-- dump date   	20140619_163148
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_001598185.1	Code: KR; COG: COG0454
YP_001598187.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_001598188.1	Code: S; COG: COG1434
YP_001598189.1	Code: P; COG: COG1393
YP_001598190.1	Code: OC; COG: COG0526
YP_001598191.1	Code: D; COG: COG2884
YP_001598192.1	Code: D; COG: COG2177
YP_001598193.1	Code: K; COG: COG5007
YP_001598194.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_001598195.1	Code: L; COG: COG2826
YP_001598196.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_001598197.1	Code: P; COG: COG0861
YP_001598198.1	Code: S; COG: COG3399
YP_001598199.1	catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A
YP_001598200.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_001598203.1	zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_001598206.1	Code: NU; COG: COG4969
YP_001598207.1	Code: NU; COG: COG4969
YP_001598209.1	Code: NU; COG: COG4969
YP_001598211.1	Code: O; COG: COG0545
YP_001598212.1	Code: S; COG: COG3205
YP_001598213.1	Code: CHR; COG: COG1052
YP_001598214.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_001598215.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_001598217.1	Code: M; COG: COG2821
YP_001598218.1	Code: P; COG: COG0672
YP_001598219.1	Code: P; COG: COG2822
YP_001598220.1	Code: P; COG: COG2837
YP_001598221.1	Code: P; COG: COG2824
YP_001598222.1	Code: M; COG: COG1207
YP_001598224.1	Code: R; COG: COG1011
YP_001598225.1	Code: H; COG: COG4143
YP_001598226.1	Code: M; COG: COG0668
YP_001598227.1	Code: R; COG: COG1546
YP_001598229.1	Code: U; COG: COG0552
YP_001598230.1	Code: L; COG: COG2827
YP_001598232.1	Code: NU; COG: COG3419
YP_001598233.1	Code: S; COG: COG1289
YP_001598234.1	Code: NU; COG: COG5008
YP_001598235.1	Code: NU; COG: COG2805
YP_001598236.1	Code: R; COG: COG0325
YP_001598238.1	Code: E; COG: COG0345
YP_001598239.1	Code: T; COG: COG1734
YP_001598241.1	Code: L; COG: COG1555
YP_001598244.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_001598245.1	Code: S; COG: COG1297
YP_001598246.1	Code: M; COG: COG1898
YP_001598247.1	Code: M; COG: COG1209
YP_001598248.1	Code: M; COG: COG1088
YP_001598249.1	Code: M; COG: COG1087
YP_001598253.1	Code: M; COG: COG2089
YP_001598254.1	Code: M; COG: COG1083
YP_001598255.1	Code: M; COG: COG0381
YP_001598256.1	Code: M; COG: COG1596
YP_001598257.1	Code: M; COG: COG3524
YP_001598258.1	Code: GM; COG: COG1682
YP_001598259.1	Code: GM; COG: COG1134
YP_001598260.1	Code: K; COG: COG2183
YP_001598262.1	Code: M; COG: COG1087
YP_001598263.1	Code: M; COG: COG1088
YP_001598264.1	Code: M; COG: COG1209
YP_001598265.1	Code: M; COG: COG1898
YP_001598266.1	Code: M; COG: COG3563
YP_001598267.1	Code: M; COG: COG3562
YP_001598268.1	Code: R; COG: COG0790
YP_001598269.1	Code: E; COG: COG0786
YP_001598273.1	Code: I; COG: COG2067
YP_001598274.1	Code: G; COG: COG0469
YP_001598275.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_001598277.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_001598278.1	Code: L; COG: COG0708
YP_001598280.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_001598281.1	Code: S; COG: COG1714
YP_001598282.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_001598283.1	Code: M; COG: COG2870
YP_001598284.1	activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins and catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP
YP_001598286.1	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_001598287.1	Code: H; COG: COG2104
YP_001598288.1	Code: H; COG: COG0352
YP_001598289.1	Code: E; COG: COG0665
YP_001598290.1	Code: F; COG: COG1457
YP_001598291.1	Code: R; COG: COG0312
YP_001598294.1	Code: R; COG: COG2056
YP_001598295.1	Code: S; COG: COG2900
YP_001598296.1	Code: H; COG: COG0476
YP_001598297.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_001598298.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_001598300.1	Code: S; COG: COG3027
YP_001598301.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_001598302.1	forms a direct contact with the tRNA during translation
YP_001598303.1	Code: K; COG: COG0583
YP_001598304.1	Code: S; COG: COG0327
YP_001598305.1	Code: C; COG: COG0723
YP_001598306.1	Code: C; COG: COG1290
YP_001598307.1	Code: C; COG: COG2857
YP_001598308.1	Code: S; COG: COG1322
YP_001598309.1	Code: R; COG: COG0491
YP_001598310.1	catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA
YP_001598311.1	Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively
YP_001598312.1	Code: G; COG: COG2893
YP_001598313.1	Code: G; COG: COG1925
YP_001598314.1	Code: G; COG: COG1080
YP_001598316.1	Code: E; COG: COG3842
YP_001598317.1	Code: LR; COG: COG0494
YP_001598318.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_001598319.1	Code: L; COG: COG3547
YP_001598327.1	Code: L; COG: COG2946
YP_001598329.1	Code: M; COG: COG3203
YP_001598330.1	Code: T; COG: COG2337
YP_001598331.1	Code: T; COG: COG2336
YP_001598332.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_001598334.1	Code: R; COG: COG1451
YP_001598335.1	Code: I; COG: COG0204
YP_001598336.1	Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate
YP_001598337.1	Code: E; COG: COG0814
YP_001598338.1	Involved in ubiquinone biosynthesis
YP_001598339.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine
YP_001598340.1	Code: G; COG: COG3265
YP_001598341.1	Code: GE; COG: COG2610
YP_001598342.1	Code: P; COG: COG1178
YP_001598343.1	Code: P; COG: COG0288
YP_001598344.1	Code: H; COG: COG1057
YP_001598345.1	Code: S; COG: COG0799
YP_001598346.2	SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_001598347.1	Code: CO; COG: COG2924
YP_001598348.1	Code: R; COG: COG0670
YP_001598349.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_001598350.1	Code: J; COG: COG0564
YP_001598351.1	Code: L; COG: COG1555
YP_001598352.1	Code: NU; COG: COG4968
YP_001598356.1	Code: E; COG: COG2856
YP_001598357.1	Code: L; COG: COG1643
YP_001598358.1	Code: R; COG: COG2194
YP_001598360.1	Code: L; COG: COG1643
YP_001598361.1	Code: P; COG: COG0038
YP_001598362.1	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate
YP_001598363.1	Code: M; COG: COG1346
YP_001598364.1	Code: R; COG: COG1380
YP_001598367.1	Code: M; COG: COG0791
YP_001598368.1	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_001598369.1	Code: P; COG: COG2239
YP_001598370.1	Code: R; COG: COG0491
YP_001598371.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_001598372.1	Code: E; COG: COG0347
YP_001598373.1	Code: P; COG: COG4604
YP_001598375.1	Code: P; COG: COG4605
YP_001598376.1	Code: P; COG: COG4606
YP_001598377.1	Code: P; COG: COG4607
YP_001598378.1	Code: P; COG: COG1629
YP_001598382.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_001598384.1	Code: S; COG: COG5346
YP_001598385.1	Code: MU; COG: COG3468
YP_001598391.1	Code: L; COG: COG3039
YP_001598393.1	Code: L; COG: COG0749
YP_001598394.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_001598396.1	Code: S; COG: COG2855
YP_001598397.1	defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly
YP_001598399.1	Code: E; COG: COG0019
YP_001598401.1	Code: L; COG: COG3676
YP_001598402.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_001598403.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_001598405.1	Code: EH; COG: COG0147
YP_001598407.1	NAD-linked
YP_001598410.1	Code: K; COG: COG2207
YP_001598411.1	Code: Q; COG: COG1127
YP_001598412.1	Code: Q; COG: COG0767
YP_001598413.1	Code: Q; COG: COG1463
YP_001598414.1	Code: Q; COG: COG2854
YP_001598415.1	Code: R; COG: COG3113
YP_001598416.1	Code: M; COG: COG2853
YP_001598418.1	Code: R; COG: COG0824
YP_001598419.1	Code: OC; COG: COG0526
YP_001598421.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_001598422.1	Code: P; COG: COG4300
YP_001598423.1	Code: M; COG: COG1807
YP_001598424.1	Code: O; COG: COG0625
YP_001598425.1	Code: R; COG: COG2969
YP_001598427.1	Code: S; COG: COG1610
YP_001598428.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_001598429.1	Code: M; COG: COG0741
YP_001598431.1	Code: P; COG: COG1135
YP_001598432.1	Code: P; COG: COG2011
YP_001598433.1	Code: P; COG: COG1464
YP_001598434.1	Code: H; COG: COG0163
YP_001598435.1	Code: K; COG: COG1475
YP_001598437.1	Code: L; COG: COG2826
YP_001598439.1	Code: C; COG: COG3312
YP_001598440.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_001598441.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_001598442.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_001598443.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_001598444.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_001598445.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_001598446.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_001598447.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_001598448.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_001598449.1	Code: S; COG: COG3171
YP_001598450.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_001598451.1	Code: M; COG: COG0463
YP_001598452.1	Code: M; COG: COG3306
YP_001598454.1	Code: M; COG: COG3306
YP_001598455.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_001598456.1	Code: G; COG: COG0483
YP_001598457.1	Code: S; COG: COG3012
YP_001598458.1	Code: L; COG: COG3039
YP_001598459.1	Code: L; COG: COG1943
YP_001598460.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_001598461.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_001598462.1	Code: V; COG: COG1132
YP_001598463.1	Code: I; COG: COG0331
YP_001598464.1	Code: S; COG: COG3326
YP_001598465.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_001598469.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_001598470.1	Code: R; COG: COG2236
YP_001598471.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_001598472.1	Code: R; COG: COG1399
YP_001598473.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_001598474.1	Code: R; COG: COG0313
YP_001598475.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_001598476.1	Code: S; COG: COG0759
YP_001598477.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_001598478.1	Code: J; COG: COG0230
YP_001598479.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_001598480.1	binds the polymerase to DNA and acts as a sliding clamp
YP_001598481.1	Code: L; COG: COG3676
YP_001598482.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_001598484.1	Code: J; COG: COG2913
YP_001598485.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_001598487.1	Code: L; COG: COG0338
YP_001598489.1	Code: O; COG: COG0501
YP_001598491.1	Code: K; COG: COG2944
YP_001598492.1	Code: S; COG: COG4737
YP_001598494.1	Code: U; COG: COG1314
YP_001598495.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_001598496.1	Code: T; COG: COG1956
YP_001598497.1	Code: O; COG: COG2518
YP_001598498.1	Code: P; COG: COG0607
YP_001598500.1	Code: P; COG: COG4773
YP_001598501.1	Code: G; COG: COG0662
YP_001598503.1	Code: P; COG: COG4607
YP_001598504.1	Code: K; COG: COG2207
YP_001598505.1	Code: E; COG: COG1505
YP_001598506.1	catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis
YP_001598508.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_001598509.1	Code: L; COG: COG1573
YP_001598510.1	Code: R; COG: COG0456
YP_001598511.1	Code: O; COG: COG1214
YP_001598513.1	class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis
YP_001598514.1	Code: L; COG: COG4973
YP_001598515.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_001598516.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_001598518.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_001598519.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_001598520.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_001598521.1	Code: I; COG: COG0439
YP_001598522.1	composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_001598524.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_001598526.1	Code: R; COG: COG2249
YP_001598527.1	Code: K; COG: COG0583
YP_001598528.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_001598530.1	Code: R; COG: COG1040
YP_001598531.1	Code: S; COG: COG2852
YP_001598533.1	Code: E; COG: COG0346
YP_001598534.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_001598536.1	Code: NU; COG: COG3419
YP_001598537.1	Code: D; COG: COG0489
YP_001598538.1	Code: OC; COG: COG0526
YP_001598539.1	Code: K; COG: COG1846
YP_001598540.1	Code: R; COG: COG1853
YP_001598541.1	Code: MJ; COG: COG1208
YP_001598542.1	Code: S; COG: COG2510
YP_001598543.1	catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate
YP_001598544.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_001598546.1	Code: I; COG: COG1835
YP_001598547.1	Code: J; COG: COG0162
YP_001598548.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_001598549.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme
YP_001598550.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_001598551.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_001598552.1	Code: R; COG: COG0546
YP_001598553.1	Code: L; COG: COG3039
YP_001598554.1	Code: S; COG: COG3512
YP_001598557.1	Code: S; COG: COG3513
YP_001598558.1	Code: L; COG: COG0587
YP_001598559.1	Code: S; COG: COG2501
YP_001598561.1	Code: R; COG: COG0613
YP_001598562.1	transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis
YP_001598563.1	Code: MG; COG: COG1086
YP_001598564.1	Code: M; COG: COG0399
YP_001598566.1	undetermined role; proteins in this cluster present a single carB domain while active CarB proteins (involved in the production of carbamoyl phosphate) present two domains
YP_001598569.1	Code: R; COG: COG2244
YP_001598570.1	Code: H; COG: COG1985
YP_001598571.1	Code: K; COG: COG1327
YP_001598572.1	Code: R; COG: COG0121
YP_001598573.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_001598574.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_001598575.1	Code: U; COG: COG4796
YP_001598576.1	Code: NU; COG: COG3168
YP_001598577.1	Code: NU; COG: COG3167
YP_001598578.1	Code: NU; COG: COG3166
YP_001598579.1	Code: NU; COG: COG4972
YP_001598580.1	Code: M; COG: COG5009
YP_001598581.1	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_001598582.1	Code: C; COG: COG2863
YP_001598583.1	Code: O; COG: COG1333
YP_001598584.1	Code: O; COG: COG0755
YP_001598585.1	Code: O; COG: COG0533
YP_001598586.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_001598587.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_001598588.1	Code: L; COG: COG3676
YP_001598589.1	Code: L; COG: COG3676
YP_001598590.1	Code: M; COG: COG2027
YP_001598591.1	Code: R; COG: COG0431
YP_001598592.1	Code: C; COG: COG2851
YP_001598593.1	Code: T; COG: COG0642
YP_001598594.1	Code: J; COG: COG1530
YP_001598595.1	Code: O; COG: COG0695
YP_001598596.1	molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA
YP_001598597.1	catalyzes branch migration in Holliday junction intermediates
YP_001598598.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_001598602.1	Code: S; COG: COG2850
YP_001598605.1	Code: U; COG: COG2831
YP_001598607.1	Code: U; COG: COG3210
YP_001598610.1	Code: U; COG: COG3210
YP_001598612.1	Code: S; COG: COG3792
YP_001598617.1	RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; this protein contains a C-terminal extension of unknown function
YP_001598618.1	Code: R; COG: COG0603
YP_001598620.1	Code: H; COG: COG0720
YP_001598621.1	Code: S; COG: COG3759
YP_001598622.1	Code: O; COG: COG0602
YP_001598623.1	hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
YP_001598624.1	Code: C; COG: COG1757
YP_001598626.1	Code: O; COG: COG0265
YP_001598627.1	Code: L; COG: COG0177
YP_001598628.1	Code: S; COG: COG1238
YP_001598630.1	Code: G; COG: COG0738
YP_001598631.1	Code: C; COG: COG1757
YP_001598632.1	Code: P; COG: COG4535
YP_001598633.1	Code: R; COG: COG0319
YP_001598634.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_001598636.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_001598638.1	Code: S; COG: COG4391
YP_001598639.1	Code: C; COG: COG1620
YP_001598640.1	catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine
YP_001598641.1	Code: D; COG: COG1196
YP_001598643.1	similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs
YP_001598644.1	Code: NU; COG: COG4968
YP_001598645.1	Code: M; COG: COG0845
YP_001598646.1	Code: V; COG: COG0577
YP_001598647.1	Code: O; COG: COG1651
YP_001598648.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_001598649.1	Code: L; COG: COG3547
YP_001598650.1	Code: L; COG: COG3039
YP_001598651.1	Code: L; COG: COG3039
YP_001598654.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_001598656.1	Code: K; COG: COG2932
YP_001598657.1	Code: S; COG: COG0316
YP_001598659.1	an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions
YP_001598660.1	Code: E; COG: COG1045
YP_001598661.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_001598662.1	Code: S; COG: COG2991
YP_001598663.1	Code: H; COG: COG1477
YP_001598664.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_001598665.1	Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
YP_001598666.1	Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm
YP_001598667.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_001598668.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_001598669.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_001598670.1	Code: P; COG: COG1055
YP_001598671.1	Code: S; COG: COG2832
YP_001598672.1	Code: S; COG: COG3310
YP_001598673.1	Code: K; COG: COG1522
YP_001598674.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_001598675.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_001598676.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_001598678.1	Code: V; COG: COG1131
YP_001598679.1	Code: C; COG: COG4314
YP_001598680.1	Code: C; COG: COG0644
YP_001598681.1	Code: R; COG: COG3271
YP_001598682.1	Code: L; COG: COG3676
YP_001598684.1	Code: Q; COG: COG2931
YP_001598685.1	Code: P; COG: COG0803
YP_001598686.1	Code: P; COG: COG1108
YP_001598687.1	Code: P; COG: COG1121
YP_001598688.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_001598689.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_001598690.1	Essential for efficient processing of 16S rRNA
YP_001598691.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_001598692.1	Code: C; COG: COG1042
YP_001598693.1	Code: T; COG: COG0642
YP_001598694.1	Code: TK; COG: COG0745
YP_001598695.1	Code: M; COG: COG3307
YP_001598696.1	Code: S; COG: COG3308
YP_001598697.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_001598698.1	Code: U; COG: COG0805
YP_001598699.1	Code: U; COG: COG1826
YP_001598700.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_001598701.1	Code: FGR; COG: COG0537
YP_001598702.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis
YP_001598703.1	Code: ER; COG: COG1063
YP_001598704.1	Code: BQ; COG: COG0123
YP_001598705.1	Code: U; COG: COG1862
YP_001598706.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_001598707.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_001598709.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_001598710.1	Code: E; COG: COG3842
YP_001598711.1	Code: E; COG: COG1177
YP_001598712.1	Code: E; COG: COG0665
YP_001598713.1	Code: P; COG: COG0004
YP_001598716.1	Code: L; COG: COG3676
YP_001598717.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_001598718.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_001598719.1	Code: S; COG: COG1806
YP_001598720.1	Code: R; COG: COG0546
YP_001598721.1	Code: S; COG: COG2833
YP_001598722.1	Code: M; COG: COG2834
YP_001598723.1	Code: E; COG: COG0687
YP_001598724.1	Code: M; COG: COG0463
YP_001598725.1	Code: R; COG: COG0663
YP_001598726.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_001598727.1	PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers
YP_001598728.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_001598729.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_001598730.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_001598732.1	Code: E; COG: COG3842
YP_001598733.1	Code: P; COG: COG1178
YP_001598734.1	Code: P; COG: COG1840
YP_001598737.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_001598738.1	Code: M; COG: COG1210
YP_001598739.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_001598741.1	Code: C; COG: COG0221
YP_001598742.1	converts dATP to dAMP and pyrophosphate
YP_001598745.1	Code: K; COG: COG2732
YP_001598765.1	Code: P; COG: COG0168
YP_001598766.1	hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP
YP_001598767.1	Code: J; COG: COG0251
YP_001598768.1	Code: M; COG: COG3637
YP_001598769.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_001598770.1	Code: L; COG: COG0272
YP_001598772.1	Code: V; COG: COG3023
YP_001598773.1	Code: R; COG: COG1559
YP_001598774.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_001598775.1	Code: C; COG: COG0281
YP_001598777.1	transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate
YP_001598778.1	Code: S; COG: COG3184
YP_001598779.1	Code: S; COG: COG2835
YP_001598780.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_001598784.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_001598785.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_001598787.1	Code: O; COG: COG0425
YP_001598789.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_001598790.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_001598791.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_001598792.1	Code: S; COG: COG4859
YP_001598793.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_001598794.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_001598796.1	catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis
YP_001598797.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_001598798.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_001598800.1	Code: R; COG: COG1286
YP_001598802.1	Code: H; COG: COG0285
YP_001598805.1	Code: E; COG: COG1126
YP_001598806.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_001598807.1	Code: L; COG: COG3663
YP_001598808.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_001598809.1	Code: MU; COG: COG3468
YP_001598811.1	Code: R; COG: COG4105
YP_001598812.1	Code: J; COG: COG0564
YP_001598813.1	Code: R; COG: COG0385
YP_001598815.1	Code: S; COG: COG1496
YP_001598816.1	Code: M; COG: COG2980
YP_001598817.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_001598819.1	Code: S; COG: COG1714
YP_001598820.1	Code: S; COG: COG1561
YP_001598821.1	binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters
YP_001598822.1	Transfers the fatty acyl group on membrane lipoproteins
YP_001598823.1	Code: S; COG: COG2354
YP_001598826.1	Code: C; COG: COG2010
YP_001598827.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_001598828.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_001598829.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_001598830.1	Code: J; COG: COG0290
YP_001598831.1	Code: J; COG: COG0291
YP_001598832.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_001598833.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_001598836.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_001598837.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_001598839.1	F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein
YP_001598841.1	Code: H; COG: COG0161
YP_001598842.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_001598843.1	Code: H; COG: COG3161
YP_001598844.1	catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway
YP_001598845.1	Code: GT; COG: COG1762
YP_001598846.1	catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system
YP_001598847.1	Code: R; COG: COG1660
YP_001598848.1	essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc)
YP_001598849.1	Code: K; COG: COG1386
YP_001598850.1	Code: L; COG: COG0497
YP_001598852.1	Code: E; COG: COG0665
YP_001598853.1	Code: S; COG: COG3536
YP_001598854.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_001598855.1	Code: R; COG: COG3467
YP_001598856.1	Code: H; COG: COG0801
YP_001598857.1	Code: S; COG: COG3094
YP_001598858.1	Code: QR; COG: COG0500
YP_001598859.1	Code: R; COG: COG1923
YP_001598860.1	Code: M; COG: COG1686
YP_001598861.1	Code: O; COG: COG1225
YP_001598862.1	Code: L; COG: COG4974
YP_001598863.1	Code: P; COG: COG2906
YP_001598864.1	Code: OC; COG: COG0526
YP_001598867.1	Code: M; COG: COG1091
YP_001598868.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_001598869.1	Code: J; COG: COG1185
YP_001598870.1	Code: S; COG: COG2836
YP_001598872.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_001598874.1	Code: E; COG: COG0031
YP_001598875.1	Code: GER; COG: COG0697
YP_001598876.1	Code: U; COG: COG0681
YP_001598877.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_001598878.1	Code: F; COG: COG0775
YP_001598879.1	Code: NU; COG: COG5008
YP_001598880.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_001598881.1	Code: NU; COG: COG3215
YP_001598882.1	Code: L; COG: COG0084
YP_001598883.1	Code: O; COG: COG0278
YP_001598885.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_001598886.1	Code: S; COG: COG4390
YP_001598888.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis
YP_001598889.1	Code: H; COG: COG2959
YP_001598890.1	Code: H; COG: COG3071
YP_001598891.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_001598894.1	Code: L; COG: COG0270
YP_001598895.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_001598896.1	Code: S; COG: COG3439
YP_001598897.1	Code: P; COG: COG0607
YP_001598898.1	Code: L; COG: COG1074
YP_001598899.1	Code: P; COG: COG2837
YP_001598900.1	Code: ET; COG: COG0834
YP_001598901.1	Code: E; COG: COG0765
YP_001598902.1	Code: E; COG: COG1126
YP_001598903.1	Code: G; COG: COG1109
YP_001598904.1	Code: O; COG: COG0652
YP_001598905.1	Code: P; COG: COG0471
YP_001598906.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_001598907.1	Code: S; COG: COG2914
YP_001598908.1	Code: I; COG: COG2867
YP_001598909.1	Code: O; COG: COG0465
YP_001598910.1	Code: J; COG: COG0293
YP_001598911.1	Code: J; COG: COG1534
YP_001598912.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_001598913.1	Code: E; COG: COG0626
YP_001598914.1	similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis
YP_001598916.1	Code: C; COG: COG0778
YP_001598917.1	Code: J; COG: COG1187
YP_001598918.1	catalyzes the phosphorylation of NAD to NADP
YP_001598919.1	Code: S; COG: COG3165
YP_001598920.1	Code: MG; COG: COG0451
YP_001598921.1	Code: K; COG: COG1309
YP_001598922.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_001598923.1	Code: L; COG: COG3676
YP_001598924.1	NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones
YP_001598925.1	May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
YP_001598926.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_001598930.1	putative metalloprotease
YP_001598931.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_001598932.1	type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_001598933.1	Code: M; COG: COG2870
YP_001598934.1	Code: L; COG: COG0270
YP_001598935.1	Code: V; COG: COG3440
YP_001598936.1	Code: MG; COG: COG0451
YP_001598937.1	Code: R; COG: COG3943
YP_001598938.1	Code: V; COG: COG0732
YP_001598939.1	Code: O; COG: COG0542
YP_001598940.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_001598941.1	Code: K; COG: COG1278
YP_001598942.1	Code: R; COG: COG0312
YP_001598943.1	Code: S; COG: COG3028
YP_001598945.1	Code: L; COG: COG0608
YP_001598946.1	Code: L; COG: COG2826
YP_001598947.1	Code: J; COG: COG0617
YP_001598949.1	Code: T; COG: COG1702
YP_001598951.1	Code: S; COG: COG3471
YP_001598952.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_001598953.1	Code: S; COG: COG4642
YP_001598954.1	Required for efficient pilin antigenic variation
YP_001598955.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_001598956.1	Code: S; COG: COG2976
YP_001598957.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_001598958.1	Code: R; COG: COG3271
YP_001598969.1	Code: J; COG: COG0564
YP_001598970.1	Code: R; COG: COG2945
YP_001598971.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_001598972.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_001598973.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_001598974.1	Code: R; COG: COG0457
YP_001598975.1	Incorporates lipoproteins in the outer membrane after they are released by the LolA protein
YP_001598976.1	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
YP_001598977.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_001598978.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_001598979.1	Code: M; COG: COG1686
YP_001598980.1	threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_001598981.1	Code: P; COG: COG1118
YP_001598982.1	Code: P; COG: COG4208
YP_001598983.1	Code: O; COG: COG0555
YP_001598985.1	Code: S; COG: COG1755
YP_001598986.1	Code: P; COG: COG0605
YP_001598987.1	unwinds double stranded DNA
YP_001598988.1	Code: NU; COG: COG4970
YP_001598989.1	Code: NU; COG: COG4967
YP_001598990.1	Code: NU; COG: COG4966
YP_001598991.1	Code: NU; COG: COG4726
YP_001598992.1	Code: NU; COG: COG4969
YP_001598994.1	catalyzes the formation of dUMP from dUTP
YP_001598995.1	catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate
YP_001598996.1	Code: S; COG: COG3022
YP_001598997.1	Code: L; COG: COG3039
YP_001598999.1	Code: C; COG: COG2838
YP_001599002.1	Code: C; COG: COG3909
YP_001599003.1	Code: R; COG: COG4221
YP_001599004.1	Code: I; COG: COG1607
YP_001599008.1	Code: R; COG: COG0596
YP_001599009.1	Code: M; COG: COG3317
YP_001599010.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_001599011.1	Code: F; COG: COG2233
YP_001599012.1	Code: J; COG: COG0566
YP_001599013.1	Code: S; COG: COG2839
YP_001599014.1	Code: FJ; COG: COG0590
YP_001599015.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_001599017.1	Code: S; COG: COG4394
YP_001599018.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_001599020.1	Code: QR; COG: COG0500
YP_001599021.1	Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine
YP_001599022.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif
YP_001599023.1	RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_001599024.1	Code: E; COG: COG0685
YP_001599025.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_001599027.1	Code: O; COG: COG0678
YP_001599028.1	Catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_001599030.1	Code: C; COG: COG2009
YP_001599031.1	Code: C; COG: COG2142
YP_001599032.1	Code: C; COG: COG1053
YP_001599033.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_001599034.1	Code: S; COG: COG2938
YP_001599035.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_001599036.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_001599037.1	component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA
YP_001599038.1	E3 component of 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_001599040.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_001599041.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_001599043.1	Code: K; COG: COG2378
YP_001599044.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_001599045.1	catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine
YP_001599046.1	Code: P; COG: COG1629
YP_001599047.2	TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity
YP_001599048.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_001599050.1	Code: L; COG: COG3676
YP_001599051.1	Code: L; COG: COG2946
YP_001599058.1	Code: R; COG: COG2249
YP_001599059.1	catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme
YP_001599060.1	Code: S; COG: COG3686
YP_001599061.1	forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm
YP_001599062.1	Code: E; COG: COG0560
YP_001599063.1	Code: P; COG: COG0038
YP_001599064.1	involved in de novo purine biosynthesis
YP_001599065.1	Code: L; COG: COG3547
YP_001599067.1	Code: M; COG: COG0860
YP_001599071.1	Code: L; COG: COG3039
YP_001599072.1	Code: UW; COG: COG5295
YP_001599073.1	Code: C; COG: COG1773
YP_001599074.1	Code: I; COG: COG1960
YP_001599075.1	Code: S; COG: COG2128
YP_001599077.1	component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent
YP_001599079.1	Code: C; COG: COG0277
YP_001599080.1	Code: J; COG: COG0042
YP_001599082.1	Code: L; COG: COG3039
YP_001599089.1	Code: K; COG: COG1396
YP_001599091.1	Code: R; COG: COG3926
YP_001599095.1	Code: L; COG: COG2801
YP_001599096.1	Code: S; COG: COG2840
YP_001599098.1	Code: P; COG: COG1613
YP_001599099.1	Code: KR; COG: COG0454
YP_001599100.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_001599102.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_001599103.1	Code: R; COG: COG0488
YP_001599104.1	Code: S; COG: COG0586
YP_001599106.1	Code: L; COG: COG3039
YP_001599107.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_001599109.1	Code: E; COG: COG0405
YP_001599111.1	Code: S; COG: COG2841
YP_001599112.1	catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate
YP_001599113.1	Code: R; COG: COG2961
YP_001599114.1	Code: S; COG: COG0344
YP_001599115.1	Code: H; COG: COG1539
YP_001599116.1	Code: LR; COG: COG0494
YP_001599119.1	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_001599120.1	Code: S; COG: COG3235
YP_001599121.1	Code: D; COG: COG1674
YP_001599122.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_001599123.1	Code: E; COG: COG0263
YP_001599124.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_001599125.1	Code: R; COG: COG3318
YP_001599126.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_001599127.1	Code: E; COG: COG2866
YP_001599128.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_001599130.1	Code: E; COG: COG0560
YP_001599131.1	Code: L; COG: COG0593
YP_001599132.1	Code: R; COG: COG4178
YP_001599133.1	Code: K; COG: COG2932
YP_001599134.1	Code: L; COG: COG2801
YP_001599136.1	Code: R; COG: COG2842
YP_001599140.1	Code: R; COG: COG4396
YP_001599141.1	Code: L; COG: COG2826
YP_001599149.1	Code: S; COG: COG4382
YP_001599151.1	Code: M; COG: COG0860
YP_001599157.1	Code: S; COG: COG3422
YP_001599164.1	Code: S; COG: COG4383
YP_001599166.1	Code: R; COG: COG5005
YP_001599167.1	Code: R; COG: COG4388
YP_001599169.1	Code: S; COG: COG3778
YP_001599172.1	Code: S; COG: COG3514
YP_001599173.1	Code: S; COG: COG2929
YP_001599177.1	Code: T; COG: COG2336
YP_001599178.1	Code: T; COG: COG2337
YP_001599180.1	Code: S; COG: COG4380
YP_001599181.1	Code: S; COG: COG4259
YP_001599182.1	Code: M; COG: COG1462
YP_001599183.1	Code: IQR; COG: COG1028
YP_001599184.1	Code: R; COG: COG2907
YP_001599185.1	Code: I; COG: COG1562
YP_001599186.1	involved in the maturation of iron-sulfur cluster-containing proteins
YP_001599189.1	Code: S; COG: COG3779
YP_001599190.1	Code: C; COG: COG0633
YP_001599192.1	Code: S; COG: COG2975
YP_001599193.1	Code: J; COG: COG1188
YP_001599194.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_001599195.1	Code: D; COG: COG0037
YP_001599196.1	Code: J; COG: COG0566
YP_001599201.1	Code: M; COG: COG0773
YP_001599202.1	Code: H; COG: COG0502
YP_001599203.1	Code: M; COG: COG2843
YP_001599204.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_001599205.1	hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide
YP_001599206.1	Code: P; COG: COG0369
YP_001599207.1	Code: P; COG: COG2895
YP_001599208.1	with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_001599209.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_001599212.1	Code: C; COG: COG3658
YP_001599213.1	Code: G; COG: COG0063
YP_001599214.1	Code: T; COG: COG1217
YP_001599215.1	Code: K; COG: COG0557
YP_001599217.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_001599219.1	Code: O; COG: COG2844
YP_001599220.1	Code: K; COG: COG1396
YP_001599221.1	Code: P; COG: COG2193
YP_001599222.1	Code: P; COG: COG2193
YP_001599225.1	Code: L; COG: COG2801
YP_001599227.1	Code: L; COG: COG0270
YP_001599228.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_001599229.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_001599230.1	Code: S; COG: COG2921
YP_001599232.1	Code: R; COG: COG0628
YP_001599235.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_001599239.1	Code: R; COG: COG0488
YP_001599240.1	Code: S; COG: COG3737
YP_001599241.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_001599243.1	Code: L; COG: COG0776
YP_001599244.1	Code: O; COG: COG0466
YP_001599245.1	Code: J; COG: COG2890
YP_001599246.1	Code: L; COG: COG0507
YP_001599247.1	Code: V; COG: COG1136
YP_001599248.1	Code: M; COG: COG4591
YP_001599250.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_001599251.1	Code: O; COG: COG0760
YP_001599252.1	Code: P; COG: COG1393
YP_001599253.1	Code: R; COG: COG0488
YP_001599254.1	catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
YP_001599256.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_001599257.1	Code: G; COG: COG0036
YP_001599258.1	Code: UNTP; COG: COG3678
YP_001599259.1	Code: R; COG: COG2607
YP_001599260.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_001599261.1	Code: H; COG: COG0746
YP_001599262.1	Code: T; COG: COG3850
YP_001599263.1	Code: TK; COG: COG2197
YP_001599265.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_001599268.1	catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate
YP_001599270.2	bifunctional enzyme DHBP synthase/GTP cyclohydrolase II-like protein; functions in riboflavin synthesis
YP_001599271.1	Code: V; COG: COG0286
YP_001599273.1	Code: V; COG: COG0610
YP_001599274.1	Code: L; COG: COG2256
YP_001599277.1	Code: K; COG: COG0583
YP_001599280.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_001599282.1	Code: C; COG: COG1018
YP_001599284.1	Code: P; COG: COG2217
YP_001599285.1	Code: R; COG: COG2262
YP_001599287.1	Code: S; COG: COG1636
YP_001599288.1	Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase
YP_001599290.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_001599292.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_001599293.1	Code: L; COG: COG0270
YP_001599295.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_001599296.1	Code: S; COG: COG2353
YP_001599297.1	catalyzes the formation of fumarate from aspartate
YP_001599299.1	Code: S; COG: COG3671
YP_001599300.1	Code: S; COG: COG2606
YP_001599301.1	Code: J; COG: COG0251
YP_001599302.1	Code: R; COG: COG0354
YP_001599303.1	TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs
YP_001599305.1	Code: O; COG: COG0652
YP_001599306.1	Code: R; COG: COG0523
YP_001599307.1	Code: P; COG: COG0735
YP_001599308.1	Code: T; COG: COG0394
YP_001599309.1	Code: G; COG: COG1929
YP_001599312.1	Code: P; COG: COG2608
YP_001599314.1	Code: M; COG: COG1696
YP_001599315.1	Code: S; COG: COG2845
YP_001599316.1	Code: E; COG: COG2755
YP_001599318.1	activates fatty acids by binding to coenzyme A
YP_001599319.1	Code: M; COG: COG1292
YP_001599321.1	Code: L; COG: COG4389
YP_001599322.1	Code: M; COG: COG2951
YP_001599324.1	Code: I; COG: COG1960
YP_001599325.1	Code: LK; COG: COG1197
YP_001599326.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_001599327.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_001599329.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_001599330.1	Code: D; COG: COG2919
YP_001599331.1	Code: C; COG: COG0633
YP_001599332.1	B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA
YP_001599334.1	Code: L; COG: COG0270
YP_001599335.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_001599338.1	Code: I; COG: COG0204
YP_001599339.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_001599340.1	Code: QR; COG: COG0500
YP_001599341.1	Code: M; COG: COG0741
YP_001599342.1	Code: J; COG: COG1187
YP_001599343.1	Code: F; COG: COG0283
YP_001599344.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_001599345.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_001599346.1	Code: K; COG: COG0789
YP_001599347.1	Code: C; COG: COG1062
YP_001599348.1	Code: R; COG: COG0627
YP_001599349.1	Code: R; COG: COG1485
YP_001599350.1	Code: F; COG: COG0105
YP_001599351.1	Code: R; COG: COG0820
YP_001599352.1	Code: NU; COG: COG3063
YP_001599353.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_001599354.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_001599355.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_001599356.1	Code: D; COG: COG1674
YP_001599357.1	Code: F; COG: COG2233
YP_001599361.1	Code: I; COG: COG1183
YP_001599362.1	Code: R; COG: COG0730
YP_001599365.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_001599366.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_001599367.1	Code: L; COG: COG2965
YP_001599368.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_001599369.1	Code: O; COG: COG0492
YP_001599370.1	Code: P; COG: COG2217
YP_001599371.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_001599372.1	Code: R; COG: COG0790
YP_001599373.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_001599374.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_001599375.1	Code: M; COG: COG0793
YP_001599378.1	Code: S; COG: COG3045
YP_001599379.1	Code: K; COG: COG1678
YP_001599380.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_001599381.1	Code: Q; COG: COG0179
YP_001599382.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_001599384.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_001599385.1	Code: C; COG: COG0508
YP_001599386.1	Code: C; COG: COG1249
YP_001599387.1	Code: S; COG: COG5339
YP_001599388.1	Code: G; COG: COG0483
YP_001599389.1	Code: J; COG: COG0565
YP_001599390.1	Code: S; COG: COG3782
YP_001599391.1	Code: J; COG: COG0144
YP_001599393.1	Code: C; COG: COG1012
YP_001599394.1	Code: U; COG: COG2095
YP_001599396.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_001599397.1	Code: S; COG: COG2990
YP_001599398.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_001599399.1	Code: HC; COG: COG0543
YP_001599400.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate
YP_001599401.1	Code: J; COG: COG1187
YP_001599402.1	Code: GEPR; COG: COG0477
YP_001599403.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_001599404.1	Code: H; COG: COG0171
YP_001599406.1	Code: OC; COG: COG0526
YP_001599407.1	Code: R; COG: COG1092
YP_001599408.1	Code: LKJ; COG: COG0513
YP_001599412.1	DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate
YP_001599413.1	binds and unfolds substrates as part of the ClpXP protease
YP_001599414.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_001599415.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_001599416.1	Code: L; COG: COG2189
YP_001599418.1	Code: S; COG: COG3421
YP_001599419.1	Code: C; COG: COG1304
YP_001599421.1	Code: K; COG: COG1959
YP_001599422.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_001599424.1	Code: C; COG: COG0822
YP_001599425.1	Code: S; COG: COG0316
YP_001599426.1	Code: O; COG: COG1076
YP_001599427.1	Code: L; COG: COG0188
YP_001599428.1	Code: L; COG: COG3676
YP_001599432.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_001599433.1	Code: K; COG: COG1737
YP_001599434.1	catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate
YP_001599435.1	Code: G; COG: COG0363
YP_001599436.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_001599437.1	catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate
YP_001599438.1	catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate
YP_001599439.1	Code: ER; COG: COG1063
YP_001599440.1	Code: L; COG: COG1194
YP_001599443.1	Code: P; COG: COG2032
YP_001599444.1	Code: L; COG: COG3039
YP_001599446.1	Code: V; COG: COG2274
YP_001599447.1	Code: L; COG: COG3676
YP_001599449.1	Code: Q; COG: COG2931
YP_001599450.2	Code: E; COG: COG0308
YP_001599451.1	Code: L; COG: COG3298
YP_001599453.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_001599454.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_001599455.1	Code: KL; COG: COG2901
YP_001599456.1	Code: J; COG: COG0042
YP_001599457.1	Code: LKJ; COG: COG0513
YP_001599459.1	Code: L; COG: COG3039
YP_001599460.1	Code: S; COG: COG3792
YP_001599462.1	Code: L; COG: COG3039
YP_001599463.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_001599464.1	Code: P; COG: COG1914
YP_001599465.1	Code: E; COG: COG0006
YP_001599466.1	Code: M; COG: COG3203
YP_001599469.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_001599470.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_001599471.1	Code: M; COG: COG0791
YP_001599472.1	Code: I; COG: COG1502
YP_001599473.1	Code: GEPR; COG: COG0477
YP_001599474.1	Code: C; COG: COG0247
YP_001599475.1	Code: S; COG: COG1556
YP_001599476.1	Code: C; COG: COG1139
YP_001599477.1	Code: F; COG: COG0041
YP_001599478.1	Code: S; COG: COG1729
YP_001599479.1	Code: R; COG: COG4122
YP_001599481.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_001599482.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_001599483.1	Code: S; COG: COG0718
YP_001599484.2	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_001599485.1	catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis
YP_001599486.1	Code: L; COG: COG0210
YP_001599487.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_001599488.1	Code: P; COG: COG4773
YP_001599489.1	Code: P; COG: COG4773
YP_001599490.1	Code: C; COG: COG1018
YP_001599492.1	Code: R; COG: COG2070
YP_001599493.1	Code: S; COG: COG3198
YP_001599494.1	Code: C; COG: COG0348
YP_001599496.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_001599497.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_001599498.1	Code: GER; COG: COG0697
YP_001599499.1	Code: L; COG: COG0629
YP_001599500.1	Code: GEPR; COG: COG0477
YP_001599501.1	Code: M; COG: COG0741
YP_001599503.1	Code: L; COG: COG1943
YP_001599506.1	Code: FP; COG: COG0248
YP_001599509.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001599510.1	Code: O; COG: COG0542
YP_001599511.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_001599513.1	Code: P; COG: COG5266
YP_001599514.1	Code: E; COG: COG0334
YP_001599516.1	catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate
YP_001599517.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_001599519.1	Code: I; COG: COG1607
YP_001599520.1	Code: M; COG: COG0739
YP_001599521.1	Nucleoside 5'-monophosphate phosphohydrolase; catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_001599525.1	Code: C; COG: COG1012
YP_001599527.1	Code: T; COG: COG1966
YP_001599528.1	Code: S; COG: COG2879
YP_001599529.1	Code: P; COG: COG1629
YP_001599531.1	Code: E; COG: COG0527
YP_001599532.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_001599533.1	Code: T; COG: COG0589
YP_001599534.1	Code: H; COG: COG1179
YP_001599535.1	Code: S; COG: COG1354
YP_001599536.1	catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate
YP_001599537.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_001599539.1	Code: M; COG: COG1368
YP_001599540.1	Code: E; COG: COG0765
YP_001599541.1	Code: L; COG: COG1525
YP_001599542.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_001599543.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_001599544.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_001599545.1	Code: L; COG: COG0847
YP_001599547.1	Code: P; COG: COG3197
YP_001599549.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_001599551.1	two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm
YP_001599553.1	Code: I; COG: COG1562
YP_001599554.1	Code: O; COG: COG1047
YP_001599557.1	Code: C; COG: COG0277
YP_001599558.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_001599559.1	Code: M; COG: COG0859
YP_001599561.1	Code: L; COG: COG0350
YP_001599563.1	dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.
YP_001599566.1	Code: C; COG: COG3241
YP_001599569.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_001599570.1	synthesizes RNA primers at the replication forks
YP_001599571.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_001599577.1	Code: P; COG: COG1629
YP_001599580.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_001599581.1	Code: IQ; COG: COG0318
YP_001599582.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_001599583.1	Code: S; COG: COG2847
YP_001599584.1	Code: M; COG: COG0818
YP_001599585.1	catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
YP_001599586.1	catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001599587.1	Code: KG; COG: COG1349
YP_001599588.1	Code: S; COG: COG2431
YP_001599589.1	Code: K; COG: COG1802
YP_001599591.1	Code: O; COG: COG1765
YP_001599593.1	Code: F; COG: COG0299
YP_001599594.1	Code: O; COG: COG0545
YP_001599595.1	Code: L; COG: COG2927
YP_001599596.1	Code: E; COG: COG0260
YP_001599597.1	Code: R; COG: COG0795
YP_001599598.1	Code: R; COG: COG0795
YP_001599599.1	catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate
YP_001599600.1	catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway
YP_001599601.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_001599602.1	Code: S; COG: COG1359
YP_001599603.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_001599604.1	Code: EH; COG: COG0028
YP_001599605.1	Code: R; COG: COG1999
YP_001599606.1	short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ
YP_001599607.1	Code: S; COG: COG3680
YP_001599608.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_001599609.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_001599610.2	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis
YP_001599611.1	Code: I; COG: COG2084
YP_001599612.1	Code: K; COG: COG1846
YP_001599614.1	SohB; periplasmic protein; member of the peptidase S49 family
YP_001599615.1	Code: I; COG: COG0558
YP_001599617.1	Code: S; COG: COG0599
YP_001599618.1	Code: K; COG: COG2207
YP_001599620.1	Code: GER; COG: COG0697
YP_001599621.1	Code: E; COG: COG0687
YP_001599622.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001599624.1	Code: V; COG: COG1002
YP_001599626.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_001599627.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_001599628.1	Code: T; COG: COG0642
YP_001599629.1	Code: T; COG: COG2204
YP_001599630.1	Code: QR; COG: COG0500
YP_001599632.1	Code: E; COG: COG0626
YP_001599635.1	Code: ET; COG: COG0834
YP_001599636.1	Code: C; COG: COG1951
YP_001599637.1	involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain
YP_001599638.1	Code: L; COG: COG2826
YP_001599639.1	Code: L; COG: COG3039
YP_001599641.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_001599642.1	with TehA confers resistance to tellurite
YP_001599643.1	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_001599644.1	Code: FGR; COG: COG0537
YP_001599645.1	Code: V; COG: COG1619
YP_001599646.1	Code: O; COG: COG0386
YP_001599647.1	Code: P; COG: COG3256
YP_001599648.1	Code: L; COG: COG2826
YP_001599649.1	Code: NU; COG: COG4969
YP_001599650.1	Code: NU; COG: COG4969
YP_001599651.1	Code: NU; COG: COG4969
YP_001599653.1	Code: C; COG: COG0778
YP_001599654.1	Code: R; COG: COG2194
YP_001599656.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_001599657.1	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_001599658.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_001599659.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_001599662.1	Code: R; COG: COG1272
YP_001599663.1	Code: E; COG: COG1115
YP_001599664.1	Code: S; COG: COG0217
YP_001599665.1	Code: O; COG: COG1495
YP_001599667.1	Code: M; COG: COG0787
YP_001599668.1	Code: L; COG: COG3676
YP_001599669.1	Code: S; COG: COG2848
YP_001599670.1	ACT domain-containing protein
YP_001599671.1	Code: S; COG: COG2849
YP_001599673.1	involved in methylation of ribosomal protein L3
YP_001599677.1	Code: H; COG: COG0452
YP_001599678.1	Code: TK; COG: COG0317
YP_001599679.1	Code: K; COG: COG1758
YP_001599680.1	Essential for recycling GMP and indirectly, cGMP
YP_001599681.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_001599682.1	Code: R; COG: COG0561
YP_001599684.1	Code: O; COG: COG0826
YP_001599686.1	Code: S; COG: COG3744
YP_001599687.1	Code: D; COG: COG4118
YP_001599688.1	Code: P; COG: COG3230
YP_001599689.1	Code: S; COG: COG2995
YP_001599690.1	Code: R; COG: COG3008
YP_001599691.1	Code: S; COG: COG3009
YP_001599692.1	Code: L; COG: COG2818
YP_001599693.1	Code: E; COG: COG2755
YP_001599695.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_001599697.1	Code: C; COG: COG3245
YP_001599698.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_001599699.1	catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs
YP_001599700.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_001599702.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_001599703.1	hydrolyzes diadenosine polyphosphate
YP_001599704.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001599705.1	Code: CHR; COG: COG1052
YP_001599706.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_001599707.1	Code: L; COG: COG0084
YP_001599708.1	Code: EJ; COG: COG0252
YP_001599709.1	Code: S; COG: COG0586
YP_001599710.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_001599711.1	Code: H; COG: COG0294
YP_001599712.1	Code: E; COG: COG2876
YP_001599713.1	Code: M; COG: COG2982
YP_001599714.1	Code: H; COG: COG0043
YP_001599715.1	Code: S; COG: COG4899
YP_001599716.1	Code: S; COG: COG4648
YP_001599719.1	Code: L; COG: COG3676
YP_001599720.1	FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_001599721.1	Code: M; COG: COG0463
YP_001599722.1	Code: M; COG: COG0438
YP_001599723.1	Code: R; COG: COG0733
YP_001599724.1	Code: H; COG: COG1477
YP_001599726.1	Code: F; COG: COG0207
YP_001599727.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_001599728.1	similar to related acetyltransferases
YP_001599729.1	Code: K; COG: COG2186
YP_001599730.1	Code: C; COG: COG1620
YP_001599732.1	Code: MU; COG: COG1538
YP_001599733.1	Code: V; COG: COG0841
YP_001599734.1	Code: M; COG: COG0845
YP_001599735.1	Code: K; COG: COG1309
YP_001599737.1	Code: H; COG: COG2978
YP_001599738.1	Code: L; COG: COG1330
YP_001599739.1	Code: S; COG: COG3182
YP_001599740.1	Code: C; COG: COG3245
YP_001599741.1	Code: C; COG: COG2010
YP_001599742.1	Code: O; COG: COG4736
YP_001599743.1	CcoO; FixO
YP_001599744.1	CcoN; FixN
YP_001599745.1	Code: R; COG: COG3975
YP_001599746.1	Code: S; COG: COG3453
YP_001599747.1	Code: U; COG: COG0848
YP_001599748.1	Code: U; COG: COG0811
YP_001599749.1	Code: M; COG: COG0810
YP_001599750.1	Code: R; COG: COG1994
YP_001599751.1	Code: P; COG: COG1230
YP_001599753.1	cofactor involved in the reduction of disulfides
YP_001599754.1	Code: TK; COG: COG0317
YP_001599756.1	Code: MU; COG: COG1538
YP_001599757.1	Code: M; COG: COG0845
YP_001599760.1	Code: L; COG: COG2946
YP_001599769.1	Code: R; COG: COG2229
YP_001599772.1	Code: QR; COG: COG0500
YP_001599773.1	Code: S; COG: COG2830
YP_001599774.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_001599775.1	Code: S; COG: COG1376
YP_001599776.1	Code: P; COG: COG0471
YP_001599777.1	catalyzes the formation of putrescine from agmatine
YP_001599778.1	catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis
YP_001599780.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_001599781.1	Code: S; COG: COG2928
YP_001599782.1	Code: M; COG: COG2829
YP_001599783.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_001599784.1	Code: E; COG: COG0687
YP_001599785.1	Code: P; COG: COG1629
YP_001599787.1	Code: S; COG: COG3177
YP_001599788.1	Code: L; COG: COG3039
YP_001599789.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_001599790.1	Code: R; COG: COG0802
YP_001599791.1	Code: M; COG: COG0860
YP_001599792.1	Code: S; COG: COG3177
YP_001599793.1	Code: L; COG: COG0116
YP_001599795.1	Code: LR; COG: COG0494
YP_001599796.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_001599797.1	Code: R; COG: COG0730
YP_001599799.1	involved in the de novo synthesis of pyridoxine (Vitamin B6)
YP_001599800.1	Code: L; COG: COG1381
YP_001599801.1	Code: E; COG: COG0077
YP_001599802.1	Code: GEPR; COG: COG0477
YP_001599804.1	Code: GER; COG: COG0697
YP_001599805.1	Code: L; COG: COG3039
YP_001599808.1	Code: R; COG: COG0388
YP_001599809.1	Code: E; COG: COG0287
YP_001599810.1	Code: P; COG: COG3213
YP_001599812.1	Code: K; COG: COG1959
YP_001599813.1	Code: J; COG: COG0009
YP_001599814.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_001599815.1	Code: S; COG: COG2828
YP_001599816.1	Catalyzes the conversion of citrate to isocitrate
YP_001599817.1	catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity
YP_001599818.1	catalyzes the formation of pyruvate and succinate from 2-methylisocitrate
YP_001599819.1	Code: R; COG: COG2252
YP_001599820.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_001599821.1	Code: D; COG: COG0849
YP_001599822.1	Code: M; COG: COG1589
YP_001599823.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_001599824.2	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_001599825.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_001599826.1	Code: D; COG: COG0772
YP_001599827.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_001599828.1	Code: R; COG: COG0790
YP_001599829.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_001599831.1	Code: M; COG: COG0770
YP_001599832.1	Code: R; COG: COG2194
YP_001599833.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_001599834.1	Code: M; COG: COG0768
YP_001599835.1	Code: S; COG: COG3117
YP_001599836.1	Code: M; COG: COG0275
YP_001599837.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_001599838.1	Code: S; COG: COG1565
YP_001599839.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_001599840.1	Code: OC; COG: COG0526
YP_001599841.1	Code: D; COG: COG3087
YP_001599842.1	Code: O; COG: COG0606
YP_001599843.1	Code: S; COG: COG2960
YP_001599844.1	Code: ER; COG: COG0591
YP_001599845.2	proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain
YP_001599846.1	Code: L; COG: COG3547
YP_001599847.1	Code: L; COG: COG0708
YP_001599848.1	Code: K; COG: COG0640
YP_001599849.1	Code: H; COG: COG0157
YP_001599850.1	Code: R; COG: COG4111
YP_001599851.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_001599852.1	Code: H; COG: COG0029
YP_001599853.1	Code: R; COG: COG0637
YP_001599854.1	Code: G; COG: COG1554
YP_001599855.1	Code: G; COG: COG2017
YP_001599856.1	Code: GEPR; COG: COG0477
YP_001599857.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_001599858.1	Code: I; COG: COG1267
YP_001599859.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_001599860.1	Code: M; COG: COG2885
YP_001599861.1	Code: K; COG: COG0583
YP_001599862.1	Code: T; COG: COG0664
YP_001599863.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_001599864.1	Code: P; COG: COG0306
YP_001599866.1	catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling
YP_001599879.1	Code: Q; COG: COG2931
YP_001599881.1	Code: L; COG: COG2827
YP_001599882.1	Code: GEPR; COG: COG0477
YP_001599883.1	Code: E; COG: COG0174
YP_001599884.1	Code: E; COG: COG0169
YP_001599885.1	glycosyltransferase; polymerizes glycan strands in the peptidoglycan
YP_001599886.1	Code: R; COG: COG1137
YP_001599887.1	Code: S; COG: COG1934
YP_001599888.1	Code: S; COG: COG3117
YP_001599889.1	Code: R; COG: COG1778
YP_001599890.1	Code: M; COG: COG0794
YP_001599891.1	catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate
YP_001599893.1	this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu
YP_001599894.1	Code: J; COG: COG0042
YP_001599895.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_001599896.1	Code: O; COG: COG0760
YP_001599897.1	Code: O; COG: COG0760
YP_001599898.1	Code: T; COG: COG0271
YP_001599899.1	unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity
YP_001599900.1	Involved in cell division; probably involved in intracellular septation
YP_001599901.1	Code: NU; COG: COG3170
YP_001599902.1	Code: E; COG: COG0346
YP_001599903.1	Code: G; COG: COG2956
YP_001599904.1	Code: S; COG: COG5416
YP_001599906.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_001599907.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_001599908.1	catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway
YP_001599909.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_001599910.1	Code: NU; COG: COG1459
YP_001599911.1	Code: NOU; COG: COG1989
YP_001599912.1	Code: H; COG: COG0237
YP_001599913.1	Code: S; COG: COG3024
YP_001599914.1	Code: NU; COG: COG2804
YP_001599915.1	Code: S; COG: COG2707
YP_001599916.1	Code: H; COG: COG0142
YP_001599917.1	Code: J; COG: COG0261
YP_001599918.1	involved in the peptidyltransferase reaction during translation
YP_001599919.1	Code: HC; COG: COG0654
YP_001599921.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_001599922.1	required for 70S ribosome assembly
YP_001599924.1	Code: GEPR; COG: COG0477
YP_001599925.1	Code: V; COG: COG1566
YP_001599926.1	NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis
YP_001599927.1	Code: S; COG: COG1738
YP_001599928.1	Code: M; COG: COG0739
YP_001599929.1	Code: S; COG: COG4255
YP_001599931.1	Code: MU; COG: COG3468
YP_001599933.1	Code: S; COG: COG1981
YP_001599934.1	Code: S; COG: COG2954
YP_001599935.1	Code: H; COG: COG0262
YP_001599936.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_001599939.1	Code: L; COG: COG3676
YP_001599941.1	Code: R; COG: COG4137
YP_001599942.1	Code: U; COG: COG0541
YP_001599943.1	Code: OC; COG: COG0526
YP_001599944.1	Code: S; COG: COG1432
YP_001599945.1	Code: R; COG: COG3560
YP_001599946.1	Code: S; COG: COG2259
YP_001599947.1	Code: K; COG: COG0583
YP_001599948.1	Code: L; COG: COG0415
YP_001599949.1	helicase involved in DNA repair and perhaps also replication
YP_001599950.1	Code: S; COG: COG2979
YP_001599951.1	Code: I; COG: COG1835
YP_001599952.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_001599953.1	Code: R; COG: COG1611
YP_001599954.1	Code: K; COG: COG0557
YP_001599955.1	Code: O; COG: COG0760
YP_001599956.1	Code: M; COG: COG1452
YP_001599957.1	Code: R; COG: COG3178
YP_001599958.1	Code: OC; COG: COG0526
YP_001599959.1	Code: R; COG: COG0728
YP_001599960.1	Code: R; COG: COG0429
YP_001599961.1	involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water
YP_001599962.1	Code: L; COG: COG0514
YP_001599965.1	Code: QR; COG: COG0500
YP_001599966.1	Code: R; COG: COG0596
YP_001599967.1	Code: R; COG: COG1040
YP_001599968.1	Code: J; COG: COG0219
YP_001599969.1	Code: M; COG: COG0797
YP_001599970.1	Code: S; COG: COG3212
YP_001599971.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_001599973.1	Code: V; COG: COG1132
YP_001599974.1	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_001599975.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_001599976.1	Code: H; COG: COG0142
YP_001599978.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001599979.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001599980.1	Code: S; COG: COG1479
YP_001599981.1	Code: G; COG: COG0662
YP_001599982.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_001599984.1	Code: D; COG: COG2184
YP_001599985.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001599986.1	Code: C; COG: COG0839
YP_001599987.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001599988.1	Code: C; COG: COG1005
YP_001599989.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_001599990.1	Code: L; COG: COG2827
YP_001599991.1	Code: C; COG: COG1894
YP_001599992.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001599993.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001599994.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001599995.1	Code: C; COG: COG0377
YP_001599996.1	Code: C; COG: COG0838
YP_001599999.1	Code: L; COG: COG3676
YP_001600003.1	Code: L; COG: COG0210
YP_001600005.1	Code: E; COG: COG2049
YP_001600006.1	Code: E; COG: COG1984
YP_001600007.1	Code: R; COG: COG1540
YP_001600008.1	Code: P; COG: COG1914
YP_001600009.1	Code: R; COG: COG1451
YP_001600010.1	Code: L; COG: COG2826
YP_001600011.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_001600013.1	Code: S; COG: COG4304
YP_001600015.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_001600016.1	carries the fatty acid chain in fatty acid biosynthesis
YP_001600017.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_001600018.1	Code: M; COG: COG0438
YP_001600019.1	Code: P; COG: COG0753
YP_001600020.1	Code: S; COG: COG1971
YP_001600021.1	Code: E; COG: COG0339
YP_001600022.1	Code: M; COG: COG0668
YP_001600023.1	negatively supercoils closed circular double-stranded DNA
YP_001600024.1	Code: E; COG: COG1760
YP_001600026.1	Code: C; COG: COG2878
YP_001600027.1	Code: G; COG: COG0057
YP_001600028.1	leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys
YP_001600029.1	Code: P; COG: COG0735
YP_001600030.1	Code: J; COG: COG2913
YP_001600031.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_001600035.1	catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_001600036.1	Code: J; COG: COG0564
YP_001600038.1	Code: J; COG: COG1530
YP_001600041.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_001600042.1	Code: E; COG: COG1115
YP_001600043.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_001600044.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_001600046.1	Code: D; COG: COG1192
YP_001600047.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_001600049.1	Code: S; COG: COG1289
YP_001600050.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_001600051.1	Code: I; COG: COG0020
YP_001600052.1	Code: I; COG: COG0575
YP_001600053.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_001600054.1	Code: M; COG: COG0750
YP_001600055.1	Code: M; COG: COG4775
YP_001600056.1	Code: M; COG: COG2825
YP_001600057.1	adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_001600058.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_001600059.1	catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_001600060.1	Code: E; COG: COG1115
YP_001600061.1	catalyzes the oxidative deamination of D-amino acids
YP_001600062.1	Code: P; COG: COG0428
YP_001600063.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_001600064.1	Code: K; COG: COG0583
YP_001600065.1	works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell
YP_001600066.1	Code: D; COG: COG2894
YP_001600067.1	blocks the formation of polar Z-ring septums
YP_001600068.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_001600069.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_001600070.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_001600071.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_001600072.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_001600073.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_001600074.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_001600075.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_001600076.1	late assembly protein
YP_001600077.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_001600078.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_001600079.1	binds 5S rRNA along with protein L5 and L25
YP_001600080.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_001600081.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_001600082.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_001600083.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_001600084.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_001600085.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_001600086.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_001600087.1	one of the stabilizing components for the large ribosomal subunit
YP_001600088.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_001600089.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_001600090.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_001600091.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_001600092.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_001600093.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_001600094.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_001600095.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_001600096.1	Code: L; COG: COG3039
YP_001600097.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_001600098.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_001600099.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_001600100.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_001600101.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_001600102.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_001600103.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_001600104.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_001600105.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_001600106.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_001600107.1	binds directly to 23S ribosomal RNA
YP_001600108.1	Code: K; COG: COG0250
YP_001600109.1	forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_001600110.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_001600111.1	Code: C; COG: COG1145
YP_001600112.1	Code: L; COG: COG0742
YP_001600113.1	Code: K; COG: COG1396
YP_001600116.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity
YP_001600117.1	Code: S; COG: COG2922
YP_001600118.1	Code: LU; COG: COG0758
YP_001600119.1	Code: T; COG: COG2204
YP_001600120.1	Code: T; COG: COG5000
YP_001600122.1	Code: J; COG: COG0144
YP_001600123.1	Code: R; COG: COG2110
YP_001600124.1	Code: J; COG: COG0223
YP_001600125.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_001600127.1	Code: S; COG: COG1652
YP_001600129.1	involved in the allosteric regulation of aspartate carbamoyltransferase
YP_001600130.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_001600131.1	Code: KR; COG: COG0454
YP_001600135.1	Code: R; COG: COG3271
YP_001600137.1	Code: L; COG: COG3676
YP_001600138.1	Code: R; COG: COG0313
YP_001600139.1	Code: L; COG: COG0792
YP_001600140.1	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_001600141.1	Code: R; COG: COG2823
YP_001600143.1	Code: J; COG: COG0024
YP_001600146.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_001600147.1	Code: J; COG: COG1670
YP_001600148.1	Code: H; COG: COG0212
YP_001600150.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_001600151.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_001600152.1	Catalyzes the phosphorylation of UMP to UDP
YP_001600170.1	Code: OU; COG: COG0616
YP_001600171.1	Code: R; COG: COG1058
YP_001600172.1	catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis
YP_001600175.1	involved in the import of serine and threonine coupled with the import of sodium
YP_001600176.1	Code: M; COG: COG0729
YP_001600177.1	Code: S; COG: COG2911
YP_001600178.1	Code: L; COG: COG3039
YP_001600179.1	Code: E; COG: COG3104
YP_001600181.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_001600182.1	Code: R; COG: COG1752
YP_001600183.1	Code: S; COG: COG2259
YP_001600184.1	Code: S; COG: COG3767
YP_001600185.1	Code: S; COG: COG3220
YP_001600186.1	Code: S; COG: COG3219
YP_001600187.1	Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
YP_001600191.1	Code: L; COG: COG3676
YP_001600192.1	Code: J; COG: COG0009
YP_001600193.1	Code: L; COG: COG3039
YP_001600194.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_001600196.1	Code: S; COG: COG1739
YP_001600197.1	Code: C; COG: COG2025
YP_001600198.1	Code: C; COG: COG2086
YP_001600199.1	Code: M; COG: COG0859
YP_001600200.1	Code: Q; COG: COG1335
YP_001600201.1	Code: S; COG: COG1720
YP_001600203.1	Code: G; COG: COG0057
YP_001600204.1	This protein performs the mismatch recognition step during the DNA repair process