-- dump date 20140619_163221 -- class Genbank::misc_feature -- table misc_feature_note -- id note 604162000001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 604162000002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 604162000003 Coenzyme A binding pocket [chemical binding]; other site 604162000004 Transposon insertion site of 62/12 mutant 604162000005 AAA domain; Region: AAA_13; pfam13166 604162000006 Transposon insertion site of 70/37 mutant 604162000007 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 604162000008 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 604162000009 active site 604162000010 HIGH motif; other site 604162000011 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 604162000012 active site 604162000013 KMSKS motif; other site 604162000014 Uncharacterized conserved protein [Function unknown]; Region: COG1434 604162000015 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 604162000016 putative active site [active] 604162000017 Transposon insertion site of 12/17 mutant 604162000018 Transposon insertion site of 12/19 mutant 604162000019 Transposon insertion site of 1/21 mutant 604162000020 Transposon insertion site of 94/38 mutant 604162000021 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 604162000022 ArsC family; Region: ArsC; pfam03960 604162000023 catalytic residues [active] 604162000024 Transposon insertion site of 35/28 mutant 604162000025 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 604162000026 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 604162000027 catalytic residues [active] 604162000028 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 604162000029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 604162000030 Walker A/P-loop; other site 604162000031 ATP binding site [chemical binding]; other site 604162000032 Q-loop/lid; other site 604162000033 ABC transporter signature motif; other site 604162000034 Walker B; other site 604162000035 D-loop; other site 604162000036 H-loop/switch region; other site 604162000037 Transposon insertion site of 78/45 mutant 604162000038 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 604162000039 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 604162000040 Transposon insertion site of 93/43 mutant 604162000041 Transposon insertion site of 16/5 mutant 604162000042 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 604162000043 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 604162000044 Phosphoglycerate kinase; Region: PGK; pfam00162 604162000045 substrate binding site [chemical binding]; other site 604162000046 hinge regions; other site 604162000047 ADP binding site [chemical binding]; other site 604162000048 catalytic site [active] 604162000049 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 604162000050 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 604162000051 hinge; other site 604162000052 active site 604162000053 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 604162000054 Transposon insertion site of 40/40 mutant 604162000055 Transposon insertion site of 92/11 mutant 604162000056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 604162000057 Transposon insertion site of 46/9 mutant 604162000058 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 604162000059 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 604162000060 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 604162000061 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 604162000062 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 604162000063 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 604162000064 Transposon insertion site of 89/26 mutant 604162000065 Transposon insertion site of 56/36 mutant 604162000066 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 604162000067 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 604162000068 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 604162000069 Pilin (bacterial filament); Region: Pilin; pfam00114 604162000070 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 604162000071 Transposon insertion site of 23/12 mutant 604162000072 Transposon insertion site of 7/28 mutant 604162000073 'Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 2866848, 2897186; Product type s : structure' 604162000074 'Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 2866848, 2897186; Product type s : structure' 604162000075 'Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 2866848, 2897186; Product type s : structure' 604162000076 Transposon insertion site of 91/7 mutant 604162000077 'Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 2866848, 2897186; Product type s : structure' 604162000078 Transposon insertion site of 70/27 mutant 604162000079 Transposon insertion site of 57/8 mutant 604162000080 'Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 2866848, 2897186; Product type s : structure' 604162000081 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 604162000082 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 604162000083 Transposon insertion site of 88/16 mutant 604162000084 Predicted membrane protein [Function unknown]; Region: COG3205 604162000085 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 604162000086 glycerate dehydrogenase; Provisional; Region: PRK06487 604162000087 putative ligand binding site [chemical binding]; other site 604162000088 putative NAD binding site [chemical binding]; other site 604162000089 catalytic site [active] 604162000090 Transposon insertion site of 61/7 mutant 604162000091 Transposon insertion site of 39/20 mutant 604162000092 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 604162000093 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 604162000094 active site 604162000095 HIGH motif; other site 604162000096 KMSKS motif; other site 604162000097 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 604162000098 tRNA binding surface [nucleotide binding]; other site 604162000099 anticodon binding site; other site 604162000100 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 604162000101 dimer interface [polypeptide binding]; other site 604162000102 putative tRNA-binding site [nucleotide binding]; other site 604162000103 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 604162000104 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 604162000105 glutaminase active site [active] 604162000106 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 604162000107 dimer interface [polypeptide binding]; other site 604162000108 active site 604162000109 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 604162000110 dimer interface [polypeptide binding]; other site 604162000111 active site 604162000112 Transposon insertion site of 28/42 mutant 604162000113 Transposon insertion site of 76/44 mutant 604162000114 Transposon insertion site of 26/48 mutant 604162000115 Transposon insertion site of 52/48 mutant 604162000116 Transposon insertion site of 9/21 mutant 604162000117 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 604162000118 MltA specific insert domain; Region: MltA; pfam03562 604162000119 3D domain; Region: 3D; pfam06725 604162000120 Transposon insertion site of 70/13 mutant 604162000121 Transposon insertion site of 73/24 mutant 604162000122 Transposon insertion site of 76/7 mutant 604162000123 Transposon insertion site of 87/29 mutant 604162000124 Transposon insertion site of 6/29 mutant 604162000125 Transposon insertion site of 94/23 mutant 604162000126 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 604162000127 Transposon insertion site of 49/41 mutant 604162000128 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 604162000129 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 604162000130 Imelysin; Region: Peptidase_M75; pfam09375 604162000131 Transposon insertion site of 28/48 mutant 604162000132 Transposon insertion site of 31/16 mutant 604162000133 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 604162000134 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 604162000135 Transposon insertion site of 49/22 mutant 604162000136 Transposon insertion site of 33/35 mutant 604162000137 Transposon insertion site of 72/35 mutant 604162000138 Transposon insertion site of 57/45 mutant 604162000139 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 604162000140 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 604162000141 PhnA protein; Region: PhnA; pfam03831 604162000142 Transposon insertion site of 43/25 mutant 604162000143 Transposon insertion site of 59/43 mutant 604162000144 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 604162000145 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 604162000146 Substrate binding site; other site 604162000147 Mg++ binding site; other site 604162000148 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 604162000149 active site 604162000150 substrate binding site [chemical binding]; other site 604162000151 CoA binding site [chemical binding]; other site 604162000152 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 604162000153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 604162000154 motif II; other site 604162000155 Transposon insertion site of 66/12 mutant 604162000156 Transposon insertion site of 38/2 mutant 604162000157 Transposon insertion site of 58/6 mutant 604162000158 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 604162000159 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 604162000160 Transposon insertion site of 1/38 mutant 604162000161 Transposon insertion site of 75/46 mutant 604162000162 Transposon insertion site of 74/9 mutant 604162000163 Transposon insertion site of 83/6 mutant 604162000164 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 604162000165 Conserved TM helix; Region: TM_helix; pfam05552 604162000166 Mechanosensitive ion channel; Region: MS_channel; pfam00924 604162000167 Competence-damaged protein; Region: CinA; pfam02464 604162000168 Transposon insertion site of 16/1 mutant 604162000169 trifunctional thioredoxin/methionine sulfoxide reductase A/B protein; Provisional; Region: PRK14018 604162000170 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 604162000171 catalytic residues [active] 604162000172 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 604162000173 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 604162000174 Transposon insertion site of 84/26 mutant 604162000175 Transposon insertion site of 41/14 mutant 604162000176 Transposon insertion site of 65/1 mutant 604162000177 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 604162000178 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 604162000179 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 604162000180 P loop; other site 604162000181 GTP binding site [chemical binding]; other site 604162000182 Transposon insertion site of 45/23 mutant 604162000183 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 604162000184 GIY-YIG motif/motif A; other site 604162000185 putative active site [active] 604162000186 putative metal binding site [ion binding]; other site 604162000187 Transposon insertion site of 10/43 mutant 604162000188 Transposon insertion site of 25/41 mutant 604162000189 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 604162000190 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 604162000191 Transposon insertion site of 94/28 mutant 604162000192 Transposon insertion site of 2/26 mutant 604162000193 Transposon insertion site of 21/4 mutant 604162000194 TIGR01666 family membrane protein; Region: YCCS 604162000195 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 604162000196 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 604162000197 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 604162000198 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 604162000199 Walker A motif; other site 604162000200 ATP binding site [chemical binding]; other site 604162000201 Walker B motif; other site 604162000202 Transposon insertion site of TU3 mutant 604162000203 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 604162000204 SPOC domain; Region: SPOC; pfam07744 604162000205 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 604162000206 Walker A motif; other site 604162000207 ATP binding site [chemical binding]; other site 604162000208 Walker B motif; other site 604162000209 Transposon insertion site of TU2 mutant 604162000210 Transposon insertion site of TU5 mutant 604162000211 Transposon insertion site of 65/30 mutant 604162000212 Transposon insertion site of TU6 mutant 604162000213 Transposon insertion site of TU1 mutant 604162000214 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 604162000215 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 604162000216 catalytic residue [active] 604162000217 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 604162000218 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 604162000219 Transposon insertion site of 88/6 mutant 604162000220 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 604162000221 Transposon insertion site of 68/30 mutant 604162000222 Transposon insertion site of 22/22 mutant 604162000223 comEA protein; Region: comE; TIGR01259 604162000224 Helix-hairpin-helix motif; Region: HHH; pfam00633 604162000225 chaperone protein DnaJ; Provisional; Region: PRK10767 604162000226 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 604162000227 HSP70 interaction site [polypeptide binding]; other site 604162000228 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 604162000229 substrate binding site [polypeptide binding]; other site 604162000230 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 604162000231 Zn binding sites [ion binding]; other site 604162000232 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 604162000233 dimer interface [polypeptide binding]; other site 604162000234 Predicted membrane protein [Function unknown]; Region: COG1297 604162000235 putative oligopeptide transporter, OPT family; Region: TIGR00733 604162000236 Transposon insertion site of 55/35 mutant 604162000237 Transposon insertion site of 65/45 mutant 604162000238 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 604162000239 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 604162000240 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 604162000241 substrate binding site; other site 604162000242 tetramer interface; other site 604162000243 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 604162000244 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 604162000245 NAD binding site [chemical binding]; other site 604162000246 substrate binding site [chemical binding]; other site 604162000247 homodimer interface [polypeptide binding]; other site 604162000248 active site 604162000249 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 604162000250 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 604162000251 NAD binding site [chemical binding]; other site 604162000252 homodimer interface [polypeptide binding]; other site 604162000253 active site 604162000254 substrate binding site [chemical binding]; other site 604162000255 Transposon insertion site of 61/44 mutant 604162000256 Transposon insertion site of 77/4 mutant 604162000257 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 604162000258 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 604162000259 Transposon insertion site of 5/16 mutant 604162000260 Transposon insertion site of 50/10 mutant 604162000261 Transposon insertion site of 58/47 mutant 604162000262 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 604162000263 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 604162000264 NeuB family; Region: NeuB; pfam03102 604162000265 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 604162000266 NeuB binding interface [polypeptide binding]; other site 604162000267 putative substrate binding site [chemical binding]; other site 604162000268 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 604162000269 ligand binding site; other site 604162000270 tetramer interface; other site 604162000271 Transposon insertion site of 28/22 mutant 604162000272 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 604162000273 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 604162000274 active site 604162000275 homodimer interface [polypeptide binding]; other site 604162000276 Transposon insertion site of 74/2 mutant 604162000277 Transposon insertion site of 77/19 mutant 604162000278 Transposon insertion site of 76/14 mutant 604162000279 Transposon insertion site of 63/19 mutant 604162000280 Transposon insertion site of 3/16 mutant 604162000281 Transposon insertion site of 54/26 mutant 604162000282 Transposon insertion site of 17/10 mutant 604162000283 Transposon insertion site of 73/40 mutant 604162000284 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 604162000285 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 604162000286 Transposon insertion site of 43/8 mutant 604162000287 Transposon insertion site of 13/16 mutant 604162000288 Transposon insertion site of 40/45 mutant 604162000289 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 604162000290 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 604162000291 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 604162000292 Transposon insertion site of 85/40 mutant 604162000293 Transposon insertion site of 59/42 mutant 604162000294 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 604162000295 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 604162000296 Walker A/P-loop; other site 604162000297 ATP binding site [chemical binding]; other site 604162000298 Q-loop/lid; other site 604162000299 ABC transporter signature motif; other site 604162000300 Walker B; other site 604162000301 D-loop; other site 604162000302 H-loop/switch region; other site 604162000303 Transposon insertion site of 18/15 mutant 604162000304 Transposon insertion site of 93/47 mutant 604162000305 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 604162000306 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 604162000307 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 604162000308 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 604162000309 RNA binding site [nucleotide binding]; other site 604162000310 Transposon insertion site of 89/25 mutant 604162000311 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 9321671; Product type e : enzyme 604162000312 Transposon insertion site of 56/14 mutant 604162000313 Transposon insertion site of 15/20 mutant 604162000314 Transposon insertion site of 13/21 mutant 604162000315 Transposon insertion site of 52/8 mutant 604162000316 Transposon insertion site of 25/6 mutant 604162000317 Transposon insertion site of 13/3 mutant 604162000318 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 9321671; Product type e : enzyme 604162000319 Evidence 7 : Gene remnant; PubMedId : 9321671; Product type e : enzyme 604162000320 Transposon insertion site of 86/36 mutant 604162000321 Transposon insertion site of 68/9 mutant 604162000322 Evidence 7 : Gene remnant 604162000323 Transposon insertion site of 55/31 mutant 604162000324 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 604162000325 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 604162000326 NAD binding site [chemical binding]; other site 604162000327 substrate binding site [chemical binding]; other site 604162000328 homodimer interface [polypeptide binding]; other site 604162000329 active site 604162000330 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 604162000331 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 604162000332 substrate binding site; other site 604162000333 tetramer interface; other site 604162000334 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 604162000335 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 604162000336 Transposon insertion site of 35/29 mutant 604162000337 Transposon insertion site of 41/29 mutant 604162000338 Transposon insertion site of 93/19 mutant 604162000339 Transposon insertion site of 34/3 mutant 604162000340 Transposon insertion site of 80/4 mutant 604162000341 Transposon insertion site of 58/48 mutant 604162000342 Transposon insertion site of 44/41 mutant 604162000343 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 604162000344 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 604162000345 Transposon insertion site of 29/41 mutant 604162000346 Transposon insertion site of 86/2 mutant 604162000347 Transposon insertion site of 19/14 mutant 604162000348 Transposon insertion site of 80/24 mutant 604162000349 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 604162000350 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 604162000351 Sel1-like repeats; Region: SEL1; smart00671 604162000352 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 604162000353 Sel1-like repeats; Region: SEL1; smart00671 604162000354 Sel1-like repeats; Region: SEL1; smart00671 604162000355 Transposon insertion site of 69/33 mutant 604162000356 Transposon insertion site of 19/1 mutant 604162000357 Transposon insertion site of 57/10 mutant 604162000358 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 604162000359 Transposon insertion site of 33/29 mutant 604162000360 Transposon insertion site of 30/13 mutant 604162000361 Transposon insertion site of 62/46 mutant 604162000362 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 604162000363 Transposon insertion site of 9/42 mutant 604162000364 Transposon insertion site of 24/28 mutant 604162000365 Transposon insertion site of 86/17 mutant 604162000366 cyanate hydratase; Validated; Region: PRK02866 604162000367 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 604162000368 Transposon insertion site of 77/3 mutant 604162000369 Transposon insertion site of 40/9 mutant 604162000370 Transposon insertion site of 65/5 mutant 604162000371 Transposon insertion site of 60/40 mutant 604162000372 Transposon insertion site of 53/40 mutant 604162000373 pyruvate kinase; Provisional; Region: PRK05826 604162000374 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 604162000375 domain interfaces; other site 604162000376 active site 604162000377 Transposon insertion site of 26/24 mutant 604162000378 Transposon insertion site of 38/26 mutant 604162000379 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162000380 Transposon insertion site of 81/47 mutant 604162000381 Transposon insertion site of 26/2 mutant 604162000382 Transposon insertion site of 26/9 mutant 604162000383 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162000384 Transposon insertion site of 17/24 mutant 604162000385 Transposon insertion site of 4/18 mutant 604162000386 Transposon insertion site of 1/4 mutant 604162000387 Transposon insertion site of 51/40 mutant 604162000388 Transposon insertion site of 76/25 mutant 604162000389 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 604162000390 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 604162000391 HlyD family secretion protein; Region: HlyD_3; pfam13437 604162000392 Transposon insertion site of 57/40 mutant 604162000393 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162000394 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162000395 Transposon insertion site of 32/20 mutant 604162000396 Transposon insertion site of 90/28 mutant 604162000397 Transposon insertion site of 16/42 mutant 604162000398 Transposon insertion site of 52/33 mutant 604162000399 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162000400 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162000401 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 604162000402 putative active site [active] 604162000403 Transposon insertion site of 51/35 mutant 604162000404 Transposon insertion site of 79/24 mutant 604162000405 Transposon insertion site of 10/1 mutant 604162000406 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 604162000407 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 604162000408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 604162000409 Coenzyme A binding pocket [chemical binding]; other site 604162000410 Transposon insertion site of 38/8 mutant 604162000411 Transposon insertion site of 21/9 mutant 604162000412 Transposon insertion site of 84/31 mutant 604162000413 Transposon insertion site of 18/46 mutant 604162000414 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 604162000415 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 604162000416 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 604162000417 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 604162000418 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 604162000419 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 604162000420 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 604162000421 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 604162000422 Transposon insertion site of 92/33 mutant 604162000423 Transposon insertion site of 24/32 mutant 604162000424 Transposon insertion site of 87/23 mutant 604162000425 Transposon insertion site of 95/23 mutant 604162000426 Transposon insertion site of 43/26 mutant 604162000427 Transposon insertion site of 57/26 mutant 604162000428 Transposon insertion site of 39/6 mutant 604162000429 Transposon insertion site of 63/11 mutant 604162000430 Transposon insertion site of 84/14 mutant 604162000431 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 604162000432 active site 604162000433 catalytic residues [active] 604162000434 metal binding site [ion binding]; metal-binding site 604162000435 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 604162000436 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 604162000437 putative active site [active] 604162000438 substrate binding site [chemical binding]; other site 604162000439 putative cosubstrate binding site; other site 604162000440 catalytic site [active] 604162000441 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 604162000442 substrate binding site [chemical binding]; other site 604162000443 Transposon insertion site of 25/1 mutant 604162000444 Transposon insertion site of 92/10 mutant 604162000445 16S rRNA methyltransferase B; Provisional; Region: PRK10901 604162000446 NusB family; Region: NusB; pfam01029 604162000447 putative RNA binding site [nucleotide binding]; other site 604162000448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162000449 S-adenosylmethionine binding site [chemical binding]; other site 604162000450 Transposon insertion site of 79/17 mutant 604162000451 Transposon insertion site of 19/43 mutant 604162000452 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 604162000453 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 604162000454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 604162000455 dimerization interface [polypeptide binding]; other site 604162000456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 604162000457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 604162000458 dimer interface [polypeptide binding]; other site 604162000459 phosphorylation site [posttranslational modification] 604162000460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 604162000461 ATP binding site [chemical binding]; other site 604162000462 Mg2+ binding site [ion binding]; other site 604162000463 G-X-G motif; other site 604162000464 Transposon insertion site of 0125/1 mutant 604162000465 Transposon insertion site of 92/36 mutant 604162000466 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 604162000467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 604162000468 active site 604162000469 phosphorylation site [posttranslational modification] 604162000470 intermolecular recognition site; other site 604162000471 dimerization interface [polypeptide binding]; other site 604162000472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 604162000473 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 604162000474 Transposon insertion site of 0126/1 mutant 604162000475 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 604162000476 DNA protecting protein DprA; Region: dprA; TIGR00732 604162000477 Transposon insertion site of 46/32 mutant 604162000478 Transposon insertion site of 64/22 mutant 604162000479 Transposon insertion site of 92/35 mutant 604162000480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Smg; COG2922 604162000481 Transposon insertion site of 47/48 mutant 604162000482 DNA topoisomerase I; Validated; Region: PRK06599 604162000483 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 604162000484 active site 604162000485 interdomain interaction site; other site 604162000486 putative metal-binding site [ion binding]; other site 604162000487 nucleotide binding site [chemical binding]; other site 604162000488 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 604162000489 domain I; other site 604162000490 DNA binding groove [nucleotide binding] 604162000491 phosphate binding site [ion binding]; other site 604162000492 domain II; other site 604162000493 domain III; other site 604162000494 nucleotide binding site [chemical binding]; other site 604162000495 catalytic site [active] 604162000496 domain IV; other site 604162000497 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 604162000498 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 604162000499 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 604162000500 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 604162000501 Transposon insertion site of 13/31 mutant 604162000502 Transposon insertion site of 69/41 mutant 604162000503 Transposon insertion site of 70/43 mutant 604162000504 Transposon insertion site of 7/37 mutant 604162000505 Transposon insertion site of 48/9 mutant 604162000506 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 604162000507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 604162000508 non-specific DNA binding site [nucleotide binding]; other site 604162000509 salt bridge; other site 604162000510 sequence-specific DNA binding site [nucleotide binding]; other site 604162000511 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 604162000512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162000513 S-adenosylmethionine binding site [chemical binding]; other site 604162000514 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 604162000515 Transposon insertion site of 89/35 mutant 604162000516 elongation factor Tu; Reviewed; Region: PRK00049 604162000517 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 604162000518 G1 box; other site 604162000519 GEF interaction site [polypeptide binding]; other site 604162000520 GTP/Mg2+ binding site [chemical binding]; other site 604162000521 Switch I region; other site 604162000522 G2 box; other site 604162000523 G3 box; other site 604162000524 Switch II region; other site 604162000525 G4 box; other site 604162000526 G5 box; other site 604162000527 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 604162000528 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 604162000529 Antibiotic Binding Site [chemical binding]; other site 604162000530 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 604162000531 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 604162000532 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 604162000533 putative homodimer interface [polypeptide binding]; other site 604162000534 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 604162000535 heterodimer interface [polypeptide binding]; other site 604162000536 homodimer interface [polypeptide binding]; other site 604162000537 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 604162000538 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 604162000539 23S rRNA interface [nucleotide binding]; other site 604162000540 L7/L12 interface [polypeptide binding]; other site 604162000541 putative thiostrepton binding site; other site 604162000542 L25 interface [polypeptide binding]; other site 604162000543 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 604162000544 mRNA/rRNA interface [nucleotide binding]; other site 604162000545 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 604162000546 23S rRNA interface [nucleotide binding]; other site 604162000547 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 604162000548 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 604162000549 core dimer interface [polypeptide binding]; other site 604162000550 peripheral dimer interface [polypeptide binding]; other site 604162000551 L10 interface [polypeptide binding]; other site 604162000552 L11 interface [polypeptide binding]; other site 604162000553 putative EF-Tu interaction site [polypeptide binding]; other site 604162000554 putative EF-G interaction site [polypeptide binding]; other site 604162000555 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 604162000556 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 604162000557 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 604162000558 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 604162000559 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 604162000560 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 604162000561 RPB3 interaction site [polypeptide binding]; other site 604162000562 RPB1 interaction site [polypeptide binding]; other site 604162000563 RPB11 interaction site [polypeptide binding]; other site 604162000564 RPB10 interaction site [polypeptide binding]; other site 604162000565 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 604162000566 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 604162000567 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 604162000568 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 604162000569 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 604162000570 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 604162000571 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 604162000572 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 604162000573 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 604162000574 DNA binding site [nucleotide binding] 604162000575 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 604162000576 Protein of unknown function (DUF560); Region: DUF560; pfam04575 604162000577 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 604162000578 S17 interaction site [polypeptide binding]; other site 604162000579 S8 interaction site; other site 604162000580 16S rRNA interaction site [nucleotide binding]; other site 604162000581 streptomycin interaction site [chemical binding]; other site 604162000582 23S rRNA interaction site [nucleotide binding]; other site 604162000583 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 604162000584 30S ribosomal protein S7; Validated; Region: PRK05302 604162000585 elongation factor G; Reviewed; Region: PRK00007 604162000586 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 604162000587 G1 box; other site 604162000588 putative GEF interaction site [polypeptide binding]; other site 604162000589 GTP/Mg2+ binding site [chemical binding]; other site 604162000590 Switch I region; other site 604162000591 G2 box; other site 604162000592 G3 box; other site 604162000593 Switch II region; other site 604162000594 G4 box; other site 604162000595 G5 box; other site 604162000596 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 604162000597 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 604162000598 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 604162000599 elongation factor Tu; Reviewed; Region: PRK00049 604162000600 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 604162000601 G1 box; other site 604162000602 GEF interaction site [polypeptide binding]; other site 604162000603 GTP/Mg2+ binding site [chemical binding]; other site 604162000604 Switch I region; other site 604162000605 G2 box; other site 604162000606 G3 box; other site 604162000607 Switch II region; other site 604162000608 G4 box; other site 604162000609 G5 box; other site 604162000610 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 604162000611 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 604162000612 Antibiotic Binding Site [chemical binding]; other site 604162000613 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 604162000614 Evidence 7 : Gene remnant; Product type e : enzyme 604162000615 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 604162000616 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 604162000617 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 604162000618 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 604162000619 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 604162000620 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 604162000621 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 604162000622 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 604162000623 putative translocon binding site; other site 604162000624 protein-rRNA interface [nucleotide binding]; other site 604162000625 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 604162000626 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 604162000627 G-X-X-G motif; other site 604162000628 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 604162000629 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 604162000630 23S rRNA interface [nucleotide binding]; other site 604162000631 5S rRNA interface [nucleotide binding]; other site 604162000632 putative antibiotic binding site [chemical binding]; other site 604162000633 L25 interface [polypeptide binding]; other site 604162000634 L27 interface [polypeptide binding]; other site 604162000635 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 604162000636 23S rRNA interface [nucleotide binding]; other site 604162000637 putative translocon interaction site; other site 604162000638 signal recognition particle (SRP54) interaction site; other site 604162000639 L23 interface [polypeptide binding]; other site 604162000640 trigger factor interaction site; other site 604162000641 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 604162000642 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 604162000643 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 604162000644 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 604162000645 RNA binding site [nucleotide binding]; other site 604162000646 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 604162000647 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 604162000648 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 604162000649 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 604162000650 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 604162000651 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 604162000652 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 604162000653 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 604162000654 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 604162000655 5S rRNA interface [nucleotide binding]; other site 604162000656 23S rRNA interface [nucleotide binding]; other site 604162000657 L5 interface [polypeptide binding]; other site 604162000658 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 604162000659 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 604162000660 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 604162000661 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 604162000662 23S rRNA binding site [nucleotide binding]; other site 604162000663 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 604162000664 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 604162000665 SecY translocase; Region: SecY; pfam00344 604162000666 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 604162000667 rRNA binding site [nucleotide binding]; other site 604162000668 predicted 30S ribosome binding site; other site 604162000669 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 604162000670 30S ribosomal protein S13; Region: bact_S13; TIGR03631 604162000671 30S ribosomal protein S11; Validated; Region: PRK05309 604162000672 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 604162000673 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 604162000674 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 604162000675 RNA binding surface [nucleotide binding]; other site 604162000676 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 604162000677 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 604162000678 alphaNTD homodimer interface [polypeptide binding]; other site 604162000679 alphaNTD - beta interaction site [polypeptide binding]; other site 604162000680 alphaNTD - beta' interaction site [polypeptide binding]; other site 604162000681 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 604162000682 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 604162000683 septum formation inhibitor; Reviewed; Region: minC; PRK04516 604162000684 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 604162000685 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 604162000686 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 604162000687 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 604162000688 Switch I; other site 604162000689 Switch II; other site 604162000690 cell division topological specificity factor MinE; Provisional; Region: PRK13989 604162000691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 604162000692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 604162000693 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 604162000694 dimerization interface [polypeptide binding]; other site 604162000695 Transposon insertion site of 40/1 mutant 604162000696 Transposon insertion site of 28/24 mutant 604162000697 Transposon insertion site of 26/19 mutant 604162000698 Transposon insertion site of 28/26 mutant 604162000699 Transposon insertion site of 60/35 mutant 604162000700 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 604162000701 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 604162000702 HIGH motif; other site 604162000703 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 604162000704 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 604162000705 active site 604162000706 KMSKS motif; other site 604162000707 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 604162000708 tRNA binding surface [nucleotide binding]; other site 604162000709 anticodon binding site; other site 604162000710 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 604162000711 zinc transporter ZupT; Provisional; Region: PRK04201 604162000712 Transposon insertion site of 46/47 mutant 604162000713 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 604162000714 hydroxyglutarate oxidase; Provisional; Region: PRK11728 604162000715 Transposon insertion site of 68/36 mutant 604162000716 Transposon insertion site of 55/37 mutant 604162000717 Transposon insertion site of 13/37 mutant 604162000718 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 604162000719 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 604162000720 Transposon insertion site of 67/9 mutant 604162000721 Transposon insertion site of 84/18 mutant 604162000722 Transposon insertion site of 54/6 mutant 604162000723 Transposon insertion site of 35/46 mutant 604162000724 Transposon insertion site of 32/29 mutant 604162000725 Transposon insertion site of 74/8 mutant 604162000726 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 604162000727 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 604162000728 active site 604162000729 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 604162000730 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 604162000731 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 604162000732 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 604162000733 trimer interface [polypeptide binding]; other site 604162000734 active site 604162000735 UDP-GlcNAc binding site [chemical binding]; other site 604162000736 lipid binding site [chemical binding]; lipid-binding site 604162000737 Transposon insertion site of 53/42 mutant 604162000738 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 604162000739 periplasmic chaperone; Provisional; Region: PRK10780 604162000740 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 604162000741 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 604162000742 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 604162000743 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 604162000744 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 604162000745 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 604162000746 Surface antigen; Region: Bac_surface_Ag; pfam01103 604162000747 zinc metallopeptidase RseP; Provisional; Region: PRK10779 604162000748 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 604162000749 active site 604162000750 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 604162000751 protein binding site [polypeptide binding]; other site 604162000752 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 604162000753 protein binding site [polypeptide binding]; other site 604162000754 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 604162000755 putative substrate binding region [chemical binding]; other site 604162000756 Transposon insertion site of 5/38 mutant 604162000757 Transposon insertion site of 21/24 mutant 604162000758 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 604162000759 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 604162000760 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 604162000761 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 604162000762 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 604162000763 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 604162000764 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 604162000765 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 604162000766 catalytic residue [active] 604162000767 putative FPP diphosphate binding site; other site 604162000768 putative FPP binding hydrophobic cleft; other site 604162000769 dimer interface [polypeptide binding]; other site 604162000770 putative IPP diphosphate binding site; other site 604162000771 ribosome recycling factor; Reviewed; Region: frr; PRK00083 604162000772 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 604162000773 hinge region; other site 604162000774 Predicted membrane protein [Function unknown]; Region: COG1289 604162000775 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 604162000776 Transposon insertion site of 61/21 mutant 604162000777 Transposon insertion site of 15/23 mutant 604162000778 Transposon insertion site of 67/41 mutant 604162000779 Transposon insertion site of 20/22 mutant 604162000780 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 604162000781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162000782 S-adenosylmethionine binding site [chemical binding]; other site 604162000783 Transposon insertion site of 20/24 mutant 604162000784 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 604162000785 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 604162000786 P-loop; other site 604162000787 Magnesium ion binding site [ion binding]; other site 604162000788 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 604162000789 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 604162000790 Magnesium ion binding site [ion binding]; other site 604162000791 Transposon insertion site of 59/31 mutant 604162000792 Transposon insertion site of 93/16 mutant 604162000793 Transposon insertion site of 34/4 mutant 604162000794 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 604162000795 RNA/DNA hybrid binding site [nucleotide binding]; other site 604162000796 active site 604162000797 Transposon insertion site of 35/38 mutant 604162000798 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 604162000799 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 604162000800 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 604162000801 Transposon insertion site of 68/3 mutant 604162000802 Transposon insertion site of 79/6 mutant 604162000803 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 604162000804 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 604162000805 Transposon insertion site of 48/45 mutant 604162000806 Transposon insertion site of 14/46 mutant 604162000807 Transposon insertion site of 17/12 mutant 604162000808 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 604162000809 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 604162000810 Transposon insertion site of 24/36 mutant 604162000811 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 604162000812 Helix-turn-helix domain; Region: HTH_38; pfam13936 604162000813 Homeodomain-like domain; Region: HTH_32; pfam13565 604162000814 Integrase core domain; Region: rve; pfam00665 604162000815 Transposon insertion site of 82/6 mutant 604162000816 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 604162000817 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 604162000818 homodimer interface [polypeptide binding]; other site 604162000819 oligonucleotide binding site [chemical binding]; other site 604162000820 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 604162000821 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 604162000822 RNA binding surface [nucleotide binding]; other site 604162000823 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 604162000824 active site 604162000825 Transposon insertion site of 1/44 mutant 604162000826 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 604162000827 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 604162000828 Transposon insertion site of 42/10 mutant 604162000829 Transposon insertion site of 33/34 mutant 604162000830 Transposon insertion site of 15/14 mutant 604162000831 Transposon insertion site of 93/3 mutant 604162000832 Transposon insertion site of 30/28 mutant 604162000833 Transposon insertion site of 49/30 mutant 604162000834 Transposon insertion site of 93/41 mutant 604162000835 Transposon insertion site of 13/47 mutant 604162000836 dihydrodipicolinate reductase; Provisional; Region: PRK00048 604162000837 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 604162000838 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 604162000839 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 604162000840 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 604162000841 Transposon insertion site of 19/44 mutant 604162000842 Transposon insertion site of 71/28 mutant 604162000843 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 604162000844 metal binding site 2 [ion binding]; metal-binding site 604162000845 putative DNA binding helix; other site 604162000846 metal binding site 1 [ion binding]; metal-binding site 604162000847 dimer interface [polypeptide binding]; other site 604162000848 structural Zn2+ binding site [ion binding]; other site 604162000849 Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360 604162000850 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 604162000851 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 604162000852 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 604162000853 ferredoxin; Provisional; Region: PRK08764 604162000854 Putative Fe-S cluster; Region: FeS; cl17515 604162000855 4Fe-4S binding domain; Region: Fer4; pfam00037 604162000856 4Fe-4S binding domain; Region: Fer4; pfam00037 604162000857 Transposon insertion site of 85/26 mutant 604162000858 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 604162000859 putative cation:proton antiport protein; Provisional; Region: PRK10669 604162000860 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 604162000861 TrkA-N domain; Region: TrkA_N; pfam02254 604162000862 TrkA-C domain; Region: TrkA_C; pfam02080 604162000863 Transposon insertion site of 80/19 mutant 604162000864 Transposon insertion site of 85/7 mutant 604162000865 Transposon insertion site of 38/37 mutant 604162000866 Transposon insertion site of 57/9 mutant 604162000867 Transposon insertion site of 9/37 mutant 604162000868 Evidence 7 : Gene remnant; Product type e : enzyme 604162000869 Transposon insertion site of 73/19 mutant 604162000870 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 604162000871 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 604162000872 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 604162000873 Transposon insertion site of 60/32 mutant 604162000874 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 604162000875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 604162000876 Mg2+ binding site [ion binding]; other site 604162000877 G-X-G motif; other site 604162000878 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 604162000879 anchoring element; other site 604162000880 dimer interface [polypeptide binding]; other site 604162000881 ATP binding site [chemical binding]; other site 604162000882 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 604162000883 active site 604162000884 putative metal-binding site [ion binding]; other site 604162000885 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 604162000886 Transposon insertion site of 3/3 mutant 604162000887 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 604162000888 Mechanosensitive ion channel; Region: MS_channel; pfam00924 604162000889 Transposon insertion site of 81/35 mutant 604162000890 Transposon insertion site of 91/38 mutant 604162000891 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 604162000892 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 604162000893 active site 604162000894 Zn binding site [ion binding]; other site 604162000895 Transposon insertion site of 31/8 mutant 604162000896 Transposon insertion site of 49/34 mutant 604162000897 Transposon insertion site of 87/31 mutant 604162000898 Predicted membrane protein [Function unknown]; Region: COG1971 604162000899 Domain of unknown function DUF; Region: DUF204; pfam02659 604162000900 Domain of unknown function DUF; Region: DUF204; pfam02659 604162000901 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 604162000902 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 604162000903 tetramer interface [polypeptide binding]; other site 604162000904 heme binding pocket [chemical binding]; other site 604162000905 NADPH binding site [chemical binding]; other site 604162000906 Transposon insertion site of 48/22 mutant 604162000907 Evidence 7 : Gene remnant; PubMedId : 9479056; Product type f : factor 604162000908 Evidence 7 : Gene remnant; PubMedId : 9479056; Product type f : factor 604162000909 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme 604162000910 Transposon insertion site of 18/48 mutant 604162000911 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme 604162000912 Transposon insertion site of 74/34 mutant 604162000913 Transposon insertion site of 62/28 mutant 604162000914 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 604162000915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 604162000916 putative substrate translocation pore; other site 604162000917 Transposon insertion site of 71/19 mutant 604162000918 Transposon insertion site of 12/14 mutant 604162000919 Transposon insertion site of 45/21 mutant 604162000920 Transposon insertion site of 14/16 mutant 604162000921 Transposon insertion site of 75/12 mutant 604162000922 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 604162000923 Sodium Bile acid symporter family; Region: SBF; cl17470 604162000924 Transposon insertion site of 85/30 mutant 604162000925 Transposon insertion site of 24/30 mutant 604162000926 Transposon insertion site of 76/22 mutant 604162000927 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 604162000928 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 604162000929 dimer interface [polypeptide binding]; other site 604162000930 active site 604162000931 acyl carrier protein; Provisional; Region: acpP; PRK00982 604162000932 Transposon insertion site of 58/22 mutant 604162000933 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 604162000934 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 604162000935 quinone interaction residues [chemical binding]; other site 604162000936 active site 604162000937 catalytic residues [active] 604162000938 FMN binding site [chemical binding]; other site 604162000939 substrate binding site [chemical binding]; other site 604162000940 Transposon insertion site of 26/32 mutant 604162000941 Transposon insertion site of 79/39 mutant 604162000942 Transposon insertion site of 55/47 mutant 604162000943 Transposon insertion site of 5/31 mutant 604162000944 Transposon insertion site of 24/16 mutant 604162000945 Transposon insertion site of 93/13 mutant 604162000946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4304 604162000947 Transposon insertion site of 89/11 mutant 604162000948 Transposon insertion site of 95/37 mutant 604162000949 Transposon insertion site of 30/6 mutant 604162000950 Transposon insertion site of 15/47 mutant 604162000951 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 604162000952 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 604162000953 metal binding triad; other site 604162000954 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 604162000955 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 604162000956 metal binding triad; other site 604162000957 Transposon insertion site of 16/29 mutant 604162000958 Transposon insertion site of 62/29 mutant 604162000959 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 604162000960 Helix-turn-helix domain; Region: HTH_38; pfam13936 604162000961 Homeodomain-like domain; Region: HTH_32; pfam13565 604162000962 Integrase core domain; Region: rve; pfam00665 604162000963 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 604162000964 Transposon insertion site of 32/32 mutant 604162000965 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 604162000966 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 604162000967 putative active site [active] 604162000968 Transposon insertion site of 47/25 mutant 604162000969 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 604162000970 Transposon insertion site of 69/10 mutant 604162000971 Transposon insertion site of 79/13 mutant 604162000972 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 604162000973 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 604162000974 DNA helicase II; Region: uvrD; TIGR01075 604162000975 Part of AAA domain; Region: AAA_19; pfam13245 604162000976 Family description; Region: UvrD_C_2; pfam13538 604162000977 Transposon insertion site of 80/33 mutant 604162000978 Transposon insertion site of 78/42 mutant 604162000979 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 604162000980 Transposon insertion site of 20/7 mutant 604162000981 Evidence 7 : Gene remnant; Product type e : enzyme 604162000982 Transposon insertion site of 9/17 mutant 604162000983 spermidine synthase; Provisional; Region: PRK03612 604162000984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 604162000985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162000986 S-adenosylmethionine binding site [chemical binding]; other site 604162000987 Transposon insertion site of 44/15 mutant 604162000988 Transposon insertion site of 20/44 mutant 604162000989 Transposon insertion site of 22/28 mutant 604162000990 Transposon insertion site of 2/23 mutant 604162000991 Transposon insertion site of 16/19 and 4/46 mutants 604162000992 Transposon insertion site of 27/2 mutant 604162000993 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 604162000994 NADH dehydrogenase subunit B; Validated; Region: PRK06411 604162000995 Transposon insertion site of 7/39 mutant 604162000996 Transposon insertion site of 39/33 mutant 604162000997 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 604162000998 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 604162000999 Transposon insertion site of 57/25 mutant 604162001000 Transposon insertion site of 29/44 mutant 604162001001 Transposon insertion site of 55/43 mutant 604162001002 NADH dehydrogenase subunit D; Validated; Region: PRK06075 604162001003 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 604162001004 NADH dehydrogenase subunit E; Validated; Region: PRK07539 604162001005 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 604162001006 putative dimer interface [polypeptide binding]; other site 604162001007 [2Fe-2S] cluster binding site [ion binding]; other site 604162001008 Transposon insertion site of 8/41 mutant 604162001009 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 604162001010 SLBB domain; Region: SLBB; pfam10531 604162001011 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 604162001012 Transposon insertion site of 23/37 mutant 604162001013 Transposon insertion site of 51/27 mutant 604162001014 Transposon insertion site of 94/41 mutant 604162001015 Transposon insertion site of 43/30 mutant 604162001016 Transposon insertion site of 74/28 mutant 604162001017 Transposon insertion site of 45/48 mutant 604162001018 Transposon insertion site of 93/9 mutant 604162001019 NADH dehydrogenase subunit G; Validated; Region: PRK09129 604162001020 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 604162001021 catalytic loop [active] 604162001022 iron binding site [ion binding]; other site 604162001023 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 604162001024 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 604162001025 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 604162001026 Transposon insertion site of 26/39 mutant 604162001027 Transposon insertion site of 16/33 mutant 604162001028 Transposon insertion site of 58/31 mutant 604162001029 Transposon insertion site of 29/45 mutant 604162001030 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 604162001031 Transposon insertion site of 51/46 mutant 604162001032 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 604162001033 4Fe-4S binding domain; Region: Fer4; cl02805 604162001034 4Fe-4S binding domain; Region: Fer4; pfam00037 604162001035 Transposon insertion site of 15/45 mutant 604162001036 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 604162001037 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 604162001038 Transposon insertion site of 54/36 mutant 604162001039 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 604162001040 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 604162001041 Fic/DOC family; Region: Fic; pfam02661 604162001042 Transposon insertion site of 88/18 mutant 604162001043 Transposon insertion site of 35/25 mutant 604162001044 Transposon insertion site of 47/43 mutant 604162001045 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 604162001046 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 604162001047 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 604162001048 Transposon insertion site of 39/25 mutant 604162001049 Transposon insertion site of 8/1 mutant 604162001050 Transposon insertion site of 85/33 mutant 604162001051 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 604162001052 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 604162001053 Transposon insertion site of 55/2 mutant 604162001054 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 604162001055 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 604162001056 Transposon insertion site of 24/35 mutant 604162001057 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 604162001058 Transposon insertion site of 94/32 mutant 604162001059 Transposon insertion site of 77/32 mutant 604162001060 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 604162001061 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 604162001062 substrate binding pocket [chemical binding]; other site 604162001063 chain length determination region; other site 604162001064 substrate-Mg2+ binding site; other site 604162001065 catalytic residues [active] 604162001066 aspartate-rich region 1; other site 604162001067 active site lid residues [active] 604162001068 aspartate-rich region 2; other site 604162001069 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 604162001070 Transposon insertion site of 42/37 mutant 604162001071 Transposon insertion site of 20/3 mutant 604162001072 GTPase RsgA; Reviewed; Region: PRK00098 604162001073 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 604162001074 RNA binding site [nucleotide binding]; other site 604162001075 homodimer interface [polypeptide binding]; other site 604162001076 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 604162001077 GTPase/Zn-binding domain interface [polypeptide binding]; other site 604162001078 GTP/Mg2+ binding site [chemical binding]; other site 604162001079 G4 box; other site 604162001080 G5 box; other site 604162001081 G1 box; other site 604162001082 Switch I region; other site 604162001083 G2 box; other site 604162001084 G3 box; other site 604162001085 Switch II region; other site 604162001086 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 604162001087 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 604162001088 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 604162001089 Walker A/P-loop; other site 604162001090 ATP binding site [chemical binding]; other site 604162001091 Q-loop/lid; other site 604162001092 ABC transporter signature motif; other site 604162001093 Walker B; other site 604162001094 D-loop; other site 604162001095 H-loop/switch region; other site 604162001096 Transposon insertion site of 85/29 mutant 604162001097 Transposon insertion site of 16/9 mutant 604162001098 Transposon insertion site of 44/3 mutant 604162001099 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 604162001100 RuvA N terminal domain; Region: RuvA_N; pfam01330 604162001101 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 604162001102 Transposon insertion site of 70/34 mutant 604162001103 Predicted membrane protein [Function unknown]; Region: COG3212 604162001104 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 604162001105 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 604162001106 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 604162001107 Transposon insertion site of 70/35 mutant 604162001108 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 604162001109 Transposon insertion site of 1/15 mutant 604162001110 Transposon insertion site of 43/14 mutant 604162001111 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 604162001112 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 604162001113 active site 604162001114 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 604162001115 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 604162001116 TAP-like protein; Region: Abhydrolase_4; pfam08386 604162001117 Transposon insertion site of 75/11 mutant 604162001118 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 604162001119 Transposon insertion site of 11/34 mutant 604162001120 Transposon insertion site of 53/48 mutant 604162001121 Transposon insertion site of 13/24 mutant 604162001122 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 604162001123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 604162001124 ATP binding site [chemical binding]; other site 604162001125 putative Mg++ binding site [ion binding]; other site 604162001126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 604162001127 nucleotide binding region [chemical binding]; other site 604162001128 ATP-binding site [chemical binding]; other site 604162001129 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 604162001130 Helicase and RNase D C-terminal; Region: HRDC; smart00341 604162001131 Helicase and RNase D C-terminal; Region: HRDC; smart00341 604162001132 Helicase and RNase D C-terminal; Region: HRDC; smart00341 604162001133 Transposon insertion site of 7/12 mutant 604162001134 Transposon insertion site of 39/48 mutant 604162001135 Transposon insertion site of 62/33 mutant 604162001136 Transposon insertion site of 72/16 mutant 604162001137 Transposon insertion site of 68/24 mutant 604162001138 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 604162001139 active site 604162001140 ribulose/triose binding site [chemical binding]; other site 604162001141 phosphate binding site [ion binding]; other site 604162001142 substrate (anthranilate) binding pocket [chemical binding]; other site 604162001143 product (indole) binding pocket [chemical binding]; other site 604162001144 Transposon insertion site of 83/13 mutant 604162001145 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 604162001146 Transposon insertion site of 17/26 mutant 604162001147 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 604162001148 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 604162001149 Transposon insertion site of 88/7 mutant 604162001150 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 604162001151 catalytic residues [active] 604162001152 hinge region; other site 604162001153 alpha helical domain; other site 604162001154 Transposon insertion site of 54/29 mutant 604162001155 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 604162001156 Phosphotransferase enzyme family; Region: APH; pfam01636 604162001157 Transposon insertion site of 60/38 mutant 604162001158 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 604162001159 Organic solvent tolerance protein; Region: OstA_C; pfam04453 604162001160 Transposon insertion site of 44/22 mutant 604162001161 SurA N-terminal domain; Region: SurA_N; pfam09312 604162001162 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 604162001163 Transposon insertion site of 39/27 mutant 604162001164 Exoribonuclease R [Transcription]; Region: VacB; COG0557 604162001165 RNB domain; Region: RNB; pfam00773 604162001166 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 604162001167 Transposon insertion site of 3/12 mutant 604162001168 Transposon insertion site of 1/23 mutant 604162001169 adenylosuccinate lyase; Provisional; Region: PRK09285 604162001170 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 604162001171 tetramer interface [polypeptide binding]; other site 604162001172 active site 604162001173 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 604162001174 Transposon insertion site of 88/4 mutant 604162001175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 604162001176 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 604162001177 putative metal binding site [ion binding]; other site 604162001178 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 604162001179 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 604162001180 DEAD_2; Region: DEAD_2; pfam06733 604162001181 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 604162001182 Transposon insertion site of 83/44 mutant 604162001183 Transposon insertion site of 83/12 mutant 604162001184 Transposon insertion site of 90/10 mutant 604162001185 Evidence 7 : Gene remnant; Product type e : enzyme 604162001186 Transposon insertion site of 19/46 mutant 604162001187 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 604162001188 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 604162001189 cofactor binding site; other site 604162001190 DNA binding site [nucleotide binding] 604162001191 substrate interaction site [chemical binding]; other site 604162001192 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 604162001193 Methyltransferase domain; Region: Methyltransf_26; pfam13659 604162001194 Transposon insertion site of 60/43 mutant 604162001195 Transposon insertion site of 96/37 mutant 604162001196 Transposon insertion site of 26/37 mutant 604162001197 Transposon insertion site of 16/16 mutant 604162001198 Transposon insertion site of 10/36 mutant 604162001199 Transposon insertion site of 19/31 mutant 604162001200 Evidence 7 : Gene remnant; Product type e : enzyme 604162001201 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 604162001202 DNA photolyase; Region: DNA_photolyase; pfam00875 604162001203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 604162001204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 604162001205 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 604162001206 putative effector binding pocket; other site 604162001207 dimerization interface [polypeptide binding]; other site 604162001208 Transposon insertion site of 0323/1 mutant 604162001209 Transposon insertion site of 14/20 mutant 604162001210 Transposon insertion site of 65/9 mutant 604162001211 Transposon insertion site of 73/16 mutant 604162001212 Predicted membrane protein [Function unknown]; Region: COG2259 604162001213 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 604162001214 dimer interface [polypeptide binding]; other site 604162001215 FMN binding site [chemical binding]; other site 604162001216 Transposon insertion site of 78/2 mutant 604162001217 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 604162001218 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 604162001219 N-terminal plug; other site 604162001220 ligand-binding site [chemical binding]; other site 604162001221 Transposon insertion site of 46/8 mutant 604162001222 Transposon insertion site of 62/3 mutant 604162001223 Transposon insertion site of 71/23 mutant 604162001224 Transposon insertion site of 25/7 mutant 604162001225 Transposon insertion site of 23/7 mutant 604162001226 Transposon insertion site of 81/4 mutant 604162001227 Transposon insertion site of 34/11 mutant 604162001228 Transposon insertion site of 74/14 mutant 604162001229 Transposon insertion site of 22/33 mutant 604162001230 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 604162001231 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 604162001232 catalytic residues [active] 604162001233 hinge region; other site 604162001234 alpha helical domain; other site 604162001235 Transposon insertion site of 35/2 mutant 604162001236 Transposon insertion site of 50/20 mutant 604162001237 Transposon insertion site of 60/8 mutant 604162001238 Transposon insertion site of 26/21 mutant 604162001239 signal recognition particle protein; Provisional; Region: PRK10867 604162001240 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 604162001241 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 604162001242 P loop; other site 604162001243 GTP binding site [chemical binding]; other site 604162001244 Signal peptide binding domain; Region: SRP_SPB; pfam02978 604162001245 Transposon insertion site of 79/29 mutant 604162001246 Transposon insertion site of 56/20 mutant 604162001247 Transposon insertion site of 82/46 mutant 604162001248 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 604162001249 Transposon insertion site of 29/12 mutant 604162001250 comEA protein; Region: comE; TIGR01259 604162001251 Helix-hairpin-helix motif; Region: HHH; pfam00633 604162001252 Transposase domain (DUF772); Region: DUF772; pfam05598 604162001253 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162001254 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 604162001255 Transposon insertion site of 71/45 mutant 604162001256 Transposon insertion site of 19/22 mutant 604162001257 Transposon insertion site of 29/13 mutant 604162001258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 604162001259 Evidence 7 : Gene remnant; Product type e : enzyme 604162001260 Transposon insertion site of 38/28 mutant 604162001261 Transposon insertion site of 32/30 mutant 604162001262 Evidence 7 : Gene remnant; Product type m : membrane component 604162001263 Transposon insertion site of 32/44 mutant 604162001264 Transposon insertion site of 72/42 mutant 604162001265 Transposon insertion site of 71/26 mutant 604162001266 Transposon insertion site of 64/35 mutant 604162001267 Transposon insertion site of 2/17 mutant 604162001268 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 604162001269 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 604162001270 Transposon insertion site of 30/11 mutant 604162001271 Transposon insertion site of 78/10 mutant 604162001272 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 604162001273 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 604162001274 folate binding site [chemical binding]; other site 604162001275 NADP+ binding site [chemical binding]; other site 604162001276 Transposon insertion site of 31/26 mutant 604162001277 Transposon insertion site of 1/9 mutant 604162001278 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 604162001279 putative active site [active] 604162001280 putative metal binding residues [ion binding]; other site 604162001281 signature motif; other site 604162001282 putative dimer interface [polypeptide binding]; other site 604162001283 putative phosphate binding site [ion binding]; other site 604162001284 Transposon insertion site of 2/48 mutant 604162001285 Predicted membrane protein [Function unknown]; Region: COG1981 604162001286 Transposon insertion site of 68/40 mutant 604162001287 Transposon insertion site of 1/22 mutant 604162001288 Transposon insertion site of 49/40 mutant 604162001289 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 604162001290 Autotransporter beta-domain; Region: Autotransporter; pfam03797 604162001291 Transposon insertion site of 85/4 mutant 604162001292 Transposon insertion site of 29/25 mutant 604162001293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 604162001294 TPR motif; other site 604162001295 Tetratricopeptide repeat; Region: TPR_16; pfam13432 604162001296 binding surface 604162001297 Protein of unknown function (DUF560); Region: DUF560; pfam04575 604162001298 Transposon insertion site of 17/13 mutant 604162001299 Transposon insertion site of 6/41 mutant 604162001300 Transposon insertion site of 60/20 mutant 604162001301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 604162001302 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 604162001303 Peptidase family M23; Region: Peptidase_M23; pfam01551 604162001304 Transposon insertion site of 6/38 mutant 604162001305 Transposon insertion site of 72/21 mutant 604162001306 hypothetical protein; Provisional; Region: PRK11212 604162001307 Transposon insertion site of 6/20 mutant 604162001308 Transposon insertion site of 4/35 mutant 604162001309 Transposon insertion site of 8/6 mutant 604162001310 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 604162001311 Transposon insertion site of 89/14 mutant 604162001312 Transposon insertion site of 13/46 mutant 604162001313 Transposon insertion site of 22/29 mutant 604162001314 Transposon insertion site of 8/13 mutant 604162001315 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 604162001316 HlyD family secretion protein; Region: HlyD_3; pfam13437 604162001317 Transposon insertion site of 23/45 mutant 604162001318 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 604162001319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 604162001320 putative substrate translocation pore; other site 604162001321 Transposon insertion site of 57/48 mutant 604162001322 Transposon insertion site of 33/39 mutant 604162001323 Transposon insertion site of 33/25 mutant 604162001324 Transposon insertion site of 1/12 mutant 604162001325 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 604162001326 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 604162001327 Transposon insertion site of 74/18 mutant 604162001328 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 604162001329 hypothetical protein; Provisional; Region: PRK09126 604162001330 Transposon insertion site of 32/1 mutant 604162001331 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 604162001332 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 604162001333 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 604162001334 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 604162001335 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 604162001336 substrate binding pocket [chemical binding]; other site 604162001337 chain length determination region; other site 604162001338 substrate-Mg2+ binding site; other site 604162001339 catalytic residues [active] 604162001340 aspartate-rich region 1; other site 604162001341 active site lid residues [active] 604162001342 aspartate-rich region 2; other site 604162001343 Predicted membrane protein [Function unknown]; Region: COG2707 604162001344 Transposon insertion site of 4/34 mutant 604162001345 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 604162001346 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 604162001347 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 604162001348 Walker A motif; other site 604162001349 ATP binding site [chemical binding]; other site 604162001350 Walker B motif; other site 604162001351 Transposon insertion site of 50/46 mutant 604162001352 Transposon insertion site of 74/32 mutant 604162001353 Transposon insertion site of 95/30 mutant 604162001354 Transposon insertion site of 41/32 mutant 604162001355 Transposon insertion site of 16/46 mutant 604162001356 Transposon insertion site of 73/27 mutant 604162001357 Transposon insertion site of 58/18 mutant 604162001358 Transposon insertion site of 70/28 mutant 604162001359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3024 604162001360 Transposon insertion site of 1/10 mutant 604162001361 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 604162001362 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 604162001363 CoA-binding site [chemical binding]; other site 604162001364 ATP-binding [chemical binding]; other site 604162001365 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 604162001366 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 604162001367 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 604162001368 Transposon insertion site of 45/16 mutant 604162001369 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 604162001370 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 604162001371 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 604162001372 Transposon insertion site of 32/46 mutant 604162001373 Transposon insertion site of 2/19 mutant 604162001374 Transposon insertion site of 25/19 mutant 604162001375 Transposon insertion site of 85/28 mutant 604162001376 Transposon insertion site of 67/33 mutant 604162001377 Transposon insertion site of 14/45 mutant 604162001378 Transposon insertion site of 39/22 mutant 604162001379 Transposon insertion site of 13/48 mutant 604162001380 Transposon insertion site of 25/28 mutant 604162001381 Transposon insertion site of 79/22 mutant 604162001382 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 604162001383 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 604162001384 active site 604162001385 dimer interface [polypeptide binding]; other site 604162001386 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 604162001387 dimer interface [polypeptide binding]; other site 604162001388 active site 604162001389 Transposon insertion site of 82/4 mutant 604162001390 Transposon insertion site of 73/15 mutant 604162001391 Transposon insertion site of 75/30 mutant 604162001392 Transposon insertion site of 10/27 mutant 604162001393 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 604162001394 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 604162001395 trimer interface [polypeptide binding]; other site 604162001396 active site 604162001397 substrate binding site [chemical binding]; other site 604162001398 CoA binding site [chemical binding]; other site 604162001399 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08690 604162001400 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 604162001401 NAD binding site [chemical binding]; other site 604162001402 homotetramer interface [polypeptide binding]; other site 604162001403 homodimer interface [polypeptide binding]; other site 604162001404 substrate binding site [chemical binding]; other site 604162001405 active site 604162001406 Transposon insertion site of 16/40 mutant 604162001407 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 604162001408 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 604162001409 homodimer interface [polypeptide binding]; other site 604162001410 substrate-cofactor binding pocket; other site 604162001411 catalytic residue [active] 604162001412 Transposon insertion site of 41/31 mutant 604162001413 Transposon insertion site of 66/34 mutant 604162001414 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 604162001415 Transposon insertion site of 53/28 mutant 604162001416 Transposon insertion site of 66/17 mutant 604162001417 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 604162001418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 604162001419 TPR motif; other site 604162001420 binding surface 604162001421 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 604162001422 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 604162001423 dimer interface [polypeptide binding]; other site 604162001424 active site 604162001425 metal binding site [ion binding]; metal-binding site 604162001426 glutathione binding site [chemical binding]; other site 604162001427 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 604162001428 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 604162001429 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 604162001430 Transposon insertion site of 51/20 mutant 604162001431 Transposon insertion site of 9/9 mutant 604162001432 Transposon insertion site of 76/6 mutant 604162001433 Transposon insertion site of 44/21 mutant 604162001434 intracellular septation protein A; Reviewed; Region: PRK00259 604162001435 Transposon insertion site of 75/47 mutant 604162001436 Transposon insertion site of 23/18 mutant 604162001437 Transposon insertion site of 87/33 mutant 604162001438 Transposon insertion site of 36/2 mutant 604162001439 Transposon insertion site of 32/22 mutant 604162001440 Transposon insertion site of 19/45 mutant 604162001441 YciI-like protein; Reviewed; Region: PRK11370 604162001442 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 604162001443 Transposon insertion site of 42/40 mutant 604162001444 Transposon insertion site of 48/46 mutant 604162001445 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 604162001446 Transposon insertion site of 46/40 mutant 604162001447 Transposon insertion site of 18/24 mutant 604162001448 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 604162001449 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 604162001450 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 604162001451 putative active site [active] 604162001452 dimerization interface [polypeptide binding]; other site 604162001453 putative tRNAtyr binding site [nucleotide binding]; other site 604162001454 Transposon insertion site of 32/9 mutant 604162001455 Transposon insertion site of 66/4 mutant 604162001456 Transposon insertion site of 1/11 mutant 604162001457 Transposon insertion site of 4/13 mutant 604162001458 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 604162001459 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 604162001460 FMN binding site [chemical binding]; other site 604162001461 active site 604162001462 catalytic residues [active] 604162001463 substrate binding site [chemical binding]; other site 604162001464 Transposon insertion site of 78/34 mutant 604162001465 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 604162001466 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 604162001467 active site 604162001468 HIGH motif; other site 604162001469 nucleotide binding site [chemical binding]; other site 604162001470 active site 604162001471 KMSKS motif; other site 604162001472 Transposon insertion site of 56/42 mutant 604162001473 Transposon insertion site of 48/39 mutant 604162001474 Transposon insertion site of 96/47 mutant 604162001475 Transposon insertion site of 48/31 mutant 604162001476 Transposon insertion site of 11/42 and 79/40 mutants 604162001477 Transposon insertion site of 11/14 mutant 604162001478 Transposon insertion site of 29/21 mutant 604162001479 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 604162001480 putative active site [active] 604162001481 transaldolase; Provisional; Region: PRK03903 604162001482 catalytic residue [active] 604162001483 Transposon insertion site of 30/12 mutant 604162001484 Transposon insertion site of 92/9 mutant 604162001485 Transposon insertion site of 1/17 mutant 604162001486 Transposon insertion site of 9/20 mutant 604162001487 Transposon insertion site of 33/7 mutant 604162001488 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 604162001489 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 604162001490 putative active site [active] 604162001491 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 604162001492 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 604162001493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 604162001494 active site 604162001495 motif I; other site 604162001496 motif II; other site 604162001497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 604162001498 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 604162001499 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 604162001500 OstA-like protein; Region: OstA; pfam03968 604162001501 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 604162001502 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 604162001503 Walker A/P-loop; other site 604162001504 ATP binding site [chemical binding]; other site 604162001505 Q-loop/lid; other site 604162001506 ABC transporter signature motif; other site 604162001507 Walker B; other site 604162001508 D-loop; other site 604162001509 H-loop/switch region; other site 604162001510 Transposon insertion site of 13/10 mutant 604162001511 Transposon insertion site of 88/20 mutant 604162001512 Transposon insertion site of 94/40 mutant 604162001513 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 604162001514 Transglycosylase; Region: Transgly; cl17702 604162001515 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 604162001516 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 604162001517 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 604162001518 shikimate binding site; other site 604162001519 NAD(P) binding site [chemical binding]; other site 604162001520 Transposon insertion site of 52/6 mutant 604162001521 Transposon insertion site of 49/7 mutant 604162001522 Transposon insertion site of 31/45 mutant 604162001523 glutamine synthetase; Provisional; Region: glnA; PRK09469 604162001524 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 604162001525 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 604162001526 muropeptide transporter; Reviewed; Region: ampG; PRK11902 604162001527 AmpG-like permease; Region: 2A0125; TIGR00901 604162001528 Transposon insertion site of 56/47 mutant 604162001529 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 604162001530 GIY-YIG motif/motif A; other site 604162001531 putative active site [active] 604162001532 putative metal binding site [ion binding]; other site 604162001533 Transposon insertion site of 27/26 mutant 604162001534 Transposon insertion site of 72/25 mutant 604162001535 Transposon insertion site of 15/2 and 64/15 mutants 604162001536 Transposon insertion site of 15/15 mutant 604162001537 Transposon insertion site of 56/22 mutant 604162001538 Transposon insertion site of 42/1 mutant 604162001539 Transposon insertion site of 7/45 mutant 604162001540 RTX iron-regulated protein FrpC; Region: FrpC; pfam06901 604162001541 Transposon insertion site of 43/5 mutant 604162001542 Transposon insertion site of 56/43 mutant 604162001543 Transposon insertion site of 23/30 mutant 604162001544 Evidence 7 : Gene remnant; Product type f : factor 604162001545 Transposon insertion site of 51/12 mutant 604162001546 Transposon insertion site of 16/30 mutant 604162001547 Transposon insertion site of 74/40 mutant 604162001548 Transposon insertion site of 1/16 mutant 604162001549 Transposon insertion site of 86/35 mutant 604162001550 Transposon insertion site of 20/13 mutant 604162001551 Transposon insertion site of 29/38 mutant 604162001552 Transposon insertion site of 29/3 mutant 604162001553 Pretoxin HINT domain; Region: PT-HINT; pfam07591 604162001554 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 604162001555 thioester formation/cholesterol transfer; other site 604162001556 protein-splicing catalytic site; other site 604162001557 Transposon insertion site of 69/17 mutant 604162001558 Transposon insertion site of 52/20 mutant 604162001559 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 604162001560 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 604162001561 Transposon insertion site of 77/22 mutant 604162001562 Transposon insertion site of 2/7 mutant 604162001563 Transposon insertion site of 28/43 mutant 604162001564 Transposon insertion site of 93/22 mutant 604162001565 Transposon insertion site of 10/32 mutant 604162001566 Transposon insertion site of 88/33 mutant 604162001567 Transposon insertion site of 4/42 mutant 604162001568 Transposon insertion site of 77/27 mutant 604162001569 Transposon insertion site of 38/24 mutant 604162001570 Transposon insertion site of 67/1 mutant 604162001571 Transposon insertion site of 86/19 mutant 604162001572 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 604162001573 Transposon insertion site of 44/13 mutant 604162001574 Transposon insertion site of 49/16 mutant 604162001575 Transposon insertion site of 58/33 mutant 604162001576 Transposon insertion site of 44/29 mutant 604162001577 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 604162001578 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 604162001579 Transposon insertion site of 56/33 mutant 604162001580 Transposon insertion site of 15/27 mutant 604162001581 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 604162001582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 604162001583 FeS/SAM binding site; other site 604162001584 HemN C-terminal domain; Region: HemN_C; pfam06969 604162001585 Transposon insertion site of 76/42 mutant 604162001586 Transposon insertion site of 86/21 mutant 604162001587 Transposon insertion site of 72/4 mutant 604162001588 Transposon insertion site of 21/29 mutant 604162001589 Transposon insertion site of 60/5 mutant 604162001590 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 604162001591 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 604162001592 ligand binding site [chemical binding]; other site 604162001593 flexible hinge region; other site 604162001594 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 604162001595 putative switch regulator; other site 604162001596 non-specific DNA interactions [nucleotide binding]; other site 604162001597 DNA binding site [nucleotide binding] 604162001598 sequence specific DNA binding site [nucleotide binding]; other site 604162001599 putative cAMP binding site [chemical binding]; other site 604162001600 Transposon insertion site of 39/44 mutant 604162001601 Transposon insertion site of 12/47 mutant 604162001602 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 604162001603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 604162001604 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 604162001605 substrate binding site [chemical binding]; other site 604162001606 dimerization interface [polypeptide binding]; other site 604162001607 Transposon insertion site of 42/36 mutant 604162001608 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 604162001609 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 604162001610 ligand binding site [chemical binding]; other site 604162001611 Transposon insertion site of 89/30 mutant 604162001612 Transposon insertion site of 64/29 mutant 604162001613 Transposon insertion site of 42/18 mutant 604162001614 Transposon insertion site of 52/5 mutant 604162001615 thiamine-monophosphate kinase; Region: thiL; TIGR01379 604162001616 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 604162001617 ATP binding site [chemical binding]; other site 604162001618 dimerization interface [polypeptide binding]; other site 604162001619 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 604162001620 tetramer interfaces [polypeptide binding]; other site 604162001621 binuclear metal-binding site [ion binding]; other site 604162001622 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 604162001623 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 604162001624 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 604162001625 ABC transporter; Region: ABC_tran_2; pfam12848 604162001626 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 604162001627 Transposon insertion site of 43/16 mutant 604162001628 Transposon insertion site of 90/44 mutant 604162001629 Transposon insertion site of 14/14 mutant 604162001630 Transposon insertion site of 38/23 mutant 604162001631 Transposon insertion site of 1/19 mutant 604162001632 Transposon insertion site of 5/18 mutant 604162001633 Transposon insertion site of 9/30 mutant 604162001634 Transposon insertion site of 10/30 mutant 604162001635 Transposon insertion site of 48/37 mutant 604162001636 Transposon insertion site of 35/12 mutant 604162001637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 604162001638 putative substrate translocation pore; other site 604162001639 Major Facilitator Superfamily; Region: MFS_1; pfam07690 604162001640 Transposon insertion site of 37/47 mutant 604162001641 Transposon insertion site of 86/45 mutant 604162001642 Transposon insertion site of 70/40 mutant 604162001643 Transposon insertion site of 40/15 mutant 604162001644 Transposon insertion site of 52/24 mutant 604162001645 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 604162001646 active site 604162001647 catalytic residues [active] 604162001648 Transposon insertion site of 77/42 mutant 604162001649 Transposon insertion site of 11/10 mutant 604162001650 Transposon insertion site of 12/30 mutant 604162001651 Transposon insertion site of 64/32 mutant 604162001652 maltose phosphorylase; Provisional; Region: PRK13807 604162001653 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 604162001654 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 604162001655 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 604162001656 Transposon insertion site of 5/34 mutant 604162001657 beta-phosphoglucomutase; Region: bPGM; TIGR01990 604162001658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 604162001659 motif II; other site 604162001660 Transposon insertion site of 20/32 mutant 604162001661 L-aspartate oxidase; Provisional; Region: PRK06175 604162001662 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 604162001663 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 604162001664 Transposon insertion site of 2/4 mutant 604162001665 Transposon insertion site of 47/24 mutant 604162001666 Transposon insertion site of 8/11 mutant 604162001667 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 604162001668 quinolinate synthetase; Provisional; Region: PRK09375 604162001669 Transposon insertion site of 9/44 mutant 604162001670 Transposon insertion site of 56/24 mutant 604162001671 Transposon insertion site of 82/33 mutant 604162001672 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 604162001673 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 604162001674 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 604162001675 dimerization interface [polypeptide binding]; other site 604162001676 active site 604162001677 Transposon insertion site of 69/35 mutant 604162001678 Transposon insertion site of 47/29 mutant 604162001679 Transposon insertion site of 4/27 mutant 604162001680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 604162001681 dimerization interface [polypeptide binding]; other site 604162001682 putative DNA binding site [nucleotide binding]; other site 604162001683 putative Zn2+ binding site [ion binding]; other site 604162001684 Transposon insertion site of 0433/1 mutant 604162001685 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 604162001686 putative catalytic site [active] 604162001687 putative phosphate binding site [ion binding]; other site 604162001688 active site 604162001689 metal binding site A [ion binding]; metal-binding site 604162001690 DNA binding site [nucleotide binding] 604162001691 putative AP binding site [nucleotide binding]; other site 604162001692 putative metal binding site B [ion binding]; other site 604162001693 Transposon insertion site of 86/31 mutant 604162001694 Transposon insertion site of 5/2 mutant 604162001695 Transposon insertion site of 41/10 mutant 604162001696 Transposon insertion site of 17/16 mutant 604162001697 Transposon insertion site of 19/32 mutant 604162001698 Transposon insertion site of 63/46 mutant 604162001699 Transposon insertion site of 96/21 mutant 604162001700 Transposon insertion site of 79/46 mutant 604162001701 Transposon insertion site of 40/30 mutant 604162001702 Transposon insertion site of 59/37 mutant 604162001703 Transposon insertion site of 47/33 mutant 604162001704 Transposon insertion site of 77/15 mutant 604162001705 Transposon insertion site of 39/14 mutant 604162001706 Evidence 7 : Gene remnant; Product type e : enzyme 604162001707 Transposon insertion site of 95/41 mutant 604162001708 Transposon insertion site of 40/24 mutant 604162001709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 604162001710 AAA domain; Region: AAA_21; pfam13304 604162001711 Q-loop/lid; other site 604162001712 ABC transporter signature motif; other site 604162001713 Walker B; other site 604162001714 D-loop; other site 604162001715 H-loop/switch region; other site 604162001716 Evidence 7 : Gene remnant; Product type e : enzyme 604162001717 Transposon insertion site of 59/14 mutant 604162001718 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 604162001719 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 604162001720 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 604162001721 Glutamate binding site [chemical binding]; other site 604162001722 NAD binding site [chemical binding]; other site 604162001723 catalytic residues [active] 604162001724 Transposon insertion site of 53/5 mutant 604162001725 Transposon insertion site of 16/10 mutant 604162001726 Transposon insertion site of 13/42 mutant 604162001727 Transposon insertion site of 89/21 mutant 604162001728 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 604162001729 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 604162001730 Na binding site [ion binding]; other site 604162001731 Transposon insertion site of 51/19 mutant 604162001732 Transposon insertion site of 30/33 mutant 604162001733 Transposon insertion site of 52/32 mutant 604162001734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 604162001735 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 604162001736 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 604162001737 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 604162001738 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 604162001739 cell division protein FtsN; Region: ftsN; TIGR02223 604162001740 Sporulation related domain; Region: SPOR; pfam05036 604162001741 Transposon insertion site of 18/5 mutant 604162001742 Transposon insertion site of 64/38 mutant 604162001743 Transposon insertion site of 40/41 mutant 604162001744 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 604162001745 catalytic residues [active] 604162001746 hinge region; other site 604162001747 alpha helical domain; other site 604162001748 Transposon insertion site of 24/13 mutant 604162001749 Transposon insertion site of 21/32 mutant 604162001750 Transposon insertion site of 2/31 mutant 604162001751 Transposon insertion site of 36/43 mutant 604162001752 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 604162001753 Transposon insertion site of 51/34 mutant 604162001754 Uncharacterized conserved protein [Function unknown]; Region: COG1565 604162001755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 604162001756 Transposon insertion site of 13/2 mutant 604162001757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 604162001758 MraZ protein; Region: MraZ; pfam02381 604162001759 MraZ protein; Region: MraZ; pfam02381 604162001760 MraW methylase family; Region: Methyltransf_5; cl17771 604162001761 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 604162001762 Transposon insertion site of 51/30 mutant 604162001763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 604162001764 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 604162001765 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 604162001766 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 604162001767 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 604162001768 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 604162001769 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 604162001770 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 604162001771 Transposon insertion site of 57/14 mutant 604162001772 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 604162001773 Sulfatase; Region: Sulfatase; pfam00884 604162001774 Transposon insertion site of 3/4 mutant 604162001775 Transposon insertion site of 34/37 mutant 604162001776 Transposon insertion site of 63/6 mutant 604162001777 Transposon insertion site of 45/42 mutant 604162001778 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 604162001779 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 604162001780 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 604162001781 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 604162001782 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 604162001783 Transposon insertion site of 10/28 mutant 604162001784 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 604162001785 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 604162001786 Mg++ binding site [ion binding]; other site 604162001787 putative catalytic motif [active] 604162001788 putative substrate binding site [chemical binding]; other site 604162001789 Transposon insertion site of 38/15 mutant 604162001790 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 604162001791 Sel1-like repeats; Region: SEL1; smart00671 604162001792 Sel1-like repeats; Region: SEL1; smart00671 604162001793 Transposon insertion site of 60/19 mutant 604162001794 Transposon insertion site of 36/4 mutant 604162001795 Transposon insertion site of 81/45 mutant 604162001796 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04308 604162001797 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 604162001798 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 604162001799 Transposon insertion site of 56/21 mutant 604162001800 cell division protein FtsW; Region: ftsW; TIGR02614 604162001801 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 604162001802 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 604162001803 active site 604162001804 homodimer interface [polypeptide binding]; other site 604162001805 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 604162001806 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 604162001807 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 604162001808 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 604162001809 Transposon insertion site of 48/2 mutant 604162001810 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 604162001811 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 604162001812 ATP-grasp domain; Region: ATP-grasp_4; cl17255 604162001813 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 604162001814 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 604162001815 Cell division protein FtsQ; Region: FtsQ; pfam03799 604162001816 cell division protein FtsA; Region: ftsA; TIGR01174 604162001817 Cell division protein FtsA; Region: FtsA; smart00842 604162001818 Cell division protein FtsA; Region: FtsA; pfam14450 604162001819 Transposon insertion site of 64/31 mutant 604162001820 Transposon insertion site of 3/6 mutant 604162001821 cell division protein FtsZ; Validated; Region: PRK09330 604162001822 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 604162001823 nucleotide binding site [chemical binding]; other site 604162001824 SulA interaction site; other site 604162001825 Transposon insertion site of 62/13 mutant 604162001826 Transposon insertion site of 52/42 mutant 604162001827 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 604162001828 Transposon insertion site of 25/24 mutant 604162001829 Transposon insertion site of 87/41 mutant 604162001830 Transposon insertion site of 92/19 mutant 604162001831 Transposon insertion site of 30/24 mutant 604162001832 Transposon insertion site of 70/18 mutant 604162001833 Transposon insertion site of 18/34 mutant 604162001834 Transposon insertion site of 36/33 mutant 604162001835 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 604162001836 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 604162001837 tetramer interface [polypeptide binding]; other site 604162001838 active site 604162001839 Mg2+/Mn2+ binding site [ion binding]; other site 604162001840 Transposon insertion site of 87/10 mutant 604162001841 Transposon insertion site of 26/1 mutant 604162001842 Transposon insertion site of 10/23 mutant 604162001843 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 604162001844 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 604162001845 dimer interface [polypeptide binding]; other site 604162001846 active site 604162001847 citrylCoA binding site [chemical binding]; other site 604162001848 oxalacetate/citrate binding site [chemical binding]; other site 604162001849 coenzyme A binding site [chemical binding]; other site 604162001850 catalytic triad [active] 604162001851 Transposon insertion site of 91/29 mutant 604162001852 Transposon insertion site of 96/30 mutant 604162001853 Transposon insertion site of 29/48 mutant 604162001854 Transposon insertion site of 62/39 mutant 604162001855 Transposon insertion site of 8/28 mutant 604162001856 Transposon insertion site of 50/15 mutant 604162001857 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 604162001858 Fatty acid desaturase; Region: FA_desaturase; pfam00487 604162001859 putative di-iron ligands [ion binding]; other site 604162001860 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 604162001861 Transposon insertion site of 80/41 mutant 604162001862 Transposon insertion site of 95/46 mutant 604162001863 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 604162001864 EamA-like transporter family; Region: EamA; pfam00892 604162001865 Transposon insertion site of 79/31 mutant 604162001866 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 604162001867 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 604162001868 substrate binding site [chemical binding]; other site 604162001869 ligand binding site [chemical binding]; other site 604162001870 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 604162001871 substrate binding site [chemical binding]; other site 604162001872 Transposon insertion site of 70/39 mutant 604162001873 Transposon insertion site of 73/2 mutant 604162001874 Transposon insertion site of 14/5 mutant 604162001875 Transposon insertion site of 49/10 mutant 604162001876 Transposon insertion site of 59/10 mutant 604162001877 Transposon insertion site of 23/41 mutant 604162001878 Transposon insertion site of 87/12 mutant 604162001879 Transposon insertion site of 38/25 mutant 604162001880 Transposon insertion site of 30/8 mutant 604162001881 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 604162001882 Transposon insertion site of 81/48 mutant 604162001883 propionate/acetate kinase; Provisional; Region: PRK12379 604162001884 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 604162001885 Transposon insertion site of 44/17 mutant 604162001886 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 604162001887 Transcriptional regulator; Region: Rrf2; cl17282 604162001888 Rrf2 family protein; Region: rrf2_super; TIGR00738 604162001889 Transposon insertion site of 41/12 mutant 604162001890 Transposon insertion site of 63/25 mutant 604162001891 Transposon insertion site of 11/18 mutant 604162001892 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 604162001893 Transposon insertion site of 79/45 mutant 604162001894 Transposon insertion site of 88/40 mutant 604162001895 Transposon insertion site of 77/48 mutant 604162001896 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 604162001897 prephenate dehydrogenase; Validated; Region: PRK08507 604162001898 Predicted amidohydrolase [General function prediction only]; Region: COG0388 604162001899 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 604162001900 putative active site [active] 604162001901 catalytic triad [active] 604162001902 dimer interface [polypeptide binding]; other site 604162001903 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type m : membrane component 604162001904 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type m : membrane component 604162001905 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 604162001906 Helix-turn-helix domain; Region: HTH_38; pfam13936 604162001907 Homeodomain-like domain; Region: HTH_32; pfam13565 604162001908 Integrase core domain; Region: rve; pfam00665 604162001909 Transposon insertion site of 63/47 mutant 604162001910 Transposon insertion site of 8/37 mutant 604162001911 Transposon insertion site of 45/9 mutant 604162001912 EamA-like transporter family; Region: EamA; pfam00892 604162001913 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 604162001914 EamA-like transporter family; Region: EamA; pfam00892 604162001915 Transposon insertion site of 81/42 mutant 604162001916 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 604162001917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 604162001918 putative substrate translocation pore; other site 604162001919 Transposon insertion site of 95/33 mutant 604162001920 chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807 604162001921 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 604162001922 Prephenate dehydratase; Region: PDT; pfam00800 604162001923 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 604162001924 putative L-Phe binding site [chemical binding]; other site 604162001925 Recombination protein O N terminal; Region: RecO_N; pfam11967 604162001926 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 604162001927 Recombination protein O C terminal; Region: RecO_C; pfam02565 604162001928 Transposon insertion site of 16/44 mutant 604162001929 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 604162001930 active site 604162001931 hydrophilic channel; other site 604162001932 dimerization interface [polypeptide binding]; other site 604162001933 catalytic residues [active] 604162001934 active site lid [active] 604162001935 Transposon insertion site of 37/44 mutant 604162001936 Transposon insertion site of 45/6 mutant 604162001937 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 604162001938 active site 604162001939 iron coordination sites [ion binding]; other site 604162001940 substrate binding pocket [chemical binding]; other site 604162001941 Transposon insertion site of 49/27 mutant 604162001942 Transposon insertion site of 55/39 mutant 604162001943 Transposon insertion site of 49/21 mutant 604162001944 Transposon insertion site of 40/19 mutant 604162001945 Transposon insertion site of 56/23 mutant 604162001946 Transposon insertion site of 41/34 mutant 604162001947 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 604162001948 Transposon insertion site of 71/5 mutant 604162001949 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 604162001950 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 604162001951 active site 604162001952 8-oxo-dGMP binding site [chemical binding]; other site 604162001953 nudix motif; other site 604162001954 metal binding site [ion binding]; metal-binding site 604162001955 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 604162001956 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 604162001957 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 604162001958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 604162001959 Transposon insertion site of 18/41 mutant 604162001960 Fic family protein [Function unknown]; Region: COG3177 604162001961 Fic/DOC family; Region: Fic; pfam02661 604162001962 Transposon insertion site of 7/21 mutant 604162001963 Transposon insertion site of 91/36 mutant 604162001964 Transposon insertion site of 78/38 mutant 604162001965 Transposon insertion site of 15/8 mutant 604162001966 AMIN domain; Region: AMIN; pfam11741 604162001967 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 604162001968 active site 604162001969 metal binding site [ion binding]; metal-binding site 604162001970 Transposon insertion site of 78/47 mutant 604162001971 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 604162001972 glutamate racemase; Provisional; Region: PRK00865 604162001973 Fic family protein [Function unknown]; Region: COG3177 604162001974 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 604162001975 Fic/DOC family; Region: Fic; pfam02661 604162001976 Transposon insertion site of 68/26 mutant 604162001977 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 604162001978 Transposon insertion site of 71/33 mutant 604162001979 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 604162001980 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 604162001981 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 604162001982 Transposon insertion site of 16/27 mutant 604162001983 Transposon insertion site of 44/33 mutant 604162001984 Transposon insertion site of 45/47 mutant 604162001985 Transposon insertion site of 48/33 mutant 604162001986 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 604162001987 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 604162001988 Transposon insertion site of 77/1 mutant 604162001989 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 604162001990 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 604162001991 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 604162001992 dimerization interface [polypeptide binding]; other site 604162001993 substrate binding site [chemical binding]; other site 604162001994 active site 604162001995 calcium binding site [ion binding]; other site 604162001996 Transposon insertion site of 3/38 mutant 604162001997 Transposon insertion site of 86/34 mutant 604162001998 Uncharacterized conserved protein [Function unknown]; Region: COG2928 604162001999 Transposon insertion site of 92/18 mutant 604162002000 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 604162002001 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 604162002002 dimer interface [polypeptide binding]; other site 604162002003 anticodon binding site; other site 604162002004 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 604162002005 homodimer interface [polypeptide binding]; other site 604162002006 motif 1; other site 604162002007 active site 604162002008 motif 2; other site 604162002009 GAD domain; Region: GAD; pfam02938 604162002010 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 604162002011 motif 3; other site 604162002012 Transposon insertion site of 21/48 mutant 604162002013 Transposon insertion site of 18/7 mutant 604162002014 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 604162002015 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 604162002016 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 604162002017 dimer interface [polypeptide binding]; other site 604162002018 active site 604162002019 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 604162002020 catalytic residues [active] 604162002021 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 604162002022 Transposon insertion site of 88/8 mutant 604162002023 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 604162002024 agmatinase; Region: agmatinase; TIGR01230 604162002025 oligomer interface [polypeptide binding]; other site 604162002026 putative active site [active] 604162002027 Mn binding site [ion binding]; other site 604162002028 Transposon insertion site of 31/30 mutant 604162002029 Transposon insertion site of 1/46 mutant 604162002030 Transposon insertion site of 34/31 mutant 604162002031 Transposon insertion site of 70/26 mutant 604162002032 Transposon insertion site of 59/21 mutant 604162002033 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 604162002034 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 604162002035 transmembrane helices; other site 604162002036 Transposon insertion site of 72/37 mutant 604162002037 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 604162002038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 604162002039 Transposon insertion site of 26/31 mutant 604162002040 Transposon insertion site of 94/7 mutant 604162002041 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 604162002042 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 604162002043 substrate-cofactor binding pocket; other site 604162002044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162002045 catalytic residue [active] 604162002046 Transposon insertion site of 35/3 mutant 604162002047 Protein of unknown function (DUF452); Region: DUF452; cl01062 604162002048 Transposon insertion site of 43/12 mutant 604162002049 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 604162002050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162002051 S-adenosylmethionine binding site [chemical binding]; other site 604162002052 Transposon insertion site of 69/36 mutant 604162002053 Transposon insertion site of 72/36 mutant 604162002054 Transposon insertion site of 21/18 mutant 604162002055 Transposon insertion site of 52/11 mutant 604162002056 Transposon insertion site of 64/12 mutant 604162002057 Transposon insertion site of 24/3 mutant 604162002058 Transposon insertion site of 50/18 mutant 604162002059 Transposon insertion site of 49/17 mutant 604162002060 Transposon insertion site of 54/31 mutant 604162002061 Transposon insertion site of 5/10 mutant 604162002062 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 604162002063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 604162002064 active site 604162002065 phosphorylation site [posttranslational modification] 604162002066 intermolecular recognition site; other site 604162002067 dimerization interface [polypeptide binding]; other site 604162002068 Transposon insertion site of 25/33 mutant 604162002069 Transposon insertion site of 20/5 mutant 604162002070 Transposon insertion site of 3/10 mutant 604162002071 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 604162002072 G1 box; other site 604162002073 GTP/Mg2+ binding site [chemical binding]; other site 604162002074 G2 box; other site 604162002075 Switch I region; other site 604162002076 G3 box; other site 604162002077 Switch II region; other site 604162002078 G4 box; other site 604162002079 G5 box; other site 604162002080 Transposon insertion site of 56/35 mutant 604162002081 Transposon insertion site of 48/29 mutant 604162002082 Transposon insertion site of 12/24 mutant 604162002083 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 604162002084 Evidence 7 : Gene remnant; PubMedId : 16769696; Product type f : factor 604162002085 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16769696; Product type pe : putative enzyme' 604162002086 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16769696; Product type pe : putative enzyme' 604162002087 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 604162002088 Helix-turn-helix domain; Region: HTH_38; pfam13936 604162002089 Homeodomain-like domain; Region: HTH_32; pfam13565 604162002090 Integrase core domain; Region: rve; pfam00665 604162002091 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162002092 Transposon insertion site of 49/8 mutant 604162002093 Transposon insertion site of 17/14 mutant 604162002094 Transposon insertion site of 52/45 mutant 604162002095 Transposon insertion site of 27/21 mutant 604162002096 Transposon insertion site of 41/47 mutant 604162002097 Evidence 4 : Homologs of previously reported genes of unknown function 604162002098 Evidence 4 : Homologs of previously reported genes of unknown function 604162002099 Transposon insertion site of 77/8 mutant 604162002100 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162002101 Transposon insertion site of 37/9 mutant 604162002102 Transposon insertion site of 90/4 mutant 604162002103 Transposon insertion site of 28/13 mutant 604162002104 Transposon insertion site of 73/8 mutant 604162002105 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 604162002106 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162002107 Transposon insertion site of 59/26 mutant 604162002108 Transposon insertion site of 19/40 mutant 604162002109 Transposon insertion site of 66/10 mutant 604162002110 Transposon insertion site of 72/23 mutant 604162002111 'Evidence 7 : Gene remnant; PubMedId : 15546669,16472308, 17873034; Product type f : factor' 604162002112 Transposon insertion site of 90/21 mutant 604162002113 Transposon insertion site of 8/14 mutant 604162002114 Transposon insertion site of 33/43 mutant 604162002115 Transposon insertion site of 3/9 mutant 604162002116 Transposon insertion site of 64/24 mutant 604162002117 Transposon insertion site of 50/19 mutant 604162002118 Transposon insertion site of 81/15 mutant 604162002119 Transposon insertion site of 12/1 mutant 604162002120 Transposon insertion site of 11/1 mutant 604162002121 Transposon insertion site of 73/3 mutant 604162002122 Transposon insertion site of 89/28 mutant 604162002123 Transposon insertion site of 83/8 mutant 604162002124 Transposase domain (DUF772); Region: DUF772; pfam05598 604162002125 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162002126 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 604162002127 'Evidence 7 : Gene remnant; PubMedId : 15546669,16472308, 17873034; Product type f : factor' 604162002128 Transposase IS200 like; Region: Y1_Tnp; pfam01797 604162002129 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002130 Transposon insertion site of 27/47 mutant 604162002131 Transposon insertion site of 3/18 mutant 604162002132 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002133 Transposon insertion site of 19/38 mutant 604162002134 Initiator Replication protein; Region: Rep_3; pfam01051 604162002135 Transposon insertion site of 74/39 mutant 604162002136 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 604162002137 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 604162002138 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 604162002139 Transposon insertion site of 87/39 mutant 604162002140 haemagglutination activity domain; Region: Haemagg_act; pfam05860 604162002141 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 604162002142 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 604162002143 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 604162002144 Transposon insertion site of 33/40 mutant 604162002145 Transposon insertion site of 61/45 mutant 604162002146 Transposon insertion site of 47/16 mutant 604162002147 Transposon insertion site of 36/25 mutant 604162002148 Transposon insertion site of 35/7 mutant 604162002149 Transposon insertion site of 20/27 mutant 604162002150 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 604162002151 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 604162002152 Evidence 7 : Gene remnant; PubMedId : 16472308; Product type pf : putative factor 604162002153 Transposase domain (DUF772); Region: DUF772; pfam05598 604162002154 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162002155 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 604162002156 Evidence 7 : Gene remnant; PubMedId : 16472308; Product type pf : putative factor 604162002157 Transposon insertion site of 87/26 mutant 604162002158 Transposon insertion site of 3/19 mutant 604162002159 Transposon insertion site of 2/1 mutant 604162002160 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162002161 Transposon insertion site of 22/11 mutant 604162002162 Transposon insertion site of 10/21 mutant 604162002163 Transposon insertion site of 46/46 mutant 604162002164 Transposon insertion site of 41/11 mutant 604162002165 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162002166 Transposon insertion site of 91/33 mutant 604162002167 Transposon insertion site of 86/48 mutant 604162002168 Transposon insertion site of 60/28 mutant 604162002169 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162002170 Transposon insertion site of 77/31 mutant 604162002171 Transposon insertion site of 68/22 mutant 604162002172 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162002173 Transposon insertion site of 7/42 mutant 604162002174 Transposon insertion site of 83/35 mutant 604162002175 Transposon insertion site of 78/17 mutant 604162002176 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 604162002177 metal binding triad [ion binding]; metal-binding site 604162002178 Fic/DOC family; Region: Fic; pfam02661 604162002179 Transposon insertion site of 68/33 mutant 604162002180 Evidence 7 : Gene remnant; Product type f : factor 604162002181 Evidence 7 : Gene remnant; Product type e : enzyme 604162002182 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 604162002183 haemagglutination activity domain; Region: Haemagg_act; pfam05860 604162002184 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 604162002185 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 604162002186 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 604162002187 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 604162002188 Transposon insertion site of 68/48 mutant 604162002189 Transposon insertion site of 67/27 mutant 604162002190 Transposon insertion site of 76/21 mutant 604162002191 conjugal transfer protein TraV; Provisional; Region: PRK13733 604162002192 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162002193 Transposon insertion site of 27/33 mutant 604162002194 Transposon insertion site of 30/22 mutant 604162002195 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 604162002196 Helix-turn-helix domain; Region: HTH_38; pfam13936 604162002197 Homeodomain-like domain; Region: HTH_32; pfam13565 604162002198 Integrase core domain; Region: rve; pfam00665 604162002199 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162002200 ACP:hemolysin acyltransferase (hemolysin-activating protein) [Posttranslational modification, protein turnover, chaperones]; Region: HlyC; COG2994 604162002201 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 604162002202 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 604162002203 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 604162002204 Transposon insertion site of 33/36 mutant 604162002205 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 604162002206 HipA N-terminal domain; Region: Couple_hipA; pfam13657 604162002207 HipA-like N-terminal domain; Region: HipA_N; pfam07805 604162002208 HipA-like C-terminal domain; Region: HipA_C; pfam07804 604162002209 Transposon insertion site of 30/35 mutant 604162002210 oxidoreductase; Region: PLN02991 604162002211 Fic family protein [Function unknown]; Region: COG3177 604162002212 Fic/DOC family; Region: Fic; pfam02661 604162002213 Transposon insertion site of 9/10 mutant 604162002214 Transposon insertion site of 31/28 mutant 604162002215 Evidence 7 : Gene remnant; Product type e : enzyme 604162002216 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 604162002217 Transposon insertion site of 21/46 mutant 604162002218 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 604162002219 Helix-turn-helix domain; Region: HTH_38; pfam13936 604162002220 Homeodomain-like domain; Region: HTH_32; pfam13565 604162002221 Integrase core domain; Region: rve; pfam00665 604162002222 Evidence 7 : Gene remnant; Product type e : enzyme 604162002223 Transposon insertion site of 12/10 mutant 604162002224 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002225 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002226 Transposon insertion site of 32/5 mutant 604162002227 Transposon insertion site of 51/29 mutant 604162002228 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 604162002229 Transposon insertion site of 29/15 mutant 604162002230 Transposon insertion site of 87/40 mutant 604162002231 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 604162002232 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 604162002233 HlyD family secretion protein; Region: HlyD_3; pfam13437 604162002234 Transposon insertion site of 6/42 mutant 604162002235 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 604162002236 Transposon insertion site of 28/3 mutant 604162002237 Transposon insertion site of 53/26 mutant 604162002238 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002239 Transposon insertion site of 78/39 mutant 604162002240 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002241 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 604162002242 HD domain; Region: HD_4; pfam13328 604162002243 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 604162002244 synthetase active site [active] 604162002245 NTP binding site [chemical binding]; other site 604162002246 metal binding site [ion binding]; metal-binding site 604162002247 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 604162002248 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 604162002249 Transposon insertion site of 67/2 mutant 604162002250 Transposon insertion site of 17/23 mutant 604162002251 Glutaredoxin 2 [Posttranslational modification, protein turnover, chaperones]; Region: GrxB; COG2999 604162002252 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 604162002253 C-terminal domain interface [polypeptide binding]; other site 604162002254 GSH binding site (G-site) [chemical binding]; other site 604162002255 catalytic residues [active] 604162002256 putative dimer interface [polypeptide binding]; other site 604162002257 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 604162002258 N-terminal domain interface [polypeptide binding]; other site 604162002259 Transposon insertion site of 64/40 mutant 604162002260 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 604162002261 Transposon insertion site of 55/45 mutant 604162002262 Transposon insertion site of 81/13 mutant 604162002263 Transposon insertion site of 5/23 mutant 604162002264 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 604162002265 Peptidase family M50; Region: Peptidase_M50; pfam02163 604162002266 active site 604162002267 putative substrate binding region [chemical binding]; other site 604162002268 Transposon insertion site of 41/3 mutant 604162002269 Transposon insertion site of 90/23 mutant 604162002270 Transposon insertion site of 50/14 mutant 604162002271 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 604162002272 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 604162002273 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 604162002274 Transposon insertion site of 37/33 mutant 604162002275 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 604162002276 TolR protein; Region: tolR; TIGR02801 604162002277 Transposon insertion site of 85/3 mutant 604162002278 Transposon insertion site of 59/1 mutant 604162002279 TIGR01244 family protein; Region: TIGR01244 604162002280 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 604162002281 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 604162002282 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 604162002283 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 604162002284 protein binding site [polypeptide binding]; other site 604162002285 Transposon insertion site of 52/47 mutant 604162002286 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 604162002287 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 604162002288 Low-spin heme binding site [chemical binding]; other site 604162002289 Putative water exit pathway; other site 604162002290 Binuclear center (active site) [active] 604162002291 Putative proton exit pathway; other site 604162002292 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 604162002293 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 604162002294 Cbb3-type cytochrome oxidase, subunit 3 [Posttranslational modification, protein turnover, chaperones]; Region: CcoQ; COG4736 604162002295 Transposon insertion site of 96/38 mutant 604162002296 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 604162002297 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 604162002298 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 604162002299 Evidence 7 : Gene remnant; Product type c : carrier 604162002300 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 604162002301 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 604162002302 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 604162002303 Transposon insertion site of 27/20 mutant 604162002304 Transposon insertion site of 94/9 mutant 604162002305 Transposon insertion site of 55/5 mutant 604162002306 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 604162002307 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 604162002308 Transposon insertion site of 62/21 mutant 604162002309 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 604162002310 AbgT putative transporter family; Region: ABG_transport; pfam03806 604162002311 Transposon insertion site of 22/35 mutant 604162002312 Transposon insertion site of 12/2 mutant 604162002313 Transposon insertion site of 2/40 mutant 604162002314 Transposon insertion site of 24/46 mutant 604162002315 Transposon insertion site of 23/46 mutant 604162002316 Transposon insertion site of 22/4 mutant 604162002317 Transposon insertion site of 76/35 mutant 604162002318 Transposon insertion site of 61/3 mutant 604162002319 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 604162002320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 604162002321 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 604162002322 Transposon insertion site of 0652/1 mutant 604162002323 Transposon insertion site of 50/31 mutant 604162002324 Transposon insertion site of 76/30 mutant 604162002325 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 604162002326 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 604162002327 HlyD family secretion protein; Region: HlyD_3; pfam13437 604162002328 Transposon insertion site of 90/1 mutant 604162002329 Transposon insertion site of 47/42 mutant 604162002330 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 604162002331 Transposon insertion site of 36/36 mutant 604162002332 Transposon insertion site of 55/14 mutant 604162002333 Transposon insertion site of 83/18 mutant 604162002334 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 604162002335 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 604162002336 L-lactate permease; Region: Lactate_perm; cl00701 604162002337 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 604162002338 Transposon insertion site of 33/31 mutant 604162002339 Transposon insertion site of 33/32 mutant 604162002340 Transposon insertion site of 85/35 mutant 604162002341 Transposon insertion site of 9/45 mutant 604162002342 Transposon insertion site of 90/33 mutant 604162002343 Transcriptional regulators [Transcription]; Region: FadR; COG2186 604162002344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 604162002345 DNA-binding site [nucleotide binding]; DNA binding site 604162002346 FCD domain; Region: FCD; pfam07729 604162002347 Transposon insertion site of 0658/1 mutant 604162002348 Evidence 7 : Gene remnant; Product type pf : putative factor 604162002349 Transposon insertion site of 36/31 mutant 604162002350 Transposon insertion site of 63/44 mutant 604162002351 Transposon insertion site of 33/12 mutant 604162002352 glutamate dehydrogenase; Provisional; Region: PRK09414 604162002353 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 604162002354 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 604162002355 NAD(P) binding site [chemical binding]; other site 604162002356 Transposon insertion site of 42/19 mutant 604162002357 Transposon insertion site of 81/21 mutant 604162002358 thymidylate synthase; Reviewed; Region: thyA; PRK01827 604162002359 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 604162002360 dimerization interface [polypeptide binding]; other site 604162002361 active site 604162002362 Evidence 7 : Gene remnant; Product type pe : putative enzyme 604162002363 Evidence 7 : Gene remnant; Product type pe : putative enzyme 604162002364 Transposon insertion site of 57/39 mutant 604162002365 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 604162002366 Na2 binding site [ion binding]; other site 604162002367 putative substrate binding site 1 [chemical binding]; other site 604162002368 Na binding site 1 [ion binding]; other site 604162002369 putative substrate binding site 2 [chemical binding]; other site 604162002370 Transposon insertion site of 10/12 mutant 604162002371 Transposon insertion site of 55/21 mutant 604162002372 Transposon insertion site of 28/47 mutant 604162002373 Transposon insertion site of 54/10 mutant 604162002374 Transposon insertion site of 33/20 mutant 604162002375 Transposon insertion site of 16/28 mutant 604162002376 Transposon insertion site of 27/11 mutant 604162002377 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 604162002378 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 604162002379 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 604162002380 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 604162002381 putative metal binding site; other site 604162002382 Transposon insertion site of 57/11 mutant 604162002383 Transposon insertion site of 23/19 mutant 604162002384 Transposon insertion site of 77/35 mutant 604162002385 Transposon insertion site of 81/14 mutant 604162002386 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 604162002387 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 604162002388 dimer interface [polypeptide binding]; other site 604162002389 active site 604162002390 Transposon insertion site of 17/8 mutant 604162002391 Transposon insertion site of 25/17 mutant 604162002392 Transposon insertion site of 42/42 mutant 604162002393 Transposon insertion site of 11/44 mutant 604162002394 Transposon insertion site of 43/18 mutant 604162002395 Transposon insertion site of 64/19 mutant 604162002396 Transposase domain (DUF772); Region: DUF772; pfam05598 604162002397 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162002398 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 604162002399 Evidence 7 : Gene remnant; Product type e : enzyme 604162002400 Transposon insertion site of 96/25 mutant 604162002401 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 604162002402 Transposon insertion site of 61/37 mutant 604162002403 Predicted membrane protein [Function unknown]; Region: COG4648 604162002404 Transposon insertion site of 48/34 mutant 604162002405 Transposon insertion site of 54/23 mutant 604162002406 Transposon insertion site of 63/27 mutant 604162002407 Transposon insertion site of 63/10 mutant 604162002408 Transposon insertion site of 66/27 mutant 604162002409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4899 604162002410 Transposon insertion site of 80/23 mutant 604162002411 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 604162002412 Transposon insertion site of 68/31 mutant 604162002413 Transposon insertion site of 67/11 mutant 604162002414 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 604162002415 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 604162002416 Transposon insertion site of 48/4 mutant 604162002417 Transposon insertion site of 37/39 mutant 604162002418 Transposon insertion site of 14/30 mutant 604162002419 Transposon insertion site of 67/43 mutant 604162002420 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 604162002421 Transposon insertion site of 68/14 mutant 604162002422 Transposon insertion site of 67/29 mutant 604162002423 Transposon insertion site of 64/39 mutant 604162002424 Transposon insertion site of 64/9 mutant 604162002425 Transposon insertion site of 13/14 mutant 604162002426 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 604162002427 dihydropteroate synthase; Region: DHPS; TIGR01496 604162002428 substrate binding pocket [chemical binding]; other site 604162002429 dimer interface [polypeptide binding]; other site 604162002430 inhibitor binding site; inhibition site 604162002431 Transposon insertion site of 56/12 mutant 604162002432 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 604162002433 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 604162002434 active site 604162002435 substrate binding site [chemical binding]; other site 604162002436 metal binding site [ion binding]; metal-binding site 604162002437 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 604162002438 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 604162002439 Transposon insertion site of 92/1 mutant 604162002440 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 604162002441 active site 604162002442 homodimer interface [polypeptide binding]; other site 604162002443 Transposon insertion site of 59/33 mutant 604162002444 Transposon insertion site of 88/34 mutant 604162002445 Transposon insertion site of 30/43 mutant 604162002446 Transposon insertion site of 48/18 mutant 604162002447 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 604162002448 active site 604162002449 Transposon insertion site of 18/28 mutant 604162002450 Transposon insertion site of 27/12 mutant 604162002451 Transposon insertion site of 58/10 mutant 604162002452 peptide chain release factor 1; Validated; Region: prfA; PRK00591 604162002453 This domain is found in peptide chain release factors; Region: PCRF; smart00937 604162002454 RF-1 domain; Region: RF-1; pfam00472 604162002455 Transposon insertion site of 62/16 mutant 604162002456 Transposon insertion site of 9/16 mutant 604162002457 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 604162002458 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 604162002459 putative ligand binding site [chemical binding]; other site 604162002460 putative NAD binding site [chemical binding]; other site 604162002461 catalytic site [active] 604162002462 Transposon insertion site of 73/17 mutant 604162002463 Transposon insertion site of 60/10 mutant 604162002464 seryl-tRNA synthetase; Provisional; Region: PRK05431 604162002465 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 604162002466 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 604162002467 dimer interface [polypeptide binding]; other site 604162002468 active site 604162002469 motif 1; other site 604162002470 motif 2; other site 604162002471 motif 3; other site 604162002472 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 604162002473 putative active site [active] 604162002474 Ap4A binding site [chemical binding]; other site 604162002475 nudix motif; other site 604162002476 putative metal binding site [ion binding]; other site 604162002477 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 604162002478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 604162002479 ATP binding site [chemical binding]; other site 604162002480 Mg2+ binding site [ion binding]; other site 604162002481 G-X-G motif; other site 604162002482 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 604162002483 anchoring element; other site 604162002484 dimer interface [polypeptide binding]; other site 604162002485 ATP binding site [chemical binding]; other site 604162002486 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 604162002487 active site 604162002488 metal binding site [ion binding]; metal-binding site 604162002489 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 604162002490 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 604162002491 Transposon insertion site of 94/19 mutant 604162002492 Transposon insertion site of 60/45 mutant 604162002493 Transposon insertion site of 23/31 mutant 604162002494 Transposon insertion site of 58/45 mutant 604162002495 Transposon insertion site of 24/19 mutant 604162002496 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 604162002497 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 604162002498 Tetramer interface [polypeptide binding]; other site 604162002499 active site 604162002500 FMN-binding site [chemical binding]; other site 604162002501 Transposon insertion site of 88/14 mutant 604162002502 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 604162002503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162002504 S-adenosylmethionine binding site [chemical binding]; other site 604162002505 Transposon insertion site of 16/21 mutant 604162002506 Transposon insertion site of 20/19 mutant 604162002507 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 604162002508 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 604162002509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162002510 homodimer interface [polypeptide binding]; other site 604162002511 catalytic residue [active] 604162002512 Transposon insertion site of 47/36 mutant 604162002513 Transposon insertion site of 36/29 mutant 604162002514 Transposon insertion site of 63/23 mutant 604162002515 Transposon insertion site of 45/7 mutant 604162002516 Transposon insertion site of 2/30 mutant 604162002517 Transposon insertion site of 24/39 mutant 604162002518 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 604162002519 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 604162002520 Transposon insertion site of 63/35 mutant 604162002521 Transposon insertion site of 88/11 mutant 604162002522 Transposon insertion site of 33/18 mutant 604162002523 Transposon insertion site of 29/11 mutant 604162002524 Transposon insertion site of 59/44 mutant 604162002525 Transposon insertion site of 95/10 mutant 604162002526 glycine dehydrogenase; Provisional; Region: PRK05367 604162002527 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 604162002528 tetramer interface [polypeptide binding]; other site 604162002529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162002530 catalytic residue [active] 604162002531 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 604162002532 tetramer interface [polypeptide binding]; other site 604162002533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162002534 catalytic residue [active] 604162002535 Transposon insertion site of 18/39 mutant 604162002536 Transposon insertion site of 21/35 mutant 604162002537 Transposon insertion site of 24/27 mutant 604162002538 Transposon insertion site of 47/4 mutant 604162002539 Transposon insertion site of 4/23 mutant 604162002540 Transposon insertion site of 51/2 mutant 604162002541 Transposon insertion site of 52/17 mutant 604162002542 Transposon insertion site of 87/5 mutant 604162002543 Transposon insertion site of 39/45 mutant 604162002544 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 604162002545 active site 604162002546 catalytic triad [active] 604162002547 oxyanion hole [active] 604162002548 switch loop; other site 604162002549 Transposon insertion site of 92/34 mutant 604162002550 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 604162002551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 604162002552 Protein of unknown function (DUF330); Region: DUF330; pfam03886 604162002553 Transposon insertion site of 87/27 mutant 604162002554 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 604162002555 mce related protein; Region: MCE; pfam02470 604162002556 mce related protein; Region: MCE; pfam02470 604162002557 Transposon insertion site of 42/2 mutant 604162002558 Transposon insertion site of 9/40 mutant 604162002559 Transposon insertion site of 87/32 mutant 604162002560 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 604162002561 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 604162002562 Paraquat-inducible protein A; Region: PqiA; pfam04403 604162002563 Paraquat-inducible protein A; Region: PqiA; pfam04403 604162002564 Transposon insertion site of 53/47 mutant 604162002565 Transposon insertion site of 75/9 mutant 604162002566 Transposon insertion site of 94/47 mutant 604162002567 Transposon insertion site of 18/47 mutant 604162002568 Transposon insertion site of 88/23 mutant 604162002569 Transposon insertion site of 53/23 mutant 604162002570 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 604162002571 heme binding pocket [chemical binding]; other site 604162002572 heme ligand [chemical binding]; other site 604162002573 Transposon insertion site of 15/12 mutant 604162002574 Transposon insertion site of 33/38 mutant 604162002575 Transposon insertion site of 80/38 mutant 604162002576 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 604162002577 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 604162002578 N-terminal plug; other site 604162002579 ligand-binding site [chemical binding]; other site 604162002580 Transposon insertion site of 25/40 mutant 604162002581 Transposon insertion site of 75/2 mutant 604162002582 Transposon insertion site of 11/19 mutant 604162002583 Transposon insertion site of 62/9 mutant 604162002584 Transposon insertion site of 86/9 mutant 604162002585 Transposon insertion site of 85/31 mutant 604162002586 Transposase domain (DUF772); Region: DUF772; pfam05598 604162002587 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162002588 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 604162002589 Transposon insertion site of 57/34 mutant 604162002590 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 604162002591 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 604162002592 putative active site [active] 604162002593 Transposon insertion site of 94/46 mutant 604162002594 Transposon insertion site of 14/6 mutant 604162002595 Transposon insertion site of 29/46 mutant 604162002596 Transposon insertion site of 29/10 and 59/48 mutants 604162002597 Transposon insertion site of 71/39 mutant 604162002598 Transposon insertion site of 12/29 mutant 604162002599 Transposon insertion site of 2/29 mutant 604162002600 Transposon insertion site of 25/45 mutant 604162002601 putative protease; Provisional; Region: PRK15452 604162002602 Peptidase family U32; Region: Peptidase_U32; pfam01136 604162002603 Transposon insertion site of 87/25 mutant 604162002604 Transposon insertion site of 92/46 mutant 604162002605 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 604162002606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 604162002607 active site 604162002608 motif I; other site 604162002609 motif II; other site 604162002610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 604162002611 Transposon insertion site of 58/4 mutant 604162002612 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 604162002613 active site 604162002614 Transposon insertion site of 49/6 mutant 604162002615 Transposon insertion site of 13/35 mutant 604162002616 Transposon insertion site of 34/1 mutant 604162002617 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 604162002618 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 604162002619 catalytic site [active] 604162002620 G-X2-G-X-G-K; other site 604162002621 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 604162002622 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 604162002623 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 604162002624 Zn2+ binding site [ion binding]; other site 604162002625 Mg2+ binding site [ion binding]; other site 604162002626 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 604162002627 synthetase active site [active] 604162002628 NTP binding site [chemical binding]; other site 604162002629 metal binding site [ion binding]; metal-binding site 604162002630 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 604162002631 ACT domain; Region: ACT_4; pfam13291 604162002632 Transposon insertion site of 66/6 mutant 604162002633 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 604162002634 Flavoprotein; Region: Flavoprotein; pfam02441 604162002635 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 604162002636 comEA protein; Region: comE; TIGR01259 604162002637 Helix-hairpin-helix motif; Region: HHH; pfam00633 604162002638 Evidence 7 : Gene remnant 604162002639 Transposon insertion site of 24/20 mutant 604162002640 Transposon insertion site of 28/14 mutant 604162002641 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 604162002642 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 604162002643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162002644 S-adenosylmethionine binding site [chemical binding]; other site 604162002645 Transposon insertion site of 62/44 mutant 604162002646 Transposon insertion site of 84/39 mutant 604162002647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 604162002648 Transposon insertion site of 32/6 mutant 604162002649 Transposon insertion site of 91/48 mutant 604162002650 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 604162002651 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 604162002652 Evidence 7 : Gene remnant; Product type e : enzyme 604162002653 Transposase domain (DUF772); Region: DUF772; pfam05598 604162002654 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162002655 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 604162002656 Evidence 7 : Gene remnant; Product type e : enzyme 604162002657 Transposon insertion site of 85/24 mutant 604162002658 Transposon insertion site of 9/29 mutant 604162002659 Transposon insertion site of 61/16 mutant 604162002660 Transposon insertion site of 51/28 mutant 604162002661 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 604162002662 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 604162002663 active site 604162002664 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 604162002665 substrate binding site [chemical binding]; other site 604162002666 catalytic residues [active] 604162002667 dimer interface [polypeptide binding]; other site 604162002668 Transposon insertion site of 80/17 mutant 604162002669 Transposon insertion site of 17/39 mutant 604162002670 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 604162002671 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 604162002672 putative DNA binding site [nucleotide binding]; other site 604162002673 putative Zn2+ binding site [ion binding]; other site 604162002674 AsnC family; Region: AsnC_trans_reg; pfam01037 604162002675 Transposon insertion site of 29/16 mutant 604162002676 Transposon insertion site of 52/4 mutant 604162002677 Transposon insertion site of 54/48 mutant 604162002678 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 604162002679 hypothetical protein; Validated; Region: PRK00110 604162002680 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 604162002681 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 604162002682 Transposon insertion site of 22/5 mutant 604162002683 Transposon insertion site of 2/9 mutant 604162002684 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 604162002685 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 604162002686 Transposon insertion site of 55/4 mutant 604162002687 Transposon insertion site of 8/12 mutant 604162002688 Transposon insertion site of 41/6 mutant 604162002689 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 604162002690 Transposon insertion site of 56/11 mutant 604162002691 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 604162002692 G1 box; other site 604162002693 GTP/Mg2+ binding site [chemical binding]; other site 604162002694 G2 box; other site 604162002695 Switch I region; other site 604162002696 G3 box; other site 604162002697 Switch II region; other site 604162002698 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 604162002699 Transposon insertion site of 42/13 mutant 604162002700 Transposon insertion site of 66/18 mutant 604162002701 Transposon insertion site of 44/2 mutant 604162002702 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 604162002703 translation initiation factor IF-2; Region: IF-2; TIGR00487 604162002704 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 604162002705 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 604162002706 G1 box; other site 604162002707 putative GEF interaction site [polypeptide binding]; other site 604162002708 GTP/Mg2+ binding site [chemical binding]; other site 604162002709 Switch I region; other site 604162002710 G2 box; other site 604162002711 G3 box; other site 604162002712 Switch II region; other site 604162002713 G4 box; other site 604162002714 G5 box; other site 604162002715 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 604162002716 Translation-initiation factor 2; Region: IF-2; pfam11987 604162002717 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 604162002718 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 604162002719 NusA N-terminal domain; Region: NusA_N; pfam08529 604162002720 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 604162002721 RNA binding site [nucleotide binding]; other site 604162002722 homodimer interface [polypeptide binding]; other site 604162002723 NusA-like KH domain; Region: KH_5; pfam13184 604162002724 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 604162002725 G-X-X-G motif; other site 604162002726 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 604162002727 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 604162002728 ribosome maturation protein RimP; Reviewed; Region: PRK00092 604162002729 Sm and related proteins; Region: Sm_like; cl00259 604162002730 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 604162002731 putative oligomer interface [polypeptide binding]; other site 604162002732 putative RNA binding site [nucleotide binding]; other site 604162002733 Transposon insertion site of 34/19 mutant 604162002734 Transposon insertion site of 56/19 mutant 604162002735 Transposon insertion site of 20/20 mutant 604162002736 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 604162002737 homodimer interface [polypeptide binding]; other site 604162002738 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 604162002739 substrate-cofactor binding pocket; other site 604162002740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162002741 catalytic residue [active] 604162002742 putative metal dependent hydrolase; Provisional; Region: PRK11598 604162002743 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 604162002744 Sulfatase; Region: Sulfatase; pfam00884 604162002745 Transposon insertion site of 2/27 mutant 604162002746 Transposon insertion site of 83/24 mutant 604162002747 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 604162002748 putative FMN binding site [chemical binding]; other site 604162002749 Transposon insertion site of 35/9 mutant 604162002750 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type m : membrane component 604162002751 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type m : membrane component 604162002752 Uncharacterized conserved protein [Function unknown]; Region: COG1262 604162002753 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 604162002754 Transposon insertion site of 71/42 mutant 604162002755 'Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 1383156, 1398981,9413436; Product type e : enzyme' 604162002756 'Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 1383156, 1398981,9413436; Product type e : enzyme' 604162002757 Transposon insertion site of 17/6 mutant 604162002758 Transposon insertion site of 2/38 mutant 604162002759 Transposon insertion site of 74/6 mutant 604162002760 Transposon insertion site of 18/32 mutant 604162002761 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002762 Transposon insertion site of 4/30 mutant 604162002763 Transposon insertion site of 13/20 mutant 604162002764 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002765 Transposon insertion site of 8/38 mutant 604162002766 Transposon insertion site of 48/15 and 67/32 mutants 604162002767 Transposon insertion site of 70/20 mutant 604162002768 Transposon insertion site of 30/10 mutant 604162002769 Transposon insertion site of 64/17 mutant 604162002770 Transposon insertion site of 39/47 mutant 604162002771 Transposon insertion site of 12/43 mutant 604162002772 Transposon insertion site of 10/7 mutant 604162002773 Transposon insertion site of 2/20 mutant 604162002774 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 604162002775 catalytic residues [active] 604162002776 dimer interface [polypeptide binding]; other site 604162002777 Transposon insertion site of 94/1 mutant 604162002778 Transposon insertion site of 1/13 mutant 604162002779 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 604162002780 dimer interface [polypeptide binding]; other site 604162002781 catalytic triad [active] 604162002782 Transposon insertion site of 91/8 mutant 604162002783 Transposon insertion site of 12/35 mutant 604162002784 HIT domain; Region: HIT; pfam01230 604162002785 HIT family signature motif; other site 604162002786 catalytic residue [active] 604162002787 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 604162002788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 604162002789 non-specific DNA binding site [nucleotide binding]; other site 604162002790 salt bridge; other site 604162002791 sequence-specific DNA binding site [nucleotide binding]; other site 604162002792 Transposon insertion site of 63/29 mutant 604162002793 Transposon insertion site of 87/2 mutant 604162002794 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 604162002795 RNA/DNA hybrid binding site [nucleotide binding]; other site 604162002796 active site 604162002797 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 604162002798 tellurite resistance protein TehB; Provisional; Region: PRK12335 604162002799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 604162002800 Transposon insertion site of 30/19 mutant 604162002801 Transposon insertion site of 93/12 mutant 604162002802 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 604162002803 dimer interface [polypeptide binding]; other site 604162002804 substrate binding site [chemical binding]; other site 604162002805 ATP binding site [chemical binding]; other site 604162002806 Transposon insertion site of 44/25 mutant 604162002807 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002808 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002809 Transposon insertion site of 62/25 mutant 604162002810 Transposon insertion site of 73/28 mutant 604162002811 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 604162002812 TrkA-N domain; Region: TrkA_N; pfam02254 604162002813 TrkA-C domain; Region: TrkA_C; pfam02080 604162002814 TrkA-N domain; Region: TrkA_N; pfam02254 604162002815 TrkA-C domain; Region: TrkA_C; pfam02080 604162002816 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 604162002817 Fumarase C-terminus; Region: Fumerase_C; pfam05683 604162002818 Transposon insertion site of 88/41 mutant 604162002819 Transposon insertion site of 4/41 mutant 604162002820 Transposon insertion site of 45/19 mutant 604162002821 Transposon insertion site of 53/3 mutant 604162002822 Transposon insertion site of 2/15 mutant 604162002823 Transposon insertion site of 90/37 mutant 604162002824 Transposon insertion site of 50/41 mutant 604162002825 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 604162002826 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 604162002827 substrate binding pocket [chemical binding]; other site 604162002828 membrane-bound complex binding site; other site 604162002829 hinge residues; other site 604162002830 Transposon insertion site of 38/27 mutant 604162002831 Transposon insertion site of 9/11 mutant 604162002832 Transposon insertion site of 38/20 mutant 604162002833 Transposon insertion site of 35/18 mutant 604162002834 Transposon insertion site of 71/3 mutant 604162002835 O-succinylhomoserine sulfhydrylase; Region: O_suc_HS_sulf; TIGR01325 604162002836 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 604162002837 homodimer interface [polypeptide binding]; other site 604162002838 substrate-cofactor binding pocket; other site 604162002839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162002840 catalytic residue [active] 604162002841 Transposon insertion site of 1/18 mutant 604162002842 Transposon insertion site of 10/45 mutant 604162002843 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 604162002844 Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445 604162002845 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 604162002846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 604162002847 active site 604162002848 phosphorylation site [posttranslational modification] 604162002849 intermolecular recognition site; other site 604162002850 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 604162002851 Transposon insertion site of 0773/1 mutant 604162002852 Predicted permeases [General function prediction only]; Region: COG0730 604162002853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 604162002854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 604162002855 ATP binding site [chemical binding]; other site 604162002856 Mg2+ binding site [ion binding]; other site 604162002857 G-X-G motif; other site 604162002858 Transposon insertion site of 33/9 mutant 604162002859 Transposon insertion site of 0774/1 mutant 604162002860 Transposon insertion site of 41/37 mutant 604162002861 Transposon insertion site of 49/2 mutant 604162002862 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 604162002863 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 604162002864 CAP-like domain; other site 604162002865 active site 604162002866 primary dimer interface [polypeptide binding]; other site 604162002867 Transposon insertion site of 64/1 mutant 604162002868 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 604162002869 catalytic core [active] 604162002870 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 604162002871 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 604162002872 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 604162002873 gating phenylalanine in ion channel; other site 604162002874 Transposon insertion site of 28/10 mutant 604162002875 Transposon insertion site of 60/16 mutant 604162002876 Transposon insertion site of 29/17 mutant 604162002877 Transposon insertion site of 38/29 mutant 604162002878 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 604162002879 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 604162002880 cofactor binding site; other site 604162002881 DNA binding site [nucleotide binding] 604162002882 substrate interaction site [chemical binding]; other site 604162002883 Transposon insertion site of 5/9 mutant 604162002884 Transposon insertion site of 44/11 mutant 604162002885 Transposon insertion site of 71/9 mutant 604162002886 Transposon insertion site of 85/17 mutant 604162002887 Transposon insertion site of 77/30 mutant 604162002888 Evidence 4 : Homologs of previously reported genes of unknown function 604162002889 Transposon insertion site of 45/25 mutant 604162002890 Transposon insertion site of 64/25 mutant 604162002891 Transposon insertion site of 7/43 mutant 604162002892 Transposon insertion site of 39/30 mutant 604162002893 Evidence 4 : Homologs of previously reported genes of unknown function 604162002894 Transposon insertion site of 27/17 mutant 604162002895 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 604162002896 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 604162002897 motif 1; other site 604162002898 active site 604162002899 motif 2; other site 604162002900 motif 3; other site 604162002901 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 604162002902 DHHA1 domain; Region: DHHA1; pfam02272 604162002903 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 604162002904 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 604162002905 Transposon insertion site of 29/6 mutant 604162002906 Transposon insertion site of 96/5 mutant 604162002907 Transposon insertion site of 58/16 mutant 604162002908 Transposon insertion site of 76/45 mutant 604162002909 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 604162002910 EamA-like transporter family; Region: EamA; pfam00892 604162002911 Transposon insertion site of 96/15 mutant 604162002912 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 604162002913 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 604162002914 Transposon insertion site of 64/28 mutant 604162002915 Transposon insertion site of 74/16 mutant 604162002916 Transposon insertion site of 9/18 mutant 604162002917 Transposon insertion site of 23/5 mutant 604162002918 Cupin; Region: Cupin_6; pfam12852 604162002919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 604162002920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 604162002921 Transposon insertion site of 15/30 mutant 604162002922 Transposon insertion site of 15/37 mutant 604162002923 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 604162002924 Transposon insertion site of 14/15 mutant 604162002925 Transposon insertion site of 94/44 mutant 604162002926 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 604162002927 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 604162002928 putative inner membrane peptidase; Provisional; Region: PRK11778 604162002929 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 604162002930 tandem repeat interface [polypeptide binding]; other site 604162002931 oligomer interface [polypeptide binding]; other site 604162002932 active site residues [active] 604162002933 Transposon insertion site of 35/1 mutant 604162002934 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 604162002935 Transposon insertion site of 66/26 mutant 604162002936 Transposon insertion site of 70/45 mutant 604162002937 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002938 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002939 Transposon insertion site of 73/25 mutant 604162002940 Transposon insertion site of 10/37 mutant 604162002941 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 604162002942 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 604162002943 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 604162002944 putative active site pocket [active] 604162002945 4-fold oligomerization interface [polypeptide binding]; other site 604162002946 metal binding residues [ion binding]; metal-binding site 604162002947 3-fold/trimer interface [polypeptide binding]; other site 604162002948 Transposon insertion site of 61/9 mutant 604162002949 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 604162002950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 604162002951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162002952 homodimer interface [polypeptide binding]; other site 604162002953 catalytic residue [active] 604162002954 Transposon insertion site of 19/39 mutant 604162002955 Transposon insertion site of 39/40 mutant 604162002956 Transposon insertion site of 83/45 mutant 604162002957 Transposon insertion site of 75/41 mutant 604162002958 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 604162002959 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 604162002960 NAD binding site [chemical binding]; other site 604162002961 dimerization interface [polypeptide binding]; other site 604162002962 product binding site; other site 604162002963 substrate binding site [chemical binding]; other site 604162002964 zinc binding site [ion binding]; other site 604162002965 catalytic residues [active] 604162002966 Transposon insertion site of 43/10 mutant 604162002967 Transposon insertion site of 70/48 mutant 604162002968 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 604162002969 GIY-YIG motif/motif A; other site 604162002970 putative active site [active] 604162002971 putative metal binding site [ion binding]; other site 604162002972 Transposon insertion site of 56/48 mutant 604162002973 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 604162002974 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 604162002975 Transposon insertion site of 16/3 mutant 604162002976 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 604162002977 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 604162002978 Cu(I) binding site [ion binding]; other site 604162002979 Transposon insertion site of 96/34 mutant 604162002980 Transposon insertion site of 41/28 mutant 604162002981 Transposon insertion site of 82/37 mutant 604162002982 Transposon insertion site of 88/30 mutant 604162002983 Transposase domain (DUF772); Region: DUF772; pfam05598 604162002984 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162002985 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 604162002986 Transposon insertion site of 21/12 mutant 604162002987 Transposon insertion site of 53/20 mutant 604162002988 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 604162002989 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 604162002990 active site 604162002991 Int/Topo IB signature motif; other site 604162002992 Transposon insertion site of 6/11 mutant 604162002993 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 604162002994 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 604162002995 oligomeric interface; other site 604162002996 putative active site [active] 604162002997 homodimer interface [polypeptide binding]; other site 604162002998 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162002999 Transposon insertion site of 19/2 mutant 604162003000 Transposon insertion site of 90/36 mutant 604162003001 Transposon insertion site of 10/25 mutant 604162003002 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162003003 Transposon insertion site of 30/42 mutant 604162003004 Transposon insertion site of 23/34 mutant 604162003005 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 604162003006 Predicted transcriptional regulator [Transcription]; Region: COG2944 604162003007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 604162003008 non-specific DNA binding site [nucleotide binding]; other site 604162003009 salt bridge; other site 604162003010 sequence-specific DNA binding site [nucleotide binding]; other site 604162003011 Transposon insertion site of 58/5 mutant 604162003012 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 604162003013 Toprim domain; Region: Toprim_3; pfam13362 604162003014 Domain of unknown function (DUF927); Region: DUF927; pfam06048 604162003015 Transposon insertion site of 68/27 mutant 604162003016 Transposon insertion site of 13/38 mutant 604162003017 Transposon insertion site of 35/8 mutant 604162003018 Transposon insertion site of 67/15 mutant 604162003019 Transposon insertion site of 45/15 mutant 604162003020 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 604162003021 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 604162003022 PYR/PP interface [polypeptide binding]; other site 604162003023 dimer interface [polypeptide binding]; other site 604162003024 TPP binding site [chemical binding]; other site 604162003025 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 604162003026 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 604162003027 TPP-binding site [chemical binding]; other site 604162003028 dimer interface [polypeptide binding]; other site 604162003029 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 604162003030 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 604162003031 putative valine binding site [chemical binding]; other site 604162003032 dimer interface [polypeptide binding]; other site 604162003033 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 604162003034 Transposon insertion site of 12/42 mutant 604162003035 Transposon insertion site of 52/29 mutant 604162003036 Transposon insertion site of 66/41 mutant 604162003037 Transposon insertion site of 58/2 mutant 604162003038 Uncharacterized conserved protein [Function unknown]; Region: COG1359 604162003039 Transposon insertion site of 26/36 mutant 604162003040 ketol-acid reductoisomerase; Provisional; Region: PRK05479 604162003041 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 604162003042 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 604162003043 Transposon insertion site of 83/37 mutant 604162003044 Transposon insertion site of 23/38 mutant 604162003045 ornithine carbamoyltransferase; Validated; Region: PRK02102 604162003046 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 604162003047 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 604162003048 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 604162003049 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 604162003050 substrate binding site [chemical binding]; other site 604162003051 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 604162003052 substrate binding site [chemical binding]; other site 604162003053 ligand binding site [chemical binding]; other site 604162003054 Transposon insertion site of 80/5 mutant 604162003055 Transposon insertion site of 81/31 mutant 604162003056 Predicted permeases [General function prediction only]; Region: COG0795 604162003057 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 604162003058 Predicted permeases [General function prediction only]; Region: COG0795 604162003059 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 604162003060 multifunctional aminopeptidase A; Provisional; Region: PRK00913 604162003061 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 604162003062 interface (dimer of trimers) [polypeptide binding]; other site 604162003063 Substrate-binding/catalytic site; other site 604162003064 Zn-binding sites [ion binding]; other site 604162003065 DNA polymerase III, chi subunit [DNA replication, recombination, and repair]; Region: HolC; COG2927 604162003066 Transposon insertion site of 74/12 mutant 604162003067 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 604162003068 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 604162003069 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 604162003070 Transposon insertion site of 15/10 mutant 604162003071 Transposon insertion site of 1/42 mutant 604162003072 Transposon insertion site of 63/4 mutant 604162003073 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 604162003074 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 604162003075 active site 604162003076 substrate binding site [chemical binding]; other site 604162003077 cosubstrate binding site; other site 604162003078 catalytic site [active] 604162003079 Transposon insertion site of 22/24 mutant 604162003080 Transposon insertion site of 2/2 mutant 604162003081 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 604162003082 Transposon insertion site of 14/35 mutant 604162003083 Transposon insertion site of 26/11 mutant 604162003084 OsmC-like protein; Region: OsmC; cl00767 604162003085 Transposon insertion site of 85/45 mutant 604162003086 Transposon insertion site of 87/46 mutant 604162003087 Transposon insertion site of 11/15 mutant 604162003088 Transposon insertion site of 60/3 mutant 604162003089 Transposon insertion site of 14/23 mutant 604162003090 Transposon insertion site of 68/19 mutant 604162003091 Transcriptional regulators [Transcription]; Region: GntR; COG1802 604162003092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 604162003093 DNA-binding site [nucleotide binding]; DNA binding site 604162003094 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 604162003095 Transposon insertion site of 90/30 mutant 604162003096 Predicted membrane protein [Function unknown]; Region: COG2431 604162003097 Transposon insertion site of 49/24 mutant 604162003098 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 604162003099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 604162003100 putative DNA binding site [nucleotide binding]; other site 604162003101 putative Zn2+ binding site [ion binding]; other site 604162003102 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 604162003103 Transposon insertion site of 63/24 mutant 604162003104 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 604162003105 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 604162003106 active site 604162003107 HIGH motif; other site 604162003108 nucleotide binding site [chemical binding]; other site 604162003109 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 604162003110 KMSKS motif; other site 604162003111 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 604162003112 glutathione synthetase; Provisional; Region: PRK05246 604162003113 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 604162003114 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 604162003115 Transposon insertion site of 51/11 mutant 604162003116 Transposon insertion site of 57/36 mutant 604162003117 Transposon insertion site of 30/4 mutant 604162003118 Transposon insertion site of 46/27 mutant 604162003119 Transposon insertion site of 45/14 mutant 604162003120 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 604162003121 Transposon insertion site of 33/3 mutant 604162003122 Transposon insertion site of 96/44 mutant 604162003123 Transposon insertion site of 50/13 mutant 604162003124 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 604162003125 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 604162003126 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 604162003127 Ligand Binding Site [chemical binding]; other site 604162003128 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 604162003129 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 604162003130 acyl-activating enzyme (AAE) consensus motif; other site 604162003131 putative AMP binding site [chemical binding]; other site 604162003132 putative active site [active] 604162003133 putative CoA binding site [chemical binding]; other site 604162003134 Transposon insertion site of 31/32 mutant 604162003135 Transposon insertion site of 25/47 mutant 604162003136 CTP synthetase; Validated; Region: pyrG; PRK05380 604162003137 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 604162003138 Catalytic site [active] 604162003139 active site 604162003140 UTP binding site [chemical binding]; other site 604162003141 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 604162003142 active site 604162003143 putative oxyanion hole; other site 604162003144 catalytic triad [active] 604162003145 Evidence 7 : Gene remnant; Product type e : enzyme 604162003146 Transposon insertion site of 36/22 mutant 604162003147 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 604162003148 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 604162003149 Transposon insertion site of 74/4 mutant 604162003150 Transposon insertion site of 23/20 mutant 604162003151 Transposon insertion site of 32/21 mutant 604162003152 Transposon insertion site of 66/24 mutant 604162003153 Transposon insertion site of 13/30 mutant 604162003154 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 604162003155 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 604162003156 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 604162003157 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 604162003158 Transposase domain (DUF772); Region: DUF772; pfam05598 604162003159 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162003160 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 604162003161 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 604162003162 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 604162003163 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 604162003164 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 604162003165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 604162003166 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 604162003167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 604162003168 DNA binding residues [nucleotide binding] 604162003169 DNA primase; Validated; Region: dnaG; PRK05667 604162003170 CHC2 zinc finger; Region: zf-CHC2; pfam01807 604162003171 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 604162003172 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 604162003173 active site 604162003174 metal binding site [ion binding]; metal-binding site 604162003175 interdomain interaction site; other site 604162003176 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 604162003177 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 604162003178 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 604162003179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 604162003180 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 604162003181 SEC-C motif; Region: SEC-C; pfam02810 604162003182 Protein of unknown function (DUF721); Region: DUF721; pfam05258 604162003183 Transposon insertion site of 78/4 mutant 604162003184 Azurin [Energy production and conversion]; Region: COG3241 604162003185 Hemerythrin-like domain; Region: Hr-like; cd12108 604162003186 Fe binding site [ion binding]; other site 604162003187 Transposon insertion site of 51/10 mutant 604162003188 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 604162003189 Transposon insertion site of 94/27 mutant 604162003190 Transposon insertion site of 57/37 mutant 604162003191 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 604162003192 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 604162003193 metal binding site [ion binding]; metal-binding site 604162003194 dimer interface [polypeptide binding]; other site 604162003195 Transposon insertion site of 70/4 mutant 604162003196 Transposon insertion site of 34/2 mutant 604162003197 Evidence 7 : Gene remnant; Product type pr : putative regulator 604162003198 Evidence 7 : Gene remnant; Product type pr : putative regulator 604162003199 Evidence 7 : Gene remnant 604162003200 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 604162003201 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 604162003202 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 604162003203 DNA binding site [nucleotide binding] 604162003204 active site 604162003205 Transposon insertion site of 84/8 mutant 604162003206 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 604162003207 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 604162003208 putative active site [active] 604162003209 Transposon insertion site of 70/7 mutant 604162003210 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 604162003211 SmpB-tmRNA interface; other site 604162003212 Transposon insertion site of 58/42 mutant 604162003213 Transposon insertion site of 45/24 mutant 604162003214 Transposon insertion site of 52/25 mutant 604162003215 Transposon insertion site of 93/15 mutant 604162003216 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10972828; Product type pf : putative factor 604162003217 Transposon insertion site of 81/26 mutant 604162003218 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10972828; Product type pf : putative factor 604162003219 Transposon insertion site of 11/29 mutant 604162003220 Transposon insertion site of 59/13 mutant 604162003221 Transposon insertion site of 68/13 mutant 604162003222 Transposon insertion site of 51/41 mutant 604162003223 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 604162003224 FAD binding domain; Region: FAD_binding_4; pfam01565 604162003225 Transposon insertion site of 96/24 mutant 604162003226 Transposon insertion site of 76/47 mutant 604162003227 Transposon insertion site of 20/14 mutant 604162003228 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 604162003229 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 604162003230 Transposon insertion site of 61/2 mutant 604162003231 Transposon insertion site of 3/47 mutant 604162003232 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 604162003233 active site lid residues [active] 604162003234 substrate binding pocket [chemical binding]; other site 604162003235 catalytic residues [active] 604162003236 substrate-Mg2+ binding site; other site 604162003237 aspartate-rich region 1; other site 604162003238 aspartate-rich region 2; other site 604162003239 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 604162003240 Transposon insertion site of 8/26 mutant 604162003241 Transposon insertion site of 52/37 mutant 604162003242 Transposon insertion site of 59/23 mutant 604162003243 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 604162003244 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 604162003245 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 604162003246 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 604162003247 DsbD alpha interface [polypeptide binding]; other site 604162003248 catalytic residues [active] 604162003249 Transposon insertion site of 69/39 mutant 604162003250 Transposon insertion site of 29/14 mutant 604162003251 Transposon insertion site of 38/11 mutant 604162003252 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 604162003253 propionate/acetate kinase; Provisional; Region: PRK12379 604162003254 Transposon insertion site of 85/42 mutant 604162003255 Transposon insertion site of 29/9 mutant 604162003256 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 604162003257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 604162003258 Transposon insertion site of 37/41 mutant 604162003259 Transposon insertion site of 50/30 mutant 604162003260 Transposon insertion site of 11/20 mutant 604162003261 Transposon insertion site of 77/6 mutant 604162003262 Transposon insertion site of 62/4 mutant 604162003263 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 604162003264 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 604162003265 active site 604162003266 catalytic site [active] 604162003267 substrate binding site [chemical binding]; other site 604162003268 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 604162003269 substrate binding site; other site 604162003270 dimer interface; other site 604162003271 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 604162003272 homotrimer interaction site [polypeptide binding]; other site 604162003273 zinc binding site [ion binding]; other site 604162003274 CDP-binding sites; other site 604162003275 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 604162003276 tetramer (dimer of dimers) interface [polypeptide binding]; other site 604162003277 active site 604162003278 dimer interface [polypeptide binding]; other site 604162003279 Staphylococcal nuclease homologues; Region: SNc; smart00318 604162003280 Catalytic site; other site 604162003281 Staphylococcal nuclease homologue; Region: SNase; pfam00565 604162003282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 604162003283 dimer interface [polypeptide binding]; other site 604162003284 conserved gate region; other site 604162003285 putative PBP binding loops; other site 604162003286 ABC-ATPase subunit interface; other site 604162003287 Transposon insertion site of 56/4 mutant 604162003288 Transposon insertion site of 24/40 mutant 604162003289 Transposon insertion site of 8/9 mutant 604162003290 Transposon insertion site of 3/28 mutant 604162003291 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 604162003292 Sulfatase; Region: Sulfatase; cl17466 604162003293 Transposon insertion site of 49/33 mutant 604162003294 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 604162003295 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 604162003296 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 604162003297 active site 604162003298 HIGH motif; other site 604162003299 KMSK motif region; other site 604162003300 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 604162003301 tRNA binding surface [nucleotide binding]; other site 604162003302 anticodon binding site; other site 604162003303 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 604162003304 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 604162003305 active site 604162003306 Transposon insertion site of 23/27 mutant 604162003307 Transposon insertion site of 45/35 mutant 604162003308 Transposon insertion site of 84/38 mutant 604162003309 Transposon insertion site of 91/46 mutant 604162003310 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 604162003311 Transposon insertion site of 73/1 mutant 604162003312 Transposon insertion site of 56/32 mutant 604162003313 Transposon insertion site of 4/3 mutant 604162003314 Transposon insertion site of 76/31 mutant 604162003315 Transposon insertion site of 75/23 mutant 604162003316 Transposon insertion site of 40/13 mutant 604162003317 Transposon insertion site of 49/13 mutant 604162003318 Transposon insertion site of 74/13 mutant 604162003319 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 604162003320 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 604162003321 putative ATP binding site [chemical binding]; other site 604162003322 putative substrate interface [chemical binding]; other site 604162003323 Transposon insertion site of 65/32 mutant 604162003324 Transposon insertion site of 18/1 mutant 604162003325 Transposon insertion site of 20/8 mutant 604162003326 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 604162003327 Ligand Binding Site [chemical binding]; other site 604162003328 ribonuclease PH; Reviewed; Region: rph; PRK00173 604162003329 Ribonuclease PH; Region: RNase_PH_bact; cd11362 604162003330 hexamer interface [polypeptide binding]; other site 604162003331 active site 604162003332 Transposon insertion site of 6/34 mutant 604162003333 aspartate kinase; Reviewed; Region: PRK06635 604162003334 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 604162003335 putative nucleotide binding site [chemical binding]; other site 604162003336 putative catalytic residues [active] 604162003337 putative Mg ion binding site [ion binding]; other site 604162003338 putative aspartate binding site [chemical binding]; other site 604162003339 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 604162003340 putative allosteric regulatory site; other site 604162003341 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 604162003342 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 604162003343 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 604162003344 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 604162003345 Transposon insertion site of 75/6 mutant 604162003346 Transposon insertion site of 27/43 mutant 604162003347 Transposon insertion site of 84/19 mutant 604162003348 Uncharacterized small protein [Function unknown]; Region: COG2879 604162003349 Transposon insertion site of 42/32 mutant 604162003350 carbon starvation protein A; Provisional; Region: PRK15015 604162003351 Carbon starvation protein CstA; Region: CstA; pfam02554 604162003352 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 604162003353 Transposon insertion site of 38/5 mutant 604162003354 Transposon insertion site of 79/2 mutant 604162003355 Predicted periplasmic protein [General function prediction only]; Region: COG3895 604162003356 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 604162003357 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 604162003358 Transposon insertion site of 20/48 mutant 604162003359 Transposon insertion site of 65/33 mutant 604162003360 Transposon insertion site of 46/34 mutant 604162003361 succinic semialdehyde dehydrogenase; Region: PLN02278 604162003362 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 604162003363 tetramerization interface [polypeptide binding]; other site 604162003364 NAD(P) binding site [chemical binding]; other site 604162003365 catalytic residues [active] 604162003366 Transposon insertion site of 1695(4) mutant 604162003367 Transposon insertion site of 1695(8) mutant 604162003368 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 604162003369 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 604162003370 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 604162003371 Transporter associated domain; Region: CorC_HlyC; smart01091 604162003372 Transposon insertion site of 17/18 mutant 604162003373 Transposon insertion site of 56/31 mutant 604162003374 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 604162003375 Transposon insertion site of 32/42 mutant 604162003376 Transposon insertion site of 27/37 mutant 604162003377 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 604162003378 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 604162003379 Peptidase family M23; Region: Peptidase_M23; pfam01551 604162003380 Transposon insertion site of 70/17 mutant 604162003381 Transposon insertion site of 13/8 mutant 604162003382 Transposon insertion site of 85/47 mutant 604162003383 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 604162003384 Transposon insertion site of 88/35 mutant 604162003385 Transposon insertion site of 25/11 mutant 604162003386 Transposon insertion site of 69/46 mutant 604162003387 Transposon insertion site of 65/37 mutant 604162003388 Transposon insertion site of 11/4 mutant 604162003389 recombination regulator RecX; Reviewed; Region: recX; PRK00117 604162003390 Transposon insertion site of 78/30 mutant 604162003391 Transposon insertion site of 91/9 mutant 604162003392 phosphoglycolate phosphatase; Provisional; Region: PRK13222 604162003393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 604162003394 motif II; other site 604162003395 Transposon insertion site of 22/10 mutant 604162003396 Transposon insertion site of 22/44 mutant 604162003397 Transposon insertion site of 87/11 mutant 604162003398 Transposon insertion site of 35/31 mutant 604162003399 Transposon insertion site of 5/11 mutant 604162003400 Transposon insertion site of 69/18 mutant 604162003401 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 604162003402 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 604162003403 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 604162003404 NAD(P) binding site [chemical binding]; other site 604162003405 Transposon insertion site of 15/36 mutant 604162003406 Transposon insertion site of 64/36 mutant 604162003407 Transposon insertion site of 22/20 mutant 604162003408 Transposon insertion site of 31/48 mutant 604162003409 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 604162003410 Transposon insertion site of 84/4 mutant 604162003411 Transposon insertion site of 21/7 mutant 604162003412 Transposon insertion site of 51/36 mutant 604162003413 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 604162003414 active site 1 [active] 604162003415 dimer interface [polypeptide binding]; other site 604162003416 hexamer interface [polypeptide binding]; other site 604162003417 active site 2 [active] 604162003418 Transposon insertion site of 50/28 mutant 604162003419 aminotransferase AlaT; Validated; Region: PRK09265 604162003420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 604162003421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162003422 homodimer interface [polypeptide binding]; other site 604162003423 catalytic residue [active] 604162003424 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 604162003425 Clp amino terminal domain; Region: Clp_N; pfam02861 604162003426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162003427 Walker A motif; other site 604162003428 ATP binding site [chemical binding]; other site 604162003429 Walker B motif; other site 604162003430 arginine finger; other site 604162003431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162003432 Walker A motif; other site 604162003433 ATP binding site [chemical binding]; other site 604162003434 Walker B motif; other site 604162003435 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 604162003436 Transposon insertion site of 62/34 mutant 604162003437 Transposon insertion site of 78/3 mutant 604162003438 Transposon insertion site of 52/46 mutant 604162003439 Transposon insertion site of 8/48 mutant 604162003440 Transposon insertion site of 11/23 mutant 604162003441 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 604162003442 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 604162003443 active site 604162003444 HIGH motif; other site 604162003445 dimer interface [polypeptide binding]; other site 604162003446 KMSKS motif; other site 604162003447 Transposon insertion site of 75/45 mutant 604162003448 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 604162003449 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 604162003450 Transposon insertion site of 4/44 mutant 604162003451 Transposon insertion site of 45/46 mutant 604162003452 Protein of unknown function (DUF560); Region: DUF560; pfam04575 604162003453 Transposon insertion site of 56/27 mutant 604162003454 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type m : membrane component 604162003455 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type m : membrane component 604162003456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 604162003457 Transposon insertion site of 36/20 mutant 604162003458 Evidence 7 : Gene remnant; Product type e : enzyme 604162003459 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 604162003460 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 604162003461 N-acetyl-D-glucosamine binding site [chemical binding]; other site 604162003462 catalytic residue [active] 604162003463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 604162003464 Major Facilitator Superfamily; Region: MFS_1; pfam07690 604162003465 putative substrate translocation pore; other site 604162003466 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 604162003467 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 604162003468 dimer interface [polypeptide binding]; other site 604162003469 ssDNA binding site [nucleotide binding]; other site 604162003470 tetramer (dimer of dimers) interface [polypeptide binding]; other site 604162003471 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 604162003472 EamA-like transporter family; Region: EamA; pfam00892 604162003473 Transposon insertion site of 26/33 mutant 604162003474 fumarate hydratase; Reviewed; Region: fumC; PRK00485 604162003475 Class II fumarases; Region: Fumarase_classII; cd01362 604162003476 active site 604162003477 tetramer interface [polypeptide binding]; other site 604162003478 transketolase; Reviewed; Region: PRK12753 604162003479 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 604162003480 TPP-binding site [chemical binding]; other site 604162003481 dimer interface [polypeptide binding]; other site 604162003482 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 604162003483 PYR/PP interface [polypeptide binding]; other site 604162003484 dimer interface [polypeptide binding]; other site 604162003485 TPP binding site [chemical binding]; other site 604162003486 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 604162003487 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 604162003488 4Fe-4S binding domain; Region: Fer4_5; pfam12801 604162003489 4Fe-4S binding domain; Region: Fer4_3; pfam12798 604162003490 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 604162003491 Transposon insertion site of 32/7 mutant 604162003492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 604162003493 FixH; Region: FixH; pfam05751 604162003494 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 604162003495 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 604162003496 FMN binding site [chemical binding]; other site 604162003497 substrate binding site [chemical binding]; other site 604162003498 putative catalytic residue [active] 604162003499 Transposon insertion site of 60/6 mutant 604162003500 Transposon insertion site of 23/32 mutant 604162003501 Transposon insertion site of 45/12 mutant 604162003502 Transposon insertion site of 66/48 mutant 604162003503 Transposon insertion site of 63/48 mutant 604162003504 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 604162003505 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 604162003506 active site 604162003507 catalytic site [active] 604162003508 substrate binding site [chemical binding]; other site 604162003509 Transposon insertion site of 9/27 mutant 604162003510 Transposon insertion site of 25/39 mutant 604162003511 Transposon insertion site of 3/48 mutant 604162003512 Transposon insertion site of 34/45 mutant 604162003513 Transposon insertion site of 65/35 mutant 604162003514 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 604162003515 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 604162003516 FAD binding pocket [chemical binding]; other site 604162003517 FAD binding motif [chemical binding]; other site 604162003518 phosphate binding motif [ion binding]; other site 604162003519 beta-alpha-beta structure motif; other site 604162003520 NAD binding pocket [chemical binding]; other site 604162003521 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162003522 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162003523 Evidence 7 : Gene remnant 604162003524 Transposon insertion site of 13/36 mutant 604162003525 Transposon insertion site of 77/7 mutant 604162003526 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 604162003527 active site 604162003528 DNA polymerase IV; Validated; Region: PRK02406 604162003529 DNA binding site [nucleotide binding] 604162003530 Transposon insertion site of 69/9 mutant 604162003531 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 604162003532 Family description; Region: UvrD_C_2; pfam13538 604162003533 Transposon insertion site of 71/37 mutant 604162003534 Transposon insertion site of 20/47 mutant 604162003535 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 604162003536 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 604162003537 active site 604162003538 catalytic residue [active] 604162003539 dimer interface [polypeptide binding]; other site 604162003540 Transposon insertion site of 42/5 mutant 604162003541 recombinase A; Provisional; Region: recA; PRK09354 604162003542 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 604162003543 hexamer interface [polypeptide binding]; other site 604162003544 Walker A motif; other site 604162003545 ATP binding site [chemical binding]; other site 604162003546 Walker B motif; other site 604162003547 Transposon insertion site of 38/33 mutant 604162003548 Transposon insertion site of 75/5 mutant 604162003549 Transposon insertion site of 64/48 mutant 604162003550 hypothetical protein; Validated; Region: PRK00153 604162003551 Transposon insertion site of 87/48 mutant 604162003552 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08691 604162003553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162003554 Walker A motif; other site 604162003555 ATP binding site [chemical binding]; other site 604162003556 Walker B motif; other site 604162003557 arginine finger; other site 604162003558 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 604162003559 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 604162003560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 604162003561 ATP binding site [chemical binding]; other site 604162003562 Mg2+ binding site [ion binding]; other site 604162003563 G-X-G motif; other site 604162003564 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 604162003565 ATP binding site [chemical binding]; other site 604162003566 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 604162003567 Transposon insertion site of 21/5 mutant 604162003568 Transposon insertion site of 57/18 mutant 604162003569 Transposon insertion site of 1/8 mutant 604162003570 Transposon insertion site of 3/27 mutant 604162003571 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 604162003572 Transposon insertion site of 59/36 mutant 604162003573 Transposon insertion site of 39/10 mutant 604162003574 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 604162003575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162003576 S-adenosylmethionine binding site [chemical binding]; other site 604162003577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 604162003578 Tetratricopeptide repeat; Region: TPR_6; pfam13174 604162003579 Transposon insertion site of 54/17 mutant 604162003580 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 604162003581 Transposon insertion site of 60/29 mutant 604162003582 Transposon insertion site of 43/35 mutant 604162003583 Transposon insertion site of 41/39 mutant 604162003584 Transposon insertion site of 18/29 mutant 604162003585 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 604162003586 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 604162003587 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 604162003588 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 604162003589 Uncharacterized conserved protein [Function unknown]; Region: COG1556 604162003590 Transposon insertion site of 18/22 mutant 604162003591 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 604162003592 Cysteine-rich domain; Region: CCG; pfam02754 604162003593 Cysteine-rich domain; Region: CCG; pfam02754 604162003594 Transposon insertion site of 70/24 mutant 604162003595 Transposon insertion site of 81/1 mutant 604162003596 Transposon insertion site of 33/28 mutant 604162003597 Transposon insertion site of 10/3 mutant 604162003598 putative transporter; Provisional; Region: PRK10504 604162003599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 604162003600 putative substrate translocation pore; other site 604162003601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 604162003602 Transposon insertion site of 67/48 mutant 604162003603 Transposon insertion site of 16/48 mutant 604162003604 Transposon insertion site of 27/35 mutant 604162003605 Transposon insertion site of 40/22 mutant 604162003606 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 604162003607 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 604162003608 putative active site [active] 604162003609 catalytic site [active] 604162003610 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 604162003611 putative active site [active] 604162003612 catalytic site [active] 604162003613 Transposon insertion site of 60/41 mutant 604162003614 Transposon insertion site of 8/36 mutant 604162003615 Transposon insertion site of 14/4 mutant 604162003616 Transposon insertion site of 95/48 mutant 604162003617 Transposon insertion site of 96/48 mutant 604162003618 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 604162003619 NlpC/P60 family; Region: NLPC_P60; pfam00877 604162003620 Transposon insertion site of 86/10 mutant 604162003621 Transposon insertion site of 92/13 mutant 604162003622 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 604162003623 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 604162003624 hinge; other site 604162003625 active site 604162003626 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 604162003627 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 604162003628 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 604162003629 Transposon insertion site of 70/25 mutant 604162003630 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 604162003631 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 604162003632 eyelet of channel; other site 604162003633 trimer interface [polypeptide binding]; other site 604162003634 Transposon insertion site of 6/4 mutant 604162003635 Transposon insertion site of 55/1 mutant 604162003636 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 604162003637 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 604162003638 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 604162003639 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 604162003640 active site 604162003641 Transposon insertion site of 32/10 mutant 604162003642 Transposon insertion site of 87/14 mutant 604162003643 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 604162003644 Transposon insertion site of 61/48 mutant 604162003645 Transposon insertion site of 78/13 mutant 604162003646 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 604162003647 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 604162003648 dimer interface [polypeptide binding]; other site 604162003649 putative anticodon binding site; other site 604162003650 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 604162003651 motif 1; other site 604162003652 active site 604162003653 motif 2; other site 604162003654 motif 3; other site 604162003655 Transposase domain (DUF772); Region: DUF772; pfam05598 604162003656 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162003657 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 604162003658 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162003659 Transposon insertion site of 20/43 mutant 604162003660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 604162003661 Transposon insertion site of 25/18 mutant 604162003662 Transposon insertion site of 32/16 mutant 604162003663 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 604162003664 Helix-turn-helix domain; Region: HTH_38; pfam13936 604162003665 Homeodomain-like domain; Region: HTH_32; pfam13565 604162003666 Integrase core domain; Region: rve; pfam00665 604162003667 Transposon insertion site of 6/24 mutant 604162003668 Transposon insertion site of 67/18 mutant 604162003669 Transposase domain (DUF772); Region: DUF772; pfam05598 604162003670 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162003671 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 604162003672 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 604162003673 Transposon insertion site of 25/35 mutant 604162003674 potential frameshift: common BLAST hit: gi|313667867|ref|YP_004048151.1| FAD-binding protein 604162003675 Transposon insertion site of 9/39 mutant 604162003676 Transposon insertion site of 52/39 mutant 604162003677 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 604162003678 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 604162003679 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 604162003680 ATP binding site [chemical binding]; other site 604162003681 Mg++ binding site [ion binding]; other site 604162003682 motif III; other site 604162003683 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 604162003684 nucleotide binding region [chemical binding]; other site 604162003685 ATP-binding site [chemical binding]; other site 604162003686 Transposon insertion site of 48/12 mutant 604162003687 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 604162003688 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 604162003689 FMN binding site [chemical binding]; other site 604162003690 active site 604162003691 catalytic residues [active] 604162003692 substrate binding site [chemical binding]; other site 604162003693 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 604162003694 DNA-binding protein Fis; Provisional; Region: PRK01905 604162003695 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 604162003696 active site 604162003697 putative DNA-binding cleft [nucleotide binding]; other site 604162003698 dimer interface [polypeptide binding]; other site 604162003699 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 604162003700 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 604162003701 putative acyl-acceptor binding pocket; other site 604162003702 Transposon insertion site of 6/26 mutant 604162003703 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 604162003704 active site 604162003705 catalytic site [active] 604162003706 substrate binding site [chemical binding]; other site 604162003707 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 604162003708 Transposon insertion site of 53/17 mutant 604162003709 aminopeptidase N; Provisional; Region: pepN; PRK14015 604162003710 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 604162003711 active site 604162003712 Zn binding site [ion binding]; other site 604162003713 Transposon insertion site of 81/19 mutant 604162003714 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 604162003715 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 604162003716 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 604162003717 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 604162003718 Transposon insertion site of 45/37 mutant 604162003719 Transposon insertion site of 6/37 mutant 604162003720 Transposon insertion site of 46/12 mutant 604162003721 Transposon insertion site of 19/7 mutant 604162003722 Transposon insertion site of 13/41 mutant 604162003723 Transposon insertion site of 16/35 mutant 604162003724 Transposon insertion site of 55/3 mutant 604162003725 Transposon insertion site of 39/16 mutant 604162003726 Transposon insertion site of 9/1 mutant 604162003727 Transposon insertion site of 27/41 mutant 604162003728 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor' 604162003729 Transposon insertion site of 88/48 mutant 604162003730 Transposon insertion site of 84/27 mutant 604162003731 Evidence 7 : Gene remnant; Product type e : enzyme 604162003732 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 604162003733 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 604162003734 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 604162003735 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 604162003736 Walker A/P-loop; other site 604162003737 ATP binding site [chemical binding]; other site 604162003738 Q-loop/lid; other site 604162003739 ABC transporter signature motif; other site 604162003740 Walker B; other site 604162003741 D-loop; other site 604162003742 H-loop/switch region; other site 604162003743 Transposon insertion site of 73/38 mutant 604162003744 Transposon insertion site of 79/7 mutant 604162003745 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162003746 Transposon insertion site of 22/37 mutant 604162003747 Transposon insertion site of 52/40 mutant 604162003748 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162003749 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 604162003750 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 604162003751 E-class dimer interface [polypeptide binding]; other site 604162003752 P-class dimer interface [polypeptide binding]; other site 604162003753 active site 604162003754 Cu2+ binding site [ion binding]; other site 604162003755 Zn2+ binding site [ion binding]; other site 604162003756 Transposon insertion site of 58/34 mutant 604162003757 Transposon insertion site of 1/47 mutant 604162003758 Transposon insertion site of 69/30 mutant 604162003759 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 604162003760 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 604162003761 minor groove reading motif; other site 604162003762 helix-hairpin-helix signature motif; other site 604162003763 substrate binding pocket [chemical binding]; other site 604162003764 active site 604162003765 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 604162003766 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 604162003767 DNA binding and oxoG recognition site [nucleotide binding] 604162003768 Transposon insertion site of 30/37 mutant 604162003769 Transposon insertion site of 57/17 mutant 604162003770 Transposon insertion site of 24/7 mutant 604162003771 Transposon insertion site of 31/7 mutant 604162003772 Transposon insertion site of 14/37 mutant 604162003773 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162003774 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162003775 Transposon insertion site of 79/14 mutant 604162003776 Transposon insertion site of 81/23 mutant 604162003777 Transposon insertion site of 76/43 mutant 604162003778 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 604162003779 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 604162003780 active site 604162003781 intersubunit interface [polypeptide binding]; other site 604162003782 catalytic residue [active] 604162003783 phosphogluconate dehydratase; Validated; Region: PRK09054 604162003784 6-phosphogluconate dehydratase; Region: edd; TIGR01196 604162003785 Transposon insertion site of 33/48 mutant 604162003786 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 604162003787 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 604162003788 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 604162003789 Transposon insertion site of 94/12 mutant 604162003790 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 604162003791 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 604162003792 putative active site [active] 604162003793 glucokinase; Provisional; Region: glk; PRK00292 604162003794 glucokinase, proteobacterial type; Region: glk; TIGR00749 604162003795 Transposon insertion site of 51/26 mutant 604162003796 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 604162003797 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 604162003798 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 604162003799 putative active site [active] 604162003800 Transposon insertion site of 1005/1 mutant 604162003801 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 604162003802 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 604162003803 active site 604162003804 dimer interface [polypeptide binding]; other site 604162003805 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 604162003806 dimer interface [polypeptide binding]; other site 604162003807 active site 604162003808 Transposon insertion site of 29/40 mutant 604162003809 Transposon insertion site of 48/41 mutant 604162003810 Transposon insertion site of 96/13 mutant 604162003811 Evidence 7 : Gene remnant; Product type e : enzyme 604162003812 Evidence 7 : Gene remnant; Product type e : enzyme 604162003813 Evidence 7 : Gene remnant; Product type e : enzyme 604162003814 Transposon insertion site of 49/31 mutant 604162003815 DNA gyrase subunit A; Validated; Region: PRK05560 604162003816 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 604162003817 CAP-like domain; other site 604162003818 active site 604162003819 primary dimer interface [polypeptide binding]; other site 604162003820 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 604162003821 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 604162003822 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 604162003823 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 604162003824 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 604162003825 co-chaperone HscB; Provisional; Region: hscB; PRK03578 604162003826 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 604162003827 HSP70 interaction site [polypeptide binding]; other site 604162003828 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 604162003829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 604162003830 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 604162003831 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 604162003832 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 604162003833 trimerization site [polypeptide binding]; other site 604162003834 active site 604162003835 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 604162003836 cysteine desulfurase; Provisional; Region: PRK14012 604162003837 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 604162003838 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 604162003839 catalytic residue [active] 604162003840 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 604162003841 Rrf2 family protein; Region: rrf2_super; TIGR00738 604162003842 Transposon insertion site of 1019/1 mutant 604162003843 Transposon insertion site of 83/15 mutant 604162003844 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 604162003845 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 604162003846 phosphate binding site [ion binding]; other site 604162003847 Transposon insertion site of 84/42 mutant 604162003848 Transposon insertion site of 20/1 mutant 604162003849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 604162003850 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162003851 Transposon insertion site of 64/20 mutant 604162003852 Transposon insertion site of 57/23 mutant 604162003853 Transposon insertion site of 48/47 mutant 604162003854 Transposon insertion site of 56/2 mutant 604162003855 Transposon insertion site of 15/5 mutant 604162003856 Transposon insertion site of 45/18 mutant 604162003857 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162003858 Transposon insertion site of 16/4 mutant 604162003859 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 604162003860 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 604162003861 RNA binding site [nucleotide binding]; other site 604162003862 active site 604162003863 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 604162003864 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 604162003865 Transposon insertion site of 63/34 mutant 604162003866 Transposon insertion site of 71/22 mutant 604162003867 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 604162003868 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 604162003869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162003870 Walker A motif; other site 604162003871 ATP binding site [chemical binding]; other site 604162003872 Walker B motif; other site 604162003873 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 604162003874 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 604162003875 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 604162003876 inhibitor-cofactor binding pocket; inhibition site 604162003877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162003878 catalytic residue [active] 604162003879 Transposon insertion site of 17/43 mutant 604162003880 Transposon insertion site of 9/48 mutant 604162003881 Transposon insertion site of 42/43 mutant 604162003882 Evidence 5 : No homology to any previously reported sequences 604162003883 Transposon insertion site of 75/14 mutant 604162003884 Evidence 5 : No homology to any previously reported sequences 604162003885 Transposon insertion site of 24/1 mutant 604162003886 Transposon insertion site of 96/10 mutant 604162003887 Transposon insertion site of 83/5 mutant 604162003888 helicase 45; Provisional; Region: PTZ00424 604162003889 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 604162003890 ATP binding site [chemical binding]; other site 604162003891 Mg++ binding site [ion binding]; other site 604162003892 motif III; other site 604162003893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 604162003894 nucleotide binding region [chemical binding]; other site 604162003895 ATP-binding site [chemical binding]; other site 604162003896 Transposon insertion site of 90/5 mutant 604162003897 Transposon insertion site of 27/30 mutant 604162003898 Transposon insertion site of 53/9 mutant 604162003899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162003900 S-adenosylmethionine binding site [chemical binding]; other site 604162003901 Transposon insertion site of 53/43 mutant 604162003902 Transposon insertion site of 52/43 mutant 604162003903 Transposon insertion site of 31/43 mutant 604162003904 Transposon insertion site of 66/14 mutant 604162003905 Transposon insertion site of 19/48 mutant 604162003906 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 604162003907 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 604162003908 catalytic residues [active] 604162003909 Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846 604162003910 Hemerythrin-like domain; Region: Hr-like; cd12108 604162003911 Fe binding site [ion binding]; other site 604162003912 Transposon insertion site of 12/6 mutant 604162003913 Transposon insertion site of 21/28 mutant 604162003914 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 604162003915 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 604162003916 homodimer interface [polypeptide binding]; other site 604162003917 NAD binding pocket [chemical binding]; other site 604162003918 ATP binding pocket [chemical binding]; other site 604162003919 Mg binding site [ion binding]; other site 604162003920 active-site loop [active] 604162003921 Transposon insertion site of 40/17 mutant 604162003922 Transposon insertion site of 84/3 mutant 604162003923 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 604162003924 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 604162003925 generic binding surface II; other site 604162003926 generic binding surface I; other site 604162003927 Transposon insertion site of 6/23 mutant 604162003928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 604162003929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 604162003930 putative substrate translocation pore; other site 604162003931 Transposon insertion site of 74/48 mutant 604162003932 Transposon insertion site of 46/17 mutant 604162003933 Transposon insertion site of 67/6 mutant 604162003934 Transposon insertion site of 11/35 mutant 604162003935 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 604162003936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 604162003937 RNA binding surface [nucleotide binding]; other site 604162003938 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 604162003939 probable active site [active] 604162003940 Transposon insertion site of 44/9 mutant 604162003941 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 604162003942 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 604162003943 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 604162003944 Transposon insertion site of 19/10 mutant 604162003945 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 604162003946 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 604162003947 catalytic loop [active] 604162003948 iron binding site [ion binding]; other site 604162003949 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 604162003950 FAD binding pocket [chemical binding]; other site 604162003951 FAD binding motif [chemical binding]; other site 604162003952 phosphate binding motif [ion binding]; other site 604162003953 beta-alpha-beta structure motif; other site 604162003954 NAD binding pocket [chemical binding]; other site 604162003955 Transposon insertion site of 32/15 mutant 604162003956 Transposon insertion site of 90/18 mutant 604162003957 Transposon insertion site of 65/20 mutant 604162003958 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 604162003959 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 604162003960 GatB domain; Region: GatB_Yqey; smart00845 604162003961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 604162003962 Transposon insertion site of 43/27 mutant 604162003963 Transposon insertion site of 54/22 mutant 604162003964 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 604162003965 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 604162003966 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 604162003967 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 604162003968 Transposon insertion site of 88/29 mutant 604162003969 Transposon insertion site of 41/42 mutant 604162003970 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 604162003971 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 604162003972 NAD(P) binding site [chemical binding]; other site 604162003973 catalytic residues [active] 604162003974 Transposon insertion site of 32/28 mutant 604162003975 Transposon insertion site of 2/36 mutant 604162003976 Transposon insertion site of 74/31 mutant 604162003977 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 604162003978 Transposon insertion site of 82/22 mutant 604162003979 16S rRNA methyltransferase B; Provisional; Region: PRK10901 604162003980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162003981 S-adenosylmethionine binding site [chemical binding]; other site 604162003982 Transposon insertion site of 13/32 mutant 604162003983 Transposon insertion site of 36/32 mutant 604162003984 Transposon insertion site of 78/43 mutant 604162003985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3782 604162003986 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 604162003987 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 604162003988 Transposon insertion site of 19/28 mutant 604162003989 Transposon insertion site of 21/22 mutant 604162003990 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 604162003991 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 604162003992 active site 604162003993 dimerization interface [polypeptide binding]; other site 604162003994 Transposon insertion site of 45/32 mutant 604162003995 Evidence 2b : Function of strongly homologous gene; Product type prc : putative receptor 604162003996 Transposon insertion site of 82/38 mutant 604162003997 Transposon insertion site of 1/31 mutant 604162003998 Transposon insertion site of 83/36 mutant 604162003999 Evidence 2b : Function of strongly homologous gene; Product type prc : putative receptor 604162004000 Transposon insertion site of 23/44 mutant 604162004001 Transposon insertion site of 89/41 mutant 604162004002 Transposon insertion site of 50/33 mutant 604162004003 Transposon insertion site of 1/25 mutant 604162004004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 604162004005 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 604162004006 Transposon insertion site of 61/1 mutant 604162004007 Transposon insertion site of 84/7 mutant 604162004008 Transposon insertion site of 75/38 mutant 604162004009 Transposon insertion site of 90/14 mutant 604162004010 Transposon insertion site of 42/14 mutant 604162004011 Transposon insertion site of 11/11 mutant 604162004012 Transposon insertion site of 78/31 mutant 604162004013 Transposon insertion site of 49/47 mutant 604162004014 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 604162004015 E3 interaction surface; other site 604162004016 lipoyl attachment site [posttranslational modification]; other site 604162004017 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 604162004018 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 604162004019 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 604162004020 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 604162004021 Transposon insertion site of 22/34 mutant 604162004022 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 604162004023 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 604162004024 E3 interaction surface; other site 604162004025 lipoyl attachment site [posttranslational modification]; other site 604162004026 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 604162004027 E3 interaction surface; other site 604162004028 lipoyl attachment site [posttranslational modification]; other site 604162004029 e3 binding domain; Region: E3_binding; pfam02817 604162004030 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 604162004031 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 604162004032 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 604162004033 dimer interface [polypeptide binding]; other site 604162004034 TPP-binding site [chemical binding]; other site 604162004035 Transposon insertion site of 69/1 mutant 604162004036 Transposon insertion site of 55/34 mutant 604162004037 prolyl-tRNA synthetase; Provisional; Region: PRK09194 604162004038 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 604162004039 dimer interface [polypeptide binding]; other site 604162004040 motif 1; other site 604162004041 active site 604162004042 motif 2; other site 604162004043 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 604162004044 putative deacylase active site [active] 604162004045 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 604162004046 active site 604162004047 motif 3; other site 604162004048 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 604162004049 anticodon binding site; other site 604162004050 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 604162004051 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 604162004052 Transposon insertion site of 38/18 mutant 604162004053 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 604162004054 Putative transcriptional regulator [Transcription]; Region: COG1678 604162004055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 604162004056 CreA protein; Region: CreA; pfam05981 604162004057 Transposon insertion site of 43/34 mutant 604162004058 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 604162004059 Peptidase family M23; Region: Peptidase_M23; pfam01551 604162004060 Transposon insertion site of 8/3 mutant 604162004061 Transposon insertion site of 25/42 mutant 604162004062 Transposon insertion site of 82/2 mutant 604162004063 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 604162004064 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 604162004065 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 604162004066 protein binding site [polypeptide binding]; other site 604162004067 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 604162004068 Catalytic dyad [active] 604162004069 Transposon insertion site of 48/17 mutant 604162004070 Transposon insertion site of 23/2 mutant 604162004071 Transposon insertion site of 91/15 mutant 604162004072 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 604162004073 excinuclease ABC subunit B; Provisional; Region: PRK05298 604162004074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 604162004075 ATP-binding site [chemical binding]; other site 604162004076 ATP binding site [chemical binding]; other site 604162004077 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 604162004078 nucleotide binding region [chemical binding]; other site 604162004079 ATP-binding site [chemical binding]; other site 604162004080 Ultra-violet resistance protein B; Region: UvrB; pfam12344 604162004081 UvrB/uvrC motif; Region: UVR; pfam02151 604162004082 Transposon insertion site of 52/13 mutant 604162004083 Transposon insertion site of 43/4 mutant 604162004084 Transposon insertion site of 57/22 mutant 604162004085 Transposon insertion site of 11/43 mutant 604162004086 Transposon insertion site of 79/19 mutant 604162004087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162004088 S-adenosylmethionine binding site [chemical binding]; other site 604162004089 Transposon insertion site of 96/42 mutant 604162004090 Transposon insertion site of 85/13 mutant 604162004091 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 604162004092 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 604162004093 Sel1-like repeats; Region: SEL1; smart00671 604162004094 Sel1-like repeats; Region: SEL1; smart00671 604162004095 Sel1-like repeats; Region: SEL1; smart00671 604162004096 Transposon insertion site of 3/5 mutant 604162004097 Transposon insertion site of 43/11 mutant 604162004098 Transposon insertion site of 68/8 mutant 604162004099 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 604162004100 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 604162004101 GIY-YIG motif/motif A; other site 604162004102 active site 604162004103 catalytic site [active] 604162004104 putative DNA binding site [nucleotide binding]; other site 604162004105 metal binding site [ion binding]; metal-binding site 604162004106 UvrB/uvrC motif; Region: UVR; pfam02151 604162004107 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 604162004108 Helix-hairpin-helix motif; Region: HHH; pfam00633 604162004109 Transposon insertion site of 63/12 mutant 604162004110 Transposon insertion site of 50/26 mutant 604162004111 Transposon insertion site of 80/20 mutant 604162004112 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 604162004113 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 604162004114 metal-binding site [ion binding] 604162004115 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 604162004116 Soluble P-type ATPase [General function prediction only]; Region: COG4087 604162004117 Transposon insertion site of 39/17 mutant 604162004118 Transposon insertion site of 53/35 mutant 604162004119 Transposon insertion site of 54/32 mutant 604162004120 Transposon insertion site of 95/15 mutant 604162004121 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 604162004122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 604162004123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 604162004124 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 604162004125 Primosomal replication protein N [DNA replication, recombination, and repair]; Region: PriB; COG2965 604162004126 generic binding surface I; other site 604162004127 generic binding surface II; other site 604162004128 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 604162004129 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 604162004130 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 604162004131 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 604162004132 Transposon insertion site of 19/17 mutant 604162004133 Transposon insertion site of 69/11 mutant 604162004134 Transposon insertion site of 25/38 mutant 604162004135 Transposon insertion site of 85/23 mutant 604162004136 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 604162004137 Transposon insertion site of 62/30 mutant 604162004138 Transposon insertion site of 7/14 mutant 604162004139 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 604162004140 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 604162004141 Transposon insertion site of 14/27 mutant 604162004142 Transposon insertion site of 54/24 mutant 604162004143 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 604162004144 Transposon insertion site of 43/19 mutant 604162004145 Transposon insertion site of 87/42 mutant 604162004146 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 604162004147 Transposon insertion site of 10/22 mutant 604162004148 Transposon insertion site of 40/6 mutant 604162004149 Transposon insertion site of 51/32 mutant 604162004150 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 604162004151 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 604162004152 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 604162004153 Transposon insertion site of 36/9 mutant 604162004154 Transposon insertion site of 87/8 mutant 604162004155 trigger factor; Provisional; Region: tig; PRK01490 604162004156 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 604162004157 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 604162004158 Transposon insertion site of 86/15 mutant 604162004159 Transposon insertion site of 40/21 mutant 604162004160 Transposon insertion site of 85/44 mutant 604162004161 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 604162004162 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 604162004163 oligomer interface [polypeptide binding]; other site 604162004164 active site residues [active] 604162004165 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 604162004166 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 604162004167 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 604162004168 Transposon insertion site of 37/13 mutant 604162004169 Transposon insertion site of 79/43 mutant 604162004170 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 604162004171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 604162004172 binding surface 604162004173 TPR motif; other site 604162004174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 604162004175 TPR motif; other site 604162004176 binding surface 604162004177 Transposon insertion site of 86/43 mutant 604162004178 Transposon insertion site of 70/3 mutant 604162004179 Transposon insertion site of 96/4 mutant 604162004180 Transposon insertion site of 19/4 mutant 604162004181 Transposon insertion site of 30/38 mutant 604162004182 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 604162004183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 604162004184 FeS/SAM binding site; other site 604162004185 Transposon insertion site of 63/32 mutant 604162004186 Transposon insertion site of 64/8 mutant 604162004187 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 604162004188 active site 604162004189 multimer interface [polypeptide binding]; other site 604162004190 Transposon insertion site of 14/9 mutant 604162004191 Predicted ATPase [General function prediction only]; Region: COG1485 604162004192 Transposon insertion site of 22/46 mutant 604162004193 Transposon insertion site of 86/25 mutant 604162004194 Transposon insertion site of 1/5 mutant 604162004195 Transposon insertion site of 10/15 mutant 604162004196 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 604162004197 S-formylglutathione hydrolase; Region: PLN02442 604162004198 Transposon insertion site of 43/7 mutant 604162004199 Transposon insertion site of 21/38 mutant 604162004200 Transposon insertion site of 13/44 mutant 604162004201 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 604162004202 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 604162004203 substrate binding site [chemical binding]; other site 604162004204 catalytic Zn binding site [ion binding]; other site 604162004205 NAD binding site [chemical binding]; other site 604162004206 structural Zn binding site [ion binding]; other site 604162004207 dimer interface [polypeptide binding]; other site 604162004208 Transposon insertion site of 46/39 mutant 604162004209 Transposon insertion site of 18/25 mutant 604162004210 Transposon insertion site of 94/48 mutant 604162004211 Transposon insertion site of 34/26 mutant 604162004212 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 604162004213 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 604162004214 DNA binding residues [nucleotide binding] 604162004215 putative dimer interface [polypeptide binding]; other site 604162004216 Transposon insertion site of 1093/1 mutant 604162004217 Transposon insertion site of 60/11 mutant 604162004218 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 604162004219 IHF dimer interface [polypeptide binding]; other site 604162004220 IHF - DNA interface [nucleotide binding]; other site 604162004221 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 604162004222 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 604162004223 RNA binding site [nucleotide binding]; other site 604162004224 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 604162004225 RNA binding site [nucleotide binding]; other site 604162004226 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 604162004227 RNA binding site [nucleotide binding]; other site 604162004228 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 604162004229 RNA binding site [nucleotide binding]; other site 604162004230 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 604162004231 RNA binding site [nucleotide binding]; other site 604162004232 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 604162004233 RNA binding site [nucleotide binding]; other site 604162004234 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 604162004235 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 604162004236 CMP-binding site; other site 604162004237 The sites determining sugar specificity; other site 604162004238 Evidence 2b : Function of strongly homologous gene; Product type pt : putative transporter 604162004239 Transposon insertion site of 76/19 mutant 604162004240 Transposon insertion site of 25/25 mutant 604162004241 Evidence 2b : Function of strongly homologous gene; Product type pt : putative transporter 604162004242 Evidence 2b : Function of strongly homologous gene; Product type pt : putative transporter 604162004243 Transposon insertion site of 14/21 mutant 604162004244 Transposon insertion site of 50/24 mutant 604162004245 Transposon insertion site of 26/44 mutant 604162004246 Transposon insertion site of 75/1 mutant 604162004247 Transposon insertion site of 39/13 mutant 604162004248 Transposon insertion site of 8/24 mutant 604162004249 Transposon insertion site of 16/24 mutant 604162004250 Transposon insertion site of 78/27 mutant 604162004251 Transposon insertion site of 84/28 mutant 604162004252 Transposon insertion site of 81/30 mutant 604162004253 Transposon insertion site of 35/15 mutant 604162004254 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 604162004255 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 604162004256 RNA binding surface [nucleotide binding]; other site 604162004257 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 604162004258 active site 604162004259 uracil binding [chemical binding]; other site 604162004260 Transposon insertion site of 19/21 and 56/44 mutants 604162004261 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 604162004262 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 604162004263 N-acetyl-D-glucosamine binding site [chemical binding]; other site 604162004264 catalytic residue [active] 604162004265 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 604162004266 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 604162004267 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 604162004268 Transposon insertion site of 32/48 mutant 604162004269 Transposon insertion site of 54/30 mutant 604162004270 Transposon insertion site of 5/28 mutant 604162004271 Transposon insertion site of 79/18 mutant 604162004272 Transposon insertion site of 86/5 mutant 604162004273 Transposon insertion site of 61/39 mutant 604162004274 Transposon insertion site of 32/11 mutant 604162004275 Transposon insertion site of 61/31 mutant 604162004276 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 604162004277 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 604162004278 DNA binding site [nucleotide binding] 604162004279 catalytic residue [active] 604162004280 H2TH interface [polypeptide binding]; other site 604162004281 putative catalytic residues [active] 604162004282 turnover-facilitating residue; other site 604162004283 intercalation triad [nucleotide binding]; other site 604162004284 8OG recognition residue [nucleotide binding]; other site 604162004285 putative reading head residues; other site 604162004286 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 604162004287 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 604162004288 Transposon insertion site of 41/40 mutant 604162004289 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 604162004290 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 604162004291 putative acyl-acceptor binding pocket; other site 604162004292 Transposon insertion site of 54/35 mutant 604162004293 Transposon insertion site of 49/15 mutant 604162004294 Transposon insertion site of 29/47 mutant 604162004295 Transposon insertion site of 14/40 mutant 604162004296 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 604162004297 ATP cone domain; Region: ATP-cone; pfam03477 604162004298 Class I ribonucleotide reductase; Region: RNR_I; cd01679 604162004299 active site 604162004300 dimer interface [polypeptide binding]; other site 604162004301 catalytic residues [active] 604162004302 effector binding site; other site 604162004303 R2 peptide binding site; other site 604162004304 Abi-like protein; Region: Abi_2; cl01988 604162004305 Transposon insertion site of 28/12 mutant 604162004306 Transposon insertion site of 48/43 mutant 604162004307 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 604162004308 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 604162004309 dimer interface [polypeptide binding]; other site 604162004310 putative radical transfer pathway; other site 604162004311 diiron center [ion binding]; other site 604162004312 tyrosyl radical; other site 604162004313 Transposon insertion site of 38/31 mutant 604162004314 Transposon insertion site of 11/30 mutant 604162004315 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 604162004316 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 604162004317 catalytic loop [active] 604162004318 iron binding site [ion binding]; other site 604162004319 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 604162004320 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 604162004321 enolase; Provisional; Region: eno; PRK00077 604162004322 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 604162004323 dimer interface [polypeptide binding]; other site 604162004324 metal binding site [ion binding]; metal-binding site 604162004325 substrate binding pocket [chemical binding]; other site 604162004326 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 604162004327 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 604162004328 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 604162004329 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 604162004330 tetramerization interface [polypeptide binding]; other site 604162004331 active site 604162004332 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 604162004333 DEAD-like helicases superfamily; Region: DEXDc; smart00487 604162004334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 604162004335 ATP binding site [chemical binding]; other site 604162004336 putative Mg++ binding site [ion binding]; other site 604162004337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 604162004338 nucleotide binding region [chemical binding]; other site 604162004339 ATP-binding site [chemical binding]; other site 604162004340 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 604162004341 Transposon insertion site of 14/3 mutant 604162004342 Transposon insertion site of 70/47 mutant 604162004343 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 604162004344 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 604162004345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 604162004346 active site 604162004347 Transglycosylase SLT domain; Region: SLT_2; pfam13406 604162004348 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 604162004349 N-acetyl-D-glucosamine binding site [chemical binding]; other site 604162004350 Transposon insertion site of 43/6 mutant 604162004351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 604162004352 Transposon insertion site of 20/23 mutant 604162004353 Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389 604162004354 Transposon insertion site of 15/48 mutant 604162004355 Transposon insertion site of 31/3 mutant 604162004356 Transposon insertion site of 13/39 mutant 604162004357 Transposon insertion site of 76/46 mutant 604162004358 Transposon insertion site of 21/45 mutant 604162004359 Transposon insertion site of 79/16 mutant 604162004360 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 604162004361 Transposon insertion site of 72/8 mutant 604162004362 Transposon insertion site of 10/34 mutant 604162004363 Transposon insertion site of 63/3 mutant 604162004364 Transposon insertion site of 14/11 mutant 604162004365 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 604162004366 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 604162004367 acyl-activating enzyme (AAE) consensus motif; other site 604162004368 putative AMP binding site [chemical binding]; other site 604162004369 putative active site [active] 604162004370 putative CoA binding site [chemical binding]; other site 604162004371 Transposon insertion site of 5/39 mutant 604162004372 Transposon insertion site of 30/31 mutant 604162004373 Transposon insertion site of 17/27 mutant 604162004374 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 604162004375 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 604162004376 active site 604162004377 oxyanion hole [active] 604162004378 catalytic triad [active] 604162004379 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 604162004380 active site 604162004381 catalytic triad [active] 604162004382 oxyanion hole [active] 604162004383 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 604162004384 Transposon insertion site of 33/4 mutant 604162004385 Transposon insertion site of 91/10 mutant 604162004386 Transposon insertion site of 10/39 mutant 604162004387 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 604162004388 metal-binding site [ion binding] 604162004389 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162004390 Transposon insertion site of 7/31 mutant 604162004391 Transposon insertion site of 62/43 mutant 604162004392 Transposon insertion site of 46/48 mutant 604162004393 Transposon insertion site of 91/40 mutant 604162004394 Transposon insertion site of 8/8 mutant 604162004395 Transposon insertion site of 86/6 mutant 604162004396 Transposon insertion site of 92/12 mutant 604162004397 Transposon insertion site of 92/5 mutant 604162004398 Transposon insertion site of 82/34 mutant 604162004399 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162004400 Transposon insertion site of 24/12 mutant 604162004401 Transposon insertion site of 2/12 mutant 604162004402 Transposon insertion site of 42/11 mutant 604162004403 Transposon insertion site of 66/19 mutant 604162004404 Transposon insertion site of 4/48 mutant 604162004405 glycerate kinase; Region: TIGR00045 604162004406 Transposon insertion site of 9/41 mutant 604162004407 Transposon insertion site of 15/35 mutant 604162004408 Transposon insertion site of 52/34 mutant 604162004409 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 604162004410 Low molecular weight phosphatase family; Region: LMWPc; cd00115 604162004411 active site 604162004412 Transposon insertion site of 75/24 mutant 604162004413 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 604162004414 metal binding site 2 [ion binding]; metal-binding site 604162004415 putative DNA binding helix; other site 604162004416 metal binding site 1 [ion binding]; metal-binding site 604162004417 dimer interface [polypeptide binding]; other site 604162004418 structural Zn2+ binding site [ion binding]; other site 604162004419 Transposon insertion site of 1134/1 mutant 604162004420 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 604162004421 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 604162004422 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 604162004423 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 604162004424 substrate binding site [chemical binding]; other site 604162004425 Transposon insertion site of 33/13 mutant 604162004426 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162004427 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162004428 Transposon insertion site of 27/23 mutant 604162004429 Transposon insertion site of 55/16 mutant 604162004430 Transposon insertion site of 87/30 mutant 604162004431 Transposon insertion site of 30/36 mutant 604162004432 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 604162004433 Transposon insertion site of 77/2 mutant 604162004434 Transposon insertion site of 8/43 mutant 604162004435 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 604162004436 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 604162004437 Ligand Binding Site [chemical binding]; other site 604162004438 Transposon insertion site of 88/3 mutant 604162004439 Transposon insertion site of 20/30 mutant 604162004440 Transposon insertion site of 95/25 mutant 604162004441 Transposon insertion site of 50/29 mutant 604162004442 Transposon insertion site of 22/8 mutant 604162004443 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 604162004444 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 604162004445 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 604162004446 homotrimer interaction site [polypeptide binding]; other site 604162004447 putative active site [active] 604162004448 Transposon insertion site of 72/38 mutant 604162004449 Transposon insertion site of 16/23 mutant 604162004450 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 604162004451 putative deacylase active site [active] 604162004452 Transposon insertion site of 38/7 mutant 604162004453 Transposon insertion site of 61/24 mutant 604162004454 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 604162004455 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 604162004456 HSP70 interaction site [polypeptide binding]; other site 604162004457 Predicted membrane protein [Function unknown]; Region: COG3671 604162004458 Transposon insertion site of 76/29 and 85/46 mutants 604162004459 Transposon insertion site of 5/35 mutant 604162004460 Transposon insertion site of 11/27 mutant 604162004461 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 604162004462 Aspartase; Region: Aspartase; cd01357 604162004463 active sites [active] 604162004464 tetramer interface [polypeptide binding]; other site 604162004465 Transposon insertion site of 44/45 mutant 604162004466 Transposon insertion site of 19/34 mutant 604162004467 Transposon insertion site of 40/46 mutant 604162004468 Transposon insertion site of 52/9 mutant 604162004469 Transposon insertion site of 64/3 mutant 604162004470 Transposon insertion site of 41/1 mutant 604162004471 Transposon insertion site of 8/2 mutant 604162004472 Transposon insertion site of 76/18 mutant 604162004473 Uncharacterized conserved protein [Function unknown]; Region: COG2353 604162004474 Transposon insertion site of 61/47 mutant 604162004475 Transposon insertion site of 75/33 mutant 604162004476 Transposon insertion site of 65/3 mutant 604162004477 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 604162004478 tartrate dehydrogenase; Region: TTC; TIGR02089 604162004479 Transposon insertion site of 77/24 mutant 604162004480 Transposon insertion site of 23/14 mutant 604162004481 Transposon insertion site of 4/9 mutant 604162004482 Transposon insertion site of 40/35 mutant 604162004483 Domain of unknown function (DUF386); Region: DUF386; cl01047 604162004484 Transposon insertion site of 31/27 mutant 604162004485 Transposon insertion site of 42/30 mutant 604162004486 Transposon insertion site of 17/11 mutant 604162004487 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 604162004488 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 604162004489 substrate binding site [chemical binding]; other site 604162004490 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 604162004491 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 604162004492 substrate binding site [chemical binding]; other site 604162004493 ligand binding site [chemical binding]; other site 604162004494 Transposon insertion site of 68/2 mutant 604162004495 Glutamate-cysteine ligase; Region: GshA; pfam08886 604162004496 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 604162004497 Transposon insertion site of 80/43 mutant 604162004498 Transposon insertion site of 47/6 mutant 604162004499 hypothetical protein; Reviewed; Region: PRK00024 604162004500 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 604162004501 MPN+ (JAMM) motif; other site 604162004502 Zinc-binding site [ion binding]; other site 604162004503 Transposon insertion site of 4/45 mutant 604162004504 Transposon insertion site of 3/36 mutant 604162004505 Transposon insertion site of 21/11 mutant 604162004506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 604162004507 Transposon insertion site of 81/6 mutant 604162004508 Transposon insertion site of 68/37 mutant 604162004509 Transposon insertion site of 53/1 mutant 604162004510 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 604162004511 Transposon insertion site of 66/43 mutant 604162004512 Transposon insertion site of 18/14 mutant 604162004513 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 604162004514 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 604162004515 HflX GTPase family; Region: HflX; cd01878 604162004516 G1 box; other site 604162004517 GTP/Mg2+ binding site [chemical binding]; other site 604162004518 Switch I region; other site 604162004519 G2 box; other site 604162004520 G3 box; other site 604162004521 Switch II region; other site 604162004522 G4 box; other site 604162004523 G5 box; other site 604162004524 Transposon insertion site of 72/30 mutant 604162004525 Transposon insertion site of 9/15 mutant 604162004526 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 604162004527 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 604162004528 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 604162004529 metal-binding site [ion binding] 604162004530 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 604162004531 Soluble P-type ATPase [General function prediction only]; Region: COG4087 604162004532 Transposon insertion site of 54/1 mutant 604162004533 Transposon insertion site of 75/20 mutant 604162004534 Transposon insertion site of 3/20 mutant 604162004535 Transposon insertion site of 55/27 mutant 604162004536 Transposon insertion site of 50/48 mutant 604162004537 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 604162004538 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 604162004539 FAD binding pocket [chemical binding]; other site 604162004540 FAD binding motif [chemical binding]; other site 604162004541 phosphate binding motif [ion binding]; other site 604162004542 beta-alpha-beta structure motif; other site 604162004543 NAD binding pocket [chemical binding]; other site 604162004544 Transposon insertion site of 34/6 mutant 604162004545 Transposon insertion site of 21/31 mutant 604162004546 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 604162004547 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 604162004548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162004549 catalytic residue [active] 604162004550 Transposon insertion site of 87/24 mutant 604162004551 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 604162004552 Transposon insertion site of 30/15 mutant 604162004553 Transposon insertion site of 89/6 mutant 604162004554 Transposon insertion site of 15/6 mutant 604162004555 Transposon insertion site of 26/16 mutant 604162004556 Transposon insertion site of 95/29 mutant 604162004557 Transposon insertion site of 93/29 mutant 604162004558 Transposon insertion site of 53/2 mutant 604162004559 Transposon insertion site of 26/43 mutant 604162004560 Transposon insertion site of 25/37 mutant 604162004561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 604162004562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 604162004563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 604162004564 dimerization interface [polypeptide binding]; other site 604162004565 Transposon insertion site of 62/6 mutant 604162004566 Transposon insertion site of 55/12 mutant 604162004567 Transposon insertion site of 45/11 mutant 604162004568 Transposon insertion site of 64/13 mutant 604162004569 Transposon insertion site of 7/2 mutant 604162004570 Transposon insertion site of 37/24 mutant 604162004571 Transposon insertion site of 45/44 mutant 604162004572 Transposon insertion site of 19/6 mutant 604162004573 Transposon insertion site of 84/5 mutant 604162004574 Transposon insertion site of 70/5 mutant 604162004575 Transposon insertion site of 90/47 mutant 604162004576 Transposon insertion site of 23/17 mutant 604162004577 recombination factor protein RarA; Reviewed; Region: PRK13342 604162004578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162004579 Walker A motif; other site 604162004580 ATP binding site [chemical binding]; other site 604162004581 Walker B motif; other site 604162004582 arginine finger; other site 604162004583 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 604162004584 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 604162004585 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 604162004586 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 604162004587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 604162004588 ATP binding site [chemical binding]; other site 604162004589 putative Mg++ binding site [ion binding]; other site 604162004590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 604162004591 nucleotide binding region [chemical binding]; other site 604162004592 Transposon insertion site of 57/44 mutant 604162004593 Transposon insertion site of 15/44 mutant 604162004594 Transposon insertion site of 28/6 mutant 604162004595 Transposon insertion site of 84/12 mutant 604162004596 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 604162004597 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 604162004598 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 604162004599 Transposon insertion site of 77/40 mutant 604162004600 Transposon insertion site of 16/47 mutant 604162004601 Transposon insertion site of 61/41 mutant 604162004602 Transposon insertion site of 80/22 mutant 604162004603 Transposon insertion site of 18/43 mutant 604162004604 Transposon insertion site of 78/15 mutant 604162004605 Transposon insertion site of 55/22 mutant 604162004606 Transposon insertion site of 96/36 mutant 604162004607 Transposon insertion site of 95/26 mutant 604162004608 Transposon insertion site of 19/37 mutant 604162004609 Transposon insertion site of 58/23 mutant 604162004610 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 604162004611 Transposon insertion site of 89/40 mutant 604162004612 Transposon insertion site of 42/39 mutant 604162004613 Transposon insertion site of 29/8 mutant 604162004614 Transposon insertion site of 55/41 mutant 604162004615 Transposon insertion site of 57/30 mutant 604162004616 Transposon insertion site of 25/34 mutant 604162004617 Transposon insertion site of 6/22 mutant 604162004618 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 604162004619 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 604162004620 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 604162004621 dimerization interface [polypeptide binding]; other site 604162004622 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162004623 Transposon insertion site of 43/45 mutant 604162004624 Transposon insertion site of 42/9 mutant 604162004625 Transposon insertion site of 41/19 mutant 604162004626 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162004627 Transposon insertion site of 47/38 mutant 604162004628 Transposon insertion site of 33/21 mutant 604162004629 Transposon insertion site of 81/44 mutant 604162004630 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 604162004631 dimerization interface [polypeptide binding]; other site 604162004632 active site 604162004633 Transposon insertion site of 91/3 mutant 604162004634 Transposon insertion site of 40/27 mutant 604162004635 Transposon insertion site of 81/29 mutant 604162004636 Transposon insertion site of 42/44 mutant 604162004637 Transposon insertion site of 28/29 mutant 604162004638 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 604162004639 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 604162004640 dimerization interface [polypeptide binding]; other site 604162004641 putative ATP binding site [chemical binding]; other site 604162004642 Transposon insertion site of 7/5 mutant 604162004643 Transposon insertion site of 88/37 mutant 604162004644 Transposon insertion site of 83/3 mutant 604162004645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 604162004646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 604162004647 active site 604162004648 phosphorylation site [posttranslational modification] 604162004649 intermolecular recognition site; other site 604162004650 dimerization interface [polypeptide binding]; other site 604162004651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 604162004652 DNA binding residues [nucleotide binding] 604162004653 dimerization interface [polypeptide binding]; other site 604162004654 Transposon insertion site of 47/30 mutant 604162004655 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 604162004656 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 604162004657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 604162004658 dimerization interface [polypeptide binding]; other site 604162004659 GAF domain; Region: GAF_3; pfam13492 604162004660 Histidine kinase; Region: HisKA_3; pfam07730 604162004661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 604162004662 ATP binding site [chemical binding]; other site 604162004663 Mg2+ binding site [ion binding]; other site 604162004664 G-X-G motif; other site 604162004665 Transposon insertion site of 87/16 mutant 604162004666 Transposon insertion site of 84/36 mutant 604162004667 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 604162004668 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 604162004669 GTP binding site; other site 604162004670 Transposon insertion site of 10/20 mutant 604162004671 Transposon insertion site of 38/30 mutant 604162004672 Transposon insertion site of 32/34 mutant 604162004673 Transposon insertion site of 20/33 mutant 604162004674 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 604162004675 Lumazine binding domain; Region: Lum_binding; pfam00677 604162004676 Lumazine binding domain; Region: Lum_binding; pfam00677 604162004677 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 604162004678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162004679 Walker A motif; other site 604162004680 ATP binding site [chemical binding]; other site 604162004681 Walker B motif; other site 604162004682 Transposon insertion site of 57/46 mutant 604162004683 Transposon insertion site of 7/47 mutant 604162004684 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678 604162004685 dimer interface [polypeptide binding]; other site 604162004686 Transposon insertion site of 80/45 mutant 604162004687 Transposon insertion site of 86/24 mutant 604162004688 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 604162004689 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 604162004690 substrate binding site [chemical binding]; other site 604162004691 hexamer interface [polypeptide binding]; other site 604162004692 metal binding site [ion binding]; metal-binding site 604162004693 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 604162004694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162004695 Walker A motif; other site 604162004696 ATP binding site [chemical binding]; other site 604162004697 Walker B motif; other site 604162004698 arginine finger; other site 604162004699 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 604162004700 Transposon insertion site of 46/11 mutant 604162004701 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 604162004702 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 604162004703 active site 604162004704 NTP binding site [chemical binding]; other site 604162004705 metal binding triad [ion binding]; metal-binding site 604162004706 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 604162004707 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 604162004708 Zn2+ binding site [ion binding]; other site 604162004709 Mg2+ binding site [ion binding]; other site 604162004710 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 604162004711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 604162004712 Walker A/P-loop; other site 604162004713 ATP binding site [chemical binding]; other site 604162004714 ABC transporter signature motif; other site 604162004715 Walker B; other site 604162004716 D-loop; other site 604162004717 H-loop/switch region; other site 604162004718 ABC transporter; Region: ABC_tran_2; pfam12848 604162004719 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 604162004720 Transposon insertion site of 50/21 mutant 604162004721 Transposon insertion site of 18/21 mutant 604162004722 Transposon insertion site of 10/42 mutant 604162004723 Transposon insertion site of 61/25 mutant 604162004724 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 604162004725 ArsC family; Region: ArsC; pfam03960 604162004726 putative catalytic residues [active] 604162004727 Transposon insertion site of 12/31 mutant 604162004728 SurA N-terminal domain; Region: SurA_N_3; cl07813 604162004729 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 604162004730 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 604162004731 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 604162004732 RecR protein; Region: RecR; pfam02132 604162004733 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 604162004734 putative active site [active] 604162004735 putative metal-binding site [ion binding]; other site 604162004736 tetramer interface [polypeptide binding]; other site 604162004737 Transposon insertion site of 75/8 mutant 604162004738 Transposon insertion site of 71/47 mutant 604162004739 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 604162004740 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 604162004741 FtsX-like permease family; Region: FtsX; pfam02687 604162004742 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 604162004743 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 604162004744 Walker A/P-loop; other site 604162004745 ATP binding site [chemical binding]; other site 604162004746 Q-loop/lid; other site 604162004747 ABC transporter signature motif; other site 604162004748 Walker B; other site 604162004749 D-loop; other site 604162004750 H-loop/switch region; other site 604162004751 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 604162004752 AAA domain; Region: AAA_30; pfam13604 604162004753 Family description; Region: UvrD_C_2; pfam13538 604162004754 Transposon insertion site of 14/39 mutant 604162004755 Transposon insertion site of 31/25 mutant 604162004756 Methyltransferase domain; Region: Methyltransf_23; pfam13489 604162004757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162004758 S-adenosylmethionine binding site [chemical binding]; other site 604162004759 Transposon insertion site of 41/48 mutant 604162004760 Transposon insertion site of 54/44 mutant 604162004761 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 604162004762 Found in ATP-dependent protease La (LON); Region: LON; smart00464 604162004763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162004764 Walker A motif; other site 604162004765 ATP binding site [chemical binding]; other site 604162004766 Walker B motif; other site 604162004767 arginine finger; other site 604162004768 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 604162004769 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 604162004770 IHF dimer interface [polypeptide binding]; other site 604162004771 IHF - DNA interface [nucleotide binding]; other site 604162004772 homoserine dehydrogenase; Provisional; Region: PRK06349 604162004773 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 604162004774 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 604162004775 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 604162004776 Transposon insertion site of 16/37 mutant 604162004777 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 604162004778 Transposon insertion site of 74/23 mutant 604162004779 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 604162004780 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 604162004781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 604162004782 ABC transporter; Region: ABC_tran_2; pfam12848 604162004783 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 604162004784 Transposon insertion site of 26/30 mutant 604162004785 Transposon insertion site of 11/31 mutant 604162004786 Transposon insertion site of 44/32 mutant 604162004787 Transposon insertion site of 88/44 mutant 604162004788 Transposon insertion site of 60/48 mutant 604162004789 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 604162004790 Transposon insertion site of 79/48 mutant 604162004791 Transposon insertion site of 84/23 mutant 604162004792 Transposon insertion site of 46/4 mutant 604162004793 Transposon insertion site of 14/44 and 92/32 mutants 604162004794 Transposon insertion site of 87/18 mutant 604162004795 Transposon insertion site of 44/19 mutant 604162004796 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162004797 Transposon insertion site of 90/31 mutant 604162004798 Transposon insertion site of 38/12 mutant 604162004799 Transposon insertion site of 32/33 mutant 604162004800 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162004801 Transposon insertion site of 90/6 mutant 604162004802 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162004803 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162004804 Transposon insertion site of 30/2 mutant 604162004805 Transposon insertion site of 83/38 mutant 604162004806 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 604162004807 ligand binding site [chemical binding]; other site 604162004808 active site 604162004809 UGI interface [polypeptide binding]; other site 604162004810 catalytic site [active] 604162004811 Transposon insertion site of 71/16 mutant 604162004812 Transposon insertion site of 74/42 mutant 604162004813 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 604162004814 Transposon insertion site of 32/31 mutant 604162004815 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 604162004816 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 604162004817 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 604162004818 Domain of unknown function DUF20; Region: UPF0118; pfam01594 604162004819 Transposon insertion site of 74/27 mutant 604162004820 Transposon insertion site of 74/45 mutant 604162004821 Uncharacterized conserved protein [Function unknown]; Region: COG2921 604162004822 Transposon insertion site of 70/9 mutant 604162004823 lipoate-protein ligase B; Provisional; Region: PRK14342 604162004824 lipoyl synthase; Provisional; Region: PRK05481 604162004825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 604162004826 FeS/SAM binding site; other site 604162004827 Transposon insertion site of 76/15 mutant 604162004828 Transposon insertion site of 30/34 mutant 604162004829 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 604162004830 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 604162004831 heme binding site [chemical binding]; other site 604162004832 ferroxidase pore; other site 604162004833 ferroxidase diiron center [ion binding]; other site 604162004834 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 604162004835 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 604162004836 heme binding site [chemical binding]; other site 604162004837 ferroxidase pore; other site 604162004838 ferroxidase diiron center [ion binding]; other site 604162004839 Transposon insertion site of 73/36 mutant 604162004840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 604162004841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 604162004842 non-specific DNA binding site [nucleotide binding]; other site 604162004843 salt bridge; other site 604162004844 sequence-specific DNA binding site [nucleotide binding]; other site 604162004845 Transposon insertion site of 72/47 mutant 604162004846 Transposon insertion site of 95/8 mutant 604162004847 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 604162004848 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 604162004849 metal binding triad; other site 604162004850 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 604162004851 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 604162004852 Zn2+ binding site [ion binding]; other site 604162004853 Mg2+ binding site [ion binding]; other site 604162004854 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 604162004855 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 604162004856 Transposon insertion site of 47/9 mutant 604162004857 Transposon insertion site of 60/47 mutant 604162004858 Transposon insertion site of 72/48 mutant 604162004859 Transposon insertion site of 44/14 mutant 604162004860 Transposon insertion site of 27/42 mutant 604162004861 Transposon insertion site of 11/32 mutant 604162004862 Transposon insertion site of 63/21 mutant 604162004863 Transposon insertion site of 62/20 mutant 604162004864 Transposon insertion site of 70/29 mutant 604162004865 Transposon insertion site of 82/21 mutant 604162004866 Transposon insertion site of 3/13 mutant 604162004867 Transposon insertion site of 34/13 mutant 604162004868 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 604162004869 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 604162004870 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 604162004871 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 604162004872 active site 604162004873 Transposon insertion site of 65/17 mutant 604162004874 ribonuclease R; Region: RNase_R; TIGR02063 604162004875 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 604162004876 RNB domain; Region: RNB; pfam00773 604162004877 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 604162004878 RNA binding site [nucleotide binding]; other site 604162004879 Transposon insertion site of 58/12 mutant 604162004880 Transposon insertion site of 93/7 mutant 604162004881 Transposon insertion site of 2/42 mutant 604162004882 Transposon insertion site of 81/16 mutant 604162004883 Transposon insertion site of 77/16 mutant 604162004884 Transposon insertion site of 32/12 mutant 604162004885 Transposon insertion site of 69/16 mutant 604162004886 Transposon insertion site of 40/33 mutant 604162004887 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 604162004888 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 604162004889 G1 box; other site 604162004890 putative GEF interaction site [polypeptide binding]; other site 604162004891 GTP/Mg2+ binding site [chemical binding]; other site 604162004892 Switch I region; other site 604162004893 G2 box; other site 604162004894 G3 box; other site 604162004895 Switch II region; other site 604162004896 G4 box; other site 604162004897 G5 box; other site 604162004898 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 604162004899 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 604162004900 Transposon insertion site of 67/46 mutant 604162004901 Transposon insertion site of 92/22 mutant 604162004902 Transposon insertion site of 33/22 mutant 604162004903 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 604162004904 putative substrate binding site [chemical binding]; other site 604162004905 putative ATP binding site [chemical binding]; other site 604162004906 Transposon insertion site of 31/9 mutant 604162004907 Transposon insertion site of 8/34 mutant 604162004908 Transposon insertion site of 63/5 mutant 604162004909 Cytochrome b [Energy production and conversion]; Region: COG3658 604162004910 Transposon insertion site of 80/6 mutant 604162004911 Transposon insertion site of 60/7 mutant 604162004912 siroheme synthase; Provisional; Region: cysG; PRK10637 604162004913 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 604162004914 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 604162004915 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 604162004916 active site 604162004917 SAM binding site [chemical binding]; other site 604162004918 homodimer interface [polypeptide binding]; other site 604162004919 Transposon insertion site of 53/16 mutant 604162004920 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 604162004921 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 604162004922 Active Sites [active] 604162004923 Transposon insertion site of 8/32 mutant 604162004924 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 604162004925 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 604162004926 Active Sites [active] 604162004927 Transposon insertion site of 31/34 mutant 604162004928 Transposon insertion site of 19/29 mutant 604162004929 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 604162004930 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 604162004931 CysD dimerization site [polypeptide binding]; other site 604162004932 G1 box; other site 604162004933 putative GEF interaction site [polypeptide binding]; other site 604162004934 GTP/Mg2+ binding site [chemical binding]; other site 604162004935 Switch I region; other site 604162004936 G2 box; other site 604162004937 G3 box; other site 604162004938 Switch II region; other site 604162004939 G4 box; other site 604162004940 G5 box; other site 604162004941 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 604162004942 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 604162004943 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 604162004944 Flavodoxin; Region: Flavodoxin_1; pfam00258 604162004945 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 604162004946 FAD binding pocket [chemical binding]; other site 604162004947 FAD binding motif [chemical binding]; other site 604162004948 catalytic residues [active] 604162004949 NAD binding pocket [chemical binding]; other site 604162004950 phosphate binding motif [ion binding]; other site 604162004951 beta-alpha-beta structure motif; other site 604162004952 Transposon insertion site of 11/12 mutant 604162004953 Transposon insertion site of 4/38 mutant 604162004954 Transposon insertion site of 66/2 mutant 604162004955 Transposon insertion site of 67/3 mutant 604162004956 sulfite reductase (NADPH) hemoprotein, beta-component; Region: CysI; TIGR02041 604162004957 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 604162004958 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 604162004959 Transposon insertion site of 25/23 mutant 604162004960 Transposon insertion site of 26/5 mutant 604162004961 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 604162004962 Transposon insertion site of 24/31 mutant 604162004963 Transposon insertion site of 94/24 mutant 604162004964 Transposon insertion site of 21/39 mutant 604162004965 Transposon insertion site of 57/21 mutant 604162004966 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 604162004967 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 604162004968 Helix-turn-helix domain; Region: HTH_38; pfam13936 604162004969 Homeodomain-like domain; Region: HTH_32; pfam13565 604162004970 Integrase core domain; Region: rve; pfam00665 604162004971 Transposon insertion site of 89/23 mutant 604162004972 biotin synthase; Region: bioB; TIGR00433 604162004973 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 604162004974 FeS/SAM binding site; other site 604162004975 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 604162004976 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 604162004977 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 604162004978 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 604162004979 Transposon insertion site of 12/15 mutant 604162004980 Transposon insertion site of 64/27 mutant 604162004981 Transposon insertion site of 11/38 mutant 604162004982 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 604162004983 Transposon insertion site of 79/10 mutant 604162004984 Transposon insertion site of 87/3 mutant 604162004985 Transposon insertion site of 58/39 mutant 604162004986 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 604162004987 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 604162004988 Transposon insertion site of 49/48 mutant 604162004989 Transposon insertion site of 76/37 mutant 604162004990 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 604162004991 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 604162004992 Ligand Binding Site [chemical binding]; other site 604162004993 TilS substrate binding domain; Region: TilS; pfam09179 604162004994 TilS substrate C-terminal domain; Region: TilS_C; cl17443 604162004995 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 604162004996 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 604162004997 Transposon insertion site of 6/17 mutant 604162004998 Transposon insertion site of 27/36 mutant 604162004999 Transposon insertion site of 90/43 mutant 604162005000 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 604162005001 RNA binding surface [nucleotide binding]; other site 604162005002 Transposon insertion site of 76/13 mutant 604162005003 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 604162005004 Transposon insertion site of 18/10 mutant 604162005005 Transposon insertion site of 62/32 mutant 604162005006 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 604162005007 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 604162005008 catalytic loop [active] 604162005009 iron binding site [ion binding]; other site 604162005010 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology' 604162005011 Transposon insertion site of 59/17 mutant 604162005012 Transposon insertion site of 72/26 mutant 604162005013 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology' 604162005014 Transposon insertion site of 46/21 mutant 604162005015 Transposon insertion site of 50/34 mutant 604162005016 Transposon insertion site of 79/32 mutant 604162005017 Transposon insertion site of 86/30 mutant 604162005018 Transposon insertion site of 53/36 mutant 604162005019 Transposon insertion site of 8/20 mutant 604162005020 Transposon insertion site of 56/3 mutant 604162005021 T5orf172 domain; Region: T5orf172; pfam10544 604162005022 Transposon insertion site of 35/19 mutant 604162005023 Transposon insertion site of 12/46 mutant 604162005024 chaperone protein HscA; Provisional; Region: hscA; PRK05183 604162005025 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 604162005026 nucleotide binding site [chemical binding]; other site 604162005027 putative NEF/HSP70 interaction site [polypeptide binding]; other site 604162005028 SBD interface [polypeptide binding]; other site 604162005029 Transposon insertion site of 77/21 mutant 604162005030 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 604162005031 active site lid residues [active] 604162005032 substrate binding pocket [chemical binding]; other site 604162005033 catalytic residues [active] 604162005034 substrate-Mg2+ binding site; other site 604162005035 aspartate-rich region 1; other site 604162005036 aspartate-rich region 2; other site 604162005037 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 604162005038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 604162005039 short chain dehydrogenase; Provisional; Region: PRK08703 604162005040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 604162005041 NAD(P) binding site [chemical binding]; other site 604162005042 active site 604162005043 Transposon insertion site of 91/18 mutant 604162005044 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 604162005045 Transposon insertion site of 26/8 mutant 604162005046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 604162005047 Transposon insertion site of 1/32 mutant 604162005048 Transposon insertion site of 70/33 mutant 604162005049 Transposon insertion site of 43/17 mutant 604162005050 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 604162005051 Transposon insertion site of 85/22 mutant 604162005052 Transposon insertion site of 74/25 mutant 604162005053 Transposon insertion site of 32/45 mutant 604162005054 Transposon insertion site of 24/9 mutant 604162005055 Evidence 7 : Gene remnant; Product type pt : putative transporter 604162005056 Transposon insertion site of 3/43 mutant 604162005057 Transposon insertion site of 22/25 mutant 604162005058 Transposon insertion site of 72/45 mutant 604162005059 Transposon insertion site of 80/12 mutant 604162005060 Transposon insertion site of 88/42 mutant 604162005061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 604162005062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 604162005063 Transposon insertion site of 62/36 mutant 604162005064 Transposon insertion site of 17/28 mutant 604162005065 Phage Tail Collar Domain; Region: Collar; pfam07484 604162005066 Phage Tail Collar Domain; Region: Collar; pfam07484 604162005067 Transposon insertion site of 15/19 mutant 604162005068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 604162005069 Evidence 7 : Gene remnant; Product type ps : putative structure 604162005070 Transposon insertion site of 72/6 mutant 604162005071 Evidence 7 : Gene remnant 604162005072 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 604162005073 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 604162005074 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 604162005075 Mu-like prophage I protein [General function prediction only]; Region: COG4388 604162005076 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 604162005077 Transposon insertion site of 83/9 mutant 604162005078 Mu-like prophage protein gpG [General function prediction only]; Region: COG5005 604162005079 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 604162005080 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 604162005081 Transposon insertion site of 76/10 mutant 604162005082 Transposon insertion site of 18/31 mutant 604162005083 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 604162005084 Protein of unknown function (DUF935); Region: DUF935; pfam06074 604162005085 Transposon insertion site of 30/21 mutant 604162005086 phage uncharacterized protein (putative large terminase), C-terminal domain; Region: psiM2_ORF9; TIGR01630 604162005087 Transposon insertion site of 18/13 mutant 604162005088 Transposon insertion site of 94/35 mutant 604162005089 Transposon insertion site of 38/6 mutant 604162005090 Transposon insertion site of 22/18 mutant 604162005091 Transposon insertion site of 20/16 mutant 604162005092 Transposon insertion site of 54/5 mutant 604162005093 Transposon insertion site of 1/3 mutant 604162005094 Transposon insertion site of 87/1 mutant 604162005095 Transposon insertion site of 54/39 mutant 604162005096 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 604162005097 Transposon insertion site of 59/9 mutant 604162005098 Transposon insertion site of 95/32 mutant 604162005099 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 604162005100 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 604162005101 active site 604162005102 metal binding site [ion binding]; metal-binding site 604162005103 Mor transcription activator family; Region: Mor; cl02360 604162005104 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 604162005105 Transposon insertion site of 49/23 mutant 604162005106 Transposon insertion site of 56/37 mutant 604162005107 Transposon insertion site of 9/26 mutant 604162005108 Putative exonuclease, RdgC; Region: RdgC; cl01122 604162005109 Transposon insertion site of 83/30 mutant 604162005110 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 604162005111 Transposon insertion site of 12/20 mutant 604162005112 Eukaryotic Mediator 12 subunit domain; Region: Med12-LCEWAV; pfam12145 604162005113 DNA polymerase IV; Provisional; Region: PRK02794 604162005114 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 604162005115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 604162005116 non-specific DNA binding site [nucleotide binding]; other site 604162005117 salt bridge; other site 604162005118 sequence-specific DNA binding site [nucleotide binding]; other site 604162005119 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 604162005120 Transposon insertion site of 82/19 mutant 604162005121 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 604162005122 Integrase core domain; Region: rve; pfam00665 604162005123 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 604162005124 Transposon insertion site of 94/37 mutant 604162005125 Transposon insertion site of 54/7 mutant 604162005126 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 604162005127 non-specific DNA binding site [nucleotide binding]; other site 604162005128 salt bridge; other site 604162005129 sequence-specific DNA binding site [nucleotide binding]; other site 604162005130 Transposon insertion site of 82/36 mutant 604162005131 Transposon insertion site of 26/34 mutant 604162005132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 604162005133 non-specific DNA binding site [nucleotide binding]; other site 604162005134 salt bridge; other site 604162005135 sequence-specific DNA binding site [nucleotide binding]; other site 604162005136 ORF6C domain; Region: ORF6C; pfam10552 604162005137 Transposon insertion site of 71/12 mutant 604162005138 Transposon insertion site of 2/24 mutant 604162005139 Evidence 7 : Gene remnant; Product type pr : putative regulator 604162005140 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 604162005141 Helix-turn-helix domain; Region: HTH_38; pfam13936 604162005142 Homeodomain-like domain; Region: HTH_32; pfam13565 604162005143 Integrase core domain; Region: rve; pfam00665 604162005144 Transposon insertion site of 40/42 mutant 604162005145 Transposon insertion site of 25/32 mutant 604162005146 Evidence 7 : Gene remnant; Product type pt : putative transporter 604162005147 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 604162005148 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 604162005149 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 604162005150 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 604162005151 Transposon insertion site of 7/8 mutant 604162005152 Transposon insertion site of 69/40 mutant 604162005153 Transposon insertion site of 16/32 mutant 604162005154 Transposon insertion site of 69/24 mutant 604162005155 Transposon insertion site of 16/13 mutant 604162005156 Transposon insertion site of 5/43 mutant 604162005157 Transposon insertion site of 24/23 mutant 604162005158 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 604162005159 feedback inhibition sensing region; other site 604162005160 homohexameric interface [polypeptide binding]; other site 604162005161 nucleotide binding site [chemical binding]; other site 604162005162 N-acetyl-L-glutamate binding site [chemical binding]; other site 604162005163 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 604162005164 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 604162005165 putative active site [active] 604162005166 Zn binding site [ion binding]; other site 604162005167 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 604162005168 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 604162005169 yecA family protein; Region: ygfB_yecA; TIGR02292 604162005170 SEC-C motif; Region: SEC-C; pfam02810 604162005171 Transposon insertion site of 95/2 mutant 604162005172 Transposon insertion site of 12/3 mutant 604162005173 2-isopropylmalate synthase; Validated; Region: PRK00915 604162005174 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 604162005175 active site 604162005176 catalytic residues [active] 604162005177 metal binding site [ion binding]; metal-binding site 604162005178 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 604162005179 Transposon insertion site of 21/42 mutant 604162005180 Transposon insertion site of 20/10 mutant 604162005181 glutamate 5-kinase; Region: proB; TIGR01027 604162005182 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 604162005183 nucleotide binding site [chemical binding]; other site 604162005184 homotetrameric interface [polypeptide binding]; other site 604162005185 putative phosphate binding site [ion binding]; other site 604162005186 putative allosteric binding site; other site 604162005187 PUA domain; Region: PUA; pfam01472 604162005188 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 604162005189 putative catalytic cysteine [active] 604162005190 Transposon insertion site of 59/32 mutant 604162005191 Transposon insertion site of 60/42 mutant 604162005192 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 604162005193 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 604162005194 Transposon insertion site of 53/12 mutant 604162005195 Transposon insertion site of 30/7 mutant 604162005196 Transposon insertion site of 60/1 mutant 604162005197 Predicted membrane protein [Function unknown]; Region: COG3235 604162005198 Transposon insertion site of 87/28 mutant 604162005199 CrcB-like protein; Region: CRCB; cl09114 604162005200 Transposon insertion site of 30/17 mutant 604162005201 Transposon insertion site of 20/36 mutant 604162005202 Transposon insertion site of 18/4 mutant 604162005203 Transposon insertion site of 29/39 mutant 604162005204 Transposon insertion site of 7/38 mutant 604162005205 Transposon insertion site of 78/14 mutant 604162005206 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 604162005207 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 604162005208 dimer interface [polypeptide binding]; other site 604162005209 ADP-ribose binding site [chemical binding]; other site 604162005210 active site 604162005211 nudix motif; other site 604162005212 metal binding site [ion binding]; metal-binding site 604162005213 Transposon insertion site of 89/16 mutant 604162005214 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 604162005215 active site 604162005216 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 604162005217 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 604162005218 Transposon insertion site of 6/30 mutant 604162005219 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 604162005220 AMP binding site [chemical binding]; other site 604162005221 metal binding site [ion binding]; metal-binding site 604162005222 active site 604162005223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 604162005224 Evidence 2b : Function of strongly homologous gene; Product type pc : putative carrier 604162005225 Evidence 2b : Function of strongly homologous gene; Product type pc : putative carrier 604162005226 Transposon insertion site of 59/30 mutant 604162005227 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 604162005228 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 604162005229 Transposon insertion site of 14/8 mutant 604162005230 Transposon insertion site of 94/15 mutant 604162005231 Transposon insertion site of 5/26 and 89/34 mutants 604162005232 Transposon insertion site of 65/24 mutant 604162005233 Transposon insertion site of 92/27 mutant 604162005234 Transposon insertion site of 84/25 mutant 604162005235 Transposon insertion site of 58/43 mutant 604162005236 Transposon insertion site of 31/11 mutant 604162005237 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 604162005238 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 604162005239 dimer interface [polypeptide binding]; other site 604162005240 active site 604162005241 glycine-pyridoxal phosphate binding site [chemical binding]; other site 604162005242 folate binding site [chemical binding]; other site 604162005243 Transposon insertion site of 42/20 mutant 604162005244 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 604162005245 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 604162005246 Transposon insertion site of 19/5 mutant 604162005247 ABC transporter ATPase component; Reviewed; Region: PRK11147 604162005248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 604162005249 Walker A/P-loop; other site 604162005250 ATP binding site [chemical binding]; other site 604162005251 Q-loop/lid; other site 604162005252 ABC transporter signature motif; other site 604162005253 Walker B; other site 604162005254 D-loop; other site 604162005255 H-loop/switch region; other site 604162005256 ABC transporter; Region: ABC_tran_2; pfam12848 604162005257 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 604162005258 Transposon insertion site of 42/35 mutant 604162005259 Transposon insertion site of 2/8 mutant 604162005260 Transposon insertion site of 62/7 mutant 604162005261 Transposon insertion site of 40/10 mutant 604162005262 Transposon insertion site of 78/6 mutant 604162005263 Transposon insertion site of 34/24 mutant 604162005264 Transposon insertion site of 5/37 mutant 604162005265 anthranilate synthase component I; Provisional; Region: PRK13565 604162005266 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 604162005267 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 604162005268 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 604162005269 Transposon insertion site of 17/36 mutant 604162005270 Transposon insertion site of 15/33 mutant 604162005271 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 604162005272 XdhC Rossmann domain; Region: XdhC_C; pfam13478 604162005273 ATP-grasp domain; Region: ATP-grasp; pfam02222 604162005274 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 604162005275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 604162005276 Coenzyme A binding pocket [chemical binding]; other site 604162005277 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 604162005278 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 604162005279 Transposon insertion site of 7/26 mutant 604162005280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 604162005281 Smr domain; Region: Smr; pfam01713 604162005282 Transposon insertion site of 56/28 mutant 604162005283 Transposon insertion site of 66/25 mutant 604162005284 HTH-like domain; Region: HTH_21; pfam13276 604162005285 Integrase core domain; Region: rve; pfam00665 604162005286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 604162005287 Transposon insertion site of 14/2 mutant 604162005288 Transposon insertion site of 20/45 mutant 604162005289 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 604162005290 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 604162005291 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 604162005292 Transposon insertion site of 23/29 mutant 604162005293 Transposon insertion site of 46/41 mutant 604162005294 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 604162005295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 604162005296 non-specific DNA binding site [nucleotide binding]; other site 604162005297 salt bridge; other site 604162005298 sequence-specific DNA binding site [nucleotide binding]; other site 604162005299 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 604162005300 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme' 604162005301 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme' 604162005302 Transposon insertion site of 20/21 mutant 604162005303 Transposon insertion site of 16/38 mutant 604162005304 Transposase domain (DUF772); Region: DUF772; pfam05598 604162005305 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162005306 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 604162005307 Transposon insertion site of 80/30 mutant 604162005308 Transposon insertion site of 58/37 mutant 604162005309 Transposon insertion site of 72/9 mutant 604162005310 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 604162005311 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 604162005312 FMN binding site [chemical binding]; other site 604162005313 active site 604162005314 catalytic residues [active] 604162005315 substrate binding site [chemical binding]; other site 604162005316 Transposon insertion site of 38/34 mutant 604162005317 Transposon insertion site of 59/11 mutant 604162005318 Transposon insertion site of 14/24 mutant 604162005319 Transposon insertion site of 38/21 mutant 604162005320 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 604162005321 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 604162005322 FAD binding domain; Region: FAD_binding_4; pfam01565 604162005323 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 604162005324 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 604162005325 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 604162005326 Cysteine-rich domain; Region: CCG; pfam02754 604162005327 Cysteine-rich domain; Region: CCG; pfam02754 604162005328 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 604162005329 Transposon insertion site of 34/8 mutant 604162005330 Transposon insertion site of 62/10 mutant 604162005331 Transposon insertion site of 63/33 mutant 604162005332 Transposon insertion site of 64/33 mutant 604162005333 Transposon insertion site of 59/16 mutant 604162005334 Transposon insertion site of 6/48 mutant 604162005335 Transposon insertion site of 77/17 mutant 604162005336 Transposon insertion site of 26/29 mutant 604162005337 Transposon insertion site of 40/43 mutant 604162005338 Transposon insertion site of 68/46 mutant 604162005339 Transposon insertion site of 2/28 mutant 604162005340 Transposon insertion site of 75/43 mutant 604162005341 Transposon insertion site of 2/5 mutant 604162005342 Transposon insertion site of 22/27 mutant 604162005343 Transposon insertion site of 83/14 mutant 604162005344 Transposon insertion site of 3/45 mutant 604162005345 D-lactate dehydrogenase; Provisional; Region: PRK11183 604162005346 FAD binding domain; Region: FAD_binding_4; pfam01565 604162005347 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 604162005348 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 604162005349 Transposon insertion site of 72/10 mutant 604162005350 Uncharacterized conserved protein [Function unknown]; Region: COG2128 604162005351 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 604162005352 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162005353 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162005354 Evidence 7 : Gene remnant; Product type c : carrier 604162005355 Transposon insertion site of 82/47 mutant 604162005356 Transposon insertion site of 32/40 mutant 604162005357 Transposon insertion site of 73/6 mutant 604162005358 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 604162005359 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 604162005360 YadA-like C-terminal region; Region: YadA; pfam03895 604162005361 Transposon insertion site of 77/29 mutant 604162005362 Transposon insertion site of 65/18 mutant 604162005363 Transposon insertion site of 26/45 mutant 604162005364 Transposon insertion site of 52/12 mutant 604162005365 Transposon insertion site of 47/19 mutant 604162005366 Transposon insertion site of 75/22 mutant 604162005367 Transposase domain (DUF772); Region: DUF772; pfam05598 604162005368 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162005369 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 604162005370 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 604162005371 Transposon insertion site of 69/32 mutant 604162005372 Transposon insertion site of 60/21 mutant 604162005373 Transposon insertion site of 89/18 mutant 604162005374 Uncharacterized conserved protein [Function unknown]; Region: COG3422 604162005375 Transposon insertion site of 6/13 mutant 604162005376 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 604162005377 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 604162005378 active site 604162005379 metal binding site [ion binding]; metal-binding site 604162005380 Transposon insertion site of 56/41 mutant 604162005381 Mor transcription activator family; Region: Mor; cl02360 604162005382 Mu-like prophage protein gp16 [Function unknown]; Region: COG4382 604162005383 Transposon insertion site of 26/41 mutant 604162005384 Transposon insertion site of 12/18 mutant 604162005385 Transposon insertion site of 50/35 mutant 604162005386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 604162005387 Transposase; Region: DEDD_Tnp_IS110; pfam01548 604162005388 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 604162005389 Transposon insertion site of 53/7 mutant 604162005390 Transposon insertion site of 9/2 mutant 604162005391 Transposon insertion site of 76/1 mutant 604162005392 Transposon insertion site of 56/15 mutant 604162005393 Transposon insertion site of 81/40 mutant 604162005394 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 604162005395 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 604162005396 purine monophosphate binding site [chemical binding]; other site 604162005397 dimer interface [polypeptide binding]; other site 604162005398 putative catalytic residues [active] 604162005399 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 604162005400 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 604162005401 Transposon insertion site of 32/14 mutant 604162005402 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 604162005403 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 604162005404 putative ion selectivity filter; other site 604162005405 putative pore gating glutamate residue; other site 604162005406 Transposon insertion site of 21/27 mutant 604162005407 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 604162005408 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 604162005409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 604162005410 motif II; other site 604162005411 Transposon insertion site of 74/20 mutant 604162005412 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 604162005413 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 604162005414 ligand binding site [chemical binding]; other site 604162005415 homodimer interface [polypeptide binding]; other site 604162005416 NAD(P) binding site [chemical binding]; other site 604162005417 trimer interface B [polypeptide binding]; other site 604162005418 trimer interface A [polypeptide binding]; other site 604162005419 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 604162005420 Transposon insertion site of 84/45 mutant 604162005421 Predicted membrane protein [Function unknown]; Region: COG3686 604162005422 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 604162005423 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 604162005424 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 604162005425 Transposon insertion site of 11/45 mutant 604162005426 Transposon insertion site of 69/12 mutant 604162005427 Transposon insertion site of 88/26 mutant 604162005428 Evidence 7 : Gene remnant; PubMedId : 16769696; Product type pf : putative factor 604162005429 Transposon insertion site of 25/31 mutant 604162005430 Protein of unknown function (DUF1132); Region: DUF1132; pfam06575 604162005431 Transposon insertion site of 86/14 mutant 604162005432 Transposon insertion site of 54/38 mutant 604162005433 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16769696; Product type pe : putative enzyme' 604162005434 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16769696; Product type pe : putative enzyme' 604162005435 Evidence 7 : Gene remnant; Product type e : enzyme 604162005436 Transposon insertion site of 86/12 mutant 604162005437 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 604162005438 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 604162005439 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 604162005440 Transposon insertion site of 45/29 mutant 604162005441 Transposon insertion site of 64/2 mutant 604162005442 Transposon insertion site of 9/19 mutant 604162005443 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 604162005444 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 604162005445 glutamine binding [chemical binding]; other site 604162005446 catalytic triad [active] 604162005447 Transposon insertion site of 26/22 mutant 604162005448 Transposon insertion site of 43/24 mutant 604162005449 Transposon insertion site of 96/1 mutant 604162005450 Transposon insertion site of 85/1 mutant 604162005451 Transposon insertion site of 28/39 mutant 604162005452 Transposon insertion site of 49/11 mutant 604162005453 Transposon insertion site of 25/21 mutant 604162005454 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 604162005455 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 604162005456 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 604162005457 Transposon insertion site of 54/34 mutant 604162005458 Transposon insertion site of 67/16 mutant 604162005459 Transposon insertion site of 34/18 mutant 604162005460 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 604162005461 Transposon insertion site of 80/11 mutant 604162005462 Transposon insertion site of 67/10 mutant 604162005463 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 604162005464 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 604162005465 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 604162005466 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 604162005467 Transposon insertion site of 68/38 mutant 604162005468 YjzC-like protein; Region: YjzC; pfam14168 604162005469 Predicted transcriptional regulator [Transcription]; Region: COG2378 604162005470 WYL domain; Region: WYL; pfam13280 604162005471 Transposon insertion site of 11/41 mutant 604162005472 Transposon insertion site of 52/30 mutant 604162005473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 604162005474 Transposon insertion site of 34/5 mutant 604162005475 Transposon insertion site of 16/43 mutant 604162005476 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 604162005477 CoA binding domain; Region: CoA_binding; smart00881 604162005478 CoA-ligase; Region: Ligase_CoA; pfam00549 604162005479 Transposon insertion site of 37/25 mutant 604162005480 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 604162005481 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 604162005482 CoA-ligase; Region: Ligase_CoA; pfam00549 604162005483 Transposon insertion site of 76/3 mutant 604162005484 Transposon insertion site of 71/29 mutant 604162005485 Transposon insertion site of 13/7 mutant 604162005486 Transposon insertion site of 59/2 mutant 604162005487 Transposon insertion site of 93/18 mutant 604162005488 Transposon insertion site of 95/6 mutant 604162005489 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 604162005490 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 604162005491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 604162005492 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 604162005493 Transposon insertion site of 46/22 mutant 604162005494 Transposon insertion site of 94/31 mutant 604162005495 Transposon insertion site of 54/11 mutant 604162005496 Transposon insertion site of 50/4 mutant 604162005497 Transposon insertion site of 22/1 mutant 604162005498 Transposon insertion site of 59/27 mutant 604162005499 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 604162005500 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 604162005501 E3 interaction surface; other site 604162005502 lipoyl attachment site [posttranslational modification]; other site 604162005503 e3 binding domain; Region: E3_binding; pfam02817 604162005504 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 604162005505 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 604162005506 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 604162005507 TPP-binding site [chemical binding]; other site 604162005508 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 604162005509 Transposon insertion site of 76/41 mutant 604162005510 Transposon insertion site of 15/24 mutant 604162005511 Transposon insertion site of 21/17 mutant 604162005512 Transposon insertion site of 13/12 mutant 604162005513 Transposon insertion site of 19/42 mutant 604162005514 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 604162005515 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 604162005516 dimer interface [polypeptide binding]; other site 604162005517 active site 604162005518 citrylCoA binding site [chemical binding]; other site 604162005519 NADH binding [chemical binding]; other site 604162005520 cationic pore residues; other site 604162005521 oxalacetate/citrate binding site [chemical binding]; other site 604162005522 coenzyme A binding site [chemical binding]; other site 604162005523 catalytic triad [active] 604162005524 Transposon insertion site of 58/11 mutant 604162005525 Transposon insertion site of 81/36 mutant 604162005526 Transposon insertion site of 21/1 mutant 604162005527 Transposon insertion site of 16/6 mutant 604162005528 Uncharacterized conserved protein [Function unknown]; Region: COG2938 604162005529 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 604162005530 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 604162005531 Transposon insertion site of 22/41 mutant 604162005532 Transposon insertion site of 18/44 mutant 604162005533 succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; Region: sdhA_forward; TIGR01816 604162005534 L-aspartate oxidase; Provisional; Region: PRK06175 604162005535 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 604162005536 Transposon insertion site of 64/18 mutant 604162005537 Transposon insertion site of 61/10 mutant 604162005538 Transposon insertion site of 27/31 mutant 604162005539 Transposon insertion site of 35/47 mutant 604162005540 Transposon insertion site of 27/18 mutant 604162005541 Transposon insertion site of 23/3 mutant 604162005542 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 604162005543 SdhC subunit interface [polypeptide binding]; other site 604162005544 proximal heme binding site [chemical binding]; other site 604162005545 cardiolipin binding site; other site 604162005546 Iron-sulfur protein interface; other site 604162005547 proximal quinone binding site [chemical binding]; other site 604162005548 Transposon insertion site of 51/23 mutant 604162005549 Transposon insertion site of 86/23 mutant 604162005550 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 604162005551 Iron-sulfur protein interface; other site 604162005552 proximal quinone binding site [chemical binding]; other site 604162005553 SdhD (CybS) interface [polypeptide binding]; other site 604162005554 proximal heme binding site [chemical binding]; other site 604162005555 Transposon insertion site of 92/23 mutant 604162005556 Transposon insertion site of 43/3 mutant 604162005557 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 604162005558 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 604162005559 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 604162005560 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 604162005561 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 604162005562 catalytic triad [active] 604162005563 dimer interface [polypeptide binding]; other site 604162005564 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 604162005565 GSH binding site [chemical binding]; other site 604162005566 catalytic residues [active] 604162005567 Transposon insertion site of 84/37 mutant 604162005568 Transposon insertion site of 5/29 mutant 604162005569 Transposon insertion site of 65/23 mutant 604162005570 Transposon insertion site of 40/5 mutant 604162005571 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 604162005572 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 604162005573 THF binding site; other site 604162005574 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 604162005575 substrate binding site [chemical binding]; other site 604162005576 THF binding site; other site 604162005577 zinc-binding site [ion binding]; other site 604162005578 Transposon insertion site of 71/7 mutant 604162005579 Transposon insertion site of 48/28 mutant 604162005580 Transposon insertion site of 58/30 mutant 604162005581 Transposon insertion site of 42/38 mutant 604162005582 Transposon insertion site of 45/20 mutant 604162005583 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 604162005584 FAD binding site [chemical binding]; other site 604162005585 Transposon insertion site of 51/13 mutant 604162005586 Transposon insertion site of 69/29 mutant 604162005587 Transposon insertion site of 54/33 mutant 604162005588 Transposon insertion site of 91/19 mutant 604162005589 Transposon insertion site of 42/23 mutant 604162005590 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 604162005591 Transposon insertion site of 96/2 mutant 604162005592 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 604162005593 Transposon insertion site of 29/22 mutant 604162005594 Transposon insertion site of 15/11 mutant 604162005595 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 604162005596 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 604162005597 Transposon insertion site of 3/11 mutant 604162005598 Transposon insertion site of 14/42 mutant 604162005599 Transposon insertion site of 69/4 mutant 604162005600 Methyltransferase domain; Region: Methyltransf_23; pfam13489 604162005601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162005602 S-adenosylmethionine binding site [chemical binding]; other site 604162005603 Transposon insertion site of 69/3 mutant 604162005604 Transposon insertion site of 85/43 mutant 604162005605 Transposon insertion site of 11/25 mutant 604162005606 elongation factor P; Validated; Region: PRK00529 604162005607 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 604162005608 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 604162005609 RNA binding site [nucleotide binding]; other site 604162005610 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 604162005611 RNA binding site [nucleotide binding]; other site 604162005612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 604162005613 conserved hypothetical protein, PP_1857 family; Region: efp_adjacent_2; TIGR03837 604162005614 Transposon insertion site of 94/26 mutant 604162005615 Transposon insertion site of 37/45 mutant 604162005616 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 604162005617 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 604162005618 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 604162005619 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 604162005620 nucleoside/Zn binding site; other site 604162005621 dimer interface [polypeptide binding]; other site 604162005622 catalytic motif [active] 604162005623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 604162005624 Transposon insertion site of 59/12 mutant 604162005625 Transposon insertion site of 70/42 mutant 604162005626 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 604162005627 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 604162005628 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 604162005629 xanthine permease; Region: pbuX; TIGR03173 604162005630 Transposon insertion site of 46/38 mutant 604162005631 Transposon insertion site of 45/36 mutant 604162005632 Transposon insertion site of 14/28 mutant 604162005633 Transposon insertion site of 68/15 mutant 604162005634 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 604162005635 dihydrodipicolinate synthase; Region: dapA; TIGR00674 604162005636 dimer interface [polypeptide binding]; other site 604162005637 active site 604162005638 catalytic residue [active] 604162005639 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 604162005640 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 604162005641 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 604162005642 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type m : membrane component 604162005643 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type m : membrane component 604162005644 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 604162005645 malonic semialdehyde reductase; Provisional; Region: PRK10538 604162005646 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 604162005647 putative NAD(P) binding site [chemical binding]; other site 604162005648 homotetramer interface [polypeptide binding]; other site 604162005649 homodimer interface [polypeptide binding]; other site 604162005650 active site 604162005651 Cytochrome C' Region: Cytochrom_C_2; cl01610 604162005652 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 604162005653 Transposon insertion site of 39/23 mutant 604162005654 Transposon insertion site of 9/46 mutant 604162005655 Transposon insertion site of 65/40 mutant 604162005656 Transposon insertion site of 94/8 mutant 604162005657 Transposon insertion site of 73/46 mutant 604162005658 Transposon insertion site of 16/34 mutant 604162005659 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 604162005660 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 604162005661 Transposon insertion site of 4/12 mutant 604162005662 Transposon insertion site of 74/7 mutant 604162005663 Transposon insertion site of 71/46 mutant 604162005664 Transposon insertion site of 95/11 mutant 604162005665 Transposon insertion site of 89/27 mutant 604162005666 Transposon insertion site of 66/15 mutant 604162005667 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 604162005668 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 604162005669 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 604162005670 Transposon insertion site of 28/2 mutant 604162005671 Transposon insertion site of 50/44 mutant 604162005672 Transposon insertion site of 52/35 mutant 604162005673 Peptidase M15; Region: Peptidase_M15_3; cl01194 604162005674 Transposon insertion site of 83/10 mutant 604162005675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 604162005676 Transposon insertion site of 51/38 mutant 604162005677 Transposon insertion site of 58/38 mutant 604162005678 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 604162005679 Transposon insertion site of 51/47 mutant 604162005680 Transposon insertion site of 37/32 mutant 604162005681 Transposon insertion site of 82/3 mutant 604162005682 Transposon insertion site of 74/21 mutant 604162005683 Transposon insertion site of 39/29 mutant 604162005684 Transposon insertion site of 82/30 mutant 604162005685 Transposon insertion site of 28/7 mutant 604162005686 Transposon insertion site of 28/15 mutant 604162005687 Transposon insertion site of 82/5 mutant 604162005688 Transposon insertion site of 18/8 mutant 604162005689 Transposon insertion site of 2/21 mutant 604162005690 Transposon insertion site of 17/3 mutant 604162005691 Transposon insertion site of 50/37 mutant 604162005692 Transposon insertion site of 91/11 mutant 604162005693 Transposon insertion site of 51/6 mutant 604162005694 Transposon insertion site of 33/8 mutant 604162005695 Transposon insertion site of 51/24 mutant 604162005696 Transposon insertion site of 4/31 mutant 604162005697 Transposon insertion site of 46/29 mutant 604162005698 Transposon insertion site of 89/36 mutant 604162005699 Transposon insertion site of 34/36 mutant 604162005700 Transposon insertion site of 7/4 mutant 604162005701 Transposon insertion site of 11/21 mutant 604162005702 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 604162005703 integrase; Provisional; Region: PRK09692 604162005704 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 604162005705 active site 604162005706 Int/Topo IB signature motif; other site 604162005707 Transposon insertion site of 43/15 mutant 604162005708 Transposon insertion site of 94/14 mutant 604162005709 Transposon insertion site of 16/22 mutant 604162005710 Transposon insertion site of 78/18 mutant 604162005711 Transposon insertion site of 59/6 mutant 604162005712 hypothetical protein; Validated; Region: PRK02101 604162005713 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 604162005714 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 604162005715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162005716 homodimer interface [polypeptide binding]; other site 604162005717 catalytic residue [active] 604162005718 Transposon insertion site of 95/3 mutant 604162005719 Transposon insertion site of 40/25 mutant 604162005720 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 604162005721 trimer interface [polypeptide binding]; other site 604162005722 active site 604162005723 Evidence 7 : Gene remnant 604162005724 Transposon insertion site of 18/19 mutant 604162005725 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 604162005726 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 604162005727 Minor type IV pilin, PilX; Region: Pilin_PilX; pfam11530 604162005728 Transposon insertion site of 12/39 mutant 604162005729 Transposon insertion site of 41/23 mutant 604162005730 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 604162005731 PilX N-terminal; Region: PilX_N; pfam14341 604162005732 Transposon insertion site of 75/27 mutant 604162005733 Transposon insertion site of 64/44 mutant 604162005734 Transposon insertion site of 22/16 mutant 604162005735 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 604162005736 Transposon insertion site of 22/9 mutant 604162005737 Transposon insertion site of 34/7 mutant 604162005738 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 604162005739 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 604162005740 Transposon insertion site of 49/35 mutant 604162005741 Transposon insertion site of 59/35 mutant 604162005742 Transposon insertion site of 50/25 mutant 604162005743 Transposon insertion site of 30/18 mutant 604162005744 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 604162005745 Type II transport protein GspH; Region: GspH; pfam12019 604162005746 Transposon insertion site of 78/46 mutant 604162005747 replicative DNA helicase; Region: DnaB; TIGR00665 604162005748 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 604162005749 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 604162005750 Walker A motif; other site 604162005751 ATP binding site [chemical binding]; other site 604162005752 Walker B motif; other site 604162005753 DNA binding loops [nucleotide binding] 604162005754 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 604162005755 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 604162005756 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 604162005757 Transposon insertion site of 33/15 mutant 604162005758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 604162005759 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 604162005760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 604162005761 dimer interface [polypeptide binding]; other site 604162005762 conserved gate region; other site 604162005763 putative PBP binding loops; other site 604162005764 ABC-ATPase subunit interface; other site 604162005765 Transposon insertion site of 77/46 mutant 604162005766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 604162005767 dimer interface [polypeptide binding]; other site 604162005768 conserved gate region; other site 604162005769 putative PBP binding loops; other site 604162005770 ABC-ATPase subunit interface; other site 604162005771 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 604162005772 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 604162005773 Walker A/P-loop; other site 604162005774 ATP binding site [chemical binding]; other site 604162005775 Q-loop/lid; other site 604162005776 ABC transporter signature motif; other site 604162005777 Walker B; other site 604162005778 D-loop; other site 604162005779 H-loop/switch region; other site 604162005780 Transposon insertion site of 41/7 mutant 604162005781 threonine dehydratase; Reviewed; Region: PRK09224 604162005782 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 604162005783 tetramer interface [polypeptide binding]; other site 604162005784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162005785 catalytic residue [active] 604162005786 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 604162005787 putative Ile/Val binding site [chemical binding]; other site 604162005788 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 604162005789 putative Ile/Val binding site [chemical binding]; other site 604162005790 Transposon insertion site of 55/33 mutant 604162005791 Transposon insertion site of 33/42 mutant 604162005792 Transposon insertion site of 93/48 mutant 604162005793 Transposon insertion site of 29/43 mutant 604162005794 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 604162005795 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 604162005796 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 604162005797 Transposon insertion site of 40/34 mutant 604162005798 Transposon insertion site of 54/25 mutant 604162005799 Transposon insertion site of 43/21 mutant 604162005800 Transposon insertion site of 35/34 mutant 604162005801 Transposon insertion site of 17/25 mutant 604162005802 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 604162005803 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 604162005804 5S rRNA interface [nucleotide binding]; other site 604162005805 CTC domain interface [polypeptide binding]; other site 604162005806 L16 interface [polypeptide binding]; other site 604162005807 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 604162005808 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 604162005809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 604162005810 active site 604162005811 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 604162005812 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 604162005813 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 604162005814 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 604162005815 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 604162005816 Transposon insertion site of 66/9 mutant 604162005817 TPR repeat; Region: TPR_11; pfam13414 604162005818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 604162005819 binding surface 604162005820 TPR motif; other site 604162005821 Transposon insertion site of 19/12 mutant 604162005822 Transposon insertion site of 7/27 mutant 604162005823 Transposon insertion site of 72/7 mutant 604162005824 Transposon insertion site of 43/47 mutant 604162005825 pantoate--beta-alanine ligase; Region: panC; TIGR00018 604162005826 Pantoate-beta-alanine ligase; Region: PanC; cd00560 604162005827 active site 604162005828 ATP-binding site [chemical binding]; other site 604162005829 pantoate-binding site; other site 604162005830 HXXH motif; other site 604162005831 Transposon insertion site of 10/17 mutant 604162005832 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 604162005833 oligomerization interface [polypeptide binding]; other site 604162005834 active site 604162005835 metal binding site [ion binding]; metal-binding site 604162005836 Transposon insertion site of 89/43 mutant 604162005837 Transposon insertion site of 81/34 mutant 604162005838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162005839 S-adenosylmethionine binding site [chemical binding]; other site 604162005840 Transposon insertion site of 54/41 mutant 604162005841 Transposon insertion site of 87/6 mutant 604162005842 Transposon insertion site of 4/29 mutant 604162005843 Transposon insertion site of 96/43 mutant 604162005844 Transposon insertion site of 2/10 mutant 604162005845 Transposon insertion site of 49/5 mutant 604162005846 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 604162005847 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 604162005848 Transposon insertion site of 21/36 mutant 604162005849 Transposon insertion site of 13/9 mutant 604162005850 Transposon insertion site of 7/35 mutant 604162005851 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 604162005852 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 604162005853 probable active site [active] 604162005854 Transposon insertion site of 82/12 mutant 604162005855 Transposon insertion site of 48/19 mutant 604162005856 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 604162005857 Transposon insertion site of 44/6 mutant 604162005858 Transposon insertion site of 15/26 mutant 604162005859 Transposon insertion site of 13/45 mutant 604162005860 Transposon insertion site of 62/11 mutant 604162005861 Transposon insertion site of 40/12 mutant 604162005862 Transposon insertion site of 47/27 mutant 604162005863 Transposon insertion site of 85/16 mutant 604162005864 Transposon insertion site of 20/42 mutant 604162005865 Transposon insertion site of 10/16 mutant 604162005866 Transposon insertion site of 83/7 mutant 604162005867 Transposon insertion site of 11/13 mutant 604162005868 Transposon insertion site of 79/47 mutant 604162005869 Transposon insertion site of 66/8 mutant 604162005870 Transposon insertion site of 93/8 mutant 604162005871 Transposon insertion site of 27/29 mutant 604162005872 Transposon insertion site of 51/48 mutant 604162005873 Transposon insertion site of 89/8 mutant 604162005874 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 604162005875 putative active site [active] 604162005876 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 604162005877 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 604162005878 dimer interface [polypeptide binding]; other site 604162005879 motif 1; other site 604162005880 active site 604162005881 motif 2; other site 604162005882 motif 3; other site 604162005883 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 604162005884 anticodon binding site; other site 604162005885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 604162005886 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 604162005887 Transposon insertion site of 90/12 mutant 604162005888 GTP-binding protein Der; Reviewed; Region: PRK00093 604162005889 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 604162005890 G1 box; other site 604162005891 GTP/Mg2+ binding site [chemical binding]; other site 604162005892 Switch I region; other site 604162005893 G2 box; other site 604162005894 Switch II region; other site 604162005895 G3 box; other site 604162005896 G4 box; other site 604162005897 G5 box; other site 604162005898 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 604162005899 G1 box; other site 604162005900 GTP/Mg2+ binding site [chemical binding]; other site 604162005901 Switch I region; other site 604162005902 G2 box; other site 604162005903 G3 box; other site 604162005904 Switch II region; other site 604162005905 G4 box; other site 604162005906 G5 box; other site 604162005907 Putative exonuclease, RdgC; Region: RdgC; cl01122 604162005908 Transposon insertion site of 22/7 mutant 604162005909 Transposon insertion site of 84/13 mutant 604162005910 Transposon insertion site of 2/39 mutant 604162005911 Transposon insertion site of 46/31 mutant 604162005912 Evidence 5 : No homology to any previously reported sequences 604162005913 Transposon insertion site of 63/45 mutant 604162005914 Evidence 5 : No homology to any previously reported sequences 604162005915 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 604162005916 trimer interface [polypeptide binding]; other site 604162005917 active site 604162005918 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3471 604162005919 Transposon insertion site of 24/8 mutant 604162005920 Transposon insertion site of 75/18 mutant 604162005921 Transposon insertion site of 41/26 mutant 604162005922 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162005923 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162005924 Transposon insertion site of 45/30 mutant 604162005925 Transposon insertion site of 79/41 mutant 604162005926 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162005927 Transposon insertion site of 41/24 mutant 604162005928 Transposon insertion site of 33/27 mutant 604162005929 Transposon insertion site of 96/41 mutant 604162005930 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 604162005931 PhoH-like protein; Region: PhoH; pfam02562 604162005932 Transposon insertion site of 5/1 mutant 604162005933 Transposon insertion site of 42/33 mutant 604162005934 Transposon insertion site of 78/12 mutant 604162005935 Protein of unknown function (DUF3247); Region: DUF3247; pfam11607 604162005936 Transposon insertion site of 31/33 mutant 604162005937 Transposon insertion site of 70/31 mutant 604162005938 Transposon insertion site of 70/15 mutant 604162005939 poly(A) polymerase; Region: pcnB; TIGR01942 604162005940 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 604162005941 active site 604162005942 NTP binding site [chemical binding]; other site 604162005943 metal binding triad [ion binding]; metal-binding site 604162005944 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 604162005945 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 604162005946 Transposon insertion site of 6/18 mutant 604162005947 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 604162005948 DHH family; Region: DHH; pfam01368 604162005949 DHHA1 domain; Region: DHHA1; pfam02272 604162005950 Transposon insertion site of 43/9 mutant 604162005951 Transposon insertion site of 25/46 mutant 604162005952 Transposon insertion site of 60/2 mutant 604162005953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 604162005954 Transposon insertion site of 25/2 mutant 604162005955 peptidase PmbA; Provisional; Region: PRK11040 604162005956 Transposon insertion site of 18/3 mutant 604162005957 Transposon insertion site of 15/46 mutant 604162005958 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 604162005959 DNA-binding site [nucleotide binding]; DNA binding site 604162005960 RNA-binding motif; other site 604162005961 Uncharacterized conserved protein [Function unknown]; Region: COG2127 604162005962 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 604162005963 Clp amino terminal domain; Region: Clp_N; pfam02861 604162005964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162005965 Walker A motif; other site 604162005966 ATP binding site [chemical binding]; other site 604162005967 Walker B motif; other site 604162005968 arginine finger; other site 604162005969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162005970 Walker A motif; other site 604162005971 ATP binding site [chemical binding]; other site 604162005972 Walker B motif; other site 604162005973 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 604162005974 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 604162005975 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 604162005976 NADP binding site [chemical binding]; other site 604162005977 homopentamer interface [polypeptide binding]; other site 604162005978 substrate binding site [chemical binding]; other site 604162005979 active site 604162005980 Transposon insertion site of 7/30 mutant 604162005981 Transposon insertion site of 47/39 mutant 604162005982 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 604162005983 HNH endonuclease; Region: HNH_2; pfam13391 604162005984 Transposon insertion site of 54/9 mutant 604162005985 Transposon insertion site of 21/44 mutant 604162005986 Transposon insertion site of 45/40 mutant 604162005987 Transposon insertion site of 1/45 mutant 604162005988 Transposon insertion site of 63/43 mutant 604162005989 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 604162005990 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 604162005991 cofactor binding site; other site 604162005992 DNA binding site [nucleotide binding] 604162005993 substrate interaction site [chemical binding]; other site 604162005994 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 604162005995 Transposon insertion site of 1/7 mutant 604162005996 Transposon insertion site of 31/44 mutant 604162005997 Transposon insertion site of 60/25 mutant 604162005998 Transposon insertion site of 93/11 mutant 604162005999 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 604162006000 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 604162006001 putative ribose interaction site [chemical binding]; other site 604162006002 putative ADP binding site [chemical binding]; other site 604162006003 Transposon insertion site of 13/6 mutant 604162006004 Transposon insertion site of 76/8 mutant 604162006005 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 604162006006 active site 604162006007 dimer interface [polypeptide binding]; other site 604162006008 Transposon insertion site of 72/44 mutant 604162006009 Transposon insertion site of 69/48 mutant 604162006010 adenylate kinase; Reviewed; Region: adk; PRK00279 604162006011 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 604162006012 AMP-binding site [chemical binding]; other site 604162006013 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 604162006014 heat shock protein HtpX; Provisional; Region: PRK05457 604162006015 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 604162006016 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 604162006017 GDP-binding site [chemical binding]; other site 604162006018 ACT binding site; other site 604162006019 IMP binding site; other site 604162006020 ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705 604162006021 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 604162006022 dimer interface [polypeptide binding]; other site 604162006023 motif 1; other site 604162006024 active site 604162006025 motif 2; other site 604162006026 motif 3; other site 604162006027 Transposon insertion site of 39/8 mutant 604162006028 Transposon insertion site of 32/39 mutant 604162006029 Transposon insertion site of 66/30 mutant 604162006030 Transposon insertion site of 61/36 mutant 604162006031 Transposon insertion site of 57/33 mutant 604162006032 Transposon insertion site of 37/27 mutant 604162006033 multidrug efflux protein; Reviewed; Region: PRK01766 604162006034 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 604162006035 cation binding site [ion binding]; other site 604162006036 Transposon insertion site of 82/48 mutant 604162006037 Transposon insertion site of 61/18 mutant 604162006038 Transposon insertion site of 83/11 mutant 604162006039 Transposon insertion site of 8/22 mutant 604162006040 Transposon insertion site of 69/7 mutant 604162006041 Transposon insertion site of 87/35 mutant 604162006042 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 604162006043 FAD binding domain; Region: FAD_binding_4; pfam01565 604162006044 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 604162006045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 604162006046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 604162006047 Bacterial transcriptional repressor; Region: TetR; pfam13972 604162006048 Transposon insertion site of 28/41 mutant 604162006049 Transposon insertion site of 77/33 mutant 604162006050 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 604162006051 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 604162006052 putative NAD(P) binding site [chemical binding]; other site 604162006053 Transposon insertion site of 48/30 mutant 604162006054 Transposon insertion site of 37/37 mutant 604162006055 Transposon insertion site of 32/43 mutant 604162006056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 604162006057 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04539 604162006058 ATP-NAD kinase; Region: NAD_kinase; pfam01513 604162006059 Transposon insertion site of 93/44 mutant 604162006060 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 604162006061 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 604162006062 RNA binding surface [nucleotide binding]; other site 604162006063 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 604162006064 active site 604162006065 Transposon insertion site of 68/45 mutant 604162006066 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 604162006067 dimer interface [polypeptide binding]; other site 604162006068 FMN binding site [chemical binding]; other site 604162006069 Transposon insertion site of 25/14 mutant 604162006070 Transposon insertion site of 29/32 mutant 604162006071 putative GTP cyclohydrolase; Provisional; Region: PRK13674 604162006072 Transposon insertion site of 20/41 mutant 604162006073 Transposon insertion site of 81/3 mutant 604162006074 Transposon insertion site of 38/35 mutant 604162006075 Transposon insertion site of 24/18 mutant 604162006076 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 604162006077 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 604162006078 homodimer interface [polypeptide binding]; other site 604162006079 substrate-cofactor binding pocket; other site 604162006080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162006081 catalytic residue [active] 604162006082 Transposon insertion site of 68/16 mutant 604162006083 Transposon insertion site of 6/28 mutant 604162006084 Transposon insertion site of 92/4 mutant 604162006085 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 604162006086 dimer interface [polypeptide binding]; other site 604162006087 active site 604162006088 aspartate-rich active site metal binding site; other site 604162006089 allosteric magnesium binding site [ion binding]; other site 604162006090 Schiff base residues; other site 604162006091 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 604162006092 Transposon insertion site of 15/1 mutant 604162006093 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 604162006094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162006095 S-adenosylmethionine binding site [chemical binding]; other site 604162006096 Transposon insertion site of 80/14 mutant 604162006097 Transposon insertion site of 29/7 mutant 604162006098 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 604162006099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162006100 Walker A motif; other site 604162006101 ATP binding site [chemical binding]; other site 604162006102 Walker B motif; other site 604162006103 arginine finger; other site 604162006104 Peptidase family M41; Region: Peptidase_M41; pfam01434 604162006105 Transposon insertion site of 53/11 mutant 604162006106 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 604162006107 putative coenzyme Q binding site [chemical binding]; other site 604162006108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 604162006109 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 604162006110 putative active site [active] 604162006111 catalytic residue [active] 604162006112 VanZ like family; Region: VanZ; cl01971 604162006113 Transposon insertion site of 26/40 mutant 604162006114 Transposon insertion site of 69/20 mutant 604162006115 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 604162006116 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 604162006117 Transposon insertion site of 29/42 mutant 604162006118 Transposon insertion site of 61/27 mutant 604162006119 Transposon insertion site of 48/44 mutant 604162006120 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 604162006121 active site 604162006122 Transposon insertion site of 94/18 mutant 604162006123 Transposon insertion site of 64/30 mutant 604162006124 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 604162006125 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 604162006126 active site 604162006127 substrate binding site [chemical binding]; other site 604162006128 metal binding site [ion binding]; metal-binding site 604162006129 Transposon insertion site of 94/2 mutant 604162006130 Transposon insertion site of 25/5 mutant 604162006131 Transposon insertion site of 2/46 mutant 604162006132 Transposon insertion site of 92/48 mutant 604162006133 Transposon insertion site of 6/35 mutant 604162006134 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 604162006135 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 604162006136 Walker A/P-loop; other site 604162006137 ATP binding site [chemical binding]; other site 604162006138 Q-loop/lid; other site 604162006139 ABC transporter signature motif; other site 604162006140 Walker B; other site 604162006141 D-loop; other site 604162006142 H-loop/switch region; other site 604162006143 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 604162006144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 604162006145 dimer interface [polypeptide binding]; other site 604162006146 conserved gate region; other site 604162006147 putative PBP binding loops; other site 604162006148 ABC-ATPase subunit interface; other site 604162006149 Transposon insertion site of 17/2 mutant 604162006150 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 604162006151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 604162006152 substrate binding pocket [chemical binding]; other site 604162006153 membrane-bound complex binding site; other site 604162006154 hinge residues; other site 604162006155 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 604162006156 Transposon insertion site of 23/21 mutant 604162006157 Transposon insertion site of 40/14 mutant 604162006158 Transposon insertion site of 54/19 mutant 604162006159 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 604162006160 Part of AAA domain; Region: AAA_19; pfam13245 604162006161 Family description; Region: UvrD_C_2; pfam13538 604162006162 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 604162006163 Transposon insertion site of 9/28 mutant 604162006164 Transposon insertion site of 8/42 mutant 604162006165 Transposon insertion site of 41/35 mutant 604162006166 Transposon insertion site of 22/40 mutant 604162006167 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 604162006168 active site residue [active] 604162006169 Transposon insertion site of 16/39 mutant 604162006170 Uncharacterized conserved protein [Function unknown]; Region: COG3439 604162006171 Transposon insertion site of 65/41 mutant 604162006172 Transposon insertion site of 72/33 mutant 604162006173 DNA repair protein RadA; Provisional; Region: PRK11823 604162006174 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 604162006175 Walker A motif/ATP binding site; other site 604162006176 ATP binding site [chemical binding]; other site 604162006177 Walker B motif; other site 604162006178 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 604162006179 Transposon insertion site of 44/16 mutant 604162006180 Transposon insertion site of 9/5 mutant 604162006181 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 604162006182 substrate binding site [chemical binding]; other site 604162006183 active site 604162006184 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 604162006185 Transposon insertion site of 51/1 mutant 604162006186 Transposon insertion site of 49/1 mutant 604162006187 Transposon insertion site of 80/2 mutant 604162006188 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 604162006189 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 604162006190 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 604162006191 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 604162006192 active site 604162006193 Transposon insertion site of 64/5 mutant 604162006194 Transposon insertion site of 91/6 mutant 604162006195 Transposon insertion site of 22/3 mutant 604162006196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4390 604162006197 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 604162006198 active site 604162006199 Transposon insertion site of 17/37 mutant 604162006200 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 604162006201 putative GSH binding site [chemical binding]; other site 604162006202 catalytic residues [active] 604162006203 Transposon insertion site of 54/46 mutant 604162006204 Transposon insertion site of 5/8 mutant 604162006205 Transposon insertion site of 14/36 mutant 604162006206 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 604162006207 active site 604162006208 Transposon insertion site of 1/24 mutant 604162006209 Transposon insertion site of 7/33 mutant 604162006210 Transposon insertion site of 30/5 mutant 604162006211 Tfp pilus assembly protein PilZ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilZ; COG3215 604162006212 Transposon insertion site of 11/22 mutant 604162006213 Transposon insertion site of 981 mutant 604162006214 DNA polymerase III subunit delta'; Validated; Region: PRK08699 604162006215 DNA polymerase III subunit delta'; Validated; Region: PRK08485 604162006216 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 604162006217 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 604162006218 Walker A motif; other site 604162006219 ATP binding site [chemical binding]; other site 604162006220 Walker B motif; other site 604162006221 Transposon insertion site of 90/19 mutant 604162006222 Transposon insertion site of 49/42 mutant 604162006223 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 604162006224 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 604162006225 Transposon insertion site of 61/30 mutant 604162006226 GTP-binding protein LepA; Provisional; Region: PRK05433 604162006227 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 604162006228 G1 box; other site 604162006229 putative GEF interaction site [polypeptide binding]; other site 604162006230 GTP/Mg2+ binding site [chemical binding]; other site 604162006231 Switch I region; other site 604162006232 G2 box; other site 604162006233 G3 box; other site 604162006234 Switch II region; other site 604162006235 G4 box; other site 604162006236 G5 box; other site 604162006237 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 604162006238 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 604162006239 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 604162006240 Transposon insertion site of 50/17 mutant 604162006241 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 604162006242 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 604162006243 Catalytic site [active] 604162006244 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 604162006245 Transposon insertion site of 78/7 mutant 604162006246 EamA-like transporter family; Region: EamA; pfam00892 604162006247 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 604162006248 Transposon insertion site of 29/20 mutant 604162006249 Transposon insertion site of 42/41 mutant 604162006250 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 604162006251 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 604162006252 dimer interface [polypeptide binding]; other site 604162006253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162006254 catalytic residue [active] 604162006255 Transposon insertion site of 44/34 mutant 604162006256 Transposon insertion site of 7/40 mutant 604162006257 Transposon insertion site of 89/5 mutant 604162006258 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 604162006259 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 604162006260 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 604162006261 Transposon insertion site of 72/39 mutant 604162006262 Transposon insertion site of 45/33 mutant 604162006263 Transposon insertion site of 45/4 mutant 604162006264 Uncharacterized conserved protein [Function unknown]; Region: COG2836 604162006265 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 604162006266 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 604162006267 RNase E interface [polypeptide binding]; other site 604162006268 trimer interface [polypeptide binding]; other site 604162006269 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 604162006270 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 604162006271 RNase E interface [polypeptide binding]; other site 604162006272 trimer interface [polypeptide binding]; other site 604162006273 active site 604162006274 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 604162006275 putative nucleic acid binding region [nucleotide binding]; other site 604162006276 G-X-X-G motif; other site 604162006277 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 604162006278 RNA binding site [nucleotide binding]; other site 604162006279 domain interface; other site 604162006280 Transposon insertion site of 8/31 mutant 604162006281 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 604162006282 ATP binding site [chemical binding]; other site 604162006283 active site 604162006284 substrate binding site [chemical binding]; other site 604162006285 Transposon insertion site of 51/4 mutant 604162006286 Transposon insertion site of 5/15 mutant 604162006287 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 604162006288 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 604162006289 NADP binding site [chemical binding]; other site 604162006290 active site 604162006291 putative substrate binding site [chemical binding]; other site 604162006292 Transposon insertion site of 20/18 mutant 604162006293 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 604162006294 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 604162006295 Transposon insertion site of 57/38 mutant 604162006296 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 604162006297 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 604162006298 active site 604162006299 Int/Topo IB signature motif; other site 604162006300 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 604162006301 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 604162006302 catalytic triad [active] 604162006303 Transposon insertion site of 35/41 mutant 604162006304 Transposon insertion site of 77/20 mutant 604162006305 Transposon insertion site of 16/31 mutant 604162006306 Transposon insertion site of 82/40 mutant 604162006307 Transposon insertion site of 31/19 mutant 604162006308 Transposon insertion site of 31/37 mutant 604162006309 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 604162006310 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 604162006311 Transposon insertion site of 28/34 mutant 604162006312 Transposon insertion site of 23/16 mutant 604162006313 Transposon insertion site of 96/16 mutant 604162006314 Transposon insertion site of 56/18 mutant 604162006315 Transposon insertion site of 1/48 mutant 604162006316 Transposon insertion site of 46/1 mutant 604162006317 bacterial Hfq-like; Region: Hfq; cd01716 604162006318 hexamer interface [polypeptide binding]; other site 604162006319 Sm1 motif; other site 604162006320 RNA binding site [nucleotide binding]; other site 604162006321 Sm2 motif; other site 604162006322 Transposon insertion site of 68/6 mutant 604162006323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162006324 S-adenosylmethionine binding site [chemical binding]; other site 604162006325 Transposon insertion site of 39/36 mutant 604162006326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094 604162006327 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 604162006328 catalytic center binding site [active] 604162006329 ATP binding site [chemical binding]; other site 604162006330 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 604162006331 Transposon insertion site of 66/3 mutant 604162006332 Transposon insertion site of 55/28 mutant 604162006333 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 604162006334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162006335 S-adenosylmethionine binding site [chemical binding]; other site 604162006336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 604162006337 Transposon insertion site of 5/7 mutant 604162006338 Transposon insertion site of 26/4 mutant 604162006339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 604162006340 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 604162006341 Transposon insertion site of 40/32 mutant 604162006342 Transposon insertion site of 82/45 mutant 604162006343 Transposase domain (DUF772); Region: DUF772; pfam05598 604162006344 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162006345 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 604162006346 Transposon insertion site of 38/43 mutant 604162006347 Transposon insertion site of 43/43 mutant 604162006348 Transposon insertion site of 86/3 mutant 604162006349 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 604162006350 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 604162006351 Walker A/P-loop; other site 604162006352 ATP binding site [chemical binding]; other site 604162006353 Q-loop/lid; other site 604162006354 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 604162006355 ABC transporter signature motif; other site 604162006356 Walker B; other site 604162006357 D-loop; other site 604162006358 H-loop/switch region; other site 604162006359 Transposon insertion site of 68/11 mutant 604162006360 Transposon insertion site of 75/35 mutant 604162006361 Transposon insertion site of 57/41 mutant 604162006362 Transposon insertion site of 75/21 mutant 604162006363 Transposon insertion site of 45/3 mutant 604162006364 Transposon insertion site of 68/12 mutant 604162006365 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 604162006366 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 604162006367 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 604162006368 GTP/Mg2+ binding site [chemical binding]; other site 604162006369 G4 box; other site 604162006370 G5 box; other site 604162006371 G1 box; other site 604162006372 Switch I region; other site 604162006373 G2 box; other site 604162006374 G3 box; other site 604162006375 Switch II region; other site 604162006376 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 604162006377 AAA domain; Region: AAA_33; pfam13671 604162006378 Transposon insertion site of 53/33 mutant 604162006379 Transposon insertion site of 32/25 mutant 604162006380 HPr kinase/phosphorylase; Provisional; Region: PRK05428 604162006381 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 604162006382 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 604162006383 Hpr binding site; other site 604162006384 active site 604162006385 homohexamer subunit interaction site [polypeptide binding]; other site 604162006386 Transposon insertion site of 39/42 mutant 604162006387 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 604162006388 active site 604162006389 phosphorylation site [posttranslational modification] 604162006390 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 604162006391 UbiA prenyltransferase family; Region: UbiA; pfam01040 604162006392 Transposon insertion site of 70/2 mutant 604162006393 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 604162006394 Transposon insertion site of 91/12 mutant 604162006395 Transposon insertion site of 26/42 mutant 604162006396 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 604162006397 AAA domain; Region: AAA_26; pfam13500 604162006398 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 604162006399 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 604162006400 inhibitor-cofactor binding pocket; inhibition site 604162006401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162006402 catalytic residue [active] 604162006403 Transposon insertion site of 33/2 mutant 604162006404 Transposon insertion site of 73/42 mutant 604162006405 Transposon insertion site of 25/3 mutant 604162006406 Transposon insertion site of 38/48 mutant 604162006407 Transposon insertion site of 6/6 mutant 604162006408 Transposon insertion site of 84/6 mutant 604162006409 Transposon insertion site of 2/45 mutant 604162006410 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 604162006411 Transposon insertion site of 88/17 mutant 604162006412 Transposon insertion site of 86/39 mutant 604162006413 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 604162006414 IHF - DNA interface [nucleotide binding]; other site 604162006415 IHF dimer interface [polypeptide binding]; other site 604162006416 Transposon insertion site of 89/39 mutant 604162006417 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 604162006418 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 604162006419 putative tRNA-binding site [nucleotide binding]; other site 604162006420 B3/4 domain; Region: B3_4; pfam03483 604162006421 tRNA synthetase B5 domain; Region: B5; smart00874 604162006422 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 604162006423 dimer interface [polypeptide binding]; other site 604162006424 motif 1; other site 604162006425 motif 3; other site 604162006426 motif 2; other site 604162006427 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 604162006428 Transposon insertion site of 31/17 mutant 604162006429 AAA domain; Region: AAA_21; pfam13304 604162006430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 604162006431 Walker B; other site 604162006432 D-loop; other site 604162006433 H-loop/switch region; other site 604162006434 Transposon insertion site of 57/35 mutant 604162006435 Transposon insertion site of 75/44 mutant 604162006436 Transposon insertion site of 4/28 mutant 604162006437 Transposon insertion site of 79/33 mutant 604162006438 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 604162006439 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 604162006440 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 604162006441 dimer interface [polypeptide binding]; other site 604162006442 motif 1; other site 604162006443 active site 604162006444 motif 2; other site 604162006445 motif 3; other site 604162006446 Transposon insertion site of 51/17 mutant 604162006447 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 604162006448 23S rRNA binding site [nucleotide binding]; other site 604162006449 L21 binding site [polypeptide binding]; other site 604162006450 L13 binding site [polypeptide binding]; other site 604162006451 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 604162006452 translation initiation factor IF-3; Region: infC; TIGR00168 604162006453 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 604162006454 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 604162006455 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 604162006456 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 604162006457 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 604162006458 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 604162006459 active site 604162006460 dimer interface [polypeptide binding]; other site 604162006461 motif 1; other site 604162006462 motif 2; other site 604162006463 motif 3; other site 604162006464 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 604162006465 anticodon binding site; other site 604162006466 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 604162006467 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 604162006468 Transposon insertion site of 95/9 mutant 604162006469 ferrochelatase; Reviewed; Region: hemH; PRK00035 604162006470 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 604162006471 C-terminal domain interface [polypeptide binding]; other site 604162006472 active site 604162006473 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 604162006474 active site 604162006475 N-terminal domain interface [polypeptide binding]; other site 604162006476 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 604162006477 Cytochrome c; Region: Cytochrom_C; pfam00034 604162006478 Transposon insertion site of 15/38 mutant 604162006479 Evidence 7 : Gene remnant; Product type t : transporter 604162006480 Transposon insertion site of 20/39 mutant 604162006481 Transposon insertion site of 46/13 mutant 604162006482 Transposon insertion site of 67/13 mutant 604162006483 Evidence 7 : Gene remnant; Product type t : transporter 604162006484 Transposon insertion site of 55/15 mutant 604162006485 Transposon insertion site of 24/34 mutant 604162006486 Evidence 4 : Homologs of previously reported genes of unknown function 604162006487 Evidence 4 : Homologs of previously reported genes of unknown function 604162006488 Transposon insertion site of 33/46 mutant 604162006489 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 604162006490 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 604162006491 putative active site [active] 604162006492 catalytic triad [active] 604162006493 putative dimer interface [polypeptide binding]; other site 604162006494 Transposon insertion site of 50/7 mutant 604162006495 Transposon insertion site of 86/33 mutant 604162006496 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 604162006497 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 604162006498 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 604162006499 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 604162006500 DNA binding residues [nucleotide binding] 604162006501 Transposon insertion site of 7/41 and 9/43 mutants 604162006502 Transposon insertion site of 23/22 mutant 604162006503 hypothetical protein; Provisional; Region: PRK11820 604162006504 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 604162006505 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 604162006506 Transposon insertion site of 32/35 mutant 604162006507 Predicted membrane protein/domain [Function unknown]; Region: COG1714 604162006508 Transposon insertion site of 3/37 mutant 604162006509 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 604162006510 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 604162006511 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 604162006512 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 604162006513 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 604162006514 Transposon insertion site of 80/9 mutant 604162006515 Transposon insertion site of 21/26 and 80/15 mutant 604162006516 Transposon insertion site of 62/22 mutant 604162006517 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 604162006518 Sodium Bile acid symporter family; Region: SBF; pfam01758 604162006519 Transposon insertion site of 9/22 mutant 604162006520 Transposon insertion site of 1/28 mutant 604162006521 Transposon insertion site of 83/40 mutant 604162006522 Transposon insertion site of 25/8 mutant 604162006523 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 604162006524 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 604162006525 RNA binding surface [nucleotide binding]; other site 604162006526 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 604162006527 active site 604162006528 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 604162006529 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 604162006530 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 604162006531 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 604162006532 Competence protein; Region: Competence; pfam03772 604162006533 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 604162006534 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 604162006535 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 604162006536 Autotransporter beta-domain; Region: Autotransporter; pfam03797 604162006537 Transposon insertion site of 45/10 mutant 604162006538 Transposon insertion site of 42/7 mutant 604162006539 Transposon insertion site of 12/34 mutant 604162006540 Transposon insertion site of 1/39 mutant 604162006541 Transposon insertion site of 59/40 mutant 604162006542 Transposon insertion site of 64/46 mutant 604162006543 Transposon insertion site of 7/1 mutant 604162006544 Transposon insertion site of 46/5 mutant 604162006545 Transposon insertion site of 86/28 mutant 604162006546 Transposon insertion site of 9/25 mutant 604162006547 Transposon insertion site of 34/29 mutant 604162006548 Transposon insertion site of 39/18 mutant 604162006549 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 604162006550 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 604162006551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162006552 catalytic residue [active] 604162006553 Transposon insertion site of 24/38 mutant 604162006554 Transposon insertion site of 5/41 mutant 604162006555 Transposon insertion site of 8/40 mutant 604162006556 Transposon insertion site of 27/34 mutant 604162006557 Transposon insertion site of 4/11 mutant 604162006558 Transposon insertion site of 51/33 mutant 604162006559 Transposon insertion site of 59/3 mutant 604162006560 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 604162006561 putative active site [active] 604162006562 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 604162006563 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 604162006564 Transposon insertion site of 38/14 mutant 604162006565 Transposon insertion site of 65/25 mutant 604162006566 Transposon insertion site of 37/21 mutant 604162006567 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 604162006568 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 604162006569 Walker A/P-loop; other site 604162006570 ATP binding site [chemical binding]; other site 604162006571 Q-loop/lid; other site 604162006572 ABC transporter signature motif; other site 604162006573 Walker B; other site 604162006574 D-loop; other site 604162006575 H-loop/switch region; other site 604162006576 Transposon insertion site of 12/33 mutant 604162006577 Transposon insertion site of 32/18 mutant 604162006578 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 604162006579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 604162006580 cell division protein FtsN; Region: ftsN; TIGR02223 604162006581 Sporulation related domain; Region: SPOR; pfam05036 604162006582 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 604162006583 Colicin V production protein; Region: Colicin_V; pfam02674 604162006584 Transposon insertion site of 93/31 mutant 604162006585 Transposon insertion site of 64/34 mutant 604162006586 Transposon insertion site of 40/36 mutant 604162006587 Transposon insertion site of 60/4 mutant 604162006588 amidophosphoribosyltransferase; Provisional; Region: PRK09246 604162006589 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 604162006590 active site 604162006591 tetramer interface [polypeptide binding]; other site 604162006592 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 604162006593 active site 604162006594 Transposon insertion site of 58/32 mutant 604162006595 Transposon insertion site of 71/34 mutant 604162006596 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 604162006597 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 604162006598 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 604162006599 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 604162006600 active site 604162006601 Transposon insertion site of 95/39 mutant 604162006602 Transposon insertion site of 80/7 mutant 604162006603 Transposon insertion site of 96/12 mutant 604162006604 GTPase Era; Reviewed; Region: era; PRK00089 604162006605 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 604162006606 G1 box; other site 604162006607 GTP/Mg2+ binding site [chemical binding]; other site 604162006608 Switch I region; other site 604162006609 G2 box; other site 604162006610 Switch II region; other site 604162006611 G3 box; other site 604162006612 G4 box; other site 604162006613 G5 box; other site 604162006614 KH domain; Region: KH_2; pfam07650 604162006615 ribonuclease III; Reviewed; Region: rnc; PRK00102 604162006616 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 604162006617 dimerization interface [polypeptide binding]; other site 604162006618 active site 604162006619 metal binding site [ion binding]; metal-binding site 604162006620 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 604162006621 dsRNA binding site [nucleotide binding]; other site 604162006622 Transposon insertion site of 6/47 mutant 604162006623 Transposon insertion site of 11/36 mutant 604162006624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4859 604162006625 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 604162006626 homopentamer interface [polypeptide binding]; other site 604162006627 active site 604162006628 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 604162006629 putative RNA binding site [nucleotide binding]; other site 604162006630 Transposon insertion site of 86/8 mutant 604162006631 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 604162006632 active site 604162006633 substrate binding pocket [chemical binding]; other site 604162006634 dimer interface [polypeptide binding]; other site 604162006635 Transposon insertion site of 89/9 mutant 604162006636 Transposon insertion site of 1/37 mutant 604162006637 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 604162006638 CPxP motif; other site 604162006639 Transposon insertion site of 46/14 mutant 604162006640 CNP1-like family; Region: CNP1; pfam08750 604162006641 Transposon insertion site of 49/43 mutant 604162006642 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 604162006643 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 604162006644 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 604162006645 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 604162006646 substrate binding site [chemical binding]; other site 604162006647 active site 604162006648 catalytic residues [active] 604162006649 heterodimer interface [polypeptide binding]; other site 604162006650 Transposon insertion site of 46/15 mutant 604162006651 Transposon insertion site of 65/48 mutant 604162006652 Transposon insertion site of 19/24 mutant 604162006653 Transposon insertion site of 72/28 mutant 604162006654 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 604162006655 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 604162006656 Ligand binding site; other site 604162006657 oligomer interface; other site 604162006658 Uncharacterized conserved protein [Function unknown]; Region: COG2835 604162006659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 604162006660 Transposon insertion site of 13/5 mutant 604162006661 Transposon insertion site of 82/35 mutant 604162006662 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 604162006663 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 604162006664 Transposon insertion site of 86/1 mutant 604162006665 Transposon insertion site of 93/40 mutant 604162006666 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 604162006667 Malic enzyme, N-terminal domain; Region: malic; pfam00390 604162006668 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 604162006669 putative NAD(P) binding site [chemical binding]; other site 604162006670 Transposon insertion site of 43/31 mutant 604162006671 thymidylate kinase; Validated; Region: tmk; PRK00698 604162006672 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 604162006673 TMP-binding site; other site 604162006674 ATP-binding site [chemical binding]; other site 604162006675 YceG-like family; Region: YceG; pfam02618 604162006676 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 604162006677 dimerization interface [polypeptide binding]; other site 604162006678 Transposon insertion site of 46/19 mutant 604162006679 Transposon insertion site of 83/22 mutant 604162006680 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 604162006681 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 604162006682 amidase catalytic site [active] 604162006683 Zn binding residues [ion binding]; other site 604162006684 substrate binding site [chemical binding]; other site 604162006685 Transposon insertion site of 48/6 mutant 604162006686 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 604162006687 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 604162006688 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 604162006689 nucleotide binding pocket [chemical binding]; other site 604162006690 K-X-D-G motif; other site 604162006691 catalytic site [active] 604162006692 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 604162006693 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 604162006694 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 604162006695 Dimer interface [polypeptide binding]; other site 604162006696 BRCT sequence motif; other site 604162006697 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 604162006698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 604162006699 FeS/SAM binding site; other site 604162006700 HemN C-terminal domain; Region: HemN_C; pfam06969 604162006701 Transposon insertion site of 29/31 mutant 604162006702 Transposon insertion site of 26/18 mutant 604162006703 Transposon insertion site of 15/31 mutant 604162006704 Transposon insertion site of 5/17 mutant 604162006705 Transposon insertion site of 68/47 mutant 604162006706 Opacity family porin protein; Region: Opacity; pfam02462 604162006707 Transposon insertion site of 72/27 mutant 604162006708 Transposon insertion site of 9/34 mutant 604162006709 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 604162006710 homotrimer interaction site [polypeptide binding]; other site 604162006711 putative active site [active] 604162006712 Transposon insertion site of 73/20 mutant 604162006713 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 604162006714 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 604162006715 active site 604162006716 metal binding site [ion binding]; metal-binding site 604162006717 Transposon insertion site of 25/9 mutant 604162006718 Transposon insertion site of 62/35 mutant 604162006719 Cation transport protein; Region: TrkH; cl17365 604162006720 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 604162006721 Transposon insertion site of 35/23 mutant 604162006722 Transposon insertion site of 74/17 mutant 604162006723 Transposon insertion site of 34/17 mutant 604162006724 Transposon insertion site of 78/24 mutant 604162006725 Transposon insertion site of 3/23 mutant 604162006726 Transposon insertion site of 42/21 mutant 604162006727 Transposon insertion site of 24/11 mutant 604162006728 Transposon insertion site of 12/32 mutant 604162006729 Pretoxin HINT domain; Region: PT-HINT; pfam07591 604162006730 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 604162006731 thioester formation/cholesterol transfer; other site 604162006732 protein-splicing catalytic site; other site 604162006733 Transposon insertion site of 13/29 mutant 604162006734 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 604162006735 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 604162006736 Transposon insertion site of 12/27 mutant 604162006737 Transposon insertion site of 10/8 mutant 604162006738 Transposon insertion site of 8/35 mutant 604162006739 Pretoxin HINT domain; Region: PT-HINT; pfam07591 604162006740 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 604162006741 thioester formation/cholesterol transfer; other site 604162006742 protein-splicing catalytic site; other site 604162006743 Transposon insertion site of 68/23 mutant 604162006744 Transposon insertion site of 24/21 mutant 604162006745 Evidence 4 : Homologs of previously reported genes of unknown function 604162006746 Transposon insertion site of 54/37 mutant 604162006747 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 604162006748 Transposon insertion site of 58/41 mutant 604162006749 Transposon insertion site of 8/18 mutant 604162006750 Pretoxin HINT domain; Region: PT-HINT; pfam07591 604162006751 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 604162006752 thioester formation/cholesterol transfer; other site 604162006753 protein-splicing catalytic site; other site 604162006754 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 604162006755 Transposon insertion site of 73/45 mutant 604162006756 Transposon insertion site of 12/21 mutant 604162006757 Transposon insertion site of 88/39 mutant 604162006758 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 604162006759 Transposon insertion site of 76/2 mutant 604162006760 Transposon insertion site of 78/33 mutant 604162006761 Transposon insertion site of 5/40 mutant 604162006762 Transposon insertion site of 38/39 mutant 604162006763 Transposon insertion site of 17/22 mutant 604162006764 Transposon insertion site of 49/25 mutant 604162006765 Transposon insertion site of 43/46 mutant 604162006766 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 604162006767 Transposon insertion site of 52/7 mutant 604162006768 Transposon insertion site of 52/27 mutant 604162006769 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 604162006770 Transposon insertion site of 26/3 mutant 604162006771 Transposon insertion site of 48/25 mutant 604162006772 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 604162006773 nudix motif; other site 604162006774 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 604162006775 dimer interface [polypeptide binding]; other site 604162006776 substrate binding site [chemical binding]; other site 604162006777 metal binding sites [ion binding]; metal-binding site 604162006778 Transposon insertion site of 87/38 mutant 604162006779 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 604162006780 active site 604162006781 dimerization interface [polypeptide binding]; other site 604162006782 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 604162006783 active site 604162006784 tetramer interface; other site 604162006785 Transposon insertion site of 32/37 mutant 604162006786 argininosuccinate lyase; Provisional; Region: PRK00855 604162006787 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 604162006788 active sites [active] 604162006789 tetramer interface [polypeptide binding]; other site 604162006790 Transposon insertion site of 95/5 mutant 604162006791 Transposon insertion site of 6/8 mutant 604162006792 Transposon insertion site of 69/26 mutant 604162006793 Transposon insertion site of 59/47 mutant 604162006794 Transposon insertion site of 88/45 mutant 604162006795 Transposon insertion site of 53/24 mutant 604162006796 Transposon insertion site of 65/22 mutant 604162006797 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 604162006798 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 604162006799 Transposon insertion site of 52/10 mutant 604162006800 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 604162006801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 604162006802 dimer interface [polypeptide binding]; other site 604162006803 conserved gate region; other site 604162006804 putative PBP binding loops; other site 604162006805 ABC-ATPase subunit interface; other site 604162006806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 604162006807 dimer interface [polypeptide binding]; other site 604162006808 conserved gate region; other site 604162006809 ABC-ATPase subunit interface; other site 604162006810 Transposon insertion site of 56/34 mutant 604162006811 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 604162006812 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 604162006813 Walker A/P-loop; other site 604162006814 ATP binding site [chemical binding]; other site 604162006815 Q-loop/lid; other site 604162006816 ABC transporter signature motif; other site 604162006817 Walker B; other site 604162006818 D-loop; other site 604162006819 H-loop/switch region; other site 604162006820 Transposon insertion site of 10/40 mutant 604162006821 Transposon insertion site of 43/38 mutant 604162006822 Transposon insertion site of 28/38 mutant 604162006823 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 604162006824 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 604162006825 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 604162006826 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 604162006827 putative active site [active] 604162006828 oxyanion strand; other site 604162006829 catalytic triad [active] 604162006830 Transposon insertion site of 43/42 mutant 604162006831 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 604162006832 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 604162006833 catalytic residues [active] 604162006834 Transposon insertion site of 80/46 mutant 604162006835 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 604162006836 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 604162006837 substrate binding site [chemical binding]; other site 604162006838 glutamase interaction surface [polypeptide binding]; other site 604162006839 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 604162006840 Transposon insertion site of 78/40 mutant 604162006841 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 604162006842 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 604162006843 G1 box; other site 604162006844 putative GEF interaction site [polypeptide binding]; other site 604162006845 GTP/Mg2+ binding site [chemical binding]; other site 604162006846 Switch I region; other site 604162006847 G2 box; other site 604162006848 G3 box; other site 604162006849 Switch II region; other site 604162006850 G4 box; other site 604162006851 G5 box; other site 604162006852 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 604162006853 Transposon insertion site of 56/29 mutant 604162006854 Transposon insertion site of 66/29 mutant 604162006855 Transposon insertion site of 87/37 mutant 604162006856 Transposon insertion site of 76/12 mutant 604162006857 Evidence 7 : Gene remnant; Product type f : factor 604162006858 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 604162006859 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 604162006860 trimer interface [polypeptide binding]; other site 604162006861 putative metal binding site [ion binding]; other site 604162006862 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12864863; Product type e : enzyme 604162006863 Transposon insertion site of 48/26 mutant 604162006864 Transposon insertion site of 14/29 mutant 604162006865 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12864863; Product type e : enzyme 604162006866 Transposon insertion site of 56/46 mutant 604162006867 Transposon insertion site of 74/1 mutant 604162006868 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 604162006869 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 604162006870 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 604162006871 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 604162006872 Transposon insertion site of 6/16 mutant 604162006873 Transposon insertion site of 15/25 mutant 604162006874 Transposon insertion site of 49/46 mutant 604162006875 Transposon insertion site of 45/28 mutant 604162006876 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 604162006877 dinuclear metal binding motif [ion binding]; other site 604162006878 Transposon insertion site of 70/22 mutant 604162006879 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 604162006880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 604162006881 motif II; other site 604162006882 Transposon insertion site of 44/7 mutant 604162006883 Transposon insertion site of 36/3 mutant 604162006884 Transposon insertion site of 87/43 mutant 604162006885 Transposon insertion site of 37/20 and 74/29 mutants 604162006886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 604162006887 Transposon insertion site of 20/37 mutant 604162006888 Transposon insertion site of 7/11 mutant 604162006889 Transposon insertion site of 80/42 mutant 604162006890 Transposon insertion site of 83/23 mutant 604162006891 Transposon insertion site of 53/46 mutant 604162006892 Transposon insertion site of 22/12 mutant 604162006893 phosphoenolpyruvate synthase; Validated; Region: PRK06464 604162006894 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 604162006895 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 604162006896 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 604162006897 Transposon insertion site of 47/20 mutant 604162006898 Transposon insertion site of 21/41 mutant 604162006899 Transposon insertion site of 8/47 mutant 604162006900 Transposon insertion site of 39/5 mutant 604162006901 Transposon insertion site of 3/2 mutant 604162006902 transcription termination factor Rho; Provisional; Region: rho; PRK09376 604162006903 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 604162006904 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 604162006905 RNA binding site [nucleotide binding]; other site 604162006906 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 604162006907 multimer interface [polypeptide binding]; other site 604162006908 Walker A motif; other site 604162006909 ATP binding site [chemical binding]; other site 604162006910 Walker B motif; other site 604162006911 Transposon insertion site of 71/4 mutant 604162006912 Evidence 7 : Gene remnant; Product type e : enzyme 604162006913 Transposon insertion site of 12/12 mutant 604162006914 Evidence 7 : Gene remnant; Product type e : enzyme 604162006915 Evidence 7 : Gene remnant; Product type e : enzyme 604162006916 Transposon insertion site of 88/19 mutant 604162006917 Transposon insertion site of 94/11 mutant 604162006918 Transposon insertion site of 51/15 mutant 604162006919 Transposon insertion site of 2/22 mutant 604162006920 Transposon insertion site of 50/43 mutant 604162006921 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 604162006922 Transposon insertion site of 5/30 mutant 604162006923 Transposon insertion site of 38/16 mutant 604162006924 Transposon insertion site of 39/7 mutant 604162006925 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 604162006926 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 604162006927 Transposon insertion site of 89/19 mutant 604162006928 Transposon insertion site of 96/31 mutant 604162006929 Transposon insertion site of 88/43 mutant 604162006930 Transposon insertion site of 56/6 mutant 604162006931 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 604162006932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 604162006933 dimer interface [polypeptide binding]; other site 604162006934 conserved gate region; other site 604162006935 putative PBP binding loops; other site 604162006936 ABC-ATPase subunit interface; other site 604162006937 Transposon insertion site of 11/9 mutant 604162006938 Transposon insertion site of 50/32 mutant 604162006939 Transposon insertion site of 47/28 mutant 604162006940 Transposon insertion site of 38/13 mutant 604162006941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 604162006942 dimer interface [polypeptide binding]; other site 604162006943 conserved gate region; other site 604162006944 putative PBP binding loops; other site 604162006945 ABC-ATPase subunit interface; other site 604162006946 Transposon insertion site of 9/36 mutant 604162006947 Transposon insertion site of 73/29 mutant 604162006948 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 604162006949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 604162006950 Walker A/P-loop; other site 604162006951 ATP binding site [chemical binding]; other site 604162006952 Q-loop/lid; other site 604162006953 ABC transporter signature motif; other site 604162006954 Walker B; other site 604162006955 D-loop; other site 604162006956 H-loop/switch region; other site 604162006957 TOBE domain; Region: TOBE_2; pfam08402 604162006958 Transposon insertion site of 19/8 mutant 604162006959 Transposon insertion site of 30/9 mutant 604162006960 Transposon insertion site of 60/39 mutant 604162006961 Transposon insertion site of 75/4 mutant 604162006962 Transposon insertion site of 36/1 mutant 604162006963 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 604162006964 16S/18S rRNA binding site [nucleotide binding]; other site 604162006965 S13e-L30e interaction site [polypeptide binding]; other site 604162006966 25S rRNA binding site [nucleotide binding]; other site 604162006967 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 604162006968 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 604162006969 Protein export membrane protein; Region: SecD_SecF; pfam02355 604162006970 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 604162006971 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 604162006972 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 604162006973 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 604162006974 Preprotein translocase subunit; Region: YajC; pfam02699 604162006975 Transposon insertion site of 18/9 mutant 604162006976 Transposon insertion site of 82/23 mutant 604162006977 Transposon insertion site of 79/8 mutant 604162006978 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 604162006979 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 604162006980 putative active site [active] 604162006981 Zn binding site [ion binding]; other site 604162006982 Transposon insertion site of 55/11 mutant 604162006983 Transposon insertion site of 31/40 mutant 604162006984 Transposon insertion site of 88/1 mutant 604162006985 Transposon insertion site of 65/15 mutant 604162006986 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 604162006987 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 604162006988 putative NAD(P) binding site [chemical binding]; other site 604162006989 catalytic Zn binding site [ion binding]; other site 604162006990 Transposon insertion site of 94/42 mutant 604162006991 Transposon insertion site of 76/20 mutant 604162006992 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 604162006993 metal binding site [ion binding]; metal-binding site 604162006994 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 604162006995 nucleotide binding site/active site [active] 604162006996 HIT family signature motif; other site 604162006997 catalytic residue [active] 604162006998 Transposon insertion site of 58/26 mutant 604162006999 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 604162007000 sec-independent translocase; Provisional; Region: PRK00708 604162007001 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 604162007002 Transposon insertion site of 79/35 mutant 604162007003 Transposon insertion site of 93/25 mutant 604162007004 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 604162007005 Maf-like protein; Region: Maf; pfam02545 604162007006 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 604162007007 active site 604162007008 dimer interface [polypeptide binding]; other site 604162007009 Transposon insertion site of 30/25 mutant 604162007010 Predicted membrane protein [Function unknown]; Region: COG3308 604162007011 Transposon insertion site of 12/8 mutant 604162007012 Transposon insertion site of 14/47 mutant 604162007013 Transposon insertion site of 87/45 mutant 604162007014 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 604162007015 O-Antigen ligase; Region: Wzy_C; pfam04932 604162007016 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 604162007017 Transposon insertion site of 21/8 mutant 604162007018 Transposon insertion site of 42/26 mutant 604162007019 Transposon insertion site of 69/14 mutant 604162007020 Transposon insertion site of 29/28 mutant 604162007021 Transposon insertion site of 7/10 mutant 604162007022 Transposon insertion site of 56/5 mutant 604162007023 Transposon insertion site of 52/1 mutant 604162007024 Transposon insertion site of 21/3 mutant 604162007025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 604162007026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 604162007027 active site 604162007028 phosphorylation site [posttranslational modification] 604162007029 intermolecular recognition site; other site 604162007030 dimerization interface [polypeptide binding]; other site 604162007031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 604162007032 DNA binding site [nucleotide binding] 604162007033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 604162007034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 604162007035 dimerization interface [polypeptide binding]; other site 604162007036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 604162007037 dimer interface [polypeptide binding]; other site 604162007038 phosphorylation site [posttranslational modification] 604162007039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 604162007040 ATP binding site [chemical binding]; other site 604162007041 Mg2+ binding site [ion binding]; other site 604162007042 G-X-G motif; other site 604162007043 Transposon insertion site of 46/18 mutant 604162007044 Transposon insertion site of 15/16 mutant 604162007045 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 604162007046 CoA binding domain; Region: CoA_binding_2; pfam13380 604162007047 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 604162007048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 604162007049 Coenzyme A binding pocket [chemical binding]; other site 604162007050 Transposon insertion site of 55/25 mutant 604162007051 Transposon insertion site of 92/2 mutant 604162007052 Transposon insertion site of 29/29 mutant 604162007053 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 604162007054 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 604162007055 RimM N-terminal domain; Region: RimM; pfam01782 604162007056 PRC-barrel domain; Region: PRC; pfam05239 604162007057 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 604162007058 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 604162007059 Transposon insertion site of 92/38 mutant 604162007060 Transposon insertion site of 49/29 mutant 604162007061 Transposon insertion site of 45/22 mutant 604162007062 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 604162007063 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 604162007064 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 604162007065 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 604162007066 ABC-ATPase subunit interface; other site 604162007067 dimer interface [polypeptide binding]; other site 604162007068 putative PBP binding regions; other site 604162007069 Transposon insertion site of 10/10 mutant 604162007070 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 604162007071 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 604162007072 metal binding site [ion binding]; metal-binding site 604162007073 Transposon insertion site of 53/25 mutant 604162007074 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 604162007075 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 604162007076 Transposon insertion site of 61/46 mutant 604162007077 Transposon insertion site of 27/28 mutant 604162007078 Transposon insertion site of 61/17 mutant 604162007079 Transposon insertion site of 35/20 mutant 604162007080 Transposon insertion site of 63/26 mutant 604162007081 Transposon insertion site of 78/23 mutant 604162007082 Transposon insertion site of 60/9 mutant 604162007083 Transposon insertion site of 86/42 mutant 604162007084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 604162007085 Transposon insertion site of 86/40 mutant 604162007086 Transposon insertion site of 44/8 mutant 604162007087 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 604162007088 putative active site [active] 604162007089 Transposon insertion site of 52/36 mutant 604162007090 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 604162007091 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 604162007092 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 604162007093 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 604162007094 Transposon insertion site of 57/20 mutant 604162007095 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 604162007096 Transposon insertion site of 3/25 mutant 604162007097 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 604162007098 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 604162007099 Walker A/P-loop; other site 604162007100 ATP binding site [chemical binding]; other site 604162007101 Q-loop/lid; other site 604162007102 ABC transporter signature motif; other site 604162007103 Walker B; other site 604162007104 D-loop; other site 604162007105 H-loop/switch region; other site 604162007106 Evidence 7 : Gene remnant; Product type pf : putative factor 604162007107 Transposon insertion site of 57/7 mutant 604162007108 Transposon insertion site of 90/29 mutant 604162007109 Transposon insertion site of 18/33 mutant 604162007110 Transposon insertion site of 18/16 mutant 604162007111 Evidence 7 : Gene remnant; Product type pf : putative factor 604162007112 Evidence 7 : Gene remnant; Product type pf : putative factor 604162007113 Transposon insertion site of 30/26 mutant 604162007114 Transposon insertion site of 29/36 mutant 604162007115 Transposon insertion site of 36/23 mutant 604162007116 Transposon insertion site of 34/33 mutant 604162007117 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 604162007118 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 604162007119 tRNA; other site 604162007120 putative tRNA binding site [nucleotide binding]; other site 604162007121 putative NADP binding site [chemical binding]; other site 604162007122 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 604162007123 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 604162007124 lipoyl attachment site [posttranslational modification]; other site 604162007125 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 604162007126 Transposon insertion site of 42/31 mutant 604162007127 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 604162007128 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 604162007129 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 604162007130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 604162007131 putative DNA binding site [nucleotide binding]; other site 604162007132 putative Zn2+ binding site [ion binding]; other site 604162007133 AsnC family; Region: AsnC_trans_reg; pfam01037 604162007134 Transposon insertion site of 1850/1 mutant 604162007135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3310 604162007136 Transposon insertion site of 70/11 mutant 604162007137 Transposon insertion site of 73/18 mutant 604162007138 Transposon insertion site of 40/38 mutant 604162007139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 604162007140 Transposon insertion site of 11/26 mutant 604162007141 Transposon insertion site of 78/22 mutant 604162007142 Transposon insertion site of 13/22 and 50/42 mutants 604162007143 Transposon insertion site of 10/24 mutant 604162007144 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 604162007145 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 604162007146 transmembrane helices; other site 604162007147 Transposon insertion site of 51/14 mutant 604162007148 Transposon insertion site of 32/24 mutant 604162007149 Transposon insertion site of 19/19 mutant 604162007150 Transposon insertion site of 28/21 mutant 604162007151 Transposon insertion site of 42/45 mutant 604162007152 Transposon insertion site of 95/42 mutant 604162007153 Transposon insertion site of 10/44 mutant 604162007154 Transposon insertion site of 13/25 mutant 604162007155 Transposon insertion site of 19/27 mutant 604162007156 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 604162007157 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 604162007158 E3 interaction surface; other site 604162007159 lipoyl attachment site [posttranslational modification]; other site 604162007160 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 604162007161 Transposon insertion site of 96/39 mutant 604162007162 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 604162007163 Transposon insertion site of 40/2 mutant 604162007164 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 604162007165 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 604162007166 Transposon insertion site of 12/45 mutant 604162007167 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 604162007168 Transposon insertion site of 68/43 mutant 604162007169 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 604162007170 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 604162007171 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 604162007172 catalytic loop [active] 604162007173 iron binding site [ion binding]; other site 604162007174 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 604162007175 FAD binding pocket [chemical binding]; other site 604162007176 FAD binding motif [chemical binding]; other site 604162007177 phosphate binding motif [ion binding]; other site 604162007178 beta-alpha-beta structure motif; other site 604162007179 NAD binding pocket [chemical binding]; other site 604162007180 Transposon insertion site of 90/34 mutant 604162007181 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 604162007182 ApbE family; Region: ApbE; pfam02424 604162007183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 604162007184 GrpE; Region: GrpE; pfam01025 604162007185 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 604162007186 dimer interface [polypeptide binding]; other site 604162007187 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 604162007188 serine acetyltransferase; Provisional; Region: cysE; PRK11132 604162007189 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 604162007190 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 604162007191 trimer interface [polypeptide binding]; other site 604162007192 active site 604162007193 substrate binding site [chemical binding]; other site 604162007194 CoA binding site [chemical binding]; other site 604162007195 Transposon insertion site of 67/24 mutant 604162007196 Transposon insertion site of 49/39 mutant 604162007197 Transposon insertion site of 3/40 mutant 604162007198 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 604162007199 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 604162007200 Transposon insertion site of 92/15 mutant 604162007201 Transposon insertion site of 6/10 mutant 604162007202 Transposon insertion site of 59/5 mutant 604162007203 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 604162007204 Predicted transcriptional regulator [Transcription]; Region: COG2932 604162007205 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 604162007206 Catalytic site [active] 604162007207 Transposon insertion site of 64/4 mutant 604162007208 Transposon insertion site of 41/22 mutant 604162007209 Transposon insertion site of 23/24 mutant 604162007210 Transposon insertion site of 53/10 mutant 604162007211 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 604162007212 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 604162007213 nucleotide binding site [chemical binding]; other site 604162007214 NEF interaction site [polypeptide binding]; other site 604162007215 SBD interface [polypeptide binding]; other site 604162007216 Transposon insertion site of 77/36 mutant 604162007217 Transposon insertion site of 89/46 mutant 604162007218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 604162007219 Transposase; Region: DEDD_Tnp_IS110; pfam01548 604162007220 B-Box C-terminal domain; Region: BBC; smart00502 604162007221 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 604162007222 Evidence 4 : Homologs of previously reported genes of unknown function 604162007223 Evidence 4 : Homologs of previously reported genes of unknown function 604162007224 Transposon insertion site of 46/37 mutant 604162007225 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 604162007226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 604162007227 ATP binding site [chemical binding]; other site 604162007228 putative Mg++ binding site [ion binding]; other site 604162007229 helicase superfamily c-terminal domain; Region: HELICc; smart00490 604162007230 ATP-binding site [chemical binding]; other site 604162007231 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 604162007232 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 604162007233 dimerization domain [polypeptide binding]; other site 604162007234 dimer interface [polypeptide binding]; other site 604162007235 catalytic residues [active] 604162007236 Transposon insertion site of 54/21 mutant 604162007237 Transposon insertion site of 62/2 mutant 604162007238 Transposon insertion site of 58/44 mutant 604162007239 Transposon insertion site of 7/9 mutant 604162007240 Transposon insertion site of 10/18 mutant 604162007241 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 604162007242 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 604162007243 Walker A/P-loop; other site 604162007244 ATP binding site [chemical binding]; other site 604162007245 Q-loop/lid; other site 604162007246 ABC transporter signature motif; other site 604162007247 Walker B; other site 604162007248 D-loop; other site 604162007249 H-loop/switch region; other site 604162007250 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 604162007251 FtsX-like permease family; Region: FtsX; pfam02687 604162007252 Transposon insertion site of 92/43 mutant 604162007253 Transposon insertion site of 87/13 mutant 604162007254 macrolide transporter subunit MacA; Provisional; Region: PRK11578 604162007255 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 604162007256 HlyD family secretion protein; Region: HlyD_3; pfam13437 604162007257 Transposon insertion site of 73/44 mutant 604162007258 Transposon insertion site of 68/4 mutant 604162007259 Transposon insertion site of 33/30 mutant 604162007260 Transposon insertion site of 43/39 mutant 604162007261 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 604162007262 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 604162007263 Transposon insertion site of 11/24 mutant 604162007264 Transposon insertion site of 30/14 mutant 604162007265 Transposon insertion site of 14/22 mutant 604162007266 Transposon insertion site of 7/29 mutant 604162007267 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 604162007268 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 604162007269 NAD binding site [chemical binding]; other site 604162007270 substrate binding site [chemical binding]; other site 604162007271 catalytic Zn binding site [ion binding]; other site 604162007272 tetramer interface [polypeptide binding]; other site 604162007273 structural Zn binding site [ion binding]; other site 604162007274 Transposon insertion site of 51/22 mutant 604162007275 Transposon insertion site of 7/20 mutant 604162007276 Transposon insertion site of 66/20 mutant 604162007277 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 604162007278 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 604162007279 Walker A/P-loop; other site 604162007280 ATP binding site [chemical binding]; other site 604162007281 Q-loop/lid; other site 604162007282 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 604162007283 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 604162007284 ABC transporter signature motif; other site 604162007285 Walker B; other site 604162007286 D-loop; other site 604162007287 H-loop/switch region; other site 604162007288 Transposon insertion site of 74/15 mutant 604162007289 Transposon insertion site of 55/36 mutant 604162007290 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 604162007291 putative active site [active] 604162007292 putative metal binding site [ion binding]; other site 604162007293 Transposon insertion site of 48/40 mutant 604162007294 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 604162007295 L-lactate permease; Region: Lactate_perm; cl00701 604162007296 Transposon insertion site of 41/25 mutant 604162007297 Transposon insertion site of 65/38 mutant 604162007298 Transposon insertion site of 43/33 mutant 604162007299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 604162007300 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 604162007301 Transposon insertion site of 14/7 mutant 604162007302 Transposon insertion site of 4/19 mutant 604162007303 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 604162007304 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 604162007305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162007306 homodimer interface [polypeptide binding]; other site 604162007307 catalytic residue [active] 604162007308 Transposon insertion site of 81/12 mutant 604162007309 Transposon insertion site of 76/24 mutant 604162007310 Transposon insertion site of 8/45 mutant 604162007311 Transposon insertion site of 65/7 mutant 604162007312 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 604162007313 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 604162007314 domain interfaces; other site 604162007315 active site 604162007316 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 604162007317 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 604162007318 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 604162007319 Transporter associated domain; Region: CorC_HlyC; smart01091 604162007320 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 604162007321 Transposon insertion site of 15/40 mutant 604162007322 Transposon insertion site of 18/6 mutant 604162007323 Transposon insertion site of 1/2 mutant 604162007324 Transposon insertion site of 83/29 mutant 604162007325 Transposon insertion site of 25/15 mutant 604162007326 Transposon insertion site of 57/27 mutant 604162007327 Transposon insertion site of 89/45 mutant 604162007328 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 604162007329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 604162007330 putative substrate translocation pore; other site 604162007331 Transposon insertion site of 21/43 mutant 604162007332 Transposon insertion site of 2/14 mutant 604162007333 Transposon insertion site of 5/47 mutant 604162007334 Transposon insertion site of 37/15 mutant 604162007335 Transposon insertion site of 79/20 mutant 604162007336 Transposon insertion site of 39/31 mutant 604162007337 Transposon insertion site of 35/40 mutant 604162007338 Transposon insertion site of 81/37 mutant 604162007339 Predicted membrane protein [Function unknown]; Region: COG1238 604162007340 Transposon insertion site of 76/17 mutant 604162007341 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 604162007342 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 604162007343 minor groove reading motif; other site 604162007344 helix-hairpin-helix signature motif; other site 604162007345 substrate binding pocket [chemical binding]; other site 604162007346 active site 604162007347 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 604162007348 Transposon insertion site of 66/33 mutant 604162007349 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 604162007350 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 604162007351 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 604162007352 protein binding site [polypeptide binding]; other site 604162007353 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 604162007354 protein binding site [polypeptide binding]; other site 604162007355 Transposon insertion site of 68/21 mutant 604162007356 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 604162007357 Transposon insertion site of 78/35 mutant 604162007358 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 604162007359 beta-hexosaminidase; Provisional; Region: PRK05337 604162007360 Transposon insertion site of 73/33 mutant 604162007361 Transposon insertion site of 38/45 mutant 604162007362 Transposon insertion site of 4/4 mutant 604162007363 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 604162007364 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 604162007365 FeS/SAM binding site; other site 604162007366 Transposon insertion site of 16/11 mutant 604162007367 Transposon insertion site of 32/41 mutant 604162007368 Predicted membrane protein [Function unknown]; Region: COG3759 604162007369 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 604162007370 active site 604162007371 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 604162007372 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 604162007373 Ligand Binding Site [chemical binding]; other site 604162007374 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 604162007375 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 604162007376 Evidence 7 : Gene remnant; Product type pe : putative enzyme 604162007377 Transposon insertion site of 53/22 mutant 604162007378 Transposon insertion site of 34/38 mutant 604162007379 Transposon insertion site of 35/42 mutant 604162007380 Transposon insertion site of 19/18 mutant 604162007381 Transposon insertion site of 32/19 mutant 604162007382 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162007383 Transposon insertion site of 62/45 mutant 604162007384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 604162007385 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16472308; Product type pf : putative factor' 604162007386 haemagglutination activity domain; Region: Haemagg_act; pfam05860 604162007387 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 604162007388 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 604162007389 Transposon insertion site of 82/8 mutant 604162007390 Transposon insertion site of 27/32 mutant 604162007391 Transposon insertion site of 14/31 mutant 604162007392 Transposon insertion site of 48/7 mutant 604162007393 Transposon insertion site of 16/2 mutant 604162007394 Transposon insertion site of 3/24 mutant 604162007395 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 604162007396 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 604162007397 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 604162007398 Evidence 7 : Gene remnant; Product type pe : putative enzyme 604162007399 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter' 604162007400 Transposon insertion site of 80/36 mutant 604162007401 Transposon insertion site of 93/4 mutant 604162007402 Transposon insertion site of 61/29 mutant 604162007403 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter' 604162007404 Transposon insertion site of 23/9 mutant 604162007405 Transposon insertion site of 8/33 mutant 604162007406 Transposon insertion site of 30/46 mutant 604162007407 Evidence 4 : Homologs of previously reported genes of unknown function 604162007408 Transposon insertion site of 81/41 mutant 604162007409 Transposon insertion site of 29/37 mutant 604162007410 Evidence 4 : Homologs of previously reported genes of unknown function 604162007411 Transposon insertion site of 8/29 mutant 604162007412 Transposon insertion site of 85/2 mutant 604162007413 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 604162007414 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 604162007415 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 604162007416 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 604162007417 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 604162007418 generic binding surface II; other site 604162007419 ssDNA binding site; other site 604162007420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 604162007421 ATP binding site [chemical binding]; other site 604162007422 putative Mg++ binding site [ion binding]; other site 604162007423 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 604162007424 nucleotide binding region [chemical binding]; other site 604162007425 ATP-binding site [chemical binding]; other site 604162007426 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 604162007427 SecA binding site; other site 604162007428 Preprotein binding site; other site 604162007429 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 604162007430 GSH binding site [chemical binding]; other site 604162007431 catalytic residues [active] 604162007432 ribonuclease G; Provisional; Region: PRK11712 604162007433 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 604162007434 homodimer interface [polypeptide binding]; other site 604162007435 oligonucleotide binding site [chemical binding]; other site 604162007436 Transposon insertion site of 69/23 mutant 604162007437 sensor protein QseC; Provisional; Region: PRK10337 604162007438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 604162007439 dimer interface [polypeptide binding]; other site 604162007440 phosphorylation site [posttranslational modification] 604162007441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 604162007442 ATP binding site [chemical binding]; other site 604162007443 Mg2+ binding site [ion binding]; other site 604162007444 G-X-G motif; other site 604162007445 Transposon insertion site of 68/5 mutant 604162007446 Transposon insertion site of 1/14 mutant 604162007447 Transposon insertion site of 17/30 mutant 604162007448 Transposon insertion site of 28/44 mutant 604162007449 Evidence 7 : Gene remnant; Product type pr : putative regulator 604162007450 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 604162007451 Citrate transporter; Region: CitMHS; pfam03600 604162007452 Transposon insertion site of 85/6 mutant 604162007453 Transposon insertion site of 66/22 mutant 604162007454 Predicted flavoprotein [General function prediction only]; Region: COG0431 604162007455 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 604162007456 Transposon insertion site of 96/3 mutant 604162007457 Transposon insertion site of 10/13 and 55/7 mutants 604162007458 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 604162007459 Transposon insertion site of 67/4 mutant 604162007460 Transposon insertion site of 35/16 mutant 604162007461 Transposon insertion site of 43/36 mutant 604162007462 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162007463 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162007464 Transposase domain (DUF772); Region: DUF772; pfam05598 604162007465 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 604162007466 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 604162007467 Transposon insertion site of 22/19 mutant 604162007468 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 604162007469 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 604162007470 HlyD family secretion protein; Region: HlyD_3; pfam13437 604162007471 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 604162007472 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 604162007473 putative active site [active] 604162007474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 604162007475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 604162007476 Walker A/P-loop; other site 604162007477 ATP binding site [chemical binding]; other site 604162007478 Q-loop/lid; other site 604162007479 ABC transporter signature motif; other site 604162007480 Walker B; other site 604162007481 D-loop; other site 604162007482 H-loop/switch region; other site 604162007483 Transposon insertion site of 1/29 mutant 604162007484 Transposon insertion site of 7/23 mutant 604162007485 Transposon insertion site of 31/31 mutant 604162007486 Transposon insertion site of 54/3 mutant 604162007487 Transposon insertion site of 89/24 mutant 604162007488 Transposon insertion site of 63/13 mutant 604162007489 Uncharacterized conserved protein [Function unknown]; Region: COG2850 604162007490 Cupin-like domain; Region: Cupin_8; pfam13621 604162007491 Transposon insertion site of 30/41 mutant 604162007492 Transposon insertion site of 29/5 mutant 604162007493 Transposon insertion site of 26/38 mutant 604162007494 Transposon insertion site of 53/19 mutant 604162007495 Transposon insertion site of 1/43 mutant 604162007496 Transposon insertion site of 15/17 mutant 604162007497 Transposon insertion site of 82/27 mutant 604162007498 Transposon insertion site of 16/36 mutant 604162007499 Transposon insertion site of 52/28 mutant 604162007500 Transposon insertion site of 71/43 mutant 604162007501 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor' 604162007502 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor' 604162007503 Transposon insertion site of 69/22 mutant 604162007504 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162007505 Transposon insertion site of 88/5 mutant 604162007506 Transposon insertion site of 24/25 mutant 604162007507 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162007508 Transposon insertion site of 1/6 mutant 604162007509 S-adenosylmethionine synthetase; Validated; Region: PRK05250 604162007510 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 604162007511 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 604162007512 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 604162007513 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 604162007514 putative acyl-acceptor binding pocket; other site 604162007515 UGMP family protein; Validated; Region: PRK09604 604162007516 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 604162007517 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 604162007518 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 604162007519 ResB-like family; Region: ResB; pfam05140 604162007520 Cytochrome c553 [Energy production and conversion]; Region: COG2863 604162007521 Cytochrome c; Region: Cytochrom_C; cl11414 604162007522 Transposon insertion site of 9/14 mutant 604162007523 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 604162007524 G1 box; other site 604162007525 GTP/Mg2+ binding site [chemical binding]; other site 604162007526 Switch I region; other site 604162007527 G2 box; other site 604162007528 G3 box; other site 604162007529 Switch II region; other site 604162007530 G4 box; other site 604162007531 G5 box; other site 604162007532 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 604162007533 Transglycosylase; Region: Transgly; pfam00912 604162007534 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 604162007535 Transposon insertion site of 33/33 mutant 604162007536 Transposon insertion site of 42/15 mutant 604162007537 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 604162007538 Transposon insertion site of 19/33 mutant 604162007539 Transposon insertion site of 38/22 mutant 604162007540 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 604162007541 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 604162007542 Transposon insertion site of pil1 mutant 604162007543 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 604162007544 Transposon insertion site of N-P mutant 604162007545 Transposon insertion site of pN-P mutant 604162007546 Transposon insertion site of B mutant 604162007547 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 604162007548 Pilus assembly protein, PilP; Region: PilP; pfam04351 604162007549 Transposon insertion site of A mutant 604162007550 Transposon insertion site of C mutant 604162007551 Transposon insertion site of 10/33 mutant 604162007552 AMIN domain; Region: AMIN; pfam11741 604162007553 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 604162007554 Secretin and TonB N terminus short domain; Region: STN; pfam07660 604162007555 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 604162007556 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 604162007557 Transposon insertion site of 72/13 mutant 604162007558 Transposon insertion site of 69/38 mutant 604162007559 Transposon insertion site of 57/47 mutant 604162007560 Transposon insertion site of 46/6 mutant 604162007561 Transposon insertion site of 40/8 mutant 604162007562 Transposon insertion site of 4/40 mutant 604162007563 shikimate kinase; Reviewed; Region: aroK; PRK00131 604162007564 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 604162007565 ADP binding site [chemical binding]; other site 604162007566 magnesium binding site [ion binding]; other site 604162007567 putative shikimate binding site; other site 604162007568 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 604162007569 active site 604162007570 dimer interface [polypeptide binding]; other site 604162007571 metal binding site [ion binding]; metal-binding site 604162007572 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 604162007573 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 604162007574 putative active site [active] 604162007575 putative dimer interface [polypeptide binding]; other site 604162007576 Transposon insertion site of 7/16 mutant 604162007577 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 604162007578 ATP cone domain; Region: ATP-cone; pfam03477 604162007579 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 604162007580 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 604162007581 catalytic motif [active] 604162007582 Zn binding site [ion binding]; other site 604162007583 RibD C-terminal domain; Region: RibD_C; cl17279 604162007584 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 604162007585 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 604162007586 Transposon insertion site of 70/19 mutant 604162007587 Transposon insertion site of 43/13 mutant 604162007588 Transposon insertion site of 40/37 mutant 604162007589 Transposon insertion site of 45/1 mutant 604162007590 Transposon insertion site of 25/20 mutant 604162007591 Bacterial sugar transferase; Region: Bac_transf; pfam02397 604162007592 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 604162007593 ATP-grasp domain; Region: ATP-grasp_4; cl17255 604162007594 Transposon insertion site of 41/9 mutant 604162007595 Transposon insertion site of 93/45 mutant 604162007596 Transposon insertion site of 90/45 mutant 604162007597 Transposon insertion site of 77/11 mutant 604162007598 Transposon insertion site of 12/23 mutant 604162007599 Transposon insertion site of 22/48 mutant 604162007600 Transposon insertion site of 16/15 mutant 604162007601 Transposon insertion site of 75/26 mutant 604162007602 Transposon insertion site of 84/1 mutant 604162007603 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 604162007604 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 604162007605 Transposon insertion site of 44/30 mutant 604162007606 Transposon insertion site of 23/36 mutant 604162007607 Transposon insertion site of 79/21 mutant 604162007608 Transposon insertion site of 2/35 mutant 604162007609 Transposon insertion site of 13/1 mutant 604162007610 Transposon insertion site of 82/17 mutant 604162007611 Transposon insertion site of 91/43 mutant 604162007612 Transposon insertion site of 27/46 mutant 604162007613 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 604162007614 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 604162007615 inhibitor-cofactor binding pocket; inhibition site 604162007616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162007617 catalytic residue [active] 604162007618 Transposon insertion site of 68/25 mutant 604162007619 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 604162007620 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 604162007621 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 604162007622 NAD(P) binding site [chemical binding]; other site 604162007623 homodimer interface [polypeptide binding]; other site 604162007624 substrate binding site [chemical binding]; other site 604162007625 active site 604162007626 Transposon insertion site of 34/47 mutant 604162007627 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and metabolism]; Region: COG3977 604162007628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 604162007629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162007630 homodimer interface [polypeptide binding]; other site 604162007631 catalytic residue [active] 604162007632 Transposon insertion site of 7/22 mutant 604162007633 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 604162007634 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 604162007635 active site 604162007636 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 604162007637 Transposon insertion site of 19/47 mutant 604162007638 Transposon insertion site of 23/10 mutant 604162007639 Transposon insertion site of 62/1 mutant 604162007640 Transposon insertion site of 55/26 mutant 604162007641 Transposon insertion site of 41/8 mutant 604162007642 Transposon insertion site of 24/42 mutant 604162007643 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 604162007644 RNA binding surface [nucleotide binding]; other site 604162007645 Transposon insertion site of 28/37 mutant 604162007646 Transposon insertion site of 93/34 mutant 604162007647 Transposon insertion site of 27/6 mutant 604162007648 Transposon insertion site of 18/20 mutant 604162007649 Transposon insertion site of 29/27 mutant 604162007650 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 604162007651 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 604162007652 putative active site [active] 604162007653 putative PHP Thumb interface [polypeptide binding]; other site 604162007654 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 604162007655 generic binding surface II; other site 604162007656 generic binding surface I; other site 604162007657 Transposon insertion site of 5/3 mutant 604162007658 Transposon insertion site of 81/46 mutant 604162007659 Transposon insertion site of 34/14 mutant 604162007660 Transposon insertion site of 6/46 mutant 604162007661 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 604162007662 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 604162007663 Transposon insertion site of 23/6 mutant 604162007664 Transposon insertion site of 60/31 mutant 604162007665 Transposon insertion site of 15/22 mutant 604162007666 Transposon insertion site of 9/23 mutant 604162007667 Transposon insertion site of 34/9 mutant 604162007668 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 604162007669 Transposon insertion site of 10/4 mutant 604162007670 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 604162007671 Transposon insertion site of 71/27 mutant 604162007672 Transposon insertion site of 9/6 mutant 604162007673 Transposon insertion site of 1/36 mutant 604162007674 Transposon insertion site of 43/29 mutant 604162007675 Transposon insertion site of 10/35 mutant 604162007676 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162007677 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 604162007678 Transposon insertion site of 19/26 mutant 604162007679 Transposon insertion site of 65/6 mutant 604162007680 Transposon insertion site of 20/40 mutant 604162007681 Transposon insertion site of 82/15 mutant 604162007682 Evidence 4 : Homologs of previously reported genes of unknown function 604162007683 Transposon insertion site of 21/15 mutant 604162007684 Evidence 4 : Homologs of previously reported genes of unknown function 604162007685 Transposon insertion site of 23/39 mutant 604162007686 Evidence 7 : Gene remnant; Product type pf : putative factor 604162007687 Transposon insertion site of 33/19 mutant 604162007688 Transposon insertion site of 38/42 mutant 604162007689 Evidence 7 : Gene remnant; Product type pf : putative factor 604162007690 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 604162007691 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 604162007692 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 604162007693 N-terminal plug; other site 604162007694 ligand-binding site [chemical binding]; other site 604162007695 Transposon insertion site of 65/16 mutant 604162007696 Transposon insertion site of 47/2 mutant 604162007697 Transposon insertion site of 4/32 mutant 604162007698 Transposon insertion site of 4/10 mutant 604162007699 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 604162007700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 604162007701 motif II; other site 604162007702 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 604162007703 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 604162007704 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 604162007705 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 604162007706 lipoprotein signal peptidase; Provisional; Region: PRK14787 604162007707 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 604162007708 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 604162007709 active site 604162007710 HIGH motif; other site 604162007711 nucleotide binding site [chemical binding]; other site 604162007712 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 604162007713 active site 604162007714 KMSKS motif; other site 604162007715 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 604162007716 tRNA binding surface [nucleotide binding]; other site 604162007717 anticodon binding site; other site 604162007718 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 604162007719 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 604162007720 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 604162007721 active site 604162007722 Riboflavin kinase; Region: Flavokinase; smart00904 604162007723 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 604162007724 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 604162007725 active site 604162007726 HIGH motif; other site 604162007727 dimer interface [polypeptide binding]; other site 604162007728 KMSKS motif; other site 604162007729 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 604162007730 Transposon insertion site of 47/14 mutant 604162007731 Transposon insertion site of 31/22 mutant 604162007732 Transposon insertion site of 71/36 mutant 604162007733 Transposon insertion site of 96/11 mutant 604162007734 Transposon insertion site of 81/8 mutant 604162007735 Transposon insertion site of 70/36 mutant 604162007736 Transposon insertion site of 32/36 mutant 604162007737 GTP-binding protein YchF; Reviewed; Region: PRK09601 604162007738 YchF GTPase; Region: YchF; cd01900 604162007739 G1 box; other site 604162007740 GTP/Mg2+ binding site [chemical binding]; other site 604162007741 Switch I region; other site 604162007742 G2 box; other site 604162007743 Switch II region; other site 604162007744 G3 box; other site 604162007745 G4 box; other site 604162007746 G5 box; other site 604162007747 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 604162007748 Transposon insertion site of 5/14 mutant 604162007749 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 604162007750 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 604162007751 Potassium binding sites [ion binding]; other site 604162007752 Cesium cation binding sites [ion binding]; other site 604162007753 Predicted membrane protein [Function unknown]; Region: COG2510 604162007754 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 604162007755 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 604162007756 Substrate binding site; other site 604162007757 metal-binding site 604162007758 4-hydroxyphenylacetate 3-monooxygenase, reductase component; Region: HpaC; TIGR02296 604162007759 Transposon insertion site of 61/43 mutant 604162007760 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 604162007761 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 604162007762 Transposon insertion site of 92/41 mutant 604162007763 Transposon insertion site of 21/10 mutant 604162007764 Transposon insertion site of 6/15 mutant 604162007765 Transposon insertion site of 60/24 mutant 604162007766 Transposon insertion site of 59/20 mutant 604162007767 Transposon insertion site of 81/24 mutant 604162007768 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 604162007769 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 604162007770 Transposon insertion site of 26/7 mutant 604162007771 antiporter inner membrane protein; Provisional; Region: PRK11670 604162007772 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 604162007773 Transposon insertion site of 51/18 mutant 604162007774 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 604162007775 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 604162007776 Transposon insertion site of 78/48 mutant 604162007777 Transposon insertion site of 50/3 mutant 604162007778 Transposon insertion site of 48/11 mutant 604162007779 Transposon insertion site of 50/12 mutant 604162007780 Transposon insertion site of 38/36 mutant 604162007781 Transposon insertion site of 40/16 mutant 604162007782 Transposon insertion site of 79/27 mutant 604162007783 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 604162007784 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 604162007785 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 604162007786 catalytic site [active] 604162007787 subunit interface [polypeptide binding]; other site 604162007788 Evidence 7 : Gene remnant; Product type pe : putative enzyme 604162007789 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 604162007790 putative active site [active] 604162007791 Transposon insertion site of 43/48 mutant 604162007792 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 604162007793 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 604162007794 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 604162007795 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 604162007796 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 604162007797 ATP-grasp domain; Region: ATP-grasp_4; cl17255 604162007798 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 604162007799 IMP binding site; other site 604162007800 dimer interface [polypeptide binding]; other site 604162007801 interdomain contacts; other site 604162007802 partial ornithine binding site; other site 604162007803 Transposon insertion site of 2/13 mutant 604162007804 Transposon insertion site of 94/39 mutant 604162007805 Transposon insertion site of 55/32 mutant 604162007806 Transposon insertion site of 74/24 mutant 604162007807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 604162007808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 604162007809 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 604162007810 putative effector binding pocket; other site 604162007811 dimerization interface [polypeptide binding]; other site 604162007812 Transposon insertion site of 77/10 mutant 604162007813 Transposon insertion site of 47/37 mutant 604162007814 Transposon insertion site of 58/19 mutant 604162007815 Transposon insertion site of 82/20 mutant 604162007816 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 604162007817 Transposon insertion site of 11/28 mutant 604162007818 Transposon insertion site of 33/6 mutant 604162007819 Transposon insertion site of 83/33 mutant 604162007820 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 604162007821 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 604162007822 Transposon insertion site of 96/23 mutant 604162007823 Transposon insertion site of 91/2 mutant 604162007824 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 604162007825 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 604162007826 carboxyltransferase (CT) interaction site; other site 604162007827 biotinylation site [posttranslational modification]; other site 604162007828 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 604162007829 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 604162007830 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 604162007831 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 604162007832 Transposon insertion site of 3/1 mutant 604162007833 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 604162007834 DNA methylase; Region: N6_N4_Mtase; cl17433 604162007835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162007836 S-adenosylmethionine binding site [chemical binding]; other site 604162007837 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 604162007838 catalytic site [active] 604162007839 putative active site [active] 604162007840 putative substrate binding site [chemical binding]; other site 604162007841 dimer interface [polypeptide binding]; other site 604162007842 Transposon insertion site of 14/25 mutant 604162007843 Transposon insertion site of 20/31 mutant 604162007844 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 604162007845 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 604162007846 inhibitor-cofactor binding pocket; inhibition site 604162007847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162007848 catalytic residue [active] 604162007849 Transposon insertion site of 47/10 mutant 604162007850 Transposon insertion site of 89/17 mutant 604162007851 Transposon insertion site of 37/10 mutant 604162007852 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 604162007853 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 604162007854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 604162007855 FeS/SAM binding site; other site 604162007856 TRAM domain; Region: TRAM; pfam01938 604162007857 Transposon insertion site of 72/43 mutant 604162007858 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 604162007859 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 604162007860 TPP-binding site; other site 604162007861 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 604162007862 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 604162007863 PYR/PP interface [polypeptide binding]; other site 604162007864 dimer interface [polypeptide binding]; other site 604162007865 TPP binding site [chemical binding]; other site 604162007866 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 604162007867 Transposon insertion site of 41/2 mutant 604162007868 Transposon insertion site of 40/11 mutant 604162007869 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 604162007870 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 604162007871 active site 604162007872 Int/Topo IB signature motif; other site 604162007873 Transposon insertion site of 34/15 mutant 604162007874 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 604162007875 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 604162007876 intersubunit interface [polypeptide binding]; other site 604162007877 active site 604162007878 zinc binding site [ion binding]; other site 604162007879 Na+ binding site [ion binding]; other site 604162007880 Transposon insertion site of 21/47 mutant 604162007881 Transposon insertion site of 21/25 mutant 604162007882 Transposon insertion site of 88/22 mutant 604162007883 Lipoprotein GNA1870 C terminal like; Region: Lipoprot_C; pfam08794 604162007884 Transposon insertion site of 56/40 mutant 604162007885 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 604162007886 Glycoprotease family; Region: Peptidase_M22; pfam00814 604162007887 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 604162007888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 604162007889 Coenzyme A binding pocket [chemical binding]; other site 604162007890 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 604162007891 active site 604162007892 Fe-S cluster binding site [ion binding]; other site 604162007893 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 604162007894 active site 604162007895 Transposon insertion site of 19/36 mutant 604162007896 Transposon insertion site of 57/31 mutant 604162007897 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 604162007898 amino-acid N-acetyltransferase; Region: N-Ac-Glu-synth; TIGR01890 604162007899 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 604162007900 putative feedback inhibition sensing region; other site 604162007901 putative nucleotide binding site [chemical binding]; other site 604162007902 putative substrate binding site [chemical binding]; other site 604162007903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 604162007904 Coenzyme A binding pocket [chemical binding]; other site 604162007905 Transposon insertion site of 7/25 mutant 604162007906 Transposon insertion site of 37/34 mutant 604162007907 Transposon insertion site of 75/36 mutant 604162007908 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 604162007909 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 604162007910 Transposon insertion site of 61/4 mutant 604162007911 Transposon insertion site of 21/30 mutant 604162007912 Transposon insertion site of 33/5 mutant 604162007913 Transposon insertion site of 34/43 mutant 604162007914 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 604162007915 Transposon insertion site of 2068/1 mutant 604162007916 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 604162007917 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 604162007918 putative ligand binding residues [chemical binding]; other site 604162007919 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 604162007920 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 604162007921 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 604162007922 N-terminal plug; other site 604162007923 ligand-binding site [chemical binding]; other site 604162007924 Transposon insertion site of 70/46 mutant 604162007925 Transposon insertion site of 67/8 mutant 604162007926 Transposon insertion site of 94/10 mutant 604162007927 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 604162007928 active site residue [active] 604162007929 Transposon insertion site of 49/12 mutant 604162007930 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 604162007931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162007932 S-adenosylmethionine binding site [chemical binding]; other site 604162007933 Transposon insertion site of 22/36 mutant 604162007934 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 604162007935 triosephosphate isomerase; Provisional; Region: PRK14567 604162007936 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 604162007937 substrate binding site [chemical binding]; other site 604162007938 dimer interface [polypeptide binding]; other site 604162007939 catalytic triad [active] 604162007940 Transposon insertion site of 24/41 mutant 604162007941 Transposon insertion site of 15/13 mutant 604162007942 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 604162007943 Predicted transcriptional regulator [Transcription]; Region: COG2944 604162007944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 604162007945 non-specific DNA binding site [nucleotide binding]; other site 604162007946 salt bridge; other site 604162007947 sequence-specific DNA binding site [nucleotide binding]; other site 604162007948 Transposon insertion site of 33/16 mutant 604162007949 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162007950 Transposon insertion site of 37/43 mutant 604162007951 Transposon insertion site of 21/6 mutant 604162007952 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162007953 Transposon insertion site of 54/16 mutant 604162007954 Dam-replacing family; Region: DRP; pfam06044 604162007955 Transposon insertion site of 80/35 mutant 604162007956 Transposon insertion site of 48/36 mutant 604162007957 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 604162007958 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 604162007959 HIGH motif; other site 604162007960 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 604162007961 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 604162007962 active site 604162007963 KMSKS motif; other site 604162007964 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 604162007965 tRNA binding surface [nucleotide binding]; other site 604162007966 Transposon insertion site of 53/29 mutant 604162007967 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 604162007968 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 604162007969 Transposon insertion site of 36/10 mutant 604162007970 Transposon insertion site of 89/13 mutant 604162007971 Transposon insertion site of 11/39 mutant 604162007972 Transposon insertion site of 79/30 mutant 604162007973 polyphosphate kinase; Provisional; Region: PRK05443 604162007974 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 604162007975 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 604162007976 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 604162007977 putative domain interface [polypeptide binding]; other site 604162007978 putative active site [active] 604162007979 catalytic site [active] 604162007980 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 604162007981 putative domain interface [polypeptide binding]; other site 604162007982 putative active site [active] 604162007983 catalytic site [active] 604162007984 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162007985 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162007986 Transposon insertion site of 49/3 mutant 604162007987 DNA polymerase III subunit beta; Validated; Region: PRK05643 604162007988 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 604162007989 putative DNA binding surface [nucleotide binding]; other site 604162007990 dimer interface [polypeptide binding]; other site 604162007991 beta-clamp/clamp loader binding surface; other site 604162007992 beta-clamp/translesion DNA polymerase binding surface; other site 604162007993 DnaA N-terminal domain; Region: DnaA_N; pfam11638 604162007994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 604162007995 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 604162007996 Walker A motif; other site 604162007997 ATP binding site [chemical binding]; other site 604162007998 Walker B motif; other site 604162007999 arginine finger; other site 604162008000 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 604162008001 DnaA box-binding interface [nucleotide binding]; other site 604162008002 Transposon insertion site of 65/29 mutant 604162008003 Transposon insertion site of 58/1 mutant 604162008004 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 604162008005 ribonuclease P; Reviewed; Region: rnpA; PRK04390 604162008006 Transposon insertion site of 79/44 mutant 604162008007 hypothetical protein; Provisional; Region: PRK14373 604162008008 Transposon insertion site of 46/23 mutant 604162008009 membrane protein insertase; Provisional; Region: PRK01318 604162008010 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 604162008011 Predicted methyltransferases [General function prediction only]; Region: COG0313 604162008012 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 604162008013 putative SAM binding site [chemical binding]; other site 604162008014 homodimer interface [polypeptide binding]; other site 604162008015 Transposon insertion site of 31/41 mutant 604162008016 Transposon insertion site of 81/32 mutant 604162008017 Transposon insertion site of 64/26 mutant 604162008018 Maf-like protein; Region: Maf; pfam02545 604162008019 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 604162008020 active site 604162008021 dimer interface [polypeptide binding]; other site 604162008022 Transposon insertion site of 17/32 mutant 604162008023 Transposon insertion site of 20/9 mutant 604162008024 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 604162008025 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 604162008026 Transposon insertion site of 31/12 mutant 604162008027 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 604162008028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 604162008029 active site 604162008030 Transposon insertion site of 68/10 mutant 604162008031 Transposon insertion site of 48/24 mutant 604162008032 putative phosphate acyltransferase; Provisional; Region: PRK05331 604162008033 Transposon insertion site of 1/34 mutant 604162008034 Transposon insertion site of 1/33 mutant 604162008035 Transposon insertion site of 89/42 mutant 604162008036 Transposon insertion site of 15/43 mutant 604162008037 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 604162008038 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 604162008039 dimer interface [polypeptide binding]; other site 604162008040 active site 604162008041 CoA binding pocket [chemical binding]; other site 604162008042 Predicted membrane protein [Function unknown]; Region: COG3326 604162008043 Transposon insertion site of 69/34 mutant 604162008044 Transposon insertion site of 47/45 mutant 604162008045 Transposon insertion site of 69/21 mutant 604162008046 Transposon insertion site of 62/48 mutant 604162008047 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 604162008048 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 604162008049 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 604162008050 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 604162008051 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 604162008052 Walker A/P-loop; other site 604162008053 ATP binding site [chemical binding]; other site 604162008054 Q-loop/lid; other site 604162008055 ABC transporter signature motif; other site 604162008056 Walker B; other site 604162008057 D-loop; other site 604162008058 H-loop/switch region; other site 604162008059 GMP synthase; Reviewed; Region: guaA; PRK00074 604162008060 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 604162008061 AMP/PPi binding site [chemical binding]; other site 604162008062 candidate oxyanion hole; other site 604162008063 catalytic triad [active] 604162008064 potential glutamine specificity residues [chemical binding]; other site 604162008065 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 604162008066 ATP Binding subdomain [chemical binding]; other site 604162008067 Ligand Binding sites [chemical binding]; other site 604162008068 Dimerization subdomain; other site 604162008069 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 604162008070 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 604162008071 NAD(P) binding site [chemical binding]; other site 604162008072 homotetramer interface [polypeptide binding]; other site 604162008073 homodimer interface [polypeptide binding]; other site 604162008074 active site 604162008075 Evidence 7 : Gene remnant; Product type e : enzyme 604162008076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 604162008077 Transposon insertion site of 82/44 mutant 604162008078 Transposon insertion site of 44/47 mutant 604162008079 Transposon insertion site of 44/48 mutant 604162008080 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162008081 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162008082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 604162008083 SEC-C motif; Region: SEC-C; pfam02810 604162008084 Transposon insertion site of 51/5 mutant 604162008085 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 604162008086 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 604162008087 active site 604162008088 Transposon insertion site of 75/31 mutant 604162008089 Transposon insertion site of 8/21 mutant 604162008090 RNA methyltransferase, RsmE family; Region: TIGR00046 604162008091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 604162008092 Transposon insertion site of 43/2 mutant 604162008093 Transposon insertion site of 79/25 mutant 604162008094 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 604162008095 Transposon insertion site of 83/19 mutant 604162008096 Transposon insertion site of 3/39 mutant 604162008097 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 604162008098 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 604162008099 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 604162008100 active site 604162008101 Transposon insertion site of 3/8 mutant 604162008102 Transposon insertion site of 45/34 mutant 604162008103 Transposon insertion site of 10/14 mutant 604162008104 Transposon insertion site of 21/21 mutant 604162008105 Transposon insertion site of 65/8 mutant 604162008106 Transposon insertion site of 17/5 mutant 604162008107 Transposon insertion site of 56/17 mutant 604162008108 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 604162008109 DALR anticodon binding domain; Region: DALR_1; pfam05746 604162008110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3171 604162008111 Transposon insertion site of 23/1 mutant 604162008112 Transposon insertion site of 64/7 mutant 604162008113 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 604162008114 dimer interface [polypeptide binding]; other site 604162008115 motif 1; other site 604162008116 active site 604162008117 motif 2; other site 604162008118 motif 3; other site 604162008119 Transposon insertion site of 57/29 mutant 604162008120 Transposon insertion site of 33/11 mutant 604162008121 Transposon insertion site of 55/8 mutant 604162008122 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 604162008123 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 604162008124 gamma subunit interface [polypeptide binding]; other site 604162008125 epsilon subunit interface [polypeptide binding]; other site 604162008126 LBP interface [polypeptide binding]; other site 604162008127 Transposon insertion site of 55/18 mutant 604162008128 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 604162008129 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 604162008130 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 604162008131 alpha subunit interaction interface [polypeptide binding]; other site 604162008132 Walker A motif; other site 604162008133 ATP binding site [chemical binding]; other site 604162008134 Walker B motif; other site 604162008135 inhibitor binding site; inhibition site 604162008136 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 604162008137 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 604162008138 core domain interface [polypeptide binding]; other site 604162008139 delta subunit interface [polypeptide binding]; other site 604162008140 epsilon subunit interface [polypeptide binding]; other site 604162008141 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 604162008142 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 604162008143 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 604162008144 beta subunit interaction interface [polypeptide binding]; other site 604162008145 Walker A motif; other site 604162008146 ATP binding site [chemical binding]; other site 604162008147 Walker B motif; other site 604162008148 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 604162008149 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 604162008150 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 604162008151 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 604162008152 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 604162008153 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 604162008154 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 604162008155 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 604162008156 F0F1-type ATP synthase, subunit I [Energy production and conversion]; Region: AtpI; COG3312 604162008157 Transposon insertion site of 8/23 mutant 604162008158 Transposon insertion site of 64/42 mutant 604162008159 Transposon insertion site of 93/17 mutant 604162008160 Transposon insertion site of 6/25 and 95/17 mutants 604162008161 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 604162008162 ParB-like nuclease domain; Region: ParBc; pfam02195 604162008163 KorB domain; Region: KorB; pfam08535 604162008164 Transposon insertion site of 42/27 mutant 604162008165 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 604162008166 Flavoprotein; Region: Flavoprotein; pfam02441 604162008167 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 604162008168 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 604162008169 Transposon insertion site of 44/40 mutant 604162008170 Transposon insertion site of 67/44 mutant 604162008171 Transposon insertion site of 6/12 mutant 604162008172 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 604162008173 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 604162008174 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 604162008175 Walker A/P-loop; other site 604162008176 ATP binding site [chemical binding]; other site 604162008177 Q-loop/lid; other site 604162008178 ABC transporter signature motif; other site 604162008179 Walker B; other site 604162008180 D-loop; other site 604162008181 H-loop/switch region; other site 604162008182 Transposon insertion site of 67/17 mutant 604162008183 Transposon insertion site of 91/42 mutant 604162008184 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 604162008185 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 604162008186 N-acetyl-D-glucosamine binding site [chemical binding]; other site 604162008187 catalytic residue [active] 604162008188 Transposon insertion site of 58/21 mutant 604162008189 Transposon insertion site of 11/17 mutant 604162008190 Transposon insertion site of 6/19 mutant 604162008191 Transposon insertion site of 84/41 mutant 604162008192 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 604162008193 Transposon insertion site of 88/25 mutant 604162008194 Uncharacterized conserved protein [Function unknown]; Region: COG1610 604162008195 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 604162008196 Transposon insertion site of 87/7 mutant 604162008197 Transposon insertion site of 7/44 mutant 604162008198 stringent starvation protein A; Provisional; Region: sspA; PRK09481 604162008199 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 604162008200 C-terminal domain interface [polypeptide binding]; other site 604162008201 putative GSH binding site (G-site) [chemical binding]; other site 604162008202 dimer interface [polypeptide binding]; other site 604162008203 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 604162008204 dimer interface [polypeptide binding]; other site 604162008205 N-terminal domain interface [polypeptide binding]; other site 604162008206 Transposon insertion site of 80/34 mutant 604162008207 Transposon insertion site of 9/3 mutant 604162008208 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 604162008209 Transposon insertion site of 71/18 mutant 604162008210 Transposon insertion site of 32/3 mutant 604162008211 Transposon insertion site of 84/40 mutant 604162008212 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 604162008213 Cadmium resistance transporter; Region: Cad; pfam03596 604162008214 Transposon insertion site of 52/2 mutant 604162008215 Transposon insertion site of 79/34 mutant 604162008216 Transposon insertion site of 79/37 mutant 604162008217 Transposon insertion site of 73/14 mutant 604162008218 Transposon insertion site of 9/7 mutant 604162008219 Transposon insertion site of 82/18 mutant 604162008220 ribosomal protein L31; Region: L31; TIGR00105 604162008221 Transposon insertion site of 53/15 mutant 604162008222 Transposon insertion site of 54/15 mutant 604162008223 Transposon insertion site of 57/5 mutant 604162008224 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162008225 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme' 604162008226 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 604162008227 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 604162008228 catalytic residues [active] 604162008229 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 604162008230 active site 604162008231 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 604162008232 Transposon insertion site of 96/22 mutant 604162008233 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 604162008234 anti sigma factor interaction site; other site 604162008235 regulatory phosphorylation site [posttranslational modification]; other site 604162008236 Transposon insertion site of 61/13 mutant 604162008237 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 604162008238 Transposon insertion site of 57/1 mutant 604162008239 Transposon insertion site of 64/14 mutant 604162008240 Transposon insertion site of 75/16 mutant 604162008241 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 604162008242 mce related protein; Region: MCE; pfam02470 604162008243 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 604162008244 Permease; Region: Permease; pfam02405 604162008245 Transposon insertion site of 15/32 mutant 604162008246 Transposon insertion site of 54/40 mutant 604162008247 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 604162008248 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 604162008249 Walker A/P-loop; other site 604162008250 ATP binding site [chemical binding]; other site 604162008251 Q-loop/lid; other site 604162008252 ABC transporter signature motif; other site 604162008253 Walker B; other site 604162008254 D-loop; other site 604162008255 H-loop/switch region; other site 604162008256 Transposon insertion site of 5/4 mutant 604162008257 Transposon insertion site of 16/45 mutant 604162008258 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 604162008259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 604162008260 Transposon insertion site of 2160/1 mutant 604162008261 Transposon insertion site of 23/33 mutant 604162008262 Transposon insertion site of 24/24 mutant 604162008263 Transposon insertion site of 63/28 mutant 604162008264 Transposon insertion site of 39/2 mutant 604162008265 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 604162008266 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 604162008267 NAD binding site [chemical binding]; other site 604162008268 catalytic residues [active] 604162008269 substrate binding site [chemical binding]; other site 604162008270 Transposon insertion site of 91/23 mutant 604162008271 Transposon insertion site of 30/3 mutant 604162008272 Transposon insertion site of 55/46 mutant 604162008273 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme 604162008274 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme 604162008275 Transposon insertion site of 34/40 mutant 604162008276 Transposon insertion site of 82/14 mutant 604162008277 Transposon insertion site of 6/43 mutant 604162008278 Transposon insertion site of 91/37 mutant 604162008279 Transposon insertion site of 52/44 mutant 604162008280 aminodeoxychorismate synthase; Provisional; Region: PRK07508 604162008281 chorismate binding enzyme; Region: Chorismate_bind; cl10555 604162008282 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 604162008283 homodimer interface [polypeptide binding]; other site 604162008284 substrate-cofactor binding pocket; other site 604162008285 Aminotransferase class IV; Region: Aminotran_4; pfam01063 604162008286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 604162008287 catalytic residue [active] 604162008288 Transposon insertion site of 61/5 mutant 604162008289 Protein of unknown function (DUF560); Region: DUF560; pfam04575 604162008290 Transposon insertion site of 22/17 mutant 604162008291 Transposon insertion site of 40/47 mutant 604162008292 Transposon insertion site of 76/48 mutant 604162008293 Transposon insertion site of 84/43 mutant 604162008294 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162008295 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 604162008296 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 604162008297 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 604162008298 ring oligomerisation interface [polypeptide binding]; other site 604162008299 ATP/Mg binding site [chemical binding]; other site 604162008300 stacking interactions; other site 604162008301 hinge regions; other site 604162008302 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 604162008303 oligomerisation interface [polypeptide binding]; other site 604162008304 mobile loop; other site 604162008305 roof hairpin; other site 604162008306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 604162008307 Transposon insertion site of 61/28 mutant 604162008308 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 604162008309 Na2 binding site [ion binding]; other site 604162008310 putative substrate binding site 1 [chemical binding]; other site 604162008311 Na binding site 1 [ion binding]; other site 604162008312 putative substrate binding site 2 [chemical binding]; other site 604162008313 Transposon insertion site of 38/41 mutant 604162008314 Transposon insertion site of 17/17 mutant 604162008315 diaminopimelate decarboxylase; Region: lysA; TIGR01048 604162008316 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 604162008317 active site 604162008318 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 604162008319 substrate binding site [chemical binding]; other site 604162008320 catalytic residues [active] 604162008321 dimer interface [polypeptide binding]; other site 604162008322 Transposon insertion site of 67/14 mutant 604162008323 Transposon insertion site of 76/4 mutant 604162008324 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 604162008325 putative iron binding site [ion binding]; other site 604162008326 conserved hypothetical integral membrane protein; Region: TIGR00698 604162008327 Transposon insertion site of 25/22 mutant 604162008328 Transposon insertion site of 41/4 mutant 604162008329 Transposon insertion site of 71/2 mutant 604162008330 Transposon insertion site of 23/11 mutant 604162008331 Transposon insertion site of 37/7 mutant 604162008332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4316 604162008333 S-ribosylhomocysteinase; Provisional; Region: PRK02260 604162008334 DNA polymerase I; Provisional; Region: PRK05755 604162008335 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 604162008336 active site 604162008337 metal binding site 1 [ion binding]; metal-binding site 604162008338 putative 5' ssDNA interaction site; other site 604162008339 metal binding site 3; metal-binding site 604162008340 metal binding site 2 [ion binding]; metal-binding site 604162008341 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 604162008342 putative DNA binding site [nucleotide binding]; other site 604162008343 putative metal binding site [ion binding]; other site 604162008344 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 604162008345 active site 604162008346 catalytic site [active] 604162008347 substrate binding site [chemical binding]; other site 604162008348 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 604162008349 active site 604162008350 DNA binding site [nucleotide binding] 604162008351 catalytic site [active] 604162008352 Transposon insertion site of 72/2 mutant 604162008353 Transposon insertion site of 91/45 mutant 604162008354 Transposon insertion site of 57/4 mutant 604162008355 Transposon insertion site of 9/8 mutant 604162008356 Transposon insertion site of 67/45 mutant 604162008357 Transposon insertion site of 56/25 mutant 604162008358 Fic/DOC family; Region: Fic; pfam02661 604162008359 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 604162008360 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 604162008361 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 604162008362 Autotransporter beta-domain; Region: Autotransporter; pfam03797 604162008363 Transposon insertion site of 55/19 mutant 604162008364 Transposon insertion site of 27/40 mutant 604162008365 Transposon insertion site of 30/40 mutant 604162008366 Transposon insertion site of 40/31 mutant 604162008367 Transposon insertion site of 26/35 mutant 604162008368 Transposon insertion site of 2/34 mutant 604162008369 Transposon insertion site of 75/32 mutant 604162008370 Transposon insertion site of 10/2 mutant 604162008371 Transposon insertion site of 73/31 mutant 604162008372 Transposon insertion site of 40/23 mutant 604162008373 Transposon insertion site of 30/48 mutant 604162008374 Predicted membrane protein [Function unknown]; Region: COG5346 604162008375 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 604162008376 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 604162008377 trmE is a tRNA modification GTPase; Region: trmE; cd04164 604162008378 G1 box; other site 604162008379 GTP/Mg2+ binding site [chemical binding]; other site 604162008380 Switch I region; other site 604162008381 G2 box; other site 604162008382 Switch II region; other site 604162008383 G3 box; other site 604162008384 G4 box; other site 604162008385 G5 box; other site 604162008386 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 604162008387 Transposon insertion site of 36/19 mutant 604162008388 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 604162008389 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 604162008390 Transposon insertion site of 61/34 mutant 604162008391 Transposon insertion site of 24/14 mutant 604162008392 Transposon insertion site of 70/1 mutant 604162008393 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 604162008394 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 604162008395 putative ligand binding residues [chemical binding]; other site 604162008396 Transposon insertion site of 82/25 mutant 604162008397 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 604162008398 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 604162008399 ABC-ATPase subunit interface; other site 604162008400 dimer interface [polypeptide binding]; other site 604162008401 putative PBP binding regions; other site 604162008402 Transposon insertion site of 28/19 mutant 604162008403 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 604162008404 ABC-ATPase subunit interface; other site 604162008405 dimer interface [polypeptide binding]; other site 604162008406 putative PBP binding regions; other site 604162008407 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 604162008408 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 604162008409 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 604162008410 Walker A/P-loop; other site 604162008411 ATP binding site [chemical binding]; other site 604162008412 Q-loop/lid; other site 604162008413 ABC transporter signature motif; other site 604162008414 Walker B; other site 604162008415 D-loop; other site 604162008416 H-loop/switch region; other site 604162008417 YadA-like C-terminal region; Region: YadA; pfam03895 604162008418 Transposon insertion site of 59/28 mutant 604162008419 Transposon insertion site of 69/42 mutant 604162008420 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 604162008421 Nitrogen regulatory protein P-II; Region: P-II; smart00938 604162008422 Transposon insertion site of 77/43 mutant 604162008423 Transposon insertion site of 93/30 mutant 604162008424 Transposon insertion site of 14/10 mutant 604162008425 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 604162008426 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 604162008427 dimerization interface [polypeptide binding]; other site 604162008428 ATP binding site [chemical binding]; other site 604162008429 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 604162008430 dimerization interface [polypeptide binding]; other site 604162008431 ATP binding site [chemical binding]; other site 604162008432 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 604162008433 putative active site [active] 604162008434 catalytic triad [active] 604162008435 Transposon insertion site of 57/12 mutant 604162008436 Transposon insertion site of 24/10 mutant 604162008437 Transposon insertion site of 11/5 mutant 604162008438 Transposon insertion site of 4/17 mutant 604162008439 Transposon insertion site of 75/34 mutant 604162008440 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 604162008441 Transposon insertion site of 65/42 mutant 604162008442 Transposon insertion site of 71/48 mutant 604162008443 Transposon insertion site of 14/48 mutant 604162008444 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 604162008445 MgtE intracellular N domain; Region: MgtE_N; smart00924 604162008446 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 604162008447 Divalent cation transporter; Region: MgtE; pfam01769 604162008448 Transposon insertion site of 63/22 mutant 604162008449 Transposon insertion site of 66/46 mutant 604162008450 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 604162008451 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 604162008452 dimerization interface [polypeptide binding]; other site 604162008453 domain crossover interface; other site 604162008454 redox-dependent activation switch; other site 604162008455 Transposon insertion site of 12/25 mutant 604162008456 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 604162008457 NlpC/P60 family; Region: NLPC_P60; pfam00877 604162008458 Transposon insertion site of 79/5 mutant 604162008459 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 604162008460 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 604162008461 Transposon insertion site of 93/32 mutant 604162008462 Transposon insertion site of 82/42 mutant 604162008463 Transposon insertion site of 73/30 mutant 604162008464 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 604162008465 heterotetramer interface [polypeptide binding]; other site 604162008466 active site pocket [active] 604162008467 cleavage site 604162008468 Transposon insertion site of 58/24 mutant 604162008469 Transposon insertion site of 35/43 mutant 604162008470 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 604162008471 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 604162008472 putative ion selectivity filter; other site 604162008473 putative pore gating glutamate residue; other site 604162008474 putative H+/Cl- coupling transport residue; other site 604162008475 Transposon insertion site of 61/14 mutant 604162008476 Evidence 7 : Gene remnant; Product type e : enzyme 604162008477 Transposon insertion site of 44/4 mutant 604162008478 Transposon insertion site of 74/30 mutant 604162008479 HindVP restriction endonuclease; Region: RE_HindVP; pfam09519 604162008480 Transposon insertion site of 63/40 mutant 604162008481 Transposon insertion site of 52/38 mutant 604162008482 Transposon insertion site of 96/7 mutant 604162008483 Transposon insertion site of 90/3 mutant 604162008484 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 604162008485 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 604162008486 cofactor binding site; other site 604162008487 DNA binding site [nucleotide binding] 604162008488 substrate interaction site [chemical binding]; other site 604162008489 Evidence 7 : Gene remnant; Product type e : enzyme 604162008490 Transposon insertion site of 50/6 mutant 604162008491 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 604162008492 additional DNA contacts [nucleotide binding]; other site 604162008493 mismatch recognition site; other site 604162008494 active site 604162008495 zinc binding site [ion binding]; other site 604162008496 DNA intercalation site [nucleotide binding]; other site 604162008497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 604162008498 Mg2+ binding site [ion binding]; other site 604162008499 G-X-G motif; other site 604162008500 TIGR02391 family protein; Region: hypoth_ymh 604162008501 Transposon insertion site of 3/31 mutant 604162008502 Transposon insertion site of 51/7 mutant 604162008503 Transposon insertion site of 50/5 mutant 604162008504 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 604162008505 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 604162008506 cofactor binding site; other site 604162008507 DNA binding site [nucleotide binding] 604162008508 substrate interaction site [chemical binding]; other site 604162008509 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 604162008510 Evidence 7 : Gene remnant; Product type e : enzyme 604162008511 Evidence 7 : Gene remnant; Product type e : enzyme 604162008512 Transposon insertion site of 40/20 mutant 604162008513 Transposon insertion site of 47/7 mutant 604162008514 Transposon insertion site of 56/8 mutant 604162008515 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 604162008516 comEA protein; Region: comE; TIGR01259 604162008517 Helix-hairpin-helix motif; Region: HHH; pfam00633 604162008518 Transposon insertion site of 71/21 mutant 604162008519 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 604162008520 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 604162008521 active site 604162008522 Transposon insertion site of 32/2 mutant 604162008523 Transposon insertion site of 64/10 mutant 604162008524 Transposon insertion site of 13/19 mutant 604162008525 Transposon insertion site of 20/15 and 28/32 mutant 604162008526 Transposon insertion site of 6/9 mutant 604162008527 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 604162008528 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 604162008529 active site 604162008530 (T/H)XGH motif; other site 604162008531 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 604162008532 YccA-like proteins; Region: YccA_like; cd10433 604162008533 Transposon insertion site of 57/42 mutant 604162008534 Transposon insertion site of 44/5 mutant 604162008535 Transposon insertion site of 36/6 mutant 604162008536 Transposon insertion site of 76/11 mutant 604162008537 oxidative damage protection protein; Provisional; Region: PRK05408 604162008538 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 604162008539 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 604162008540 Transposon insertion site of 74/22 mutant 604162008541 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 604162008542 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 604162008543 active site 604162008544 (T/H)XGH motif; other site 604162008545 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 604162008546 active site clefts [active] 604162008547 zinc binding site [ion binding]; other site 604162008548 dimer interface [polypeptide binding]; other site 604162008549 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 604162008550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 604162008551 dimer interface [polypeptide binding]; other site 604162008552 conserved gate region; other site 604162008553 ABC-ATPase subunit interface; other site 604162008554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 604162008555 ABC-ATPase subunit interface; other site 604162008556 putative PBP binding loops; other site 604162008557 Transposon insertion site of 2/16 mutant 604162008558 Transposon insertion site of 73/41 mutant 604162008559 Transposon insertion site of 75/25 mutant 604162008560 Transposon insertion site of 5/46 mutant 604162008561 Transposon insertion site of 58/3 mutant 604162008562 Transposon insertion site of 65/31 mutant 604162008563 Transposon insertion site of 53/4 mutant 604162008564 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 604162008565 fructuronate transporter; Provisional; Region: PRK10034; cl15264 604162008566 Transposon insertion site of 10/47 mutant 604162008567 Transposon insertion site of 73/13 mutant 604162008568 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 604162008569 ATP-binding site [chemical binding]; other site 604162008570 Gluconate-6-phosphate binding site [chemical binding]; other site 604162008571 Transposon insertion site of 46/42 mutant 604162008572 Transposon insertion site of 13/17 and 79/4 mutants 604162008573 Transposon insertion site of 17/7 mutant 604162008574 Transposon insertion site of 69/8 mutant 604162008575 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 604162008576 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 604162008577 putative active site [active] 604162008578 putative substrate binding site [chemical binding]; other site 604162008579 ATP binding site [chemical binding]; other site 604162008580 Transposon insertion site of 85/9 mutant 604162008581 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 604162008582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162008583 S-adenosylmethionine binding site [chemical binding]; other site 604162008584 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 604162008585 aromatic amino acid transport protein; Region: araaP; TIGR00837 604162008586 Transposon insertion site of 60/17 mutant 604162008587 Transposon insertion site of 34/42 mutant 604162008588 Transposon insertion site of 50/8 mutant 604162008589 Transposon insertion site of 35/48 mutant 604162008590 Transposon insertion site of 4/24 mutant 604162008591 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 604162008592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 604162008593 active site 604162008594 motif I; other site 604162008595 motif II; other site 604162008596 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 604162008597 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 604162008598 putative acyl-acceptor binding pocket; other site 604162008599 Transposon insertion site of 83/16 mutant 604162008600 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 604162008601 Transposon insertion site of 92/47 mutant 604162008602 Transposon insertion site of 2/18 mutant 604162008603 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 604162008604 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 604162008605 dimerization interface 3.5A [polypeptide binding]; other site 604162008606 active site 604162008607 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 604162008608 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 604162008609 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 604162008610 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 604162008611 trimer interface [polypeptide binding]; other site 604162008612 eyelet of channel; other site 604162008613 Transposon insertion site of 5/20 mutant 604162008614 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 604162008615 ThiC-associated domain; Region: ThiC-associated; pfam13667 604162008616 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 604162008617 Transposon insertion site of 13/33 mutant 604162008618 Transposon insertion site of 84/44 mutant 604162008619 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 604162008620 nudix motif; other site 604162008621 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 604162008622 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 604162008623 Walker A/P-loop; other site 604162008624 ATP binding site [chemical binding]; other site 604162008625 Q-loop/lid; other site 604162008626 ABC transporter signature motif; other site 604162008627 Walker B; other site 604162008628 D-loop; other site 604162008629 H-loop/switch region; other site 604162008630 Transposon insertion site of 18/12 mutant 604162008631 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 604162008632 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 604162008633 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 604162008634 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 604162008635 Transposon insertion site of 46/10 mutant 604162008636 Transposon insertion site of 65/46 mutant 604162008637 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 604162008638 dimerization domain swap beta strand [polypeptide binding]; other site 604162008639 regulatory protein interface [polypeptide binding]; other site 604162008640 active site 604162008641 regulatory phosphorylation site [posttranslational modification]; other site 604162008642 Transposon insertion site of 29/24 mutant 604162008643 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 604162008644 active pocket/dimerization site; other site 604162008645 active site 604162008646 phosphorylation site [posttranslational modification] 604162008647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 604162008648 active site 604162008649 DNA ligase; Provisional; Region: PRK09125 604162008650 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 604162008651 DNA binding site [nucleotide binding] 604162008652 active site 604162008653 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 604162008654 DNA binding site [nucleotide binding] 604162008655 Transposon insertion site of 20/26 mutant 604162008656 Transposon insertion site of 21/13 mutant 604162008657 Transposon insertion site of 78/21 mutant 604162008658 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 604162008659 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 604162008660 RmuC family; Region: RmuC; pfam02646 604162008661 Transposon insertion site of 49/37 mutant 604162008662 Transposon insertion site of 45/8 mutant 604162008663 Transposon insertion site of 69/19 mutant 604162008664 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 604162008665 Transposon insertion site of 21/40 mutant 604162008666 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 604162008667 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 604162008668 Qi binding site; other site 604162008669 intrachain domain interface; other site 604162008670 interchain domain interface [polypeptide binding]; other site 604162008671 heme bH binding site [chemical binding]; other site 604162008672 heme bL binding site [chemical binding]; other site 604162008673 Qo binding site; other site 604162008674 interchain domain interface [polypeptide binding]; other site 604162008675 intrachain domain interface; other site 604162008676 Qi binding site; other site 604162008677 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 604162008678 Qo binding site; other site 604162008679 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 604162008680 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 604162008681 [2Fe-2S] cluster binding site [ion binding]; other site 604162008682 Uncharacterized conserved protein [Function unknown]; Region: COG0327 604162008683 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 604162008684 Transposon insertion site of 84/33 mutant 604162008685 Transposon insertion site of 10/9 mutant 604162008686 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 604162008687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 604162008688 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 604162008689 putative dimerization interface [polypeptide binding]; other site 604162008690 Transposon insertion site of 2258/1 mutant 604162008691 Transposon insertion site of 60/30 mutant 604162008692 Transposon insertion site of 17/29 mutant 604162008693 Transposon insertion site of 96/35 mutant 604162008694 Transposon insertion site of 46/35 mutant and 80/21 mutant 604162008695 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 604162008696 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 604162008697 23S rRNA interface [nucleotide binding]; other site 604162008698 L3 interface [polypeptide binding]; other site 604162008699 Transposon insertion site of 11/2 mutant 604162008700 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 604162008701 Transposon insertion site of 87/22 mutant 604162008702 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 604162008703 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 604162008704 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 604162008705 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 604162008706 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 604162008707 Transposon insertion site of 14/43 mutant 604162008708 Transposon insertion site of 66/47 mutant 604162008709 Transposon insertion site of 18/38 mutant 604162008710 Transposon insertion site of 41/20 mutant 604162008711 Transposon insertion site of 89/37 mutant 604162008712 Transposon insertion site of 84/2 mutant 604162008713 Transposon insertion site of 4/47 mutant 604162008714 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 604162008715 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 604162008716 ATP binding site [chemical binding]; other site 604162008717 substrate interface [chemical binding]; other site 604162008718 Transposon insertion site of 7/18 mutant 604162008719 Transposon insertion site of 71/30 mutant 604162008720 Transposon insertion site of 2/44 mutant 604162008721 Transposon insertion site of 37/31 mutant 604162008722 hypothetical protein; Provisional; Region: PRK04325 604162008723 Predicted permease [General function prediction only]; Region: COG2056 604162008724 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 604162008725 Transposon insertion site of 31/2 mutant 604162008726 Transposon insertion site of 27/5 mutant 604162008727 unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional; Region: PRK14966 604162008728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 604162008729 S-adenosylmethionine binding site [chemical binding]; other site 604162008730 Transposon insertion site of 81/39 mutant 604162008731 Transposon insertion site of 12/36 mutant 604162008732 Transposon insertion site of 36/12 mutant 604162008733 Transposon insertion site of 41/33 mutant 604162008734 Transposon insertion site of 44/20 mutant 604162008735 protease TldD; Provisional; Region: tldD; PRK10735 604162008736 Transposon insertion site of 59/45 mutant 604162008737 Transposon insertion site of 81/5 mutant 604162008738 Transposon insertion site of 77/45 mutant 604162008739 Transposon insertion site of 52/18 mutant 604162008740 Transposon insertion site of 94/3 mutant 604162008741 putative hydroxymethylpyrimidine transporter CytX; Region: thia_cytX; TIGR02358 604162008742 Na binding site [ion binding]; other site 604162008743 Transposon insertion site of 4/33 mutant 604162008744 Transposon insertion site of 84/46 mutant 604162008745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 604162008746 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 604162008747 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 604162008748 thiamine phosphate binding site [chemical binding]; other site 604162008749 active site 604162008750 pyrophosphate binding site [ion binding]; other site 604162008751 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 604162008752 thiS-thiF/thiG interaction site; other site 604162008753 Transposon insertion site of 17/41 mutant 604162008754 Transposon insertion site of 31/13 mutant 604162008755 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 604162008756 ThiS interaction site; other site 604162008757 putative active site [active] 604162008758 tetramer interface [polypeptide binding]; other site 604162008759 Transposon insertion site of 81/38 mutant 604162008760 Transposon insertion site of 6/40 mutant 604162008761 Transposon insertion site of 49/38 mutant 604162008762 Transposon insertion site of 17/20 mutant 604162008763 Transposon insertion site of 30/20 mutant 604162008764 Sporulation related domain; Region: SPOR; pfam05036 604162008765 Transposon insertion site of 60/37 mutant 604162008766 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/pantothenate kinase; Reviewed; Region: PRK13325 604162008767 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 604162008768 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 604162008769 Pantothenate kinase type III (Bvg accessory factor family protein) [Transcription]; Region: COG1521 604162008770 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 604162008771 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 604162008772 active site 604162008773 HIGH motif; other site 604162008774 nucleotide binding site [chemical binding]; other site 604162008775 Transposon insertion site of 55/48 mutant 604162008776 Transposon insertion site of 24/29 mutant 604162008777 Transposon insertion site of 53/30 mutant 604162008778 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 604162008779 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 604162008780 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 604162008781 homodimer interface [polypeptide binding]; other site 604162008782 NADP binding site [chemical binding]; other site 604162008783 substrate binding site [chemical binding]; other site 604162008784 Transposon insertion site of 73/7 mutant 604162008785 RDD family; Region: RDD; pfam06271 604162008786 Transposon insertion site of 90/40 mutant 604162008787 Transposon insertion site of 22/45 mutant 604162008788 Transposon insertion site of 39/1 mutant 604162008789 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 604162008790 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 604162008791 Transposon insertion site of 26/17 mutant 604162008792 Transposon insertion site of 46/7 mutant 604162008793 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 604162008794 putative active site [active] 604162008795 putative catalytic site [active] 604162008796 putative DNA binding site [nucleotide binding]; other site 604162008797 putative phosphate binding site [ion binding]; other site 604162008798 metal binding site A [ion binding]; metal-binding site 604162008799 putative AP binding site [nucleotide binding]; other site 604162008800 putative metal binding site B [ion binding]; other site 604162008801 Transposon insertion site of 3/30 mutant 604162008802 Transposon insertion site of 20/4 mutant 604162008803 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 604162008804 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 604162008805 active site 604162008806 HIGH motif; other site 604162008807 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 604162008808 KMSKS motif; other site 604162008809 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 604162008810 tRNA binding surface [nucleotide binding]; other site 604162008811 anticodon binding site; other site 604162008812 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 604162008813 Transposon insertion site of 51/25 mutant 604162008814 Transposon insertion site of 17/1 mutant 604162008815 Transposon insertion site of 46/45 mutant 604162008816 Transposon insertion site of 78/16 mutant 604162008817 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 604162008818 DNA methylase; Region: N6_N4_Mtase; pfam01555 604162008819 GTPase CgtA; Reviewed; Region: obgE; PRK12299 604162008820 GTP1/OBG; Region: GTP1_OBG; pfam01018 604162008821 Obg GTPase; Region: Obg; cd01898 604162008822 G1 box; other site 604162008823 GTP/Mg2+ binding site [chemical binding]; other site 604162008824 Switch I region; other site 604162008825 G2 box; other site 604162008826 G3 box; other site 604162008827 Switch II region; other site 604162008828 G4 box; other site 604162008829 G5 box; other site 604162008830 Transposon insertion site of 27/3 mutant 604162008831 Transposon insertion site of 34/10 mutant 604162008832 Transposon insertion site of 42/16 mutant 604162008833 Evidence 7 : Gene remnant; Product type pm : putative membrane component 604162008834 Predicted methyltransferases [General function prediction only]; Region: COG0313 604162008835 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 604162008836 putative SAM binding site [chemical binding]; other site 604162008837 putative homodimer interface [polypeptide binding]; other site 604162008838 Transposon insertion site of 61/19 mutant 604162008839 Transposon insertion site of 59/25 mutant 604162008840 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 604162008841 Transposon insertion site of 28/16 mutant 604162008842 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 604162008843 dimer interface [polypeptide binding]; other site 604162008844 active site 604162008845 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 604162008846 BON domain; Region: BON; pfam04972 604162008847 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 604162008848 active site 604162008849 Transposon insertion site of 67/25 mutant 604162008850 Transposon insertion site of 78/32 mutant 604162008851 Transposon insertion site of 31/23 mutant 604162008852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 604162008853 non-specific DNA binding site [nucleotide binding]; other site 604162008854 salt bridge; other site 604162008855 sequence-specific DNA binding site [nucleotide binding]; other site 604162008856 Transposon insertion site of 79/3 mutant 604162008857 Transposon insertion site of 35/11 mutant 604162008858 malate:quinone oxidoreductase; Validated; Region: PRK05257 604162008859 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 604162008860 Transposon insertion site of 90/48 mutant 604162008861 Transposon insertion site of 47/35 mutant 604162008862 Transposon insertion site of 40/44 mutant 604162008863 Transposon insertion site of 19/16 mutant 604162008864 Transposon insertion site of 17/15 mutant 604162008865 Transposon insertion site of 62/24 mutant 604162008866 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 604162008867 Transposon insertion site of 20/11 mutant 604162008868 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 604162008869 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 604162008870 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 604162008871 rRNA interaction site [nucleotide binding]; other site 604162008872 S8 interaction site; other site 604162008873 putative laminin-1 binding site; other site 604162008874 Transposon insertion site of 69/27 mutant 604162008875 elongation factor Ts; Provisional; Region: tsf; PRK09377 604162008876 UBA/TS-N domain; Region: UBA; pfam00627 604162008877 Elongation factor TS; Region: EF_TS; pfam00889 604162008878 Elongation factor TS; Region: EF_TS; pfam00889 604162008879 Transposon insertion site of 45/2 mutant 604162008880 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 604162008881 putative nucleotide binding site [chemical binding]; other site 604162008882 uridine monophosphate binding site [chemical binding]; other site 604162008883 homohexameric interface [polypeptide binding]; other site 604162008884 Transposon insertion site of 47/11 mutant 604162008885 Transposon insertion site of 45/45 mutant 604162008886 Transposon insertion site of 18/35 mutant 604162008887 Transposon insertion site of 5/25 mutant 604162008888 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 604162008889 Transposon insertion site of 13/43 mutant 604162008890 Transposon insertion site of 8/30 mutant 604162008891 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor' 604162008892 Transposon insertion site of 39/9 mutant 604162008893 Transposon insertion site of 58/25 mutant 604162008894 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor' 604162008895 Transposon insertion site of 2/32 mutant 604162008896 Transposon insertion site of 91/20 mutant 604162008897 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 604162008898 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor' 604162008899 Transposon insertion site of 41/41 mutant 604162008900 Transposon insertion site of 69/15 mutant 604162008901 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor' 604162008902 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 604162008903 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor' 604162008904 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor' 604162008905 'Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor' 604162008906 Transposon insertion site of 18/23 mutant 604162008907 Transposon insertion site of 12/13 mutant 604162008908 Transposon insertion site of 12/28 mutant 604162008909 Transposon insertion site of 30/16 mutant 604162008910 Evidence 7 : Gene remnant; Product type e : enzyme 604162008911 Transposon insertion site of 87/9 mutant 604162008912 Transposon insertion site of 61/11 mutant 604162008913 Transposon insertion site of 14/32 mutant 604162008914 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 604162008915 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 604162008916 tandem repeat interface [polypeptide binding]; other site 604162008917 oligomer interface [polypeptide binding]; other site 604162008918 active site residues [active] 604162008919 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 604162008920 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 604162008921 putative MPT binding site; other site 604162008922 Transposon insertion site of 17/31 mutant 604162008923 argininosuccinate synthase; Validated; Region: PRK05370 604162008924 argininosuccinate synthase; Provisional; Region: PRK13820 604162008925 Transposon insertion site of 24/22 mutant 604162008926 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 604162008927 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 604162008928 Transposon insertion site of 55/17 mutant 604162008929 Transposon insertion site of 93/5 mutant 604162008930 Transposon insertion site of 73/4 mutant 604162008931 serine/threonine transporter SstT; Provisional; Region: PRK13628 604162008932 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 604162008933 Transposon insertion site of 95/14 mutant 604162008934 Transposon insertion site of 13/27 mutant 604162008935 Transposon insertion site of 91/47 mutant 604162008936 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 604162008937 Surface antigen; Region: Bac_surface_Ag; pfam01103 604162008938 Transposon insertion site of 68/41 mutant 604162008939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 604162008940 Family of unknown function (DUF490); Region: DUF490; pfam04357 604162008941 Family of unknown function (DUF490); Region: DUF490; pfam04357 604162008942 Family of unknown function (DUF490); Region: DUF490; pfam04357 604162008943 Transposon insertion site of 81/9 mutant 604162008944 Transposon insertion site of 42/29 mutant 604162008945 Transposon insertion site of 73/32 mutant 604162008946 Transposon insertion site of 18/18 mutant 604162008947 Transposon insertion site of 91/31 mutant 604162008948 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 604162008949 POT family; Region: PTR2; cl17359 604162008950 Transposon insertion site of 77/44 mutant 604162008951 Transposon insertion site of 53/32 mutant 604162008952 Transposon insertion site of 11/33 mutant 604162008953 peptide chain release factor 2; Validated; Region: prfB; PRK00578 604162008954 This domain is found in peptide chain release factors; Region: PCRF; smart00937 604162008955 RF-1 domain; Region: RF-1; pfam00472 604162008956 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 604162008957 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 604162008958 active site 604162008959 nucleophile elbow; other site 604162008960 Transposon insertion site of 62/14 mutant 604162008961 Transposon insertion site of 15/9 mutant 604162008962 Transposon insertion site of 5/36 mutant 604162008963 Transposon insertion site of 17/40 mutant 604162008964 Predicted membrane protein [Function unknown]; Region: COG2259 604162008965 Transposon insertion site of 38/38 mutant 604162008966 Transposon insertion site of 43/22 mutant 604162008967 Transposon insertion site of 21/19 mutant 604162008968 Protein of unknown function (DUF692); Region: DUF692; pfam05114 604162008969 Transposon insertion site of 28/25 mutant 604162008970 Transposon insertion site of 7/3 mutant 604162008971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 604162008972 Transposon insertion site of 93/38 mutant 604162008973 Transposon insertion site of 67/12 mutant 604162008974 RNA polymerase sigma factor; Provisional; Region: PRK12532 604162008975 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 604162008976 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 604162008977 DNA binding residues [nucleotide binding] 604162008978 Transposon insertion site of 38/4 mutant 604162008979 Transposon insertion site of 82/1 mutant 604162008980 Putative zinc-finger; Region: zf-HC2; pfam13490 604162008981 Transposon insertion site of 54/20 mutant 604162008982 Transposon insertion site of 88/31 mutant 604162008983 Transposon insertion site of 23/15 mutant 604162008984 Transposon insertion site of 47/34 mutant 604162008985 Transposon insertion site of 16/20 mutant 604162008986 Transposon insertion site of 63/1 mutant 604162008987 Evidence 7 : Gene remnant; Product type e : enzyme 604162008988 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 604162008989 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 604162008990 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 604162008991 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 604162008992 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 604162008993 Transposon insertion site of 58/36 mutant 604162008994 Transposon insertion site of 15/21 mutant 604162008995 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 604162008996 Transposon insertion site of 46/44 mutant 604162008997 Transposon insertion site of 79/28 mutant 604162008998 Uncharacterized conserved protein [Function unknown]; Region: COG1739 604162008999 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 604162009000 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 604162009001 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 604162009002 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 604162009003 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 604162009004 Ligand binding site [chemical binding]; other site 604162009005 Electron transfer flavoprotein domain; Region: ETF; pfam01012 604162009006 Transposon insertion site of 50/36 mutant 604162009007 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 604162009008 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 604162009009 putative active site [active] 604162009010 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 604162009011 Isochorismatase family; Region: Isochorismatase; pfam00857 604162009012 catalytic triad [active] 604162009013 metal binding site [ion binding]; metal-binding site 604162009014 conserved cis-peptide bond; other site 604162009015 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 604162009016 homodimer interaction site [polypeptide binding]; other site 604162009017 cofactor binding site; other site 604162009018 Transposon insertion site of 20/38 mutant 604162009019 Transposon insertion site of 53/44 mutant 604162009020 Transposon insertion site of 49/14 mutant 604162009021 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 604162009022 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 604162009023 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 604162009024 Transposon insertion site of 17/47 mutant 604162009025 Transposon insertion site of 25/30 mutant 604162009026 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 604162009027 MutS domain I; Region: MutS_I; pfam01624 604162009028 MutS domain II; Region: MutS_II; pfam05188 604162009029 MutS domain III; Region: MutS_III; pfam05192 604162009030 MutS domain V; Region: MutS_V; pfam00488 604162009031 Walker A/P-loop; other site 604162009032 ATP binding site [chemical binding]; other site 604162009033 Q-loop/lid; other site 604162009034 ABC transporter signature motif; other site 604162009035 Walker B; other site 604162009036 D-loop; other site 604162009037 H-loop/switch region; other site 604162009038 Transposon insertion site of 11/16 mutant 604162009039 Transposon insertion site of 11/7 mutant 604162009040 Transposon insertion site of 51/9 mutant