [chemical binding]; other site 479431008843 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 479431008844 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 479431008845 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431008846 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431008847 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431008848 MULE transposase domain; Region: MULE; pfam10551 479431008849 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479431008850 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431008851 active site 479431008852 catalytic residues [active] 479431008853 DNA binding site [nucleotide binding] 479431008854 Int/Topo IB signature motif; other site 479431008855 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 479431008856 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431008857 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431008858 active site 479431008859 DNA binding site [nucleotide binding] 479431008860 Int/Topo IB signature motif; other site 479431008861 transposase/IS protein; Provisional; Region: PRK09183 479431008862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431008863 Walker A motif; other site 479431008864 ATP binding site [chemical binding]; other site 479431008865 Walker B motif; other site 479431008866 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431008867 MULE transposase domain; Region: MULE; pfam10551 479431008868 Helix-turn-helix domain; Region: HTH_36; pfam13730 479431008869 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 479431008870 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 479431008871 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 479431008872 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479431008873 catalytic residue [active] 479431008874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431008875 putative transposase OrfB; Reviewed; Region: PHA02517 479431008876 HTH-like domain; Region: HTH_21; pfam13276 479431008877 Integrase core domain; Region: rve; pfam00665 479431008878 Integrase core domain; Region: rve_3; pfam13683 479431008879 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 479431008880 Integrase core domain; Region: rve; pfam00665 479431008881 Integrase core domain; Region: rve_3; pfam13683 479431008882 Helix-turn-helix domain; Region: HTH_17; cl17695 479431008883 AAA domain; Region: AAA_25; pfam13481 479431008884 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 479431008885 Walker A motif; other site 479431008886 ATP binding site [chemical binding]; other site 479431008887 Walker B motif; other site 479431008888 FaeA-like protein; Region: FaeA; pfam04703 479431008889 putative transposase OrfB; Reviewed; Region: PHA02517 479431008890 HTH-like domain; Region: HTH_21; pfam13276 479431008891 Integrase core domain; Region: rve; pfam00665 479431008892 Integrase core domain; Region: rve_3; cl15866 479431008893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431008894 Transposase; Region: HTH_Tnp_1; cl17663 479431008895 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431008896 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431008897 active site 479431008898 Int/Topo IB signature motif; other site 479431008899 DNA binding site [nucleotide binding] 479431008900 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 479431008901 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479431008902 RibD C-terminal domain; Region: RibD_C; cl17279 479431008903 Phosphate transporter family; Region: PHO4; pfam01384 479431008904 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 479431008905 active site 479431008906 metal binding site [ion binding]; metal-binding site 479431008907 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431008908 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431008909 DNA binding site [nucleotide binding] 479431008910 domain linker motif; other site 479431008911 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479431008912 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431008913 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431008914 DNA binding site [nucleotide binding] 479431008915 domain linker motif; other site 479431008916 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479431008917 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 479431008918 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 479431008919 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 479431008920 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 479431008921 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 479431008922 Ca binding site [ion binding]; other site 479431008923 active site 479431008924 catalytic site [active] 479431008925 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 479431008926 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 479431008927 putative dimer interface [polypeptide binding]; other site 479431008928 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 479431008929 Catalytic site [active] 479431008930 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 479431008931 Predicted membrane protein [Function unknown]; Region: COG4325 479431008932 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 479431008933 C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595 479431008934 gating phenylalanine in ion channel; other site 479431008935 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 479431008936 Bacterial sugar transferase; Region: Bac_transf; pfam02397 479431008937 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 479431008938 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 479431008939 O-Antigen ligase; Region: Wzy_C; pfam04932 479431008940 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 479431008941 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 479431008942 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431008943 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479431008944 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479431008945 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431008946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431008947 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479431008948 integral membrane protein; Region: integ_memb_HG; TIGR03954 479431008949 Glucitol operon activator protein (GutM); Region: GutM; cl01890 479431008950 Guanylyl transferase CofC like; Region: CofC; cl17472 479431008951 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 479431008952 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479431008953 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 479431008954 inhibitor-cofactor binding pocket; inhibition site 479431008955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431008956 catalytic residue [active] 479431008957 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 479431008958 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 479431008959 hypothetical protein; Provisional; Region: PRK14059 479431008960 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 479431008961 TAP-like protein; Region: Abhydrolase_4; pfam08386 479431008962 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 479431008963 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431008964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431008965 DNA binding residues [nucleotide binding] 479431008966 dimerization interface [polypeptide binding]; other site 479431008967 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479431008968 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 479431008969 dimer interface [polypeptide binding]; other site 479431008970 active site 479431008971 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479431008972 fatty oxidation complex, alpha subunit FadJ; Region: FadJ; TIGR02440 479431008973 substrate binding site [chemical binding]; other site 479431008974 oxyanion hole (OAH) forming residues; other site 479431008975 trimer interface [polypeptide binding]; other site 479431008976 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479431008977 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479431008978 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 479431008979 putative deacylase active site [active] 479431008980 DinB superfamily; Region: DinB_2; pfam12867 479431008981 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479431008982 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479431008983 homodimer interface [polypeptide binding]; other site 479431008984 active site 479431008985 TDP-binding site; other site 479431008986 acceptor substrate-binding pocket; other site 479431008987 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 479431008988 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 479431008989 putative active site [active] 479431008990 putative metal binding site [ion binding]; other site 479431008991 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 479431008992 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 479431008993 Helix-turn-helix domain; Region: HTH_38; pfam13936 479431008994 Integrase core domain; Region: rve; pfam00665 479431008995 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431008996 MULE transposase domain; Region: MULE; pfam10551 479431008997 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479431008998 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 479431008999 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 479431009000 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 479431009001 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 479431009002 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 479431009003 Cysteine-rich domain; Region: CCG; pfam02754 479431009004 Cysteine-rich domain; Region: CCG; pfam02754 479431009005 L-lactate permease; Region: Lactate_perm; cl00701 479431009006 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 479431009007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431009008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431009009 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479431009010 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479431009011 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479431009012 P-loop; other site 479431009013 Magnesium ion binding site [ion binding]; other site 479431009014 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479431009015 Magnesium ion binding site [ion binding]; other site 479431009016 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 479431009017 multiple promoter invertase; Provisional; Region: mpi; PRK13413 479431009018 catalytic residues [active] 479431009019 catalytic nucleophile [active] 479431009020 Presynaptic Site I dimer interface [polypeptide binding]; other site 479431009021 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 479431009022 Synaptic Flat tetramer interface [polypeptide binding]; other site 479431009023 Synaptic Site I dimer interface [polypeptide binding]; other site 479431009024 DNA binding site [nucleotide binding] 479431009025 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 479431009026 DNA-binding interface [nucleotide binding]; DNA binding site 479431009027 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 479431009028 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431009029 Walker A/P-loop; other site 479431009030 ATP binding site [chemical binding]; other site 479431009031 Q-loop/lid; other site 479431009032 ABC transporter signature motif; other site 479431009033 Walker B; other site 479431009034 D-loop; other site 479431009035 H-loop/switch region; other site 479431009036 Predicted transcriptional regulators [Transcription]; Region: COG1725 479431009037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431009038 DNA-binding site [nucleotide binding]; DNA binding site 479431009039 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 479431009040 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 479431009041 catalytic residues [active] 479431009042 catalytic nucleophile [active] 479431009043 Presynaptic Site I dimer interface [polypeptide binding]; other site 479431009044 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 479431009045 Synaptic Flat tetramer interface [polypeptide binding]; other site 479431009046 Synaptic Site I dimer interface [polypeptide binding]; other site 479431009047 DNA binding site [nucleotide binding] 479431009048 TniQ; Region: TniQ; pfam06527 479431009049 Bacterial TniB protein; Region: TniB; pfam05621 479431009050 AAA domain; Region: AAA_22; pfam13401 479431009051 Integrase core domain; Region: rve; pfam00665 479431009052 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 479431009053 Protein of unknown function (DUF2677); Region: DUF2677; pfam10838 479431009054 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 479431009055 Predicted flavoprotein [General function prediction only]; Region: COG0431 479431009056 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479431009057 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479431009058 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 479431009059 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479431009060 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 479431009061 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431009062 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431009063 thioredoxin 2; Provisional; Region: PRK10996 479431009064 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479431009065 catalytic residues [active] 479431009066 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 479431009067 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431009068 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431009069 active site 479431009070 DNA binding site [nucleotide binding] 479431009071 Int/Topo IB signature motif; other site 479431009072 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479431009073 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431009074 active site 479431009075 catalytic residues [active] 479431009076 DNA binding site [nucleotide binding] 479431009077 Int/Topo IB signature motif; other site 479431009078 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 479431009079 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 479431009080 chaperone protein DnaJ; Provisional; Region: PRK14299 479431009081 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 479431009082 HSP70 interaction site [polypeptide binding]; other site 479431009083 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 479431009084 substrate binding site [polypeptide binding]; other site 479431009085 dimer interface [polypeptide binding]; other site 479431009086 GrpE; Region: GrpE; pfam01025 479431009087 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 479431009088 dimer interface [polypeptide binding]; other site 479431009089 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 479431009090 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 479431009091 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 479431009092 nucleotide binding site [chemical binding]; other site 479431009093 NEF interaction site [polypeptide binding]; other site 479431009094 SBD interface [polypeptide binding]; other site 479431009095 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 479431009096 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431009097 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431009098 DNA binding residues [nucleotide binding] 479431009099 dimerization interface [polypeptide binding]; other site 479431009100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431009101 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431009102 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 479431009103 conserved cys residue [active] 479431009104 Integrase core domain; Region: rve; pfam00665 479431009105 Integrase core domain; Region: rve_3; pfam13683 479431009106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431009107 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 479431009108 DNA-binding interface [nucleotide binding]; DNA binding site 479431009109 Integrase core domain; Region: rve; pfam00665 479431009110 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 479431009111 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431009112 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431009113 active site 479431009114 DNA binding site [nucleotide binding] 479431009115 Int/Topo IB signature motif; other site 479431009116 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479431009117 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431009118 active site 479431009119 catalytic residues [active] 479431009120 DNA binding site [nucleotide binding] 479431009121 Int/Topo IB signature motif; other site 479431009122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431009123 putative transposase OrfB; Reviewed; Region: PHA02517 479431009124 HTH-like domain; Region: HTH_21; pfam13276 479431009125 Integrase core domain; Region: rve; pfam00665 479431009126 Integrase core domain; Region: rve_3; pfam13683 479431009127 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 479431009128 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 479431009129 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431009130 active site 479431009131 catalytic residues [active] 479431009132 DNA binding site [nucleotide binding] 479431009133 Int/Topo IB signature motif; other site 479431009134 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 479431009135 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431009136 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431009137 active site 479431009138 catalytic residues [active] 479431009139 DNA binding site [nucleotide binding] 479431009140 Int/Topo IB signature motif; other site 479431009141 potential frameshift: common BLAST hit: gi|111020189|ref|YP_703161.1| transposase B 479431009142 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 479431009143 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431009144 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431009145 active site 479431009146 catalytic residues [active] 479431009147 DNA binding site [nucleotide binding] 479431009148 Int/Topo IB signature motif; other site 479431009149 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479431009150 anti sigma factor interaction site; other site 479431009151 regulatory phosphorylation site [posttranslational modification]; other site 479431009152 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 479431009153 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 479431009154 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 479431009155 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 479431009156 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 479431009157 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 479431009158 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 479431009159 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 479431009160 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 479431009161 putative active site [active] 479431009162 putative substrate binding site [chemical binding]; other site 479431009163 putative cosubstrate binding site; other site 479431009164 catalytic site [active] 479431009165 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 479431009166 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 479431009167 Dodecin; Region: Dodecin; pfam07311 479431009168 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479431009169 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479431009170 Walker A/P-loop; other site 479431009171 ATP binding site [chemical binding]; other site 479431009172 Q-loop/lid; other site 479431009173 ABC transporter signature motif; other site 479431009174 Walker B; other site 479431009175 D-loop; other site 479431009176 H-loop/switch region; other site 479431009177 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479431009178 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431009179 MULE transposase domain; Region: MULE; pfam10551 479431009180 Integrase core domain; Region: rve; pfam00665 479431009181 Integrase core domain; Region: rve_3; pfam13683 479431009182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431009183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431009184 active site 479431009185 phosphorylation site [posttranslational modification] 479431009186 intermolecular recognition site; other site 479431009187 dimerization interface [polypeptide binding]; other site 479431009188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431009189 DNA binding residues [nucleotide binding] 479431009190 Predicted transcriptional regulator [Transcription]; Region: COG2345 479431009191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431009192 putative DNA binding site [nucleotide binding]; other site 479431009193 putative Zn2+ binding site [ion binding]; other site 479431009194 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431009195 MarR family; Region: MarR_2; pfam12802 479431009196 Cupin domain; Region: Cupin_2; cl17218 479431009197 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479431009198 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 479431009199 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 479431009200 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 479431009201 dimer interface [polypeptide binding]; other site 479431009202 aconitate hydratase; Validated; Region: PRK07229 479431009203 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 479431009204 substrate binding site [chemical binding]; other site 479431009205 ligand binding site [chemical binding]; other site 479431009206 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 479431009207 substrate binding site [chemical binding]; other site 479431009208 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 479431009209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431009210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431009211 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 479431009212 putative active site [active] 479431009213 transaldolase; Provisional; Region: PRK03903 479431009214 catalytic residue [active] 479431009215 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 479431009216 active site 479431009217 Helix-turn-helix domain; Region: HTH_20; pfam12840 479431009218 dimerization interface [polypeptide binding]; other site 479431009219 putative DNA binding site [nucleotide binding]; other site 479431009220 Predicted transcriptional regulator [Transcription]; Region: COG2345 479431009221 putative Zn2+ binding site [ion binding]; other site 479431009222 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479431009223 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431009224 Ligand Binding Site [chemical binding]; other site 479431009225 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 479431009226 dimer interface [polypeptide binding]; other site 479431009227 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 479431009228 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 479431009229 D-pathway; other site 479431009230 Putative ubiquinol binding site [chemical binding]; other site 479431009231 Low-spin heme (heme b) binding site [chemical binding]; other site 479431009232 Putative water exit pathway; other site 479431009233 Binuclear center (heme o3/CuB) [ion binding]; other site 479431009234 K-pathway; other site 479431009235 Putative proton exit pathway; other site 479431009236 Ferredoxin [Energy production and conversion]; Region: COG1146 479431009237 4Fe-4S binding domain; Region: Fer4; pfam00037 479431009238 Predicted transcriptional regulator [Transcription]; Region: COG2345 479431009239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 479431009240 Protein of unknown function, DUF488; Region: DUF488; cl01246 479431009241 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 479431009242 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 479431009243 heme-binding site [chemical binding]; other site 479431009244 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 479431009245 FAD binding pocket [chemical binding]; other site 479431009246 FAD binding motif [chemical binding]; other site 479431009247 phosphate binding motif [ion binding]; other site 479431009248 beta-alpha-beta structure motif; other site 479431009249 NAD binding pocket [chemical binding]; other site 479431009250 Heme binding pocket [chemical binding]; other site 479431009251 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 479431009252 multiple promoter invertase; Provisional; Region: mpi; PRK13413 479431009253 catalytic residues [active] 479431009254 catalytic nucleophile [active] 479431009255 Presynaptic Site I dimer interface [polypeptide binding]; other site 479431009256 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 479431009257 Synaptic Flat tetramer interface [polypeptide binding]; other site 479431009258 Synaptic Site I dimer interface [polypeptide binding]; other site 479431009259 DNA binding site [nucleotide binding] 479431009260 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 479431009261 DNA-binding interface [nucleotide binding]; DNA binding site 479431009262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431009263 transposase/IS protein; Provisional; Region: PRK09183 479431009264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431009265 Walker A motif; other site 479431009266 ATP binding site [chemical binding]; other site 479431009267 Walker B motif; other site 479431009268 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 479431009269 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 479431009270 putative dimer interface [polypeptide binding]; other site 479431009271 ANTAR domain; Region: ANTAR; pfam03861 479431009272 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 479431009273 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479431009274 DNA binding residues [nucleotide binding] 479431009275 putative dimer interface [polypeptide binding]; other site 479431009276 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 479431009277 putative transposase OrfB; Reviewed; Region: PHA02517 479431009278 HTH-like domain; Region: HTH_21; pfam13276 479431009279 Integrase core domain; Region: rve; pfam00665 479431009280 Integrase core domain; Region: rve_3; pfam13683 479431009281 Transposase; Region: HTH_Tnp_1; pfam01527 479431009282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431009283 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 479431009284 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 479431009285 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431009286 MULE transposase domain; Region: MULE; pfam10551 479431009287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431009288 transposase/IS protein; Provisional; Region: PRK09183 479431009289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431009290 Walker A motif; other site 479431009291 ATP binding site [chemical binding]; other site 479431009292 Walker B motif; other site 479431009293 Cation efflux family; Region: Cation_efflux; cl00316 479431009294 Hemerythrin-like domain; Region: Hr-like; cd12108 479431009295 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 479431009296 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 479431009297 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 479431009298 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 479431009299 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 479431009300 [4Fe-4S] binding site [ion binding]; other site 479431009301 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479431009302 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479431009303 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479431009304 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 479431009305 molybdopterin cofactor binding site; other site 479431009306 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 479431009307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431009308 putative substrate translocation pore; other site 479431009309 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 479431009310 HPP family; Region: HPP; pfam04982 479431009311 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 479431009312 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 479431009313 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479431009314 active site 479431009315 Uncharacterized protein conserved in archaea (DUF2180); Region: DUF2180; cl02017 479431009316 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 479431009317 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 479431009318 metal binding site [ion binding]; metal-binding site 479431009319 substrate binding pocket [chemical binding]; other site 479431009320 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 479431009321 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479431009322 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 479431009323 thiamine pyrophosphate protein; Provisional; Region: PRK08273 479431009324 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 479431009325 PYR/PP interface [polypeptide binding]; other site 479431009326 dimer interface [polypeptide binding]; other site 479431009327 tetramer interface [polypeptide binding]; other site 479431009328 TPP binding site [chemical binding]; other site 479431009329 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479431009330 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 479431009331 TPP-binding site [chemical binding]; other site 479431009332 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431009333 MarR family; Region: MarR; pfam01047 479431009334 short chain dehydrogenase; Provisional; Region: PRK07109 479431009335 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 479431009336 putative NAD(P) binding site [chemical binding]; other site 479431009337 active site 479431009338 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 479431009339 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 479431009340 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 479431009341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479431009342 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 479431009343 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 479431009344 active site 479431009345 homotetramer interface [polypeptide binding]; other site 479431009346 MarR family; Region: MarR; pfam01047 479431009347 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 479431009348 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431009349 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431009350 active site 479431009351 DNA binding site [nucleotide binding] 479431009352 Int/Topo IB signature motif; other site 479431009353 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479431009354 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431009355 active site 479431009356 catalytic residues [active] 479431009357 DNA binding site [nucleotide binding] 479431009358 Int/Topo IB signature motif; other site 479431009359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431009360 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 479431009361 DNA-binding interface [nucleotide binding]; DNA binding site 479431009362 Integrase core domain; Region: rve; pfam00665 479431009363 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 479431009364 gating phenylalanine in ion channel; other site 479431009365 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 479431009366 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431009367 active site 479431009368 DNA binding site [nucleotide binding] 479431009369 Int/Topo IB signature motif; other site 479431009370 AAA ATPase domain; Region: AAA_16; pfam13191 479431009371 Predicted ATPase [General function prediction only]; Region: COG3903 479431009372 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431009373 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431009374 DNA binding residues [nucleotide binding] 479431009375 dimerization interface [polypeptide binding]; other site 479431009376 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 479431009377 Integrase core domain; Region: rve; pfam00665 479431009378 Integrase core domain; Region: rve_3; pfam13683 479431009379 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479431009380 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431009381 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 479431009382 Walker A/P-loop; other site 479431009383 ATP binding site [chemical binding]; other site 479431009384 Q-loop/lid; other site 479431009385 ABC transporter signature motif; other site 479431009386 Walker B; other site 479431009387 D-loop; other site 479431009388 H-loop/switch region; other site 479431009389 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431009390 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 479431009391 putative NAD(P) binding site [chemical binding]; other site 479431009392 tetracycline repressor protein TetR; Provisional; Region: PRK13756 479431009393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431009394 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479431009395 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 479431009396 putative hydrophobic ligand binding site [chemical binding]; other site 479431009397 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 479431009398 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 479431009399 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431009400 active site 479431009401 Int/Topo IB signature motif; other site 479431009402 DNA binding site [nucleotide binding] 479431009403 Transposase; Region: HTH_Tnp_1; pfam01527 479431009404 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479431009405 FAD binding domain; Region: FAD_binding_4; pfam01565 479431009406 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 479431009407 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 479431009408 L-lactate permease; Region: Lactate_perm; cl00701 479431009409 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 479431009410 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 479431009411 Cysteine-rich domain; Region: CCG; pfam02754 479431009412 Cysteine-rich domain; Region: CCG; pfam02754 479431009413 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 479431009414 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 479431009415 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 479431009416 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 479431009417 Homeodomain-like domain; Region: HTH_23; cl17451 479431009418 Winged helix-turn helix; Region: HTH_29; pfam13551 479431009419 Integrase core domain; Region: rve; pfam00665 479431009420 Integrase core domain; Region: rve_3; pfam13683 479431009421 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431009422 MULE transposase domain; Region: MULE; pfam10551 479431009423 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 479431009424 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431009425 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431009426 active site 479431009427 DNA binding site [nucleotide binding] 479431009428 Int/Topo IB signature motif; other site 479431009429 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479431009430 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431009431 active site 479431009432 catalytic residues [active] 479431009433 DNA binding site [nucleotide binding] 479431009434 Int/Topo IB signature motif; other site 479431009435 AAA domain; Region: AAA_22; pfam13401 479431009436 AAA ATPase domain; Region: AAA_16; pfam13191 479431009437 Walker A motif; other site 479431009438 ATP binding site [chemical binding]; other site 479431009439 Walker B motif; other site 479431009440 arginine finger; other site 479431009441 Helix-turn-helix domain; Region: HTH_28; pfam13518 479431009442 Winged helix-turn helix; Region: HTH_29; pfam13551 479431009443 Homeodomain-like domain; Region: HTH_32; pfam13565 479431009444 Integrase core domain; Region: rve; pfam00665 479431009445 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 479431009446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431009447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431009448 dimer interface [polypeptide binding]; other site 479431009449 phosphorylation site [posttranslational modification] 479431009450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431009451 ATP binding site [chemical binding]; other site 479431009452 Mg2+ binding site [ion binding]; other site 479431009453 G-X-G motif; other site 479431009454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431009455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431009456 active site 479431009457 phosphorylation site [posttranslational modification] 479431009458 intermolecular recognition site; other site 479431009459 dimerization interface [polypeptide binding]; other site 479431009460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431009461 DNA binding site [nucleotide binding] 479431009462 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 479431009463 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 479431009464 TPP-binding site; other site 479431009465 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 479431009466 PYR/PP interface [polypeptide binding]; other site 479431009467 dimer interface [polypeptide binding]; other site 479431009468 TPP binding site [chemical binding]; other site 479431009469 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479431009470 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 479431009471 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 479431009472 active site 479431009473 catalytic site [active] 479431009474 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 479431009475 TRAM domain; Region: TRAM; pfam01938 479431009476 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 479431009477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431009478 S-adenosylmethionine binding site [chemical binding]; other site 479431009479 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 479431009480 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479431009481 TrkA-N domain; Region: TrkA_N; pfam02254 479431009482 TrkA-C domain; Region: TrkA_C; pfam02080 479431009483 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479431009484 TrkA-N domain; Region: TrkA_N; pfam02254 479431009485 TrkA-C domain; Region: TrkA_C; pfam02080 479431009486 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 479431009487 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 479431009488 ssDNA binding site; other site 479431009489 generic binding surface II; other site 479431009490 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 479431009491 metal binding site [ion binding]; metal-binding site 479431009492 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 479431009493 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 479431009494 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479431009495 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479431009496 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 479431009497 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 479431009498 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431009499 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479431009500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431009501 DNA binding residues [nucleotide binding] 479431009502 Peptidase family M48; Region: Peptidase_M48; cl12018 479431009503 Penicillinase repressor; Region: Pencillinase_R; pfam03965 479431009504 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 479431009505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431009506 Walker A/P-loop; other site 479431009507 ATP binding site [chemical binding]; other site 479431009508 Q-loop/lid; other site 479431009509 ABC transporter signature motif; other site 479431009510 Walker B; other site 479431009511 D-loop; other site 479431009512 H-loop/switch region; other site 479431009513 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 479431009514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431009515 Walker A/P-loop; other site 479431009516 ATP binding site [chemical binding]; other site 479431009517 Q-loop/lid; other site 479431009518 ABC transporter signature motif; other site 479431009519 Walker B; other site 479431009520 D-loop; other site 479431009521 H-loop/switch region; other site 479431009522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431009523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431009524 DNA binding residues [nucleotide binding] 479431009525 dimerization interface [polypeptide binding]; other site 479431009526 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 479431009527 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 479431009528 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 479431009529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 479431009530 ATP binding site [chemical binding]; other site 479431009531 putative Mg++ binding site [ion binding]; other site 479431009532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 479431009533 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 479431009534 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 479431009535 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 479431009536 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 479431009537 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431009538 substrate binding site [chemical binding]; other site 479431009539 ATP binding site [chemical binding]; other site 479431009540 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 479431009541 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479431009542 minor groove reading motif; other site 479431009543 helix-hairpin-helix signature motif; other site 479431009544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431009545 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 479431009546 S-adenosylmethionine binding site [chemical binding]; other site 479431009547 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 479431009548 putative active site [active] 479431009549 dimerization interface [polypeptide binding]; other site 479431009550 putative tRNAtyr binding site [nucleotide binding]; other site 479431009551 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 479431009552 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 479431009553 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431009554 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479431009555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431009556 DNA binding residues [nucleotide binding] 479431009557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431009558 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479431009559 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479431009560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431009561 Coenzyme A binding pocket [chemical binding]; other site 479431009562 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 479431009563 CoA binding domain; Region: CoA_binding_2; pfam13380 479431009564 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 479431009565 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 479431009566 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 479431009567 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 479431009568 active site 479431009569 Zn binding site [ion binding]; other site 479431009570 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 479431009571 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 479431009572 active site residue [active] 479431009573 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 479431009574 active site residue [active] 479431009575 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 479431009576 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 479431009577 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 479431009578 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 479431009579 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 479431009580 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 479431009581 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 479431009582 NAD-dependent deacetylase; Provisional; Region: PRK05333 479431009583 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 479431009584 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 479431009585 HIGH motif; other site 479431009586 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 479431009587 active site 479431009588 KMSKS motif; other site 479431009589 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 479431009590 tRNA binding surface [nucleotide binding]; other site 479431009591 anticodon binding site; other site 479431009592 DivIVA domain; Region: DivI1A_domain; TIGR03544 479431009593 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 479431009594 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 479431009595 YGGT family; Region: YGGT; cl00508 479431009596 Protein of unknown function (DUF552); Region: DUF552; cl00775 479431009597 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 479431009598 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 479431009599 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 479431009600 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 479431009601 nucleotide binding site [chemical binding]; other site 479431009602 SulA interaction site; other site 479431009603 Bacterial PH domain; Region: DUF304; cl01348 479431009604 Predicted membrane protein [Function unknown]; Region: COG3428 479431009605 Bacterial PH domain; Region: DUF304; pfam03703 479431009606 Bacterial PH domain; Region: DUF304; cl01348 479431009607 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 479431009608 elongation factor G; Reviewed; Region: PRK12740 479431009609 G1 box; other site 479431009610 GTP/Mg2+ binding site [chemical binding]; other site 479431009611 G2 box; other site 479431009612 Switch I region; other site 479431009613 G3 box; other site 479431009614 Switch II region; other site 479431009615 G4 box; other site 479431009616 G5 box; other site 479431009617 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 479431009618 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 479431009619 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 479431009620 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479431009621 FAD binding domain; Region: FAD_binding_4; pfam01565 479431009622 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 479431009623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431009624 S-adenosylmethionine binding site [chemical binding]; other site 479431009625 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 479431009626 active site 479431009627 Zn binding site [ion binding]; other site 479431009628 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 479431009629 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479431009630 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479431009631 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431009632 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479431009633 AAA ATPase domain; Region: AAA_16; pfam13191 479431009634 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479431009635 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431009636 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431009637 DNA binding residues [nucleotide binding] 479431009638 dimerization interface [polypeptide binding]; other site 479431009639 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 479431009640 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 479431009641 dimer interface [polypeptide binding]; other site 479431009642 active site 479431009643 heme binding site [chemical binding]; other site 479431009644 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 479431009645 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 479431009646 metal binding site 2 [ion binding]; metal-binding site 479431009647 putative DNA binding helix; other site 479431009648 metal binding site 1 [ion binding]; metal-binding site 479431009649 dimer interface [polypeptide binding]; other site 479431009650 structural Zn2+ binding site [ion binding]; other site 479431009651 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479431009652 homodimer interface [polypeptide binding]; other site 479431009653 glycosyltransferase, MGT family; Region: MGT; TIGR01426 479431009654 active site 479431009655 TDP-binding site; other site 479431009656 acceptor substrate-binding pocket; other site 479431009657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431009658 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431009659 putative substrate translocation pore; other site 479431009660 Chromate transporter; Region: Chromate_transp; pfam02417 479431009661 Chromate transporter; Region: Chromate_transp; pfam02417 479431009662 YCII-related domain; Region: YCII; cl00999 479431009663 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479431009664 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479431009665 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 479431009666 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479431009667 DinB superfamily; Region: DinB_2; pfam12867 479431009668 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479431009669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431009670 S-adenosylmethionine binding site [chemical binding]; other site 479431009671 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479431009672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431009673 Predicted transcriptional regulators [Transcription]; Region: COG1695 479431009674 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479431009675 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479431009676 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479431009677 Walker A/P-loop; other site 479431009678 ATP binding site [chemical binding]; other site 479431009679 Q-loop/lid; other site 479431009680 ABC transporter signature motif; other site 479431009681 Walker B; other site 479431009682 D-loop; other site 479431009683 H-loop/switch region; other site 479431009684 Domain of unknown function (DUF222); Region: DUF222; pfam02720 479431009685 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479431009686 active site 479431009687 FOG: CBS domain [General function prediction only]; Region: COG0517 479431009688 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 479431009689 Predicted transcriptional regulators [Transcription]; Region: COG1695 479431009690 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479431009691 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479431009692 DinB superfamily; Region: DinB_2; pfam12867 479431009693 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 479431009694 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 479431009695 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 479431009696 putative active site [active] 479431009697 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479431009698 active site 479431009699 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479431009700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431009701 NAD(P) binding site [chemical binding]; other site 479431009702 active site 479431009703 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 479431009704 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431009705 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431009706 DNA binding site [nucleotide binding] 479431009707 domain linker motif; other site 479431009708 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 479431009709 putative dimerization interface [polypeptide binding]; other site 479431009710 putative ligand binding site [chemical binding]; other site 479431009711 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479431009712 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479431009713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431009714 dimer interface [polypeptide binding]; other site 479431009715 conserved gate region; other site 479431009716 putative PBP binding loops; other site 479431009717 ABC-ATPase subunit interface; other site 479431009718 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479431009719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431009720 dimer interface [polypeptide binding]; other site 479431009721 conserved gate region; other site 479431009722 putative PBP binding loops; other site 479431009723 ABC-ATPase subunit interface; other site 479431009724 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 479431009725 active site 479431009726 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 479431009727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479431009728 benzoate transport; Region: 2A0115; TIGR00895 479431009729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431009730 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 479431009731 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 479431009732 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479431009733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431009734 motif II; other site 479431009735 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 479431009736 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 479431009737 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 479431009738 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 479431009739 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 479431009740 Domain of unknown function DUF21; Region: DUF21; pfam01595 479431009741 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479431009742 Domain of unknown function DUF21; Region: DUF21; pfam01595 479431009743 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 479431009744 FOG: CBS domain [General function prediction only]; Region: COG0517 479431009745 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479431009746 Transporter associated domain; Region: CorC_HlyC; pfam03471 479431009747 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431009748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431009749 active site 479431009750 phosphorylation site [posttranslational modification] 479431009751 intermolecular recognition site; other site 479431009752 dimerization interface [polypeptide binding]; other site 479431009753 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431009754 DNA binding residues [nucleotide binding] 479431009755 Thioesterase domain; Region: Thioesterase; pfam00975 479431009756 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431009757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431009758 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431009759 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 479431009760 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 479431009761 Putative sensor; Region: Sensor; pfam13796 479431009762 Histidine kinase; Region: HisKA_3; pfam07730 479431009763 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479431009764 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 479431009765 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 479431009766 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479431009767 H+ Antiporter protein; Region: 2A0121; TIGR00900 479431009768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 479431009769 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 479431009770 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 479431009771 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 479431009772 Condensation domain; Region: Condensation; pfam00668 479431009773 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479431009774 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479431009775 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479431009776 acyl-activating enzyme (AAE) consensus motif; other site 479431009777 AMP binding site [chemical binding]; other site 479431009778 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479431009779 Condensation domain; Region: Condensation; pfam00668 479431009780 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479431009781 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479431009782 acyl-activating enzyme (AAE) consensus motif; other site 479431009783 AMP binding site [chemical binding]; other site 479431009784 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479431009785 Condensation domain; Region: Condensation; pfam00668 479431009786 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479431009787 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479431009788 acyl-activating enzyme (AAE) consensus motif; other site 479431009789 AMP binding site [chemical binding]; other site 479431009790 Condensation domain; Region: Condensation; pfam00668 479431009791 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479431009792 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479431009793 acyl-activating enzyme (AAE) consensus motif; other site 479431009794 AMP binding site [chemical binding]; other site 479431009795 Condensation domain; Region: Condensation; pfam00668 479431009796 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479431009797 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479431009798 acyl-activating enzyme (AAE) consensus motif; other site 479431009799 AMP binding site [chemical binding]; other site 479431009800 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479431009801 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431009802 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431009803 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479431009804 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479431009805 acyl-activating enzyme (AAE) consensus motif; other site 479431009806 AMP binding site [chemical binding]; other site 479431009807 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479431009808 Condensation domain; Region: Condensation; pfam00668 479431009809 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479431009810 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479431009811 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479431009812 acyl-activating enzyme (AAE) consensus motif; other site 479431009813 AMP binding site [chemical binding]; other site 479431009814 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479431009815 MbtH-like protein; Region: MbtH; cl01279 479431009816 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 479431009817 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 479431009818 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 479431009819 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 479431009820 dimer interface [polypeptide binding]; other site 479431009821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431009822 catalytic residue [active] 479431009823 Condensation domain; Region: Condensation; pfam00668 479431009824 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479431009825 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479431009826 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 479431009827 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 479431009828 dimer interface [polypeptide binding]; other site 479431009829 active site 479431009830 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479431009831 catalytic residues [active] 479431009832 substrate binding site [chemical binding]; other site 479431009833 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479431009834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431009835 active site 479431009836 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 479431009837 AMP-binding enzyme; Region: AMP-binding; pfam00501 479431009838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431009839 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431009840 acyl-activating enzyme (AAE) consensus motif; other site 479431009841 acyl-activating enzyme (AAE) consensus motif; other site 479431009842 AMP binding site [chemical binding]; other site 479431009843 active site 479431009844 CoA binding site [chemical binding]; other site 479431009845 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 479431009846 Acyl transferase domain; Region: Acyl_transf_1; cl08282 479431009847 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479431009848 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 479431009849 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 479431009850 putative NAD(P) binding site [chemical binding]; other site 479431009851 active site 479431009852 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479431009853 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 479431009854 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 479431009855 active site 479431009856 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479431009857 active site 479431009858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431009859 NAD(P) binding site [chemical binding]; other site 479431009860 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 479431009861 active site 479431009862 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479431009863 DNA binding site [nucleotide binding] 479431009864 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479431009865 AAA domain; Region: AAA_22; pfam13401 479431009866 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431009867 MULE transposase domain; Region: MULE; pfam10551 479431009868 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 479431009869 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 479431009870 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 479431009871 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 479431009872 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 479431009873 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 479431009874 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 479431009875 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479431009876 Peptidase family M23; Region: Peptidase_M23; pfam01551 479431009877 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 479431009878 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479431009879 Transposase domain (DUF772); Region: DUF772; pfam05598 479431009880 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431009881 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431009882 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 479431009883 beta-galactosidase; Region: BGL; TIGR03356 479431009884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431009885 non-specific DNA binding site [nucleotide binding]; other site 479431009886 salt bridge; other site 479431009887 sequence-specific DNA binding site [nucleotide binding]; other site 479431009888 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431009889 Ligand Binding Site [chemical binding]; other site 479431009890 AAA domain; Region: AAA_30; pfam13604 479431009891 Family description; Region: UvrD_C_2; pfam13538 479431009892 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 479431009893 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 479431009894 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 479431009895 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 479431009896 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479431009897 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 479431009898 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 479431009899 Walker A/P-loop; other site 479431009900 ATP binding site [chemical binding]; other site 479431009901 Q-loop/lid; other site 479431009902 ABC transporter signature motif; other site 479431009903 Walker B; other site 479431009904 D-loop; other site 479431009905 H-loop/switch region; other site 479431009906 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 479431009907 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 479431009908 Walker A/P-loop; other site 479431009909 ATP binding site [chemical binding]; other site 479431009910 Q-loop/lid; other site 479431009911 ABC transporter signature motif; other site 479431009912 Walker B; other site 479431009913 D-loop; other site 479431009914 H-loop/switch region; other site 479431009915 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 479431009916 TM-ABC transporter signature motif; other site 479431009917 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 479431009918 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 479431009919 TM-ABC transporter signature motif; other site 479431009920 GAF domain; Region: GAF; pfam01590 479431009921 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479431009922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431009923 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 479431009924 NAD(P) binding site [chemical binding]; other site 479431009925 active site 479431009926 Lipase (class 2); Region: Lipase_2; pfam01674 479431009927 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431009928 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 479431009929 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 479431009930 DNA-binding site [nucleotide binding]; DNA binding site 479431009931 RNA-binding motif; other site 479431009932 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 479431009933 Cell division protein FtsQ; Region: FtsQ; pfam03799 479431009934 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 479431009935 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 479431009936 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479431009937 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479431009938 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 479431009939 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 479431009940 active site 479431009941 homodimer interface [polypeptide binding]; other site 479431009942 cell division protein FtsW; Region: ftsW; TIGR02614 479431009943 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479431009944 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 479431009945 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479431009946 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479431009947 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 479431009948 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 479431009949 Mg++ binding site [ion binding]; other site 479431009950 putative catalytic motif [active] 479431009951 putative substrate binding site [chemical binding]; other site 479431009952 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 479431009953 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 479431009954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479431009955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479431009956 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 479431009957 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 479431009958 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479431009959 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479431009960 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 479431009961 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 479431009962 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 479431009963 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 479431009964 MraW methylase family; Region: Methyltransf_5; cl17771 479431009965 cell division protein MraZ; Reviewed; Region: PRK00326 479431009966 MraZ protein; Region: MraZ; pfam02381 479431009967 MraZ protein; Region: MraZ; pfam02381 479431009968 Predicted membrane protein [Function unknown]; Region: COG2246 479431009969 GtrA-like protein; Region: GtrA; pfam04138 479431009970 MoxR-like ATPases [General function prediction only]; Region: COG0714 479431009971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431009972 Walker A motif; other site 479431009973 ATP binding site [chemical binding]; other site 479431009974 Walker B motif; other site 479431009975 arginine finger; other site 479431009976 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 479431009977 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 479431009978 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479431009979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431009980 S-adenosylmethionine binding site [chemical binding]; other site 479431009981 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 479431009982 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479431009983 Magnesium ion binding site [ion binding]; other site 479431009984 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479431009985 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479431009986 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 479431009987 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 479431009988 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 479431009989 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 479431009990 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479431009991 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 479431009992 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 479431009993 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479431009994 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 479431009995 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 479431009996 Transcription factor WhiB; Region: Whib; pfam02467 479431009997 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431009998 Ligand Binding Site [chemical binding]; other site 479431009999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431010000 MFS/sugar transport protein; Region: MFS_2; pfam13347 479431010001 putative substrate translocation pore; other site 479431010002 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479431010003 putative hydrophobic ligand binding site [chemical binding]; other site 479431010004 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431010005 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431010006 DNA binding site [nucleotide binding] 479431010007 domain linker motif; other site 479431010008 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431010009 ligand binding site [chemical binding]; other site 479431010010 dimerization interface [polypeptide binding]; other site 479431010011 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 479431010012 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 479431010013 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479431010014 metal ion-dependent adhesion site (MIDAS); other site 479431010015 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 479431010016 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 479431010017 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479431010018 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431010019 catalytic residue [active] 479431010020 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 479431010021 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431010022 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431010023 DNA binding site [nucleotide binding] 479431010024 domain linker motif; other site 479431010025 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431010026 dimerization interface [polypeptide binding]; other site 479431010027 ligand binding site [chemical binding]; other site 479431010028 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 479431010029 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 479431010030 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 479431010031 short chain dehydrogenase; Provisional; Region: PRK07060 479431010032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431010033 NAD(P) binding site [chemical binding]; other site 479431010034 active site 479431010035 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431010036 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431010037 DNA binding site [nucleotide binding] 479431010038 domain linker motif; other site 479431010039 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431010040 dimerization interface [polypeptide binding]; other site 479431010041 ligand binding site [chemical binding]; other site 479431010042 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 479431010043 active site 479431010044 catalytic residues [active] 479431010045 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431010046 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 479431010047 substrate binding site [chemical binding]; other site 479431010048 ATP binding site [chemical binding]; other site 479431010049 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 479431010050 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 479431010051 Class I aldolases; Region: Aldolase_Class_I; cl17187 479431010052 catalytic residue [active] 479431010053 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479431010054 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431010055 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 479431010056 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479431010057 Walker A/P-loop; other site 479431010058 ATP binding site [chemical binding]; other site 479431010059 Q-loop/lid; other site 479431010060 ABC transporter signature motif; other site 479431010061 Walker B; other site 479431010062 D-loop; other site 479431010063 H-loop/switch region; other site 479431010064 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479431010065 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479431010066 TM-ABC transporter signature motif; other site 479431010067 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 479431010068 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 479431010069 putative ligand binding site [chemical binding]; other site 479431010070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431010071 putative phosphatase; Provisional; Region: PRK11587 479431010072 active site 479431010073 motif I; other site 479431010074 motif II; other site 479431010075 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479431010076 nucleotide binding site [chemical binding]; other site 479431010077 Class I aldolases; Region: Aldolase_Class_I; cl17187 479431010078 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431010079 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431010080 DNA binding site [nucleotide binding] 479431010081 domain linker motif; other site 479431010082 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431010083 dimerization interface [polypeptide binding]; other site 479431010084 ligand binding site [chemical binding]; other site 479431010085 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 479431010086 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 479431010087 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 479431010088 active site 479431010089 dimer interface [polypeptide binding]; other site 479431010090 effector binding site; other site 479431010091 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 479431010092 TSCPD domain; Region: TSCPD; pfam12637 479431010093 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 479431010094 ATP cone domain; Region: ATP-cone; pfam03477 479431010095 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479431010096 LexA repressor; Validated; Region: PRK00215 479431010097 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431010098 putative DNA binding site [nucleotide binding]; other site 479431010099 putative Zn2+ binding site [ion binding]; other site 479431010100 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 479431010101 Catalytic site [active] 479431010102 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 479431010103 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 479431010104 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 479431010105 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 479431010106 HflX GTPase family; Region: HflX; cd01878 479431010107 G1 box; other site 479431010108 GTP/Mg2+ binding site [chemical binding]; other site 479431010109 Switch I region; other site 479431010110 G2 box; other site 479431010111 G3 box; other site 479431010112 Switch II region; other site 479431010113 G4 box; other site 479431010114 G5 box; other site 479431010115 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 479431010116 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 479431010117 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 479431010118 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 479431010119 IPP transferase; Region: IPPT; pfam01715 479431010120 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 479431010121 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 479431010122 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 479431010123 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 479431010124 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 479431010125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431010126 FeS/SAM binding site; other site 479431010127 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479431010128 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 479431010129 Walker A/P-loop; other site 479431010130 ATP binding site [chemical binding]; other site 479431010131 Q-loop/lid; other site 479431010132 ABC transporter signature motif; other site 479431010133 Walker B; other site 479431010134 D-loop; other site 479431010135 H-loop/switch region; other site 479431010136 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 479431010137 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479431010138 substrate binding pocket [chemical binding]; other site 479431010139 membrane-bound complex binding site; other site 479431010140 hinge residues; other site 479431010141 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479431010142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431010143 dimer interface [polypeptide binding]; other site 479431010144 conserved gate region; other site 479431010145 putative PBP binding loops; other site 479431010146 ABC-ATPase subunit interface; other site 479431010147 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431010148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431010149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431010150 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431010151 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479431010152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431010153 dimer interface [polypeptide binding]; other site 479431010154 conserved gate region; other site 479431010155 putative PBP binding loops; other site 479431010156 ABC-ATPase subunit interface; other site 479431010157 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 479431010158 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 479431010159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479431010160 Zn2+ binding site [ion binding]; other site 479431010161 Mg2+ binding site [ion binding]; other site 479431010162 RecX family; Region: RecX; pfam02631 479431010163 recombinase A; Provisional; Region: recA; PRK09354 479431010164 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 479431010165 hexamer interface [polypeptide binding]; other site 479431010166 Walker A motif; other site 479431010167 ATP binding site [chemical binding]; other site 479431010168 Walker B motif; other site 479431010169 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 479431010170 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479431010171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431010172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431010173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431010174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431010175 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 479431010176 glycine dehydrogenase; Provisional; Region: PRK05367 479431010177 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 479431010178 tetramer interface [polypeptide binding]; other site 479431010179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431010180 catalytic residue [active] 479431010181 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 479431010182 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431010183 catalytic residue [active] 479431010184 H+ Antiporter protein; Region: 2A0121; TIGR00900 479431010185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431010186 putative substrate translocation pore; other site 479431010187 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431010188 MarR family; Region: MarR; pfam01047 479431010189 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 479431010190 DNA binding residues [nucleotide binding] 479431010191 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479431010192 putative dimer interface [polypeptide binding]; other site 479431010193 Bifunctional nuclease; Region: DNase-RNase; pfam02577 479431010194 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479431010195 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479431010196 DNA binding residues [nucleotide binding] 479431010197 dimer interface [polypeptide binding]; other site 479431010198 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 479431010199 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479431010200 phosphopeptide binding site; other site 479431010201 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 479431010202 lipoyl attachment site [posttranslational modification]; other site 479431010203 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 479431010204 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 479431010205 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 479431010206 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 479431010207 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 479431010208 dimer interface [polypeptide binding]; other site 479431010209 ADP-ribose binding site [chemical binding]; other site 479431010210 active site 479431010211 nudix motif; other site 479431010212 metal binding site [ion binding]; metal-binding site 479431010213 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 479431010214 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 479431010215 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479431010216 TIGR03086 family protein; Region: TIGR03086 479431010217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479431010218 active site 479431010219 OsmC-like protein; Region: OsmC; cl00767 479431010220 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431010221 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431010222 DNA binding site [nucleotide binding] 479431010223 domain linker motif; other site 479431010224 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479431010225 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 479431010226 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 479431010227 L-aspartate oxidase; Provisional; Region: PRK06175 479431010228 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 479431010229 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 479431010230 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479431010231 catalytic loop [active] 479431010232 iron binding site [ion binding]; other site 479431010233 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431010234 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431010235 active site 479431010236 ATP binding site [chemical binding]; other site 479431010237 substrate binding site [chemical binding]; other site 479431010238 activation loop (A-loop); other site 479431010239 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479431010240 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 479431010241 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479431010242 active site 479431010243 catalytic site [active] 479431010244 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431010245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431010246 non-specific DNA binding site [nucleotide binding]; other site 479431010247 salt bridge; other site 479431010248 sequence-specific DNA binding site [nucleotide binding]; other site 479431010249 Benzoate membrane transport protein; Region: BenE; pfam03594 479431010250 benzoate transporter; Region: benE; TIGR00843 479431010251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431010252 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 479431010253 ATP binding site [chemical binding]; other site 479431010254 putative Mg++ binding site [ion binding]; other site 479431010255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431010256 nucleotide binding region [chemical binding]; other site 479431010257 ATP-binding site [chemical binding]; other site 479431010258 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479431010259 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479431010260 DNA binding residues [nucleotide binding] 479431010261 dimer interface [polypeptide binding]; other site 479431010262 TIGR03086 family protein; Region: TIGR03086 479431010263 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479431010264 Helix-turn-helix domain; Region: HTH_18; pfam12833 479431010265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479431010266 Helix-turn-helix domain; Region: HTH_31; pfam13560 479431010267 short chain dehydrogenase; Provisional; Region: PRK05854 479431010268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431010269 NAD(P) binding site [chemical binding]; other site 479431010270 active site 479431010271 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431010272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431010273 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479431010274 active site 479431010275 TDP-binding site; other site 479431010276 acceptor substrate-binding pocket; other site 479431010277 PAS domain; Region: PAS_9; pfam13426 479431010278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479431010279 putative active site [active] 479431010280 heme pocket [chemical binding]; other site 479431010281 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431010282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431010283 metal binding site [ion binding]; metal-binding site 479431010284 active site 479431010285 I-site; other site 479431010286 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 479431010287 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479431010288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431010289 S-adenosylmethionine binding site [chemical binding]; other site 479431010290 Domain of unknown function (DUF222); Region: DUF222; pfam02720 479431010291 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479431010292 active site 479431010293 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 479431010294 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 479431010295 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 479431010296 GTP-binding protein Der; Reviewed; Region: PRK03003 479431010297 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 479431010298 G1 box; other site 479431010299 GTP/Mg2+ binding site [chemical binding]; other site 479431010300 Switch I region; other site 479431010301 G2 box; other site 479431010302 Switch II region; other site 479431010303 G3 box; other site 479431010304 G4 box; other site 479431010305 G5 box; other site 479431010306 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 479431010307 G1 box; other site 479431010308 GTP/Mg2+ binding site [chemical binding]; other site 479431010309 Switch I region; other site 479431010310 G2 box; other site 479431010311 G3 box; other site 479431010312 Switch II region; other site 479431010313 G4 box; other site 479431010314 G5 box; other site 479431010315 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479431010316 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479431010317 putative acyl-acceptor binding pocket; other site 479431010318 cytidylate kinase; Provisional; Region: cmk; PRK00023 479431010319 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 479431010320 CMP-binding site; other site 479431010321 The sites determining sugar specificity; other site 479431010322 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 479431010323 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 479431010324 RNA binding surface [nucleotide binding]; other site 479431010325 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 479431010326 active site 479431010327 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 479431010328 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 479431010329 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479431010330 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479431010331 P-loop; other site 479431010332 Magnesium ion binding site [ion binding]; other site 479431010333 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 479431010334 Domain of unknown function DUF20; Region: UPF0118; pfam01594 479431010335 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 479431010336 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 479431010337 Hemerythrin-like domain; Region: Hr-like; cd12108 479431010338 Fe binding site [ion binding]; other site 479431010339 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 479431010340 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479431010341 active site 479431010342 DNA binding site [nucleotide binding] 479431010343 Int/Topo IB signature motif; other site 479431010344 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 479431010345 dimer interface [polypeptide binding]; other site 479431010346 ADP-ribose binding site [chemical binding]; other site 479431010347 active site 479431010348 nudix motif; other site 479431010349 metal binding site [ion binding]; metal-binding site 479431010350 CTP synthetase; Validated; Region: pyrG; PRK05380 479431010351 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 479431010352 Catalytic site [active] 479431010353 active site 479431010354 UTP binding site [chemical binding]; other site 479431010355 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 479431010356 active site 479431010357 putative oxyanion hole; other site 479431010358 catalytic triad [active] 479431010359 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 479431010360 FtsX-like permease family; Region: FtsX; pfam02687 479431010361 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479431010362 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479431010363 Walker A/P-loop; other site 479431010364 ATP binding site [chemical binding]; other site 479431010365 Q-loop/lid; other site 479431010366 ABC transporter signature motif; other site 479431010367 Walker B; other site 479431010368 D-loop; other site 479431010369 H-loop/switch region; other site 479431010370 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431010371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431010372 active site 479431010373 phosphorylation site [posttranslational modification] 479431010374 intermolecular recognition site; other site 479431010375 dimerization interface [polypeptide binding]; other site 479431010376 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431010377 DNA binding residues [nucleotide binding] 479431010378 dimerization interface [polypeptide binding]; other site 479431010379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431010380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431010381 ATP binding site [chemical binding]; other site 479431010382 Mg2+ binding site [ion binding]; other site 479431010383 G-X-G motif; other site 479431010384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431010385 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431010386 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 479431010387 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 479431010388 Thiamine pyrophosphokinase; Region: TPK; cl08415 479431010389 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 479431010390 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 479431010391 Walker A/P-loop; other site 479431010392 ATP binding site [chemical binding]; other site 479431010393 Q-loop/lid; other site 479431010394 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 479431010395 ABC transporter signature motif; other site 479431010396 Walker B; other site 479431010397 D-loop; other site 479431010398 H-loop/switch region; other site 479431010399 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 479431010400 ATP-NAD kinase; Region: NAD_kinase; pfam01513 479431010401 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 479431010402 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 479431010403 RNA binding surface [nucleotide binding]; other site 479431010404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431010405 S-adenosylmethionine binding site [chemical binding]; other site 479431010406 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 479431010407 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 479431010408 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 479431010409 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479431010410 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 479431010411 pyruvate phosphate dikinase; Provisional; Region: PRK09279 479431010412 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 479431010413 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 479431010414 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 479431010415 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 479431010416 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 479431010417 active site 479431010418 catalytic residues [active] 479431010419 metal binding site [ion binding]; metal-binding site 479431010420 DmpG-like communication domain; Region: DmpG_comm; pfam07836 479431010421 acetaldehyde dehydrogenase; Validated; Region: PRK08300 479431010422 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 479431010423 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 479431010424 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431010425 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479431010426 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431010427 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 479431010428 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 479431010429 AAA ATPase domain; Region: AAA_16; pfam13191 479431010430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431010431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431010432 DNA binding residues [nucleotide binding] 479431010433 dimerization interface [polypeptide binding]; other site 479431010434 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431010435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431010436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479431010437 dimerization interface [polypeptide binding]; other site 479431010438 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 479431010439 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431010440 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431010441 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 479431010442 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 479431010443 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479431010444 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 479431010445 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 479431010446 dimer interface [polypeptide binding]; other site 479431010447 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479431010448 active site 479431010449 metal binding site [ion binding]; metal-binding site 479431010450 hypothetical protein; Provisional; Region: PRK12839 479431010451 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479431010452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431010453 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431010454 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479431010455 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431010456 Dehydroquinase class II; Region: DHquinase_II; pfam01220 479431010457 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 479431010458 trimer interface [polypeptide binding]; other site 479431010459 active site 479431010460 dimer interface [polypeptide binding]; other site 479431010461 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 479431010462 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 479431010463 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 479431010464 shikimate binding site; other site 479431010465 NAD(P) binding site [chemical binding]; other site 479431010466 Amidohydrolase; Region: Amidohydro_2; pfam04909 479431010467 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 479431010468 dimer interface [polypeptide binding]; other site 479431010469 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 479431010470 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 479431010471 active site 479431010472 Fe(II) binding site [ion binding]; other site 479431010473 dimer interface [polypeptide binding]; other site 479431010474 tetramer interface [polypeptide binding]; other site 479431010475 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479431010476 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431010477 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479431010478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 479431010479 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479431010480 E3 interaction surface; other site 479431010481 lipoyl attachment site [posttranslational modification]; other site 479431010482 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 479431010483 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479431010484 E3 interaction surface; other site 479431010485 lipoyl attachment site [posttranslational modification]; other site 479431010486 e3 binding domain; Region: E3_binding; pfam02817 479431010487 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479431010488 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 479431010489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431010490 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479431010491 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479431010492 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 479431010493 alpha subunit interface [polypeptide binding]; other site 479431010494 TPP binding site [chemical binding]; other site 479431010495 heterodimer interface [polypeptide binding]; other site 479431010496 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479431010497 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479431010498 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 479431010499 tetramer interface [polypeptide binding]; other site 479431010500 TPP-binding site [chemical binding]; other site 479431010501 heterodimer interface [polypeptide binding]; other site 479431010502 phosphorylation loop region [posttranslational modification] 479431010503 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 479431010504 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 479431010505 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 479431010506 putative active site [active] 479431010507 putative catalytic site [active] 479431010508 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479431010509 Dodecin; Region: Dodecin; pfam07311 479431010510 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479431010511 anti sigma factor interaction site; other site 479431010512 regulatory phosphorylation site [posttranslational modification]; other site 479431010513 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 479431010514 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 479431010515 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 479431010516 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 479431010517 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479431010518 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 479431010519 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 479431010520 Soluble P-type ATPase [General function prediction only]; Region: COG4087 479431010521 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 479431010522 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 479431010523 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 479431010524 active site 479431010525 HIGH motif; other site 479431010526 dimer interface [polypeptide binding]; other site 479431010527 KMSKS motif; other site 479431010528 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 479431010529 active site 479431010530 DNA binding site [nucleotide binding] 479431010531 argininosuccinate lyase; Provisional; Region: PRK00855 479431010532 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 479431010533 active sites [active] 479431010534 tetramer interface [polypeptide binding]; other site 479431010535 argininosuccinate synthase; Validated; Region: PRK05370 479431010536 arginine repressor; Provisional; Region: PRK03341 479431010537 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 479431010538 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 479431010539 ornithine carbamoyltransferase; Provisional; Region: PRK00779 479431010540 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 479431010541 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 479431010542 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 479431010543 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479431010544 inhibitor-cofactor binding pocket; inhibition site 479431010545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431010546 catalytic residue [active] 479431010547 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 479431010548 feedback inhibition sensing region; other site 479431010549 homohexameric interface [polypeptide binding]; other site 479431010550 nucleotide binding site [chemical binding]; other site 479431010551 N-acetyl-L-glutamate binding site [chemical binding]; other site 479431010552 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 479431010553 heterotetramer interface [polypeptide binding]; other site 479431010554 active site pocket [active] 479431010555 cleavage site 479431010556 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 479431010557 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 479431010558 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431010559 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431010560 active site 479431010561 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 479431010562 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 479431010563 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 479431010564 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 479431010565 putative tRNA-binding site [nucleotide binding]; other site 479431010566 B3/4 domain; Region: B3_4; pfam03483 479431010567 tRNA synthetase B5 domain; Region: B5; smart00874 479431010568 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 479431010569 dimer interface [polypeptide binding]; other site 479431010570 motif 1; other site 479431010571 motif 3; other site 479431010572 motif 2; other site 479431010573 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 479431010574 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 479431010575 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 479431010576 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 479431010577 dimer interface [polypeptide binding]; other site 479431010578 motif 1; other site 479431010579 active site 479431010580 motif 2; other site 479431010581 motif 3; other site 479431010582 Transcription factor WhiB; Region: Whib; pfam02467 479431010583 malate dehydrogenase; Provisional; Region: PRK13529 479431010584 Malic enzyme, N-terminal domain; Region: malic; pfam00390 479431010585 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 479431010586 NAD(P) binding pocket [chemical binding]; other site 479431010587 PemK-like protein; Region: PemK; pfam02452 479431010588 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 479431010589 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 479431010590 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 479431010591 23S rRNA binding site [nucleotide binding]; other site 479431010592 L21 binding site [polypeptide binding]; other site 479431010593 L13 binding site [polypeptide binding]; other site 479431010594 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 479431010595 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 479431010596 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 479431010597 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 479431010598 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 479431010599 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 479431010600 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 479431010601 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 479431010602 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 479431010603 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 479431010604 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479431010605 catalytic loop [active] 479431010606 iron binding site [ion binding]; other site 479431010607 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 479431010608 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 479431010609 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 479431010610 homopentamer interface [polypeptide binding]; other site 479431010611 active site 479431010612 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 479431010613 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 479431010614 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 479431010615 dimerization interface [polypeptide binding]; other site 479431010616 active site 479431010617 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 479431010618 Lumazine binding domain; Region: Lum_binding; pfam00677 479431010619 Lumazine binding domain; Region: Lum_binding; pfam00677 479431010620 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 479431010621 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 479431010622 substrate binding site [chemical binding]; other site 479431010623 hexamer interface [polypeptide binding]; other site 479431010624 metal binding site [ion binding]; metal-binding site 479431010625 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 479431010626 putative RNA binding site [nucleotide binding]; other site 479431010627 16S rRNA methyltransferase B; Provisional; Region: PRK14902 479431010628 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 479431010629 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 479431010630 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 479431010631 putative active site [active] 479431010632 substrate binding site [chemical binding]; other site 479431010633 putative cosubstrate binding site; other site 479431010634 catalytic site [active] 479431010635 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 479431010636 substrate binding site [chemical binding]; other site 479431010637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479431010638 primosome assembly protein PriA; Provisional; Region: PRK14873 479431010639 S-adenosylmethionine synthetase; Validated; Region: PRK05250 479431010640 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 479431010641 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 479431010642 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 479431010643 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 479431010644 Flavoprotein; Region: Flavoprotein; pfam02441 479431010645 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 479431010646 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 479431010647 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 479431010648 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 479431010649 catalytic site [active] 479431010650 G-X2-G-X-G-K; other site 479431010651 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 479431010652 amino acid transporter; Region: 2A0306; TIGR00909 479431010653 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 479431010654 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 479431010655 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 479431010656 Trm112p-like protein; Region: Trm112p; cl01066 479431010657 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 479431010658 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 479431010659 active site 479431010660 substrate binding site [chemical binding]; other site 479431010661 metal binding site [ion binding]; metal-binding site 479431010662 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 479431010663 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 479431010664 hypothetical protein; Provisional; Region: PRK11770 479431010665 Domain of unknown function (DUF307); Region: DUF307; pfam03733 479431010666 Domain of unknown function (DUF307); Region: DUF307; pfam03733 479431010667 Transcription factor WhiB; Region: Whib; pfam02467 479431010668 Peptidase family M50; Region: Peptidase_M50; pfam02163 479431010669 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 479431010670 active site 479431010671 putative substrate binding region [chemical binding]; other site 479431010672 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 479431010673 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 479431010674 active site 479431010675 metal binding site [ion binding]; metal-binding site 479431010676 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 479431010677 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 479431010678 phosphate binding site [ion binding]; other site 479431010679 dimer interface [polypeptide binding]; other site 479431010680 substrate binding site [chemical binding]; other site 479431010681 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 479431010682 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 479431010683 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 479431010684 FMN binding site [chemical binding]; other site 479431010685 dimer interface [polypeptide binding]; other site 479431010686 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 479431010687 nudix motif; other site 479431010688 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 479431010689 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 479431010690 PKC phosphorylation site [posttranslational modification]; other site 479431010691 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 479431010692 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 479431010693 active site 479431010694 Substrate binding site; other site 479431010695 Mg++ binding site; other site 479431010696 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 479431010697 putative CoA binding site [chemical binding]; other site 479431010698 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 479431010699 putative trimer interface [polypeptide binding]; other site 479431010700 putative CoA binding site [chemical binding]; other site 479431010701 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 479431010702 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 479431010703 substrate binding site; other site 479431010704 tetramer interface; other site 479431010705 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479431010706 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 479431010707 Probable Catalytic site; other site 479431010708 metal-binding site 479431010709 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 479431010710 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431010711 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431010712 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 479431010713 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431010714 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479431010715 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 479431010716 Probable Catalytic site; other site 479431010717 metal-binding site 479431010718 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 479431010719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479431010720 UDP-galactopyranose mutase; Region: GLF; pfam03275 479431010721 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 479431010722 Ligand binding site; other site 479431010723 Putative Catalytic site; other site 479431010724 DXD motif; other site 479431010725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431010726 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 479431010727 NAD(P) binding site [chemical binding]; other site 479431010728 active site 479431010729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431010730 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479431010731 NAD(P) binding site [chemical binding]; other site 479431010732 active site 479431010733 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 479431010734 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 479431010735 Ligand binding site; other site 479431010736 Putative Catalytic site; other site 479431010737 DXD motif; other site 479431010738 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 479431010739 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 479431010740 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 479431010741 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 479431010742 Rhamnan synthesis protein F; Region: RgpF; pfam05045 479431010743 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 479431010744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431010745 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479431010746 NAD(P) binding site [chemical binding]; other site 479431010747 active site 479431010748 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 479431010749 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 479431010750 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479431010751 active site 479431010752 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479431010753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431010754 NAD(P) binding site [chemical binding]; other site 479431010755 active site 479431010756 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 479431010757 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431010758 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479431010759 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 479431010760 Probable Catalytic site; other site 479431010761 metal-binding site 479431010762 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479431010763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431010764 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 479431010765 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 479431010766 Walker A/P-loop; other site 479431010767 ATP binding site [chemical binding]; other site 479431010768 Q-loop/lid; other site 479431010769 ABC transporter signature motif; other site 479431010770 Walker B; other site 479431010771 D-loop; other site 479431010772 H-loop/switch region; other site 479431010773 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 479431010774 putative carbohydrate binding site [chemical binding]; other site 479431010775 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 479431010776 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479431010777 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 479431010778 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 479431010779 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 479431010780 Ligand binding site; other site 479431010781 Putative Catalytic site; other site 479431010782 DXD motif; other site 479431010783 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 479431010784 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 479431010785 NADP binding site [chemical binding]; other site 479431010786 active site 479431010787 putative substrate binding site [chemical binding]; other site 479431010788 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 479431010789 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 479431010790 NAD binding site [chemical binding]; other site 479431010791 substrate binding site [chemical binding]; other site 479431010792 homodimer interface [polypeptide binding]; other site 479431010793 active site 479431010794 Transcriptional regulator [Transcription]; Region: LytR; COG1316 479431010795 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 479431010796 TIGR03089 family protein; Region: TIGR03089 479431010797 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479431010798 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431010799 active site 479431010800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431010801 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431010802 dimerization interface [polypeptide binding]; other site 479431010803 putative DNA binding site [nucleotide binding]; other site 479431010804 putative Zn2+ binding site [ion binding]; other site 479431010805 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 479431010806 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 479431010807 ATP-grasp domain; Region: ATP-grasp; pfam02222 479431010808 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479431010809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431010810 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431010811 DNA binding residues [nucleotide binding] 479431010812 Putative zinc-finger; Region: zf-HC2; pfam13490 479431010813 Predicted membrane protein [Function unknown]; Region: COG2246 479431010814 GtrA-like protein; Region: GtrA; pfam04138 479431010815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431010816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431010817 ATP binding site [chemical binding]; other site 479431010818 Mg2+ binding site [ion binding]; other site 479431010819 G-X-G motif; other site 479431010820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431010821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431010822 active site 479431010823 phosphorylation site [posttranslational modification] 479431010824 intermolecular recognition site; other site 479431010825 dimerization interface [polypeptide binding]; other site 479431010826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431010827 DNA binding site [nucleotide binding] 479431010828 Bacterial PH domain; Region: DUF304; pfam03703 479431010829 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 479431010830 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479431010831 catalytic residue [active] 479431010832 conserved repeat domain; Region: B_ant_repeat; TIGR01451 479431010833 Domain of unknown function DUF11; Region: DUF11; cl17728 479431010834 Domain of unknown function DUF11; Region: DUF11; pfam01345 479431010835 Domain of unknown function DUF11; Region: DUF11; pfam01345 479431010836 Domain of unknown function DUF11; Region: DUF11; pfam01345 479431010837 Domain of unknown function DUF11; Region: DUF11; pfam01345 479431010838 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 479431010839 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 479431010840 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 479431010841 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 479431010842 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 479431010843 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 479431010844 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 479431010845 active site 479431010846 dimer interface [polypeptide binding]; other site 479431010847 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479431010848 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 479431010849 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 479431010850 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 479431010851 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 479431010852 carboxyltransferase (CT) interaction site; other site 479431010853 biotinylation site [posttranslational modification]; other site 479431010854 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479431010855 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 479431010856 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 479431010857 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 479431010858 active site 479431010859 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479431010860 active site 479431010861 Acyl transferase domain; Region: Acyl_transf_1; cl08282 479431010862 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 479431010863 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 479431010864 active site 1 [active] 479431010865 dimer interface [polypeptide binding]; other site 479431010866 active site 2 [active] 479431010867 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 479431010868 active site 1 [active] 479431010869 dimer interface [polypeptide binding]; other site 479431010870 active site 2 [active] 479431010871 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 479431010872 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 479431010873 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 479431010874 active site 479431010875 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 479431010876 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 479431010877 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 479431010878 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 479431010879 putative NADP binding site [chemical binding]; other site 479431010880 active site 479431010881 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 479431010882 phosphate binding site [ion binding]; other site 479431010883 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 479431010884 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479431010885 active site 479431010886 haloalkane dehalogenase; Provisional; Region: PRK03592 479431010887 peptide synthase; Provisional; Region: PRK09274 479431010888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431010889 acyl-activating enzyme (AAE) consensus motif; other site 479431010890 AMP binding site [chemical binding]; other site 479431010891 active site 479431010892 CoA binding site [chemical binding]; other site 479431010893 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479431010894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431010895 NAD(P) binding site [chemical binding]; other site 479431010896 active site 479431010897 Predicted transcriptional regulators [Transcription]; Region: COG1733 479431010898 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479431010899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431010900 NAD(P) binding site [chemical binding]; other site 479431010901 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 479431010902 active site 479431010903 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479431010904 lipoprotein LpqB; Provisional; Region: PRK13616 479431010905 Sporulation and spore germination; Region: Germane; pfam10646 479431010906 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 479431010907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431010908 dimerization interface [polypeptide binding]; other site 479431010909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431010910 dimer interface [polypeptide binding]; other site 479431010911 phosphorylation site [posttranslational modification] 479431010912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431010913 ATP binding site [chemical binding]; other site 479431010914 Mg2+ binding site [ion binding]; other site 479431010915 G-X-G motif; other site 479431010916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431010917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431010918 active site 479431010919 phosphorylation site [posttranslational modification] 479431010920 intermolecular recognition site; other site 479431010921 dimerization interface [polypeptide binding]; other site 479431010922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431010923 DNA binding site [nucleotide binding] 479431010924 thymidylate kinase; Validated; Region: PRK07933 479431010925 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 479431010926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431010927 putative substrate translocation pore; other site 479431010928 POT family; Region: PTR2; cl17359 479431010929 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 479431010930 active site 479431010931 dimer interface [polypeptide binding]; other site 479431010932 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 479431010933 Short C-terminal domain; Region: SHOCT; pfam09851 479431010934 Adenosylhomocysteinase; Provisional; Region: PTZ00075 479431010935 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 479431010936 homotetramer interface [polypeptide binding]; other site 479431010937 ligand binding site [chemical binding]; other site 479431010938 catalytic site [active] 479431010939 NAD binding site [chemical binding]; other site 479431010940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431010941 putative substrate translocation pore; other site 479431010942 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431010943 FO synthase; Reviewed; Region: fbiC; PRK09234 479431010944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431010945 FeS/SAM binding site; other site 479431010946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431010947 FeS/SAM binding site; other site 479431010948 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479431010949 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 479431010950 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 479431010951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431010952 active site 479431010953 motif I; other site 479431010954 motif II; other site 479431010955 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 479431010956 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479431010957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431010958 S-adenosylmethionine binding site [chemical binding]; other site 479431010959 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 479431010960 active site 479431010961 catalytic residues [active] 479431010962 metal binding site [ion binding]; metal-binding site 479431010963 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 479431010964 Dehydratase family; Region: ILVD_EDD; cl00340 479431010965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431010966 non-specific DNA binding site [nucleotide binding]; other site 479431010967 sequence-specific DNA binding site [nucleotide binding]; other site 479431010968 salt bridge; other site 479431010969 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431010970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431010971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479431010972 dimerization interface [polypeptide binding]; other site 479431010973 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431010974 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431010975 DNA binding site [nucleotide binding] 479431010976 domain linker motif; other site 479431010977 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479431010978 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 479431010979 active site 479431010980 dimer interface [polypeptide binding]; other site 479431010981 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 479431010982 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431010983 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 479431010984 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 479431010985 quinone interaction residues [chemical binding]; other site 479431010986 active site 479431010987 catalytic residues [active] 479431010988 FMN binding site [chemical binding]; other site 479431010989 substrate binding site [chemical binding]; other site 479431010990 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 479431010991 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479431010992 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431010993 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 479431010994 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479431010995 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431010996 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 479431010997 IMP binding site; other site 479431010998 dimer interface [polypeptide binding]; other site 479431010999 partial ornithine binding site; other site 479431011000 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 479431011001 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 479431011002 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 479431011003 catalytic site [active] 479431011004 subunit interface [polypeptide binding]; other site 479431011005 dihydroorotase, multifunctional complex type; Region: pyrC_multi; TIGR00857 479431011006 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 479431011007 active site 479431011008 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 479431011009 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 479431011010 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 479431011011 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 479431011012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479431011013 active site 479431011014 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431011015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431011016 non-specific DNA binding site [nucleotide binding]; other site 479431011017 salt bridge; other site 479431011018 sequence-specific DNA binding site [nucleotide binding]; other site 479431011019 transcription antitermination factor NusB; Region: nusB; TIGR01951 479431011020 putative RNA binding site [nucleotide binding]; other site 479431011021 elongation factor P; Validated; Region: PRK00529 479431011022 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 479431011023 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 479431011024 RNA binding site [nucleotide binding]; other site 479431011025 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 479431011026 RNA binding site [nucleotide binding]; other site 479431011027 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 479431011028 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 479431011029 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 479431011030 active site 479431011031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431011032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431011033 DNA binding site [nucleotide binding] 479431011034 domain linker motif; other site 479431011035 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431011036 ligand binding site [chemical binding]; other site 479431011037 dimerization interface [polypeptide binding]; other site 479431011038 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 479431011039 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 479431011040 putative ligand binding site [chemical binding]; other site 479431011041 NAD binding site [chemical binding]; other site 479431011042 dimer interface [polypeptide binding]; other site 479431011043 putative catalytic site [active] 479431011044 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 479431011045 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 479431011046 metal binding site [ion binding]; metal-binding site 479431011047 substrate binding pocket [chemical binding]; other site 479431011048 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 479431011049 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 479431011050 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 479431011051 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431011052 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 479431011053 inhibitor binding site; inhibition site 479431011054 catalytic Zn binding site [ion binding]; other site 479431011055 structural Zn binding site [ion binding]; other site 479431011056 NADP binding site [chemical binding]; other site 479431011057 tetramer interface [polypeptide binding]; other site 479431011058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431011059 metabolite-proton symporter; Region: 2A0106; TIGR00883 479431011060 putative substrate translocation pore; other site 479431011061 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 479431011062 substrate binding site [chemical binding]; other site 479431011063 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431011064 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431011065 ATP binding site [chemical binding]; other site 479431011066 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 479431011067 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 479431011068 active site 479431011069 intersubunit interface [polypeptide binding]; other site 479431011070 catalytic residue [active] 479431011071 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 479431011072 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 479431011073 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 479431011074 potential catalytic triad [active] 479431011075 conserved cys residue [active] 479431011076 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431011077 active site 479431011078 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 479431011079 active site 479431011080 dimer interface [polypeptide binding]; other site 479431011081 metal binding site [ion binding]; metal-binding site 479431011082 shikimate kinase; Reviewed; Region: aroK; PRK00131 479431011083 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 479431011084 ADP binding site [chemical binding]; other site 479431011085 magnesium binding site [ion binding]; other site 479431011086 putative shikimate binding site; other site 479431011087 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 479431011088 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 479431011089 Tetramer interface [polypeptide binding]; other site 479431011090 active site 479431011091 FMN-binding site [chemical binding]; other site 479431011092 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 479431011093 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 479431011094 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 479431011095 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 479431011096 metal binding site [ion binding]; metal-binding site 479431011097 putative dimer interface [polypeptide binding]; other site 479431011098 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479431011099 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 479431011100 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 479431011101 putative trimer interface [polypeptide binding]; other site 479431011102 putative CoA binding site [chemical binding]; other site 479431011103 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 479431011104 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 479431011105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431011106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431011107 homodimer interface [polypeptide binding]; other site 479431011108 catalytic residue [active] 479431011109 Ferredoxin [Energy production and conversion]; Region: COG1146 479431011110 4Fe-4S binding domain; Region: Fer4; pfam00037 479431011111 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479431011112 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 479431011113 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479431011114 Walker A/P-loop; other site 479431011115 ATP binding site [chemical binding]; other site 479431011116 Q-loop/lid; other site 479431011117 ABC transporter signature motif; other site 479431011118 Walker B; other site 479431011119 D-loop; other site 479431011120 H-loop/switch region; other site 479431011121 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 479431011122 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479431011123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479431011124 Walker A/P-loop; other site 479431011125 ATP binding site [chemical binding]; other site 479431011126 Q-loop/lid; other site 479431011127 ABC transporter signature motif; other site 479431011128 Walker B; other site 479431011129 D-loop; other site 479431011130 H-loop/switch region; other site 479431011131 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479431011132 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 479431011133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431011134 dimer interface [polypeptide binding]; other site 479431011135 conserved gate region; other site 479431011136 ABC-ATPase subunit interface; other site 479431011137 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479431011138 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479431011139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431011140 putative PBP binding loops; other site 479431011141 dimer interface [polypeptide binding]; other site 479431011142 ABC-ATPase subunit interface; other site 479431011143 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 479431011144 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479431011145 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 479431011146 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479431011147 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 479431011148 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 479431011149 G1 box; other site 479431011150 putative GEF interaction site [polypeptide binding]; other site 479431011151 GTP/Mg2+ binding site [chemical binding]; other site 479431011152 Switch I region; other site 479431011153 G2 box; other site 479431011154 G3 box; other site 479431011155 Switch II region; other site 479431011156 G4 box; other site 479431011157 G5 box; other site 479431011158 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 479431011159 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 479431011160 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479431011161 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 479431011162 Walker A/P-loop; other site 479431011163 ATP binding site [chemical binding]; other site 479431011164 Q-loop/lid; other site 479431011165 ABC transporter signature motif; other site 479431011166 Walker B; other site 479431011167 D-loop; other site 479431011168 H-loop/switch region; other site 479431011169 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479431011170 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479431011171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431011172 dimer interface [polypeptide binding]; other site 479431011173 conserved gate region; other site 479431011174 putative PBP binding loops; other site 479431011175 ABC-ATPase subunit interface; other site 479431011176 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 479431011177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479431011178 substrate binding pocket [chemical binding]; other site 479431011179 membrane-bound complex binding site; other site 479431011180 hinge residues; other site 479431011181 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479431011182 nudix motif; other site 479431011183 mannosyltransferase; Provisional; Region: pimE; PRK13375 479431011184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431011185 dimerization interface [polypeptide binding]; other site 479431011186 putative DNA binding site [nucleotide binding]; other site 479431011187 putative Zn2+ binding site [ion binding]; other site 479431011188 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479431011189 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431011190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431011191 homodimer interface [polypeptide binding]; other site 479431011192 catalytic residue [active] 479431011193 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 479431011194 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 479431011195 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 479431011196 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 479431011197 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 479431011198 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479431011199 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479431011200 putative NAD(P) binding site [chemical binding]; other site 479431011201 carboxylate-amine ligase; Provisional; Region: PRK13517 479431011202 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 479431011203 Transposase domain (DUF772); Region: DUF772; pfam05598 479431011204 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431011205 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431011206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 479431011207 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 479431011208 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 479431011209 Walker A/P-loop; other site 479431011210 ATP binding site [chemical binding]; other site 479431011211 Q-loop/lid; other site 479431011212 ABC transporter signature motif; other site 479431011213 Walker B; other site 479431011214 D-loop; other site 479431011215 H-loop/switch region; other site 479431011216 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 479431011217 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 479431011218 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 479431011219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479431011220 substrate binding pocket [chemical binding]; other site 479431011221 membrane-bound complex binding site; other site 479431011222 hinge residues; other site 479431011223 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 479431011224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431011225 dimer interface [polypeptide binding]; other site 479431011226 conserved gate region; other site 479431011227 putative PBP binding loops; other site 479431011228 ABC-ATPase subunit interface; other site 479431011229 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 479431011230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431011231 Walker A/P-loop; other site 479431011232 ATP binding site [chemical binding]; other site 479431011233 Q-loop/lid; other site 479431011234 ABC transporter signature motif; other site 479431011235 Walker B; other site 479431011236 D-loop; other site 479431011237 H-loop/switch region; other site 479431011238 FAD binding domain; Region: FAD_binding_4; pfam01565 479431011239 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 479431011240 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479431011241 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 479431011242 Walker A/P-loop; other site 479431011243 ATP binding site [chemical binding]; other site 479431011244 Q-loop/lid; other site 479431011245 ABC transporter signature motif; other site 479431011246 Walker B; other site 479431011247 D-loop; other site 479431011248 H-loop/switch region; other site 479431011249 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 479431011250 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479431011251 substrate binding pocket [chemical binding]; other site 479431011252 membrane-bound complex binding site; other site 479431011253 hinge residues; other site 479431011254 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 479431011255 hydroxyglutarate oxidase; Provisional; Region: PRK11728 479431011256 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 479431011257 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479431011258 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479431011259 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 479431011260 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 479431011261 active site 479431011262 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 479431011263 dimer interface [polypeptide binding]; other site 479431011264 non-prolyl cis peptide bond; other site 479431011265 insertion regions; other site 479431011266 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 479431011267 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479431011268 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 479431011269 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431011270 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 479431011271 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 479431011272 active site 479431011273 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 479431011274 non-prolyl cis peptide bond; other site 479431011275 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431011276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431011277 Coenzyme A binding pocket [chemical binding]; other site 479431011278 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 479431011279 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 479431011280 active site clefts [active] 479431011281 zinc binding site [ion binding]; other site 479431011282 dimer interface [polypeptide binding]; other site 479431011283 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 479431011284 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 479431011285 hexamer interface [polypeptide binding]; other site 479431011286 ligand binding site [chemical binding]; other site 479431011287 putative active site [active] 479431011288 NAD(P) binding site [chemical binding]; other site 479431011289 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479431011290 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479431011291 active site 479431011292 metal binding site [ion binding]; metal-binding site 479431011293 Cupin domain; Region: Cupin_2; cl17218 479431011294 hypothetical protein; Provisional; Region: PRK10621 479431011295 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479431011296 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 479431011297 nudix motif; other site 479431011298 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479431011299 PAS domain; Region: PAS_9; pfam13426 479431011300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479431011301 putative active site [active] 479431011302 heme pocket [chemical binding]; other site 479431011303 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 479431011304 putative active site [active] 479431011305 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 479431011306 GTP-binding protein YchF; Reviewed; Region: PRK09601 479431011307 YchF GTPase; Region: YchF; cd01900 479431011308 G1 box; other site 479431011309 GTP/Mg2+ binding site [chemical binding]; other site 479431011310 Switch I region; other site 479431011311 G2 box; other site 479431011312 Switch II region; other site 479431011313 G3 box; other site 479431011314 G4 box; other site 479431011315 G5 box; other site 479431011316 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 479431011317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431011318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431011319 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 479431011320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431011321 S-adenosylmethionine binding site [chemical binding]; other site 479431011322 AlkA N-terminal domain; Region: AlkA_N; pfam06029 479431011323 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 479431011324 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 479431011325 minor groove reading motif; other site 479431011326 helix-hairpin-helix signature motif; other site 479431011327 substrate binding pocket [chemical binding]; other site 479431011328 active site 479431011329 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 479431011330 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 479431011331 putative active site [active] 479431011332 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 479431011333 putative active site [active] 479431011334 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 479431011335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431011336 dimer interface [polypeptide binding]; other site 479431011337 conserved gate region; other site 479431011338 putative PBP binding loops; other site 479431011339 ABC-ATPase subunit interface; other site 479431011340 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 479431011341 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 479431011342 Walker A/P-loop; other site 479431011343 ATP binding site [chemical binding]; other site 479431011344 Q-loop/lid; other site 479431011345 ABC transporter signature motif; other site 479431011346 Walker B; other site 479431011347 D-loop; other site 479431011348 H-loop/switch region; other site 479431011349 NMT1-like family; Region: NMT1_2; pfam13379 479431011350 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 479431011351 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 479431011352 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 479431011353 CysD dimerization site [polypeptide binding]; other site 479431011354 G1 box; other site 479431011355 putative GEF interaction site [polypeptide binding]; other site 479431011356 GTP/Mg2+ binding site [chemical binding]; other site 479431011357 Switch I region; other site 479431011358 G2 box; other site 479431011359 G3 box; other site 479431011360 Switch II region; other site 479431011361 G4 box; other site 479431011362 G5 box; other site 479431011363 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 479431011364 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 479431011365 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 479431011366 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 479431011367 Active Sites [active] 479431011368 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 479431011369 ligand-binding site [chemical binding]; other site 479431011370 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 479431011371 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 479431011372 Active Sites [active] 479431011373 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 479431011374 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 479431011375 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479431011376 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479431011377 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479431011378 active site 479431011379 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479431011380 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479431011381 active site 479431011382 catalytic tetrad [active] 479431011383 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 479431011384 RmuC family; Region: RmuC; pfam02646 479431011385 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 479431011386 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 479431011387 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 479431011388 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 479431011389 generic binding surface II; other site 479431011390 generic binding surface I; other site 479431011391 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 479431011392 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 479431011393 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 479431011394 tetramerization interface [polypeptide binding]; other site 479431011395 active site 479431011396 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 479431011397 classical (c) SDRs; Region: SDR_c; cd05233 479431011398 NAD(P) binding site [chemical binding]; other site 479431011399 active site 479431011400 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 479431011401 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 479431011402 DAK2 domain; Region: Dak2; cl03685 479431011403 hypothetical protein; Provisional; Region: PRK07945 479431011404 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 479431011405 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 479431011406 active site 479431011407 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 479431011408 fumarate hydratase; Reviewed; Region: fumC; PRK00485 479431011409 Class II fumarases; Region: Fumarase_classII; cd01362 479431011410 active site 479431011411 tetramer interface [polypeptide binding]; other site 479431011412 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431011413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431011414 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431011415 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431011416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431011417 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431011418 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479431011419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431011420 S-adenosylmethionine binding site [chemical binding]; other site 479431011421 Escherichia coli YdjC-like family of proteins; Region: YdjC; cd10808 479431011422 putative active site [active] 479431011423 YdjC motif; other site 479431011424 Mg binding site [ion binding]; other site 479431011425 putative homodimer interface [polypeptide binding]; other site 479431011426 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479431011427 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 479431011428 Ligand binding site; other site 479431011429 Putative Catalytic site; other site 479431011430 DXD motif; other site 479431011431 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 479431011432 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 479431011433 putative active site [active] 479431011434 PhoH-like protein; Region: PhoH; pfam02562 479431011435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431011436 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479431011437 dimerization interface [polypeptide binding]; other site 479431011438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431011439 dimer interface [polypeptide binding]; other site 479431011440 phosphorylation site [posttranslational modification] 479431011441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431011442 ATP binding site [chemical binding]; other site 479431011443 Mg2+ binding site [ion binding]; other site 479431011444 G-X-G motif; other site 479431011445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431011446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431011447 active site 479431011448 phosphorylation site [posttranslational modification] 479431011449 intermolecular recognition site; other site 479431011450 dimerization interface [polypeptide binding]; other site 479431011451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431011452 DNA binding site [nucleotide binding] 479431011453 camphor resistance protein CrcB; Provisional; Region: PRK14216 479431011454 camphor resistance protein CrcB; Provisional; Region: PRK14228 479431011455 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 479431011456 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 479431011457 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 479431011458 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 479431011459 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 479431011460 catalytic residue [active] 479431011461 putative FPP diphosphate binding site; other site 479431011462 putative FPP binding hydrophobic cleft; other site 479431011463 dimer interface [polypeptide binding]; other site 479431011464 putative IPP diphosphate binding site; other site 479431011465 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 479431011466 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 479431011467 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479431011468 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 479431011469 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 479431011470 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 479431011471 threonine dehydratase; Provisional; Region: PRK08198 479431011472 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479431011473 tetramer interface [polypeptide binding]; other site 479431011474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431011475 catalytic residue [active] 479431011476 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 479431011477 cystathionine gamma-synthase; Provisional; Region: PRK07811 479431011478 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 479431011479 homodimer interface [polypeptide binding]; other site 479431011480 substrate-cofactor binding pocket; other site 479431011481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431011482 catalytic residue [active] 479431011483 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 479431011484 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 479431011485 dimer interface [polypeptide binding]; other site 479431011486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431011487 catalytic residue [active] 479431011488 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 479431011489 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 479431011490 active site 479431011491 catalytic triad [active] 479431011492 oxyanion hole [active] 479431011493 Bax inhibitor 1 like; Region: BaxI_1; cl17691 479431011494 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 479431011495 exopolyphosphatase; Region: exo_poly_only; TIGR03706 479431011496 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 479431011497 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431011498 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479431011499 active site 479431011500 Proteins of 100 residues with WXG; Region: WXG100; cl02005 479431011501 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 479431011502 Septum formation initiator; Region: DivIC; pfam04977 479431011503 enolase; Provisional; Region: eno; PRK00077 479431011504 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 479431011505 dimer interface [polypeptide binding]; other site 479431011506 metal binding site [ion binding]; metal-binding site 479431011507 substrate binding pocket [chemical binding]; other site 479431011508 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 479431011509 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 479431011510 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 479431011511 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 479431011512 homodimer interface [polypeptide binding]; other site 479431011513 substrate-cofactor binding pocket; other site 479431011514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431011515 catalytic residue [active] 479431011516 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 479431011517 active site 479431011518 catalytic residues [active] 479431011519 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 479431011520 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 479431011521 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479431011522 DNA binding site [nucleotide binding] 479431011523 active site 479431011524 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479431011525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431011526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431011527 DNA binding residues [nucleotide binding] 479431011528 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479431011529 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431011530 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 479431011531 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 479431011532 homodimer interface [polypeptide binding]; other site 479431011533 metal binding site [ion binding]; metal-binding site 479431011534 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 479431011535 Bacterial sugar transferase; Region: Bac_transf; pfam02397 479431011536 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431011537 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 479431011538 active site 479431011539 nucleotide binding site [chemical binding]; other site 479431011540 HIGH motif; other site 479431011541 KMSKS motif; other site 479431011542 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 479431011543 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431011544 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 479431011545 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 479431011546 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 479431011547 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 479431011548 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 479431011549 Chain length determinant protein; Region: Wzz; cl15801 479431011550 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 479431011551 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479431011552 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431011553 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479431011554 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479431011555 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 479431011556 Probable Catalytic site; other site 479431011557 metal-binding site 479431011558 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 479431011559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479431011560 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479431011561 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431011562 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431011563 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 479431011564 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 479431011565 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 479431011566 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 479431011567 FOG: PKD repeat [General function prediction only]; Region: COG3291 479431011568 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479431011569 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479431011570 Right handed beta helix region; Region: Beta_helix; pfam13229 479431011571 Right handed beta helix region; Region: Beta_helix; pfam13229 479431011572 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 479431011573 PKC phosphorylation site [posttranslational modification]; other site 479431011574 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 479431011575 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 479431011576 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 479431011577 putative transposase OrfB; Reviewed; Region: PHA02517 479431011578 HTH-like domain; Region: HTH_21; pfam13276 479431011579 Integrase core domain; Region: rve; pfam00665 479431011580 Integrase core domain; Region: rve_3; cl15866 479431011581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 479431011582 Transposase; Region: HTH_Tnp_1; cl17663 479431011583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431011584 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431011585 non-specific DNA binding site [nucleotide binding]; other site 479431011586 salt bridge; other site 479431011587 sequence-specific DNA binding site [nucleotide binding]; other site 479431011588 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431011589 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 479431011590 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479431011591 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479431011592 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479431011593 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479431011594 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479431011595 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479431011596 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 479431011597 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 479431011598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431011599 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431011600 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 479431011601 DNA-binding interface [nucleotide binding]; DNA binding site 479431011602 HTH-like domain; Region: HTH_21; pfam13276 479431011603 Integrase core domain; Region: rve; pfam00665 479431011604 Integrase core domain; Region: rve_3; pfam13683 479431011605 NAD synthetase; Reviewed; Region: nadE; PRK00876 479431011606 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 479431011607 Ligand Binding Site [chemical binding]; other site 479431011608 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 479431011609 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 479431011610 active site 479431011611 dimer interface [polypeptide binding]; other site 479431011612 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 479431011613 Ligand Binding Site [chemical binding]; other site 479431011614 Molecular Tunnel; other site 479431011615 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 479431011616 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 479431011617 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 479431011618 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431011619 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 479431011620 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 479431011621 Ligand Binding Site [chemical binding]; other site 479431011622 Molecular Tunnel; other site 479431011623 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 479431011624 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 479431011625 Probable Catalytic site; other site 479431011626 metal-binding site 479431011627 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 479431011628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479431011629 active site 479431011630 DDE superfamily endonuclease; Region: DDE_5; pfam13546 479431011631 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479431011632 active site 479431011633 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 479431011634 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 479431011635 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479431011636 active site 479431011637 catalytic residues [active] 479431011638 DNA binding site [nucleotide binding] 479431011639 Int/Topo IB signature motif; other site 479431011640 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 479431011641 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 479431011642 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 479431011643 trimer interface [polypeptide binding]; other site 479431011644 active site 479431011645 substrate binding site [chemical binding]; other site 479431011646 CoA binding site [chemical binding]; other site 479431011647 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 479431011648 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431011649 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431011650 acyl-activating enzyme (AAE) consensus motif; other site 479431011651 acyl-activating enzyme (AAE) consensus motif; other site 479431011652 AMP binding site [chemical binding]; other site 479431011653 active site 479431011654 CoA binding site [chemical binding]; other site 479431011655 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 479431011656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431011657 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 479431011658 Walker A/P-loop; other site 479431011659 ATP binding site [chemical binding]; other site 479431011660 Q-loop/lid; other site 479431011661 ABC transporter signature motif; other site 479431011662 Walker B; other site 479431011663 D-loop; other site 479431011664 H-loop/switch region; other site 479431011665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431011666 Walker A/P-loop; other site 479431011667 ATP binding site [chemical binding]; other site 479431011668 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 479431011669 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 479431011670 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 479431011671 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479431011672 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 479431011673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431011674 transposase/IS protein; Provisional; Region: PRK09183 479431011675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431011676 Walker A motif; other site 479431011677 ATP binding site [chemical binding]; other site 479431011678 Walker B motif; other site 479431011679 AAA domain; Region: AAA_22; pfam13401 479431011680 AAA ATPase domain; Region: AAA_16; pfam13191 479431011681 Walker A motif; other site 479431011682 ATP binding site [chemical binding]; other site 479431011683 Walker B motif; other site 479431011684 arginine finger; other site 479431011685 Helix-turn-helix domain; Region: HTH_28; pfam13518 479431011686 Winged helix-turn helix; Region: HTH_29; pfam13551 479431011687 Homeodomain-like domain; Region: HTH_32; pfam13565 479431011688 Integrase core domain; Region: rve; pfam00665 479431011689 Integrase core domain; Region: rve_3; cl15866 479431011690 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 479431011691 AAA ATPase domain; Region: AAA_16; pfam13191 479431011692 Archaeal ATPase; Region: Arch_ATPase; pfam01637 479431011693 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 479431011694 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 479431011695 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 479431011696 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431011697 ATP binding site [chemical binding]; other site 479431011698 putative Mg++ binding site [ion binding]; other site 479431011699 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431011700 nucleotide binding region [chemical binding]; other site 479431011701 ATP-binding site [chemical binding]; other site 479431011702 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 479431011703 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 479431011704 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 479431011705 Substrate binding site; other site 479431011706 Mg++ binding site; other site 479431011707 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 479431011708 active site 479431011709 substrate binding site [chemical binding]; other site 479431011710 CoA binding site [chemical binding]; other site 479431011711 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 479431011712 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 479431011713 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479431011714 active site 479431011715 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 479431011716 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 479431011717 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 479431011718 tetramer interface [polypeptide binding]; other site 479431011719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431011720 catalytic residue [active] 479431011721 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479431011722 Peptidase family M23; Region: Peptidase_M23; pfam01551 479431011723 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479431011724 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431011725 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479431011726 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 479431011727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431011728 Walker A/P-loop; other site 479431011729 ATP binding site [chemical binding]; other site 479431011730 Q-loop/lid; other site 479431011731 ABC transporter signature motif; other site 479431011732 Walker B; other site 479431011733 D-loop; other site 479431011734 H-loop/switch region; other site 479431011735 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479431011736 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479431011737 TM-ABC transporter signature motif; other site 479431011738 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 479431011739 putative ligand binding site [chemical binding]; other site 479431011740 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 479431011741 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 479431011742 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 479431011743 tetrameric interface [polypeptide binding]; other site 479431011744 NAD binding site [chemical binding]; other site 479431011745 catalytic residues [active] 479431011746 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 479431011747 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479431011748 PYR/PP interface [polypeptide binding]; other site 479431011749 dimer interface [polypeptide binding]; other site 479431011750 TPP binding site [chemical binding]; other site 479431011751 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479431011752 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 479431011753 TPP-binding site; other site 479431011754 KduI/IolB family; Region: KduI; pfam04962 479431011755 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 479431011756 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431011757 substrate binding site [chemical binding]; other site 479431011758 ATP binding site [chemical binding]; other site 479431011759 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479431011760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431011761 DNA-binding site [nucleotide binding]; DNA binding site 479431011762 UTRA domain; Region: UTRA; pfam07702 479431011763 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479431011764 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479431011765 NAD(P) binding site [chemical binding]; other site 479431011766 catalytic residues [active] 479431011767 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 479431011768 CoA-transferase family III; Region: CoA_transf_3; pfam02515 479431011769 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431011770 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431011771 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431011772 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479431011773 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431011774 active site 479431011775 metal binding site [ion binding]; metal-binding site 479431011776 AAA ATPase domain; Region: AAA_16; pfam13191 479431011777 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 479431011778 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 479431011779 5S rRNA interface [nucleotide binding]; other site 479431011780 CTC domain interface [polypeptide binding]; other site 479431011781 L16 interface [polypeptide binding]; other site 479431011782 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 479431011783 putative active site [active] 479431011784 catalytic residue [active] 479431011785 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 479431011786 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 479431011787 acyl-activating enzyme (AAE) consensus motif; other site 479431011788 active site 479431011789 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479431011790 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479431011791 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479431011792 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479431011793 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 479431011794 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 479431011795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431011796 S-adenosylmethionine binding site [chemical binding]; other site 479431011797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 479431011798 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479431011799 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479431011800 G5 domain; Region: G5; pfam07501 479431011801 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 479431011802 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479431011803 catalytic residue [active] 479431011804 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479431011805 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479431011806 G5 domain; Region: G5; pfam07501 479431011807 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 479431011808 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479431011809 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479431011810 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479431011811 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479431011812 G5 domain; Region: G5; pfam07501 479431011813 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 479431011814 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 479431011815 active site 479431011816 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 479431011817 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 479431011818 active site 479431011819 HIGH motif; other site 479431011820 KMSKS motif; other site 479431011821 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 479431011822 tRNA binding surface [nucleotide binding]; other site 479431011823 anticodon binding site; other site 479431011824 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479431011825 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 479431011826 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 479431011827 Yqey-like protein; Region: YqeY; cl17540 479431011828 Predicted methyltransferases [General function prediction only]; Region: COG0313 479431011829 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 479431011830 putative SAM binding site [chemical binding]; other site 479431011831 putative homodimer interface [polypeptide binding]; other site 479431011832 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 479431011833 Protein of unknown function DUF72; Region: DUF72; pfam01904 479431011834 Domain of unknown function DUF77; Region: DUF77; pfam01910 479431011835 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 479431011836 Cation efflux family; Region: Cation_efflux; pfam01545 479431011837 Uncharacterized conserved protein [Function unknown]; Region: COG2308 479431011838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 479431011839 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 479431011840 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 479431011841 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 479431011842 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 479431011843 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 479431011844 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 479431011845 acyl-activating enzyme (AAE) consensus motif; other site 479431011846 putative AMP binding site [chemical binding]; other site 479431011847 putative active site [active] 479431011848 putative CoA binding site [chemical binding]; other site 479431011849 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 479431011850 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 479431011851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 479431011852 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479431011853 ADDz for ATRX, Dnmt3 and Dnmt3l PHD-like zinc finger domain; Region: ADDz; cl17040 479431011854 Protein of unknown function (DUF998); Region: DUF998; pfam06197 479431011855 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 479431011856 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 479431011857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431011858 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479431011859 NAD(P) binding site [chemical binding]; other site 479431011860 active site 479431011861 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 479431011862 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479431011863 inhibitor-cofactor binding pocket; inhibition site 479431011864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431011865 catalytic residue [active] 479431011866 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 479431011867 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479431011868 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 479431011869 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431011870 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479431011871 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 479431011872 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431011873 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431011874 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 479431011875 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 479431011876 active site 479431011877 DNA binding site [nucleotide binding] 479431011878 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 479431011879 DNA binding site [nucleotide binding] 479431011880 Protein of unknown function (DUF419); Region: DUF419; pfam04237 479431011881 Response regulator receiver domain; Region: Response_reg; pfam00072 479431011882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431011883 active site 479431011884 phosphorylation site [posttranslational modification] 479431011885 intermolecular recognition site; other site 479431011886 dimerization interface [polypeptide binding]; other site 479431011887 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479431011888 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 479431011889 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 479431011890 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479431011891 ligand binding site [chemical binding]; other site 479431011892 flexible hinge region; other site 479431011893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431011894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431011895 ATP binding site [chemical binding]; other site 479431011896 Mg2+ binding site [ion binding]; other site 479431011897 G-X-G motif; other site 479431011898 Predicted dehydrogenase [General function prediction only]; Region: COG0579 479431011899 hydroxyglutarate oxidase; Provisional; Region: PRK11728 479431011900 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 479431011901 Uncharacterized conserved protein [Function unknown]; Region: COG2966 479431011902 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 479431011903 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 479431011904 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479431011905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431011906 S-adenosylmethionine binding site [chemical binding]; other site 479431011907 Peptidase M35 family; Region: M35_like; cl03449 479431011908 active site 479431011909 Zn binding site [ion binding]; other site 479431011910 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 479431011911 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 479431011912 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479431011913 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479431011914 active site 479431011915 catalytic tetrad [active] 479431011916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431011917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431011918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479431011919 dimerization interface [polypeptide binding]; other site 479431011920 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 479431011921 gating phenylalanine in ion channel; other site 479431011922 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479431011923 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479431011924 Walker A/P-loop; other site 479431011925 ATP binding site [chemical binding]; other site 479431011926 Q-loop/lid; other site 479431011927 ABC transporter signature motif; other site 479431011928 Walker B; other site 479431011929 D-loop; other site 479431011930 H-loop/switch region; other site 479431011931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431011932 Histidine kinase; Region: HisKA_3; pfam07730 479431011933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431011934 ATP binding site [chemical binding]; other site 479431011935 Mg2+ binding site [ion binding]; other site 479431011936 G-X-G motif; other site 479431011937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431011938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431011939 active site 479431011940 phosphorylation site [posttranslational modification] 479431011941 intermolecular recognition site; other site 479431011942 dimerization interface [polypeptide binding]; other site 479431011943 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431011944 DNA binding residues [nucleotide binding] 479431011945 dimerization interface [polypeptide binding]; other site 479431011946 adenosine deaminase; Provisional; Region: PRK09358 479431011947 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 479431011948 active site 479431011949 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 479431011950 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431011951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431011952 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 479431011953 putative dimerization interface [polypeptide binding]; other site 479431011954 SnoaL-like domain; Region: SnoaL_2; pfam12680 479431011955 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 479431011956 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 479431011957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431011958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431011959 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 479431011960 Prostaglandin dehydrogenases; Region: PGDH; cd05288 479431011961 NAD(P) binding site [chemical binding]; other site 479431011962 substrate binding site [chemical binding]; other site 479431011963 dimer interface [polypeptide binding]; other site 479431011964 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 479431011965 RibD C-terminal domain; Region: RibD_C; cl17279 479431011966 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 479431011967 AAA domain; Region: AAA_11; pfam13086 479431011968 Part of AAA domain; Region: AAA_19; pfam13245 479431011969 Family description; Region: UvrD_C_2; pfam13538 479431011970 AAA domain; Region: AAA_21; pfam13304 479431011971 Protein of unknown function DUF45; Region: DUF45; pfam01863 479431011972 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 479431011973 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 479431011974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431011975 ATP binding site [chemical binding]; other site 479431011976 putative Mg++ binding site [ion binding]; other site 479431011977 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 479431011978 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 479431011979 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 479431011980 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 479431011981 HsdM N-terminal domain; Region: HsdM_N; pfam12161 479431011982 Methyltransferase domain; Region: Methyltransf_26; pfam13659 479431011983 AAA domain; Region: AAA_22; pfam13401 479431011984 MT-A70; Region: MT-A70; cl01947 479431011985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431011986 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431011987 Replication-relaxation; Region: Replic_Relax; pfam13814 479431011988 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 479431011989 DNA methylase; Region: N6_N4_Mtase; pfam01555 479431011990 Antirestriction protein (ArdA); Region: ArdA; cl01953 479431011991 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431011992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431011993 non-specific DNA binding site [nucleotide binding]; other site 479431011994 salt bridge; other site 479431011995 sequence-specific DNA binding site [nucleotide binding]; other site 479431011996 Plasmodium RESA N-terminal; Region: PRESAN; cl12122 479431011997 Domain of unknown function (DUF955); Region: DUF955; pfam06114 479431011998 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 479431011999 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479431012000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479431012001 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 479431012002 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 479431012003 dimer interface [polypeptide binding]; other site 479431012004 putative functional site; other site 479431012005 putative MPT binding site; other site 479431012006 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 479431012007 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 479431012008 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 479431012009 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 479431012010 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 479431012011 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 479431012012 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 479431012013 MPT binding site; other site 479431012014 trimer interface [polypeptide binding]; other site 479431012015 BioY family; Region: BioY; pfam02632 479431012016 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431012017 AMP binding site [chemical binding]; other site 479431012018 active site 479431012019 acyl-activating enzyme (AAE) consensus motif; other site 479431012020 CoA binding site [chemical binding]; other site 479431012021 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479431012022 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 479431012023 dimer interface [polypeptide binding]; other site 479431012024 active site 479431012025 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 479431012026 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 479431012027 Walker A/P-loop; other site 479431012028 ATP binding site [chemical binding]; other site 479431012029 Q-loop/lid; other site 479431012030 ABC transporter signature motif; other site 479431012031 Walker B; other site 479431012032 D-loop; other site 479431012033 H-loop/switch region; other site 479431012034 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431012035 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431012036 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 479431012037 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 479431012038 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 479431012039 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 479431012040 active site 479431012041 putative catalytic site [active] 479431012042 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 479431012043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431012044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431012045 DNA binding residues [nucleotide binding] 479431012046 Anti-sigma-K factor rskA; Region: RskA; pfam10099 479431012047 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 479431012048 putative ADP-ribose binding site [chemical binding]; other site 479431012049 putative active site [active] 479431012050 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479431012051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431012052 motif I; other site 479431012053 active site 479431012054 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479431012055 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 479431012056 NADP binding site [chemical binding]; other site 479431012057 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 479431012058 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479431012059 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 479431012060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431012061 non-specific DNA binding site [nucleotide binding]; other site 479431012062 salt bridge; other site 479431012063 sequence-specific DNA binding site [nucleotide binding]; other site 479431012064 Cupin domain; Region: Cupin_2; pfam07883 479431012065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431012066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431012067 active site 479431012068 phosphorylation site [posttranslational modification] 479431012069 intermolecular recognition site; other site 479431012070 dimerization interface [polypeptide binding]; other site 479431012071 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431012072 DNA binding site [nucleotide binding] 479431012073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431012074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431012075 dimer interface [polypeptide binding]; other site 479431012076 phosphorylation site [posttranslational modification] 479431012077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431012078 ATP binding site [chemical binding]; other site 479431012079 G-X-G motif; other site 479431012080 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 479431012081 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 479431012082 active site 479431012083 dimer interface [polypeptide binding]; other site 479431012084 metal binding site [ion binding]; metal-binding site 479431012085 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 479431012086 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 479431012087 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 479431012088 Serine hydrolase; Region: Ser_hydrolase; pfam06821 479431012089 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431012090 heat shock protein 90; Provisional; Region: PRK05218 479431012091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479431012092 ATP binding site [chemical binding]; other site 479431012093 Mg2+ binding site [ion binding]; other site 479431012094 G-X-G motif; other site 479431012095 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 479431012096 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 479431012097 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431012098 Ligand Binding Site [chemical binding]; other site 479431012099 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431012100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431012101 DNA binding site [nucleotide binding] 479431012102 domain linker motif; other site 479431012103 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479431012104 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431012105 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 479431012106 homodimer interface [polypeptide binding]; other site 479431012107 maltodextrin glucosidase; Provisional; Region: PRK10785 479431012108 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 479431012109 active site 479431012110 homodimer interface [polypeptide binding]; other site 479431012111 catalytic site [active] 479431012112 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 479431012113 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 479431012114 Walker A/P-loop; other site 479431012115 ATP binding site [chemical binding]; other site 479431012116 Q-loop/lid; other site 479431012117 ABC transporter signature motif; other site 479431012118 Walker B; other site 479431012119 D-loop; other site 479431012120 H-loop/switch region; other site 479431012121 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479431012122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 479431012123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431012124 dimer interface [polypeptide binding]; other site 479431012125 conserved gate region; other site 479431012126 putative PBP binding loops; other site 479431012127 ABC-ATPase subunit interface; other site 479431012128 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479431012129 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479431012130 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 479431012131 iron-sulfur cluster [ion binding]; other site 479431012132 [2Fe-2S] cluster binding site [ion binding]; other site 479431012133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431012134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431012135 active site 479431012136 phosphorylation site [posttranslational modification] 479431012137 intermolecular recognition site; other site 479431012138 dimerization interface [polypeptide binding]; other site 479431012139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431012140 DNA binding site [nucleotide binding] 479431012141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431012142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479431012143 dimerization interface [polypeptide binding]; other site 479431012144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431012145 dimer interface [polypeptide binding]; other site 479431012146 phosphorylation site [posttranslational modification] 479431012147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431012148 ATP binding site [chemical binding]; other site 479431012149 Mg2+ binding site [ion binding]; other site 479431012150 G-X-G motif; other site 479431012151 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 479431012152 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479431012153 helix-hairpin-helix signature motif; other site 479431012154 substrate binding pocket [chemical binding]; other site 479431012155 active site 479431012156 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479431012157 Predicted ATPase [General function prediction only]; Region: COG3903 479431012158 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 479431012159 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 479431012160 Ligand binding site; other site 479431012161 Ligand binding site; other site 479431012162 Ligand binding site; other site 479431012163 Putative Catalytic site; other site 479431012164 DXD motif; other site 479431012165 GtrA-like protein; Region: GtrA; pfam04138 479431012166 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 479431012167 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 479431012168 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479431012169 DNA binding residues [nucleotide binding] 479431012170 dimer interface [polypeptide binding]; other site 479431012171 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 479431012172 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 479431012173 NodB motif; other site 479431012174 putative active site [active] 479431012175 putative catalytic site [active] 479431012176 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479431012177 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 479431012178 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 479431012179 acyl-activating enzyme (AAE) consensus motif; other site 479431012180 putative AMP binding site [chemical binding]; other site 479431012181 putative active site [active] 479431012182 putative CoA binding site [chemical binding]; other site 479431012183 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 479431012184 dimer interface [polypeptide binding]; other site 479431012185 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 479431012186 active site 479431012187 citrylCoA binding site [chemical binding]; other site 479431012188 NADH binding [chemical binding]; other site 479431012189 cationic pore residues; other site 479431012190 oxalacetate/citrate binding site [chemical binding]; other site 479431012191 coenzyme A binding site [chemical binding]; other site 479431012192 catalytic triad [active] 479431012193 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 479431012194 DNA photolyase; Region: DNA_photolyase; pfam00875 479431012195 enterobactin exporter EntS; Provisional; Region: PRK10489 479431012196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431012197 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 479431012198 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 479431012199 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 479431012200 citrate synthase 2; Provisional; Region: PRK12350 479431012201 Citrate synthase; Region: Citrate_synt; pfam00285 479431012202 oxalacetate binding site [chemical binding]; other site 479431012203 citrylCoA binding site [chemical binding]; other site 479431012204 coenzyme A binding site [chemical binding]; other site 479431012205 catalytic triad [active] 479431012206 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479431012207 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431012208 catalytic residue [active] 479431012209 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 479431012210 Predicted integral membrane protein [Function unknown]; Region: COG5542 479431012211 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479431012212 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479431012213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431012214 Walker A/P-loop; other site 479431012215 ATP binding site [chemical binding]; other site 479431012216 Q-loop/lid; other site 479431012217 ABC transporter signature motif; other site 479431012218 Walker B; other site 479431012219 D-loop; other site 479431012220 H-loop/switch region; other site 479431012221 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479431012222 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479431012223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431012224 Walker A/P-loop; other site 479431012225 ATP binding site [chemical binding]; other site 479431012226 Q-loop/lid; other site 479431012227 ABC transporter signature motif; other site 479431012228 Walker B; other site 479431012229 D-loop; other site 479431012230 H-loop/switch region; other site 479431012231 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431012232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431012233 DNA binding residues [nucleotide binding] 479431012234 dimerization interface [polypeptide binding]; other site 479431012235 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 479431012236 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 479431012237 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431012238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431012239 non-specific DNA binding site [nucleotide binding]; other site 479431012240 salt bridge; other site 479431012241 sequence-specific DNA binding site [nucleotide binding]; other site 479431012242 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 479431012243 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 479431012244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431012245 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479431012246 NAD(P) binding site [chemical binding]; other site 479431012247 active site 479431012248 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479431012249 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 479431012250 active site 479431012251 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479431012252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431012253 NAD(P) binding site [chemical binding]; other site 479431012254 active site 479431012255 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431012256 MarR family; Region: MarR; pfam01047 479431012257 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 479431012258 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 479431012259 H+ Antiporter protein; Region: 2A0121; TIGR00900 479431012260 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 479431012261 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 479431012262 DNA-binding site [nucleotide binding]; DNA binding site 479431012263 RNA-binding motif; other site 479431012264 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431012265 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431012266 active site 479431012267 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479431012268 VanZ like family; Region: VanZ; pfam04892 479431012269 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 479431012270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431012271 active site 479431012272 motif I; other site 479431012273 motif II; other site 479431012274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479431012275 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479431012276 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 479431012277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431012278 Histidine kinase; Region: HisKA_3; pfam07730 479431012279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431012280 ATP binding site [chemical binding]; other site 479431012281 Mg2+ binding site [ion binding]; other site 479431012282 G-X-G motif; other site 479431012283 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431012284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431012285 active site 479431012286 phosphorylation site [posttranslational modification] 479431012287 intermolecular recognition site; other site 479431012288 dimerization interface [polypeptide binding]; other site 479431012289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431012290 DNA binding residues [nucleotide binding] 479431012291 dimerization interface [polypeptide binding]; other site 479431012292 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431012293 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479431012294 Short C-terminal domain; Region: SHOCT; pfam09851 479431012295 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431012296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431012297 DNA binding residues [nucleotide binding] 479431012298 dimerization interface [polypeptide binding]; other site 479431012299 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 479431012300 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 479431012301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 479431012302 Transposase domain (DUF772); Region: DUF772; pfam05598 479431012303 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431012304 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431012305 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431012306 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 479431012307 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431012308 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 479431012309 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 479431012310 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 479431012311 XdhC Rossmann domain; Region: XdhC_C; pfam13478 479431012312 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 479431012313 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479431012314 FeS/SAM binding site; other site 479431012315 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 479431012316 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 479431012317 MoaE interaction surface [polypeptide binding]; other site 479431012318 MoeB interaction surface [polypeptide binding]; other site 479431012319 thiocarboxylated glycine; other site 479431012320 HEAT repeats; Region: HEAT_2; pfam13646 479431012321 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431012322 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479431012323 Walker A/P-loop; other site 479431012324 ATP binding site [chemical binding]; other site 479431012325 Q-loop/lid; other site 479431012326 ABC transporter signature motif; other site 479431012327 Walker B; other site 479431012328 D-loop; other site 479431012329 H-loop/switch region; other site 479431012330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431012331 DNA-binding site [nucleotide binding]; DNA binding site 479431012332 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 479431012333 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 479431012334 putative active site [active] 479431012335 putative catalytic site [active] 479431012336 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479431012337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479431012338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431012339 Walker A/P-loop; other site 479431012340 ATP binding site [chemical binding]; other site 479431012341 Q-loop/lid; other site 479431012342 ABC transporter signature motif; other site 479431012343 Walker B; other site 479431012344 D-loop; other site 479431012345 H-loop/switch region; other site 479431012346 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479431012347 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 479431012348 Predicted acetyltransferase [General function prediction only]; Region: COG2388 479431012349 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 479431012350 MoaE homodimer interface [polypeptide binding]; other site 479431012351 MoaD interaction [polypeptide binding]; other site 479431012352 active site residues [active] 479431012353 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431012354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431012355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431012356 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431012357 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 479431012358 MPT binding site; other site 479431012359 trimer interface [polypeptide binding]; other site 479431012360 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 479431012361 trimer interface [polypeptide binding]; other site 479431012362 dimer interface [polypeptide binding]; other site 479431012363 putative active site [active] 479431012364 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431012365 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431012366 DNA binding site [nucleotide binding] 479431012367 domain linker motif; other site 479431012368 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431012369 ligand binding site [chemical binding]; other site 479431012370 dimerization interface [polypeptide binding]; other site 479431012371 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 479431012372 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 479431012373 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 479431012374 active site 479431012375 P-loop; other site 479431012376 phosphorylation site [posttranslational modification] 479431012377 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 479431012378 active site 479431012379 phosphorylation site [posttranslational modification] 479431012380 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 479431012381 metal-binding site 479431012382 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 479431012383 WYL domain; Region: WYL; pfam13280 479431012384 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 479431012385 Helix-turn-helix domain; Region: HTH_38; pfam13936 479431012386 Integrase core domain; Region: rve; pfam00665 479431012387 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 479431012388 active site 2 [active] 479431012389 active site 1 [active] 479431012390 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479431012391 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479431012392 active site 479431012393 catalytic tetrad [active] 479431012394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431012395 ATP binding site [chemical binding]; other site 479431012396 putative Mg++ binding site [ion binding]; other site 479431012397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431012398 nucleotide binding region [chemical binding]; other site 479431012399 ATP-binding site [chemical binding]; other site 479431012400 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 479431012401 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431012402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431012403 putative DNA binding site [nucleotide binding]; other site 479431012404 putative Zn2+ binding site [ion binding]; other site 479431012405 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431012406 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 479431012407 glycerate dehydrogenase; Provisional; Region: PRK06487 479431012408 NAD binding site [chemical binding]; other site 479431012409 ligand binding site [chemical binding]; other site 479431012410 catalytic site [active] 479431012411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431012412 metabolite-proton symporter; Region: 2A0106; TIGR00883 479431012413 putative substrate translocation pore; other site 479431012414 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 479431012415 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 479431012416 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 479431012417 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 479431012418 TPP-binding site [chemical binding]; other site 479431012419 dimer interface [polypeptide binding]; other site 479431012420 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 479431012421 PYR/PP interface [polypeptide binding]; other site 479431012422 dimer interface [polypeptide binding]; other site 479431012423 TPP binding site [chemical binding]; other site 479431012424 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479431012425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431012426 DNA-binding site [nucleotide binding]; DNA binding site 479431012427 FCD domain; Region: FCD; pfam07729 479431012428 GntP family permease; Region: GntP_permease; pfam02447 479431012429 fructuronate transporter; Provisional; Region: PRK10034; cl15264 479431012430 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 479431012431 AAA domain; Region: AAA_33; pfam13671 479431012432 ATP-binding site [chemical binding]; other site 479431012433 Gluconate-6-phosphate binding site [chemical binding]; other site 479431012434 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479431012435 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 479431012436 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 479431012437 Transcriptional regulator PadR-like family; Region: PadR; cl17335 479431012438 Predicted transcriptional regulators [Transcription]; Region: COG1695 479431012439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431012440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431012441 putative substrate translocation pore; other site 479431012442 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 479431012443 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 479431012444 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 479431012445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479431012446 ATP binding site [chemical binding]; other site 479431012447 putative Mg++ binding site [ion binding]; other site 479431012448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479431012449 nucleotide binding region [chemical binding]; other site 479431012450 ATP-binding site [chemical binding]; other site 479431012451 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 479431012452 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 479431012453 dimer interface [polypeptide binding]; other site 479431012454 PYR/PP interface [polypeptide binding]; other site 479431012455 TPP binding site [chemical binding]; other site 479431012456 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479431012457 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 479431012458 TPP-binding site [chemical binding]; other site 479431012459 dimer interface [polypeptide binding]; other site 479431012460 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479431012461 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479431012462 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431012463 catalytic residue [active] 479431012464 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479431012465 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479431012466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431012467 DNA-binding site [nucleotide binding]; DNA binding site 479431012468 FCD domain; Region: FCD; pfam07729 479431012469 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 479431012470 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 479431012471 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 479431012472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431012473 metabolite-proton symporter; Region: 2A0106; TIGR00883 479431012474 putative substrate translocation pore; other site 479431012475 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 479431012476 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479431012477 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431012478 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 479431012479 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 479431012480 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479431012481 putative NAD(P) binding site [chemical binding]; other site 479431012482 catalytic Zn binding site [ion binding]; other site 479431012483 structural Zn binding site [ion binding]; other site 479431012484 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 479431012485 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 479431012486 NAD binding site [chemical binding]; other site 479431012487 catalytic Zn binding site [ion binding]; other site 479431012488 structural Zn binding site [ion binding]; other site 479431012489 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479431012490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431012491 DNA-binding site [nucleotide binding]; DNA binding site 479431012492 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431012493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431012494 homodimer interface [polypeptide binding]; other site 479431012495 catalytic residue [active] 479431012496 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 479431012497 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479431012498 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 479431012499 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479431012500 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479431012501 Protein of unknown function (DUF690); Region: DUF690; cl04939 479431012502 Protein of unknown function (DUF690); Region: DUF690; cl04939 479431012503 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 479431012504 CGNR zinc finger; Region: zf-CGNR; pfam11706 479431012505 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 479431012506 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 479431012507 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479431012508 Protein of unknown function DUF58; Region: DUF58; pfam01882 479431012509 MoxR-like ATPases [General function prediction only]; Region: COG0714 479431012510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 479431012511 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479431012512 Interdomain contacts; other site 479431012513 Cytokine receptor motif; other site 479431012514 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479431012515 Interdomain contacts; other site 479431012516 Cytokine receptor motif; other site 479431012517 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479431012518 Interdomain contacts; other site 479431012519 Cytokine receptor motif; other site 479431012520 PspC domain; Region: PspC; pfam04024 479431012521 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 479431012522 active site 479431012523 phosphate binding residues; other site 479431012524 catalytic residues [active] 479431012525 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 479431012526 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479431012527 homodimer interface [polypeptide binding]; other site 479431012528 active site 479431012529 TDP-binding site; other site 479431012530 acceptor substrate-binding pocket; other site 479431012531 HEAT repeats; Region: HEAT_2; pfam13646 479431012532 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479431012533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431012534 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 479431012535 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 479431012536 active site 479431012537 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 479431012538 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 479431012539 ring oligomerisation interface [polypeptide binding]; other site 479431012540 ATP/Mg binding site [chemical binding]; other site 479431012541 stacking interactions; other site 479431012542 hinge regions; other site 479431012543 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479431012544 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479431012545 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 479431012546 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 479431012547 dimer interface [polypeptide binding]; other site 479431012548 putative functional site; other site 479431012549 putative MPT binding site; other site 479431012550 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479431012551 putative catalytic site [active] 479431012552 putative phosphate binding site [ion binding]; other site 479431012553 putative metal binding site [ion binding]; other site 479431012554 agmatinase; Region: agmatinase; TIGR01230 479431012555 Agmatinase-like family; Region: Agmatinase-like; cd09990 479431012556 active site 479431012557 oligomer interface [polypeptide binding]; other site 479431012558 Mn binding site [ion binding]; other site 479431012559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431012560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431012561 Integral membrane protein TerC family; Region: TerC; cl10468 479431012562 Predicted membrane protein [Function unknown]; Region: COG2261 479431012563 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 479431012564 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 479431012565 Uncharacterized conserved protein [Function unknown]; Region: COG4850 479431012566 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 479431012567 ethanolamine permease; Region: 2A0305; TIGR00908 479431012568 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 479431012569 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 479431012570 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 479431012571 PAS domain; Region: PAS_9; pfam13426 479431012572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479431012573 putative active site [active] 479431012574 heme pocket [chemical binding]; other site 479431012575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 479431012576 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 479431012577 Homeodomain-like domain; Region: HTH_23; pfam13384 479431012578 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479431012579 Integrase core domain; Region: rve; pfam00665 479431012580 Integrase core domain; Region: rve_3; pfam13683 479431012581 Predicted transcriptional regulators [Transcription]; Region: COG1733 479431012582 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479431012583 Transposase domain (DUF772); Region: DUF772; pfam05598 479431012584 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 479431012585 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 479431012586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431012587 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431012588 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431012589 Homeodomain-like domain; Region: HTH_23; cl17451 479431012590 Winged helix-turn helix; Region: HTH_29; pfam13551 479431012591 Integrase core domain; Region: rve; pfam00665 479431012592 Integrase core domain; Region: rve_3; pfam13683 479431012593 cyanophycin synthetase; Provisional; Region: PRK14016 479431012594 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431012595 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479431012596 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479431012597 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479431012598 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479431012599 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431012600 catalytic residue [active] 479431012601 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 479431012602 ABC1 family; Region: ABC1; cl17513 479431012603 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479431012604 active site 479431012605 ATP binding site [chemical binding]; other site 479431012606 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 479431012607 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 479431012608 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 479431012609 proposed catalytic triad [active] 479431012610 active site nucleophile [active] 479431012611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479431012612 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 479431012613 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 479431012614 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 479431012615 NAD binding site [chemical binding]; other site 479431012616 homodimer interface [polypeptide binding]; other site 479431012617 active site 479431012618 substrate binding site [chemical binding]; other site 479431012619 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 479431012620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431012621 putative substrate translocation pore; other site 479431012622 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479431012623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431012624 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 479431012625 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 479431012626 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 479431012627 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 479431012628 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 479431012629 amidase; Provisional; Region: PRK07486 479431012630 Amidase; Region: Amidase; cl11426 479431012631 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479431012632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431012633 AMP-binding domain protein; Validated; Region: PRK08315 479431012634 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431012635 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 479431012636 acyl-activating enzyme (AAE) consensus motif; other site 479431012637 putative AMP binding site [chemical binding]; other site 479431012638 putative active site [active] 479431012639 putative CoA binding site [chemical binding]; other site 479431012640 TIGR03084 family protein; Region: TIGR03084 479431012641 enoyl-CoA hydratase; Provisional; Region: PRK07827 479431012642 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479431012643 substrate binding site [chemical binding]; other site 479431012644 oxyanion hole (OAH) forming residues; other site 479431012645 trimer interface [polypeptide binding]; other site 479431012646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431012647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431012648 putative substrate translocation pore; other site 479431012649 Predicted transcriptional regulators [Transcription]; Region: COG1695 479431012650 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479431012651 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 479431012652 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 479431012653 PAS fold; Region: PAS_3; pfam08447 479431012654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431012655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431012656 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479431012657 classical (c) SDRs; Region: SDR_c; cd05233 479431012658 NAD(P) binding site [chemical binding]; other site 479431012659 active site 479431012660 acyl-CoA synthetase; Validated; Region: PRK06188 479431012661 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479431012662 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 479431012663 acyl-activating enzyme (AAE) consensus motif; other site 479431012664 acyl-activating enzyme (AAE) consensus motif; other site 479431012665 putative AMP binding site [chemical binding]; other site 479431012666 putative active site [active] 479431012667 putative CoA binding site [chemical binding]; other site 479431012668 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 479431012669 ThiS interaction site; other site 479431012670 putative active site [active] 479431012671 tetramer interface [polypeptide binding]; other site 479431012672 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 479431012673 thiS-thiF/thiG interaction site; other site 479431012674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431012675 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 479431012676 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 479431012677 active site 479431012678 thiamine phosphate binding site [chemical binding]; other site 479431012679 pyrophosphate binding site [ion binding]; other site 479431012680 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 479431012681 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 479431012682 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 479431012683 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 479431012684 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 479431012685 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 479431012686 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479431012687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431012688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431012689 DNA binding residues [nucleotide binding] 479431012690 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479431012691 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 479431012692 putative active site; other site 479431012693 putative metal binding residues [ion binding]; other site 479431012694 signature motif; other site 479431012695 putative triphosphate binding site [ion binding]; other site 479431012696 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 479431012697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431012698 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 479431012699 Walker A/P-loop; other site 479431012700 ATP binding site [chemical binding]; other site 479431012701 Q-loop/lid; other site 479431012702 ABC transporter signature motif; other site 479431012703 Walker B; other site 479431012704 D-loop; other site 479431012705 H-loop/switch region; other site 479431012706 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479431012707 GAF domain; Region: GAF; pfam01590 479431012708 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479431012709 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479431012710 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 479431012711 NAD(P) binding site [chemical binding]; other site 479431012712 catalytic residues [active] 479431012713 benzoate transport; Region: 2A0115; TIGR00895 479431012714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431012715 putative substrate translocation pore; other site 479431012716 hypothetical protein; Provisional; Region: PRK07236 479431012717 hypothetical protein; Provisional; Region: PRK06847 479431012718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479431012719 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 479431012720 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 479431012721 active site 479431012722 FMN binding site [chemical binding]; other site 479431012723 substrate binding site [chemical binding]; other site 479431012724 homotetramer interface [polypeptide binding]; other site 479431012725 catalytic residue [active] 479431012726 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 479431012727 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479431012728 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479431012729 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 479431012730 active site 479431012731 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 479431012732 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 479431012733 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 479431012734 VanW like protein; Region: VanW; pfam04294 479431012735 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479431012736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431012737 non-specific DNA binding site [nucleotide binding]; other site 479431012738 salt bridge; other site 479431012739 sequence-specific DNA binding site [nucleotide binding]; other site 479431012740 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 479431012741 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 479431012742 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 479431012743 Imelysin; Region: Peptidase_M75; pfam09375 479431012744 Iron permease FTR1 family; Region: FTR1; cl00475 479431012745 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 479431012746 active site 479431012747 catalytic residues [active] 479431012748 metal binding site [ion binding]; metal-binding site 479431012749 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 479431012750 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 479431012751 active site 479431012752 homotetramer interface [polypeptide binding]; other site 479431012753 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 479431012754 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 479431012755 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 479431012756 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 479431012757 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 479431012758 Domain of unknown function DUF20; Region: UPF0118; pfam01594 479431012759 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431012760 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431012761 DNA binding site [nucleotide binding] 479431012762 domain linker motif; other site 479431012763 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 479431012764 putative dimerization interface [polypeptide binding]; other site 479431012765 putative ligand binding site [chemical binding]; other site 479431012766 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 479431012767 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 479431012768 Walker A/P-loop; other site 479431012769 ATP binding site [chemical binding]; other site 479431012770 Q-loop/lid; other site 479431012771 ABC transporter signature motif; other site 479431012772 Walker B; other site 479431012773 D-loop; other site 479431012774 H-loop/switch region; other site 479431012775 TOBE domain; Region: TOBE_2; pfam08402 479431012776 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 479431012777 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 479431012778 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 479431012779 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 479431012780 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 479431012781 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479431012782 intersubunit interface [polypeptide binding]; other site 479431012783 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 479431012784 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 479431012785 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 479431012786 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 479431012787 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 479431012788 active site 479431012789 HIGH motif; other site 479431012790 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 479431012791 KMSKS motif; other site 479431012792 tRNA binding surface [nucleotide binding]; other site 479431012793 anticodon binding site; other site 479431012794 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 479431012795 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 479431012796 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 479431012797 Ca binding site [ion binding]; other site 479431012798 active site 479431012799 catalytic site [active] 479431012800 Lsr2; Region: Lsr2; pfam11774 479431012801 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479431012802 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 479431012803 AP (apurinic/apyrimidinic) site pocket; other site 479431012804 Metal-binding active site; metal-binding site 479431012805 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431012806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431012807 active site 479431012808 phosphorylation site [posttranslational modification] 479431012809 intermolecular recognition site; other site 479431012810 dimerization interface [polypeptide binding]; other site 479431012811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431012812 DNA binding site [nucleotide binding] 479431012813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431012814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431012815 dimer interface [polypeptide binding]; other site 479431012816 phosphorylation site [posttranslational modification] 479431012817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431012818 ATP binding site [chemical binding]; other site 479431012819 Mg2+ binding site [ion binding]; other site 479431012820 G-X-G motif; other site 479431012821 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431012822 catalytic core [active] 479431012823 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431012824 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 479431012825 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 479431012826 NlpC/P60 family; Region: NLPC_P60; cl17555 479431012827 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 479431012828 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 479431012829 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 479431012830 putative ADP-binding pocket [chemical binding]; other site 479431012831 Bacterial Ig-like domain; Region: Big_5; pfam13205 479431012832 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 479431012833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 479431012834 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479431012835 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 479431012836 FAD binding domain; Region: FAD_binding_4; pfam01565 479431012837 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 479431012838 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 479431012839 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 479431012840 tetrameric interface [polypeptide binding]; other site 479431012841 NAD binding site [chemical binding]; other site 479431012842 catalytic residues [active] 479431012843 substrate binding site [chemical binding]; other site 479431012844 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479431012845 Cytochrome P450; Region: p450; cl12078 479431012846 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 479431012847 active site residue [active] 479431012848 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479431012849 Transposase, Mutator family; Region: Transposase_mut; pfam00872 479431012850 MULE transposase domain; Region: MULE; pfam10551 479431012851 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 479431012852 AAA ATPase domain; Region: AAA_16; pfam13191 479431012853 Helix-turn-helix domain; Region: HTH_28; pfam13518 479431012854 Winged helix-turn helix; Region: HTH_29; pfam13551 479431012855 Homeodomain-like domain; Region: HTH_32; pfam13565 479431012856 Integrase core domain; Region: rve; pfam00665 479431012857 Integrase core domain; Region: rve_3; cl15866 479431012858 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 479431012859 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431012860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431012861 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 479431012862 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 479431012863 heme-binding site [chemical binding]; other site 479431012864 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 479431012865 FAD binding pocket [chemical binding]; other site 479431012866 FAD binding motif [chemical binding]; other site 479431012867 phosphate binding motif [ion binding]; other site 479431012868 beta-alpha-beta structure motif; other site 479431012869 NAD binding pocket [chemical binding]; other site 479431012870 DivIVA domain; Region: DivI1A_domain; TIGR03544 479431012871 DivIVA protein; Region: DivIVA; pfam05103 479431012872 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 479431012873 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 479431012874 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 479431012875 active site 479431012876 nucleophile elbow; other site 479431012877 SnoaL-like domain; Region: SnoaL_2; pfam12680 479431012878 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431012879 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431012880 Peptidase family M48; Region: Peptidase_M48; pfam01435 479431012881 biotin carboxylase-like protein; Validated; Region: PRK06524 479431012882 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431012883 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 479431012884 active site 479431012885 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 479431012886 Predicted membrane protein [Function unknown]; Region: COG4425 479431012887 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 479431012888 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 479431012889 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479431012890 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 479431012891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479431012892 inhibitor-cofactor binding pocket; inhibition site 479431012893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431012894 catalytic residue [active] 479431012895 succinic semialdehyde dehydrogenase; Region: PLN02278 479431012896 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 479431012897 tetramerization interface [polypeptide binding]; other site 479431012898 NAD(P) binding site [chemical binding]; other site 479431012899 catalytic residues [active] 479431012900 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479431012901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431012902 tyramine oxidase; Provisional; Region: tynA; PRK11504 479431012903 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 479431012904 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 479431012905 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 479431012906 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 479431012907 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 479431012908 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 479431012909 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 479431012910 putative active site [active] 479431012911 putative substrate binding site [chemical binding]; other site 479431012912 putative cosubstrate binding site; other site 479431012913 catalytic site [active] 479431012914 PAC2 family; Region: PAC2; pfam09754 479431012915 Ion channel; Region: Ion_trans_2; pfam07885 479431012916 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479431012917 TrkA-N domain; Region: TrkA_N; pfam02254 479431012918 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479431012919 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 479431012920 ANTAR domain; Region: ANTAR; pfam03861 479431012921 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 479431012922 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431012923 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431012924 DNA binding residues [nucleotide binding] 479431012925 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479431012926 catalytic core [active] 479431012927 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 479431012928 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 479431012929 active site 479431012930 dimerization interface [polypeptide binding]; other site 479431012931 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479431012932 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431012933 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 479431012934 putative deacylase active site [active] 479431012935 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 479431012936 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 479431012937 FMN binding site [chemical binding]; other site 479431012938 active site 479431012939 catalytic residues [active] 479431012940 substrate binding site [chemical binding]; other site 479431012941 Transcriptional regulator [Transcription]; Region: LytR; COG1316 479431012942 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 479431012943 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 479431012944 PhoU domain; Region: PhoU; pfam01895 479431012945 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 479431012946 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 479431012947 Walker A/P-loop; other site 479431012948 ATP binding site [chemical binding]; other site 479431012949 Q-loop/lid; other site 479431012950 ABC transporter signature motif; other site 479431012951 Walker B; other site 479431012952 D-loop; other site 479431012953 H-loop/switch region; other site 479431012954 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 479431012955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431012956 dimer interface [polypeptide binding]; other site 479431012957 conserved gate region; other site 479431012958 putative PBP binding loops; other site 479431012959 ABC-ATPase subunit interface; other site 479431012960 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 479431012961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431012962 dimer interface [polypeptide binding]; other site 479431012963 conserved gate region; other site 479431012964 putative PBP binding loops; other site 479431012965 ABC-ATPase subunit interface; other site 479431012966 PBP superfamily domain; Region: PBP_like_2; cl17296 479431012967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479431012968 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479431012969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479431012970 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431012971 DNA binding site [nucleotide binding] 479431012972 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479431012973 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431012974 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479431012975 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 479431012976 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 479431012977 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 479431012978 active site residue [active] 479431012979 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 479431012980 active site residue [active] 479431012981 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 479431012982 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 479431012983 heme-binding site [chemical binding]; other site 479431012984 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 479431012985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431012986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431012987 DNA binding residues [nucleotide binding] 479431012988 CsbD-like; Region: CsbD; pfam05532 479431012989 Asp23 family; Region: Asp23; pfam03780 479431012990 Asp23 family; Region: Asp23; pfam03780 479431012991 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 479431012992 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 479431012993 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 479431012994 putative acyl-acceptor binding pocket; other site 479431012995 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 479431012996 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 479431012997 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479431012998 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479431012999 putative acyl-acceptor binding pocket; other site 479431013000 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 479431013001 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 479431013002 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 479431013003 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 479431013004 active site 479431013005 CopC domain; Region: CopC; cl01012 479431013006 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 479431013007 Protein of unknown function (DUF461); Region: DUF461; pfam04314 479431013008 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479431013009 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479431013010 active site 479431013011 catalytic tetrad [active] 479431013012 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431013013 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431013014 metal binding site [ion binding]; metal-binding site 479431013015 active site 479431013016 I-site; other site 479431013017 phosphoglucomutase; Validated; Region: PRK07564 479431013018 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 479431013019 active site 479431013020 substrate binding site [chemical binding]; other site 479431013021 metal binding site [ion binding]; metal-binding site 479431013022 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479431013023 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479431013024 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431013025 active site 479431013026 ATP binding site [chemical binding]; other site 479431013027 substrate binding site [chemical binding]; other site 479431013028 activation loop (A-loop); other site 479431013029 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479431013030 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479431013031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431013032 Walker A/P-loop; other site 479431013033 ATP binding site [chemical binding]; other site 479431013034 Q-loop/lid; other site 479431013035 ABC transporter signature motif; other site 479431013036 Walker B; other site 479431013037 D-loop; other site 479431013038 H-loop/switch region; other site 479431013039 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431013040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431013041 active site 479431013042 phosphorylation site [posttranslational modification] 479431013043 intermolecular recognition site; other site 479431013044 dimerization interface [polypeptide binding]; other site 479431013045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431013046 DNA binding residues [nucleotide binding] 479431013047 dimerization interface [polypeptide binding]; other site 479431013048 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 479431013049 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479431013050 substrate binding site [chemical binding]; other site 479431013051 ATP binding site [chemical binding]; other site 479431013052 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 479431013053 Predicted ATPase [General function prediction only]; Region: COG3899 479431013054 AAA ATPase domain; Region: AAA_16; pfam13191 479431013055 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431013056 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431013057 DNA binding residues [nucleotide binding] 479431013058 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479431013059 active site 479431013060 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431013061 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 479431013062 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479431013063 active site 479431013064 catalytic residues [active] 479431013065 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 479431013066 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 479431013067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431013068 catalytic residue [active] 479431013069 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 479431013070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431013071 active site 479431013072 phosphorylation site [posttranslational modification] 479431013073 intermolecular recognition site; other site 479431013074 dimerization interface [polypeptide binding]; other site 479431013075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479431013076 DNA binding site [nucleotide binding] 479431013077 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 479431013078 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 479431013079 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 479431013080 Ligand Binding Site [chemical binding]; other site 479431013081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431013082 dimer interface [polypeptide binding]; other site 479431013083 phosphorylation site [posttranslational modification] 479431013084 K+-transporting ATPase, c chain; Region: KdpC; cl00944 479431013085 K+-transporting ATPase, c chain; Region: KdpC; cl00944 479431013086 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 479431013087 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479431013088 Soluble P-type ATPase [General function prediction only]; Region: COG4087 479431013089 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 479431013090 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 479431013091 pantothenate kinase; Provisional; Region: PRK05439 479431013092 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 479431013093 ATP-binding site [chemical binding]; other site 479431013094 CoA-binding site [chemical binding]; other site 479431013095 Mg2+-binding site [ion binding]; other site 479431013096 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 479431013097 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 479431013098 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 479431013099 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 479431013100 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479431013101 tetramer interface [polypeptide binding]; other site 479431013102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431013103 catalytic residue [active] 479431013104 L-asparaginase II; Region: Asparaginase_II; pfam06089 479431013105 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 479431013106 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 479431013107 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 479431013108 oligomer interface [polypeptide binding]; other site 479431013109 metal binding site [ion binding]; metal-binding site 479431013110 metal binding site [ion binding]; metal-binding site 479431013111 putative Cl binding site [ion binding]; other site 479431013112 aspartate ring; other site 479431013113 basic sphincter; other site 479431013114 hydrophobic gate; other site 479431013115 periplasmic entrance; other site 479431013116 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 479431013117 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 479431013118 dimer interface [polypeptide binding]; other site 479431013119 active site 479431013120 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479431013121 catalytic residues [active] 479431013122 substrate binding site [chemical binding]; other site 479431013123 H+ Antiporter protein; Region: 2A0121; TIGR00900 479431013124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431013125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431013126 short chain dehydrogenase; Validated; Region: PRK06182 479431013127 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 479431013128 NADP binding site [chemical binding]; other site 479431013129 active site 479431013130 steroid binding site; other site 479431013131 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479431013132 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 479431013133 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 479431013134 dimerization interface [polypeptide binding]; other site 479431013135 putative ATP binding site [chemical binding]; other site 479431013136 amidophosphoribosyltransferase; Provisional; Region: PRK07847 479431013137 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 479431013138 active site 479431013139 tetramer interface [polypeptide binding]; other site 479431013140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479431013141 active site 479431013142 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479431013143 short chain dehydrogenase; Provisional; Region: PRK06523 479431013144 classical (c) SDRs; Region: SDR_c; cd05233 479431013145 NAD(P) binding site [chemical binding]; other site 479431013146 active site 479431013147 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431013148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479431013149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479431013150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479431013151 dimerization interface [polypeptide binding]; other site 479431013152 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 479431013153 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 479431013154 dimerization interface [polypeptide binding]; other site 479431013155 ATP binding site [chemical binding]; other site 479431013156 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 479431013157 dimerization interface [polypeptide binding]; other site 479431013158 ATP binding site [chemical binding]; other site 479431013159 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 479431013160 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 479431013161 putative active site [active] 479431013162 catalytic triad [active] 479431013163 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 479431013164 Predicted flavoprotein [General function prediction only]; Region: COG0431 479431013165 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479431013166 Acyltransferase family; Region: Acyl_transf_3; pfam01757 479431013167 CAAX protease self-immunity; Region: Abi; pfam02517 479431013168 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 479431013169 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479431013170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431013171 S-adenosylmethionine binding site [chemical binding]; other site 479431013172 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 479431013173 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 479431013174 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479431013175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431013176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431013177 DNA binding residues [nucleotide binding] 479431013178 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431013179 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 479431013180 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 479431013181 ATP binding site [chemical binding]; other site 479431013182 active site 479431013183 substrate binding site [chemical binding]; other site 479431013184 HutD; Region: HutD; cl01532 479431013185 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 479431013186 Protein of unknown function (DUF419); Region: DUF419; pfam04237 479431013187 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 479431013188 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 479431013189 active site 479431013190 Zn binding site [ion binding]; other site 479431013191 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 479431013192 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479431013193 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479431013194 active site 479431013195 ATP binding site [chemical binding]; other site 479431013196 substrate binding site [chemical binding]; other site 479431013197 activation loop (A-loop); other site 479431013198 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431013199 Ligand Binding Site [chemical binding]; other site 479431013200 HAMP domain; Region: HAMP; pfam00672 479431013201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479431013202 Histidine kinase; Region: HisKA_3; pfam07730 479431013203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479431013204 ATP binding site [chemical binding]; other site 479431013205 Mg2+ binding site [ion binding]; other site 479431013206 G-X-G motif; other site 479431013207 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431013208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479431013209 active site 479431013210 phosphorylation site [posttranslational modification] 479431013211 intermolecular recognition site; other site 479431013212 dimerization interface [polypeptide binding]; other site 479431013213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431013214 DNA binding residues [nucleotide binding] 479431013215 dimerization interface [polypeptide binding]; other site 479431013216 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479431013217 Beta-lactamase; Region: Beta-lactamase; pfam00144 479431013218 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479431013219 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431013220 dimerization interface [polypeptide binding]; other site 479431013221 putative DNA binding site [nucleotide binding]; other site 479431013222 putative Zn2+ binding site [ion binding]; other site 479431013223 SAP domain; Region: SAP; pfam02037 479431013224 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 479431013225 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 479431013226 tetramer interface [polypeptide binding]; other site 479431013227 LysE type translocator; Region: LysE; cl00565 479431013228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431013229 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479431013230 NAD(P) binding site [chemical binding]; other site 479431013231 active site 479431013232 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479431013233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431013234 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479431013235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431013236 DNA binding residues [nucleotide binding] 479431013237 Anti-sigma-K factor rskA; Region: RskA; pfam10099 479431013238 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 479431013239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431013240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431013241 DNA binding residues [nucleotide binding] 479431013242 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 479431013243 Moco binding site; other site 479431013244 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 479431013245 metal coordination site [ion binding]; other site 479431013246 Domain of unknown function (DUF222); Region: DUF222; pfam02720 479431013247 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479431013248 active site 479431013249 MarR family; Region: MarR_2; pfam12802 479431013250 Cupin domain; Region: Cupin_2; pfam07883 479431013251 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 479431013252 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 479431013253 active site 479431013254 dimer interface [polypeptide binding]; other site 479431013255 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 479431013256 Ligand Binding Site [chemical binding]; other site 479431013257 Molecular Tunnel; other site 479431013258 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479431013259 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 479431013260 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479431013261 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 479431013262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 479431013263 Bacterial transcriptional activator domain; Region: BTAD; smart01043 479431013264 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479431013265 SnoaL-like domain; Region: SnoaL_3; pfam13474 479431013266 SnoaL-like domain; Region: SnoaL_2; pfam12680 479431013267 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479431013268 Cytochrome P450; Region: p450; pfam00067 479431013269 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 479431013270 Flavodoxin; Region: Flavodoxin_1; pfam00258 479431013271 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 479431013272 FAD binding pocket [chemical binding]; other site 479431013273 FAD binding motif [chemical binding]; other site 479431013274 catalytic residues [active] 479431013275 NAD binding pocket [chemical binding]; other site 479431013276 phosphate binding motif [ion binding]; other site 479431013277 beta-alpha-beta structure motif; other site 479431013278 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 479431013279 UbiA prenyltransferase family; Region: UbiA; pfam01040 479431013280 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 479431013281 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 479431013282 malonyl-CoA binding site [chemical binding]; other site 479431013283 dimer interface [polypeptide binding]; other site 479431013284 active site 479431013285 product binding site; other site 479431013286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 479431013287 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 479431013288 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 479431013289 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 479431013290 choline dehydrogenase; Validated; Region: PRK02106 479431013291 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479431013292 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 479431013293 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479431013294 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 479431013295 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479431013296 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431013297 active site 479431013298 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479431013299 hydrophobic ligand binding site; other site 479431013300 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 479431013301 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479431013302 inhibitor-cofactor binding pocket; inhibition site 479431013303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431013304 catalytic residue [active] 479431013305 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 479431013306 Male sterility protein; Region: NAD_binding_4; pfam07993 479431013307 NAD(P) binding site [chemical binding]; other site 479431013308 active site 479431013309 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 479431013310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479431013311 aspartate aminotransferase; Provisional; Region: PRK05764 479431013312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431013313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431013314 homodimer interface [polypeptide binding]; other site 479431013315 catalytic residue [active] 479431013316 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 479431013317 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 479431013318 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 479431013319 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 479431013320 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479431013321 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479431013322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431013323 Coenzyme A binding pocket [chemical binding]; other site 479431013324 putative active site [active] 479431013325 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 479431013326 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431013327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431013328 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431013329 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 479431013330 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 479431013331 GDP-binding site [chemical binding]; other site 479431013332 ACT binding site; other site 479431013333 IMP binding site; other site 479431013334 aminotransferase AlaT; Validated; Region: PRK09265 479431013335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431013336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431013337 homodimer interface [polypeptide binding]; other site 479431013338 catalytic residue [active] 479431013339 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 479431013340 Proteins of 100 residues with WXG; Region: WXG100; cl02005 479431013341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431013342 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479431013343 NAD(P) binding site [chemical binding]; other site 479431013344 active site 479431013345 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 479431013346 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 479431013347 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 479431013348 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479431013349 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479431013350 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 479431013351 EamA-like transporter family; Region: EamA; pfam00892 479431013352 EamA-like transporter family; Region: EamA; pfam00892 479431013353 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 479431013354 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 479431013355 active site 479431013356 intersubunit interface [polypeptide binding]; other site 479431013357 zinc binding site [ion binding]; other site 479431013358 Na+ binding site [ion binding]; other site 479431013359 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479431013360 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479431013361 DNA binding site [nucleotide binding] 479431013362 domain linker motif; other site 479431013363 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479431013364 ligand binding site [chemical binding]; other site 479431013365 dimerization interface [polypeptide binding]; other site 479431013366 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479431013367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431013368 dimer interface [polypeptide binding]; other site 479431013369 conserved gate region; other site 479431013370 putative PBP binding loops; other site 479431013371 ABC-ATPase subunit interface; other site 479431013372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479431013373 dimer interface [polypeptide binding]; other site 479431013374 conserved gate region; other site 479431013375 putative PBP binding loops; other site 479431013376 ABC-ATPase subunit interface; other site 479431013377 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479431013378 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 479431013379 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479431013380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431013381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431013382 DNA binding residues [nucleotide binding] 479431013383 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479431013384 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 479431013385 putative active site [active] 479431013386 FAD binding domain; Region: FAD_binding_4; pfam01565 479431013387 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 479431013388 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 479431013389 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 479431013390 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 479431013391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479431013392 active site 479431013393 CsbD-like; Region: CsbD; pfam05532 479431013394 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 479431013395 classical (c) SDRs; Region: SDR_c; cd05233 479431013396 NAD(P) binding site [chemical binding]; other site 479431013397 active site 479431013398 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479431013399 DinB superfamily; Region: DinB_2; pfam12867 479431013400 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 479431013401 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 479431013402 active site 479431013403 substrate binding site [chemical binding]; other site 479431013404 coenzyme B12 binding site [chemical binding]; other site 479431013405 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 479431013406 B12 binding site [chemical binding]; other site 479431013407 cobalt ligand [ion binding]; other site 479431013408 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 479431013409 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 479431013410 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 479431013411 Clp amino terminal domain; Region: Clp_N; pfam02861 479431013412 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 479431013413 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479431013414 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 479431013415 motif 1; other site 479431013416 active site 479431013417 motif 2; other site 479431013418 motif 3; other site 479431013419 fructose 1,6-bisphosphatase II; Reviewed; Region: glpX; PRK09479 479431013420 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 479431013421 active site 479431013422 Amino acid permease; Region: AA_permease_2; pfam13520 479431013423 MMPL family; Region: MMPL; pfam03176 479431013424 MMPL family; Region: MMPL; pfam03176 479431013425 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479431013426 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 479431013427 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 479431013428 Walker A/P-loop; other site 479431013429 ATP binding site [chemical binding]; other site 479431013430 Q-loop/lid; other site 479431013431 ABC transporter signature motif; other site 479431013432 Walker B; other site 479431013433 D-loop; other site 479431013434 H-loop/switch region; other site 479431013435 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 479431013436 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 479431013437 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 479431013438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431013439 dimerization interface [polypeptide binding]; other site 479431013440 putative DNA binding site [nucleotide binding]; other site 479431013441 putative Zn2+ binding site [ion binding]; other site 479431013442 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 479431013443 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 479431013444 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 479431013445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431013446 S-adenosylmethionine binding site [chemical binding]; other site 479431013447 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431013448 Ligand Binding Site [chemical binding]; other site 479431013449 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 479431013450 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 479431013451 thiamine phosphate binding site [chemical binding]; other site 479431013452 active site 479431013453 pyrophosphate binding site [ion binding]; other site 479431013454 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 479431013455 substrate binding site [chemical binding]; other site 479431013456 multimerization interface [polypeptide binding]; other site 479431013457 ATP binding site [chemical binding]; other site 479431013458 MMPL family; Region: MMPL; pfam03176 479431013459 AAA ATPase domain; Region: AAA_16; pfam13191 479431013460 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431013461 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431013462 DNA binding residues [nucleotide binding] 479431013463 dimerization interface [polypeptide binding]; other site 479431013464 RDD family; Region: RDD; pfam06271 479431013465 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 479431013466 Clp amino terminal domain; Region: Clp_N; pfam02861 479431013467 Clp amino terminal domain; Region: Clp_N; pfam02861 479431013468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431013469 Walker A motif; other site 479431013470 ATP binding site [chemical binding]; other site 479431013471 Walker B motif; other site 479431013472 arginine finger; other site 479431013473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431013474 Walker A motif; other site 479431013475 ATP binding site [chemical binding]; other site 479431013476 Walker B motif; other site 479431013477 arginine finger; other site 479431013478 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 479431013479 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 479431013480 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 479431013481 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 479431013482 active site 479431013483 Ca binding site [ion binding]; other site 479431013484 catalytic site [active] 479431013485 Aamy_C domain; Region: Aamy_C; smart00632 479431013486 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479431013487 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479431013488 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479431013489 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 479431013490 putative active site; other site 479431013491 putative metal binding residues [ion binding]; other site 479431013492 signature motif; other site 479431013493 putative triphosphate binding site [ion binding]; other site 479431013494 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 479431013495 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 479431013496 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 479431013497 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479431013498 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 479431013499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431013500 catalytic residue [active] 479431013501 Predicted membrane protein [Function unknown]; Region: COG3463 479431013502 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 479431013503 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479431013504 Clp protease; Region: CLP_protease; pfam00574 479431013505 oligomer interface [polypeptide binding]; other site 479431013506 active site residues [active] 479431013507 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 479431013508 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479431013509 oligomer interface [polypeptide binding]; other site 479431013510 active site residues [active] 479431013511 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431013512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431013513 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431013514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479431013515 non-specific DNA binding site [nucleotide binding]; other site 479431013516 salt bridge; other site 479431013517 sequence-specific DNA binding site [nucleotide binding]; other site 479431013518 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 479431013519 AAA ATPase domain; Region: AAA_16; pfam13191 479431013520 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431013521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431013522 DNA binding residues [nucleotide binding] 479431013523 dimerization interface [polypeptide binding]; other site 479431013524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479431013525 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 479431013526 putative active site [active] 479431013527 heme pocket [chemical binding]; other site 479431013528 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431013529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431013530 metal binding site [ion binding]; metal-binding site 479431013531 active site 479431013532 I-site; other site 479431013533 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 479431013534 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 479431013535 DNA binding residues [nucleotide binding] 479431013536 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479431013537 putative dimer interface [polypeptide binding]; other site 479431013538 chaperone protein DnaJ; Provisional; Region: PRK14279 479431013539 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 479431013540 HSP70 interaction site [polypeptide binding]; other site 479431013541 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 479431013542 Zn binding sites [ion binding]; other site 479431013543 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 479431013544 dimer interface [polypeptide binding]; other site 479431013545 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 479431013546 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 479431013547 dimer interface [polypeptide binding]; other site 479431013548 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 479431013549 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 479431013550 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 479431013551 nucleotide binding site [chemical binding]; other site 479431013552 NEF interaction site [polypeptide binding]; other site 479431013553 SBD interface [polypeptide binding]; other site 479431013554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431013555 dimerization interface [polypeptide binding]; other site 479431013556 putative DNA binding site [nucleotide binding]; other site 479431013557 putative Zn2+ binding site [ion binding]; other site 479431013558 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 479431013559 putative hydrophobic ligand binding site [chemical binding]; other site 479431013560 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479431013561 active site 479431013562 metal binding site [ion binding]; metal-binding site 479431013563 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431013564 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 479431013565 dimer interface [polypeptide binding]; other site 479431013566 FAD binding domain; Region: FAD_binding_4; pfam01565 479431013567 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 479431013568 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479431013569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479431013570 DNA-binding site [nucleotide binding]; DNA binding site 479431013571 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 479431013572 L-lactate permease; Region: Lactate_perm; cl00701 479431013573 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 479431013574 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 479431013575 Cysteine-rich domain; Region: CCG; pfam02754 479431013576 Cysteine-rich domain; Region: CCG; pfam02754 479431013577 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 479431013578 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 479431013579 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 479431013580 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 479431013581 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 479431013582 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479431013583 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 479431013584 intersubunit interface [polypeptide binding]; other site 479431013585 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 479431013586 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479431013587 dimer interface [polypeptide binding]; other site 479431013588 putative PBP binding regions; other site 479431013589 ABC-ATPase subunit interface; other site 479431013590 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431013591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431013592 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431013593 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479431013594 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479431013595 Walker A/P-loop; other site 479431013596 ATP binding site [chemical binding]; other site 479431013597 Q-loop/lid; other site 479431013598 ABC transporter signature motif; other site 479431013599 Walker B; other site 479431013600 D-loop; other site 479431013601 H-loop/switch region; other site 479431013602 Predicted membrane protein [Function unknown]; Region: COG4425 479431013603 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 479431013604 CAAX protease self-immunity; Region: Abi; pfam02517 479431013605 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479431013606 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479431013607 DNA binding residues [nucleotide binding] 479431013608 dimerization interface [polypeptide binding]; other site 479431013609 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 479431013610 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431013611 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431013612 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479431013613 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 479431013614 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 479431013615 hypothetical protein; Provisional; Region: PRK07877 479431013616 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 479431013617 ATP binding site [chemical binding]; other site 479431013618 substrate interface [chemical binding]; other site 479431013619 GAF domain; Region: GAF; cl17456 479431013620 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431013621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431013622 metal binding site [ion binding]; metal-binding site 479431013623 active site 479431013624 I-site; other site 479431013625 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 479431013626 Repair protein; Region: Repair_PSII; pfam04536 479431013627 Chain length determinant protein; Region: Wzz; cl15801 479431013628 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 479431013629 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 479431013630 Nucleotide binding site [chemical binding]; other site 479431013631 P loop; other site 479431013632 DTAP/Switch II; other site 479431013633 Switch I; other site 479431013634 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 479431013635 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 479431013636 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 479431013637 NAD(P) binding site [chemical binding]; other site 479431013638 homodimer interface [polypeptide binding]; other site 479431013639 substrate binding site [chemical binding]; other site 479431013640 active site 479431013641 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 479431013642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479431013643 NAD(P) binding site [chemical binding]; other site 479431013644 active site 479431013645 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 479431013646 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 479431013647 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 479431013648 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 479431013649 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479431013650 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 479431013651 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 479431013652 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 479431013653 putative trimer interface [polypeptide binding]; other site 479431013654 putative CoA binding site [chemical binding]; other site 479431013655 Bacterial sugar transferase; Region: Bac_transf; pfam02397 479431013656 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 479431013657 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 479431013658 inhibitor-cofactor binding pocket; inhibition site 479431013659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431013660 catalytic residue [active] 479431013661 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 479431013662 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 479431013663 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 479431013664 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 479431013665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479431013666 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479431013667 Walker A/P-loop; other site 479431013668 ATP binding site [chemical binding]; other site 479431013669 Q-loop/lid; other site 479431013670 ABC transporter signature motif; other site 479431013671 Walker B; other site 479431013672 D-loop; other site 479431013673 H-loop/switch region; other site 479431013674 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 479431013675 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479431013676 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479431013677 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479431013678 Predicted ATPase [General function prediction only]; Region: COG3903 479431013679 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479431013680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431013681 active site 479431013682 Protein of unknown function (DUF975); Region: DUF975; cl10504 479431013683 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 479431013684 4Fe-4S binding domain; Region: Fer4; pfam00037 479431013685 Cysteine-rich domain; Region: CCG; pfam02754 479431013686 Cysteine-rich domain; Region: CCG; pfam02754 479431013687 Protein of unknown function (DUF998); Region: DUF998; pfam06197 479431013688 Homeodomain-like domain; Region: HTH_23; cl17451 479431013689 Winged helix-turn helix; Region: HTH_29; pfam13551 479431013690 Integrase core domain; Region: rve; pfam00665 479431013691 Integrase core domain; Region: rve_3; pfam13683 479431013692 YCII-related domain; Region: YCII; cl00999 479431013693 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479431013694 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431013695 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479431013696 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 479431013697 trimer interface [polypeptide binding]; other site 479431013698 active site 479431013699 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 479431013700 active site 479431013701 catalytic site [active] 479431013702 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479431013703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431013704 S-adenosylmethionine binding site [chemical binding]; other site 479431013705 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 479431013706 Sulfatase; Region: Sulfatase; pfam00884 479431013707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431013708 Tubby C 2; Region: Tub_2; cl02043 479431013709 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 479431013710 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 479431013711 active site 479431013712 DNA binding site [nucleotide binding] 479431013713 catalytic site [active] 479431013714 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 479431013715 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 479431013716 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479431013717 molybdopterin cofactor binding site; other site 479431013718 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479431013719 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479431013720 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 479431013721 molybdopterin cofactor binding site; other site 479431013722 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 479431013723 4Fe-4S binding domain; Region: Fer4; cl02805 479431013724 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 479431013725 selenium donor protein; Region: selD; TIGR00476 479431013726 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 479431013727 dimerization interface [polypeptide binding]; other site 479431013728 putative ATP binding site [chemical binding]; other site 479431013729 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431013730 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 479431013731 dimer interface [polypeptide binding]; other site 479431013732 selenocysteine synthase; Provisional; Region: PRK04311 479431013733 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479431013734 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 479431013735 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 479431013736 G1 box; other site 479431013737 GTP/Mg2+ binding site [chemical binding]; other site 479431013738 G2 box; other site 479431013739 Switch I region; other site 479431013740 G3 box; other site 479431013741 Switch II region; other site 479431013742 G4 box; other site 479431013743 G5 box; other site 479431013744 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 479431013745 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 479431013746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479431013747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479431013748 Coenzyme A binding pocket [chemical binding]; other site 479431013749 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 479431013750 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 479431013751 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 479431013752 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 479431013753 Transposase; Region: DEDD_Tnp_IS110; pfam01548 479431013754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 479431013755 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 479431013756 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 479431013757 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 479431013758 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 479431013759 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 479431013760 XdhC Rossmann domain; Region: XdhC_C; pfam13478 479431013761 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 479431013762 MoxR-like ATPases [General function prediction only]; Region: COG0714 479431013763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479431013764 Walker A motif; other site 479431013765 ATP binding site [chemical binding]; other site 479431013766 Walker B motif; other site 479431013767 arginine finger; other site 479431013768 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 479431013769 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479431013770 metal ion-dependent adhesion site (MIDAS); other site 479431013771 Protein of unknown function (DUF998); Region: DUF998; pfam06197 479431013772 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 479431013773 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479431013774 CGNR zinc finger; Region: zf-CGNR; pfam11706 479431013775 Predicted acyl esterases [General function prediction only]; Region: COG2936 479431013776 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 479431013777 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 479431013778 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 479431013779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479431013780 active site 479431013781 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 479431013782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479431013783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479431013784 dimer interface [polypeptide binding]; other site 479431013785 phosphorylation site [posttranslational modification] 479431013786 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 479431013787 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 479431013788 active site 479431013789 substrate binding site [chemical binding]; other site 479431013790 FMN binding site [chemical binding]; other site 479431013791 putative catalytic residues [active] 479431013792 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 479431013793 Fe-S cluster binding site [ion binding]; other site 479431013794 DNA binding site [nucleotide binding] 479431013795 active site 479431013796 glycerol kinase; Provisional; Region: glpK; PRK00047 479431013797 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 479431013798 N- and C-terminal domain interface [polypeptide binding]; other site 479431013799 active site 479431013800 MgATP binding site [chemical binding]; other site 479431013801 catalytic site [active] 479431013802 metal binding site [ion binding]; metal-binding site 479431013803 putative homotetramer interface [polypeptide binding]; other site 479431013804 glycerol binding site [chemical binding]; other site 479431013805 homodimer interface [polypeptide binding]; other site 479431013806 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 479431013807 amphipathic channel; other site 479431013808 Asn-Pro-Ala signature motifs; other site 479431013809 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 479431013810 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 479431013811 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 479431013812 putative active site [active] 479431013813 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479431013814 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479431013815 Bacterial transcriptional regulator; Region: IclR; pfam01614 479431013816 glycerol kinase; Provisional; Region: glpK; PRK00047 479431013817 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479431013818 nucleotide binding site [chemical binding]; other site 479431013819 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431013820 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431013821 metal binding site [ion binding]; metal-binding site 479431013822 active site 479431013823 I-site; other site 479431013824 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 479431013825 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 479431013826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431013827 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479431013828 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 479431013829 oligomerisation interface [polypeptide binding]; other site 479431013830 mobile loop; other site 479431013831 roof hairpin; other site 479431013832 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 479431013833 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479431013834 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479431013835 catalytic residue [active] 479431013836 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 479431013837 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479431013838 E3 interaction surface; other site 479431013839 lipoyl attachment site [posttranslational modification]; other site 479431013840 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 479431013841 e3 binding domain; Region: E3_binding; pfam02817 479431013842 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479431013843 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479431013844 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 479431013845 alpha subunit interface [polypeptide binding]; other site 479431013846 TPP binding site [chemical binding]; other site 479431013847 heterodimer interface [polypeptide binding]; other site 479431013848 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479431013849 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 479431013850 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479431013851 tetramer interface [polypeptide binding]; other site 479431013852 TPP-binding site [chemical binding]; other site 479431013853 heterodimer interface [polypeptide binding]; other site 479431013854 phosphorylation loop region [posttranslational modification] 479431013855 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 479431013856 putative hydrophobic ligand binding site [chemical binding]; other site 479431013857 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479431013858 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479431013859 metal binding site [ion binding]; metal-binding site 479431013860 active site 479431013861 I-site; other site 479431013862 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 479431013863 active site 479431013864 substrate-binding site [chemical binding]; other site 479431013865 metal-binding site [ion binding] 479431013866 GTP binding site [chemical binding]; other site 479431013867 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 479431013868 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 479431013869 putative active site [active] 479431013870 putative dimer interface [polypeptide binding]; other site 479431013871 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 479431013872 inhibitor binding site; inhibition site 479431013873 catalytic motif [active] 479431013874 Catalytic residue [active] 479431013875 Active site flap [active] 479431013876 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 479431013877 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 479431013878 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479431013879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479431013880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479431013881 DNA binding residues [nucleotide binding] 479431013882 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 479431013883 CHAT domain; Region: CHAT; pfam12770 479431013884 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 479431013885 active site 479431013886 catalytic residues [active] 479431013887 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479431013888 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 479431013889 Walker A/P-loop; other site 479431013890 ATP binding site [chemical binding]; other site 479431013891 Q-loop/lid; other site 479431013892 ABC transporter signature motif; other site 479431013893 Walker B; other site 479431013894 D-loop; other site 479431013895 H-loop/switch region; other site 479431013896 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479431013897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431013898 S-adenosylmethionine binding site [chemical binding]; other site 479431013899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431013900 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431013901 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 479431013902 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 479431013903 Divergent AAA domain; Region: AAA_4; pfam04326 479431013904 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 479431013905 multiple promoter invertase; Provisional; Region: mpi; PRK13413 479431013906 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 479431013907 catalytic residues [active] 479431013908 catalytic nucleophile [active] 479431013909 Presynaptic Site I dimer interface [polypeptide binding]; other site 479431013910 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 479431013911 Synaptic Flat tetramer interface [polypeptide binding]; other site 479431013912 Synaptic Site I dimer interface [polypeptide binding]; other site 479431013913 DNA binding site [nucleotide binding] 479431013914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 479431013915 Integrase core domain; Region: rve; pfam00665 479431013916 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 479431013917 active site 479431013918 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 479431013919 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 479431013920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431013921 catalytic residue [active] 479431013922 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 479431013923 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 479431013924 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 479431013925 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 479431013926 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 479431013927 threonine dehydratase; Validated; Region: PRK08639 479431013928 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479431013929 tetramer interface [polypeptide binding]; other site 479431013930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431013931 catalytic residue [active] 479431013932 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 479431013933 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479431013934 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 479431013935 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 479431013936 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479431013937 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479431013938 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479431013939 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479431013940 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479431013941 TM-ABC transporter signature motif; other site 479431013942 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479431013943 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479431013944 Walker A/P-loop; other site 479431013945 ATP binding site [chemical binding]; other site 479431013946 Q-loop/lid; other site 479431013947 ABC transporter signature motif; other site 479431013948 Walker B; other site 479431013949 D-loop; other site 479431013950 H-loop/switch region; other site 479431013951 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 479431013952 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 479431013953 putative ligand binding site [chemical binding]; other site 479431013954 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 479431013955 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 479431013956 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 479431013957 shikimate binding site; other site 479431013958 NAD(P) binding site [chemical binding]; other site 479431013959 Class I aldolases; Region: Aldolase_Class_I; cl17187 479431013960 catalytic residue [active] 479431013961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431013962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479431013963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479431013964 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479431013965 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 479431013966 pyridoxamine kinase; Validated; Region: PRK05756 479431013967 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 479431013968 dimer interface [polypeptide binding]; other site 479431013969 pyridoxal binding site [chemical binding]; other site 479431013970 ATP binding site [chemical binding]; other site 479431013971 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 479431013972 putative hydrophobic ligand binding site [chemical binding]; other site 479431013973 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 479431013974 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 479431013975 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 479431013976 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 479431013977 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479431013978 catalytic loop [active] 479431013979 iron binding site [ion binding]; other site 479431013980 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 479431013981 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 479431013982 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 479431013983 membrane protein FdrA; Validated; Region: PRK06091 479431013984 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 479431013985 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 479431013986 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 479431013987 Helix-turn-helix domain; Region: HTH_38; pfam13936 479431013988 Integrase core domain; Region: rve; pfam00665 479431013989 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479431013990 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 479431013991 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 479431013992 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 479431013993 Walker A motif; other site 479431013994 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 479431013995 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 479431013996 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 479431013997 ATP binding site [chemical binding]; other site 479431013998 Walker B motif; other site 479431013999 DNA binding loops [nucleotide binding] 479431014000 amino acid transporter; Region: 2A0306; TIGR00909 479431014001 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 479431014002 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431014003 Ligand Binding Site [chemical binding]; other site 479431014004 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479431014005 Ligand Binding Site [chemical binding]; other site 479431014006 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 479431014007 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 479431014008 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 479431014009 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 479431014010 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 479431014011 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 479431014012 dimer interface [polypeptide binding]; other site 479431014013 ssDNA binding site [nucleotide binding]; other site 479431014014 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479431014015 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 479431014016 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 479431014017 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479431014018 dimer interface [polypeptide binding]; other site 479431014019 active site 479431014020 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 479431014021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431014022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431014023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479431014024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431014025 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 479431014026 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 479431014027 TPP-binding site [chemical binding]; other site 479431014028 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 479431014029 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 479431014030 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 479431014031 dimer interface [polypeptide binding]; other site 479431014032 PYR/PP interface [polypeptide binding]; other site 479431014033 TPP binding site [chemical binding]; other site 479431014034 substrate binding site [chemical binding]; other site 479431014035 Predicted integral membrane protein [Function unknown]; Region: COG5650 479431014036 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479431014037 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479431014038 dimerization interface [polypeptide binding]; other site 479431014039 putative DNA binding site [nucleotide binding]; other site 479431014040 putative Zn2+ binding site [ion binding]; other site 479431014041 Predicted transcriptional regulators [Transcription]; Region: COG1695 479431014042 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479431014043 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 479431014044 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 479431014045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 479431014046 Transposase; Region: DDE_Tnp_ISL3; pfam01610 479431014047 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 479431014048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479431014049 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 479431014050 nucleophilic elbow; other site 479431014051 catalytic triad; other site 479431014052 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 479431014053 TIGR02588 family protein; Region: TIGR02588 479431014054 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479431014055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479431014056 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 479431014057 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479431014058 putative NAD(P) binding site [chemical binding]; other site 479431014059 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 479431014060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431014061 active site 479431014062 HIGH motif; other site 479431014063 nucleotide binding site [chemical binding]; other site 479431014064 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 479431014065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431014066 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479431014067 active site 479431014068 KMSKS motif; other site 479431014069 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 479431014070 tRNA binding surface [nucleotide binding]; other site 479431014071 DinB superfamily; Region: DinB_2; pfam12867 479431014072 hypothetical protein; Validated; Region: PRK00228 479431014073 H+ Antiporter protein; Region: 2A0121; TIGR00900 479431014074 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 479431014075 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 479431014076 active site 479431014077 NTP binding site [chemical binding]; other site 479431014078 metal binding triad [ion binding]; metal-binding site 479431014079 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 479431014080 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479431014081 Zn2+ binding site [ion binding]; other site 479431014082 Mg2+ binding site [ion binding]; other site 479431014083 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 479431014084 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 479431014085 active site 479431014086 Ap6A binding site [chemical binding]; other site 479431014087 nudix motif; other site 479431014088 metal binding site [ion binding]; metal-binding site 479431014089 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 479431014090 MviN-like protein; Region: MVIN; pfam03023 479431014091 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 479431014092 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479431014093 ATP binding site [chemical binding]; other site 479431014094 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 479431014095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479431014096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479431014097 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479431014098 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 479431014099 catalytic residues [active] 479431014100 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 479431014101 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479431014102 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479431014103 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 479431014104 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 479431014105 active site 479431014106 metal binding site [ion binding]; metal-binding site 479431014107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479431014108 Coenzyme A binding pocket [chemical binding]; other site 479431014109 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 479431014110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479431014111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431014112 homodimer interface [polypeptide binding]; other site 479431014113 catalytic residue [active] 479431014114 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 479431014115 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 479431014116 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479431014117 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 479431014118 ParB-like nuclease domain; Region: ParBc; pfam02195 479431014119 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 479431014120 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479431014121 Magnesium ion binding site [ion binding]; other site 479431014122 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479431014123 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 479431014124 inhibitor-cofactor binding pocket; inhibition site 479431014125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479431014126 catalytic residue [active] 479431014127 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 479431014128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479431014129 S-adenosylmethionine binding site [chemical binding]; other site 479431014130 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 479431014131 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 479431014132 G-X-X-G motif; other site 479431014133 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 479431014134 RxxxH motif; other site 479431014135 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 479431014136 Haemolytic domain; Region: Haemolytic; pfam01809 479431014137 Ribonuclease P; Region: Ribonuclease_P; cl00457 479431014138 Ribosomal protein L34; Region: Ribosomal_L34; cl00370