-- dump date   	20140619_162424
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
457570000001	hypothetical protein; Region: PHA01623
457570000002	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
457570000003	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
457570000004	P-loop; other site
457570000005	Magnesium ion binding site [ion binding]; other site
457570000006	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
457570000007	Magnesium ion binding site [ion binding]; other site
457570000008	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
457570000009	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570000010	salt bridge; other site
457570000011	non-specific DNA binding site [nucleotide binding]; other site
457570000012	sequence-specific DNA binding site [nucleotide binding]; other site
457570000013	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
457570000014	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
457570000015	Helix-turn-helix domain; Region: HTH_17; pfam12728
457570000016	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
457570000017	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
457570000018	active site
457570000019	catalytic residues [active]
457570000020	DNA binding site [nucleotide binding]
457570000021	Int/Topo IB signature motif; other site
457570000022	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
457570000023	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
457570000024	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
457570000025	catalytic residues [active]
457570000026	catalytic nucleophile [active]
457570000027	Presynaptic Site I dimer interface [polypeptide binding]; other site
457570000028	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
457570000029	Synaptic Flat tetramer interface [polypeptide binding]; other site
457570000030	Synaptic Site I dimer interface [polypeptide binding]; other site
457570000031	DNA binding site [nucleotide binding]
457570000032	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
457570000033	DnaA N-terminal domain; Region: DnaA_N; pfam11638
457570000034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570000035	Walker A motif; other site
457570000036	ATP binding site [chemical binding]; other site
457570000037	Walker B motif; other site
457570000038	arginine finger; other site
457570000039	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
457570000040	DnaA box-binding interface [nucleotide binding]; other site
457570000041	DNA polymerase III subunit beta; Validated; Region: PRK05643
457570000042	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
457570000043	putative DNA binding surface [nucleotide binding]; other site
457570000044	dimer interface [polypeptide binding]; other site
457570000045	beta-clamp/clamp loader binding surface; other site
457570000046	beta-clamp/translesion DNA polymerase binding surface; other site
457570000047	S4 domain; Region: S4_2; pfam13275
457570000048	recombination protein F; Reviewed; Region: recF; PRK00064
457570000049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570000050	Walker A/P-loop; other site
457570000051	ATP binding site [chemical binding]; other site
457570000052	Q-loop/lid; other site
457570000053	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570000054	ABC transporter signature motif; other site
457570000055	Walker B; other site
457570000056	D-loop; other site
457570000057	H-loop/switch region; other site
457570000058	Protein of unknown function (DUF721); Region: DUF721; pfam05258
457570000059	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
457570000060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570000061	ATP binding site [chemical binding]; other site
457570000062	Mg2+ binding site [ion binding]; other site
457570000063	G-X-G motif; other site
457570000064	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
457570000065	anchoring element; other site
457570000066	dimer interface [polypeptide binding]; other site
457570000067	ATP binding site [chemical binding]; other site
457570000068	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
457570000069	active site
457570000070	putative metal-binding site [ion binding]; other site
457570000071	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
457570000072	DNA gyrase subunit A; Validated; Region: PRK05560
457570000073	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
457570000074	CAP-like domain; other site
457570000075	active site
457570000076	primary dimer interface [polypeptide binding]; other site
457570000077	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
457570000078	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
457570000079	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
457570000080	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
457570000081	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
457570000082	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
457570000083	stage V sporulation protein B; Region: spore_V_B; TIGR02900
457570000084	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
457570000085	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
457570000086	G1 box; other site
457570000087	elongation factor G; Reviewed; Region: PRK12740
457570000088	putative GEF interaction site [polypeptide binding]; other site
457570000089	GTP/Mg2+ binding site [chemical binding]; other site
457570000090	Switch I region; other site
457570000091	G2 box; other site
457570000092	G3 box; other site
457570000093	Switch II region; other site
457570000094	G4 box; other site
457570000095	G5 box; other site
457570000096	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
457570000097	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
457570000098	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
457570000099	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
457570000100	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
457570000101	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
457570000102	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
457570000103	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
457570000104	active site
457570000105	multimer interface [polypeptide binding]; other site
457570000106	T-box leader as predicted by Rfam (RF00230), score 106.73; T-box leader sequence
457570000107	seryl-tRNA synthetase; Provisional; Region: PRK05431
457570000108	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
457570000109	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
457570000110	dimer interface [polypeptide binding]; other site
457570000111	active site
457570000112	motif 1; other site
457570000113	motif 2; other site
457570000114	motif 3; other site
457570000115	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
457570000116	nucleoside/Zn binding site; other site
457570000117	dimer interface [polypeptide binding]; other site
457570000118	catalytic motif [active]
457570000119	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
457570000120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570000121	Walker A motif; other site
457570000122	ATP binding site [chemical binding]; other site
457570000123	Walker B motif; other site
457570000124	arginine finger; other site
457570000125	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
457570000126	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
457570000127	hypothetical protein; Validated; Region: PRK00153
457570000128	recombination protein RecR; Reviewed; Region: recR; PRK00076
457570000129	RecR protein; Region: RecR; pfam02132
457570000130	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
457570000131	putative active site [active]
457570000132	putative metal-binding site [ion binding]; other site
457570000133	tetramer interface [polypeptide binding]; other site
457570000134	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
457570000135	SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466
457570000136	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
457570000137	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
457570000138	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
457570000139	dimer interface [polypeptide binding]; other site
457570000140	PYR/PP interface [polypeptide binding]; other site
457570000141	TPP binding site [chemical binding]; other site
457570000142	substrate binding site [chemical binding]; other site
457570000143	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
457570000144	Domain of unknown function; Region: EKR; smart00890
457570000145	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570000146	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
457570000147	TPP-binding site [chemical binding]; other site
457570000148	dimer interface [polypeptide binding]; other site
457570000149	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
457570000150	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
457570000151	dimer interface [polypeptide binding]; other site
457570000152	PYR/PP interface [polypeptide binding]; other site
457570000153	TPP binding site [chemical binding]; other site
457570000154	substrate binding site [chemical binding]; other site
457570000155	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
457570000156	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
457570000157	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
457570000158	TPP-binding site [chemical binding]; other site
457570000159	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
457570000160	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
457570000161	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
457570000162	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
457570000163	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
457570000164	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570000165	non-specific DNA binding site [nucleotide binding]; other site
457570000166	salt bridge; other site
457570000167	sequence-specific DNA binding site [nucleotide binding]; other site
457570000168	Tetratricopeptide repeat; Region: TPR_12; pfam13424
457570000169	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
457570000170	binding surface
457570000171	TPR motif; other site
457570000172	Tetratricopeptide repeat; Region: TPR_12; pfam13424
457570000173	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
457570000174	Cell division protein FtsA; Region: FtsA; smart00842
457570000175	Cell division protein FtsA; Region: FtsA; pfam14450
457570000176	Helix-turn-helix domain; Region: HTH_28; pfam13518
457570000177	Winged helix-turn helix; Region: HTH_29; pfam13551
457570000178	Integrase core domain; Region: rve; pfam00665
457570000179	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
457570000180	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
457570000181	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
457570000182	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
457570000183	active site
457570000184	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
457570000185	Na2 binding site [ion binding]; other site
457570000186	putative substrate binding site 1 [chemical binding]; other site
457570000187	Na binding site 1 [ion binding]; other site
457570000188	putative substrate binding site 2 [chemical binding]; other site
457570000189	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
457570000190	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
457570000191	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
457570000192	catalytic residue [active]
457570000193	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
457570000194	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
457570000195	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570000196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570000197	Walker A motif; other site
457570000198	Walker A/P-loop; other site
457570000199	ATP binding site [chemical binding]; other site
457570000200	ATP binding site [chemical binding]; other site
457570000201	Walker B motif; other site
457570000202	thymidylate kinase; Validated; Region: tmk; PRK00698
457570000203	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
457570000204	TMP-binding site; other site
457570000205	ATP-binding site [chemical binding]; other site
457570000206	Protein of unknown function (DUF970); Region: DUF970; pfam06153
457570000207	Protein of unknown function (DUF327); Region: DUF327; pfam03885
457570000208	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
457570000209	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570000210	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570000211	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570000212	Integrase core domain; Region: rve; pfam00665
457570000213	Integrase core domain; Region: rve_3; cl15866
457570000214	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570000215	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
457570000216	Walker A motif; other site
457570000217	ATP binding site [chemical binding]; other site
457570000218	DNA polymerase III subunit delta'; Validated; Region: PRK07132
457570000219	Walker B motif; other site
457570000220	arginine finger; other site
457570000221	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
457570000222	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
457570000223	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
457570000224	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
457570000225	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
457570000226	Predicted methyltransferases [General function prediction only]; Region: COG0313
457570000227	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
457570000228	putative SAM binding site [chemical binding]; other site
457570000229	putative homodimer interface [polypeptide binding]; other site
457570000230	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
457570000231	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
457570000232	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
457570000233	active site
457570000234	HIGH motif; other site
457570000235	KMSKS motif; other site
457570000236	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
457570000237	tRNA binding surface [nucleotide binding]; other site
457570000238	anticodon binding site; other site
457570000239	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
457570000240	dimer interface [polypeptide binding]; other site
457570000241	putative tRNA-binding site [nucleotide binding]; other site
457570000242	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
457570000243	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
457570000244	active site
457570000245	G5 domain; Region: G5; pfam07501
457570000246	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
457570000247	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
457570000248	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
457570000249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570000250	S-adenosylmethionine binding site [chemical binding]; other site
457570000251	Protein of unknown function (DUF458); Region: DUF458; pfam04308
457570000252	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
457570000253	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
457570000254	Predicted membrane protein [Function unknown]; Region: COG2119
457570000255	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
457570000256	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
457570000257	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
457570000258	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
457570000259	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
457570000260	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
457570000261	active site
457570000262	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
457570000263	proposed catalytic triad [active]
457570000264	active site nucleophile [active]
457570000265	cyanophycin synthetase; Provisional; Region: PRK14016
457570000266	ATP-grasp domain; Region: ATP-grasp_4; cl17255
457570000267	ATP-grasp domain; Region: ATP-grasp_4; cl17255
457570000268	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
457570000269	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
457570000270	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
457570000271	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
457570000272	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
457570000273	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
457570000274	pur operon repressor; Provisional; Region: PRK09213
457570000275	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
457570000276	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
457570000277	active site
457570000278	SpoVG; Region: SpoVG; pfam04026
457570000279	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
457570000280	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
457570000281	Substrate binding site; other site
457570000282	Mg++ binding site; other site
457570000283	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
457570000284	active site
457570000285	substrate binding site [chemical binding]; other site
457570000286	CoA binding site [chemical binding]; other site
457570000287	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
457570000288	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
457570000289	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
457570000290	active site
457570000291	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
457570000292	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
457570000293	5S rRNA interface [nucleotide binding]; other site
457570000294	CTC domain interface [polypeptide binding]; other site
457570000295	L16 interface [polypeptide binding]; other site
457570000296	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
457570000297	putative active site [active]
457570000298	catalytic residue [active]
457570000299	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
457570000300	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
457570000301	Predicted membrane protein [Function unknown]; Region: COG1971
457570000302	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
457570000303	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
457570000304	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
457570000305	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
457570000306	ATP binding site [chemical binding]; other site
457570000307	putative Mg++ binding site [ion binding]; other site
457570000308	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
457570000309	nucleotide binding region [chemical binding]; other site
457570000310	ATP-binding site [chemical binding]; other site
457570000311	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
457570000312	stage V sporulation protein T; Region: spore_V_T; TIGR02851
457570000313	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
457570000314	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
457570000315	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
457570000316	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
457570000317	homodimer interface [polypeptide binding]; other site
457570000318	metal binding site [ion binding]; metal-binding site
457570000319	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
457570000320	homodimer interface [polypeptide binding]; other site
457570000321	active site
457570000322	putative chemical substrate binding site [chemical binding]; other site
457570000323	metal binding site [ion binding]; metal-binding site
457570000324	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
457570000325	IHF dimer interface [polypeptide binding]; other site
457570000326	IHF - DNA interface [nucleotide binding]; other site
457570000327	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
457570000328	Stage II sporulation protein; Region: SpoIID; pfam08486
457570000329	YabP family; Region: YabP; cl06766
457570000330	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
457570000331	hypothetical protein; Provisional; Region: PRK08582
457570000332	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
457570000333	RNA binding site [nucleotide binding]; other site
457570000334	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
457570000335	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570000336	putative active site [active]
457570000337	heme pocket [chemical binding]; other site
457570000338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
457570000339	dimer interface [polypeptide binding]; other site
457570000340	phosphorylation site [posttranslational modification]
457570000341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570000342	ATP binding site [chemical binding]; other site
457570000343	Mg2+ binding site [ion binding]; other site
457570000344	G-X-G motif; other site
457570000345	exopolyphosphatase; Region: exo_poly_only; TIGR03706
457570000346	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
457570000347	stage II sporulation protein E; Region: spore_II_E; TIGR02865
457570000348	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
457570000349	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
457570000350	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
457570000351	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
457570000352	Ligand Binding Site [chemical binding]; other site
457570000353	TilS substrate C-terminal domain; Region: TilS_C; smart00977
457570000354	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
457570000355	active site
457570000356	FtsH Extracellular; Region: FtsH_ext; pfam06480
457570000357	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
457570000358	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570000359	Walker A motif; other site
457570000360	ATP binding site [chemical binding]; other site
457570000361	Walker B motif; other site
457570000362	arginine finger; other site
457570000363	Peptidase family M41; Region: Peptidase_M41; pfam01434
457570000364	Predicted membrane protein [Function unknown]; Region: COG4684
457570000365	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
457570000366	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
457570000367	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
457570000368	Potassium binding sites [ion binding]; other site
457570000369	Cesium cation binding sites [ion binding]; other site
457570000370	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
457570000371	Biotin operon repressor [Transcription]; Region: BirA; COG1654
457570000372	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
457570000373	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
457570000374	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
457570000375	nucleotide binding site [chemical binding]; other site
457570000376	Type III pantothenate kinase; Region: Pan_kinase; cl17198
457570000377	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
457570000378	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
457570000379	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570000380	putative active site [active]
457570000381	heme pocket [chemical binding]; other site
457570000382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570000383	Walker A motif; other site
457570000384	ATP binding site [chemical binding]; other site
457570000385	Walker B motif; other site
457570000386	arginine finger; other site
457570000387	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
457570000388	DRTGG domain; Region: DRTGG; pfam07085
457570000389	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
457570000390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
457570000391	ATP binding site [chemical binding]; other site
457570000392	Mg2+ binding site [ion binding]; other site
457570000393	G-X-G motif; other site
457570000394	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570000395	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
457570000396	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
457570000397	Putative Fe-S cluster; Region: FeS; cl17515
457570000398	DRTGG domain; Region: DRTGG; pfam07085
457570000399	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
457570000400	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
457570000401	active site
457570000402	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
457570000403	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
457570000404	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
457570000405	putative dimer interface [polypeptide binding]; other site
457570000406	[2Fe-2S] cluster binding site [ion binding]; other site
457570000407	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
457570000408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570000409	ATP binding site [chemical binding]; other site
457570000410	Mg2+ binding site [ion binding]; other site
457570000411	G-X-G motif; other site
457570000412	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
457570000413	dimer interface [polypeptide binding]; other site
457570000414	[2Fe-2S] cluster binding site [ion binding]; other site
457570000415	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
457570000416	dimer interface [polypeptide binding]; other site
457570000417	[2Fe-2S] cluster binding site [ion binding]; other site
457570000418	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
457570000419	SLBB domain; Region: SLBB; pfam10531
457570000420	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
457570000421	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
457570000422	4Fe-4S binding domain; Region: Fer4; pfam00037
457570000423	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
457570000424	4Fe-4S binding domain; Region: Fer4; pfam00037
457570000425	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
457570000426	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
457570000427	catalytic loop [active]
457570000428	iron binding site [ion binding]; other site
457570000429	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
457570000430	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570000431	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
457570000432	[4Fe-4S] binding site [ion binding]; other site
457570000433	molybdopterin cofactor binding site; other site
457570000434	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
457570000435	molybdopterin cofactor binding site; other site
457570000436	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
457570000437	Rubredoxin; Region: Rubredoxin; pfam00301
457570000438	iron binding site [ion binding]; other site
457570000439	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
457570000440	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570000441	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
457570000442	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570000443	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
457570000444	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
457570000445	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
457570000446	TrkA-N domain; Region: TrkA_N; pfam02254
457570000447	TrkA-C domain; Region: TrkA_C; pfam02080
457570000448	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
457570000449	tetramer interfaces [polypeptide binding]; other site
457570000450	binuclear metal-binding site [ion binding]; other site
457570000451	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
457570000452	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
457570000453	inhibitor-cofactor binding pocket; inhibition site
457570000454	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570000455	catalytic residue [active]
457570000456	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
457570000457	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
457570000458	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
457570000459	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
457570000460	trimer interface [polypeptide binding]; other site
457570000461	putative metal binding site [ion binding]; other site
457570000462	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
457570000463	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
457570000464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
457570000465	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
457570000466	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
457570000467	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
457570000468	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
457570000469	FMN binding site [chemical binding]; other site
457570000470	active site
457570000471	catalytic residues [active]
457570000472	substrate binding site [chemical binding]; other site
457570000473	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
457570000474	NAD(P) binding pocket [chemical binding]; other site
457570000475	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
457570000476	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
457570000477	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
457570000478	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
457570000479	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
457570000480	dimer interface [polypeptide binding]; other site
457570000481	putative anticodon binding site; other site
457570000482	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
457570000483	motif 1; other site
457570000484	active site
457570000485	motif 2; other site
457570000486	motif 3; other site
457570000487	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
457570000488	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
457570000489	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
457570000490	Walker A/P-loop; other site
457570000491	ATP binding site [chemical binding]; other site
457570000492	Q-loop/lid; other site
457570000493	ABC transporter signature motif; other site
457570000494	Walker B; other site
457570000495	D-loop; other site
457570000496	H-loop/switch region; other site
457570000497	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
457570000498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570000499	dimer interface [polypeptide binding]; other site
457570000500	conserved gate region; other site
457570000501	putative PBP binding loops; other site
457570000502	ABC-ATPase subunit interface; other site
457570000503	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
457570000504	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
457570000505	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
457570000506	catalytic motif [active]
457570000507	Zn binding site [ion binding]; other site
457570000508	RibD C-terminal domain; Region: RibD_C; cl17279
457570000509	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
457570000510	Lumazine binding domain; Region: Lum_binding; pfam00677
457570000511	Lumazine binding domain; Region: Lum_binding; pfam00677
457570000512	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
457570000513	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
457570000514	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
457570000515	dimerization interface [polypeptide binding]; other site
457570000516	active site
457570000517	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
457570000518	homopentamer interface [polypeptide binding]; other site
457570000519	active site
457570000520	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
457570000521	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570000522	FeS/SAM binding site; other site
457570000523	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
457570000524	ATP cone domain; Region: ATP-cone; pfam03477
457570000525	Class III ribonucleotide reductase; Region: RNR_III; cd01675
457570000526	effector binding site; other site
457570000527	active site
457570000528	Zn binding site [ion binding]; other site
457570000529	glycine loop; other site
457570000530	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
457570000531	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
457570000532	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
457570000533	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
457570000534	active site
457570000535	Zn binding site [ion binding]; other site
457570000536	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
457570000537	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570000538	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570000539	DNA binding residues [nucleotide binding]
457570000540	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
457570000541	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
457570000542	Uncharacterized conserved protein [Function unknown]; Region: COG1739
457570000543	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
457570000544	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
457570000545	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
457570000546	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
457570000547	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570000548	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
457570000549	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
457570000550	catalytic residues [active]
457570000551	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
457570000552	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
457570000553	putative DNA binding site [nucleotide binding]; other site
457570000554	putative homodimer interface [polypeptide binding]; other site
457570000555	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
457570000556	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
457570000557	active site
457570000558	DNA binding site [nucleotide binding]
457570000559	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
457570000560	DNA binding site [nucleotide binding]
457570000561	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
457570000562	nucleotide binding site [chemical binding]; other site
457570000563	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
457570000564	MgtC family; Region: MgtC; pfam02308
457570000565	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
457570000566	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570000567	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570000568	putative active site [active]
457570000569	putative NTP binding site [chemical binding]; other site
457570000570	putative nucleic acid binding site [nucleotide binding]; other site
457570000571	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570000572	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
457570000573	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
457570000574	UvrB/uvrC motif; Region: UVR; pfam02151
457570000575	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
457570000576	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
457570000577	ADP binding site [chemical binding]; other site
457570000578	phosphagen binding site; other site
457570000579	substrate specificity loop; other site
457570000580	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
457570000581	Clp amino terminal domain; Region: Clp_N; pfam02861
457570000582	Clp amino terminal domain; Region: Clp_N; pfam02861
457570000583	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570000584	Walker A motif; other site
457570000585	ATP binding site [chemical binding]; other site
457570000586	Walker B motif; other site
457570000587	arginine finger; other site
457570000588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570000589	Walker A motif; other site
457570000590	ATP binding site [chemical binding]; other site
457570000591	Walker B motif; other site
457570000592	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
457570000593	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
457570000594	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
457570000595	generic binding surface II; other site
457570000596	generic binding surface I; other site
457570000597	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570000598	Zn2+ binding site [ion binding]; other site
457570000599	Mg2+ binding site [ion binding]; other site
457570000600	Protein of unknown function (DUF964); Region: DUF964; pfam06133
457570000601	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
457570000602	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
457570000603	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
457570000604	active site
457570000605	dimer interface [polypeptide binding]; other site
457570000606	effector binding site; other site
457570000607	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
457570000608	TSCPD domain; Region: TSCPD; pfam12637
457570000609	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
457570000610	putative hydrolase; Provisional; Region: PRK02113
457570000611	NAD-dependent deacetylase; Provisional; Region: PRK00481
457570000612	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
457570000613	NAD+ binding site [chemical binding]; other site
457570000614	substrate binding site [chemical binding]; other site
457570000615	Zn binding site [ion binding]; other site
457570000616	Domain of unknown function DUF77; Region: DUF77; pfam01910
457570000617	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570000618	S-adenosylmethionine binding site [chemical binding]; other site
457570000619	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
457570000620	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
457570000621	AP (apurinic/apyrimidinic) site pocket; other site
457570000622	DNA interaction; other site
457570000623	Metal-binding active site; metal-binding site
457570000624	hypothetical protein; Reviewed; Region: PRK09588
457570000625	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
457570000626	Peptidase family M23; Region: Peptidase_M23; pfam01551
457570000627	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
457570000628	DNA repair protein RadA; Provisional; Region: PRK11823
457570000629	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
457570000630	Walker A motif/ATP binding site; other site
457570000631	ATP binding site [chemical binding]; other site
457570000632	Walker B motif; other site
457570000633	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
457570000634	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
457570000635	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
457570000636	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
457570000637	Helix-hairpin-helix motif; Region: HHH; pfam00633
457570000638	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
457570000639	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
457570000640	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570000641	dimer interface [polypeptide binding]; other site
457570000642	putative CheW interface [polypeptide binding]; other site
457570000643	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
457570000644	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
457570000645	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
457570000646	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
457570000647	putative active site [active]
457570000648	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
457570000649	substrate binding site; other site
457570000650	dimer interface; other site
457570000651	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
457570000652	homotrimer interaction site [polypeptide binding]; other site
457570000653	zinc binding site [ion binding]; other site
457570000654	CDP-binding sites; other site
457570000655	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
457570000656	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
457570000657	active site
457570000658	HIGH motif; other site
457570000659	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
457570000660	active site
457570000661	KMSKS motif; other site
457570000662	T-box leader as predicted by Rfam (RF00230), score 67.20; T-box leader sequence
457570000663	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570000664	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570000665	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570000666	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
457570000667	serine O-acetyltransferase; Region: cysE; TIGR01172
457570000668	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
457570000669	trimer interface [polypeptide binding]; other site
457570000670	active site
457570000671	substrate binding site [chemical binding]; other site
457570000672	CoA binding site [chemical binding]; other site
457570000673	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
457570000674	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
457570000675	active site
457570000676	HIGH motif; other site
457570000677	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
457570000678	KMSKS motif; other site
457570000679	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
457570000680	tRNA binding surface [nucleotide binding]; other site
457570000681	anticodon binding site; other site
457570000682	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
457570000683	dimerization interface [polypeptide binding]; other site
457570000684	active site
457570000685	metal binding site [ion binding]; metal-binding site
457570000686	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
457570000687	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
457570000688	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
457570000689	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
457570000690	YacP-like NYN domain; Region: NYN_YacP; pfam05991
457570000691	RNA polymerase factor sigma-70; Validated; Region: PRK08295
457570000692	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570000693	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
457570000694	elongation factor Tu; Reviewed; Region: PRK00049
457570000695	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
457570000696	G1 box; other site
457570000697	GEF interaction site [polypeptide binding]; other site
457570000698	GTP/Mg2+ binding site [chemical binding]; other site
457570000699	Switch I region; other site
457570000700	G2 box; other site
457570000701	G3 box; other site
457570000702	Switch II region; other site
457570000703	G4 box; other site
457570000704	G5 box; other site
457570000705	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
457570000706	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
457570000707	Antibiotic Binding Site [chemical binding]; other site
457570000708	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
457570000709	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
457570000710	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
457570000711	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
457570000712	putative homodimer interface [polypeptide binding]; other site
457570000713	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
457570000714	heterodimer interface [polypeptide binding]; other site
457570000715	homodimer interface [polypeptide binding]; other site
457570000716	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
457570000717	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
457570000718	23S rRNA interface [nucleotide binding]; other site
457570000719	L7/L12 interface [polypeptide binding]; other site
457570000720	putative thiostrepton binding site; other site
457570000721	L25 interface [polypeptide binding]; other site
457570000722	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
457570000723	mRNA/rRNA interface [nucleotide binding]; other site
457570000724	Ribosomal protein L10 leader as predicted by Rfam (RF00557), score 66.44; ribosomal protein L10 leader
457570000725	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
457570000726	23S rRNA interface [nucleotide binding]; other site
457570000727	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
457570000728	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
457570000729	L11 interface [polypeptide binding]; other site
457570000730	putative EF-Tu interaction site [polypeptide binding]; other site
457570000731	putative EF-G interaction site [polypeptide binding]; other site
457570000732	Helix-turn-helix domain; Region: HTH_28; pfam13518
457570000733	Winged helix-turn helix; Region: HTH_29; pfam13551
457570000734	Integrase core domain; Region: rve; pfam00665
457570000735	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
457570000736	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
457570000737	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
457570000738	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
457570000739	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
457570000740	RPB10 interaction site [polypeptide binding]; other site
457570000741	RPB1 interaction site [polypeptide binding]; other site
457570000742	RPB11 interaction site [polypeptide binding]; other site
457570000743	RPB3 interaction site [polypeptide binding]; other site
457570000744	RPB12 interaction site [polypeptide binding]; other site
457570000745	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
457570000746	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
457570000747	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
457570000748	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
457570000749	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
457570000750	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
457570000751	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
457570000752	G-loop; other site
457570000753	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
457570000754	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
457570000755	DNA binding site [nucleotide binding]
457570000756	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
457570000757	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
457570000758	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
457570000759	S17 interaction site [polypeptide binding]; other site
457570000760	S8 interaction site; other site
457570000761	16S rRNA interaction site [nucleotide binding]; other site
457570000762	streptomycin interaction site [chemical binding]; other site
457570000763	23S rRNA interaction site [nucleotide binding]; other site
457570000764	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
457570000765	30S ribosomal protein S7; Validated; Region: PRK05302
457570000766	elongation factor G; Reviewed; Region: PRK00007
457570000767	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
457570000768	G1 box; other site
457570000769	putative GEF interaction site [polypeptide binding]; other site
457570000770	GTP/Mg2+ binding site [chemical binding]; other site
457570000771	Switch I region; other site
457570000772	G2 box; other site
457570000773	G3 box; other site
457570000774	Switch II region; other site
457570000775	G4 box; other site
457570000776	G5 box; other site
457570000777	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
457570000778	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
457570000779	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
457570000780	elongation factor Tu; Reviewed; Region: PRK00049
457570000781	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
457570000782	G1 box; other site
457570000783	GEF interaction site [polypeptide binding]; other site
457570000784	GTP/Mg2+ binding site [chemical binding]; other site
457570000785	Switch I region; other site
457570000786	G2 box; other site
457570000787	G3 box; other site
457570000788	Switch II region; other site
457570000789	G4 box; other site
457570000790	G5 box; other site
457570000791	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
457570000792	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
457570000793	Antibiotic Binding Site [chemical binding]; other site
457570000794	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
457570000795	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
457570000796	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
457570000797	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
457570000798	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
457570000799	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
457570000800	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
457570000801	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
457570000802	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
457570000803	putative translocon binding site; other site
457570000804	protein-rRNA interface [nucleotide binding]; other site
457570000805	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
457570000806	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
457570000807	G-X-X-G motif; other site
457570000808	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
457570000809	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
457570000810	23S rRNA interface [nucleotide binding]; other site
457570000811	5S rRNA interface [nucleotide binding]; other site
457570000812	putative antibiotic binding site [chemical binding]; other site
457570000813	L25 interface [polypeptide binding]; other site
457570000814	L27 interface [polypeptide binding]; other site
457570000815	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
457570000816	23S rRNA interface [nucleotide binding]; other site
457570000817	putative translocon interaction site; other site
457570000818	signal recognition particle (SRP54) interaction site; other site
457570000819	L23 interface [polypeptide binding]; other site
457570000820	trigger factor interaction site; other site
457570000821	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
457570000822	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
457570000823	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
457570000824	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
457570000825	RNA binding site [nucleotide binding]; other site
457570000826	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
457570000827	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
457570000828	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
457570000829	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
457570000830	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
457570000831	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
457570000832	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
457570000833	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
457570000834	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
457570000835	23S rRNA interface [nucleotide binding]; other site
457570000836	5S rRNA interface [nucleotide binding]; other site
457570000837	L27 interface [polypeptide binding]; other site
457570000838	L5 interface [polypeptide binding]; other site
457570000839	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
457570000840	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
457570000841	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
457570000842	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
457570000843	23S rRNA binding site [nucleotide binding]; other site
457570000844	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
457570000845	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
457570000846	SecY translocase; Region: SecY; pfam00344
457570000847	adenylate kinase; Reviewed; Region: adk; PRK00279
457570000848	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
457570000849	AMP-binding site [chemical binding]; other site
457570000850	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
457570000851	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
457570000852	active site
457570000853	50S ribosomal protein L14e; Validated; Region: PRK04333
457570000854	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
457570000855	RNA binding site [nucleotide binding]; other site
457570000856	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
457570000857	rRNA binding site [nucleotide binding]; other site
457570000858	predicted 30S ribosome binding site; other site
457570000859	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
457570000860	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
457570000861	30S ribosomal protein S13; Region: bact_S13; TIGR03631
457570000862	30S ribosomal protein S11; Validated; Region: PRK05309
457570000863	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
457570000864	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
457570000865	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
457570000866	RNA binding surface [nucleotide binding]; other site
457570000867	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
457570000868	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
457570000869	alphaNTD - beta interaction site [polypeptide binding]; other site
457570000870	alphaNTD homodimer interface [polypeptide binding]; other site
457570000871	alphaNTD - beta' interaction site [polypeptide binding]; other site
457570000872	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
457570000873	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
457570000874	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
457570000875	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
457570000876	Walker A/P-loop; other site
457570000877	ATP binding site [chemical binding]; other site
457570000878	Q-loop/lid; other site
457570000879	ABC transporter signature motif; other site
457570000880	Walker B; other site
457570000881	D-loop; other site
457570000882	H-loop/switch region; other site
457570000883	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
457570000884	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
457570000885	Walker A/P-loop; other site
457570000886	ATP binding site [chemical binding]; other site
457570000887	Q-loop/lid; other site
457570000888	ABC transporter signature motif; other site
457570000889	Walker B; other site
457570000890	D-loop; other site
457570000891	H-loop/switch region; other site
457570000892	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
457570000893	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
457570000894	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
457570000895	dimerization interface 3.5A [polypeptide binding]; other site
457570000896	active site
457570000897	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
457570000898	23S rRNA interface [nucleotide binding]; other site
457570000899	L3 interface [polypeptide binding]; other site
457570000900	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
457570000901	Chromate transporter; Region: Chromate_transp; pfam02417
457570000902	Chromate transporter; Region: Chromate_transp; pfam02417
457570000903	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
457570000904	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
457570000905	active site
457570000906	metal binding site [ion binding]; metal-binding site
457570000907	Predicted GTPase [General function prediction only]; Region: COG2403
457570000908	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570000909	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570000910	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570000911	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570000912	Arginase family; Region: Arginase; cd09989
457570000913	agmatinase; Region: agmatinase; TIGR01230
457570000914	active site
457570000915	Mn binding site [ion binding]; other site
457570000916	oligomer interface [polypeptide binding]; other site
457570000917	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
457570000918	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
457570000919	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
457570000920	AMMECR1; Region: AMMECR1; pfam01871
457570000921	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
457570000922	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570000923	FeS/SAM binding site; other site
457570000924	Uncharacterized conserved protein [Function unknown]; Region: COG1624
457570000925	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
457570000926	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
457570000927	YbbR-like protein; Region: YbbR; pfam07949
457570000928	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
457570000929	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
457570000930	active site
457570000931	substrate binding site [chemical binding]; other site
457570000932	metal binding site [ion binding]; metal-binding site
457570000933	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570000934	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570000935	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570000936	Integrase core domain; Region: rve; pfam00665
457570000937	Integrase core domain; Region: rve_3; cl15866
457570000938	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
457570000939	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
457570000940	glutaminase active site [active]
457570000941	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
457570000942	dimer interface [polypeptide binding]; other site
457570000943	active site
457570000944	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
457570000945	dimer interface [polypeptide binding]; other site
457570000946	active site
457570000947	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
457570000948	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
457570000949	Integrase core domain; Region: rve; pfam00665
457570000950	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
457570000951	AAA ATPase domain; Region: AAA_16; pfam13191
457570000952	AAA domain; Region: AAA_22; pfam13401
457570000953	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
457570000954	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
457570000955	dimerization interface [polypeptide binding]; other site
457570000956	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
457570000957	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570000958	putative active site [active]
457570000959	heme pocket [chemical binding]; other site
457570000960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
457570000961	dimer interface [polypeptide binding]; other site
457570000962	phosphorylation site [posttranslational modification]
457570000963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570000964	ATP binding site [chemical binding]; other site
457570000965	Mg2+ binding site [ion binding]; other site
457570000966	G-X-G motif; other site
457570000967	Response regulator receiver domain; Region: Response_reg; pfam00072
457570000968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570000969	active site
457570000970	phosphorylation site [posttranslational modification]
457570000971	intermolecular recognition site; other site
457570000972	dimerization interface [polypeptide binding]; other site
457570000973	Response regulator receiver domain; Region: Response_reg; pfam00072
457570000974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570000975	active site
457570000976	phosphorylation site [posttranslational modification]
457570000977	intermolecular recognition site; other site
457570000978	dimerization interface [polypeptide binding]; other site
457570000979	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
457570000980	TPR motif; other site
457570000981	binding surface
457570000982	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
457570000983	TrkA-N domain; Region: TrkA_N; pfam02254
457570000984	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
457570000985	TrkA-N domain; Region: TrkA_N; pfam02254
457570000986	TrkA-C domain; Region: TrkA_C; pfam02080
457570000987	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
457570000988	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
457570000989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570000990	Transposase; Region: HTH_Tnp_1; pfam01527
457570000991	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
457570000992	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570000993	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570000994	DNA binding residues [nucleotide binding]
457570000995	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
457570000996	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570000997	DNA binding residues [nucleotide binding]
457570000998	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
457570000999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570001000	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570001001	helix-hairpin-helix signature motif; other site
457570001002	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
457570001003	Peptidase family M23; Region: Peptidase_M23; pfam01551
457570001004	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
457570001005	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
457570001006	metal binding site [ion binding]; metal-binding site
457570001007	dimer interface [polypeptide binding]; other site
457570001008	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
457570001009	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
457570001010	TraB family; Region: TraB; pfam01963
457570001011	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
457570001012	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
457570001013	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
457570001014	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
457570001015	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
457570001016	dimer interface [polypeptide binding]; other site
457570001017	FMN binding site [chemical binding]; other site
457570001018	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
457570001019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570001020	S-adenosylmethionine binding site [chemical binding]; other site
457570001021	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
457570001022	DNA polymerase IV; Reviewed; Region: PRK03103
457570001023	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
457570001024	active site
457570001025	DNA binding site [nucleotide binding]
457570001026	BioY family; Region: BioY; pfam02632
457570001027	Divergent AAA domain; Region: AAA_4; pfam04326
457570001028	Predicted membrane protein [Function unknown]; Region: COG2311
457570001029	Protein of unknown function (DUF418); Region: DUF418; pfam04235
457570001030	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
457570001031	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
457570001032	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
457570001033	Coenzyme A binding pocket [chemical binding]; other site
457570001034	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
457570001035	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
457570001036	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
457570001037	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
457570001038	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
457570001039	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
457570001040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570001041	homodimer interface [polypeptide binding]; other site
457570001042	catalytic residue [active]
457570001043	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
457570001044	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
457570001045	active site
457570001046	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
457570001047	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
457570001048	substrate-cofactor binding pocket; other site
457570001049	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570001050	catalytic residue [active]
457570001051	Threonine dehydrogenase; Region: TDH; cd05281
457570001052	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
457570001053	structural Zn binding site [ion binding]; other site
457570001054	catalytic Zn binding site [ion binding]; other site
457570001055	tetramer interface [polypeptide binding]; other site
457570001056	NADP binding site [chemical binding]; other site
457570001057	Uncharacterized conserved protein [Function unknown]; Region: COG3937
457570001058	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
457570001059	ABC1 family; Region: ABC1; cl17513
457570001060	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570001061	Zn2+ binding site [ion binding]; other site
457570001062	Mg2+ binding site [ion binding]; other site
457570001063	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570001064	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570001065	Zn2+ binding site [ion binding]; other site
457570001066	Mg2+ binding site [ion binding]; other site
457570001067	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
457570001068	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
457570001069	Ligand binding site; other site
457570001070	Putative Catalytic site; other site
457570001071	DXD motif; other site
457570001072	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
457570001073	glutaminase A; Region: Gln_ase; TIGR03814
457570001074	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
457570001075	Rrf2 family protein; Region: rrf2_super; TIGR00738
457570001076	Transcriptional regulator; Region: Rrf2; cl17282
457570001077	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
457570001078	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
457570001079	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
457570001080	catalytic residue [active]
457570001081	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
457570001082	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
457570001083	trimerization site [polypeptide binding]; other site
457570001084	active site
457570001085	Uncharacterized conserved protein [Function unknown]; Region: COG0062
457570001086	putative carbohydrate kinase; Provisional; Region: PRK10565
457570001087	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
457570001088	putative substrate binding site [chemical binding]; other site
457570001089	putative ATP binding site [chemical binding]; other site
457570001090	FOG: CBS domain [General function prediction only]; Region: COG0517
457570001091	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
457570001092	alanine racemase; Reviewed; Region: alr; PRK00053
457570001093	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
457570001094	active site
457570001095	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
457570001096	dimer interface [polypeptide binding]; other site
457570001097	substrate binding site [chemical binding]; other site
457570001098	catalytic residues [active]
457570001099	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
457570001100	PemK-like protein; Region: PemK; pfam02452
457570001101	D-cysteine desulfhydrase; Validated; Region: PRK03910
457570001102	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
457570001103	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
457570001104	catalytic residue [active]
457570001105	L-asparaginase II; Region: Asparaginase_II; pfam06089
457570001106	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
457570001107	SxDxEG motif; other site
457570001108	active site
457570001109	metal binding site [ion binding]; metal-binding site
457570001110	homopentamer interface [polypeptide binding]; other site
457570001111	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
457570001112	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
457570001113	oligomer interface [polypeptide binding]; other site
457570001114	active site
457570001115	metal binding site [ion binding]; metal-binding site
457570001116	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
457570001117	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570001118	S-adenosylmethionine binding site [chemical binding]; other site
457570001119	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
457570001120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570001121	ATP binding site [chemical binding]; other site
457570001122	Mg2+ binding site [ion binding]; other site
457570001123	G-X-G motif; other site
457570001124	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
457570001125	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
457570001126	Uncharacterized conserved protein [Function unknown]; Region: COG2006
457570001127	Domain of unknown function (DUF362); Region: DUF362; pfam04015
457570001128	4Fe-4S binding domain; Region: Fer4; pfam00037
457570001129	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
457570001130	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
457570001131	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
457570001132	active site
457570001133	catalytic tetrad [active]
457570001134	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570001135	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
457570001136	DNA-binding site [nucleotide binding]; DNA binding site
457570001137	RNA-binding motif; other site
457570001138	Predicted membrane protein [Function unknown]; Region: COG2323
457570001139	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
457570001140	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
457570001141	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
457570001142	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
457570001143	Walker A/P-loop; other site
457570001144	ATP binding site [chemical binding]; other site
457570001145	Q-loop/lid; other site
457570001146	ABC transporter signature motif; other site
457570001147	Walker B; other site
457570001148	D-loop; other site
457570001149	H-loop/switch region; other site
457570001150	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
457570001151	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
457570001152	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
457570001153	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
457570001154	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
457570001155	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
457570001156	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
457570001157	Walker A/P-loop; other site
457570001158	ATP binding site [chemical binding]; other site
457570001159	Q-loop/lid; other site
457570001160	ABC transporter signature motif; other site
457570001161	Walker B; other site
457570001162	D-loop; other site
457570001163	H-loop/switch region; other site
457570001164	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
457570001165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570001166	dimer interface [polypeptide binding]; other site
457570001167	conserved gate region; other site
457570001168	putative PBP binding loops; other site
457570001169	ABC-ATPase subunit interface; other site
457570001170	PBP superfamily domain; Region: PBP_like_2; pfam12849
457570001171	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
457570001172	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
457570001173	Moco binding site; other site
457570001174	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
457570001175	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
457570001176	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
457570001177	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
457570001178	Walker A/P-loop; other site
457570001179	ATP binding site [chemical binding]; other site
457570001180	Q-loop/lid; other site
457570001181	ABC transporter signature motif; other site
457570001182	Walker B; other site
457570001183	D-loop; other site
457570001184	H-loop/switch region; other site
457570001185	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
457570001186	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
457570001187	Walker A/P-loop; other site
457570001188	ATP binding site [chemical binding]; other site
457570001189	Q-loop/lid; other site
457570001190	ABC transporter signature motif; other site
457570001191	Walker B; other site
457570001192	D-loop; other site
457570001193	H-loop/switch region; other site
457570001194	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
457570001195	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494
457570001196	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
457570001197	Putative Fe-S cluster; Region: FeS; cl17515
457570001198	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
457570001199	active site
457570001200	ATP binding site [chemical binding]; other site
457570001201	substrate binding site [chemical binding]; other site
457570001202	TOBE domain; Region: TOBE; cl01440
457570001203	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
457570001204	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
457570001205	Nitrogen regulatory protein P-II; Region: P-II; smart00938
457570001206	Nitrogen regulatory protein P-II; Region: P-II; smart00938
457570001207	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
457570001208	HSP70 interaction site [polypeptide binding]; other site
457570001209	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
457570001210	EamA-like transporter family; Region: EamA; pfam00892
457570001211	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
457570001212	EamA-like transporter family; Region: EamA; pfam00892
457570001213	EamA-like transporter family; Region: EamA; pfam00892
457570001214	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
457570001215	EamA-like transporter family; Region: EamA; pfam00892
457570001216	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
457570001217	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
457570001218	Walker A/P-loop; other site
457570001219	ATP binding site [chemical binding]; other site
457570001220	Q-loop/lid; other site
457570001221	Walker B; other site
457570001222	D-loop; other site
457570001223	H-loop/switch region; other site
457570001224	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
457570001225	active site
457570001226	NodB motif; other site
457570001227	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
457570001228	Right handed beta helix region; Region: Beta_helix; pfam13229
457570001229	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
457570001230	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
457570001231	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
457570001232	Mg binding site [ion binding]; other site
457570001233	nucleotide binding site [chemical binding]; other site
457570001234	putative protofilament interface [polypeptide binding]; other site
457570001235	YjcQ protein; Region: YjcQ; pfam09639
457570001236	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
457570001237	putative active site [active]
457570001238	catalytic site [active]
457570001239	DEAD-like helicases superfamily; Region: DEXDc; smart00487
457570001240	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
457570001241	ATP binding site [chemical binding]; other site
457570001242	putative Mg++ binding site [ion binding]; other site
457570001243	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
457570001244	nucleotide binding region [chemical binding]; other site
457570001245	ATP-binding site [chemical binding]; other site
457570001246	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
457570001247	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
457570001248	DNA methylase; Region: N6_N4_Mtase; cl17433
457570001249	DNA methylase; Region: N6_N4_Mtase; pfam01555
457570001250	DNA methylase; Region: N6_N4_Mtase; cl17433
457570001251	Restriction endonuclease [Defense mechanisms]; Region: COG3587
457570001252	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
457570001253	ATP binding site [chemical binding]; other site
457570001254	putative Mg++ binding site [ion binding]; other site
457570001255	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570001256	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
457570001257	Protein of unknown function DUF91; Region: DUF91; cl00709
457570001258	precorrin-2 dehydrogenase; Provisional; Region: PRK05562
457570001259	60S ribosomal protein L37a; Provisional; Region: PTZ00255; cl00875
457570001260	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570001261	sequence-specific DNA binding site [nucleotide binding]; other site
457570001262	salt bridge; other site
457570001263	Phage integrase family; Region: Phage_integrase; pfam00589
457570001264	active site
457570001265	DNA binding site [nucleotide binding]
457570001266	Int/Topo IB signature motif; other site
457570001267	Transposase, Mutator family; Region: Transposase_mut; pfam00872
457570001268	MULE transposase domain; Region: MULE; pfam10551
457570001269	Helix-turn-helix domain; Region: HTH_28; pfam13518
457570001270	Winged helix-turn helix; Region: HTH_29; pfam13551
457570001271	Integrase core domain; Region: rve; pfam00665
457570001272	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
457570001273	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
457570001274	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
457570001275	catalytic residues [active]
457570001276	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
457570001277	catalytic nucleophile [active]
457570001278	Recombinase; Region: Recombinase; pfam07508
457570001279	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
457570001280	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
457570001281	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
457570001282	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
457570001283	PRC-barrel domain; Region: PRC; pfam05239
457570001284	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
457570001285	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
457570001286	Glycoprotease family; Region: Peptidase_M22; pfam00814
457570001287	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
457570001288	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
457570001289	Coenzyme A binding pocket [chemical binding]; other site
457570001290	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
457570001291	UGMP family protein; Validated; Region: PRK09604
457570001292	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
457570001293	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
457570001294	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
457570001295	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
457570001296	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
457570001297	Radical SAM superfamily; Region: Radical_SAM; pfam04055
457570001298	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570001299	FeS/SAM binding site; other site
457570001300	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
457570001301	Protein of unknown function (DUF512); Region: DUF512; pfam04459
457570001302	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
457570001303	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
457570001304	Predicted integral membrane protein [Function unknown]; Region: COG5617
457570001305	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
457570001306	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570001307	Walker A/P-loop; other site
457570001308	ATP binding site [chemical binding]; other site
457570001309	Q-loop/lid; other site
457570001310	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
457570001311	ABC transporter signature motif; other site
457570001312	Walker B; other site
457570001313	D-loop; other site
457570001314	ABC transporter; Region: ABC_tran_2; pfam12848
457570001315	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
457570001316	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
457570001317	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
457570001318	ATP binding site [chemical binding]; other site
457570001319	substrate interface [chemical binding]; other site
457570001320	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
457570001321	Mechanosensitive ion channel; Region: MS_channel; pfam00924
457570001322	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
457570001323	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
457570001324	TPP-binding site [chemical binding]; other site
457570001325	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
457570001326	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
457570001327	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
457570001328	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
457570001329	dimer interface [polypeptide binding]; other site
457570001330	PYR/PP interface [polypeptide binding]; other site
457570001331	TPP binding site [chemical binding]; other site
457570001332	substrate binding site [chemical binding]; other site
457570001333	Isopentenyl transferase; Region: IPT; pfam01745
457570001334	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
457570001335	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
457570001336	Ligand Binding Site [chemical binding]; other site
457570001337	TIGR00269 family protein; Region: TIGR00269
457570001338	Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104
457570001339	charged pocket; other site
457570001340	hydrophobic patch; other site
457570001341	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
457570001342	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
457570001343	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
457570001344	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
457570001345	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
457570001346	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
457570001347	ligand binding site [chemical binding]; other site
457570001348	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
457570001349	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570001350	Walker A/P-loop; other site
457570001351	ATP binding site [chemical binding]; other site
457570001352	Q-loop/lid; other site
457570001353	ABC transporter signature motif; other site
457570001354	Walker B; other site
457570001355	D-loop; other site
457570001356	H-loop/switch region; other site
457570001357	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
457570001358	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
457570001359	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
457570001360	TM-ABC transporter signature motif; other site
457570001361	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
457570001362	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
457570001363	TM-ABC transporter signature motif; other site
457570001364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570001365	putative substrate translocation pore; other site
457570001366	Major Facilitator Superfamily; Region: MFS_1; pfam07690
457570001367	Predicted membrane protein [Function unknown]; Region: COG2364
457570001368	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
457570001369	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
457570001370	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
457570001371	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
457570001372	active site
457570001373	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
457570001374	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
457570001375	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570001376	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
457570001377	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
457570001378	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
457570001379	putative lipid kinase; Reviewed; Region: PRK13059
457570001380	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
457570001381	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
457570001382	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
457570001383	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570001384	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
457570001385	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
457570001386	active site
457570001387	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
457570001388	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u3_5s; cd10972
457570001389	putative active site [active]
457570001390	putative metal binding site [ion binding]; other site
457570001391	T-box leader as predicted by Rfam (RF00230), score 64.50; T-box leader sequence
457570001392	prolyl-tRNA synthetase; Provisional; Region: PRK08661
457570001393	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
457570001394	dimer interface [polypeptide binding]; other site
457570001395	motif 1; other site
457570001396	active site
457570001397	motif 2; other site
457570001398	motif 3; other site
457570001399	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
457570001400	anticodon binding site; other site
457570001401	zinc-binding site [ion binding]; other site
457570001402	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
457570001403	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
457570001404	Protein of unknown function (DUF401); Region: DUF401; cl00830
457570001405	MoxR-like ATPases [General function prediction only]; Region: COG0714
457570001406	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570001407	Walker A motif; other site
457570001408	ATP binding site [chemical binding]; other site
457570001409	Walker B motif; other site
457570001410	arginine finger; other site
457570001411	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
457570001412	Protein of unknown function DUF58; Region: DUF58; pfam01882
457570001413	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
457570001414	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
457570001415	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
457570001416	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
457570001417	Nuclease-related domain; Region: NERD; pfam08378
457570001418	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
457570001419	PBP superfamily domain; Region: PBP_like_2; pfam12849
457570001420	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
457570001421	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
457570001422	active site
457570001423	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
457570001424	Ligand Binding Site [chemical binding]; other site
457570001425	Molecular Tunnel; other site
457570001426	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
457570001427	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
457570001428	dimer interface [polypeptide binding]; other site
457570001429	putative functional site; other site
457570001430	putative MPT binding site; other site
457570001431	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
457570001432	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
457570001433	dimer interface [polypeptide binding]; other site
457570001434	putative functional site; other site
457570001435	putative MPT binding site; other site
457570001436	PBP superfamily domain; Region: PBP_like; pfam12727
457570001437	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
457570001438	MPT binding site; other site
457570001439	trimer interface [polypeptide binding]; other site
457570001440	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
457570001441	oligomerisation interface [polypeptide binding]; other site
457570001442	mobile loop; other site
457570001443	roof hairpin; other site
457570001444	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
457570001445	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
457570001446	ring oligomerisation interface [polypeptide binding]; other site
457570001447	ATP/Mg binding site [chemical binding]; other site
457570001448	stacking interactions; other site
457570001449	hinge regions; other site
457570001450	Tetratricopeptide repeat; Region: TPR_12; pfam13424
457570001451	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
457570001452	TPR motif; other site
457570001453	binding surface
457570001454	Tetratricopeptide repeat; Region: TPR_16; pfam13432
457570001455	GMP synthase; Reviewed; Region: guaA; PRK00074
457570001456	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
457570001457	AMP/PPi binding site [chemical binding]; other site
457570001458	candidate oxyanion hole; other site
457570001459	catalytic triad [active]
457570001460	potential glutamine specificity residues [chemical binding]; other site
457570001461	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
457570001462	ATP Binding subdomain [chemical binding]; other site
457570001463	Ligand Binding sites [chemical binding]; other site
457570001464	Dimerization subdomain; other site
457570001465	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
457570001466	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
457570001467	NAD binding site [chemical binding]; other site
457570001468	ATP-grasp domain; Region: ATP-grasp; pfam02222
457570001469	AIR carboxylase; Region: AIRC; pfam00731
457570001470	adenylosuccinate lyase; Provisional; Region: PRK07492
457570001471	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
457570001472	tetramer interface [polypeptide binding]; other site
457570001473	active site
457570001474	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
457570001475	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
457570001476	dimerization interface [polypeptide binding]; other site
457570001477	putative ATP binding site [chemical binding]; other site
457570001478	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
457570001479	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
457570001480	active site
457570001481	substrate binding site [chemical binding]; other site
457570001482	cosubstrate binding site; other site
457570001483	catalytic site [active]
457570001484	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
457570001485	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
457570001486	purine monophosphate binding site [chemical binding]; other site
457570001487	dimer interface [polypeptide binding]; other site
457570001488	putative catalytic residues [active]
457570001489	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
457570001490	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
457570001491	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
457570001492	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
457570001493	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
457570001494	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
457570001495	Trp repressor protein; Region: Trp_repressor; cl17266
457570001496	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
457570001497	Part of AAA domain; Region: AAA_19; pfam13245
457570001498	Family description; Region: UvrD_C_2; pfam13538
457570001499	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
457570001500	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
457570001501	nucleotide binding pocket [chemical binding]; other site
457570001502	K-X-D-G motif; other site
457570001503	catalytic site [active]
457570001504	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
457570001505	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
457570001506	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
457570001507	Dimer interface [polypeptide binding]; other site
457570001508	BRCT sequence motif; other site
457570001509	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
457570001510	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
457570001511	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
457570001512	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
457570001513	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
457570001514	GatB domain; Region: GatB_Yqey; smart00845
457570001515	Protein of unknown function (DUF401); Region: DUF401; cl00830
457570001516	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
457570001517	TRAM domain; Region: TRAM; pfam01938
457570001518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570001519	S-adenosylmethionine binding site [chemical binding]; other site
457570001520	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
457570001521	putative active site [active]
457570001522	putative CoA binding site [chemical binding]; other site
457570001523	nudix motif; other site
457570001524	metal binding site [ion binding]; metal-binding site
457570001525	Domain of unknown function (DUF362); Region: DUF362; pfam04015
457570001526	Uncharacterized conserved protein [Function unknown]; Region: COG2006
457570001527	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
457570001528	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
457570001529	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570001530	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
457570001531	catalytic residues [active]
457570001532	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
457570001533	catalytic residues [active]
457570001534	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
457570001535	glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265
457570001536	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
457570001537	selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918
457570001538	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
457570001539	active site
457570001540	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
457570001541	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570001542	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
457570001543	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
457570001544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570001545	dimer interface [polypeptide binding]; other site
457570001546	conserved gate region; other site
457570001547	putative PBP binding loops; other site
457570001548	ABC-ATPase subunit interface; other site
457570001549	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
457570001550	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
457570001551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570001552	dimer interface [polypeptide binding]; other site
457570001553	conserved gate region; other site
457570001554	putative PBP binding loops; other site
457570001555	ABC-ATPase subunit interface; other site
457570001556	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
457570001557	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570001558	Walker A/P-loop; other site
457570001559	ATP binding site [chemical binding]; other site
457570001560	Q-loop/lid; other site
457570001561	ABC transporter signature motif; other site
457570001562	Walker B; other site
457570001563	D-loop; other site
457570001564	H-loop/switch region; other site
457570001565	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570001566	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
457570001567	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570001568	Walker A/P-loop; other site
457570001569	ATP binding site [chemical binding]; other site
457570001570	Q-loop/lid; other site
457570001571	ABC transporter signature motif; other site
457570001572	Walker B; other site
457570001573	D-loop; other site
457570001574	H-loop/switch region; other site
457570001575	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570001576	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
457570001577	Fe-S cluster binding site [ion binding]; other site
457570001578	active site
457570001579	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
457570001580	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
457570001581	Uncharacterized conserved protein [Function unknown]; Region: COG2155
457570001582	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
457570001583	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
457570001584	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
457570001585	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
457570001586	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570001587	Bacterial SH3 domain; Region: SH3_3; cl17532
457570001588	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
457570001589	active site
457570001590	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
457570001591	4Fe-4S binding domain; Region: Fer4; cl02805
457570001592	Cation efflux family; Region: Cation_efflux; cl00316
457570001593	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
457570001594	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
457570001595	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
457570001596	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
457570001597	minor groove reading motif; other site
457570001598	helix-hairpin-helix signature motif; other site
457570001599	substrate binding pocket [chemical binding]; other site
457570001600	active site
457570001601	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
457570001602	epoxyqueuosine reductase; Region: TIGR00276
457570001603	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
457570001604	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
457570001605	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
457570001606	lipoyl-biotinyl attachment site [posttranslational modification]; other site
457570001607	SLBB domain; Region: SLBB; pfam10531
457570001608	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570001609	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
457570001610	FMN-binding domain; Region: FMN_bind; cl01081
457570001611	electron transport complex RsxE subunit; Provisional; Region: PRK12405
457570001612	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
457570001613	ferredoxin; Provisional; Region: PRK08764
457570001614	Putative Fe-S cluster; Region: FeS; cl17515
457570001615	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
457570001616	trimer interface [polypeptide binding]; other site
457570001617	dimer interface [polypeptide binding]; other site
457570001618	putative active site [active]
457570001619	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
457570001620	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
457570001621	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
457570001622	hypothetical protein; Provisional; Region: PRK08378
457570001623	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
457570001624	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
457570001625	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
457570001626	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
457570001627	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
457570001628	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08376
457570001629	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
457570001630	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
457570001631	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
457570001632	ApbE family; Region: ApbE; pfam02424
457570001633	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
457570001634	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
457570001635	Maf-like protein; Reviewed; Region: PRK00078
457570001636	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
457570001637	active site
457570001638	dimer interface [polypeptide binding]; other site
457570001639	hypothetical protein; Reviewed; Region: PRK00024
457570001640	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
457570001641	MPN+ (JAMM) motif; other site
457570001642	Zinc-binding site [ion binding]; other site
457570001643	rod shape-determining protein MreB; Provisional; Region: PRK13927
457570001644	MreB and similar proteins; Region: MreB_like; cd10225
457570001645	nucleotide binding site [chemical binding]; other site
457570001646	Mg binding site [ion binding]; other site
457570001647	putative protofilament interaction site [polypeptide binding]; other site
457570001648	RodZ interaction site [polypeptide binding]; other site
457570001649	rod shape-determining protein MreC; Provisional; Region: PRK13922
457570001650	rod shape-determining protein MreC; Region: MreC; pfam04085
457570001651	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
457570001652	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
457570001653	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
457570001654	septum formation inhibitor; Reviewed; Region: minC; PRK00513
457570001655	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
457570001656	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
457570001657	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
457570001658	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
457570001659	Switch I; other site
457570001660	Switch II; other site
457570001661	Septum formation topological specificity factor MinE; Region: MinE; cl00538
457570001662	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
457570001663	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
457570001664	Peptidase family M50; Region: Peptidase_M50; pfam02163
457570001665	active site
457570001666	putative substrate binding region [chemical binding]; other site
457570001667	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
457570001668	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
457570001669	B12 binding site [chemical binding]; other site
457570001670	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570001671	FeS/SAM binding site; other site
457570001672	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
457570001673	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
457570001674	Helix-turn-helix domain; Region: HTH_28; pfam13518
457570001675	Winged helix-turn helix; Region: HTH_29; pfam13551
457570001676	Integrase core domain; Region: rve; pfam00665
457570001677	Ribosomal protein L21 leader as predicted by Rfam (RF00559), score 30.65; ribosomal protein L21 leader
457570001678	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
457570001679	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
457570001680	Protein of unknown function (DUF464); Region: DUF464; pfam04327
457570001681	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
457570001682	GTPase CgtA; Reviewed; Region: obgE; PRK12297
457570001683	GTP1/OBG; Region: GTP1_OBG; pfam01018
457570001684	Obg GTPase; Region: Obg; cd01898
457570001685	G1 box; other site
457570001686	GTP/Mg2+ binding site [chemical binding]; other site
457570001687	Switch I region; other site
457570001688	G2 box; other site
457570001689	G3 box; other site
457570001690	Switch II region; other site
457570001691	G4 box; other site
457570001692	G5 box; other site
457570001693	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
457570001694	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
457570001695	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
457570001696	active site
457570001697	(T/H)XGH motif; other site
457570001698	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570001699	Zn2+ binding site [ion binding]; other site
457570001700	Mg2+ binding site [ion binding]; other site
457570001701	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
457570001702	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
457570001703	T-box leader as predicted by Rfam (RF00230), score 104.13; T-box leader sequence
457570001704	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
457570001705	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
457570001706	HIGH motif; other site
457570001707	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
457570001708	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
457570001709	active site
457570001710	KMSKS motif; other site
457570001711	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
457570001712	tRNA binding surface [nucleotide binding]; other site
457570001713	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
457570001714	4Fe-4S binding domain; Region: Fer4; pfam00037
457570001715	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
457570001716	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
457570001717	SLBB domain; Region: SLBB; pfam10531
457570001718	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570001719	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
457570001720	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
457570001721	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
457570001722	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
457570001723	motif II; other site
457570001724	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
457570001725	metal binding site 2 [ion binding]; metal-binding site
457570001726	putative DNA binding helix; other site
457570001727	metal binding site 1 [ion binding]; metal-binding site
457570001728	dimer interface [polypeptide binding]; other site
457570001729	structural Zn2+ binding site [ion binding]; other site
457570001730	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
457570001731	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
457570001732	tetramer interface [polypeptide binding]; other site
457570001733	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570001734	catalytic residue [active]
457570001735	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
457570001736	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
457570001737	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
457570001738	DNA-binding site [nucleotide binding]; DNA binding site
457570001739	DRTGG domain; Region: DRTGG; pfam07085
457570001740	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
457570001741	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
457570001742	active site 2 [active]
457570001743	active site 1 [active]
457570001744	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
457570001745	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
457570001746	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
457570001747	active site
457570001748	PHP Thumb interface [polypeptide binding]; other site
457570001749	metal binding site [ion binding]; metal-binding site
457570001750	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
457570001751	generic binding surface II; other site
457570001752	generic binding surface I; other site
457570001753	pyruvate kinase; Provisional; Region: PRK06354
457570001754	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
457570001755	domain interfaces; other site
457570001756	active site
457570001757	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
457570001758	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
457570001759	active site
457570001760	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
457570001761	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
457570001762	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
457570001763	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570001764	FeS/SAM binding site; other site
457570001765	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
457570001766	putative bifunctional 4-alpha-glucanotransferase/glycogen debranching enzyme; Provisional; Region: PRK14510
457570001767	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
457570001768	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
457570001769	active site
457570001770	homodimer interface [polypeptide binding]; other site
457570001771	catalytic site [active]
457570001772	4-alpha-glucanotransferase; Provisional; Region: PRK14508
457570001773	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
457570001774	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
457570001775	active site pocket [active]
457570001776	glycogen synthase; Provisional; Region: glgA; PRK00654
457570001777	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
457570001778	ADP-binding pocket [chemical binding]; other site
457570001779	homodimer interface [polypeptide binding]; other site
457570001780	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
457570001781	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
457570001782	active site
457570001783	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
457570001784	dimer interface [polypeptide binding]; other site
457570001785	N-terminal domain interface [polypeptide binding]; other site
457570001786	sulfate 1 binding site; other site
457570001787	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
457570001788	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
457570001789	ligand binding site; other site
457570001790	oligomer interface; other site
457570001791	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
457570001792	dimer interface [polypeptide binding]; other site
457570001793	N-terminal domain interface [polypeptide binding]; other site
457570001794	sulfate 1 binding site; other site
457570001795	glycogen branching enzyme; Provisional; Region: PRK12313
457570001796	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
457570001797	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
457570001798	active site
457570001799	catalytic site [active]
457570001800	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
457570001801	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
457570001802	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
457570001803	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
457570001804	active site
457570001805	catalytic tetrad [active]
457570001806	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
457570001807	Coenzyme A binding pocket [chemical binding]; other site
457570001808	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
457570001809	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
457570001810	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
457570001811	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
457570001812	Walker A/P-loop; other site
457570001813	ATP binding site [chemical binding]; other site
457570001814	Q-loop/lid; other site
457570001815	ABC transporter signature motif; other site
457570001816	Walker B; other site
457570001817	D-loop; other site
457570001818	H-loop/switch region; other site
457570001819	Uncharacterized conserved protein [Function unknown]; Region: COG2006
457570001820	Domain of unknown function (DUF362); Region: DUF362; pfam04015
457570001821	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
457570001822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
457570001823	motif II; other site
457570001824	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
457570001825	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
457570001826	Putative glycosyl hydrolase domain; Region: DUF4015; cl17870
457570001827	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
457570001828	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
457570001829	active site
457570001830	HIGH motif; other site
457570001831	dimer interface [polypeptide binding]; other site
457570001832	KMSKS motif; other site
457570001833	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
457570001834	putative FMN binding site [chemical binding]; other site
457570001835	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
457570001836	active site
457570001837	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
457570001838	catalytic tetrad [active]
457570001839	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
457570001840	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
457570001841	putative dimer interface [polypeptide binding]; other site
457570001842	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
457570001843	putative active site [active]
457570001844	GIY-YIG motif/motif A; other site
457570001845	putative metal binding site [ion binding]; other site
457570001846	HD domain; Region: HD_3; pfam13023
457570001847	CAAX protease self-immunity; Region: Abi; pfam02517
457570001848	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
457570001849	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
457570001850	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570001851	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
457570001852	Uncharacterized conserved protein [Function unknown]; Region: COG1633
457570001853	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
457570001854	diiron binding motif [ion binding]; other site
457570001855	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570001856	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570001857	putative active site [active]
457570001858	putative NTP binding site [chemical binding]; other site
457570001859	putative nucleic acid binding site [nucleotide binding]; other site
457570001860	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570001861	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
457570001862	putative dimer interface [polypeptide binding]; other site
457570001863	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
457570001864	putative FMN binding site [chemical binding]; other site
457570001865	NADPH bind site [chemical binding]; other site
457570001866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
457570001867	Coenzyme A binding pocket [chemical binding]; other site
457570001868	Sterol carrier protein domain; Region: SCP2_2; pfam13530
457570001869	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
457570001870	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
457570001871	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570001872	Walker A/P-loop; other site
457570001873	ATP binding site [chemical binding]; other site
457570001874	Q-loop/lid; other site
457570001875	ABC transporter signature motif; other site
457570001876	Walker B; other site
457570001877	D-loop; other site
457570001878	H-loop/switch region; other site
457570001879	Methyltransferase domain; Region: Methyltransf_25; pfam13649
457570001880	hypothetical protein; Provisional; Region: PRK13690
457570001881	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
457570001882	active site
457570001883	substrate binding site [chemical binding]; other site
457570001884	catalytic site [active]
457570001885	Predicted membrane protein [Function unknown]; Region: COG1971
457570001886	VanW like protein; Region: VanW; pfam04294
457570001887	BCCT family transporter; Region: BCCT; pfam02028
457570001888	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
457570001889	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
457570001890	Spore germination protein; Region: Spore_permease; cl17796
457570001891	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
457570001892	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
457570001893	hydroxyglutarate oxidase; Provisional; Region: PRK11728
457570001894	Isochorismatase family; Region: Isochorismatase; pfam00857
457570001895	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
457570001896	catalytic triad [active]
457570001897	conserved cis-peptide bond; other site
457570001898	Predicted membrane protein [Function unknown]; Region: COG3601
457570001899	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
457570001900	BCCT family transporter; Region: BCCT; pfam02028
457570001901	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
457570001902	Ligand Binding Site [chemical binding]; other site
457570001903	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
457570001904	Ligand Binding Site [chemical binding]; other site
457570001905	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
457570001906	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
457570001907	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
457570001908	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
457570001909	RNA binding site [nucleotide binding]; other site
457570001910	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295
457570001911	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
457570001912	Smr domain; Region: Smr; pfam01713
457570001913	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
457570001914	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
457570001915	metal binding site [ion binding]; metal-binding site
457570001916	dimer interface [polypeptide binding]; other site
457570001917	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
457570001918	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
457570001919	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
457570001920	active site
457570001921	metal binding site [ion binding]; metal-binding site
457570001922	Der1-like family; Region: DER1; cl17806
457570001923	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
457570001924	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
457570001925	amidohydrolase; Region: amidohydrolases; TIGR01891
457570001926	metal binding site [ion binding]; metal-binding site
457570001927	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
457570001928	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
457570001929	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
457570001930	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
457570001931	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570001932	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570001933	putative active site [active]
457570001934	putative NTP binding site [chemical binding]; other site
457570001935	putative nucleic acid binding site [nucleotide binding]; other site
457570001936	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570001937	Protein of unknown function, DUF488; Region: DUF488; pfam04343
457570001938	Thiamine pyrophosphokinase; Region: TPK; cd07995
457570001939	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
457570001940	active site
457570001941	dimerization interface [polypeptide binding]; other site
457570001942	thiamine binding site [chemical binding]; other site
457570001943	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
457570001944	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
457570001945	aspartate racemase; Region: asp_race; TIGR00035
457570001946	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
457570001947	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
457570001948	homodimer interface [polypeptide binding]; other site
457570001949	substrate-cofactor binding pocket; other site
457570001950	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570001951	catalytic residue [active]
457570001952	oxaloacetate decarboxylase; Provisional; Region: PRK12331
457570001953	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
457570001954	active site
457570001955	catalytic residues [active]
457570001956	metal binding site [ion binding]; metal-binding site
457570001957	homodimer binding site [polypeptide binding]; other site
457570001958	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
457570001959	carboxyltransferase (CT) interaction site; other site
457570001960	biotinylation site [posttranslational modification]; other site
457570001961	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
457570001962	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
457570001963	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
457570001964	Hemerythrin; Region: Hemerythrin; cd12107
457570001965	Fe binding site [ion binding]; other site
457570001966	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
457570001967	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
457570001968	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
457570001969	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
457570001970	putative active site [active]
457570001971	catalytic site [active]
457570001972	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
457570001973	putative active site [active]
457570001974	catalytic site [active]
457570001975	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
457570001976	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
457570001977	catalytic residue [active]
457570001978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570001979	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
457570001980	Walker A motif; other site
457570001981	ATP binding site [chemical binding]; other site
457570001982	Walker B motif; other site
457570001983	arginine finger; other site
457570001984	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
457570001985	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
457570001986	active site
457570001987	metal binding site [ion binding]; metal-binding site
457570001988	homotetramer interface [polypeptide binding]; other site
457570001989	PrcB C-terminal; Region: PrcB_C; pfam14343
457570001990	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
457570001991	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
457570001992	molybdopterin cofactor binding site; other site
457570001993	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
457570001994	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
457570001995	putative molybdopterin cofactor binding site; other site
457570001996	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
457570001997	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
457570001998	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
457570001999	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
457570002000	dimer interface [polypeptide binding]; other site
457570002001	putative functional site; other site
457570002002	putative MPT binding site; other site
457570002003	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
457570002004	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
457570002005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570002006	active site
457570002007	phosphorylation site [posttranslational modification]
457570002008	intermolecular recognition site; other site
457570002009	dimerization interface [polypeptide binding]; other site
457570002010	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
457570002011	DNA binding residues [nucleotide binding]
457570002012	dimerization interface [polypeptide binding]; other site
457570002013	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
457570002014	dimerization interface [polypeptide binding]; other site
457570002015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
457570002016	Histidine kinase; Region: HisKA_3; pfam07730
457570002017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570002018	ATP binding site [chemical binding]; other site
457570002019	Mg2+ binding site [ion binding]; other site
457570002020	G-X-G motif; other site
457570002021	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
457570002022	FMN-binding domain; Region: FMN_bind; pfam04205
457570002023	FMN-binding domain; Region: FMN_bind; cl01081
457570002024	FMN-binding domain; Region: FMN_bind; cl01081
457570002025	FMN-binding domain; Region: FMN_bind; cl01081
457570002026	FMN-binding domain; Region: FMN_bind; cl01081
457570002027	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
457570002028	B12 binding domain; Region: B12-binding_2; pfam02607
457570002029	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
457570002030	B12 binding site [chemical binding]; other site
457570002031	FOG: CBS domain [General function prediction only]; Region: COG0517
457570002032	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
457570002033	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
457570002034	putative active site [active]
457570002035	Zn binding site [ion binding]; other site
457570002036	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
457570002037	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
457570002038	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570002039	hypothetical protein; Provisional; Region: PHA03169
457570002040	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
457570002041	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570002042	Predicted membrane protein [Function unknown]; Region: COG2311
457570002043	Protein of unknown function (DUF418); Region: DUF418; cl12135
457570002044	Protein of unknown function (DUF418); Region: DUF418; pfam04235
457570002045	homoserine dehydrogenase; Provisional; Region: PRK06349
457570002046	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
457570002047	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
457570002048	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
457570002049	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
457570002050	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
457570002051	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
457570002052	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
457570002053	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570002054	FeS/SAM binding site; other site
457570002055	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
457570002056	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
457570002057	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
457570002058	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
457570002059	homotetramer interface [polypeptide binding]; other site
457570002060	ligand binding site [chemical binding]; other site
457570002061	catalytic site [active]
457570002062	NAD binding site [chemical binding]; other site
457570002063	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570002064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570002065	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570002066	Integrase core domain; Region: rve; pfam00665
457570002067	Integrase core domain; Region: rve_3; cl15866
457570002068	S-adenosylmethionine synthetase; Validated; Region: PRK05250
457570002069	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
457570002070	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
457570002071	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
457570002072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570002073	S-adenosylmethionine binding site [chemical binding]; other site
457570002074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570002075	S-adenosylmethionine binding site [chemical binding]; other site
457570002076	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
457570002077	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
457570002078	Substrate-binding site [chemical binding]; other site
457570002079	Substrate specificity [chemical binding]; other site
457570002080	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
457570002081	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
457570002082	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
457570002083	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
457570002084	FAD binding site [chemical binding]; other site
457570002085	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
457570002086	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
457570002087	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
457570002088	substrate binding pocket [chemical binding]; other site
457570002089	dimer interface [polypeptide binding]; other site
457570002090	inhibitor binding site; inhibition site
457570002091	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
457570002092	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
457570002093	B12 binding site [chemical binding]; other site
457570002094	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
457570002095	Hemerythrin-like domain; Region: Hr-like; cd12108
457570002096	Fe binding site [ion binding]; other site
457570002097	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
457570002098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570002099	putative substrate translocation pore; other site
457570002100	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
457570002101	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
457570002102	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
457570002103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570002104	active site
457570002105	phosphorylation site [posttranslational modification]
457570002106	intermolecular recognition site; other site
457570002107	dimerization interface [polypeptide binding]; other site
457570002108	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
457570002109	DNA binding residues [nucleotide binding]
457570002110	dimerization interface [polypeptide binding]; other site
457570002111	Histidine kinase; Region: HisKA_3; pfam07730
457570002112	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570002113	ATP binding site [chemical binding]; other site
457570002114	Mg2+ binding site [ion binding]; other site
457570002115	G-X-G motif; other site
457570002116	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
457570002117	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
457570002118	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
457570002119	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
457570002120	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570002121	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570002122	putative active site [active]
457570002123	putative NTP binding site [chemical binding]; other site
457570002124	putative nucleic acid binding site [nucleotide binding]; other site
457570002125	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570002126	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
457570002127	Na2 binding site [ion binding]; other site
457570002128	putative substrate binding site 1 [chemical binding]; other site
457570002129	Na binding site 1 [ion binding]; other site
457570002130	putative substrate binding site 2 [chemical binding]; other site
457570002131	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
457570002132	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
457570002133	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
457570002134	putative dimer interface [polypeptide binding]; other site
457570002135	[2Fe-2S] cluster binding site [ion binding]; other site
457570002136	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
457570002137	dimer interface [polypeptide binding]; other site
457570002138	[2Fe-2S] cluster binding site [ion binding]; other site
457570002139	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
457570002140	SLBB domain; Region: SLBB; pfam10531
457570002141	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
457570002142	4Fe-4S binding domain; Region: Fer4; pfam00037
457570002143	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
457570002144	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
457570002145	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
457570002146	catalytic loop [active]
457570002147	iron binding site [ion binding]; other site
457570002148	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
457570002149	4Fe-4S binding domain; Region: Fer4; pfam00037
457570002150	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
457570002151	[4Fe-4S] binding site [ion binding]; other site
457570002152	molybdopterin cofactor binding site; other site
457570002153	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
457570002154	molybdopterin cofactor binding site; other site
457570002155	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
457570002156	active site
457570002157	dimer interfaces [polypeptide binding]; other site
457570002158	catalytic residues [active]
457570002159	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
457570002160	active site
457570002161	DNA binding site [nucleotide binding]
457570002162	Predicted membrane protein [Function unknown]; Region: COG2323
457570002163	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
457570002164	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570002165	Transposase; Region: HTH_Tnp_1; pfam01527
457570002166	Serpin (serine protease inhibitor); Region: Serpin; pfam00079
457570002167	reactive center loop; other site
457570002168	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
457570002169	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
457570002170	T-box leader as predicted by Rfam (RF00230), score 67.03; T-box leader sequence
457570002171	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
457570002172	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
457570002173	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570002174	catalytic residue [active]
457570002175	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
457570002176	Beta-lactamase; Region: Beta-lactamase; pfam00144
457570002177	Beta-lactamase; Region: Beta-lactamase; cl17358
457570002178	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
457570002179	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
457570002180	NADP binding site [chemical binding]; other site
457570002181	homodimer interface [polypeptide binding]; other site
457570002182	active site
457570002183	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
457570002184	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
457570002185	putative active site [active]
457570002186	putative metal binding site [ion binding]; other site
457570002187	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
457570002188	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
457570002189	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
457570002190	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
457570002191	[2Fe-2S] cluster binding site [ion binding]; other site
457570002192	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570002193	KWG Leptospira; Region: KWG; pfam07656
457570002194	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
457570002195	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
457570002196	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
457570002197	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
457570002198	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
457570002199	Walker A/P-loop; other site
457570002200	ATP binding site [chemical binding]; other site
457570002201	Q-loop/lid; other site
457570002202	ABC transporter signature motif; other site
457570002203	Walker B; other site
457570002204	D-loop; other site
457570002205	H-loop/switch region; other site
457570002206	Predicted transcriptional regulators [Transcription]; Region: COG1725
457570002207	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
457570002208	DNA-binding site [nucleotide binding]; DNA binding site
457570002209	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
457570002210	E-class dimer interface [polypeptide binding]; other site
457570002211	P-class dimer interface [polypeptide binding]; other site
457570002212	active site
457570002213	Cu2+ binding site [ion binding]; other site
457570002214	Zn2+ binding site [ion binding]; other site
457570002215	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
457570002216	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
457570002217	Helix-turn-helix domain; Region: HTH_28; pfam13518
457570002218	Winged helix-turn helix; Region: HTH_29; pfam13551
457570002219	Integrase core domain; Region: rve; pfam00665
457570002220	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
457570002221	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
457570002222	Transglycosylase; Region: Transgly; pfam00912
457570002223	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
457570002224	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
457570002225	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
457570002226	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570002227	non-specific DNA binding site [nucleotide binding]; other site
457570002228	salt bridge; other site
457570002229	sequence-specific DNA binding site [nucleotide binding]; other site
457570002230	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
457570002231	PQQ-like domain; Region: PQQ_2; pfam13360
457570002232	TSCPD domain; Region: TSCPD; cl14834
457570002233	Trm112p-like protein; Region: Trm112p; cl01066
457570002234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570002235	S-adenosylmethionine binding site [chemical binding]; other site
457570002236	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570002237	non-specific DNA binding site [nucleotide binding]; other site
457570002238	salt bridge; other site
457570002239	sequence-specific DNA binding site [nucleotide binding]; other site
457570002240	Predicted membrane protein [Function unknown]; Region: COG2311
457570002241	Protein of unknown function (DUF418); Region: DUF418; cl12135
457570002242	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
457570002243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570002244	active site
457570002245	phosphorylation site [posttranslational modification]
457570002246	intermolecular recognition site; other site
457570002247	dimerization interface [polypeptide binding]; other site
457570002248	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
457570002249	DNA binding residues [nucleotide binding]
457570002250	dimerization interface [polypeptide binding]; other site
457570002251	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
457570002252	Histidine kinase; Region: HisKA_3; pfam07730
457570002253	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
457570002254	ATP binding site [chemical binding]; other site
457570002255	Mg2+ binding site [ion binding]; other site
457570002256	G-X-G motif; other site
457570002257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
457570002258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
457570002259	phosphoenolpyruvate synthase; Validated; Region: PRK06241
457570002260	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
457570002261	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
457570002262	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
457570002263	Predicted permease; Region: DUF318; cl17795
457570002264	Predicted permease; Region: DUF318; cl17795
457570002265	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
457570002266	dimerization interface [polypeptide binding]; other site
457570002267	putative DNA binding site [nucleotide binding]; other site
457570002268	putative Zn2+ binding site [ion binding]; other site
457570002269	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
457570002270	dimerization interface [polypeptide binding]; other site
457570002271	putative DNA binding site [nucleotide binding]; other site
457570002272	putative Zn2+ binding site [ion binding]; other site
457570002273	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
457570002274	Sodium Bile acid symporter family; Region: SBF; cl17470
457570002275	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
457570002276	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570002277	Transposase; Region: HTH_Tnp_1; pfam01527
457570002278	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570002279	Transposase; Region: HTH_Tnp_1; pfam01527
457570002280	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570002281	Transposase; Region: HTH_Tnp_1; pfam01527
457570002282	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
457570002283	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
457570002284	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
457570002285	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
457570002286	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
457570002287	catalytic loop [active]
457570002288	iron binding site [ion binding]; other site
457570002289	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
457570002290	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
457570002291	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
457570002292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
457570002293	Nucleoside recognition; Region: Gate; pfam07670
457570002294	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
457570002295	Na binding site [ion binding]; other site
457570002296	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
457570002297	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
457570002298	active site
457570002299	FMN binding site [chemical binding]; other site
457570002300	substrate binding site [chemical binding]; other site
457570002301	putative catalytic residue [active]
457570002302	FMN-binding domain; Region: FMN_bind; cl01081
457570002303	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
457570002304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
457570002305	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
457570002306	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
457570002307	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
457570002308	PAS domain; Region: PAS; smart00091
457570002309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570002310	Walker A motif; other site
457570002311	ATP binding site [chemical binding]; other site
457570002312	Walker B motif; other site
457570002313	arginine finger; other site
457570002314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
457570002315	hypothetical protein; Provisional; Region: PRK10519
457570002316	isoaspartyl dipeptidase; Provisional; Region: PRK10657
457570002317	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570002318	active site
457570002319	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
457570002320	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
457570002321	metal binding site [ion binding]; metal-binding site
457570002322	PAS domain S-box; Region: sensory_box; TIGR00229
457570002323	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570002324	putative active site [active]
457570002325	heme pocket [chemical binding]; other site
457570002326	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570002327	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570002328	metal binding site [ion binding]; metal-binding site
457570002329	active site
457570002330	I-site; other site
457570002331	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570002332	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570002333	Zn2+ binding site [ion binding]; other site
457570002334	Mg2+ binding site [ion binding]; other site
457570002335	PAS fold; Region: PAS_4; pfam08448
457570002336	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570002337	putative active site [active]
457570002338	heme pocket [chemical binding]; other site
457570002339	GAF domain; Region: GAF; pfam01590
457570002340	GAF domain; Region: GAF_2; pfam13185
457570002341	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
457570002342	metal binding site [ion binding]; metal-binding site
457570002343	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
457570002344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
457570002345	Walker A motif; other site
457570002346	ATP binding site [chemical binding]; other site
457570002347	Walker B motif; other site
457570002348	arginine finger; other site
457570002349	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
457570002350	Protein of unknown function (DUF524); Region: DUF524; pfam04411
457570002351	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
457570002352	HsdM N-terminal domain; Region: HsdM_N; pfam12161
457570002353	Methyltransferase domain; Region: Methyltransf_26; pfam13659
457570002354	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
457570002355	HsdM N-terminal domain; Region: HsdM_N; pfam12161
457570002356	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
457570002357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570002358	S-adenosylmethionine binding site [chemical binding]; other site
457570002359	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
457570002360	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
457570002361	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
457570002362	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
457570002363	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
457570002364	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
457570002365	ATP binding site [chemical binding]; other site
457570002366	putative Mg++ binding site [ion binding]; other site
457570002367	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570002368	Transposase; Region: HTH_Tnp_1; pfam01527
457570002369	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
457570002370	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
457570002371	GIY-YIG motif/motif A; other site
457570002372	putative active site [active]
457570002373	putative metal binding site [ion binding]; other site
457570002374	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
457570002375	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
457570002376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570002377	Walker A motif; other site
457570002378	ATP binding site [chemical binding]; other site
457570002379	Walker B motif; other site
457570002380	arginine finger; other site
457570002381	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
457570002382	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
457570002383	Part of AAA domain; Region: AAA_19; pfam13245
457570002384	Family description; Region: UvrD_C_2; pfam13538
457570002385	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
457570002386	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
457570002387	Catalytic site [active]
457570002388	Uncharacterized conserved protein [Function unknown]; Region: COG1479
457570002389	Protein of unknown function DUF262; Region: DUF262; pfam03235
457570002390	Protein of unknown function DUF262; Region: DUF262; pfam03235
457570002391	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
457570002392	Domain of unknown function (DUF1886); Region: DUF1886; cl01666
457570002393	Protein of unknown function (DUF328); Region: DUF328; cl01143
457570002394	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570002395	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570002396	putative active site [active]
457570002397	putative NTP binding site [chemical binding]; other site
457570002398	putative nucleic acid binding site [nucleotide binding]; other site
457570002399	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570002400	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
457570002401	Predicted transcriptional regulator [Transcription]; Region: COG2378
457570002402	WYL domain; Region: WYL; pfam13280
457570002403	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
457570002404	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
457570002405	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
457570002406	Walker A/P-loop; other site
457570002407	ATP binding site [chemical binding]; other site
457570002408	Q-loop/lid; other site
457570002409	ABC transporter signature motif; other site
457570002410	Walker B; other site
457570002411	D-loop; other site
457570002412	H-loop/switch region; other site
457570002413	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
457570002414	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
457570002415	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570002416	Walker A/P-loop; other site
457570002417	ATP binding site [chemical binding]; other site
457570002418	Q-loop/lid; other site
457570002419	ABC transporter signature motif; other site
457570002420	Walker B; other site
457570002421	D-loop; other site
457570002422	H-loop/switch region; other site
457570002423	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
457570002424	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
457570002425	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570002426	FeS/SAM binding site; other site
457570002427	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
457570002428	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
457570002429	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
457570002430	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
457570002431	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
457570002432	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
457570002433	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
457570002434	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
457570002435	DsrE/DsrF-like family; Region: DrsE; pfam02635
457570002436	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
457570002437	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
457570002438	Part of AAA domain; Region: AAA_19; pfam13245
457570002439	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
457570002440	AAA domain; Region: AAA_30; pfam13604
457570002441	AAA domain; Region: AAA_12; pfam13087
457570002442	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
457570002443	putative active site [active]
457570002444	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
457570002445	4Fe-4S binding domain; Region: Fer4; cl02805
457570002446	4Fe-4S binding domain; Region: Fer4; pfam00037
457570002447	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
457570002448	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
457570002449	dimer interface [polypeptide binding]; other site
457570002450	[2Fe-2S] cluster binding site [ion binding]; other site
457570002451	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
457570002452	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
457570002453	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
457570002454	Putative Fe-S cluster; Region: FeS; cl17515
457570002455	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
457570002456	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
457570002457	Part of AAA domain; Region: AAA_19; pfam13245
457570002458	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
457570002459	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
457570002460	MarR family; Region: MarR_2; pfam12802
457570002461	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
457570002462	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
457570002463	carboxyltransferase (CT) interaction site; other site
457570002464	biotinylation site [posttranslational modification]; other site
457570002465	biotin carboxylase; Validated; Region: PRK05586
457570002466	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
457570002467	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
457570002468	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
457570002469	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
457570002470	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
457570002471	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
457570002472	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
457570002473	Nuclease-related domain; Region: NERD; pfam08378
457570002474	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
457570002475	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
457570002476	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570002477	putative substrate translocation pore; other site
457570002478	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
457570002479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570002480	5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231
457570002481	ATP binding site [chemical binding]; other site
457570002482	active site
457570002483	substrate binding site [chemical binding]; other site
457570002484	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
457570002485	Uncharacterized conserved protein [Function unknown]; Region: COG2966
457570002486	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
457570002487	heat shock protein 90; Provisional; Region: PRK05218
457570002488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570002489	ATP binding site [chemical binding]; other site
457570002490	Mg2+ binding site [ion binding]; other site
457570002491	G-X-G motif; other site
457570002492	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
457570002493	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
457570002494	active site
457570002495	metal binding site [ion binding]; metal-binding site
457570002496	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
457570002497	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
457570002498	ACS interaction site; other site
457570002499	CODH interaction site; other site
457570002500	cubane metal cluster (B-cluster) [ion binding]; other site
457570002501	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
457570002502	flavoprotein, HI0933 family; Region: TIGR00275
457570002503	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
457570002504	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
457570002505	Na binding site [ion binding]; other site
457570002506	Protein of unknown function (DUF917); Region: DUF917; pfam06032
457570002507	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
457570002508	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
457570002509	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
457570002510	Predicted permeases [General function prediction only]; Region: RarD; COG2962
457570002511	EamA-like transporter family; Region: EamA; cl17759
457570002512	Protein of unknown function, DUF606; Region: DUF606; pfam04657
457570002513	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
457570002514	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
457570002515	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
457570002516	Ca binding site [ion binding]; other site
457570002517	active site
457570002518	catalytic site [active]
457570002519	Predicted permease [General function prediction only]; Region: COG2985
457570002520	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
457570002521	TrkA-C domain; Region: TrkA_C; pfam02080
457570002522	TrkA-C domain; Region: TrkA_C; pfam02080
457570002523	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
457570002524	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
457570002525	Uncharacterized conserved protein [Function unknown]; Region: COG0398
457570002526	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
457570002527	Spore germination protein; Region: Spore_permease; cl17796
457570002528	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
457570002529	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
457570002530	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
457570002531	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
457570002532	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
457570002533	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
457570002534	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
457570002535	hypothetical protein; Provisional; Region: PRK02399
457570002536	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
457570002537	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
457570002538	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
457570002539	4Fe-4S binding domain; Region: Fer4; pfam00037
457570002540	4Fe-4S binding domain; Region: Fer4; pfam00037
457570002541	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
457570002542	Bacterial SH3 domain; Region: SH3_3; pfam08239
457570002543	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
457570002544	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
457570002545	active site
457570002546	metal binding site [ion binding]; metal-binding site
457570002547	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849
457570002548	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
457570002549	Transposase, Mutator family; Region: Transposase_mut; pfam00872
457570002550	MULE transposase domain; Region: MULE; pfam10551
457570002551	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
457570002552	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
457570002553	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
457570002554	TrkA-N domain; Region: TrkA_N; pfam02254
457570002555	TrkA-C domain; Region: TrkA_C; pfam02080
457570002556	TrkA-N domain; Region: TrkA_N; pfam02254
457570002557	TrkA-C domain; Region: TrkA_C; pfam02080
457570002558	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
457570002559	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
457570002560	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
457570002561	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
457570002562	putative NAD(P) binding site [chemical binding]; other site
457570002563	catalytic Zn binding site [ion binding]; other site
457570002564	structural Zn binding site [ion binding]; other site
457570002565	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
457570002566	Part of AAA domain; Region: AAA_19; pfam13245
457570002567	Family description; Region: UvrD_C_2; pfam13538
457570002568	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
457570002569	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
457570002570	active site
457570002571	metal binding site [ion binding]; metal-binding site
457570002572	P-loop containing region of AAA domain; Region: AAA_29; cl17516
457570002573	LXG domain of WXG superfamily; Region: LXG; pfam04740
457570002574	Ion channel; Region: Ion_trans_2; pfam07885
457570002575	TrkA-N domain; Region: TrkA_N; pfam02254
457570002576	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570002577	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
457570002578	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
457570002579	N-acetyl-D-glucosamine binding site [chemical binding]; other site
457570002580	catalytic residue [active]
457570002581	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
457570002582	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
457570002583	ATP binding site [chemical binding]; other site
457570002584	Mg++ binding site [ion binding]; other site
457570002585	motif III; other site
457570002586	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
457570002587	nucleotide binding region [chemical binding]; other site
457570002588	ATP-binding site [chemical binding]; other site
457570002589	EDD domain protein, DegV family; Region: DegV; TIGR00762
457570002590	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
457570002591	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
457570002592	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570002593	FeS/SAM binding site; other site
457570002594	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
457570002595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
457570002596	ABC-2 type transporter; Region: ABC2_membrane; cl17235
457570002597	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
457570002598	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
457570002599	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570002600	Walker A/P-loop; other site
457570002601	ATP binding site [chemical binding]; other site
457570002602	Q-loop/lid; other site
457570002603	ABC transporter signature motif; other site
457570002604	Walker B; other site
457570002605	D-loop; other site
457570002606	H-loop/switch region; other site
457570002607	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
457570002608	Uncharacterized conserved protein [Function unknown]; Region: COG1615
457570002609	threonine synthase; Reviewed; Region: PRK06721
457570002610	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
457570002611	homodimer interface [polypeptide binding]; other site
457570002612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570002613	catalytic residue [active]
457570002614	homoserine kinase; Provisional; Region: PRK01212
457570002615	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
457570002616	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
457570002617	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
457570002618	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
457570002619	putative active site [active]
457570002620	catalytic site [active]
457570002621	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
457570002622	putative active site [active]
457570002623	catalytic site [active]
457570002624	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
457570002625	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
457570002626	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570002627	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
457570002628	4Fe-4S binding domain; Region: Fer4_5; pfam12801
457570002629	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570002630	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
457570002631	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
457570002632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570002633	active site
457570002634	phosphorylation site [posttranslational modification]
457570002635	intermolecular recognition site; other site
457570002636	dimerization interface [polypeptide binding]; other site
457570002637	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
457570002638	DNA binding site [nucleotide binding]
457570002639	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
457570002640	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
457570002641	dimerization interface [polypeptide binding]; other site
457570002642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
457570002643	dimer interface [polypeptide binding]; other site
457570002644	phosphorylation site [posttranslational modification]
457570002645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570002646	ATP binding site [chemical binding]; other site
457570002647	Mg2+ binding site [ion binding]; other site
457570002648	G-X-G motif; other site
457570002649	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570002650	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
457570002651	argininosuccinate lyase; Provisional; Region: PRK00855
457570002652	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
457570002653	active sites [active]
457570002654	tetramer interface [polypeptide binding]; other site
457570002655	argininosuccinate synthase; Provisional; Region: PRK13820
457570002656	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
457570002657	ANP binding site [chemical binding]; other site
457570002658	Substrate Binding Site II [chemical binding]; other site
457570002659	Substrate Binding Site I [chemical binding]; other site
457570002660	T-box leader as predicted by Rfam (RF00230), score 91.24; T-box leader sequence
457570002661	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
457570002662	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
457570002663	Helix-hairpin-helix motif; Region: HHH; pfam00633
457570002664	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
457570002665	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
457570002666	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
457570002667	catalytic triad [active]
457570002668	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
457570002669	Precorrin-8X methylmutase; Region: CbiC; pfam02570
457570002670	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
457570002671	putative active site [active]
457570002672	Uncharacterized conserved protein [Function unknown]; Region: COG0398
457570002673	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
457570002674	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
457570002675	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
457570002676	active site
457570002677	putative homodimer interface [polypeptide binding]; other site
457570002678	SAM binding site [chemical binding]; other site
457570002679	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
457570002680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570002681	S-adenosylmethionine binding site [chemical binding]; other site
457570002682	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
457570002683	active site
457570002684	SAM binding site [chemical binding]; other site
457570002685	homodimer interface [polypeptide binding]; other site
457570002686	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
457570002687	active site
457570002688	SAM binding site [chemical binding]; other site
457570002689	homodimer interface [polypeptide binding]; other site
457570002690	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
457570002691	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
457570002692	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
457570002693	active site
457570002694	SAM binding site [chemical binding]; other site
457570002695	homodimer interface [polypeptide binding]; other site
457570002696	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
457570002697	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
457570002698	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
457570002699	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
457570002700	homotrimer interface [polypeptide binding]; other site
457570002701	Walker A motif; other site
457570002702	GTP binding site [chemical binding]; other site
457570002703	Walker B motif; other site
457570002704	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
457570002705	cobalamin synthase; Reviewed; Region: cobS; PRK00235
457570002706	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
457570002707	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
457570002708	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
457570002709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570002710	homodimer interface [polypeptide binding]; other site
457570002711	catalytic residue [active]
457570002712	cobyric acid synthase; Provisional; Region: PRK00784
457570002713	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
457570002714	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
457570002715	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
457570002716	catalytic triad [active]
457570002717	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
457570002718	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
457570002719	motif II; other site
457570002720	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
457570002721	active site
457570002722	FOG: CBS domain [General function prediction only]; Region: COG0517
457570002723	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
457570002724	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
457570002725	active site
457570002726	putative catalytic site [active]
457570002727	DNA binding site [nucleotide binding]
457570002728	putative phosphate binding site [ion binding]; other site
457570002729	metal binding site A [ion binding]; metal-binding site
457570002730	AP binding site [nucleotide binding]; other site
457570002731	metal binding site B [ion binding]; metal-binding site
457570002732	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
457570002733	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
457570002734	NodB motif; other site
457570002735	active site
457570002736	catalytic site [active]
457570002737	Zn binding site [ion binding]; other site
457570002738	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
457570002739	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
457570002740	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
457570002741	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
457570002742	Protein of unknown function (DUF456); Region: DUF456; pfam04306
457570002743	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
457570002744	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
457570002745	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570002746	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
457570002747	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
457570002748	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
457570002749	catalytic residues [active]
457570002750	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
457570002751	active site
457570002752	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
457570002753	dimer interface [polypeptide binding]; other site
457570002754	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
457570002755	Ligand Binding Site [chemical binding]; other site
457570002756	Molecular Tunnel; other site
457570002757	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
457570002758	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
457570002759	active site
457570002760	dimer interface [polypeptide binding]; other site
457570002761	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
457570002762	Ligand Binding Site [chemical binding]; other site
457570002763	Molecular Tunnel; other site
457570002764	glutamine synthetase, type I; Region: GlnA; TIGR00653
457570002765	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
457570002766	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
457570002767	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
457570002768	ANTAR domain; Region: ANTAR; pfam03861
457570002769	Predicted transcriptional regulators [Transcription]; Region: COG1695
457570002770	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
457570002771	Predicted permeases [General function prediction only]; Region: COG0701
457570002772	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
457570002773	Uncharacterized conserved protein [Function unknown]; Region: COG1615
457570002774	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
457570002775	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
457570002776	active site
457570002777	FMN binding site [chemical binding]; other site
457570002778	substrate binding site [chemical binding]; other site
457570002779	putative catalytic residue [active]
457570002780	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
457570002781	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570002782	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
457570002783	Low molecular weight phosphatase family; Region: LMWPc; cd00115
457570002784	active site
457570002785	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570002786	Radical SAM superfamily; Region: Radical_SAM; pfam04055
457570002787	FeS/SAM binding site; other site
457570002788	Uncharacterized conserved protein [Function unknown]; Region: COG3342
457570002789	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
457570002790	Cupin domain; Region: Cupin_2; cl17218
457570002791	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
457570002792	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570002793	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570002794	putative active site [active]
457570002795	putative NTP binding site [chemical binding]; other site
457570002796	putative nucleic acid binding site [nucleotide binding]; other site
457570002797	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570002798	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570002799	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570002800	putative active site [active]
457570002801	putative NTP binding site [chemical binding]; other site
457570002802	putative nucleic acid binding site [nucleotide binding]; other site
457570002803	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570002804	hybrid cluster protein; Provisional; Region: PRK05290
457570002805	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570002806	ACS interaction site; other site
457570002807	CODH interaction site; other site
457570002808	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
457570002809	hybrid metal cluster; other site
457570002810	FMN-binding domain; Region: FMN_bind; cl01081
457570002811	PBP superfamily domain; Region: PBP_like_2; cl17296
457570002812	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
457570002813	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570002814	dimer interface [polypeptide binding]; other site
457570002815	conserved gate region; other site
457570002816	putative PBP binding loops; other site
457570002817	ABC-ATPase subunit interface; other site
457570002818	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
457570002819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570002820	dimer interface [polypeptide binding]; other site
457570002821	conserved gate region; other site
457570002822	ABC-ATPase subunit interface; other site
457570002823	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
457570002824	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
457570002825	Walker A/P-loop; other site
457570002826	ATP binding site [chemical binding]; other site
457570002827	Q-loop/lid; other site
457570002828	ABC transporter signature motif; other site
457570002829	Walker B; other site
457570002830	D-loop; other site
457570002831	H-loop/switch region; other site
457570002832	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
457570002833	PhoU domain; Region: PhoU; pfam01895
457570002834	PhoU domain; Region: PhoU; pfam01895
457570002835	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
457570002836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570002837	active site
457570002838	phosphorylation site [posttranslational modification]
457570002839	intermolecular recognition site; other site
457570002840	dimerization interface [polypeptide binding]; other site
457570002841	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
457570002842	DNA binding site [nucleotide binding]
457570002843	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
457570002844	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
457570002845	dimerization interface [polypeptide binding]; other site
457570002846	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
457570002847	PAS domain; Region: PAS; smart00091
457570002848	putative active site [active]
457570002849	heme pocket [chemical binding]; other site
457570002850	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
457570002851	dimer interface [polypeptide binding]; other site
457570002852	phosphorylation site [posttranslational modification]
457570002853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570002854	ATP binding site [chemical binding]; other site
457570002855	Mg2+ binding site [ion binding]; other site
457570002856	G-X-G motif; other site
457570002857	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
457570002858	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
457570002859	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
457570002860	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570002861	Walker A/P-loop; other site
457570002862	ATP binding site [chemical binding]; other site
457570002863	Q-loop/lid; other site
457570002864	ABC transporter signature motif; other site
457570002865	Walker B; other site
457570002866	D-loop; other site
457570002867	H-loop/switch region; other site
457570002868	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
457570002869	dimerization interface [polypeptide binding]; other site
457570002870	putative DNA binding site [nucleotide binding]; other site
457570002871	putative Zn2+ binding site [ion binding]; other site
457570002872	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
457570002873	Carbon starvation protein CstA; Region: CstA; pfam02554
457570002874	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
457570002875	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
457570002876	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
457570002877	FAD binding domain; Region: FAD_binding_4; pfam01565
457570002878	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
457570002879	hypothetical protein; Provisional; Region: PRK06446
457570002880	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
457570002881	metal binding site [ion binding]; metal-binding site
457570002882	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
457570002883	Histone deacetylase domain; Region: Hist_deacetyl; pfam00850
457570002884	active site
457570002885	metal binding site [ion binding]; metal-binding site
457570002886	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
457570002887	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
457570002888	G1 box; other site
457570002889	putative GEF interaction site [polypeptide binding]; other site
457570002890	GTP/Mg2+ binding site [chemical binding]; other site
457570002891	Switch I region; other site
457570002892	G2 box; other site
457570002893	G3 box; other site
457570002894	Switch II region; other site
457570002895	G4 box; other site
457570002896	G5 box; other site
457570002897	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
457570002898	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
457570002899	Predicted transcriptional regulators [Transcription]; Region: COG1725
457570002900	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
457570002901	DNA-binding site [nucleotide binding]; DNA binding site
457570002902	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
457570002903	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
457570002904	Walker A/P-loop; other site
457570002905	ATP binding site [chemical binding]; other site
457570002906	Q-loop/lid; other site
457570002907	ABC transporter signature motif; other site
457570002908	Walker B; other site
457570002909	D-loop; other site
457570002910	H-loop/switch region; other site
457570002911	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
457570002912	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
457570002913	PspC domain; Region: PspC; pfam04024
457570002914	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
457570002915	Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393
457570002916	putative active site [active]
457570002917	putative metal binding site [ion binding]; other site
457570002918	BCCT family transporter; Region: BCCT; pfam02028
457570002919	isoaspartyl dipeptidase; Provisional; Region: PRK10657
457570002920	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570002921	active site
457570002922	hypothetical protein; Provisional; Region: PRK11588
457570002923	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
457570002924	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570002925	putative active site [active]
457570002926	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
457570002927	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570002928	Walker A motif; other site
457570002929	ATP binding site [chemical binding]; other site
457570002930	Walker B motif; other site
457570002931	arginine finger; other site
457570002932	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
457570002933	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
457570002934	catalytic core [active]
457570002935	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
457570002936	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570002937	dimer interface [polypeptide binding]; other site
457570002938	putative CheW interface [polypeptide binding]; other site
457570002939	LrgA family; Region: LrgA; pfam03788
457570002940	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
457570002941	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570002942	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
457570002943	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570002944	Walker A/P-loop; other site
457570002945	ATP binding site [chemical binding]; other site
457570002946	Q-loop/lid; other site
457570002947	ABC transporter signature motif; other site
457570002948	Walker B; other site
457570002949	D-loop; other site
457570002950	H-loop/switch region; other site
457570002951	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
457570002952	Beta-lactamase; Region: Beta-lactamase; pfam00144
457570002953	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
457570002954	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
457570002955	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
457570002956	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
457570002957	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
457570002958	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
457570002959	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
457570002960	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
457570002961	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
457570002962	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
457570002963	active site
457570002964	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570002965	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
457570002966	Transposase IS200 like; Region: Y1_Tnp; pfam01797
457570002967	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
457570002968	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
457570002969	active site
457570002970	FMN binding site [chemical binding]; other site
457570002971	substrate binding site [chemical binding]; other site
457570002972	putative catalytic residue [active]
457570002973	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570002974	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570002975	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
457570002976	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
457570002977	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
457570002978	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570002979	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570002980	DNA binding residues [nucleotide binding]
457570002981	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
457570002982	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
457570002983	active site
457570002984	DNA binding site [nucleotide binding]
457570002985	Int/Topo IB signature motif; other site
457570002986	HEPN domain; Region: HEPN; pfam05168
457570002987	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
457570002988	active site
457570002989	NTP binding site [chemical binding]; other site
457570002990	metal binding triad [ion binding]; metal-binding site
457570002991	antibiotic binding site [chemical binding]; other site
457570002992	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
457570002993	catalytic motif [active]
457570002994	Catalytic residue [active]
457570002995	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570002996	non-specific DNA binding site [nucleotide binding]; other site
457570002997	salt bridge; other site
457570002998	sequence-specific DNA binding site [nucleotide binding]; other site
457570002999	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
457570003000	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570003001	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570003002	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570003003	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
457570003004	active site
457570003005	NTP binding site [chemical binding]; other site
457570003006	metal binding triad [ion binding]; metal-binding site
457570003007	antibiotic binding site [chemical binding]; other site
457570003008	Uncharacterized conserved protein [Function unknown]; Region: COG2361
457570003009	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
457570003010	inhibitor binding site; inhibition site
457570003011	catalytic motif [active]
457570003012	Catalytic residue [active]
457570003013	Active site flap [active]
457570003014	Methyltransferase domain; Region: Methyltransf_31; pfam13847
457570003015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570003016	S-adenosylmethionine binding site [chemical binding]; other site
457570003017	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
457570003018	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570003019	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570003020	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
457570003021	Leucine rich repeat; Region: LRR_8; pfam13855
457570003022	CAAX protease self-immunity; Region: Abi; pfam02517
457570003023	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570003024	S-adenosylmethionine binding site [chemical binding]; other site
457570003025	TraB family; Region: TraB; pfam01963
457570003026	TraB family; Region: TraB; cl12050
457570003027	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
457570003028	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
457570003029	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
457570003030	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
457570003031	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
457570003032	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
457570003033	putative active site [active]
457570003034	putative metal binding residues [ion binding]; other site
457570003035	signature motif; other site
457570003036	putative triphosphate binding site [ion binding]; other site
457570003037	dimer interface [polypeptide binding]; other site
457570003038	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570003039	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570003040	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
457570003041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
457570003042	Coenzyme A binding pocket [chemical binding]; other site
457570003043	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
457570003044	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
457570003045	active site
457570003046	catalytic tetrad [active]
457570003047	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570003048	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570003049	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570003050	Integrase core domain; Region: rve; pfam00665
457570003051	Integrase core domain; Region: rve_3; cl15866
457570003052	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
457570003053	active site
457570003054	NTP binding site [chemical binding]; other site
457570003055	metal binding triad [ion binding]; metal-binding site
457570003056	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
457570003057	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
457570003058	active site
457570003059	threonine synthase; Validated; Region: PRK05638
457570003060	Predicted amidohydrolase [General function prediction only]; Region: COG0388
457570003061	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
457570003062	putative active site [active]
457570003063	catalytic triad [active]
457570003064	putative dimer interface [polypeptide binding]; other site
457570003065	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
457570003066	GIY-YIG motif/motif A; other site
457570003067	putative active site [active]
457570003068	putative metal binding site [ion binding]; other site
457570003069	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
457570003070	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
457570003071	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
457570003072	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
457570003073	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
457570003074	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570003075	Bacterial SH3 domain; Region: SH3_3; pfam08239
457570003076	Bacterial SH3 domain; Region: SH3_3; pfam08239
457570003077	AMIN domain; Region: AMIN; pfam11741
457570003078	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
457570003079	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
457570003080	active site
457570003081	metal binding site [ion binding]; metal-binding site
457570003082	Transposase, Mutator family; Region: Transposase_mut; pfam00872
457570003083	MULE transposase domain; Region: MULE; pfam10551
457570003084	FMN-binding domain; Region: FMN_bind; cl01081
457570003085	FMN-binding domain; Region: FMN_bind; pfam04205
457570003086	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
457570003087	SLBB domain; Region: SLBB; pfam10531
457570003088	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
457570003089	FMN-binding domain; Region: FMN_bind; cl01081
457570003090	FMN-binding domain; Region: FMN_bind; cl01081
457570003091	FMN-binding domain; Region: FMN_bind; cl01081
457570003092	electron transport complex RsxE subunit; Provisional; Region: PRK12405
457570003093	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
457570003094	ferredoxin; Validated; Region: PRK07118
457570003095	Putative Fe-S cluster; Region: FeS; cl17515
457570003096	Domain of unknown function (DUF3787); Region: DUF3787; pfam12655
457570003097	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
457570003098	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
457570003099	dimer interface [polypeptide binding]; other site
457570003100	PYR/PP interface [polypeptide binding]; other site
457570003101	TPP binding site [chemical binding]; other site
457570003102	substrate binding site [chemical binding]; other site
457570003103	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
457570003104	Domain of unknown function; Region: EKR; smart00890
457570003105	4Fe-4S binding domain; Region: Fer4_6; pfam12837
457570003106	4Fe-4S binding domain; Region: Fer4; pfam00037
457570003107	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
457570003108	TPP-binding site [chemical binding]; other site
457570003109	dimer interface [polypeptide binding]; other site
457570003110	uracil-xanthine permease; Region: ncs2; TIGR00801
457570003111	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
457570003112	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
457570003113	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
457570003114	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
457570003115	dimer interface [polypeptide binding]; other site
457570003116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570003117	catalytic residue [active]
457570003118	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
457570003119	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
457570003120	ATP binding site [chemical binding]; other site
457570003121	substrate interface [chemical binding]; other site
457570003122	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
457570003123	MPN+ (JAMM) motif; other site
457570003124	Zinc-binding site [ion binding]; other site
457570003125	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
457570003126	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
457570003127	HEPN domain; Region: HEPN; cl00824
457570003128	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
457570003129	CPxP  motif; other site
457570003130	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
457570003131	thiS-thiF/thiG interaction site; other site
457570003132	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
457570003133	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
457570003134	metal-binding site [ion binding]
457570003135	Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611
457570003136	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
457570003137	dimerization interface [polypeptide binding]; other site
457570003138	ATP binding site [chemical binding]; other site
457570003139	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
457570003140	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
457570003141	homotetramer interface [polypeptide binding]; other site
457570003142	ligand binding site [chemical binding]; other site
457570003143	catalytic site [active]
457570003144	NAD binding site [chemical binding]; other site
457570003145	trigger factor; Provisional; Region: tig; PRK01490
457570003146	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
457570003147	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
457570003148	Clp protease; Region: CLP_protease; pfam00574
457570003149	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
457570003150	oligomer interface [polypeptide binding]; other site
457570003151	active site residues [active]
457570003152	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
457570003153	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
457570003154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570003155	Walker A motif; other site
457570003156	ATP binding site [chemical binding]; other site
457570003157	Walker B motif; other site
457570003158	arginine finger; other site
457570003159	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
457570003160	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
457570003161	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570003162	Walker A motif; other site
457570003163	ATP binding site [chemical binding]; other site
457570003164	Walker B motif; other site
457570003165	arginine finger; other site
457570003166	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
457570003167	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
457570003168	G1 box; other site
457570003169	GTP/Mg2+ binding site [chemical binding]; other site
457570003170	Switch I region; other site
457570003171	G2 box; other site
457570003172	G3 box; other site
457570003173	Switch II region; other site
457570003174	G4 box; other site
457570003175	G5 box; other site
457570003176	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
457570003177	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
457570003178	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
457570003179	nucleotide binding region [chemical binding]; other site
457570003180	Rubrerythrin [Energy production and conversion]; Region: COG1592
457570003181	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
457570003182	diiron binding motif [ion binding]; other site
457570003183	T-box leader as predicted by Rfam (RF00230), score 98.79; T-box leader sequence
457570003184	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
457570003185	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
457570003186	HIGH motif; other site
457570003187	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
457570003188	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
457570003189	active site
457570003190	KMSKS motif; other site
457570003191	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
457570003192	tRNA binding surface [nucleotide binding]; other site
457570003193	anticodon binding site; other site
457570003194	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
457570003195	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
457570003196	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
457570003197	active site
457570003198	catalytic residues [active]
457570003199	DNA binding site [nucleotide binding]
457570003200	Int/Topo IB signature motif; other site
457570003201	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570003202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570003203	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570003204	SLBB domain; Region: SLBB; pfam10531
457570003205	Helix-hairpin-helix motif; Region: HHH; pfam00633
457570003206	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
457570003207	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
457570003208	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
457570003209	G1 box; other site
457570003210	putative GEF interaction site [polypeptide binding]; other site
457570003211	GTP/Mg2+ binding site [chemical binding]; other site
457570003212	Switch I region; other site
457570003213	G2 box; other site
457570003214	G3 box; other site
457570003215	Switch II region; other site
457570003216	G4 box; other site
457570003217	G5 box; other site
457570003218	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
457570003219	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
457570003220	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
457570003221	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
457570003222	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
457570003223	dimerization interface [polypeptide binding]; other site
457570003224	putative ATP binding site [chemical binding]; other site
457570003225	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
457570003226	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
457570003227	active site
457570003228	catalytic site [active]
457570003229	metal binding site [ion binding]; metal-binding site
457570003230	dimer interface [polypeptide binding]; other site
457570003231	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
457570003232	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
457570003233	metal binding site [ion binding]; metal-binding site
457570003234	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
457570003235	ResB-like family; Region: ResB; pfam05140
457570003236	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
457570003237	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
457570003238	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
457570003239	tRNA; other site
457570003240	putative tRNA binding site [nucleotide binding]; other site
457570003241	putative NADP binding site [chemical binding]; other site
457570003242	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
457570003243	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
457570003244	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
457570003245	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
457570003246	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
457570003247	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
457570003248	domain interfaces; other site
457570003249	active site
457570003250	Predicted methyltransferases [General function prediction only]; Region: COG0313
457570003251	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
457570003252	active site
457570003253	SAM binding site [chemical binding]; other site
457570003254	homodimer interface [polypeptide binding]; other site
457570003255	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
457570003256	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
457570003257	active site
457570003258	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
457570003259	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570003260	FeS/SAM binding site; other site
457570003261	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
457570003262	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
457570003263	dimer interface [polypeptide binding]; other site
457570003264	active site
457570003265	Schiff base residues; other site
457570003266	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
457570003267	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570003268	FeS/SAM binding site; other site
457570003269	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
457570003270	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
457570003271	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
457570003272	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
457570003273	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
457570003274	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
457570003275	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
457570003276	inhibitor-cofactor binding pocket; inhibition site
457570003277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570003278	catalytic residue [active]
457570003279	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
457570003280	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
457570003281	active site
457570003282	substrate binding site [chemical binding]; other site
457570003283	metal binding site [ion binding]; metal-binding site
457570003284	metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921
457570003285	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
457570003286	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
457570003287	Predicted membrane protein [Function unknown]; Region: COG2119
457570003288	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
457570003289	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
457570003290	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
457570003291	metal binding site 2 [ion binding]; metal-binding site
457570003292	putative DNA binding helix; other site
457570003293	metal binding site 1 [ion binding]; metal-binding site
457570003294	dimer interface [polypeptide binding]; other site
457570003295	structural Zn2+ binding site [ion binding]; other site
457570003296	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
457570003297	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
457570003298	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570003299	Walker A/P-loop; other site
457570003300	ATP binding site [chemical binding]; other site
457570003301	Q-loop/lid; other site
457570003302	ABC transporter signature motif; other site
457570003303	Walker B; other site
457570003304	D-loop; other site
457570003305	H-loop/switch region; other site
457570003306	Predicted transcriptional regulators [Transcription]; Region: COG1695
457570003307	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
457570003308	hypothetical protein; Provisional; Region: PRK05463
457570003309	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
457570003310	putative active site [active]
457570003311	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
457570003312	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
457570003313	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
457570003314	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
457570003315	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
457570003316	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
457570003317	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
457570003318	active site
457570003319	tetramer interface [polypeptide binding]; other site
457570003320	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
457570003321	active site
457570003322	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
457570003323	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
457570003324	active site
457570003325	putative substrate binding pocket [chemical binding]; other site
457570003326	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
457570003327	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
457570003328	inhibitor-cofactor binding pocket; inhibition site
457570003329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570003330	catalytic residue [active]
457570003331	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
457570003332	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570003333	FeS/SAM binding site; other site
457570003334	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
457570003335	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
457570003336	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
457570003337	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
457570003338	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
457570003339	PA/protease or protease-like domain interface [polypeptide binding]; other site
457570003340	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
457570003341	Peptidase family M28; Region: Peptidase_M28; pfam04389
457570003342	metal binding site [ion binding]; metal-binding site
457570003343	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
457570003344	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
457570003345	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
457570003346	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
457570003347	FMN binding site [chemical binding]; other site
457570003348	substrate binding site [chemical binding]; other site
457570003349	putative catalytic residue [active]
457570003350	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
457570003351	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
457570003352	metal binding site [ion binding]; metal-binding site
457570003353	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
457570003354	active site
457570003355	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
457570003356	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
457570003357	homodimer interface [polypeptide binding]; other site
457570003358	substrate-cofactor binding pocket; other site
457570003359	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570003360	catalytic residue [active]
457570003361	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
457570003362	Transcriptional regulator [Transcription]; Region: IclR; COG1414
457570003363	Bacterial transcriptional regulator; Region: IclR; pfam01614
457570003364	selenocysteine synthase; Provisional; Region: PRK04311
457570003365	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
457570003366	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
457570003367	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
457570003368	catalytic residue [active]
457570003369	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
457570003370	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
457570003371	UbiA prenyltransferase family; Region: UbiA; pfam01040
457570003372	PAS domain; Region: PAS; smart00091
457570003373	PAS fold; Region: PAS_4; pfam08448
457570003374	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
457570003375	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570003376	Walker A motif; other site
457570003377	ATP binding site [chemical binding]; other site
457570003378	Walker B motif; other site
457570003379	arginine finger; other site
457570003380	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
457570003381	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
457570003382	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
457570003383	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
457570003384	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
457570003385	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
457570003386	catalytic residue [active]
457570003387	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
457570003388	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
457570003389	B12 binding site [chemical binding]; other site
457570003390	MutL protein; Region: MutL; pfam13941
457570003391	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
457570003392	RNA/DNA hybrid binding site [nucleotide binding]; other site
457570003393	active site
457570003394	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
457570003395	Competence protein; Region: Competence; pfam03772
457570003396	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
457570003397	Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638
457570003398	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
457570003399	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
457570003400	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
457570003401	germination protease; Provisional; Region: PRK12362
457570003402	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
457570003403	stage II sporulation protein P; Region: spore_II_P; TIGR02867
457570003404	GTP-binding protein LepA; Provisional; Region: PRK05433
457570003405	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
457570003406	G1 box; other site
457570003407	putative GEF interaction site [polypeptide binding]; other site
457570003408	GTP/Mg2+ binding site [chemical binding]; other site
457570003409	Switch I region; other site
457570003410	G2 box; other site
457570003411	G3 box; other site
457570003412	Switch II region; other site
457570003413	G4 box; other site
457570003414	G5 box; other site
457570003415	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
457570003416	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
457570003417	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
457570003418	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
457570003419	HemN C-terminal domain; Region: HemN_C; pfam06969
457570003420	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
457570003421	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
457570003422	GrpE; Region: GrpE; pfam01025
457570003423	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
457570003424	dimer interface [polypeptide binding]; other site
457570003425	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
457570003426	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
457570003427	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
457570003428	nucleotide binding site [chemical binding]; other site
457570003429	NEF interaction site [polypeptide binding]; other site
457570003430	SBD interface [polypeptide binding]; other site
457570003431	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
457570003432	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
457570003433	HSP70 interaction site [polypeptide binding]; other site
457570003434	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
457570003435	substrate binding site [polypeptide binding]; other site
457570003436	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
457570003437	Zn binding sites [ion binding]; other site
457570003438	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
457570003439	dimer interface [polypeptide binding]; other site
457570003440	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
457570003441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570003442	S-adenosylmethionine binding site [chemical binding]; other site
457570003443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
457570003444	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
457570003445	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
457570003446	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570003447	FeS/SAM binding site; other site
457570003448	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
457570003449	nucleotide binding site/active site [active]
457570003450	HIT family signature motif; other site
457570003451	catalytic residue [active]
457570003452	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
457570003453	Yqey-like protein; Region: YqeY; pfam09424
457570003454	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
457570003455	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
457570003456	dimer interface [polypeptide binding]; other site
457570003457	active site residues [active]
457570003458	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
457570003459	hypothetical protein; Provisional; Region: PRK13665
457570003460	YabP family; Region: YabP; cl06766
457570003461	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
457570003462	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
457570003463	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
457570003464	PhoH-like protein; Region: PhoH; pfam02562
457570003465	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
457570003466	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
457570003467	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570003468	Zn2+ binding site [ion binding]; other site
457570003469	Mg2+ binding site [ion binding]; other site
457570003470	metal-binding heat shock protein; Provisional; Region: PRK00016
457570003471	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
457570003472	Uncharacterized conserved protein [Function unknown]; Region: COG2928
457570003473	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
457570003474	active site
457570003475	catalytic motif [active]
457570003476	Zn binding site [ion binding]; other site
457570003477	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
457570003478	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
457570003479	active site
457570003480	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
457570003481	dimer interface [polypeptide binding]; other site
457570003482	substrate binding site [chemical binding]; other site
457570003483	catalytic residue [active]
457570003484	GTPase Era; Reviewed; Region: era; PRK00089
457570003485	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
457570003486	G1 box; other site
457570003487	GTP/Mg2+ binding site [chemical binding]; other site
457570003488	Switch I region; other site
457570003489	G2 box; other site
457570003490	Switch II region; other site
457570003491	G3 box; other site
457570003492	G4 box; other site
457570003493	G5 box; other site
457570003494	KH domain; Region: KH_2; pfam07650
457570003495	Recombination protein O N terminal; Region: RecO_N; pfam11967
457570003496	DNA repair protein RecO; Region: reco; TIGR00613
457570003497	Recombination protein O C terminal; Region: RecO_C; pfam02565
457570003498	T-box leader as predicted by Rfam (RF00230), score 77.22; T-box leader sequence
457570003499	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
457570003500	dimer interface [polypeptide binding]; other site
457570003501	motif 1; other site
457570003502	active site
457570003503	motif 2; other site
457570003504	motif 3; other site
457570003505	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
457570003506	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
457570003507	HTH domain; Region: HTH_11; pfam08279
457570003508	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
457570003509	FOG: CBS domain [General function prediction only]; Region: COG0517
457570003510	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
457570003511	pyruvate phosphate dikinase; Provisional; Region: PRK09279
457570003512	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
457570003513	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
457570003514	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
457570003515	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
457570003516	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
457570003517	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
457570003518	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
457570003519	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570003520	Zn2+ binding site [ion binding]; other site
457570003521	Mg2+ binding site [ion binding]; other site
457570003522	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
457570003523	DNA primase; Validated; Region: dnaG; PRK05667
457570003524	CHC2 zinc finger; Region: zf-CHC2; pfam01807
457570003525	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
457570003526	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
457570003527	active site
457570003528	metal binding site [ion binding]; metal-binding site
457570003529	interdomain interaction site; other site
457570003530	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
457570003531	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
457570003532	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
457570003533	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
457570003534	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
457570003535	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570003536	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
457570003537	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570003538	DNA binding residues [nucleotide binding]
457570003539	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
457570003540	Family of unknown function (DUF633); Region: DUF633; pfam04816
457570003541	Uncharacterized conserved protein [Function unknown]; Region: COG0327
457570003542	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
457570003543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
457570003544	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
457570003545	Uncharacterized conserved protein [Function unknown]; Region: COG0327
457570003546	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
457570003547	Putative zinc ribbon domain; Region: DUF164; pfam02591
457570003548	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
457570003549	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
457570003550	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
457570003551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570003552	active site
457570003553	phosphorylation site [posttranslational modification]
457570003554	intermolecular recognition site; other site
457570003555	dimerization interface [polypeptide binding]; other site
457570003556	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
457570003557	DNA binding site [nucleotide binding]
457570003558	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
457570003559	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
457570003560	dimerization interface [polypeptide binding]; other site
457570003561	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
457570003562	dimer interface [polypeptide binding]; other site
457570003563	phosphorylation site [posttranslational modification]
457570003564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570003565	ATP binding site [chemical binding]; other site
457570003566	Mg2+ binding site [ion binding]; other site
457570003567	G-X-G motif; other site
457570003568	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
457570003569	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570003570	Radical SAM superfamily; Region: Radical_SAM; pfam04055
457570003571	FeS/SAM binding site; other site
457570003572	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
457570003573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570003574	S-adenosylmethionine binding site [chemical binding]; other site
457570003575	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
457570003576	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
457570003577	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
457570003578	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
457570003579	active site
457570003580	DNA binding site [nucleotide binding]
457570003581	Int/Topo IB signature motif; other site
457570003582	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
457570003583	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
457570003584	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570003585	salt bridge; other site
457570003586	non-specific DNA binding site [nucleotide binding]; other site
457570003587	sequence-specific DNA binding site [nucleotide binding]; other site
457570003588	Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649
457570003589	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cd00525
457570003590	nucleotide binding site [chemical binding]; other site
457570003591	large terminase protein; Provisional; Region: 17; PHA02533
457570003592	Terminase-like family; Region: Terminase_6; pfam03237
457570003593	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
457570003594	putative ADP-ribose binding site [chemical binding]; other site
457570003595	putative active site [active]
457570003596	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
457570003597	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
457570003598	putative dimer interface [polypeptide binding]; other site
457570003599	[2Fe-2S] cluster binding site [ion binding]; other site
457570003600	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
457570003601	dimer interface [polypeptide binding]; other site
457570003602	[2Fe-2S] cluster binding site [ion binding]; other site
457570003603	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
457570003604	SLBB domain; Region: SLBB; pfam10531
457570003605	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
457570003606	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
457570003607	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
457570003608	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
457570003609	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
457570003610	catalytic loop [active]
457570003611	iron binding site [ion binding]; other site
457570003612	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
457570003613	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570003614	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
457570003615	molybdopterin cofactor binding site; other site
457570003616	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
457570003617	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
457570003618	DRTGG domain; Region: DRTGG; pfam07085
457570003619	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
457570003620	DHH family; Region: DHH; pfam01368
457570003621	DHHA2 domain; Region: DHHA2; pfam02833
457570003622	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
457570003623	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
457570003624	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
457570003625	active site
457570003626	HIGH motif; other site
457570003627	KMSK motif region; other site
457570003628	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
457570003629	tRNA binding surface [nucleotide binding]; other site
457570003630	anticodon binding site; other site
457570003631	Uncharacterized conserved protein [Function unknown]; Region: COG1751
457570003632	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
457570003633	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
457570003634	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
457570003635	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
457570003636	substrate binding pocket [chemical binding]; other site
457570003637	chain length determination region; other site
457570003638	substrate-Mg2+ binding site; other site
457570003639	catalytic residues [active]
457570003640	aspartate-rich region 1; other site
457570003641	active site lid residues [active]
457570003642	aspartate-rich region 2; other site
457570003643	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
457570003644	hypothetical protein; Provisional; Region: PRK06851
457570003645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570003646	Walker A motif; other site
457570003647	ATP binding site [chemical binding]; other site
457570003648	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
457570003649	Methyltransferase domain; Region: Methyltransf_31; pfam13847
457570003650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570003651	S-adenosylmethionine binding site [chemical binding]; other site
457570003652	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
457570003653	Rubredoxin; Region: Rubredoxin; pfam00301
457570003654	iron binding site [ion binding]; other site
457570003655	Protein of unknown function (DUF503); Region: DUF503; pfam04456
457570003656	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
457570003657	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
457570003658	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
457570003659	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
457570003660	catalytic residues [active]
457570003661	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
457570003662	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
457570003663	GTP binding site; other site
457570003664	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
457570003665	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570003666	FeS/SAM binding site; other site
457570003667	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
457570003668	MOSC domain; Region: MOSC; pfam03473
457570003669	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
457570003670	Walker A motif; other site
457570003671	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
457570003672	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
457570003673	Walker A; other site
457570003674	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
457570003675	G4 box; other site
457570003676	G5 box; other site
457570003677	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
457570003678	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
457570003679	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
457570003680	putative homodimer interface [polypeptide binding]; other site
457570003681	putative homotetramer interface [polypeptide binding]; other site
457570003682	allosteric switch controlling residues; other site
457570003683	putative metal binding site [ion binding]; other site
457570003684	putative homodimer-homodimer interface [polypeptide binding]; other site
457570003685	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
457570003686	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
457570003687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570003688	homodimer interface [polypeptide binding]; other site
457570003689	catalytic residue [active]
457570003690	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
457570003691	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
457570003692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
457570003693	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
457570003694	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
457570003695	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
457570003696	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
457570003697	Predicted transcriptional regulator [Transcription]; Region: COG1959
457570003698	Transcriptional regulator; Region: Rrf2; cl17282
457570003699	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
457570003700	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
457570003701	DNA binding site [nucleotide binding]
457570003702	active site
457570003703	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
457570003704	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
457570003705	Tetramer interface [polypeptide binding]; other site
457570003706	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
457570003707	active site
457570003708	FMN-binding site [chemical binding]; other site
457570003709	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
457570003710	active site
457570003711	dimer interface [polypeptide binding]; other site
457570003712	metal binding site [ion binding]; metal-binding site
457570003713	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
457570003714	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570003715	Walker A/P-loop; other site
457570003716	ATP binding site [chemical binding]; other site
457570003717	Q-loop/lid; other site
457570003718	ABC transporter signature motif; other site
457570003719	Walker B; other site
457570003720	D-loop; other site
457570003721	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
457570003722	protein-export membrane protein SecD; Region: secD; TIGR01129
457570003723	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
457570003724	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
457570003725	Protein export membrane protein; Region: SecD_SecF; pfam02355
457570003726	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
457570003727	DHH family; Region: DHH; pfam01368
457570003728	DHHA1 domain; Region: DHHA1; pfam02272
457570003729	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
457570003730	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
457570003731	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570003732	Zn2+ binding site [ion binding]; other site
457570003733	Mg2+ binding site [ion binding]; other site
457570003734	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
457570003735	synthetase active site [active]
457570003736	NTP binding site [chemical binding]; other site
457570003737	metal binding site [ion binding]; metal-binding site
457570003738	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
457570003739	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
457570003740	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
457570003741	putative active site [active]
457570003742	dimerization interface [polypeptide binding]; other site
457570003743	putative tRNAtyr binding site [nucleotide binding]; other site
457570003744	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
457570003745	T-box leader as predicted by Rfam (RF00230), score 88.60; T-box leader sequence
457570003746	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
457570003747	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
457570003748	dimer interface [polypeptide binding]; other site
457570003749	motif 1; other site
457570003750	active site
457570003751	motif 2; other site
457570003752	motif 3; other site
457570003753	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
457570003754	anticodon binding site; other site
457570003755	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
457570003756	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
457570003757	dimer interface [polypeptide binding]; other site
457570003758	anticodon binding site; other site
457570003759	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
457570003760	homodimer interface [polypeptide binding]; other site
457570003761	motif 1; other site
457570003762	active site
457570003763	motif 2; other site
457570003764	GAD domain; Region: GAD; pfam02938
457570003765	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
457570003766	active site
457570003767	motif 3; other site
457570003768	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
457570003769	putative homodimer interface [polypeptide binding]; other site
457570003770	putative homotetramer interface [polypeptide binding]; other site
457570003771	putative allosteric switch controlling residues; other site
457570003772	putative metal binding site [ion binding]; other site
457570003773	putative homodimer-homodimer interface [polypeptide binding]; other site
457570003774	cell division protein MraZ; Reviewed; Region: PRK00326
457570003775	MraZ protein; Region: MraZ; pfam02381
457570003776	MraZ protein; Region: MraZ; pfam02381
457570003777	MraW methylase family; Region: Methyltransf_5; cl17771
457570003778	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
457570003779	Cell division protein FtsL; Region: FtsL; cl11433
457570003780	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
457570003781	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
457570003782	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
457570003783	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
457570003784	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
457570003785	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
457570003786	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
457570003787	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
457570003788	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
457570003789	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
457570003790	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
457570003791	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
457570003792	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
457570003793	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
457570003794	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
457570003795	Mg++ binding site [ion binding]; other site
457570003796	putative catalytic motif [active]
457570003797	putative substrate binding site [chemical binding]; other site
457570003798	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
457570003799	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
457570003800	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
457570003801	cell division protein FtsW; Region: ftsW; TIGR02614
457570003802	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
457570003803	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
457570003804	active site
457570003805	homodimer interface [polypeptide binding]; other site
457570003806	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
457570003807	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
457570003808	hinge; other site
457570003809	active site
457570003810	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
457570003811	Cell division protein FtsQ; Region: FtsQ; pfam03799
457570003812	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
457570003813	Cell division protein FtsA; Region: FtsA; smart00842
457570003814	Cell division protein FtsA; Region: FtsA; pfam14450
457570003815	cell division protein FtsZ; Validated; Region: PRK09330
457570003816	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
457570003817	nucleotide binding site [chemical binding]; other site
457570003818	SulA interaction site; other site
457570003819	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
457570003820	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
457570003821	sporulation sigma factor SigE; Reviewed; Region: PRK08301
457570003822	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570003823	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570003824	DNA binding residues [nucleotide binding]
457570003825	sporulation sigma factor SigG; Reviewed; Region: PRK08215
457570003826	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570003827	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
457570003828	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570003829	DNA binding residues [nucleotide binding]
457570003830	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
457570003831	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
457570003832	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
457570003833	HlyD family secretion protein; Region: HlyD_2; pfam12700
457570003834	putative membrane fusion protein; Region: TIGR02828
457570003835	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
457570003836	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
457570003837	catalytic residue [active]
457570003838	Protein of unknown function (DUF552); Region: DUF552; pfam04472
457570003839	YGGT family; Region: YGGT; pfam02325
457570003840	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
457570003841	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
457570003842	RNA binding surface [nucleotide binding]; other site
457570003843	DivIVA protein; Region: DivIVA; pfam05103
457570003844	DivIVA domain; Region: DivI1A_domain; TIGR03544
457570003845	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
457570003846	T-box leader as predicted by Rfam (RF00230), score 118.28; T-box leader sequence
457570003847	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
457570003848	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
457570003849	HIGH motif; other site
457570003850	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
457570003851	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
457570003852	active site
457570003853	KMSKS motif; other site
457570003854	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
457570003855	tRNA binding surface [nucleotide binding]; other site
457570003856	anticodon binding site; other site
457570003857	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
457570003858	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
457570003859	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
457570003860	lipoprotein signal peptidase; Provisional; Region: PRK14787
457570003861	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
457570003862	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
457570003863	RNA binding surface [nucleotide binding]; other site
457570003864	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
457570003865	active site
457570003866	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
457570003867	Domain of unknown function (DUF814); Region: DUF814; pfam05670
457570003868	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
457570003869	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
457570003870	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
457570003871	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
457570003872	Soluble P-type ATPase [General function prediction only]; Region: COG4087
457570003873	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
457570003874	hypothetical protein; Provisional; Region: PRK11820
457570003875	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
457570003876	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
457570003877	hypothetical protein; Provisional; Region: PRK04323
457570003878	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
457570003879	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
457570003880	catalytic site [active]
457570003881	G-X2-G-X-G-K; other site
457570003882	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
457570003883	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
457570003884	Flavoprotein; Region: Flavoprotein; pfam02441
457570003885	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
457570003886	primosome assembly protein PriA; Validated; Region: PRK05580
457570003887	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
457570003888	ATP binding site [chemical binding]; other site
457570003889	putative Mg++ binding site [ion binding]; other site
457570003890	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
457570003891	nucleotide binding region [chemical binding]; other site
457570003892	ATP-binding site [chemical binding]; other site
457570003893	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
457570003894	active site
457570003895	catalytic residues [active]
457570003896	metal binding site [ion binding]; metal-binding site
457570003897	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
457570003898	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
457570003899	putative active site [active]
457570003900	substrate binding site [chemical binding]; other site
457570003901	putative cosubstrate binding site; other site
457570003902	catalytic site [active]
457570003903	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
457570003904	substrate binding site [chemical binding]; other site
457570003905	Protein of unknown function DUF116; Region: DUF116; pfam01976
457570003906	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
457570003907	16S rRNA methyltransferase B; Provisional; Region: PRK14902
457570003908	NusB family; Region: NusB; pfam01029
457570003909	putative RNA binding site [nucleotide binding]; other site
457570003910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570003911	S-adenosylmethionine binding site [chemical binding]; other site
457570003912	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
457570003913	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570003914	FeS/SAM binding site; other site
457570003915	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
457570003916	active site
457570003917	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
457570003918	Catalytic domain of Protein Kinases; Region: PKc; cd00180
457570003919	active site
457570003920	ATP binding site [chemical binding]; other site
457570003921	substrate binding site [chemical binding]; other site
457570003922	activation loop (A-loop); other site
457570003923	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
457570003924	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
457570003925	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
457570003926	GTPase RsgA; Reviewed; Region: PRK00098
457570003927	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
457570003928	RNA binding site [nucleotide binding]; other site
457570003929	homodimer interface [polypeptide binding]; other site
457570003930	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
457570003931	GTPase/Zn-binding domain interface [polypeptide binding]; other site
457570003932	GTP/Mg2+ binding site [chemical binding]; other site
457570003933	G4 box; other site
457570003934	G5 box; other site
457570003935	G1 box; other site
457570003936	Switch I region; other site
457570003937	G2 box; other site
457570003938	G3 box; other site
457570003939	Switch II region; other site
457570003940	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
457570003941	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
457570003942	substrate binding site [chemical binding]; other site
457570003943	hexamer interface [polypeptide binding]; other site
457570003944	metal binding site [ion binding]; metal-binding site
457570003945	ribosomal protein L28; Region: L28; TIGR00009
457570003946	Asp23 family; Region: Asp23; pfam03780
457570003947	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
457570003948	DAK2 domain; Region: Dak2; pfam02734
457570003949	EDD domain protein, DegV family; Region: DegV; TIGR00762
457570003950	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
457570003951	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
457570003952	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
457570003953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570003954	S-adenosylmethionine binding site [chemical binding]; other site
457570003955	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
457570003956	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
457570003957	active site
457570003958	(T/H)XGH motif; other site
457570003959	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
457570003960	Nucleoside recognition; Region: Gate; pfam07670
457570003961	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
457570003962	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
457570003963	nucleophile elbow; other site
457570003964	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
457570003965	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
457570003966	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
457570003967	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
457570003968	hypothetical protein; Provisional; Region: PRK13670
457570003969	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
457570003970	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
457570003971	putative phosphate acyltransferase; Provisional; Region: PRK05331
457570003972	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
457570003973	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
457570003974	dimer interface [polypeptide binding]; other site
457570003975	active site
457570003976	CoA binding pocket [chemical binding]; other site
457570003977	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
457570003978	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
457570003979	FMN binding site [chemical binding]; other site
457570003980	substrate binding site [chemical binding]; other site
457570003981	putative catalytic residue [active]
457570003982	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
457570003983	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
457570003984	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
457570003985	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
457570003986	NAD(P) binding site [chemical binding]; other site
457570003987	homotetramer interface [polypeptide binding]; other site
457570003988	homodimer interface [polypeptide binding]; other site
457570003989	active site
457570003990	acyl carrier protein; Provisional; Region: acpP; PRK00982
457570003991	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
457570003992	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
457570003993	dimer interface [polypeptide binding]; other site
457570003994	active site
457570003995	ribonuclease III; Reviewed; Region: rnc; PRK00102
457570003996	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
457570003997	dimerization interface [polypeptide binding]; other site
457570003998	active site
457570003999	metal binding site [ion binding]; metal-binding site
457570004000	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
457570004001	dsRNA binding site [nucleotide binding]; other site
457570004002	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
457570004003	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
457570004004	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
457570004005	Walker A/P-loop; other site
457570004006	ATP binding site [chemical binding]; other site
457570004007	Q-loop/lid; other site
457570004008	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
457570004009	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
457570004010	ABC transporter signature motif; other site
457570004011	Walker B; other site
457570004012	D-loop; other site
457570004013	H-loop/switch region; other site
457570004014	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
457570004015	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
457570004016	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
457570004017	P loop; other site
457570004018	GTP binding site [chemical binding]; other site
457570004019	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
457570004020	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570004021	DNA binding residues [nucleotide binding]
457570004022	signal recognition particle protein; Provisional; Region: PRK10867
457570004023	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
457570004024	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
457570004025	P loop; other site
457570004026	GTP binding site [chemical binding]; other site
457570004027	Signal peptide binding domain; Region: SRP_SPB; pfam02978
457570004028	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
457570004029	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
457570004030	hypothetical protein; Provisional; Region: PRK00468
457570004031	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
457570004032	RimM N-terminal domain; Region: RimM; pfam01782
457570004033	PRC-barrel domain; Region: PRC; pfam05239
457570004034	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
457570004035	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
457570004036	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
457570004037	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
457570004038	Catalytic site [active]
457570004039	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
457570004040	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
457570004041	RNA/DNA hybrid binding site [nucleotide binding]; other site
457570004042	active site
457570004043	hypothetical protein; Reviewed; Region: PRK12497
457570004044	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
457570004045	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
457570004046	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570004047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
457570004048	Walker A motif; other site
457570004049	ATP binding site [chemical binding]; other site
457570004050	Ubiquitin-activating enzyme e1 C-terminal domain; Region: UBA_e1_C; cl09615
457570004051	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
457570004052	Predicted membrane protein [Function unknown]; Region: COG4129
457570004053	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
457570004054	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
457570004055	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
457570004056	active site
457570004057	dimer interface [polypeptide binding]; other site
457570004058	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
457570004059	Ligand Binding Site [chemical binding]; other site
457570004060	Molecular Tunnel; other site
457570004061	DNA protecting protein DprA; Region: dprA; TIGR00732
457570004062	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
457570004063	DNA topoisomerase I; Validated; Region: PRK05582
457570004064	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
457570004065	active site
457570004066	interdomain interaction site; other site
457570004067	putative metal-binding site [ion binding]; other site
457570004068	nucleotide binding site [chemical binding]; other site
457570004069	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
457570004070	domain I; other site
457570004071	DNA binding groove [nucleotide binding]
457570004072	phosphate binding site [ion binding]; other site
457570004073	domain II; other site
457570004074	domain III; other site
457570004075	nucleotide binding site [chemical binding]; other site
457570004076	catalytic site [active]
457570004077	domain IV; other site
457570004078	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
457570004079	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
457570004080	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
457570004081	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
457570004082	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
457570004083	Glucose inhibited division protein A; Region: GIDA; pfam01134
457570004084	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
457570004085	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
457570004086	active site
457570004087	Int/Topo IB signature motif; other site
457570004088	ATP-dependent protease subunit HslV; Provisional; Region: PRK05456
457570004089	active site
457570004090	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
457570004091	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
457570004092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570004093	Walker A motif; other site
457570004094	ATP binding site [chemical binding]; other site
457570004095	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
457570004096	Walker B motif; other site
457570004097	arginine finger; other site
457570004098	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
457570004099	transcriptional repressor CodY; Validated; Region: PRK04158
457570004100	CodY GAF-like domain; Region: CodY; pfam06018
457570004101	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
457570004102	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570004103	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570004104	putative active site [active]
457570004105	putative NTP binding site [chemical binding]; other site
457570004106	putative nucleic acid binding site [nucleotide binding]; other site
457570004107	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570004108	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
457570004109	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
457570004110	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
457570004111	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
457570004112	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
457570004113	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
457570004114	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
457570004115	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
457570004116	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
457570004117	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
457570004118	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
457570004119	FliG C-terminal domain; Region: FliG_C; pfam01706
457570004120	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
457570004121	Flagellar assembly protein FliH; Region: FliH; pfam02108
457570004122	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
457570004123	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
457570004124	Walker A motif/ATP binding site; other site
457570004125	Walker B motif; other site
457570004126	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
457570004127	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720
457570004128	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
457570004129	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
457570004130	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
457570004131	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
457570004132	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
457570004133	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
457570004134	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
457570004135	Flagellar protein (FlbD); Region: FlbD; pfam06289
457570004136	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
457570004137	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
457570004138	flagellar motor protein MotS; Reviewed; Region: PRK06925
457570004139	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
457570004140	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
457570004141	ligand binding site [chemical binding]; other site
457570004142	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
457570004143	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
457570004144	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
457570004145	flagellar motor switch protein; Validated; Region: PRK08119
457570004146	CheC-like family; Region: CheC; pfam04509
457570004147	CheC-like family; Region: CheC; pfam04509
457570004148	flagellar motor switch protein FliN; Region: fliN; TIGR02480
457570004149	Response regulator receiver domain; Region: Response_reg; pfam00072
457570004150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570004151	active site
457570004152	phosphorylation site [posttranslational modification]
457570004153	intermolecular recognition site; other site
457570004154	dimerization interface [polypeptide binding]; other site
457570004155	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
457570004156	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
457570004157	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
457570004158	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
457570004159	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
457570004160	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
457570004161	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
457570004162	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
457570004163	FHIPEP family; Region: FHIPEP; pfam00771
457570004164	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
457570004165	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
457570004166	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
457570004167	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
457570004168	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
457570004169	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
457570004170	Flagellar protein YcgR; Region: YcgR_2; pfam12945
457570004171	PilZ domain; Region: PilZ; pfam07238
457570004172	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
457570004173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570004174	active site
457570004175	phosphorylation site [posttranslational modification]
457570004176	intermolecular recognition site; other site
457570004177	dimerization interface [polypeptide binding]; other site
457570004178	CheB methylesterase; Region: CheB_methylest; pfam01339
457570004179	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
457570004180	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
457570004181	putative binding surface; other site
457570004182	active site
457570004183	P2 response regulator binding domain; Region: P2; pfam07194
457570004184	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
457570004185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570004186	ATP binding site [chemical binding]; other site
457570004187	Mg2+ binding site [ion binding]; other site
457570004188	G-X-G motif; other site
457570004189	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
457570004190	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
457570004191	putative CheA interaction surface; other site
457570004192	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
457570004193	CheC-like family; Region: CheC; pfam04509
457570004194	CheC-like family; Region: CheC; pfam04509
457570004195	Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871
457570004196	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
457570004197	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570004198	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
457570004199	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570004200	DNA binding residues [nucleotide binding]
457570004201	Protein of unknown function (DUF342); Region: DUF342; pfam03961
457570004202	YceG-like family; Region: YceG; pfam02618
457570004203	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
457570004204	rRNA interaction site [nucleotide binding]; other site
457570004205	S8 interaction site; other site
457570004206	putative laminin-1 binding site; other site
457570004207	elongation factor Ts; Reviewed; Region: tsf; PRK12332
457570004208	UBA/TS-N domain; Region: UBA; pfam00627
457570004209	Elongation factor TS; Region: EF_TS; pfam00889
457570004210	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
457570004211	putative nucleotide binding site [chemical binding]; other site
457570004212	uridine monophosphate binding site [chemical binding]; other site
457570004213	homohexameric interface [polypeptide binding]; other site
457570004214	ribosome recycling factor; Reviewed; Region: frr; PRK00083
457570004215	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
457570004216	hinge region; other site
457570004217	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
457570004218	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
457570004219	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
457570004220	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
457570004221	catalytic residue [active]
457570004222	putative FPP diphosphate  binding site; other site
457570004223	putative FPP binding hydrophobic cleft; other site
457570004224	dimer interface [polypeptide binding]; other site
457570004225	putative IPP diphosphate binding site; other site
457570004226	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
457570004227	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
457570004228	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
457570004229	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
457570004230	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
457570004231	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
457570004232	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
457570004233	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
457570004234	active site
457570004235	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
457570004236	protein binding site [polypeptide binding]; other site
457570004237	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
457570004238	putative substrate binding region [chemical binding]; other site
457570004239	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
457570004240	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
457570004241	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
457570004242	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
457570004243	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
457570004244	Ligand binding site; other site
457570004245	Putative Catalytic site; other site
457570004246	DXD motif; other site
457570004247	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
457570004248	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
457570004249	generic binding surface II; other site
457570004250	generic binding surface I; other site
457570004251	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
457570004252	PHP domain; Region: PHP; pfam02811
457570004253	active site
457570004254	putative PHP Thumb interface [polypeptide binding]; other site
457570004255	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
457570004256	ribosome maturation protein RimP; Reviewed; Region: PRK00092
457570004257	Sm and related proteins; Region: Sm_like; cl00259
457570004258	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
457570004259	putative oligomer interface [polypeptide binding]; other site
457570004260	putative RNA binding site [nucleotide binding]; other site
457570004261	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
457570004262	NusA N-terminal domain; Region: NusA_N; pfam08529
457570004263	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
457570004264	RNA binding site [nucleotide binding]; other site
457570004265	homodimer interface [polypeptide binding]; other site
457570004266	NusA-like KH domain; Region: KH_5; pfam13184
457570004267	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
457570004268	G-X-X-G motif; other site
457570004269	Protein of unknown function (DUF448); Region: DUF448; pfam04296
457570004270	putative RNA binding cleft [nucleotide binding]; other site
457570004271	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
457570004272	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
457570004273	translation initiation factor IF-2; Region: IF-2; TIGR00487
457570004274	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
457570004275	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
457570004276	G1 box; other site
457570004277	putative GEF interaction site [polypeptide binding]; other site
457570004278	GTP/Mg2+ binding site [chemical binding]; other site
457570004279	Switch I region; other site
457570004280	G2 box; other site
457570004281	G3 box; other site
457570004282	Switch II region; other site
457570004283	G4 box; other site
457570004284	G5 box; other site
457570004285	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
457570004286	Translation-initiation factor 2; Region: IF-2; pfam11987
457570004287	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
457570004288	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
457570004289	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
457570004290	DHH family; Region: DHH; pfam01368
457570004291	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
457570004292	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
457570004293	RNA binding site [nucleotide binding]; other site
457570004294	active site
457570004295	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
457570004296	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
457570004297	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
457570004298	active site
457570004299	Riboflavin kinase; Region: Flavokinase; pfam01687
457570004300	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
457570004301	16S/18S rRNA binding site [nucleotide binding]; other site
457570004302	S13e-L30e interaction site [polypeptide binding]; other site
457570004303	25S rRNA binding site [nucleotide binding]; other site
457570004304	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
457570004305	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
457570004306	RNase E interface [polypeptide binding]; other site
457570004307	trimer interface [polypeptide binding]; other site
457570004308	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
457570004309	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
457570004310	RNase E interface [polypeptide binding]; other site
457570004311	trimer interface [polypeptide binding]; other site
457570004312	active site
457570004313	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
457570004314	putative nucleic acid binding region [nucleotide binding]; other site
457570004315	G-X-X-G motif; other site
457570004316	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
457570004317	RNA binding site [nucleotide binding]; other site
457570004318	domain interface; other site
457570004319	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
457570004320	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
457570004321	NodB motif; other site
457570004322	VanW like protein; Region: VanW; pfam04294
457570004323	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
457570004324	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
457570004325	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
457570004326	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570004327	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570004328	putative active site [active]
457570004329	putative NTP binding site [chemical binding]; other site
457570004330	putative nucleic acid binding site [nucleotide binding]; other site
457570004331	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570004332	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
457570004333	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
457570004334	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
457570004335	aspartate kinase I; Reviewed; Region: PRK08210
457570004336	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
457570004337	putative catalytic residues [active]
457570004338	putative nucleotide binding site [chemical binding]; other site
457570004339	putative aspartate binding site [chemical binding]; other site
457570004340	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like; cd04868
457570004341	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
457570004342	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
457570004343	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
457570004344	dimer interface [polypeptide binding]; other site
457570004345	active site
457570004346	catalytic residue [active]
457570004347	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
457570004348	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
457570004349	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
457570004350	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
457570004351	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
457570004352	active site
457570004353	YlzJ-like protein; Region: YlzJ; pfam14035
457570004354	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570004355	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570004356	putative active site [active]
457570004357	putative NTP binding site [chemical binding]; other site
457570004358	putative nucleic acid binding site [nucleotide binding]; other site
457570004359	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570004360	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
457570004361	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
457570004362	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
457570004363	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
457570004364	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
457570004365	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
457570004366	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570004367	non-specific DNA binding site [nucleotide binding]; other site
457570004368	salt bridge; other site
457570004369	sequence-specific DNA binding site [nucleotide binding]; other site
457570004370	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
457570004371	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
457570004372	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570004373	FeS/SAM binding site; other site
457570004374	TRAM domain; Region: TRAM; cl01282
457570004375	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
457570004376	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
457570004377	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570004378	Walker A motif; other site
457570004379	ATP binding site [chemical binding]; other site
457570004380	Walker B motif; other site
457570004381	arginine finger; other site
457570004382	Peptidase family M41; Region: Peptidase_M41; pfam01434
457570004383	competence damage-inducible protein A; Provisional; Region: PRK00549
457570004384	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
457570004385	putative MPT binding site; other site
457570004386	Competence-damaged protein; Region: CinA; pfam02464
457570004387	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
457570004388	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
457570004389	active site
457570004390	metal binding site [ion binding]; metal-binding site
457570004391	recombinase A; Provisional; Region: recA; PRK09354
457570004392	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
457570004393	hexamer interface [polypeptide binding]; other site
457570004394	Walker A motif; other site
457570004395	ATP binding site [chemical binding]; other site
457570004396	Walker B motif; other site
457570004397	recombination regulator RecX; Reviewed; Region: recX; PRK00117
457570004398	phosphodiesterase; Provisional; Region: PRK12704
457570004399	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570004400	Zn2+ binding site [ion binding]; other site
457570004401	Mg2+ binding site [ion binding]; other site
457570004402	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
457570004403	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
457570004404	putative active site [active]
457570004405	metal binding site [ion binding]; metal-binding site
457570004406	homodimer binding site [polypeptide binding]; other site
457570004407	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
457570004408	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
457570004409	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
457570004410	active site
457570004411	dimer interface [polypeptide binding]; other site
457570004412	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
457570004413	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
457570004414	active site
457570004415	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
457570004416	Predicted transcriptional regulators [Transcription]; Region: COG1725
457570004417	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
457570004418	DNA-binding site [nucleotide binding]; DNA binding site
457570004419	Ferredoxin [Energy production and conversion]; Region: COG1146
457570004420	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
457570004421	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
457570004422	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
457570004423	dimer interface [polypeptide binding]; other site
457570004424	PYR/PP interface [polypeptide binding]; other site
457570004425	TPP binding site [chemical binding]; other site
457570004426	substrate binding site [chemical binding]; other site
457570004427	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
457570004428	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
457570004429	TPP-binding site [chemical binding]; other site
457570004430	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
457570004431	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
457570004432	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
457570004433	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
457570004434	NAD(P) binding site [chemical binding]; other site
457570004435	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
457570004436	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
457570004437	B12 binding site [chemical binding]; other site
457570004438	cobalt ligand [ion binding]; other site
457570004439	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
457570004440	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
457570004441	dimer interface [polypeptide binding]; other site
457570004442	substrate binding site [chemical binding]; other site
457570004443	metal binding site [ion binding]; metal-binding site
457570004444	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
457570004445	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
457570004446	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
457570004447	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
457570004448	DHHW protein; Region: DHHW; pfam14286
457570004449	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
457570004450	carboxyltransferase (CT) interaction site; other site
457570004451	biotinylation site [posttranslational modification]; other site
457570004452	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
457570004453	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
457570004454	VanW like protein; Region: VanW; pfam04294
457570004455	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
457570004456	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
457570004457	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570004458	FeS/SAM binding site; other site
457570004459	TRAM domain; Region: TRAM; pfam01938
457570004460	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
457570004461	MutS domain I; Region: MutS_I; pfam01624
457570004462	MutS domain II; Region: MutS_II; pfam05188
457570004463	MutS domain III; Region: MutS_III; pfam05192
457570004464	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
457570004465	Walker A/P-loop; other site
457570004466	ATP binding site [chemical binding]; other site
457570004467	Q-loop/lid; other site
457570004468	ABC transporter signature motif; other site
457570004469	Walker B; other site
457570004470	D-loop; other site
457570004471	H-loop/switch region; other site
457570004472	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
457570004473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570004474	ATP binding site [chemical binding]; other site
457570004475	Mg2+ binding site [ion binding]; other site
457570004476	G-X-G motif; other site
457570004477	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
457570004478	ATP binding site [chemical binding]; other site
457570004479	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
457570004480	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
457570004481	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
457570004482	bacterial Hfq-like; Region: Hfq; cd01716
457570004483	hexamer interface [polypeptide binding]; other site
457570004484	Sm1 motif; other site
457570004485	RNA binding site [nucleotide binding]; other site
457570004486	Sm2 motif; other site
457570004487	CAAX protease self-immunity; Region: Abi; pfam02517
457570004488	stage V sporulation protein K; Region: spore_V_K; TIGR02881
457570004489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570004490	Walker A motif; other site
457570004491	ATP binding site [chemical binding]; other site
457570004492	Walker B motif; other site
457570004493	arginine finger; other site
457570004494	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
457570004495	Aluminium resistance protein; Region: Alum_res; pfam06838
457570004496	LexA repressor; Validated; Region: PRK00215
457570004497	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
457570004498	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
457570004499	Catalytic site [active]
457570004500	LysM domain; Region: LysM; pfam01476
457570004501	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570004502	Transposase; Region: HTH_Tnp_1; pfam01527
457570004503	Catalytic domain of Protein Kinases; Region: PKc; cd00180
457570004504	active site
457570004505	ATP binding site [chemical binding]; other site
457570004506	substrate binding site [chemical binding]; other site
457570004507	activation loop (A-loop); other site
457570004508	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
457570004509	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
457570004510	GIY-YIG motif/motif A; other site
457570004511	active site
457570004512	catalytic site [active]
457570004513	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
457570004514	Part of AAA domain; Region: AAA_19; pfam13245
457570004515	Family description; Region: UvrD_C_2; pfam13538
457570004516	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
457570004517	AAA domain; Region: AAA_23; pfam13476
457570004518	AAA domain; Region: AAA_21; pfam13304
457570004519	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
457570004520	putative active site [active]
457570004521	putative metal-binding site [ion binding]; other site
457570004522	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
457570004523	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
457570004524	active site
457570004525	DNA binding site [nucleotide binding]
457570004526	Int/Topo IB signature motif; other site
457570004527	Catalytic domain of Protein Kinases; Region: PKc; cd00180
457570004528	active site
457570004529	ATP binding site [chemical binding]; other site
457570004530	substrate binding site [chemical binding]; other site
457570004531	activation loop (A-loop); other site
457570004532	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570004533	ABC transporter signature motif; other site
457570004534	Walker B; other site
457570004535	D-loop; other site
457570004536	H-loop/switch region; other site
457570004537	DEAD-like helicases superfamily; Region: DEXDc; smart00487
457570004538	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
457570004539	ATP binding site [chemical binding]; other site
457570004540	putative Mg++ binding site [ion binding]; other site
457570004541	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
457570004542	nucleotide binding region [chemical binding]; other site
457570004543	ATP-binding site [chemical binding]; other site
457570004544	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
457570004545	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570004546	Transposase; Region: HTH_Tnp_1; pfam01527
457570004547	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570004548	Transposase; Region: HTH_Tnp_1; pfam01527
457570004549	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
457570004550	substrate binding pocket [chemical binding]; other site
457570004551	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
457570004552	Coenzyme A binding pocket [chemical binding]; other site
457570004553	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570004554	PrcB C-terminal; Region: PrcB_C; pfam14343
457570004555	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
457570004556	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
457570004557	PA/protease or protease-like domain interface [polypeptide binding]; other site
457570004558	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
457570004559	Peptidase family M28; Region: Peptidase_M28; pfam04389
457570004560	metal binding site [ion binding]; metal-binding site
457570004561	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
457570004562	Peptidase family M23; Region: Peptidase_M23; pfam01551
457570004563	PQQ-like domain; Region: PQQ_2; pfam13360
457570004564	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
457570004565	Trp docking motif [polypeptide binding]; other site
457570004566	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
457570004567	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570004568	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
457570004569	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
457570004570	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
457570004571	metal binding site [ion binding]; metal-binding site
457570004572	substrate binding pocket [chemical binding]; other site
457570004573	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
457570004574	Carbon starvation protein CstA; Region: CstA; pfam02554
457570004575	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
457570004576	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
457570004577	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
457570004578	catalytic residue [active]
457570004579	KWG Leptospira; Region: KWG; pfam07656
457570004580	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
457570004581	Coenzyme A binding pocket [chemical binding]; other site
457570004582	Rhomboid family; Region: Rhomboid; pfam01694
457570004583	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
457570004584	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
457570004585	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570004586	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570004587	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
457570004588	FMN binding site [chemical binding]; other site
457570004589	dimer interface [polypeptide binding]; other site
457570004590	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
457570004591	dimer interface [polypeptide binding]; other site
457570004592	Restriction endonuclease; Region: Mrr_cat; pfam04471
457570004593	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
457570004594	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
457570004595	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
457570004596	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
457570004597	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
457570004598	Walker A/P-loop; other site
457570004599	ATP binding site [chemical binding]; other site
457570004600	Q-loop/lid; other site
457570004601	ABC transporter signature motif; other site
457570004602	Walker B; other site
457570004603	D-loop; other site
457570004604	H-loop/switch region; other site
457570004605	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
457570004606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570004607	active site
457570004608	phosphorylation site [posttranslational modification]
457570004609	intermolecular recognition site; other site
457570004610	dimerization interface [polypeptide binding]; other site
457570004611	LytTr DNA-binding domain; Region: LytTR; pfam04397
457570004612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570004613	ATP binding site [chemical binding]; other site
457570004614	Mg2+ binding site [ion binding]; other site
457570004615	G-X-G motif; other site
457570004616	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
457570004617	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
457570004618	active site
457570004619	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
457570004620	galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288
457570004621	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
457570004622	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
457570004623	NAD binding site [chemical binding]; other site
457570004624	homodimer interface [polypeptide binding]; other site
457570004625	active site
457570004626	substrate binding site [chemical binding]; other site
457570004627	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
457570004628	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
457570004629	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
457570004630	putative trimer interface [polypeptide binding]; other site
457570004631	putative CoA binding site [chemical binding]; other site
457570004632	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
457570004633	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
457570004634	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
457570004635	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
457570004636	active site
457570004637	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
457570004638	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
457570004639	active site
457570004640	substrate binding site [chemical binding]; other site
457570004641	ATP binding site [chemical binding]; other site
457570004642	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
457570004643	Phosphotransferase enzyme family; Region: APH; pfam01636
457570004644	active site
457570004645	substrate binding site [chemical binding]; other site
457570004646	ATP binding site [chemical binding]; other site
457570004647	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
457570004648	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
457570004649	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
457570004650	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
457570004651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
457570004652	NAD(P) binding site [chemical binding]; other site
457570004653	active site
457570004654	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
457570004655	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
457570004656	active site
457570004657	tetramer interface; other site
457570004658	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
457570004659	DNA-binding site [nucleotide binding]; DNA binding site
457570004660	RNA-binding motif; other site
457570004661	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
457570004662	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
457570004663	DNA-binding site [nucleotide binding]; DNA binding site
457570004664	RNA-binding motif; other site
457570004665	Tic20-like protein; Region: Tic20; pfam09685
457570004666	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570004667	Transposase; Region: HTH_Tnp_1; pfam01527
457570004668	Membrane protein of unknown function; Region: DUF360; cl00850
457570004669	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
457570004670	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
457570004671	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570004672	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
457570004673	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
457570004674	intersubunit interface [polypeptide binding]; other site
457570004675	active site
457570004676	catalytic residue [active]
457570004677	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
457570004678	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
457570004679	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
457570004680	active site
457570004681	putative substrate binding pocket [chemical binding]; other site
457570004682	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
457570004683	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
457570004684	binding surface
457570004685	TPR motif; other site
457570004686	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
457570004687	binding surface
457570004688	TPR repeat; Region: TPR_11; pfam13414
457570004689	TPR motif; other site
457570004690	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
457570004691	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
457570004692	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
457570004693	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
457570004694	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
457570004695	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
457570004696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570004697	S-adenosylmethionine binding site [chemical binding]; other site
457570004698	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
457570004699	active site
457570004700	multimer interface [polypeptide binding]; other site
457570004701	phytoene desaturase; Region: crtI_fam; TIGR02734
457570004702	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
457570004703	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
457570004704	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
457570004705	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
457570004706	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
457570004707	Predicted amidohydrolase [General function prediction only]; Region: COG0388
457570004708	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_6; cd07584
457570004709	putative active site [active]
457570004710	catalytic triad [active]
457570004711	putative dimer interface [polypeptide binding]; other site
457570004712	ATP-grasp domain; Region: ATP-grasp_4; cl17255
457570004713	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
457570004714	SurA N-terminal domain; Region: SurA_N_3; cl07813
457570004715	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
457570004716	VPS10 domain; Region: VPS10; smart00602
457570004717	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570004718	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570004719	putative active site [active]
457570004720	putative NTP binding site [chemical binding]; other site
457570004721	putative nucleic acid binding site [nucleotide binding]; other site
457570004722	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570004723	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
457570004724	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
457570004725	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
457570004726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570004727	dimer interface [polypeptide binding]; other site
457570004728	conserved gate region; other site
457570004729	putative PBP binding loops; other site
457570004730	ABC-ATPase subunit interface; other site
457570004731	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
457570004732	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
457570004733	Walker A/P-loop; other site
457570004734	ATP binding site [chemical binding]; other site
457570004735	Q-loop/lid; other site
457570004736	ABC transporter signature motif; other site
457570004737	Walker B; other site
457570004738	D-loop; other site
457570004739	H-loop/switch region; other site
457570004740	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
457570004741	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
457570004742	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
457570004743	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
457570004744	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
457570004745	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
457570004746	active site
457570004747	catalytic triad [active]
457570004748	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
457570004749	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
457570004750	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
457570004751	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
457570004752	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
457570004753	membrane protein; Provisional; Region: PRK14419
457570004754	GTP-binding protein Der; Reviewed; Region: PRK00093
457570004755	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
457570004756	G1 box; other site
457570004757	GTP/Mg2+ binding site [chemical binding]; other site
457570004758	Switch I region; other site
457570004759	G2 box; other site
457570004760	Switch II region; other site
457570004761	G3 box; other site
457570004762	G4 box; other site
457570004763	G5 box; other site
457570004764	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
457570004765	G1 box; other site
457570004766	GTP/Mg2+ binding site [chemical binding]; other site
457570004767	Switch I region; other site
457570004768	G2 box; other site
457570004769	G3 box; other site
457570004770	Switch II region; other site
457570004771	G4 box; other site
457570004772	G5 box; other site
457570004773	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
457570004774	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
457570004775	Protein of unknown function (DUF512); Region: DUF512; pfam04459
457570004776	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
457570004777	YIEGIA protein; Region: YIEGIA; pfam14045
457570004778	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
457570004779	stage II sporulation protein P; Region: spore_II_P; TIGR02867
457570004780	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
457570004781	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
457570004782	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
457570004783	homotetramer interface [polypeptide binding]; other site
457570004784	FMN binding site [chemical binding]; other site
457570004785	homodimer contacts [polypeptide binding]; other site
457570004786	putative active site [active]
457570004787	putative substrate binding site [chemical binding]; other site
457570004788	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
457570004789	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
457570004790	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
457570004791	RNA binding site [nucleotide binding]; other site
457570004792	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
457570004793	RNA binding site [nucleotide binding]; other site
457570004794	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
457570004795	RNA binding site [nucleotide binding]; other site
457570004796	domain interface; other site
457570004797	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
457570004798	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
457570004799	putative acyl-acceptor binding pocket; other site
457570004800	cytidylate kinase; Provisional; Region: cmk; PRK00023
457570004801	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
457570004802	CMP-binding site; other site
457570004803	The sites determining sugar specificity; other site
457570004804	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
457570004805	homotrimer interaction site [polypeptide binding]; other site
457570004806	active site
457570004807	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
457570004808	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
457570004809	RNA binding surface [nucleotide binding]; other site
457570004810	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
457570004811	active site
457570004812	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
457570004813	homotrimer interaction site [polypeptide binding]; other site
457570004814	putative active site [active]
457570004815	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
457570004816	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
457570004817	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
457570004818	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
457570004819	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
457570004820	sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874
457570004821	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
457570004822	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
457570004823	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
457570004824	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
457570004825	Peptidase family M50; Region: Peptidase_M50; pfam02163
457570004826	active site
457570004827	putative substrate binding region [chemical binding]; other site
457570004828	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
457570004829	DHH family; Region: DHH; pfam01368
457570004830	FOG: CBS domain [General function prediction only]; Region: COG0517
457570004831	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
457570004832	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
457570004833	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
457570004834	active site
457570004835	NTP binding site [chemical binding]; other site
457570004836	metal binding triad [ion binding]; metal-binding site
457570004837	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
457570004838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
457570004839	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
457570004840	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
457570004841	stage V sporulation protein AD; Validated; Region: PRK08304
457570004842	stage V sporulation protein AD; Provisional; Region: PRK12404
457570004843	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
457570004844	Dodecin; Region: Dodecin; pfam07311
457570004845	sporulation sigma factor SigF; Validated; Region: PRK05572
457570004846	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570004847	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
457570004848	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
457570004849	DNA binding residues [nucleotide binding]
457570004850	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
457570004851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570004852	ATP binding site [chemical binding]; other site
457570004853	Mg2+ binding site [ion binding]; other site
457570004854	G-X-G motif; other site
457570004855	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
457570004856	anti sigma factor interaction site; other site
457570004857	regulatory phosphorylation site [posttranslational modification]; other site
457570004858	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
457570004859	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
457570004860	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
457570004861	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
457570004862	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
457570004863	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
457570004864	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
457570004865	purine nucleoside phosphorylase; Provisional; Region: PRK08202
457570004866	phosphopentomutase; Provisional; Region: PRK05362
457570004867	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
457570004868	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
457570004869	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
457570004870	active site
457570004871	Int/Topo IB signature motif; other site
457570004872	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
457570004873	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
457570004874	hexamer interface [polypeptide binding]; other site
457570004875	ligand binding site [chemical binding]; other site
457570004876	putative active site [active]
457570004877	NAD(P) binding site [chemical binding]; other site
457570004878	Integral membrane protein DUF95; Region: DUF95; cl00572
457570004879	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
457570004880	PHP-associated; Region: PHP_C; pfam13263
457570004881	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
457570004882	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
457570004883	dimer interface [polypeptide binding]; other site
457570004884	ADP-ribose binding site [chemical binding]; other site
457570004885	active site
457570004886	nudix motif; other site
457570004887	metal binding site [ion binding]; metal-binding site
457570004888	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
457570004889	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
457570004890	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
457570004891	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
457570004892	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
457570004893	TPP-binding site [chemical binding]; other site
457570004894	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
457570004895	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
457570004896	dimer interface [polypeptide binding]; other site
457570004897	PYR/PP interface [polypeptide binding]; other site
457570004898	TPP binding site [chemical binding]; other site
457570004899	substrate binding site [chemical binding]; other site
457570004900	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
457570004901	Ferredoxin [Energy production and conversion]; Region: COG1146
457570004902	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
457570004903	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
457570004904	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
457570004905	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
457570004906	nucleotide binding site [chemical binding]; other site
457570004907	Acetokinase family; Region: Acetate_kinase; cl17229
457570004908	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
457570004909	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
457570004910	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
457570004911	NAD binding site [chemical binding]; other site
457570004912	Phe binding site; other site
457570004913	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
457570004914	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
457570004915	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570004916	putative active site [active]
457570004917	heme pocket [chemical binding]; other site
457570004918	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570004919	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570004920	Walker A motif; other site
457570004921	ATP binding site [chemical binding]; other site
457570004922	Walker B motif; other site
457570004923	arginine finger; other site
457570004924	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
457570004925	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
457570004926	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
457570004927	Ligand binding site; other site
457570004928	Putative Catalytic site; other site
457570004929	DXD motif; other site
457570004930	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
457570004931	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
457570004932	Thiamine pyrophosphokinase; Region: TPK; cl08415
457570004933	active site
457570004934	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
457570004935	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
457570004936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570004937	active site
457570004938	phosphorylation site [posttranslational modification]
457570004939	intermolecular recognition site; other site
457570004940	dimerization interface [polypeptide binding]; other site
457570004941	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
457570004942	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
457570004943	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
457570004944	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
457570004945	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
457570004946	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
457570004947	Walker A/P-loop; other site
457570004948	ATP binding site [chemical binding]; other site
457570004949	Q-loop/lid; other site
457570004950	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
457570004951	ABC transporter signature motif; other site
457570004952	Walker B; other site
457570004953	D-loop; other site
457570004954	H-loop/switch region; other site
457570004955	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
457570004956	ATP-NAD kinase; Region: NAD_kinase; pfam01513
457570004957	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
457570004958	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
457570004959	RNA binding surface [nucleotide binding]; other site
457570004960	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
457570004961	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
457570004962	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
457570004963	TPP-binding site; other site
457570004964	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
457570004965	PYR/PP interface [polypeptide binding]; other site
457570004966	dimer interface [polypeptide binding]; other site
457570004967	TPP binding site [chemical binding]; other site
457570004968	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
457570004969	Divergent PAP2 family; Region: DUF212; pfam02681
457570004970	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
457570004971	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
457570004972	substrate binding pocket [chemical binding]; other site
457570004973	chain length determination region; other site
457570004974	substrate-Mg2+ binding site; other site
457570004975	catalytic residues [active]
457570004976	aspartate-rich region 1; other site
457570004977	active site lid residues [active]
457570004978	aspartate-rich region 2; other site
457570004979	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
457570004980	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
457570004981	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
457570004982	generic binding surface II; other site
457570004983	generic binding surface I; other site
457570004984	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
457570004985	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
457570004986	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
457570004987	homodimer interface [polypeptide binding]; other site
457570004988	NADP binding site [chemical binding]; other site
457570004989	substrate binding site [chemical binding]; other site
457570004990	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
457570004991	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
457570004992	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
457570004993	putative RNA binding site [nucleotide binding]; other site
457570004994	Asp23 family; Region: Asp23; pfam03780
457570004995	Asp23 family; Region: Asp23; pfam03780
457570004996	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
457570004997	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
457570004998	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl17562
457570004999	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546
457570005000	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
457570005001	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
457570005002	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
457570005003	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
457570005004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570005005	Walker A motif; other site
457570005006	ATP binding site [chemical binding]; other site
457570005007	Walker B motif; other site
457570005008	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570005009	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570005010	putative active site [active]
457570005011	putative NTP binding site [chemical binding]; other site
457570005012	putative nucleic acid binding site [nucleotide binding]; other site
457570005013	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570005014	elongation factor P; Validated; Region: PRK00529
457570005015	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
457570005016	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
457570005017	RNA binding site [nucleotide binding]; other site
457570005018	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
457570005019	RNA binding site [nucleotide binding]; other site
457570005020	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
457570005021	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
457570005022	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
457570005023	active site
457570005024	Dehydroquinase class II; Region: DHquinase_II; pfam01220
457570005025	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
457570005026	trimer interface [polypeptide binding]; other site
457570005027	active site
457570005028	dimer interface [polypeptide binding]; other site
457570005029	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
457570005030	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
457570005031	dimer interface [polypeptide binding]; other site
457570005032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570005033	catalytic residue [active]
457570005034	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
457570005035	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
457570005036	ADP binding site [chemical binding]; other site
457570005037	magnesium binding site [ion binding]; other site
457570005038	putative shikimate binding site; other site
457570005039	Late competence development protein ComFB; Region: ComFB; pfam10719
457570005040	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
457570005041	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
457570005042	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
457570005043	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
457570005044	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
457570005045	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
457570005046	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
457570005047	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
457570005048	Walker A motif; other site
457570005049	ATP binding site [chemical binding]; other site
457570005050	Walker B motif; other site
457570005051	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
457570005052	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
457570005053	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
457570005054	shikimate binding site; other site
457570005055	NAD(P) binding site [chemical binding]; other site
457570005056	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
457570005057	intracellular protease, PfpI family; Region: PfpI; TIGR01382
457570005058	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
457570005059	proposed catalytic triad [active]
457570005060	conserved cys residue [active]
457570005061	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
457570005062	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
457570005063	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
457570005064	active site
457570005065	motif I; other site
457570005066	motif II; other site
457570005067	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570005068	DNA binding residues [nucleotide binding]
457570005069	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
457570005070	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
457570005071	catalytic residues [active]
457570005072	catalytic nucleophile [active]
457570005073	Recombinase; Region: Recombinase; pfam07508
457570005074	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
457570005075	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
457570005076	catalytic triad [active]
457570005077	conserved cis-peptide bond; other site
457570005078	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
457570005079	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
457570005080	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
457570005081	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
457570005082	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
457570005083	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
457570005084	active site residues [active]
457570005085	dimer interface [polypeptide binding]; other site
457570005086	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
457570005087	EDD domain protein, DegV family; Region: DegV; TIGR00762
457570005088	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
457570005089	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
457570005090	tandem repeat interface [polypeptide binding]; other site
457570005091	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
457570005092	oligomer interface [polypeptide binding]; other site
457570005093	active site residues [active]
457570005094	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
457570005095	tandem repeat interface [polypeptide binding]; other site
457570005096	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
457570005097	oligomer interface [polypeptide binding]; other site
457570005098	active site residues [active]
457570005099	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570005100	FeS/SAM binding site; other site
457570005101	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
457570005102	Peptidase family M50; Region: Peptidase_M50; pfam02163
457570005103	active site
457570005104	putative substrate binding region [chemical binding]; other site
457570005105	FOG: CBS domain [General function prediction only]; Region: COG0517
457570005106	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
457570005107	Predicted amidohydrolase [General function prediction only]; Region: COG0388
457570005108	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
457570005109	active site
457570005110	catalytic triad [active]
457570005111	dimer interface [polypeptide binding]; other site
457570005112	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
457570005113	putative FMN binding site [chemical binding]; other site
457570005114	NADPH bind site [chemical binding]; other site
457570005115	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
457570005116	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
457570005117	Glutamate binding site [chemical binding]; other site
457570005118	NAD binding site [chemical binding]; other site
457570005119	catalytic residues [active]
457570005120	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
457570005121	hydroxyglutarate oxidase; Provisional; Region: PRK11728
457570005122	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
457570005123	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
457570005124	4Fe-4S binding domain; Region: Fer4; pfam00037
457570005125	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
457570005126	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
457570005127	Na binding site [ion binding]; other site
457570005128	CHD5-like protein; Region: CHD5; pfam04420
457570005129	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
457570005130	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
457570005131	Walker A/P-loop; other site
457570005132	ATP binding site [chemical binding]; other site
457570005133	Q-loop/lid; other site
457570005134	ABC transporter signature motif; other site
457570005135	Walker B; other site
457570005136	D-loop; other site
457570005137	H-loop/switch region; other site
457570005138	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
457570005139	thymidine kinase; Provisional; Region: PRK04296
457570005140	Asp23 family; Region: Asp23; pfam03780
457570005141	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
457570005142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
457570005143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
457570005144	Flagellar protein YcgR; Region: YcgR_2; pfam12945
457570005145	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
457570005146	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
457570005147	P-loop; other site
457570005148	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
457570005149	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
457570005150	Nucleoside recognition; Region: Gate; pfam07670
457570005151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570005152	Major Facilitator Superfamily; Region: MFS_1; pfam07690
457570005153	putative substrate translocation pore; other site
457570005154	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
457570005155	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570005156	FeS/SAM binding site; other site
457570005157	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
457570005158	Bacitracin resistance protein BacA; Region: BacA; cl00858
457570005159	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570005160	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
457570005161	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
457570005162	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
457570005163	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
457570005164	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
457570005165	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
457570005166	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
457570005167	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
457570005168	Peptidase family U32; Region: Peptidase_U32; pfam01136
457570005169	YceG-like family; Region: YceG; pfam02618
457570005170	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
457570005171	dimerization interface [polypeptide binding]; other site
457570005172	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
457570005173	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
457570005174	hypothetical protein; Provisional; Region: PRK05473
457570005175	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
457570005176	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
457570005177	motif 1; other site
457570005178	active site
457570005179	motif 2; other site
457570005180	motif 3; other site
457570005181	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
457570005182	DHHA1 domain; Region: DHHA1; pfam02272
457570005183	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
457570005184	Domain of unknown function DUF20; Region: UPF0118; pfam01594
457570005185	YtxH-like protein; Region: YtxH; cl02079
457570005186	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
457570005187	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
457570005188	Ligand Binding Site [chemical binding]; other site
457570005189	recombination factor protein RarA; Reviewed; Region: PRK13342
457570005190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570005191	Walker A motif; other site
457570005192	ATP binding site [chemical binding]; other site
457570005193	Walker B motif; other site
457570005194	arginine finger; other site
457570005195	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
457570005196	Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068
457570005197	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570005198	FeS/SAM binding site; other site
457570005199	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
457570005200	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
457570005201	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
457570005202	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
457570005203	Preprotein translocase subunit; Region: YajC; pfam02699
457570005204	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
457570005205	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
457570005206	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
457570005207	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
457570005208	Stage II sporulation protein; Region: SpoIID; pfam08486
457570005209	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
457570005210	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
457570005211	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
457570005212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570005213	Walker A motif; other site
457570005214	ATP binding site [chemical binding]; other site
457570005215	Walker B motif; other site
457570005216	arginine finger; other site
457570005217	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
457570005218	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
457570005219	RuvA N terminal domain; Region: RuvA_N; pfam01330
457570005220	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
457570005221	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
457570005222	active site
457570005223	putative DNA-binding cleft [nucleotide binding]; other site
457570005224	dimer interface [polypeptide binding]; other site
457570005225	hypothetical protein; Validated; Region: PRK00110
457570005226	NAD synthase; Region: NAD_synthase; pfam02540
457570005227	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
457570005228	homodimer interface [polypeptide binding]; other site
457570005229	NAD binding pocket [chemical binding]; other site
457570005230	ATP binding pocket [chemical binding]; other site
457570005231	Mg binding site [ion binding]; other site
457570005232	active-site loop [active]
457570005233	tyrosine phenol-lyase; Provisional; Region: PRK13237
457570005234	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
457570005235	substrate binding site [chemical binding]; other site
457570005236	tetramer interface [polypeptide binding]; other site
457570005237	catalytic residue [active]
457570005238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
457570005239	YheO-like PAS domain; Region: PAS_6; pfam08348
457570005240	HTH domain; Region: HTH_22; pfam13309
457570005241	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
457570005242	Amidohydrolase; Region: Amidohydro_2; pfam04909
457570005243	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
457570005244	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
457570005245	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
457570005246	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570005247	FeS/SAM binding site; other site
457570005248	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
457570005249	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
457570005250	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
457570005251	active site
457570005252	HIGH motif; other site
457570005253	dimer interface [polypeptide binding]; other site
457570005254	KMSKS motif; other site
457570005255	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
457570005256	RNA binding surface [nucleotide binding]; other site
457570005257	Transglycosylase; Region: Transgly; pfam00912
457570005258	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
457570005259	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
457570005260	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
457570005261	MutS domain III; Region: MutS_III; pfam05192
457570005262	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
457570005263	Walker A/P-loop; other site
457570005264	ATP binding site [chemical binding]; other site
457570005265	Q-loop/lid; other site
457570005266	ABC transporter signature motif; other site
457570005267	Walker B; other site
457570005268	D-loop; other site
457570005269	H-loop/switch region; other site
457570005270	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
457570005271	Smr domain; Region: Smr; pfam01713
457570005272	hypothetical protein; Provisional; Region: PRK08609
457570005273	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
457570005274	active site
457570005275	primer binding site [nucleotide binding]; other site
457570005276	NTP  binding site [chemical binding]; other site
457570005277	metal binding triad [ion binding]; metal-binding site
457570005278	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
457570005279	active site
457570005280	Cell division protein ZapA; Region: ZapA; cl01146
457570005281	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
457570005282	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
457570005283	putative tRNA-binding site [nucleotide binding]; other site
457570005284	B3/4 domain; Region: B3_4; pfam03483
457570005285	tRNA synthetase B5 domain; Region: B5; smart00874
457570005286	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
457570005287	dimer interface [polypeptide binding]; other site
457570005288	motif 1; other site
457570005289	motif 3; other site
457570005290	motif 2; other site
457570005291	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
457570005292	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
457570005293	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
457570005294	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
457570005295	dimer interface [polypeptide binding]; other site
457570005296	motif 1; other site
457570005297	active site
457570005298	motif 2; other site
457570005299	motif 3; other site
457570005300	T-box leader as predicted by Rfam (RF00230), score 105.59; T-box leader sequence
457570005301	YqzL-like protein; Region: YqzL; pfam14006
457570005302	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
457570005303	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
457570005304	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
457570005305	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570005306	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570005307	putative active site [active]
457570005308	putative NTP binding site [chemical binding]; other site
457570005309	putative nucleic acid binding site [nucleotide binding]; other site
457570005310	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570005311	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
457570005312	23S rRNA binding site [nucleotide binding]; other site
457570005313	L21 binding site [polypeptide binding]; other site
457570005314	L13 binding site [polypeptide binding]; other site
457570005315	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
457570005316	translation initiation factor IF-3; Region: infC; TIGR00168
457570005317	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
457570005318	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
457570005319	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
457570005320	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
457570005321	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
457570005322	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
457570005323	active site
457570005324	dimer interface [polypeptide binding]; other site
457570005325	motif 1; other site
457570005326	motif 2; other site
457570005327	motif 3; other site
457570005328	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
457570005329	anticodon binding site; other site
457570005330	T-box leader as predicted by Rfam (RF00230), score 74.48; T-box leader sequence
457570005331	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
457570005332	YtxC-like family; Region: YtxC; cl08500
457570005333	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
457570005334	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
457570005335	Isochorismatase family; Region: Isochorismatase; pfam00857
457570005336	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
457570005337	catalytic triad [active]
457570005338	conserved cis-peptide bond; other site
457570005339	Predicted transcriptional regulators [Transcription]; Region: COG1510
457570005340	MarR family; Region: MarR_2; pfam12802
457570005341	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
457570005342	thiS-thiF/thiG interaction site; other site
457570005343	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570005344	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570005345	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570005346	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
457570005347	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
457570005348	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
457570005349	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
457570005350	active site
457570005351	metal binding site [ion binding]; metal-binding site
457570005352	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
457570005353	GTP-binding protein YchF; Reviewed; Region: PRK09601
457570005354	YchF GTPase; Region: YchF; cd01900
457570005355	G1 box; other site
457570005356	GTP/Mg2+ binding site [chemical binding]; other site
457570005357	Switch I region; other site
457570005358	G2 box; other site
457570005359	Switch II region; other site
457570005360	G3 box; other site
457570005361	G4 box; other site
457570005362	G5 box; other site
457570005363	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
457570005364	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
457570005365	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570005366	H+ Antiporter protein; Region: 2A0121; TIGR00900
457570005367	putative substrate translocation pore; other site
457570005368	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
457570005369	dimerization interface [polypeptide binding]; other site
457570005370	putative DNA binding site [nucleotide binding]; other site
457570005371	putative Zn2+ binding site [ion binding]; other site
457570005372	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
457570005373	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
457570005374	active site 1 [active]
457570005375	active site 2 [active]
457570005376	PAS domain; Region: PAS_9; pfam13426
457570005377	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570005378	putative active site [active]
457570005379	heme pocket [chemical binding]; other site
457570005380	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
457570005381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
457570005382	dimer interface [polypeptide binding]; other site
457570005383	phosphorylation site [posttranslational modification]
457570005384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570005385	ATP binding site [chemical binding]; other site
457570005386	G-X-G motif; other site
457570005387	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
457570005388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570005389	active site
457570005390	phosphorylation site [posttranslational modification]
457570005391	intermolecular recognition site; other site
457570005392	dimerization interface [polypeptide binding]; other site
457570005393	PAS domain; Region: PAS_9; pfam13426
457570005394	PAS domain S-box; Region: sensory_box; TIGR00229
457570005395	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570005396	putative active site [active]
457570005397	heme pocket [chemical binding]; other site
457570005398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570005399	PAS fold; Region: PAS_3; pfam08447
457570005400	putative active site [active]
457570005401	heme pocket [chemical binding]; other site
457570005402	PAS domain S-box; Region: sensory_box; TIGR00229
457570005403	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570005404	putative active site [active]
457570005405	heme pocket [chemical binding]; other site
457570005406	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
457570005407	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
457570005408	Protein of unknown function DUF45; Region: DUF45; pfam01863
457570005409	aspartate aminotransferase; Provisional; Region: PRK05764
457570005410	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
457570005411	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570005412	homodimer interface [polypeptide binding]; other site
457570005413	catalytic residue [active]
457570005414	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
457570005415	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
457570005416	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
457570005417	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
457570005418	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570005419	Walker A motif; other site
457570005420	ATP binding site [chemical binding]; other site
457570005421	Walker B motif; other site
457570005422	arginine finger; other site
457570005423	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
457570005424	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
457570005425	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
457570005426	phosphate binding site [ion binding]; other site
457570005427	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
457570005428	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570005429	Dehydratase family; Region: ILVD_EDD; cl00340
457570005430	hypothetical protein; Provisional; Region: PRK07475
457570005431	D-glutamate deacylase; Validated; Region: PRK09061
457570005432	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570005433	active site
457570005434	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570005435	Predicted membrane protein [Function unknown]; Region: COG1288
457570005436	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
457570005437	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
457570005438	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
457570005439	metal binding site [ion binding]; metal-binding site
457570005440	dimer interface [polypeptide binding]; other site
457570005441	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
457570005442	Part of AAA domain; Region: AAA_19; pfam13245
457570005443	Family description; Region: UvrD_C_2; pfam13538
457570005444	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
457570005445	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
457570005446	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
457570005447	Acylphosphatase; Region: Acylphosphatase; pfam00708
457570005448	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570005449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570005450	Major Facilitator Superfamily; Region: MFS_1; pfam07690
457570005451	putative substrate translocation pore; other site
457570005452	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
457570005453	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
457570005454	amidase catalytic site [active]
457570005455	Zn binding residues [ion binding]; other site
457570005456	substrate binding site [chemical binding]; other site
457570005457	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570005458	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
457570005459	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
457570005460	CoA binding domain; Region: CoA_binding; pfam02629
457570005461	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
457570005462	Ferritin-like domain; Region: Ferritin; pfam00210
457570005463	dimanganese center [ion binding]; other site
457570005464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
457570005465	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
457570005466	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
457570005467	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
457570005468	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
457570005469	asparagine synthetase B; Provisional; Region: asnB; PRK09431
457570005470	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
457570005471	active site
457570005472	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
457570005473	Ligand Binding Site [chemical binding]; other site
457570005474	Molecular Tunnel; other site
457570005475	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
457570005476	Transporter associated domain; Region: CorC_HlyC; cl08393
457570005477	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
457570005478	metal-binding site [ion binding]
457570005479	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
457570005480	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
457570005481	metal-binding site [ion binding]
457570005482	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
457570005483	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
457570005484	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
457570005485	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
457570005486	putative active site [active]
457570005487	putative metal binding site [ion binding]; other site
457570005488	Domain of unknown function (DUF368); Region: DUF368; pfam04018
457570005489	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
457570005490	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
457570005491	active site
457570005492	substrate-binding site [chemical binding]; other site
457570005493	metal-binding site [ion binding]
457570005494	ATP binding site [chemical binding]; other site
457570005495	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
457570005496	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
457570005497	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
457570005498	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
457570005499	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
457570005500	substrate binding site [chemical binding]; other site
457570005501	oxyanion hole (OAH) forming residues; other site
457570005502	trimer interface [polypeptide binding]; other site
457570005503	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570005504	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570005505	putative active site [active]
457570005506	putative NTP binding site [chemical binding]; other site
457570005507	putative nucleic acid binding site [nucleotide binding]; other site
457570005508	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570005509	Ferredoxin [Energy production and conversion]; Region: COG1146
457570005510	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
457570005511	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
457570005512	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
457570005513	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
457570005514	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
457570005515	Ligand binding site [chemical binding]; other site
457570005516	Electron transfer flavoprotein domain; Region: ETF; pfam01012
457570005517	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
457570005518	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
457570005519	FAD binding site [chemical binding]; other site
457570005520	homotetramer interface [polypeptide binding]; other site
457570005521	substrate binding pocket [chemical binding]; other site
457570005522	catalytic base [active]
457570005523	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
457570005524	active site 2 [active]
457570005525	active site 1 [active]
457570005526	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
457570005527	NAD(P) binding site [chemical binding]; other site
457570005528	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
457570005529	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
457570005530	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
457570005531	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570005532	FeS/SAM binding site; other site
457570005533	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
457570005534	Cache domain; Region: Cache_1; pfam02743
457570005535	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
457570005536	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
457570005537	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570005538	dimer interface [polypeptide binding]; other site
457570005539	putative CheW interface [polypeptide binding]; other site
457570005540	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
457570005541	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
457570005542	N-acetyl-D-glucosamine binding site [chemical binding]; other site
457570005543	catalytic residue [active]
457570005544	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
457570005545	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
457570005546	CoA-binding site [chemical binding]; other site
457570005547	ATP-binding [chemical binding]; other site
457570005548	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
457570005549	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
457570005550	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
457570005551	DNA binding site [nucleotide binding]
457570005552	catalytic residue [active]
457570005553	H2TH interface [polypeptide binding]; other site
457570005554	putative catalytic residues [active]
457570005555	turnover-facilitating residue; other site
457570005556	intercalation triad [nucleotide binding]; other site
457570005557	8OG recognition residue [nucleotide binding]; other site
457570005558	putative reading head residues; other site
457570005559	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
457570005560	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
457570005561	DNA polymerase I; Provisional; Region: PRK05755
457570005562	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
457570005563	active site
457570005564	metal binding site 1 [ion binding]; metal-binding site
457570005565	putative 5' ssDNA interaction site; other site
457570005566	metal binding site 3; metal-binding site
457570005567	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
457570005568	putative DNA binding site [nucleotide binding]; other site
457570005569	putative metal binding site [ion binding]; other site
457570005570	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
457570005571	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
457570005572	active site
457570005573	DNA binding site [nucleotide binding]
457570005574	catalytic site [active]
457570005575	Putative zinc-finger; Region: zf-HC2; pfam13490
457570005576	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
457570005577	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570005578	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570005579	DNA binding residues [nucleotide binding]
457570005580	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
457570005581	peptidase T-like protein; Region: PepT-like; TIGR01883
457570005582	metal binding site [ion binding]; metal-binding site
457570005583	putative dimer interface [polypeptide binding]; other site
457570005584	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
457570005585	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
457570005586	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
457570005587	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
457570005588	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
457570005589	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
457570005590	histidinol dehydrogenase; Region: hisD; TIGR00069
457570005591	NAD binding site [chemical binding]; other site
457570005592	dimerization interface [polypeptide binding]; other site
457570005593	product binding site; other site
457570005594	substrate binding site [chemical binding]; other site
457570005595	zinc binding site [ion binding]; other site
457570005596	catalytic residues [active]
457570005597	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
457570005598	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570005599	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570005600	putative active site [active]
457570005601	putative NTP binding site [chemical binding]; other site
457570005602	putative nucleic acid binding site [nucleotide binding]; other site
457570005603	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570005604	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188
457570005605	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
457570005606	NAD(P) binding site [chemical binding]; other site
457570005607	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
457570005608	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
457570005609	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
457570005610	active site
457570005611	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
457570005612	B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067
457570005613	B12 binding site [chemical binding]; other site
457570005614	cobalt ligand [ion binding]; other site
457570005615	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
457570005616	putative acyltransferase; Provisional; Region: PRK05790
457570005617	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
457570005618	dimer interface [polypeptide binding]; other site
457570005619	active site
457570005620	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
457570005621	Coenzyme A transferase; Region: CoA_trans; cl17247
457570005622	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
457570005623	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570005624	putative active site [active]
457570005625	heme pocket [chemical binding]; other site
457570005626	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570005627	putative active site [active]
457570005628	heme pocket [chemical binding]; other site
457570005629	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570005630	Walker A motif; other site
457570005631	ATP binding site [chemical binding]; other site
457570005632	Walker B motif; other site
457570005633	arginine finger; other site
457570005634	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
457570005635	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570005636	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570005637	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570005638	Integrase core domain; Region: rve; pfam00665
457570005639	Integrase core domain; Region: rve_3; cl15866
457570005640	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
457570005641	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
457570005642	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
457570005643	diaminopimelate decarboxylase; Region: lysA; TIGR01048
457570005644	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
457570005645	active site
457570005646	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
457570005647	substrate binding site [chemical binding]; other site
457570005648	catalytic residues [active]
457570005649	dimer interface [polypeptide binding]; other site
457570005650	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
457570005651	thiS-thiF/thiG interaction site; other site
457570005652	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
457570005653	ThiS interaction site; other site
457570005654	putative active site [active]
457570005655	tetramer interface [polypeptide binding]; other site
457570005656	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
457570005657	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570005658	FeS/SAM binding site; other site
457570005659	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
457570005660	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
457570005661	thiamine phosphate binding site [chemical binding]; other site
457570005662	active site
457570005663	pyrophosphate binding site [ion binding]; other site
457570005664	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
457570005665	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
457570005666	putative [4Fe-4S] binding site [ion binding]; other site
457570005667	putative molybdopterin cofactor binding site [chemical binding]; other site
457570005668	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
457570005669	molybdopterin cofactor binding site; other site
457570005670	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570005671	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570005672	putative active site [active]
457570005673	putative NTP binding site [chemical binding]; other site
457570005674	putative nucleic acid binding site [nucleotide binding]; other site
457570005675	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570005676	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570005677	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570005678	putative active site [active]
457570005679	putative NTP binding site [chemical binding]; other site
457570005680	putative nucleic acid binding site [nucleotide binding]; other site
457570005681	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570005682	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
457570005683	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570005684	active site
457570005685	phosphorylation site [posttranslational modification]
457570005686	intermolecular recognition site; other site
457570005687	dimerization interface [polypeptide binding]; other site
457570005688	LytTr DNA-binding domain; Region: LytTR; smart00850
457570005689	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570005690	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570005691	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
457570005692	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570005693	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570005694	helix-hairpin-helix signature motif; other site
457570005695	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
457570005696	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
457570005697	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
457570005698	Zn binding sites [ion binding]; other site
457570005699	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
457570005700	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
457570005701	Zn binding sites [ion binding]; other site
457570005702	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
457570005703	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
457570005704	Zn binding sites [ion binding]; other site
457570005705	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
457570005706	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
457570005707	Walker A/P-loop; other site
457570005708	ATP binding site [chemical binding]; other site
457570005709	Q-loop/lid; other site
457570005710	ABC transporter signature motif; other site
457570005711	Walker B; other site
457570005712	D-loop; other site
457570005713	H-loop/switch region; other site
457570005714	Cobalt transport protein; Region: CbiQ; cl00463
457570005715	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
457570005716	cobalt transport protein CbiM; Validated; Region: PRK06265
457570005717	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
457570005718	metal binding site 2 [ion binding]; metal-binding site
457570005719	putative DNA binding helix; other site
457570005720	metal binding site 1 [ion binding]; metal-binding site
457570005721	dimer interface [polypeptide binding]; other site
457570005722	structural Zn2+ binding site [ion binding]; other site
457570005723	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
457570005724	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
457570005725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570005726	homodimer interface [polypeptide binding]; other site
457570005727	catalytic residue [active]
457570005728	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
457570005729	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
457570005730	PYR/PP interface [polypeptide binding]; other site
457570005731	dimer interface [polypeptide binding]; other site
457570005732	TPP binding site [chemical binding]; other site
457570005733	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
457570005734	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
457570005735	TPP-binding site [chemical binding]; other site
457570005736	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
457570005737	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
457570005738	dimer interface [polypeptide binding]; other site
457570005739	active site
457570005740	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
457570005741	substrate binding site [chemical binding]; other site
457570005742	catalytic residue [active]
457570005743	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
457570005744	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
457570005745	active site
457570005746	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
457570005747	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
457570005748	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
457570005749	Protein export membrane protein; Region: SecD_SecF; cl14618
457570005750	HlyD family secretion protein; Region: HlyD_2; pfam12700
457570005751	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
457570005752	HlyD family secretion protein; Region: HlyD_3; pfam13437
457570005753	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
457570005754	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
457570005755	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
457570005756	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
457570005757	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
457570005758	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
457570005759	HlyD family secretion protein; Region: HlyD_3; pfam13437
457570005760	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570005761	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570005762	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570005763	Integrase core domain; Region: rve; pfam00665
457570005764	Integrase core domain; Region: rve_3; cl15866
457570005765	Outer membrane efflux protein; Region: OEP; pfam02321
457570005766	amidase; Provisional; Region: PRK06828
457570005767	Amidase; Region: Amidase; pfam01425
457570005768	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
457570005769	dimer interface [polypeptide binding]; other site
457570005770	pyridoxal binding site [chemical binding]; other site
457570005771	ATP binding site [chemical binding]; other site
457570005772	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
457570005773	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
457570005774	active site
457570005775	metal binding site [ion binding]; metal-binding site
457570005776	homotetramer interface [polypeptide binding]; other site
457570005777	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
457570005778	active site
457570005779	dimerization interface [polypeptide binding]; other site
457570005780	ribonuclease PH; Reviewed; Region: rph; PRK00173
457570005781	Ribonuclease PH; Region: RNase_PH_bact; cd11362
457570005782	hexamer interface [polypeptide binding]; other site
457570005783	active site
457570005784	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
457570005785	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
457570005786	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
457570005787	Cl- selectivity filter; other site
457570005788	Cl- binding residues [ion binding]; other site
457570005789	pore gating glutamate residue; other site
457570005790	dimer interface [polypeptide binding]; other site
457570005791	Sporulation and spore germination; Region: Germane; pfam10646
457570005792	Sporulation and spore germination; Region: Germane; pfam10646
457570005793	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025
457570005794	B12 cofactor binding site [chemical binding]; other site
457570005795	substrate binding site [chemical binding]; other site
457570005796	heterodimer (sigma-epsilon) interface [polypeptide binding]; other site
457570005797	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
457570005798	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
457570005799	MarR family; Region: MarR; pfam01047
457570005800	Protein of unknown function (DUF441); Region: DUF441; pfam04284
457570005801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
457570005802	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
457570005803	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
457570005804	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
457570005805	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
457570005806	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
457570005807	Coat F domain; Region: Coat_F; pfam07875
457570005808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
457570005809	Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031
457570005810	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
457570005811	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
457570005812	Uncharacterized conserved protein [Function unknown]; Region: COG3461
457570005813	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
457570005814	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
457570005815	trimer interface [polypeptide binding]; other site
457570005816	active site
457570005817	YGGT family; Region: YGGT; pfam02325
457570005818	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
457570005819	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
457570005820	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
457570005821	Response regulator receiver domain; Region: Response_reg; pfam00072
457570005822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570005823	active site
457570005824	phosphorylation site [posttranslational modification]
457570005825	intermolecular recognition site; other site
457570005826	dimerization interface [polypeptide binding]; other site
457570005827	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570005828	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570005829	metal binding site [ion binding]; metal-binding site
457570005830	active site
457570005831	I-site; other site
457570005832	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
457570005833	Uncharacterized protein conserved in bacteria (DUF2321); Region: DUF2321; pfam10083
457570005834	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570005835	Transposase; Region: HTH_Tnp_1; pfam01527
457570005836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
457570005837	AAA domain; Region: AAA_22; pfam13401
457570005838	Walker A motif; other site
457570005839	ATP binding site [chemical binding]; other site
457570005840	Walker B motif; other site
457570005841	arginine finger; other site
457570005842	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
457570005843	Integrase core domain; Region: rve; pfam00665
457570005844	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570005845	Transposase; Region: HTH_Tnp_1; pfam01527
457570005846	EVE domain; Region: EVE; cl00728
457570005847	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
457570005848	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
457570005849	HsdM N-terminal domain; Region: HsdM_N; pfam12161
457570005850	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
457570005851	Methyltransferase domain; Region: Methyltransf_26; pfam13659
457570005852	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
457570005853	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
457570005854	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
457570005855	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
457570005856	ATP binding site [chemical binding]; other site
457570005857	putative Mg++ binding site [ion binding]; other site
457570005858	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
457570005859	SmpB-tmRNA interface; other site
457570005860	histidinol-phosphatase; Provisional; Region: PRK07328
457570005861	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
457570005862	active site
457570005863	dimer interface [polypeptide binding]; other site
457570005864	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
457570005865	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
457570005866	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
457570005867	metal binding site [ion binding]; metal-binding site
457570005868	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
457570005869	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
457570005870	substrate binding site [chemical binding]; other site
457570005871	glutamase interaction surface [polypeptide binding]; other site
457570005872	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
457570005873	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
457570005874	catalytic residues [active]
457570005875	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
457570005876	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
457570005877	putative active site [active]
457570005878	oxyanion strand; other site
457570005879	catalytic triad [active]
457570005880	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
457570005881	putative active site pocket [active]
457570005882	4-fold oligomerization interface [polypeptide binding]; other site
457570005883	metal binding residues [ion binding]; metal-binding site
457570005884	3-fold/trimer interface [polypeptide binding]; other site
457570005885	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
457570005886	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
457570005887	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
457570005888	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
457570005889	dimer interface [polypeptide binding]; other site
457570005890	motif 1; other site
457570005891	active site
457570005892	motif 2; other site
457570005893	motif 3; other site
457570005894	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
457570005895	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
457570005896	active site
457570005897	dimer interface [polypeptide binding]; other site
457570005898	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
457570005899	dimer interface [polypeptide binding]; other site
457570005900	active site
457570005901	6-phosphofructokinase; Provisional; Region: PRK03202
457570005902	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
457570005903	active site
457570005904	ADP/pyrophosphate binding site [chemical binding]; other site
457570005905	dimerization interface [polypeptide binding]; other site
457570005906	allosteric effector site; other site
457570005907	fructose-1,6-bisphosphate binding site; other site
457570005908	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
457570005909	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
457570005910	FMN-binding domain; Region: FMN_bind; cl01081
457570005911	FMN-binding domain; Region: FMN_bind; cl01081
457570005912	FMN-binding domain; Region: FMN_bind; pfam04205
457570005913	FMN-binding domain; Region: FMN_bind; pfam04205
457570005914	FMN-binding domain; Region: FMN_bind; cl01081
457570005915	ribonuclease R; Region: RNase_R; TIGR02063
457570005916	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
457570005917	RNB domain; Region: RNB; pfam00773
457570005918	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
457570005919	RNA binding site [nucleotide binding]; other site
457570005920	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570005921	Zn2+ binding site [ion binding]; other site
457570005922	Mg2+ binding site [ion binding]; other site
457570005923	Esterase/lipase [General function prediction only]; Region: COG1647
457570005924	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
457570005925	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
457570005926	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
457570005927	enolase; Provisional; Region: eno; PRK00077
457570005928	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
457570005929	dimer interface [polypeptide binding]; other site
457570005930	metal binding site [ion binding]; metal-binding site
457570005931	substrate binding pocket [chemical binding]; other site
457570005932	phosphoglyceromutase; Provisional; Region: PRK05434
457570005933	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
457570005934	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
457570005935	triosephosphate isomerase; Provisional; Region: PRK14565
457570005936	substrate binding site [chemical binding]; other site
457570005937	dimer interface [polypeptide binding]; other site
457570005938	catalytic triad [active]
457570005939	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
457570005940	Phosphoglycerate kinase; Region: PGK; pfam00162
457570005941	substrate binding site [chemical binding]; other site
457570005942	hinge regions; other site
457570005943	ADP binding site [chemical binding]; other site
457570005944	catalytic site [active]
457570005945	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
457570005946	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
457570005947	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
457570005948	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
457570005949	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
457570005950	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
457570005951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
457570005952	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
457570005953	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
457570005954	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
457570005955	substrate binding site [chemical binding]; other site
457570005956	tetramer interface [polypeptide binding]; other site
457570005957	catalytic residue [active]
457570005958	YtpI-like protein; Region: YtpI; pfam14007
457570005959	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
457570005960	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
457570005961	phosphate binding site [ion binding]; other site
457570005962	putative substrate binding pocket [chemical binding]; other site
457570005963	dimer interface [polypeptide binding]; other site
457570005964	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
457570005965	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
457570005966	Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387
457570005967	active site
457570005968	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
457570005969	metal ion-dependent adhesion site (MIDAS); other site
457570005970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570005971	Walker A motif; other site
457570005972	ATP binding site [chemical binding]; other site
457570005973	Walker B motif; other site
457570005974	arginine finger; other site
457570005975	putative hydrolase; Validated; Region: PRK09248
457570005976	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
457570005977	active site
457570005978	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
457570005979	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
457570005980	dimerization interface [polypeptide binding]; other site
457570005981	ligand binding site [chemical binding]; other site
457570005982	NADP binding site [chemical binding]; other site
457570005983	catalytic site [active]
457570005984	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
457570005985	trimer interface [polypeptide binding]; other site
457570005986	putative Zn binding site [ion binding]; other site
457570005987	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
457570005988	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
457570005989	active site
457570005990	FMN binding site [chemical binding]; other site
457570005991	substrate binding site [chemical binding]; other site
457570005992	putative catalytic residues [active]
457570005993	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
457570005994	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
457570005995	active site
457570005996	motif I; other site
457570005997	motif II; other site
457570005998	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
457570005999	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
457570006000	Transglycosylase; Region: Transgly; pfam00912
457570006001	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
457570006002	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
457570006003	ligand binding site [chemical binding]; other site
457570006004	flexible hinge region; other site
457570006005	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
457570006006	non-specific DNA interactions [nucleotide binding]; other site
457570006007	DNA binding site [nucleotide binding]
457570006008	sequence specific DNA binding site [nucleotide binding]; other site
457570006009	putative cAMP binding site [chemical binding]; other site
457570006010	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
457570006011	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
457570006012	GIY-YIG motif/motif A; other site
457570006013	active site
457570006014	catalytic site [active]
457570006015	putative DNA binding site [nucleotide binding]; other site
457570006016	metal binding site [ion binding]; metal-binding site
457570006017	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
457570006018	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
457570006019	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
457570006020	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
457570006021	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
457570006022	excinuclease ABC subunit B; Provisional; Region: PRK05298
457570006023	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
457570006024	ATP binding site [chemical binding]; other site
457570006025	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
457570006026	nucleotide binding region [chemical binding]; other site
457570006027	ATP-binding site [chemical binding]; other site
457570006028	Ultra-violet resistance protein B; Region: UvrB; pfam12344
457570006029	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
457570006030	Tetratricopeptide repeat; Region: TPR_12; pfam13424
457570006031	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
457570006032	binding surface
457570006033	TPR motif; other site
457570006034	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
457570006035	Bifunctional nuclease; Region: DNase-RNase; pfam02577
457570006036	SurA N-terminal domain; Region: SurA_N; pfam09312
457570006037	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
457570006038	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
457570006039	Walker A/P-loop; other site
457570006040	ATP binding site [chemical binding]; other site
457570006041	Q-loop/lid; other site
457570006042	ABC transporter signature motif; other site
457570006043	Walker B; other site
457570006044	D-loop; other site
457570006045	H-loop/switch region; other site
457570006046	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
457570006047	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
457570006048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570006049	dimer interface [polypeptide binding]; other site
457570006050	conserved gate region; other site
457570006051	ABC-ATPase subunit interface; other site
457570006052	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
457570006053	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
457570006054	T-box leader as predicted by Rfam (RF00230), score 87.62; T-box leader sequence
457570006055	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
457570006056	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
457570006057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570006058	homodimer interface [polypeptide binding]; other site
457570006059	catalytic residue [active]
457570006060	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
457570006061	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
457570006062	prephenate dehydrogenase; Validated; Region: PRK08507
457570006063	prephenate dehydrogenase; Validated; Region: PRK06545
457570006064	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
457570006065	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
457570006066	hinge; other site
457570006067	active site
457570006068	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
457570006069	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
457570006070	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
457570006071	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
457570006072	active site
457570006073	NAD binding site [chemical binding]; other site
457570006074	metal binding site [ion binding]; metal-binding site
457570006075	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
457570006076	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
457570006077	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
457570006078	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
457570006079	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570006080	Predicted transcriptional regulators [Transcription]; Region: COG1510
457570006081	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570006082	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570006083	Zn2+ binding site [ion binding]; other site
457570006084	Mg2+ binding site [ion binding]; other site
457570006085	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570006086	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
457570006087	active site
457570006088	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
457570006089	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570006090	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570006091	DNA binding residues [nucleotide binding]
457570006092	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
457570006093	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
457570006094	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
457570006095	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
457570006096	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
457570006097	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
457570006098	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
457570006099	NodB motif; other site
457570006100	active site
457570006101	catalytic site [active]
457570006102	metal binding site [ion binding]; metal-binding site
457570006103	hypothetical protein; Provisional; Region: PRK04164
457570006104	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
457570006105	threonine synthase; Validated; Region: PRK06450
457570006106	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
457570006107	homodimer interface [polypeptide binding]; other site
457570006108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570006109	catalytic residue [active]
457570006110	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570006111	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570006112	putative active site [active]
457570006113	putative NTP binding site [chemical binding]; other site
457570006114	putative nucleic acid binding site [nucleotide binding]; other site
457570006115	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570006116	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
457570006117	Transglycosylase; Region: Transgly; pfam00912
457570006118	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
457570006119	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
457570006120	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
457570006121	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
457570006122	putative substrate binding pocket [chemical binding]; other site
457570006123	AC domain interface; other site
457570006124	catalytic triad [active]
457570006125	AB domain interface; other site
457570006126	interchain disulfide; other site
457570006127	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
457570006128	active site
457570006129	catalytic residues [active]
457570006130	DNA binding site [nucleotide binding]
457570006131	Int/Topo IB signature motif; other site
457570006132	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570006133	D-galactonate transporter; Region: 2A0114; TIGR00893
457570006134	putative substrate translocation pore; other site
457570006135	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
457570006136	HD domain; Region: HD_3; pfam13023
457570006137	BON domain; Region: BON; pfam04972
457570006138	BON domain; Region: BON; pfam04972
457570006139	BON domain; Region: BON; pfam04972
457570006140	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570006141	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570006142	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570006143	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
457570006144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570006145	active site
457570006146	phosphorylation site [posttranslational modification]
457570006147	intermolecular recognition site; other site
457570006148	dimerization interface [polypeptide binding]; other site
457570006149	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
457570006150	DNA binding residues [nucleotide binding]
457570006151	dimerization interface [polypeptide binding]; other site
457570006152	HAMP domain; Region: HAMP; pfam00672
457570006153	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
457570006154	Histidine kinase; Region: HisKA_3; pfam07730
457570006155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570006156	ATP binding site [chemical binding]; other site
457570006157	Mg2+ binding site [ion binding]; other site
457570006158	G-X-G motif; other site
457570006159	Predicted membrane protein [Function unknown]; Region: COG4758
457570006160	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
457570006161	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
457570006162	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
457570006163	HlyD family secretion protein; Region: HlyD_3; pfam13437
457570006164	FtsX-like permease family; Region: FtsX; pfam02687
457570006165	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
457570006166	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
457570006167	FtsX-like permease family; Region: FtsX; pfam02687
457570006168	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
457570006169	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
457570006170	Walker A/P-loop; other site
457570006171	ATP binding site [chemical binding]; other site
457570006172	Q-loop/lid; other site
457570006173	ABC transporter signature motif; other site
457570006174	Walker B; other site
457570006175	D-loop; other site
457570006176	H-loop/switch region; other site
457570006177	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
457570006178	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
457570006179	Virus attachment protein p12 family; Region: P12; pfam12669
457570006180	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
457570006181	Ferritin-like domain; Region: Ferritin; pfam00210
457570006182	heme binding site [chemical binding]; other site
457570006183	ferroxidase pore; other site
457570006184	ferroxidase diiron center [ion binding]; other site
457570006185	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
457570006186	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
457570006187	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
457570006188	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
457570006189	Uncharacterized conserved protein [Function unknown]; Region: COG2014
457570006190	Domain of unknown function (DUF364); Region: DUF364; pfam04016
457570006191	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570006192	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
457570006193	Competence protein A; Region: Competence_A; pfam11104
457570006194	Cell division protein FtsA; Region: FtsA; pfam14450
457570006195	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
457570006196	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
457570006197	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
457570006198	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
457570006199	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
457570006200	Walker A motif; other site
457570006201	ATP binding site [chemical binding]; other site
457570006202	Walker B motif; other site
457570006203	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
457570006204	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
457570006205	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
457570006206	Walker A motif; other site
457570006207	ATP binding site [chemical binding]; other site
457570006208	Walker B motif; other site
457570006209	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
457570006210	Protein of unknown function DUF58; Region: DUF58; pfam01882
457570006211	MoxR-like ATPases [General function prediction only]; Region: COG0714
457570006212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570006213	Walker A motif; other site
457570006214	ATP binding site [chemical binding]; other site
457570006215	Walker B motif; other site
457570006216	arginine finger; other site
457570006217	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
457570006218	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
457570006219	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
457570006220	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
457570006221	intersubunit interface [polypeptide binding]; other site
457570006222	active site
457570006223	Zn2+ binding site [ion binding]; other site
457570006224	Sensory domain found in PocR; Region: PocR; pfam10114
457570006225	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
457570006226	PAS fold; Region: PAS; pfam00989
457570006227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570006228	putative active site [active]
457570006229	heme pocket [chemical binding]; other site
457570006230	PAS domain S-box; Region: sensory_box; TIGR00229
457570006231	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570006232	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570006233	metal binding site [ion binding]; metal-binding site
457570006234	active site
457570006235	I-site; other site
457570006236	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570006237	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570006238	Zn2+ binding site [ion binding]; other site
457570006239	Mg2+ binding site [ion binding]; other site
457570006240	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
457570006241	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
457570006242	Peptidase family M28; Region: Peptidase_M28; pfam04389
457570006243	metal binding site [ion binding]; metal-binding site
457570006244	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_7; cd06244
457570006245	putative active site [active]
457570006246	Zn binding site [ion binding]; other site
457570006247	Uncharacterized conserved protein [Function unknown]; Region: COG3334
457570006248	Predicted membrane protein [Function unknown]; Region: COG2311
457570006249	Protein of unknown function (DUF418); Region: DUF418; pfam04235
457570006250	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
457570006251	active site
457570006252	catalytic site [active]
457570006253	FMN-binding domain; Region: FMN_bind; cl01081
457570006254	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
457570006255	DNA methylase; Region: N6_N4_Mtase; pfam01555
457570006256	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570006257	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
457570006258	Peptidase family M23; Region: Peptidase_M23; pfam01551
457570006259	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570006260	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
457570006261	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
457570006262	Minimal MMP-like domain found in Thermus thermophilus hypothetical protein TTHA0227 and similar proteins; Region: MMP_TTHA0227; cd12953
457570006263	Uncharacterized conserved protein [Function unknown]; Region: COG1683
457570006264	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570006265	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570006266	Zn2+ binding site [ion binding]; other site
457570006267	Mg2+ binding site [ion binding]; other site
457570006268	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
457570006269	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
457570006270	putative FMN binding site [chemical binding]; other site
457570006271	Cation efflux family; Region: Cation_efflux; cl00316
457570006272	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
457570006273	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
457570006274	Putative motility protein; Region: YjfB_motility; pfam14070
457570006275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570006276	Transposase; Region: HTH_Tnp_1; pfam01527
457570006277	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
457570006278	hypothetical protein; Provisional; Region: PRK00955
457570006279	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
457570006280	peroxiredoxin; Provisional; Region: PRK13189
457570006281	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
457570006282	dimer interface [polypeptide binding]; other site
457570006283	decamer (pentamer of dimers) interface [polypeptide binding]; other site
457570006284	catalytic triad [active]
457570006285	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
457570006286	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
457570006287	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
457570006288	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
457570006289	Catalytic site [active]
457570006290	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
457570006291	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570006292	FeS/SAM binding site; other site
457570006293	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
457570006294	Part of AAA domain; Region: AAA_19; pfam13245
457570006295	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
457570006296	active site
457570006297	catalytic site [active]
457570006298	substrate binding site [chemical binding]; other site
457570006299	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
457570006300	Family description; Region: UvrD_C_2; pfam13538
457570006301	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
457570006302	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570006303	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570006304	Zn2+ binding site [ion binding]; other site
457570006305	Mg2+ binding site [ion binding]; other site
457570006306	photolyase PhrII; Region: phr2; TIGR00591
457570006307	DNA photolyase; Region: DNA_photolyase; pfam00875
457570006308	Uncharacterized conserved protein [Function unknown]; Region: COG1683
457570006309	Uncharacterized conserved protein [Function unknown]; Region: COG3272
457570006310	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
457570006311	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
457570006312	MutS domain III; Region: MutS_III; cl17822
457570006313	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
457570006314	Walker A/P-loop; other site
457570006315	ATP binding site [chemical binding]; other site
457570006316	Q-loop/lid; other site
457570006317	ABC transporter signature motif; other site
457570006318	Walker B; other site
457570006319	D-loop; other site
457570006320	H-loop/switch region; other site
457570006321	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
457570006322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570006323	active site
457570006324	phosphorylation site [posttranslational modification]
457570006325	intermolecular recognition site; other site
457570006326	dimerization interface [polypeptide binding]; other site
457570006327	LytTr DNA-binding domain; Region: LytTR; pfam04397
457570006328	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
457570006329	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
457570006330	active site
457570006331	catalytic residues [active]
457570006332	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
457570006333	Amidohydrolase; Region: Amidohydro_5; pfam13594
457570006334	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
457570006335	active site
457570006336	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570006337	Amino acid synthesis; Region: AA_synth; pfam06684
457570006338	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570006339	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570006340	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570006341	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570006342	hypothetical protein; Provisional; Region: PRK04334
457570006343	4Fe-4S binding domain; Region: Fer4; pfam00037
457570006344	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
457570006345	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
457570006346	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
457570006347	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
457570006348	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
457570006349	Amidase; Region: Amidase; cl11426
457570006350	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
457570006351	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
457570006352	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
457570006353	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
457570006354	FAD binding domain; Region: FAD_binding_4; pfam01565
457570006355	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
457570006356	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
457570006357	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
457570006358	tetramer interface [polypeptide binding]; other site
457570006359	active site
457570006360	Mg2+/Mn2+ binding site [ion binding]; other site
457570006361	MutL protein; Region: MutL; pfam13941
457570006362	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
457570006363	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025
457570006364	B12 cofactor binding site [chemical binding]; other site
457570006365	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
457570006366	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
457570006367	B12 binding site [chemical binding]; other site
457570006368	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
457570006369	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
457570006370	substrate binding site [chemical binding]; other site
457570006371	3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Region: LeuC; COG0065
457570006372	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
457570006373	substrate binding site [chemical binding]; other site
457570006374	ligand binding site [chemical binding]; other site
457570006375	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
457570006376	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
457570006377	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
457570006378	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
457570006379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570006380	Walker A motif; other site
457570006381	ATP binding site [chemical binding]; other site
457570006382	Walker B motif; other site
457570006383	arginine finger; other site
457570006384	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
457570006385	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
457570006386	Na binding site [ion binding]; other site
457570006387	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
457570006388	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
457570006389	conserved cys residue [active]
457570006390	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
457570006391	Ferritin-like domain; Region: Ferritin; pfam00210
457570006392	dinuclear metal binding motif [ion binding]; other site
457570006393	Uncharacterized conserved protein [Function unknown]; Region: COG1434
457570006394	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
457570006395	putative active site [active]
457570006396	Methyltransferase domain; Region: Methyltransf_31; pfam13847
457570006397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570006398	S-adenosylmethionine binding site [chemical binding]; other site
457570006399	Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050
457570006400	Predicted GTPase [General function prediction only]; Region: DRG; COG1163
457570006401	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
457570006402	G1 box; other site
457570006403	GTP/Mg2+ binding site [chemical binding]; other site
457570006404	G2 box; other site
457570006405	Switch I region; other site
457570006406	G3 box; other site
457570006407	Switch II region; other site
457570006408	TGS_DRG_C:   DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...; Region: TGS_DRG_C; cd01666
457570006409	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
457570006410	putative deacylase active site [active]
457570006411	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
457570006412	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
457570006413	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
457570006414	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
457570006415	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
457570006416	metal binding site [ion binding]; metal-binding site
457570006417	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
457570006418	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570006419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570006420	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570006421	Integrase core domain; Region: rve; pfam00665
457570006422	Integrase core domain; Region: rve_3; cl15866
457570006423	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
457570006424	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
457570006425	E3 interaction surface; other site
457570006426	lipoyl attachment site [posttranslational modification]; other site
457570006427	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
457570006428	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
457570006429	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570006430	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
457570006431	FOG: CBS domain [General function prediction only]; Region: COG0517
457570006432	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
457570006433	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
457570006434	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570006435	Walker A motif; other site
457570006436	ATP binding site [chemical binding]; other site
457570006437	Walker B motif; other site
457570006438	arginine finger; other site
457570006439	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
457570006440	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
457570006441	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570006442	dimer interface [polypeptide binding]; other site
457570006443	putative CheW interface [polypeptide binding]; other site
457570006444	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570006445	Bacterial SH3 domain; Region: SH3_3; pfam08239
457570006446	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
457570006447	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
457570006448	active site
457570006449	metal binding site [ion binding]; metal-binding site
457570006450	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
457570006451	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
457570006452	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
457570006453	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570006454	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570006455	putative active site [active]
457570006456	putative NTP binding site [chemical binding]; other site
457570006457	putative nucleic acid binding site [nucleotide binding]; other site
457570006458	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570006459	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
457570006460	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570006461	dimer interface [polypeptide binding]; other site
457570006462	putative CheW interface [polypeptide binding]; other site
457570006463	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570006464	PAS domain; Region: PAS_9; pfam13426
457570006465	putative active site [active]
457570006466	heme pocket [chemical binding]; other site
457570006467	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570006468	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570006469	metal binding site [ion binding]; metal-binding site
457570006470	active site
457570006471	I-site; other site
457570006472	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570006473	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570006474	Zn2+ binding site [ion binding]; other site
457570006475	Mg2+ binding site [ion binding]; other site
457570006476	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
457570006477	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
457570006478	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
457570006479	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
457570006480	C-terminal peptidase (prc); Region: prc; TIGR00225
457570006481	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
457570006482	protein binding site [polypeptide binding]; other site
457570006483	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
457570006484	Catalytic dyad [active]
457570006485	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
457570006486	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
457570006487	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
457570006488	Peptidase family M23; Region: Peptidase_M23; pfam01551
457570006489	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
457570006490	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
457570006491	FtsX-like permease family; Region: FtsX; pfam02687
457570006492	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
457570006493	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570006494	Walker A/P-loop; other site
457570006495	ATP binding site [chemical binding]; other site
457570006496	Q-loop/lid; other site
457570006497	ABC transporter signature motif; other site
457570006498	Walker B; other site
457570006499	D-loop; other site
457570006500	H-loop/switch region; other site
457570006501	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
457570006502	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570006503	dimer interface [polypeptide binding]; other site
457570006504	conserved gate region; other site
457570006505	putative PBP binding loops; other site
457570006506	ABC-ATPase subunit interface; other site
457570006507	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
457570006508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570006509	dimer interface [polypeptide binding]; other site
457570006510	conserved gate region; other site
457570006511	putative PBP binding loops; other site
457570006512	ABC-ATPase subunit interface; other site
457570006513	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
457570006514	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570006515	Walker A/P-loop; other site
457570006516	ATP binding site [chemical binding]; other site
457570006517	Q-loop/lid; other site
457570006518	ABC transporter signature motif; other site
457570006519	Walker B; other site
457570006520	D-loop; other site
457570006521	H-loop/switch region; other site
457570006522	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570006523	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570006524	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
457570006525	Walker A/P-loop; other site
457570006526	ATP binding site [chemical binding]; other site
457570006527	Q-loop/lid; other site
457570006528	ABC transporter signature motif; other site
457570006529	Walker B; other site
457570006530	D-loop; other site
457570006531	H-loop/switch region; other site
457570006532	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570006533	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570006534	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
457570006535	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570006536	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
457570006537	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
457570006538	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570006539	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570006540	metal binding site [ion binding]; metal-binding site
457570006541	active site
457570006542	I-site; other site
457570006543	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570006544	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570006545	Zn2+ binding site [ion binding]; other site
457570006546	Mg2+ binding site [ion binding]; other site
457570006547	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
457570006548	Ligand binding site; other site
457570006549	metal-binding site
457570006550	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
457570006551	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
457570006552	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570006553	putative PBP binding loops; other site
457570006554	dimer interface [polypeptide binding]; other site
457570006555	ABC-ATPase subunit interface; other site
457570006556	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
457570006557	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
457570006558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
457570006559	Walker A/P-loop; other site
457570006560	ATP binding site [chemical binding]; other site
457570006561	ABC transporter; Region: ABC_tran; pfam00005
457570006562	Q-loop/lid; other site
457570006563	ABC transporter signature motif; other site
457570006564	Walker B; other site
457570006565	D-loop; other site
457570006566	H-loop/switch region; other site
457570006567	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
457570006568	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
457570006569	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
457570006570	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
457570006571	XdhC Rossmann domain; Region: XdhC_C; pfam13478
457570006572	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
457570006573	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
457570006574	MPT binding site; other site
457570006575	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
457570006576	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
457570006577	PYR/PP interface [polypeptide binding]; other site
457570006578	dimer interface [polypeptide binding]; other site
457570006579	TPP binding site [chemical binding]; other site
457570006580	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
457570006581	transketolase; Reviewed; Region: PRK05899
457570006582	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
457570006583	TPP-binding site [chemical binding]; other site
457570006584	dimer interface [polypeptide binding]; other site
457570006585	Uncharacterized conserved protein [Function unknown]; Region: COG1284
457570006586	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
457570006587	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
457570006588	peptide chain release factor 2; Validated; Region: prfB; PRK00578
457570006589	PCRF domain; Region: PCRF; pfam03462
457570006590	RF-1 domain; Region: RF-1; pfam00472
457570006591	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
457570006592	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
457570006593	ATP binding site [chemical binding]; other site
457570006594	putative Mg++ binding site [ion binding]; other site
457570006595	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
457570006596	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
457570006597	nucleotide binding region [chemical binding]; other site
457570006598	ATP-binding site [chemical binding]; other site
457570006599	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
457570006600	putative active site pocket [active]
457570006601	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
457570006602	cleavage site
457570006603	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
457570006604	30S subunit binding site; other site
457570006605	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
457570006606	DNA-binding site [nucleotide binding]; DNA binding site
457570006607	RNA-binding motif; other site
457570006608	PAS domain S-box; Region: sensory_box; TIGR00229
457570006609	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570006610	putative active site [active]
457570006611	heme pocket [chemical binding]; other site
457570006612	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570006613	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570006614	metal binding site [ion binding]; metal-binding site
457570006615	active site
457570006616	I-site; other site
457570006617	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570006618	Zn2+ binding site [ion binding]; other site
457570006619	Mg2+ binding site [ion binding]; other site
457570006620	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
457570006621	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
457570006622	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
457570006623	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
457570006624	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
457570006625	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
457570006626	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
457570006627	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
457570006628	FlaG protein; Region: FlaG; pfam03646
457570006629	flagellin; Reviewed; Region: PRK08869
457570006630	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
457570006631	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
457570006632	carbon storage regulator; Provisional; Region: PRK01712
457570006633	flagellar assembly protein FliW; Provisional; Region: PRK13285
457570006634	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
457570006635	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
457570006636	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
457570006637	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
457570006638	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
457570006639	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
457570006640	FlgN protein; Region: FlgN; pfam05130
457570006641	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
457570006642	flagellar operon protein TIGR03826; Region: YvyF
457570006643	Transcriptional regulators [Transcription]; Region: FadR; COG2186
457570006644	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
457570006645	DNA-binding site [nucleotide binding]; DNA binding site
457570006646	FCD domain; Region: FCD; pfam07729
457570006647	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
457570006648	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570006649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570006650	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570006651	Integrase core domain; Region: rve; pfam00665
457570006652	Integrase core domain; Region: rve_3; cl15866
457570006653	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
457570006654	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
457570006655	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
457570006656	homodimer interface [polypeptide binding]; other site
457570006657	substrate-cofactor binding pocket; other site
457570006658	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570006659	catalytic residue [active]
457570006660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570006661	Major Facilitator Superfamily; Region: MFS_1; pfam07690
457570006662	putative substrate translocation pore; other site
457570006663	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
457570006664	Coenzyme A transferase; Region: CoA_trans; cl17247
457570006665	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
457570006666	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
457570006667	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570006668	putative active site [active]
457570006669	heme pocket [chemical binding]; other site
457570006670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570006671	putative active site [active]
457570006672	heme pocket [chemical binding]; other site
457570006673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570006674	Walker A motif; other site
457570006675	ATP binding site [chemical binding]; other site
457570006676	Walker B motif; other site
457570006677	arginine finger; other site
457570006678	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
457570006679	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
457570006680	O-Antigen ligase; Region: Wzy_C; pfam04932
457570006681	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
457570006682	binding surface
457570006683	TPR motif; other site
457570006684	Tetratricopeptide repeat; Region: TPR_12; pfam13424
457570006685	S-layer homology domain; Region: SLH; pfam00395
457570006686	S-layer homology domain; Region: SLH; pfam00395
457570006687	Protein of unknown function (DUF554); Region: DUF554; pfam04474
457570006688	AAA domain; Region: AAA_31; pfam13614
457570006689	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
457570006690	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
457570006691	active site
457570006692	EDD domain protein, DegV family; Region: DegV; TIGR00762
457570006693	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
457570006694	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
457570006695	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
457570006696	ATP binding site [chemical binding]; other site
457570006697	putative Mg++ binding site [ion binding]; other site
457570006698	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
457570006699	nucleotide binding region [chemical binding]; other site
457570006700	ATP-binding site [chemical binding]; other site
457570006701	Peptidase C26; Region: Peptidase_C26; pfam07722
457570006702	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
457570006703	catalytic triad [active]
457570006704	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
457570006705	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
457570006706	HflX GTPase family; Region: HflX; cd01878
457570006707	G1 box; other site
457570006708	GTP/Mg2+ binding site [chemical binding]; other site
457570006709	Switch I region; other site
457570006710	G2 box; other site
457570006711	G3 box; other site
457570006712	Switch II region; other site
457570006713	G4 box; other site
457570006714	G5 box; other site
457570006715	Heme NO binding; Region: HNOB; pfam07700
457570006716	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
457570006717	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570006718	dimer interface [polypeptide binding]; other site
457570006719	putative CheW interface [polypeptide binding]; other site
457570006720	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
457570006721	Asp23 family; Region: Asp23; pfam03780
457570006722	Methyltransferase domain; Region: Methyltransf_23; pfam13489
457570006723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570006724	S-adenosylmethionine binding site [chemical binding]; other site
457570006725	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
457570006726	Helix-turn-helix domain; Region: HTH_28; pfam13518
457570006727	Winged helix-turn helix; Region: HTH_29; pfam13551
457570006728	Integrase core domain; Region: rve; pfam00665
457570006729	glutamine synthetase, type I; Region: GlnA; TIGR00653
457570006730	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
457570006731	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
457570006732	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
457570006733	dinuclear metal binding motif [ion binding]; other site
457570006734	QueT transporter; Region: QueT; pfam06177
457570006735	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
457570006736	Uncharacterized conserved protein [Function unknown]; Region: COG1432
457570006737	LabA_like proteins; Region: LabA_like; cd06167
457570006738	putative metal binding site [ion binding]; other site
457570006739	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
457570006740	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
457570006741	active site
457570006742	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
457570006743	hypothetical protein; Provisional; Region: PRK09947
457570006744	putative oxidoreductase; Provisional; Region: PRK09849
457570006745	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
457570006746	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
457570006747	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
457570006748	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
457570006749	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
457570006750	4Fe-4S binding domain; Region: Fer4; pfam00037
457570006751	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
457570006752	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
457570006753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570006754	S-adenosylmethionine binding site [chemical binding]; other site
457570006755	Sporulation and spore germination; Region: Germane; pfam10646
457570006756	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570006757	dimer interface [polypeptide binding]; other site
457570006758	conserved gate region; other site
457570006759	putative PBP binding loops; other site
457570006760	ABC-ATPase subunit interface; other site
457570006761	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
457570006762	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
457570006763	Walker A/P-loop; other site
457570006764	ATP binding site [chemical binding]; other site
457570006765	Q-loop/lid; other site
457570006766	ABC transporter signature motif; other site
457570006767	Walker B; other site
457570006768	D-loop; other site
457570006769	H-loop/switch region; other site
457570006770	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570006771	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
457570006772	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
457570006773	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
457570006774	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
457570006775	active site
457570006776	Methyltransferase domain; Region: Methyltransf_31; pfam13847
457570006777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570006778	S-adenosylmethionine binding site [chemical binding]; other site
457570006779	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
457570006780	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
457570006781	Ferredoxin [Energy production and conversion]; Region: COG1146
457570006782	4Fe-4S binding domain; Region: Fer4_6; pfam12837
457570006783	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
457570006784	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
457570006785	AAA-like domain; Region: AAA_10; pfam12846
457570006786	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
457570006787	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
457570006788	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
457570006789	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
457570006790	N-acetyl-D-glucosamine binding site [chemical binding]; other site
457570006791	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570006792	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
457570006793	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
457570006794	NodB motif; other site
457570006795	active site
457570006796	catalytic site [active]
457570006797	Zn binding site [ion binding]; other site
457570006798	Uncharacterized conserved protein [Function unknown]; Region: COG0398
457570006799	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
457570006800	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
457570006801	propionate/acetate kinase; Provisional; Region: PRK12379
457570006802	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
457570006803	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
457570006804	dimer interface [polypeptide binding]; other site
457570006805	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570006806	catalytic residue [active]
457570006807	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
457570006808	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
457570006809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570006810	Walker A motif; other site
457570006811	ATP binding site [chemical binding]; other site
457570006812	Walker B motif; other site
457570006813	arginine finger; other site
457570006814	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
457570006815	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
457570006816	active site
457570006817	tetramer interface [polypeptide binding]; other site
457570006818	AAA domain; Region: AAA_32; pfam13654
457570006819	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
457570006820	ATP-dependent protease Lon; Provisional; Region: PRK13765
457570006821	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
457570006822	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
457570006823	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
457570006824	DNA binding site [nucleotide binding]
457570006825	AAA domain; Region: AAA_30; pfam13604
457570006826	Family description; Region: UvrD_C_2; pfam13538
457570006827	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
457570006828	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
457570006829	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570006830	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570006831	metal binding site [ion binding]; metal-binding site
457570006832	active site
457570006833	I-site; other site
457570006834	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
457570006835	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
457570006836	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
457570006837	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
457570006838	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
457570006839	ATP binding site [chemical binding]; other site
457570006840	Walker A motif; other site
457570006841	hexamer interface [polypeptide binding]; other site
457570006842	Walker B motif; other site
457570006843	Response regulator receiver domain; Region: Response_reg; pfam00072
457570006844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570006845	active site
457570006846	phosphorylation site [posttranslational modification]
457570006847	intermolecular recognition site; other site
457570006848	dimerization interface [polypeptide binding]; other site
457570006849	AAA domain; Region: AAA_31; pfam13614
457570006850	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
457570006851	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
457570006852	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
457570006853	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
457570006854	TadE-like protein; Region: TadE; pfam07811
457570006855	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
457570006856	Flp/Fap pilin component; Region: Flp_Fap; cl01585
457570006857	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
457570006858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570006859	active site
457570006860	phosphorylation site [posttranslational modification]
457570006861	intermolecular recognition site; other site
457570006862	dimerization interface [polypeptide binding]; other site
457570006863	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
457570006864	DNA binding residues [nucleotide binding]
457570006865	dimerization interface [polypeptide binding]; other site
457570006866	Sensor protein DegS; Region: DegS; pfam05384
457570006867	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
457570006868	Histidine kinase; Region: HisKA_3; pfam07730
457570006869	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570006870	ATP binding site [chemical binding]; other site
457570006871	Mg2+ binding site [ion binding]; other site
457570006872	G-X-G motif; other site
457570006873	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
457570006874	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
457570006875	active site
457570006876	metal binding site [ion binding]; metal-binding site
457570006877	stage V sporulation protein B; Region: spore_V_B; TIGR02900
457570006878	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
457570006879	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
457570006880	S-adenosylmethionine synthetase; Validated; Region: PRK05250
457570006881	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
457570006882	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
457570006883	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
457570006884	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
457570006885	active site
457570006886	DNA polymerase IV; Validated; Region: PRK02406
457570006887	DNA binding site [nucleotide binding]
457570006888	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
457570006889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
457570006890	binding surface
457570006891	TPR motif; other site
457570006892	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
457570006893	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
457570006894	NAD binding site [chemical binding]; other site
457570006895	ligand binding site [chemical binding]; other site
457570006896	catalytic site [active]
457570006897	DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489
457570006898	Transposase, Mutator family; Region: Transposase_mut; pfam00872
457570006899	MULE transposase domain; Region: MULE; pfam10551
457570006900	metal-dependent hydrolase; Provisional; Region: PRK00685
457570006901	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
457570006902	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
457570006903	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
457570006904	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
457570006905	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
457570006906	catalytic residues [active]
457570006907	spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070
457570006908	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
457570006909	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
457570006910	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
457570006911	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
457570006912	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
457570006913	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
457570006914	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
457570006915	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
457570006916	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
457570006917	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
457570006918	nucleotide binding site [chemical binding]; other site
457570006919	Acetokinase family; Region: Acetate_kinase; cl17229
457570006920	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
457570006921	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
457570006922	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
457570006923	NAD binding site [chemical binding]; other site
457570006924	Phe binding site; other site
457570006925	Transcriptional regulator [Transcription]; Region: LysR; COG0583
457570006926	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
457570006927	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
457570006928	putative dimerization interface [polypeptide binding]; other site
457570006929	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
457570006930	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
457570006931	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
457570006932	Ligand Binding Site [chemical binding]; other site
457570006933	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
457570006934	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
457570006935	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
457570006936	catalytic residue [active]
457570006937	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
457570006938	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
457570006939	active site
457570006940	FMN binding site [chemical binding]; other site
457570006941	substrate binding site [chemical binding]; other site
457570006942	putative catalytic residue [active]
457570006943	plasmid segregation protein ParM; Provisional; Region: PRK13917
457570006944	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
457570006945	Mg binding site [ion binding]; other site
457570006946	nucleotide binding site [chemical binding]; other site
457570006947	putative protofilament interface [polypeptide binding]; other site
457570006948	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
457570006949	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
457570006950	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
457570006951	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
457570006952	metal binding triad [ion binding]; metal-binding site
457570006953	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
457570006954	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
457570006955	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
457570006956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
457570006957	Coenzyme A binding pocket [chemical binding]; other site
457570006958	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
457570006959	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
457570006960	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
457570006961	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
457570006962	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
457570006963	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
457570006964	Coenzyme A binding pocket [chemical binding]; other site
457570006965	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
457570006966	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
457570006967	Walker A/P-loop; other site
457570006968	ATP binding site [chemical binding]; other site
457570006969	Q-loop/lid; other site
457570006970	ABC transporter signature motif; other site
457570006971	Walker B; other site
457570006972	D-loop; other site
457570006973	H-loop/switch region; other site
457570006974	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
457570006975	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
457570006976	ABC-ATPase subunit  interface; other site
457570006977	dimer interface [polypeptide binding]; other site
457570006978	putative PBP binding regions; other site
457570006979	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
457570006980	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
457570006981	putative binding site residues; other site
457570006982	Integral membrane protein DUF95; Region: DUF95; cl00572
457570006983	Rubrerythrin [Energy production and conversion]; Region: COG1592
457570006984	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
457570006985	binuclear metal center [ion binding]; other site
457570006986	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
457570006987	iron binding site [ion binding]; other site
457570006988	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
457570006989	putative active site [active]
457570006990	catalytic triad [active]
457570006991	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
457570006992	putative integrin binding motif; other site
457570006993	PA/protease domain interface [polypeptide binding]; other site
457570006994	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
457570006995	FlgD Ig-like domain; Region: FlgD_ig; pfam13860
457570006996	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570006997	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570006998	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
457570006999	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
457570007000	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007001	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007002	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
457570007003	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
457570007004	Transcriptional regulator [Transcription]; Region: LysR; COG0583
457570007005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
457570007006	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
457570007007	putative dimerization interface [polypeptide binding]; other site
457570007008	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
457570007009	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570007010	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570007011	putative active site [active]
457570007012	putative NTP binding site [chemical binding]; other site
457570007013	putative nucleic acid binding site [nucleotide binding]; other site
457570007014	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570007015	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
457570007016	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
457570007017	Mg++ binding site [ion binding]; other site
457570007018	putative catalytic motif [active]
457570007019	substrate binding site [chemical binding]; other site
457570007020	Transcriptional regulator [Transcription]; Region: LytR; COG1316
457570007021	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
457570007022	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
457570007023	NAD(P) binding site [chemical binding]; other site
457570007024	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
457570007025	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
457570007026	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
457570007027	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
457570007028	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
457570007029	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
457570007030	putative homodimer interface [polypeptide binding]; other site
457570007031	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
457570007032	putative active site [active]
457570007033	putative metal binding site [ion binding]; other site
457570007034	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
457570007035	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
457570007036	NAD(P) binding site [chemical binding]; other site
457570007037	active site
457570007038	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
457570007039	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
457570007040	O-Antigen ligase; Region: Wzy_C; cl04850
457570007041	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
457570007042	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
457570007043	FtsX-like permease family; Region: FtsX; pfam02687
457570007044	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
457570007045	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
457570007046	Walker A/P-loop; other site
457570007047	ATP binding site [chemical binding]; other site
457570007048	Q-loop/lid; other site
457570007049	ABC transporter signature motif; other site
457570007050	Walker B; other site
457570007051	D-loop; other site
457570007052	H-loop/switch region; other site
457570007053	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
457570007054	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570007055	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
457570007056	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
457570007057	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
457570007058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570007059	dimer interface [polypeptide binding]; other site
457570007060	conserved gate region; other site
457570007061	putative PBP binding loops; other site
457570007062	ABC-ATPase subunit interface; other site
457570007063	dipeptide transporter; Provisional; Region: PRK10913
457570007064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570007065	dimer interface [polypeptide binding]; other site
457570007066	conserved gate region; other site
457570007067	putative PBP binding loops; other site
457570007068	ABC-ATPase subunit interface; other site
457570007069	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
457570007070	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570007071	Walker A/P-loop; other site
457570007072	ATP binding site [chemical binding]; other site
457570007073	Q-loop/lid; other site
457570007074	ABC transporter signature motif; other site
457570007075	Walker B; other site
457570007076	D-loop; other site
457570007077	H-loop/switch region; other site
457570007078	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570007079	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
457570007080	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570007081	Walker A/P-loop; other site
457570007082	ATP binding site [chemical binding]; other site
457570007083	Q-loop/lid; other site
457570007084	ABC transporter signature motif; other site
457570007085	Walker B; other site
457570007086	D-loop; other site
457570007087	H-loop/switch region; other site
457570007088	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
457570007089	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
457570007090	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
457570007091	putative metal binding site [ion binding]; other site
457570007092	putative acetyltransferase; Provisional; Region: PRK03624
457570007093	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
457570007094	Coenzyme A binding pocket [chemical binding]; other site
457570007095	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
457570007096	CoA binding domain; Region: CoA_binding; smart00881
457570007097	CoA-ligase; Region: Ligase_CoA; pfam00549
457570007098	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
457570007099	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
457570007100	CoA-ligase; Region: Ligase_CoA; pfam00549
457570007101	Fumarase C-terminus; Region: Fumerase_C; cl00795
457570007102	fumarate hydratase; Provisional; Region: PRK06246
457570007103	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
457570007104	Malic enzyme, N-terminal domain; Region: malic; pfam00390
457570007105	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
457570007106	putative NAD(P) binding site [chemical binding]; other site
457570007107	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
457570007108	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
457570007109	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
457570007110	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570007111	Walker A/P-loop; other site
457570007112	ATP binding site [chemical binding]; other site
457570007113	Q-loop/lid; other site
457570007114	ABC transporter signature motif; other site
457570007115	Walker B; other site
457570007116	D-loop; other site
457570007117	H-loop/switch region; other site
457570007118	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570007119	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
457570007120	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570007121	Walker A/P-loop; other site
457570007122	ATP binding site [chemical binding]; other site
457570007123	Q-loop/lid; other site
457570007124	ABC transporter signature motif; other site
457570007125	Walker B; other site
457570007126	D-loop; other site
457570007127	H-loop/switch region; other site
457570007128	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570007129	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
457570007130	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
457570007131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570007132	dimer interface [polypeptide binding]; other site
457570007133	conserved gate region; other site
457570007134	putative PBP binding loops; other site
457570007135	ABC-ATPase subunit interface; other site
457570007136	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
457570007137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570007138	dimer interface [polypeptide binding]; other site
457570007139	conserved gate region; other site
457570007140	putative PBP binding loops; other site
457570007141	ABC-ATPase subunit interface; other site
457570007142	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570007143	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
457570007144	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007145	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
457570007146	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
457570007147	Peptidase family M28; Region: Peptidase_M28; pfam04389
457570007148	metal binding site [ion binding]; metal-binding site
457570007149	GAF domain; Region: GAF_2; pfam13185
457570007150	GAF domain; Region: GAF; cl17456
457570007151	Sensory domain found in PocR; Region: PocR; pfam10114
457570007152	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570007153	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570007154	metal binding site [ion binding]; metal-binding site
457570007155	active site
457570007156	I-site; other site
457570007157	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570007158	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570007159	Zn2+ binding site [ion binding]; other site
457570007160	Mg2+ binding site [ion binding]; other site
457570007161	PAS fold; Region: PAS_4; pfam08448
457570007162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570007163	PAS fold; Region: PAS_3; pfam08447
457570007164	putative active site [active]
457570007165	heme pocket [chemical binding]; other site
457570007166	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570007167	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570007168	metal binding site [ion binding]; metal-binding site
457570007169	active site
457570007170	I-site; other site
457570007171	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570007172	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570007173	Zn2+ binding site [ion binding]; other site
457570007174	Mg2+ binding site [ion binding]; other site
457570007175	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570007176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570007177	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570007178	Integrase core domain; Region: rve; pfam00665
457570007179	Integrase core domain; Region: rve_3; cl15866
457570007180	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007181	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
457570007182	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007183	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
457570007184	HTH domain; Region: HTH_11; pfam08279
457570007185	3H domain; Region: 3H; pfam02829
457570007186	Quinolinate synthetase A protein; Region: NadA; pfam02445
457570007187	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
457570007188	L-aspartate oxidase; Provisional; Region: PRK06175
457570007189	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
457570007190	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
457570007191	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
457570007192	dimerization interface [polypeptide binding]; other site
457570007193	active site
457570007194	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570007195	FeS/SAM binding site; other site
457570007196	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
457570007197	putative DNA binding site [nucleotide binding]; other site
457570007198	putative Zn2+ binding site [ion binding]; other site
457570007199	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
457570007200	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570007201	DNA binding residues [nucleotide binding]
457570007202	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
457570007203	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
457570007204	P loop nucleotide binding; other site
457570007205	switch II; other site
457570007206	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
457570007207	P loop nucleotide binding; other site
457570007208	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
457570007209	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
457570007210	switch II; other site
457570007211	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
457570007212	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
457570007213	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570007214	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570007215	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570007216	Integrase core domain; Region: rve; pfam00665
457570007217	Integrase core domain; Region: rve_3; cl15866
457570007218	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570007219	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570007220	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570007221	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570007222	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570007223	putative active site [active]
457570007224	putative NTP binding site [chemical binding]; other site
457570007225	putative nucleic acid binding site [nucleotide binding]; other site
457570007226	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570007227	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
457570007228	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
457570007229	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
457570007230	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
457570007231	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
457570007232	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
457570007233	active site
457570007234	FMN binding site [chemical binding]; other site
457570007235	substrate binding site [chemical binding]; other site
457570007236	putative catalytic residue [active]
457570007237	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
457570007238	hypothetical protein; Provisional; Region: PRK06194
457570007239	classical (c) SDRs; Region: SDR_c; cd05233
457570007240	NAD(P) binding site [chemical binding]; other site
457570007241	active site
457570007242	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007243	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
457570007244	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
457570007245	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
457570007246	CPxP  motif; other site
457570007247	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
457570007248	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
457570007249	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
457570007250	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
457570007251	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
457570007252	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
457570007253	Walker A/P-loop; other site
457570007254	ATP binding site [chemical binding]; other site
457570007255	Q-loop/lid; other site
457570007256	ABC transporter signature motif; other site
457570007257	Walker B; other site
457570007258	D-loop; other site
457570007259	H-loop/switch region; other site
457570007260	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
457570007261	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570007262	FeS/SAM binding site; other site
457570007263	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
457570007264	PAS fold; Region: PAS_4; pfam08448
457570007265	PAS fold; Region: PAS_4; pfam08448
457570007266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570007267	putative active site [active]
457570007268	heme pocket [chemical binding]; other site
457570007269	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570007270	PAS fold; Region: PAS_3; pfam08447
457570007271	putative active site [active]
457570007272	heme pocket [chemical binding]; other site
457570007273	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570007274	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570007275	metal binding site [ion binding]; metal-binding site
457570007276	active site
457570007277	I-site; other site
457570007278	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
457570007279	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570007280	Zn2+ binding site [ion binding]; other site
457570007281	Mg2+ binding site [ion binding]; other site
457570007282	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
457570007283	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
457570007284	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
457570007285	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
457570007286	catalytic site [active]
457570007287	subunit interface [polypeptide binding]; other site
457570007288	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
457570007289	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
457570007290	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
457570007291	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
457570007292	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
457570007293	ATP-grasp domain; Region: ATP-grasp_4; cl17255
457570007294	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
457570007295	IMP binding site; other site
457570007296	dimer interface [polypeptide binding]; other site
457570007297	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
457570007298	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
457570007299	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570007300	dimer interface [polypeptide binding]; other site
457570007301	putative CheW interface [polypeptide binding]; other site
457570007302	Cache domain; Region: Cache_1; pfam02743
457570007303	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
457570007304	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
457570007305	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570007306	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
457570007307	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570007308	dimer interface [polypeptide binding]; other site
457570007309	putative CheW interface [polypeptide binding]; other site
457570007310	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570007311	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
457570007312	putative active site [active]
457570007313	heme pocket [chemical binding]; other site
457570007314	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570007315	putative active site [active]
457570007316	heme pocket [chemical binding]; other site
457570007317	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570007318	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570007319	metal binding site [ion binding]; metal-binding site
457570007320	active site
457570007321	I-site; other site
457570007322	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570007323	Zn2+ binding site [ion binding]; other site
457570007324	Mg2+ binding site [ion binding]; other site
457570007325	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
457570007326	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
457570007327	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570007328	dimer interface [polypeptide binding]; other site
457570007329	putative CheW interface [polypeptide binding]; other site
457570007330	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
457570007331	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
457570007332	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
457570007333	homodimer interface [polypeptide binding]; other site
457570007334	substrate-cofactor binding pocket; other site
457570007335	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570007336	catalytic residue [active]
457570007337	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
457570007338	Spore germination protein; Region: Spore_permease; cl17796
457570007339	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
457570007340	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
457570007341	Helix-turn-helix domain; Region: HTH_28; pfam13518
457570007342	Winged helix-turn helix; Region: HTH_29; pfam13551
457570007343	Integrase core domain; Region: rve; pfam00665
457570007344	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
457570007345	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
457570007346	metal-binding site [ion binding]
457570007347	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
457570007348	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
457570007349	metal-binding site [ion binding]
457570007350	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
457570007351	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
457570007352	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
457570007353	dimerization interface [polypeptide binding]; other site
457570007354	putative DNA binding site [nucleotide binding]; other site
457570007355	putative Zn2+ binding site [ion binding]; other site
457570007356	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
457570007357	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
457570007358	Soluble P-type ATPase [General function prediction only]; Region: COG4087
457570007359	FMN-binding domain; Region: FMN_bind; pfam04205
457570007360	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
457570007361	L-aspartate oxidase; Provisional; Region: PRK06175
457570007362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570007363	Response regulator receiver domain; Region: Response_reg; pfam00072
457570007364	active site
457570007365	phosphorylation site [posttranslational modification]
457570007366	intermolecular recognition site; other site
457570007367	dimerization interface [polypeptide binding]; other site
457570007368	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
457570007369	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
457570007370	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
457570007371	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
457570007372	Bacterial transcriptional activator domain; Region: BTAD; smart01043
457570007373	Cobalt transport protein; Region: CbiQ; cl00463
457570007374	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647
457570007375	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
457570007376	Walker A/P-loop; other site
457570007377	ATP binding site [chemical binding]; other site
457570007378	Q-loop/lid; other site
457570007379	ABC transporter signature motif; other site
457570007380	Walker B; other site
457570007381	D-loop; other site
457570007382	H-loop/switch region; other site
457570007383	cobalt transport protein CbiM; Validated; Region: PRK06265
457570007384	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
457570007385	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
457570007386	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
457570007387	dimer interface [polypeptide binding]; other site
457570007388	active site
457570007389	glycine loop; other site
457570007390	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
457570007391	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
457570007392	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
457570007393	FeS/SAM binding site; other site
457570007394	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
457570007395	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
457570007396	Sporulation and spore germination; Region: Germane; pfam10646
457570007397	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
457570007398	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
457570007399	Active site serine [active]
457570007400	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
457570007401	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
457570007402	active site triad [active]
457570007403	Putative transcription activator [Transcription]; Region: TenA; COG0819
457570007404	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
457570007405	substrate binding site [chemical binding]; other site
457570007406	multimerization interface [polypeptide binding]; other site
457570007407	ATP binding site [chemical binding]; other site
457570007408	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
457570007409	dimer interface [polypeptide binding]; other site
457570007410	substrate binding site [chemical binding]; other site
457570007411	ATP binding site [chemical binding]; other site
457570007412	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
457570007413	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
457570007414	Probable transposase; Region: OrfB_IS605; pfam01385
457570007415	Transposase IS200 like; Region: Y1_Tnp; pfam01797
457570007416	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007417	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
457570007418	active site
457570007419	NTP binding site [chemical binding]; other site
457570007420	metal binding triad [ion binding]; metal-binding site
457570007421	antibiotic binding site [chemical binding]; other site
457570007422	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007423	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
457570007424	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
457570007425	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007426	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
457570007427	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
457570007428	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
457570007429	NAD(P) binding site [chemical binding]; other site
457570007430	homodimer interface [polypeptide binding]; other site
457570007431	substrate binding site [chemical binding]; other site
457570007432	active site
457570007433	Radical SAM superfamily; Region: Radical_SAM; pfam04055
457570007434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570007435	FeS/SAM binding site; other site
457570007436	Chain length determinant protein; Region: Wzz; pfam02706
457570007437	O-Antigen ligase; Region: Wzy_C; cl04850
457570007438	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
457570007439	O-Antigen ligase; Region: Wzy_C; pfam04932
457570007440	O-Antigen ligase; Region: Wzy_C; cl04850
457570007441	TPR repeat; Region: TPR_11; pfam13414
457570007442	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
457570007443	TPR motif; other site
457570007444	binding surface
457570007445	Tetratricopeptide repeat; Region: TPR_12; pfam13424
457570007446	Domain of unknown function (DUF955); Region: DUF955; pfam06114
457570007447	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
457570007448	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570007449	non-specific DNA binding site [nucleotide binding]; other site
457570007450	salt bridge; other site
457570007451	sequence-specific DNA binding site [nucleotide binding]; other site
457570007452	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
457570007453	Probable transposase; Region: OrfB_IS605; pfam01385
457570007454	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
457570007455	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
457570007456	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
457570007457	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570007458	non-specific DNA binding site [nucleotide binding]; other site
457570007459	salt bridge; other site
457570007460	sequence-specific DNA binding site [nucleotide binding]; other site
457570007461	Domain of unknown function (DUF955); Region: DUF955; cl01076
457570007462	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
457570007463	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
457570007464	inhibitor-cofactor binding pocket; inhibition site
457570007465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570007466	catalytic residue [active]
457570007467	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
457570007468	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
457570007469	Bacterial sugar transferase; Region: Bac_transf; pfam02397
457570007470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570007471	Transposase; Region: HTH_Tnp_1; pfam01527
457570007472	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
457570007473	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
457570007474	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
457570007475	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
457570007476	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
457570007477	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
457570007478	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
457570007479	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
457570007480	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
457570007481	VPS10 domain; Region: VPS10; smart00602
457570007482	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
457570007483	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
457570007484	O-Antigen ligase; Region: Wzy_C; pfam04932
457570007485	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
457570007486	active site
457570007487	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
457570007488	Ligand Binding Site [chemical binding]; other site
457570007489	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
457570007490	MviN-like protein; Region: MVIN; pfam03023
457570007491	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
457570007492	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
457570007493	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
457570007494	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
457570007495	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
457570007496	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
457570007497	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
457570007498	active site
457570007499	tetramer interface; other site
457570007500	Domain of unknown function (DUF955); Region: DUF955; cl01076
457570007501	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570007502	non-specific DNA binding site [nucleotide binding]; other site
457570007503	salt bridge; other site
457570007504	sequence-specific DNA binding site [nucleotide binding]; other site
457570007505	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
457570007506	amidase catalytic site [active]
457570007507	Zn binding residues [ion binding]; other site
457570007508	substrate binding site [chemical binding]; other site
457570007509	YvrJ protein family; Region: YvrJ; pfam12841
457570007510	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
457570007511	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
457570007512	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570007513	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570007514	putative active site [active]
457570007515	putative NTP binding site [chemical binding]; other site
457570007516	putative nucleic acid binding site [nucleotide binding]; other site
457570007517	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570007518	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570007519	Transposase; Region: HTH_Tnp_1; pfam01527
457570007520	SEC-C motif; Region: SEC-C; pfam02810
457570007521	Protein of unknown function DUF86; Region: DUF86; pfam01934
457570007522	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
457570007523	active site
457570007524	NTP binding site [chemical binding]; other site
457570007525	metal binding triad [ion binding]; metal-binding site
457570007526	antibiotic binding site [chemical binding]; other site
457570007527	S-layer homology domain; Region: SLH; pfam00395
457570007528	S-layer homology domain; Region: SLH; pfam00395
457570007529	Protein of unknown function DUF86; Region: DUF86; pfam01934
457570007530	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
457570007531	active site
457570007532	NTP binding site [chemical binding]; other site
457570007533	metal binding triad [ion binding]; metal-binding site
457570007534	antibiotic binding site [chemical binding]; other site
457570007535	Fic family protein [Function unknown]; Region: COG3177
457570007536	Fic/DOC family; Region: Fic; pfam02661
457570007537	SEC-C motif; Region: SEC-C; pfam02810
457570007538	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
457570007539	metal binding triad [ion binding]; metal-binding site
457570007540	Protein of unknown function DUF86; Region: DUF86; pfam01934
457570007541	Creatinine amidohydrolase; Region: Creatininase; pfam02633
457570007542	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
457570007543	Na binding site [ion binding]; other site
457570007544	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
457570007545	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570007546	non-specific DNA binding site [nucleotide binding]; other site
457570007547	salt bridge; other site
457570007548	sequence-specific DNA binding site [nucleotide binding]; other site
457570007549	Cupin domain; Region: Cupin_2; pfam07883
457570007550	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
457570007551	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
457570007552	active site
457570007553	FMN binding site [chemical binding]; other site
457570007554	substrate binding site [chemical binding]; other site
457570007555	putative catalytic residue [active]
457570007556	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
457570007557	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570007558	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
457570007559	active site
457570007560	NTP binding site [chemical binding]; other site
457570007561	metal binding triad [ion binding]; metal-binding site
457570007562	antibiotic binding site [chemical binding]; other site
457570007563	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
457570007564	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
457570007565	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
457570007566	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
457570007567	spiro-SPASM protein; Region: spiroSPASM; TIGR04321
457570007568	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570007569	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
457570007570	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
457570007571	Cache domain; Region: Cache_1; pfam02743
457570007572	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
457570007573	dimerization interface [polypeptide binding]; other site
457570007574	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
457570007575	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570007576	dimer interface [polypeptide binding]; other site
457570007577	putative CheW interface [polypeptide binding]; other site
457570007578	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570007579	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570007580	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
457570007581	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570007582	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570007583	helix-hairpin-helix signature motif; other site
457570007584	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
457570007585	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
457570007586	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570007587	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570007588	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570007589	Penicillinase repressor; Region: Pencillinase_R; pfam03965
457570007590	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
457570007591	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
457570007592	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
457570007593	molybdopterin cofactor binding site; other site
457570007594	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
457570007595	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
457570007596	molybdopterin cofactor binding site; other site
457570007597	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
457570007598	4Fe-4S binding domain; Region: Fer4; pfam00037
457570007599	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
457570007600	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
457570007601	SLBB domain; Region: SLBB; pfam10531
457570007602	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570007603	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
457570007604	KWG Leptospira; Region: KWG; pfam07656
457570007605	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
457570007606	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570007607	active site
457570007608	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
457570007609	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
457570007610	NAD(P) binding site [chemical binding]; other site
457570007611	homotetramer interface [polypeptide binding]; other site
457570007612	homodimer interface [polypeptide binding]; other site
457570007613	active site
457570007614	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
457570007615	Coenzyme A transferase; Region: CoA_trans; smart00882
457570007616	Coenzyme A transferase; Region: CoA_trans; cl17247
457570007617	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
457570007618	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570007619	putative active site [active]
457570007620	heme pocket [chemical binding]; other site
457570007621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570007622	Walker A motif; other site
457570007623	ATP binding site [chemical binding]; other site
457570007624	Walker B motif; other site
457570007625	arginine finger; other site
457570007626	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
457570007627	germination protein YpeB; Region: spore_YpeB; TIGR02889
457570007628	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
457570007629	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
457570007630	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570007631	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570007632	DNA binding residues [nucleotide binding]
457570007633	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570007634	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570007635	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570007636	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
457570007637	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
457570007638	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
457570007639	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
457570007640	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
457570007641	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
457570007642	HSP70 interaction site [polypeptide binding]; other site
457570007643	RDD family; Region: RDD; cl00746
457570007644	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
457570007645	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
457570007646	Walker A/P-loop; other site
457570007647	ATP binding site [chemical binding]; other site
457570007648	Q-loop/lid; other site
457570007649	ABC transporter signature motif; other site
457570007650	Walker B; other site
457570007651	D-loop; other site
457570007652	H-loop/switch region; other site
457570007653	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
457570007654	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
457570007655	ABC-ATPase subunit  interface; other site
457570007656	dimer interface [polypeptide binding]; other site
457570007657	putative PBP binding regions; other site
457570007658	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
457570007659	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
457570007660	intersubunit interface [polypeptide binding]; other site
457570007661	Domain of unknown function (DUF4203); Region: DUF4203; pfam13886
457570007662	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
457570007663	Right handed beta helix region; Region: Beta_helix; pfam13229
457570007664	Response regulator receiver domain; Region: Response_reg; pfam00072
457570007665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570007666	active site
457570007667	phosphorylation site [posttranslational modification]
457570007668	intermolecular recognition site; other site
457570007669	dimerization interface [polypeptide binding]; other site
457570007670	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
457570007671	Accessory gene regulator B; Region: AgrB; pfam04647
457570007672	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
457570007673	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
457570007674	FtsX-like permease family; Region: FtsX; pfam02687
457570007675	S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361
457570007676	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
457570007677	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
457570007678	Walker A/P-loop; other site
457570007679	ATP binding site [chemical binding]; other site
457570007680	Q-loop/lid; other site
457570007681	ABC transporter signature motif; other site
457570007682	Walker B; other site
457570007683	D-loop; other site
457570007684	H-loop/switch region; other site
457570007685	Response regulator receiver domain; Region: Response_reg; pfam00072
457570007686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570007687	active site
457570007688	phosphorylation site [posttranslational modification]
457570007689	intermolecular recognition site; other site
457570007690	dimerization interface [polypeptide binding]; other site
457570007691	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
457570007692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570007693	ATP binding site [chemical binding]; other site
457570007694	Mg2+ binding site [ion binding]; other site
457570007695	G-X-G motif; other site
457570007696	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
457570007697	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
457570007698	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
457570007699	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
457570007700	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
457570007701	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
457570007702	active site
457570007703	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
457570007704	Beta-lactamase; Region: Beta-lactamase; pfam00144
457570007705	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
457570007706	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
457570007707	DDE domain; Region: DDE_Tnp_IS240; pfam13610
457570007708	Integrase core domain; Region: rve; pfam00665
457570007709	Integrase core domain; Region: rve_3; cl15866
457570007710	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
457570007711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570007712	dimer interface [polypeptide binding]; other site
457570007713	conserved gate region; other site
457570007714	putative PBP binding loops; other site
457570007715	ABC-ATPase subunit interface; other site
457570007716	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
457570007717	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
457570007718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570007719	dimer interface [polypeptide binding]; other site
457570007720	conserved gate region; other site
457570007721	putative PBP binding loops; other site
457570007722	ABC-ATPase subunit interface; other site
457570007723	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
457570007724	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570007725	Walker A/P-loop; other site
457570007726	ATP binding site [chemical binding]; other site
457570007727	Q-loop/lid; other site
457570007728	ABC transporter signature motif; other site
457570007729	Walker B; other site
457570007730	D-loop; other site
457570007731	H-loop/switch region; other site
457570007732	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
457570007733	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
457570007734	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570007735	Walker A/P-loop; other site
457570007736	ATP binding site [chemical binding]; other site
457570007737	Q-loop/lid; other site
457570007738	ABC transporter signature motif; other site
457570007739	Walker B; other site
457570007740	D-loop; other site
457570007741	H-loop/switch region; other site
457570007742	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570007743	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570007744	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
457570007745	peptide binding site [polypeptide binding]; other site
457570007746	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
457570007747	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570007748	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
457570007749	active site
457570007750	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
457570007751	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007752	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007753	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
457570007754	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
457570007755	active site
457570007756	homodimer interface [polypeptide binding]; other site
457570007757	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
457570007758	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570007759	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570007760	putative active site [active]
457570007761	putative NTP binding site [chemical binding]; other site
457570007762	putative nucleic acid binding site [nucleotide binding]; other site
457570007763	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570007764	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570007765	dimer interface [polypeptide binding]; other site
457570007766	putative CheW interface [polypeptide binding]; other site
457570007767	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
457570007768	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570007769	dimer interface [polypeptide binding]; other site
457570007770	putative CheW interface [polypeptide binding]; other site
457570007771	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007772	NPCBM/NEW2 domain; Region: NPCBM; cl07060
457570007773	VPS10 domain; Region: VPS10; smart00602
457570007774	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
457570007775	transmembrane helices; other site
457570007776	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
457570007777	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
457570007778	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
457570007779	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
457570007780	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
457570007781	FAD binding pocket [chemical binding]; other site
457570007782	FAD binding motif [chemical binding]; other site
457570007783	phosphate binding motif [ion binding]; other site
457570007784	beta-alpha-beta structure motif; other site
457570007785	NAD binding pocket [chemical binding]; other site
457570007786	Iron coordination center [ion binding]; other site
457570007787	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
457570007788	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570007789	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
457570007790	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
457570007791	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570007792	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
457570007793	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
457570007794	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
457570007795	4Fe-4S binding domain; Region: Fer4; pfam00037
457570007796	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570007797	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
457570007798	Cysteine-rich domain; Region: CCG; pfam02754
457570007799	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
457570007800	Cysteine-rich domain; Region: CCG; pfam02754
457570007801	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
457570007802	L-aspartate oxidase; Provisional; Region: PRK06175
457570007803	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570007804	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
457570007805	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
457570007806	Aspartase; Region: Aspartase; cd01357
457570007807	active sites [active]
457570007808	tetramer interface [polypeptide binding]; other site
457570007809	Predicted membrane protein [Function unknown]; Region: COG1288
457570007810	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
457570007811	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
457570007812	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
457570007813	metal binding site [ion binding]; metal-binding site
457570007814	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
457570007815	putative DNA binding site [nucleotide binding]; other site
457570007816	dimerization interface [polypeptide binding]; other site
457570007817	Transcriptional regulator [Transcription]; Region: IclR; COG1414
457570007818	putative Zn2+ binding site [ion binding]; other site
457570007819	Bacterial transcriptional regulator; Region: IclR; pfam01614
457570007820	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
457570007821	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
457570007822	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
457570007823	Mg binding site [ion binding]; other site
457570007824	nucleotide binding site [chemical binding]; other site
457570007825	putative protofilament interface [polypeptide binding]; other site
457570007826	glycerol kinase; Provisional; Region: glpK; PRK00047
457570007827	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
457570007828	N- and C-terminal domain interface [polypeptide binding]; other site
457570007829	active site
457570007830	MgATP binding site [chemical binding]; other site
457570007831	catalytic site [active]
457570007832	metal binding site [ion binding]; metal-binding site
457570007833	glycerol binding site [chemical binding]; other site
457570007834	homotetramer interface [polypeptide binding]; other site
457570007835	homodimer interface [polypeptide binding]; other site
457570007836	FBP binding site [chemical binding]; other site
457570007837	protein IIAGlc interface [polypeptide binding]; other site
457570007838	benzoate transport; Region: 2A0115; TIGR00895
457570007839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570007840	putative substrate translocation pore; other site
457570007841	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
457570007842	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
457570007843	homodimer interface [polypeptide binding]; other site
457570007844	substrate-cofactor binding pocket; other site
457570007845	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570007846	catalytic residue [active]
457570007847	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
457570007848	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
457570007849	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
457570007850	flagellar operon protein TIGR03826; Region: YvyF
457570007851	FMN-binding domain; Region: FMN_bind; cl01081
457570007852	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007853	FMN-binding domain; Region: FMN_bind; pfam04205
457570007854	FMN-binding domain; Region: FMN_bind; cl01081
457570007855	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
457570007856	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
457570007857	Ferritin-like domain; Region: Ferritin; pfam00210
457570007858	ferroxidase diiron center [ion binding]; other site
457570007859	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570007860	dimer interface [polypeptide binding]; other site
457570007861	putative CheW interface [polypeptide binding]; other site
457570007862	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
457570007863	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
457570007864	ligand binding site [chemical binding]; other site
457570007865	dimerization interface [polypeptide binding]; other site
457570007866	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
457570007867	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
457570007868	TM-ABC transporter signature motif; other site
457570007869	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
457570007870	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
457570007871	Walker A/P-loop; other site
457570007872	ATP binding site [chemical binding]; other site
457570007873	Q-loop/lid; other site
457570007874	ABC transporter signature motif; other site
457570007875	Walker B; other site
457570007876	D-loop; other site
457570007877	H-loop/switch region; other site
457570007878	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
457570007879	D-ribose pyranase; Provisional; Region: PRK11797
457570007880	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
457570007881	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
457570007882	substrate binding site [chemical binding]; other site
457570007883	dimer interface [polypeptide binding]; other site
457570007884	ATP binding site [chemical binding]; other site
457570007885	Transcriptional regulators [Transcription]; Region: PurR; COG1609
457570007886	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
457570007887	DNA binding site [nucleotide binding]
457570007888	domain linker motif; other site
457570007889	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
457570007890	dimerization interface [polypeptide binding]; other site
457570007891	ligand binding site [chemical binding]; other site
457570007892	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
457570007893	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
457570007894	S-layer homology domain; Region: SLH; pfam00395
457570007895	S-layer homology domain; Region: SLH; pfam00395
457570007896	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
457570007897	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
457570007898	DNA binding site [nucleotide binding]
457570007899	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
457570007900	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
457570007901	I-site; other site
457570007902	active site
457570007903	metal binding site [ion binding]; metal-binding site
457570007904	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
457570007905	active site
457570007906	catalytic triad [active]
457570007907	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
457570007908	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
457570007909	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
457570007910	catalytic residue [active]
457570007911	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
457570007912	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
457570007913	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
457570007914	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
457570007915	dimer interface [polypeptide binding]; other site
457570007916	PYR/PP interface [polypeptide binding]; other site
457570007917	TPP binding site [chemical binding]; other site
457570007918	substrate binding site [chemical binding]; other site
457570007919	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
457570007920	TPP-binding site; other site
457570007921	4Fe-4S binding domain; Region: Fer4; pfam00037
457570007922	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
457570007923	butyrate kinase; Provisional; Region: PRK03011
457570007924	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
457570007925	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
457570007926	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
457570007927	NAD binding site [chemical binding]; other site
457570007928	Phe binding site; other site
457570007929	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
457570007930	Transcriptional regulator [Transcription]; Region: IclR; COG1414
457570007931	Bacterial transcriptional regulator; Region: IclR; pfam01614
457570007932	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
457570007933	Helix-turn-helix domain; Region: HTH_28; pfam13518
457570007934	Winged helix-turn helix; Region: HTH_29; pfam13551
457570007935	Integrase core domain; Region: rve; pfam00665
457570007936	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
457570007937	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
457570007938	dimer interface [polypeptide binding]; other site
457570007939	active site
457570007940	metal binding site [ion binding]; metal-binding site
457570007941	Methyltransferase domain; Region: Methyltransf_23; pfam13489
457570007942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570007943	S-adenosylmethionine binding site [chemical binding]; other site
457570007944	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
457570007945	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
457570007946	metal binding site [ion binding]; metal-binding site
457570007947	dimer interface [polypeptide binding]; other site
457570007948	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
457570007949	Na binding site [ion binding]; other site
457570007950	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570007951	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
457570007952	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
457570007953	active site
457570007954	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
457570007955	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
457570007956	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
457570007957	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570007958	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
457570007959	active site
457570007960	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
457570007961	active site
457570007962	DNA binding site [nucleotide binding]
457570007963	Int/Topo IB signature motif; other site
457570007964	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
457570007965	tandem repeat interface [polypeptide binding]; other site
457570007966	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
457570007967	oligomer interface [polypeptide binding]; other site
457570007968	active site residues [active]
457570007969	Domain of unknown function (DUF368); Region: DUF368; cl00893
457570007970	Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950
457570007971	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
457570007972	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
457570007973	CoenzymeA binding site [chemical binding]; other site
457570007974	subunit interaction site [polypeptide binding]; other site
457570007975	PHB binding site; other site
457570007976	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
457570007977	Beta-lactamase; Region: Beta-lactamase; pfam00144
457570007978	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
457570007979	Uncharacterized conserved protein [Function unknown]; Region: COG0432
457570007980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570007981	Major Facilitator Superfamily; Region: MFS_1; pfam07690
457570007982	putative substrate translocation pore; other site
457570007983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570007984	putative substrate translocation pore; other site
457570007985	EamA-like transporter family; Region: EamA; pfam00892
457570007986	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
457570007987	EamA-like transporter family; Region: EamA; pfam00892
457570007988	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
457570007989	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
457570007990	dimer interface [polypeptide binding]; other site
457570007991	active site
457570007992	CoA binding pocket [chemical binding]; other site
457570007993	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
457570007994	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
457570007995	TAP-like protein; Region: Abhydrolase_4; pfam08386
457570007996	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
457570007997	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
457570007998	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570007999	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570008000	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570008001	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570008002	Transposase; Region: DEDD_Tnp_IS110; pfam01548
457570008003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
457570008004	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
457570008005	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
457570008006	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
457570008007	Walker A/P-loop; other site
457570008008	ATP binding site [chemical binding]; other site
457570008009	Q-loop/lid; other site
457570008010	ABC transporter signature motif; other site
457570008011	Walker B; other site
457570008012	D-loop; other site
457570008013	H-loop/switch region; other site
457570008014	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
457570008015	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
457570008016	TM-ABC transporter signature motif; other site
457570008017	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
457570008018	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
457570008019	TM-ABC transporter signature motif; other site
457570008020	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
457570008021	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
457570008022	PAS domain; Region: PAS_9; pfam13426
457570008023	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
457570008024	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
457570008025	Walker A motif; other site
457570008026	ATP binding site [chemical binding]; other site
457570008027	Walker B motif; other site
457570008028	arginine finger; other site
457570008029	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
457570008030	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
457570008031	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
457570008032	NAD(P) binding site [chemical binding]; other site
457570008033	homotetramer interface [polypeptide binding]; other site
457570008034	homodimer interface [polypeptide binding]; other site
457570008035	active site
457570008036	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
457570008037	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
457570008038	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
457570008039	hypothetical protein; Validated; Region: PRK06840
457570008040	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
457570008041	active site
457570008042	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
457570008043	putative active site [active]
457570008044	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
457570008045	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
457570008046	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
457570008047	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
457570008048	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
457570008049	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
457570008050	tetramer interface [polypeptide binding]; other site
457570008051	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570008052	catalytic residue [active]
457570008053	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
457570008054	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
457570008055	tetramer interface [polypeptide binding]; other site
457570008056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
457570008057	catalytic residue [active]
457570008058	glycine cleavage system protein H; Provisional; Region: PRK13380
457570008059	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
457570008060	lipoyl attachment site [posttranslational modification]; other site
457570008061	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
457570008062	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
457570008063	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
457570008064	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
457570008065	active site
457570008066	putative substrate binding pocket [chemical binding]; other site
457570008067	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570008068	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
457570008069	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570008070	Walker A/P-loop; other site
457570008071	ATP binding site [chemical binding]; other site
457570008072	Q-loop/lid; other site
457570008073	ABC transporter signature motif; other site
457570008074	Walker B; other site
457570008075	D-loop; other site
457570008076	H-loop/switch region; other site
457570008077	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
457570008078	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
457570008079	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570008080	Walker A/P-loop; other site
457570008081	ATP binding site [chemical binding]; other site
457570008082	Q-loop/lid; other site
457570008083	ABC transporter signature motif; other site
457570008084	Walker B; other site
457570008085	D-loop; other site
457570008086	H-loop/switch region; other site
457570008087	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570008088	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
457570008089	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
457570008090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570008091	dimer interface [polypeptide binding]; other site
457570008092	conserved gate region; other site
457570008093	putative PBP binding loops; other site
457570008094	ABC-ATPase subunit interface; other site
457570008095	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
457570008096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570008097	dimer interface [polypeptide binding]; other site
457570008098	conserved gate region; other site
457570008099	putative PBP binding loops; other site
457570008100	ABC-ATPase subunit interface; other site
457570008101	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570008102	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
457570008103	agmatinase; Region: agmatinase; TIGR01230
457570008104	Arginase family; Region: Arginase; pfam00491
457570008105	active site
457570008106	metal binding site [ion binding]; metal-binding site
457570008107	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
457570008108	active site
457570008109	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
457570008110	active site
457570008111	dimer interface [polypeptide binding]; other site
457570008112	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
457570008113	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
457570008114	heterodimer interface [polypeptide binding]; other site
457570008115	active site
457570008116	FMN binding site [chemical binding]; other site
457570008117	homodimer interface [polypeptide binding]; other site
457570008118	substrate binding site [chemical binding]; other site
457570008119	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
457570008120	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
457570008121	FAD binding pocket [chemical binding]; other site
457570008122	FAD binding motif [chemical binding]; other site
457570008123	phosphate binding motif [ion binding]; other site
457570008124	beta-alpha-beta structure motif; other site
457570008125	NAD binding pocket [chemical binding]; other site
457570008126	Iron coordination center [ion binding]; other site
457570008127	dihydroorotase; Validated; Region: pyrC; PRK09357
457570008128	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570008129	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
457570008130	active site
457570008131	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
457570008132	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
457570008133	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
457570008134	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
457570008135	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
457570008136	active site
457570008137	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
457570008138	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
457570008139	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570008140	D-galactonate transporter; Region: 2A0114; TIGR00893
457570008141	putative substrate translocation pore; other site
457570008142	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
457570008143	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
457570008144	active site
457570008145	dimer interface [polypeptide binding]; other site
457570008146	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
457570008147	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
457570008148	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
457570008149	active site
457570008150	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
457570008151	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
457570008152	active site
457570008153	trimer interface [polypeptide binding]; other site
457570008154	allosteric site; other site
457570008155	active site lid [active]
457570008156	hexamer (dimer of trimers) interface [polypeptide binding]; other site
457570008157	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
457570008158	HPr interaction site; other site
457570008159	glycerol kinase (GK) interaction site [polypeptide binding]; other site
457570008160	active site
457570008161	phosphorylation site [posttranslational modification]
457570008162	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
457570008163	active site
457570008164	motif I; other site
457570008165	motif II; other site
457570008166	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
457570008167	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
457570008168	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
457570008169	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
457570008170	dimer interface [polypeptide binding]; other site
457570008171	PYR/PP interface [polypeptide binding]; other site
457570008172	TPP binding site [chemical binding]; other site
457570008173	substrate binding site [chemical binding]; other site
457570008174	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
457570008175	TPP-binding site; other site
457570008176	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570008177	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570008178	putative active site [active]
457570008179	putative NTP binding site [chemical binding]; other site
457570008180	putative nucleic acid binding site [nucleotide binding]; other site
457570008181	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570008182	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
457570008183	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
457570008184	G1 box; other site
457570008185	GTP/Mg2+ binding site [chemical binding]; other site
457570008186	G2 box; other site
457570008187	Switch I region; other site
457570008188	G3 box; other site
457570008189	Switch II region; other site
457570008190	G4 box; other site
457570008191	G5 box; other site
457570008192	Nucleoside recognition; Region: Gate; pfam07670
457570008193	Nucleoside recognition; Region: Gate; pfam07670
457570008194	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
457570008195	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
457570008196	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
457570008197	putative metal binding site [ion binding]; other site
457570008198	putative dimer interface [polypeptide binding]; other site
457570008199	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
457570008200	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570008201	Walker A/P-loop; other site
457570008202	ATP binding site [chemical binding]; other site
457570008203	Q-loop/lid; other site
457570008204	ABC transporter signature motif; other site
457570008205	Walker B; other site
457570008206	D-loop; other site
457570008207	H-loop/switch region; other site
457570008208	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
457570008209	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
457570008210	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570008211	Walker A/P-loop; other site
457570008212	ATP binding site [chemical binding]; other site
457570008213	Q-loop/lid; other site
457570008214	ABC transporter signature motif; other site
457570008215	Walker B; other site
457570008216	D-loop; other site
457570008217	H-loop/switch region; other site
457570008218	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570008219	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
457570008220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570008221	dimer interface [polypeptide binding]; other site
457570008222	conserved gate region; other site
457570008223	putative PBP binding loops; other site
457570008224	ABC-ATPase subunit interface; other site
457570008225	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
457570008226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570008227	dimer interface [polypeptide binding]; other site
457570008228	conserved gate region; other site
457570008229	putative PBP binding loops; other site
457570008230	ABC-ATPase subunit interface; other site
457570008231	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570008232	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
457570008233	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
457570008234	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
457570008235	metal binding site [ion binding]; metal-binding site
457570008236	dimer interface [polypeptide binding]; other site
457570008237	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
457570008238	putative metal binding site [ion binding]; other site
457570008239	putative dimer interface [polypeptide binding]; other site
457570008240	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
457570008241	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570008242	Walker A/P-loop; other site
457570008243	ATP binding site [chemical binding]; other site
457570008244	Q-loop/lid; other site
457570008245	ABC transporter signature motif; other site
457570008246	Walker B; other site
457570008247	D-loop; other site
457570008248	H-loop/switch region; other site
457570008249	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570008250	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
457570008251	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
457570008252	Walker A/P-loop; other site
457570008253	ATP binding site [chemical binding]; other site
457570008254	Q-loop/lid; other site
457570008255	ABC transporter signature motif; other site
457570008256	Walker B; other site
457570008257	D-loop; other site
457570008258	H-loop/switch region; other site
457570008259	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
457570008260	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
457570008261	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
457570008262	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570008263	dimer interface [polypeptide binding]; other site
457570008264	conserved gate region; other site
457570008265	putative PBP binding loops; other site
457570008266	ABC-ATPase subunit interface; other site
457570008267	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
457570008268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570008269	dimer interface [polypeptide binding]; other site
457570008270	conserved gate region; other site
457570008271	putative PBP binding loops; other site
457570008272	ABC-ATPase subunit interface; other site
457570008273	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570008274	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
457570008275	peptide binding site [polypeptide binding]; other site
457570008276	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
457570008277	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
457570008278	Zn2+ binding site [ion binding]; other site
457570008279	Mg2+ binding site [ion binding]; other site
457570008280	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
457570008281	Predicted membrane protein [Function unknown]; Region: COG3601
457570008282	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
457570008283	manganese transport transcriptional regulator; Provisional; Region: PRK03902
457570008284	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
457570008285	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
457570008286	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
457570008287	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
457570008288	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
457570008289	ABC-ATPase subunit  interface; other site
457570008290	dimer interface [polypeptide binding]; other site
457570008291	putative PBP binding regions; other site
457570008292	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
457570008293	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
457570008294	intersubunit interface [polypeptide binding]; other site
457570008295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570008296	putative substrate translocation pore; other site
457570008297	D-galactonate transporter; Region: 2A0114; TIGR00893
457570008298	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
457570008299	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
457570008300	EamA-like transporter family; Region: EamA; pfam00892
457570008301	EamA-like transporter family; Region: EamA; pfam00892
457570008302	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
457570008303	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
457570008304	L-lactate permease; Region: Lactate_perm; cl00701
457570008305	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
457570008306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
457570008307	putative substrate translocation pore; other site
457570008308	D-galactonate transporter; Region: 2A0114; TIGR00893
457570008309	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
457570008310	Part of AAA domain; Region: AAA_19; pfam13245
457570008311	Family description; Region: UvrD_C_2; pfam13538
457570008312	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
457570008313	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
457570008314	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
457570008315	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
457570008316	imidazolonepropionase; Validated; Region: PRK09356
457570008317	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
457570008318	active site
457570008319	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
457570008320	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
457570008321	Formiminotransferase domain; Region: FTCD; pfam02971
457570008322	urocanate hydratase; Provisional; Region: PRK05414
457570008323	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
457570008324	active sites [active]
457570008325	tetramer interface [polypeptide binding]; other site
457570008326	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570008327	non-specific DNA binding site [nucleotide binding]; other site
457570008328	salt bridge; other site
457570008329	sequence-specific DNA binding site [nucleotide binding]; other site
457570008330	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
457570008331	Catalytic dyad [active]
457570008332	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
457570008333	active site
457570008334	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
457570008335	EamA-like transporter family; Region: EamA; pfam00892
457570008336	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
457570008337	EamA-like transporter family; Region: EamA; cl17759
457570008338	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
457570008339	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
457570008340	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
457570008341	Protein export membrane protein; Region: SecD_SecF; cl14618
457570008342	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
457570008343	Transposase; Region: HTH_Tnp_1; pfam01527
457570008344	Helix-turn-helix domain; Region: HTH_28; pfam13518
457570008345	Winged helix-turn helix; Region: HTH_29; pfam13551
457570008346	Integrase core domain; Region: rve; pfam00665
457570008347	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
457570008348	MgtE intracellular N domain; Region: MgtE_N; smart00924
457570008349	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
457570008350	Divalent cation transporter; Region: MgtE; pfam01769
457570008351	Rod binding protein; Region: Rod-binding; cl01626
457570008352	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
457570008353	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
457570008354	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
457570008355	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
457570008356	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
457570008357	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
457570008358	rod shape-determining protein Mbl; Provisional; Region: PRK13928
457570008359	MreB and similar proteins; Region: MreB_like; cd10225
457570008360	nucleotide binding site [chemical binding]; other site
457570008361	Mg binding site [ion binding]; other site
457570008362	putative protofilament interaction site [polypeptide binding]; other site
457570008363	RodZ interaction site [polypeptide binding]; other site
457570008364	Stage III sporulation protein D; Region: SpoIIID; pfam12116
457570008365	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
457570008366	Peptidase family M23; Region: Peptidase_M23; pfam01551
457570008367	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
457570008368	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
457570008369	putative active site [active]
457570008370	putative NTP binding site [chemical binding]; other site
457570008371	putative nucleic acid binding site [nucleotide binding]; other site
457570008372	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
457570008373	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
457570008374	Stage II sporulation protein; Region: SpoIID; pfam08486
457570008375	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
457570008376	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
457570008377	hinge; other site
457570008378	active site
457570008379	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
457570008380	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
457570008381	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
457570008382	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
457570008383	gamma subunit interface [polypeptide binding]; other site
457570008384	epsilon subunit interface [polypeptide binding]; other site
457570008385	LBP interface [polypeptide binding]; other site
457570008386	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
457570008387	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
457570008388	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
457570008389	alpha subunit interaction interface [polypeptide binding]; other site
457570008390	Walker A motif; other site
457570008391	ATP binding site [chemical binding]; other site
457570008392	Walker B motif; other site
457570008393	inhibitor binding site; inhibition site
457570008394	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
457570008395	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
457570008396	core domain interface [polypeptide binding]; other site
457570008397	delta subunit interface [polypeptide binding]; other site
457570008398	epsilon subunit interface [polypeptide binding]; other site
457570008399	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
457570008400	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
457570008401	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
457570008402	beta subunit interaction interface [polypeptide binding]; other site
457570008403	Walker A motif; other site
457570008404	ATP binding site [chemical binding]; other site
457570008405	Walker B motif; other site
457570008406	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
457570008407	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
457570008408	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
457570008409	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
457570008410	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
457570008411	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
457570008412	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
457570008413	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
457570008414	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
457570008415	ATP synthase I chain; Region: ATP_synt_I; pfam03899
457570008416	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
457570008417	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
457570008418	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
457570008419	putative L-serine binding site [chemical binding]; other site
457570008420	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
457570008421	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
457570008422	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
457570008423	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
457570008424	active site
457570008425	homodimer interface [polypeptide binding]; other site
457570008426	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
457570008427	catalytic motif [active]
457570008428	Zn binding site [ion binding]; other site
457570008429	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
457570008430	active site
457570008431	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
457570008432	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
457570008433	dimer interface [polypeptide binding]; other site
457570008434	active site
457570008435	glycine-pyridoxal phosphate binding site [chemical binding]; other site
457570008436	folate binding site [chemical binding]; other site
457570008437	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
457570008438	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
457570008439	HAMP domain; Region: HAMP; pfam00672
457570008440	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
457570008441	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570008442	dimer interface [polypeptide binding]; other site
457570008443	putative CheW interface [polypeptide binding]; other site
457570008444	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
457570008445	dimer interface [polypeptide binding]; other site
457570008446	Cache domain; Region: Cache_1; pfam02743
457570008447	Low molecular weight phosphatase family; Region: LMWPc; cd00115
457570008448	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
457570008449	active site
457570008450	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
457570008451	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
457570008452	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
457570008453	AIR carboxylase; Region: AIRC; smart01001
457570008454	Protein of unknown function DUF111; Region: DUF111; pfam01969
457570008455	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
457570008456	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
457570008457	Ligand Binding Site [chemical binding]; other site
457570008458	YibE/F-like protein; Region: YibE_F; pfam07907
457570008459	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
457570008460	metal binding site 2 [ion binding]; metal-binding site
457570008461	putative DNA binding helix; other site
457570008462	metal binding site 1 [ion binding]; metal-binding site
457570008463	dimer interface [polypeptide binding]; other site
457570008464	structural Zn2+ binding site [ion binding]; other site
457570008465	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
457570008466	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
457570008467	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
457570008468	PhoU domain; Region: PhoU; pfam01895
457570008469	PhoU domain; Region: PhoU; pfam01895
457570008470	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775
457570008471	sporulation sigma factor SigG; Reviewed; Region: PRK08215
457570008472	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
457570008473	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
457570008474	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
457570008475	DNA binding residues [nucleotide binding]
457570008476	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
457570008477	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
457570008478	S-adenosylmethionine binding site [chemical binding]; other site
457570008479	peptide chain release factor 1; Validated; Region: prfA; PRK00591
457570008480	This domain is found in peptide chain release factors; Region: PCRF; smart00937
457570008481	RF-1 domain; Region: RF-1; pfam00472
457570008482	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
457570008483	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
457570008484	transcription termination factor Rho; Provisional; Region: rho; PRK09376
457570008485	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
457570008486	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
457570008487	RNA binding site [nucleotide binding]; other site
457570008488	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
457570008489	multimer interface [polypeptide binding]; other site
457570008490	Walker A motif; other site
457570008491	ATP binding site [chemical binding]; other site
457570008492	Walker B motif; other site
457570008493	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
457570008494	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
457570008495	putative active site [active]
457570008496	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
457570008497	active site
457570008498	intersubunit interactions; other site
457570008499	catalytic residue [active]
457570008500	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
457570008501	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
457570008502	intersubunit interface [polypeptide binding]; other site
457570008503	active site
457570008504	zinc binding site [ion binding]; other site
457570008505	Na+ binding site [ion binding]; other site
457570008506	Response regulator receiver domain; Region: Response_reg; pfam00072
457570008507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570008508	active site
457570008509	phosphorylation site [posttranslational modification]
457570008510	intermolecular recognition site; other site
457570008511	dimerization interface [polypeptide binding]; other site
457570008512	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
457570008513	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
457570008514	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
457570008515	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
457570008516	4Fe-4S binding domain; Region: Fer4; cl02805
457570008517	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
457570008518	Transglycosylase; Region: Transgly; pfam00912
457570008519	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
457570008520	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
457570008521	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
457570008522	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
457570008523	FeS/SAM binding site; other site
457570008524	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
457570008525	CTP synthetase; Validated; Region: pyrG; PRK05380
457570008526	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
457570008527	Catalytic site [active]
457570008528	active site
457570008529	UTP binding site [chemical binding]; other site
457570008530	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
457570008531	active site
457570008532	putative oxyanion hole; other site
457570008533	catalytic triad [active]
457570008534	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
457570008535	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
457570008536	Walker A/P-loop; other site
457570008537	ATP binding site [chemical binding]; other site
457570008538	Q-loop/lid; other site
457570008539	ABC transporter signature motif; other site
457570008540	Walker B; other site
457570008541	D-loop; other site
457570008542	H-loop/switch region; other site
457570008543	TOBE domain; Region: TOBE_2; pfam08402
457570008544	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
457570008545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570008546	dimer interface [polypeptide binding]; other site
457570008547	conserved gate region; other site
457570008548	putative PBP binding loops; other site
457570008549	ABC-ATPase subunit interface; other site
457570008550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
457570008551	dimer interface [polypeptide binding]; other site
457570008552	conserved gate region; other site
457570008553	putative PBP binding loops; other site
457570008554	ABC-ATPase subunit interface; other site
457570008555	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
457570008556	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
457570008557	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
457570008558	homodimer interface [polypeptide binding]; other site
457570008559	homotetramer interface [polypeptide binding]; other site
457570008560	active site pocket [active]
457570008561	cleavage site
457570008562	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
457570008563	DsrE/DsrF-like family; Region: DrsE; pfam02635
457570008564	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
457570008565	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
457570008566	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
457570008567	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
457570008568	protein binding site [polypeptide binding]; other site
457570008569	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
457570008570	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
457570008571	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
457570008572	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
457570008573	catalytic core [active]
457570008574	Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739
457570008575	Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918
457570008576	YycH protein; Region: YycI; cl02015
457570008577	YycH protein; Region: YycH; pfam07435
457570008578	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
457570008579	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
457570008580	dimerization interface [polypeptide binding]; other site
457570008581	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
457570008582	putative active site [active]
457570008583	heme pocket [chemical binding]; other site
457570008584	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
457570008585	dimer interface [polypeptide binding]; other site
457570008586	phosphorylation site [posttranslational modification]
457570008587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
457570008588	ATP binding site [chemical binding]; other site
457570008589	Mg2+ binding site [ion binding]; other site
457570008590	G-X-G motif; other site
457570008591	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
457570008592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
457570008593	active site
457570008594	phosphorylation site [posttranslational modification]
457570008595	intermolecular recognition site; other site
457570008596	dimerization interface [polypeptide binding]; other site
457570008597	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
457570008598	DNA binding site [nucleotide binding]
457570008599	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
457570008600	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
457570008601	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
457570008602	G5 domain; Region: G5; pfam07501
457570008603	Peptidase family M23; Region: Peptidase_M23; pfam01551
457570008604	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
457570008605	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
457570008606	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
457570008607	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
457570008608	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
457570008609	GDP-binding site [chemical binding]; other site
457570008610	ACT binding site; other site
457570008611	IMP binding site; other site
457570008612	replicative DNA helicase; Region: DnaB; TIGR00665
457570008613	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
457570008614	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
457570008615	Walker A motif; other site
457570008616	ATP binding site [chemical binding]; other site
457570008617	Walker B motif; other site
457570008618	DNA binding loops [nucleotide binding]
457570008619	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
457570008620	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
457570008621	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
457570008622	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
457570008623	MazG-like family; Region: MazG-like; pfam12643
457570008624	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
457570008625	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
457570008626	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
457570008627	dimer interface [polypeptide binding]; other site
457570008628	ssDNA binding site [nucleotide binding]; other site
457570008629	tetramer (dimer of dimers) interface [polypeptide binding]; other site
457570008630	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
457570008631	GTP-binding protein YchF; Reviewed; Region: PRK09601
457570008632	YchF GTPase; Region: YchF; cd01900
457570008633	G1 box; other site
457570008634	GTP/Mg2+ binding site [chemical binding]; other site
457570008635	Switch I region; other site
457570008636	G2 box; other site
457570008637	Switch II region; other site
457570008638	G3 box; other site
457570008639	G4 box; other site
457570008640	G5 box; other site
457570008641	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
457570008642	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
457570008643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
457570008644	TPR motif; other site
457570008645	Tetratricopeptide repeat; Region: TPR_12; pfam13424
457570008646	binding surface
457570008647	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
457570008648	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
457570008649	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
457570008650	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
457570008651	Peptidase family M23; Region: Peptidase_M23; pfam01551
457570008652	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
457570008653	ParB-like nuclease domain; Region: ParB; smart00470
457570008654	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
457570008655	non-specific DNA binding site [nucleotide binding]; other site
457570008656	salt bridge; other site
457570008657	sequence-specific DNA binding site [nucleotide binding]; other site
457570008658	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
457570008659	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
457570008660	P-loop; other site
457570008661	Magnesium ion binding site [ion binding]; other site
457570008662	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
457570008663	Magnesium ion binding site [ion binding]; other site
457570008664	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
457570008665	ParB-like nuclease domain; Region: ParB; smart00470
457570008666	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
457570008667	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
457570008668	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
457570008669	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
457570008670	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
457570008671	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
457570008672	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
457570008673	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
457570008674	GTP/Mg2+ binding site [chemical binding]; other site
457570008675	G5 box; other site
457570008676	trmE is a tRNA modification GTPase; Region: trmE; cd04164
457570008677	G1 box; other site
457570008678	G1 box; other site
457570008679	GTP/Mg2+ binding site [chemical binding]; other site
457570008680	Switch I region; other site
457570008681	Switch I region; other site
457570008682	G2 box; other site
457570008683	G2 box; other site
457570008684	Switch II region; other site
457570008685	G3 box; other site
457570008686	G3 box; other site
457570008687	Switch II region; other site
457570008688	G4 box; other site
457570008689	G5 box; other site
457570008690	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
457570008691	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
457570008692	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
457570008693	G-X-X-G motif; other site
457570008694	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
457570008695	RxxxH motif; other site
457570008696	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
457570008697	Haemolytic domain; Region: Haemolytic; pfam01809
457570008698	ribonuclease P; Reviewed; Region: rnpA; PRK00499
457570008699	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
457570008700	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
457570008701	Integrase; Region: Integrase_1; pfam12835
457570008702	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
457570008703	active site
457570008704	Helix-turn-helix domain; Region: HTH_17; pfam12728
457570008705	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
457570008706	active site
457570008707	DNA binding site [nucleotide binding]
457570008708	Int/Topo IB signature motif; other site
457570008709	RRXRR protein; Region: RRXRR; pfam14239
457570008710	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
457570008711	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
457570008712	active site
457570008713	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
457570008714	non-specific DNA interactions [nucleotide binding]; other site
457570008715	DNA binding site [nucleotide binding]
457570008716	sequence specific DNA binding site [nucleotide binding]; other site
457570008717	putative cAMP binding site [chemical binding]; other site
457570008718	PemK-like protein; Region: PemK; pfam02452