-- dump date 20140619_163519 -- class Genbank::misc_feature -- table misc_feature_note -- id note 935591000001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 935591000002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935591000003 Coenzyme A binding pocket [chemical binding]; other site 935591000004 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 935591000005 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 935591000006 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 935591000007 active site 935591000008 HIGH motif; other site 935591000009 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 935591000010 active site 935591000011 KMSKS motif; other site 935591000012 Uncharacterized conserved protein [Function unknown]; Region: COG1434 935591000013 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 935591000014 putative active site [active] 935591000015 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 935591000016 ArsC family; Region: ArsC; pfam03960 935591000017 catalytic residues [active] 935591000018 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935591000019 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935591000020 catalytic residues [active] 935591000021 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 935591000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935591000023 Walker A/P-loop; other site 935591000024 ATP binding site [chemical binding]; other site 935591000025 Q-loop/lid; other site 935591000026 ABC transporter signature motif; other site 935591000027 Walker B; other site 935591000028 D-loop; other site 935591000029 H-loop/switch region; other site 935591000030 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 935591000031 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 935591000032 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 935591000033 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 935591000034 Phosphoglycerate kinase; Region: PGK; pfam00162 935591000035 substrate binding site [chemical binding]; other site 935591000036 hinge regions; other site 935591000037 ADP binding site [chemical binding]; other site 935591000038 catalytic site [active] 935591000039 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935591000040 Helix-turn-helix domain; Region: HTH_38; pfam13936 935591000041 Homeodomain-like domain; Region: HTH_32; pfam13565 935591000042 Integrase core domain; Region: rve; pfam00665 935591000043 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 935591000044 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 935591000045 hinge; other site 935591000046 active site 935591000047 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 935591000048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 935591000049 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 935591000050 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 935591000051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 935591000052 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 935591000053 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 935591000054 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 935591000055 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 935591000056 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 935591000057 Pilin (bacterial filament); Region: Pilin; pfam00114 935591000058 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935591000059 Pilin (bacterial filament); Region: Pilin; pfam00114 935591000060 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935591000061 Pilin (bacterial filament); Region: Pilin; pfam00114 935591000062 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935591000063 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935591000064 Pilin (bacterial filament); Region: Pilin; pfam00114 935591000065 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 935591000066 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935591000067 Predicted membrane protein [Function unknown]; Region: COG3205 935591000068 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 935591000069 glycerate dehydrogenase; Provisional; Region: PRK06487 935591000070 putative ligand binding site [chemical binding]; other site 935591000071 putative NAD binding site [chemical binding]; other site 935591000072 catalytic site [active] 935591000073 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 935591000074 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 935591000075 active site 935591000076 HIGH motif; other site 935591000077 KMSKS motif; other site 935591000078 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 935591000079 tRNA binding surface [nucleotide binding]; other site 935591000080 anticodon binding site; other site 935591000081 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 935591000082 dimer interface [polypeptide binding]; other site 935591000083 putative tRNA-binding site [nucleotide binding]; other site 935591000084 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 935591000085 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 935591000086 glutaminase active site [active] 935591000087 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 935591000088 dimer interface [polypeptide binding]; other site 935591000089 active site 935591000090 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 935591000091 dimer interface [polypeptide binding]; other site 935591000092 active site 935591000093 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 935591000094 MltA specific insert domain; Region: MltA; pfam03562 935591000095 3D domain; Region: 3D; pfam06725 935591000096 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 935591000097 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 935591000098 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 935591000099 Imelysin; Region: Peptidase_M75; pfam09375 935591000100 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 935591000101 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 935591000102 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 935591000103 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 935591000104 PhnA protein; Region: PhnA; pfam03831 935591000105 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 935591000106 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 935591000107 Substrate binding site; other site 935591000108 Mg++ binding site; other site 935591000109 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 935591000110 active site 935591000111 substrate binding site [chemical binding]; other site 935591000112 CoA binding site [chemical binding]; other site 935591000113 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 935591000114 ABC transporter periplasmic binding protein, thiB subfamily; Region: sfuA; TIGR01254 935591000115 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 935591000116 Conserved TM helix; Region: TM_helix; pfam05552 935591000117 Mechanosensitive ion channel; Region: MS_channel; pfam00924 935591000118 Competence-damaged protein; Region: CinA; pfam02464 935591000119 trifunctional thioredoxin/methionine sulfoxide reductase A/B protein; Provisional; Region: PRK14018 935591000120 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935591000121 catalytic residues [active] 935591000122 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 935591000123 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 935591000124 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 935591000125 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 935591000126 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 935591000127 P loop; other site 935591000128 GTP binding site [chemical binding]; other site 935591000129 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 935591000130 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 935591000131 TIGR01666 family membrane protein; Region: YCCS 935591000132 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 935591000133 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 935591000134 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 935591000135 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 935591000136 Walker A motif; other site 935591000137 ATP binding site [chemical binding]; other site 935591000138 Walker B motif; other site 935591000139 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 935591000140 SPOC domain; Region: SPOC; pfam07744 935591000141 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 935591000142 Walker A motif; other site 935591000143 ATP binding site [chemical binding]; other site 935591000144 Walker B motif; other site 935591000145 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 935591000146 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935591000147 catalytic residue [active] 935591000148 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 935591000149 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 935591000150 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 935591000151 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 935591000152 Helix-hairpin-helix motif; Region: HHH; pfam00633 935591000153 chaperone protein DnaJ; Provisional; Region: PRK10767 935591000154 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935591000155 HSP70 interaction site [polypeptide binding]; other site 935591000156 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 935591000157 substrate binding site [polypeptide binding]; other site 935591000158 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 935591000159 Zn binding sites [ion binding]; other site 935591000160 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 935591000161 dimer interface [polypeptide binding]; other site 935591000162 Predicted membrane protein [Function unknown]; Region: COG1297 935591000163 putative oligopeptide transporter, OPT family; Region: TIGR00733 935591000164 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 935591000165 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 935591000166 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 935591000167 substrate binding site; other site 935591000168 tetramer interface; other site 935591000169 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 935591000170 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 935591000171 NAD binding site [chemical binding]; other site 935591000172 substrate binding site [chemical binding]; other site 935591000173 homodimer interface [polypeptide binding]; other site 935591000174 active site 935591000175 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 935591000176 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 935591000177 NAD binding site [chemical binding]; other site 935591000178 homodimer interface [polypeptide binding]; other site 935591000179 active site 935591000180 substrate binding site [chemical binding]; other site 935591000181 Transposase domain (DUF772); Region: DUF772; pfam05598 935591000182 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591000183 DDE superfamily endonuclease; Region: DDE_4; cl17710 935591000184 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 935591000185 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 935591000186 NeuB family; Region: NeuB; pfam03102 935591000187 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 935591000188 NeuB binding interface [polypeptide binding]; other site 935591000189 putative substrate binding site [chemical binding]; other site 935591000190 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 935591000191 ligand binding site; other site 935591000192 tetramer interface; other site 935591000193 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 935591000194 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 935591000195 active site 935591000196 homodimer interface [polypeptide binding]; other site 935591000197 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 935591000198 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 935591000199 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 935591000200 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 935591000201 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 935591000202 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 935591000203 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 935591000204 Walker A/P-loop; other site 935591000205 ATP binding site [chemical binding]; other site 935591000206 Q-loop/lid; other site 935591000207 ABC transporter signature motif; other site 935591000208 Walker B; other site 935591000209 D-loop; other site 935591000210 H-loop/switch region; other site 935591000211 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 935591000212 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 935591000213 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 935591000214 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 935591000215 RNA binding site [nucleotide binding]; other site 935591000216 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 935591000217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935591000218 active site 935591000219 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 935591000220 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 935591000221 NAD binding site [chemical binding]; other site 935591000222 substrate binding site [chemical binding]; other site 935591000223 homodimer interface [polypeptide binding]; other site 935591000224 active site 935591000225 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 935591000226 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 935591000227 substrate binding site; other site 935591000228 tetramer interface; other site 935591000229 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 935591000230 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 935591000231 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 935591000232 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 935591000233 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935591000234 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935591000235 Sel1-like repeats; Region: SEL1; smart00671 935591000236 Sel1-like repeats; Region: SEL1; smart00671 935591000237 Sel1-like repeats; Region: SEL1; smart00671 935591000238 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 935591000239 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 935591000240 cyanate hydratase; Validated; Region: PRK02866 935591000241 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 935591000242 pyruvate kinase; Provisional; Region: PRK05826 935591000243 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 935591000244 domain interfaces; other site 935591000245 active site 935591000246 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 935591000247 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935591000248 HlyD family secretion protein; Region: HlyD_3; pfam13437 935591000249 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 935591000250 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 935591000251 putative active site [active] 935591000252 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935591000253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935591000254 Walker A/P-loop; other site 935591000255 ATP binding site [chemical binding]; other site 935591000256 Q-loop/lid; other site 935591000257 ABC transporter signature motif; other site 935591000258 Walker B; other site 935591000259 D-loop; other site 935591000260 H-loop/switch region; other site 935591000261 GTPase CgtA; Reviewed; Region: obgE; PRK12299 935591000262 GTP1/OBG; Region: GTP1_OBG; pfam01018 935591000263 Obg GTPase; Region: Obg; cd01898 935591000264 G1 box; other site 935591000265 GTP/Mg2+ binding site [chemical binding]; other site 935591000266 Switch I region; other site 935591000267 G2 box; other site 935591000268 G3 box; other site 935591000269 Switch II region; other site 935591000270 G4 box; other site 935591000271 G5 box; other site 935591000272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935591000273 AAA domain; Region: AAA_21; pfam13304 935591000274 Walker A/P-loop; other site 935591000275 ATP binding site [chemical binding]; other site 935591000276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935591000277 ABC transporter signature motif; other site 935591000278 Walker B; other site 935591000279 D-loop; other site 935591000280 H-loop/switch region; other site 935591000281 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 935591000282 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 935591000283 active site 935591000284 HIGH motif; other site 935591000285 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 935591000286 KMSKS motif; other site 935591000287 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 935591000288 tRNA binding surface [nucleotide binding]; other site 935591000289 anticodon binding site; other site 935591000290 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 935591000291 putative active site [active] 935591000292 putative catalytic site [active] 935591000293 putative DNA binding site [nucleotide binding]; other site 935591000294 putative phosphate binding site [ion binding]; other site 935591000295 metal binding site A [ion binding]; metal-binding site 935591000296 putative AP binding site [nucleotide binding]; other site 935591000297 putative metal binding site B [ion binding]; other site 935591000298 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 935591000299 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 935591000300 RDD family; Region: RDD; pfam06271 935591000301 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 935591000302 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 935591000303 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 935591000304 homodimer interface [polypeptide binding]; other site 935591000305 NADP binding site [chemical binding]; other site 935591000306 substrate binding site [chemical binding]; other site 935591000307 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 935591000308 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 935591000309 active site 935591000310 HIGH motif; other site 935591000311 nucleotide binding site [chemical binding]; other site 935591000312 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/pantothenate kinase; Reviewed; Region: PRK13325 935591000313 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 935591000314 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 935591000315 Pantothenate kinase type III (Bvg accessory factor family protein) [Transcription]; Region: COG1521 935591000316 Sporulation related domain; Region: SPOR; pfam05036 935591000317 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 935591000318 ThiS interaction site; other site 935591000319 putative active site [active] 935591000320 tetramer interface [polypeptide binding]; other site 935591000321 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 935591000322 thiS-thiF/thiG interaction site; other site 935591000323 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 935591000324 thiamine phosphate binding site [chemical binding]; other site 935591000325 active site 935591000326 pyrophosphate binding site [ion binding]; other site 935591000327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935591000328 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 935591000329 putative hydroxymethylpyrimidine transporter CytX; Region: thia_cytX; TIGR02358 935591000330 Na binding site [ion binding]; other site 935591000331 protease TldD; Provisional; Region: tldD; PRK10735 935591000332 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 935591000333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591000334 S-adenosylmethionine binding site [chemical binding]; other site 935591000335 Predicted permease [General function prediction only]; Region: COG2056 935591000336 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 935591000337 hypothetical protein; Provisional; Region: PRK04325 935591000338 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 935591000339 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 935591000340 ATP binding site [chemical binding]; other site 935591000341 substrate interface [chemical binding]; other site 935591000342 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 935591000343 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 935591000344 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 935591000345 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 935591000346 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 935591000347 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 935591000348 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 935591000349 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 935591000350 23S rRNA interface [nucleotide binding]; other site 935591000351 L3 interface [polypeptide binding]; other site 935591000352 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 935591000353 Transposase domain (DUF772); Region: DUF772; pfam05598 935591000354 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591000355 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935591000356 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 935591000357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935591000358 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 935591000359 putative dimerization interface [polypeptide binding]; other site 935591000360 Uncharacterized conserved protein [Function unknown]; Region: COG0327 935591000361 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 935591000362 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 935591000363 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 935591000364 [2Fe-2S] cluster binding site [ion binding]; other site 935591000365 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 935591000366 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 935591000367 Qi binding site; other site 935591000368 intrachain domain interface; other site 935591000369 interchain domain interface [polypeptide binding]; other site 935591000370 heme bH binding site [chemical binding]; other site 935591000371 heme bL binding site [chemical binding]; other site 935591000372 Qo binding site; other site 935591000373 interchain domain interface [polypeptide binding]; other site 935591000374 intrachain domain interface; other site 935591000375 Qi binding site; other site 935591000376 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 935591000377 Qo binding site; other site 935591000378 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 935591000379 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 935591000380 RmuC family; Region: RmuC; pfam02646 935591000381 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 935591000382 DNA ligase; Provisional; Region: PRK09125 935591000383 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 935591000384 DNA binding site [nucleotide binding] 935591000385 active site 935591000386 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 935591000387 DNA binding site [nucleotide binding] 935591000388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935591000389 active site 935591000390 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 935591000391 active pocket/dimerization site; other site 935591000392 active site 935591000393 phosphorylation site [posttranslational modification] 935591000394 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 935591000395 dimerization domain swap beta strand [polypeptide binding]; other site 935591000396 regulatory protein interface [polypeptide binding]; other site 935591000397 active site 935591000398 regulatory phosphorylation site [posttranslational modification]; other site 935591000399 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 935591000400 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 935591000401 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 935591000402 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 935591000403 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 935591000404 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 935591000405 Walker A/P-loop; other site 935591000406 ATP binding site [chemical binding]; other site 935591000407 Q-loop/lid; other site 935591000408 ABC transporter signature motif; other site 935591000409 Walker B; other site 935591000410 D-loop; other site 935591000411 H-loop/switch region; other site 935591000412 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 935591000413 nudix motif; other site 935591000414 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 935591000415 ThiC-associated domain; Region: ThiC-associated; pfam13667 935591000416 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 935591000417 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 935591000418 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 935591000419 trimer interface [polypeptide binding]; other site 935591000420 eyelet of channel; other site 935591000421 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 935591000422 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 935591000423 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 935591000424 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 935591000425 dimerization interface 3.5A [polypeptide binding]; other site 935591000426 active site 935591000427 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 935591000428 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 935591000429 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 935591000430 putative acyl-acceptor binding pocket; other site 935591000431 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 935591000432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935591000433 active site 935591000434 motif I; other site 935591000435 motif II; other site 935591000436 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 935591000437 aromatic amino acid transport protein; Region: araaP; TIGR00837 935591000438 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 935591000439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591000440 S-adenosylmethionine binding site [chemical binding]; other site 935591000441 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 935591000442 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 935591000443 putative active site [active] 935591000444 putative substrate binding site [chemical binding]; other site 935591000445 ATP binding site [chemical binding]; other site 935591000446 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 935591000447 ATP-binding site [chemical binding]; other site 935591000448 Gluconate-6-phosphate binding site [chemical binding]; other site 935591000449 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 935591000450 fructuronate transporter; Provisional; Region: PRK10034; cl15264 935591000451 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 935591000452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935591000453 dimer interface [polypeptide binding]; other site 935591000454 conserved gate region; other site 935591000455 ABC-ATPase subunit interface; other site 935591000456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935591000457 dimer interface [polypeptide binding]; other site 935591000458 ABC-ATPase subunit interface; other site 935591000459 putative PBP binding loops; other site 935591000460 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 935591000461 active site clefts [active] 935591000462 zinc binding site [ion binding]; other site 935591000463 dimer interface [polypeptide binding]; other site 935591000464 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 935591000465 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 935591000466 active site 935591000467 (T/H)XGH motif; other site 935591000468 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 935591000469 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 935591000470 oxidative damage protection protein; Provisional; Region: PRK05408 935591000471 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 935591000472 YccA-like proteins; Region: YccA_like; cd10433 935591000473 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 935591000474 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 935591000475 active site 935591000476 (T/H)XGH motif; other site 935591000477 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 935591000478 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 935591000479 active site 935591000480 comEA protein; Region: comE; TIGR01259 935591000481 Helix-hairpin-helix motif; Region: HHH; pfam00633 935591000482 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 935591000483 Transposase domain (DUF772); Region: DUF772; pfam05598 935591000484 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591000485 ScaI restriction endonuclease; Region: RE_ScaI; pfam09569 935591000486 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 935591000487 DNA methylase; Region: N6_N4_Mtase; pfam01555 935591000488 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 935591000489 Helicase associated domain (HA2); Region: HA2; pfam04408 935591000490 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 935591000491 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 935591000492 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 935591000493 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 935591000494 Sulfatase; Region: Sulfatase; pfam00884 935591000495 DEAD-like helicases superfamily; Region: DEXDc; smart00487 935591000496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935591000497 ATP binding site [chemical binding]; other site 935591000498 putative Mg++ binding site [ion binding]; other site 935591000499 nucleotide binding region [chemical binding]; other site 935591000500 helicase superfamily c-terminal domain; Region: HELICc; smart00490 935591000501 ATP-binding site [chemical binding]; other site 935591000502 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 935591000503 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 935591000504 putative ion selectivity filter; other site 935591000505 putative pore gating glutamate residue; other site 935591000506 putative H+/Cl- coupling transport residue; other site 935591000507 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 935591000508 heterotetramer interface [polypeptide binding]; other site 935591000509 active site pocket [active] 935591000510 cleavage site 935591000511 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 935591000512 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 935591000513 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 935591000514 NlpC/P60 family; Region: NLPC_P60; pfam00877 935591000515 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 935591000516 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 935591000517 dimerization interface [polypeptide binding]; other site 935591000518 domain crossover interface; other site 935591000519 redox-dependent activation switch; other site 935591000520 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 935591000521 MgtE intracellular N domain; Region: MgtE_N; smart00924 935591000522 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 935591000523 Divalent cation transporter; Region: MgtE; pfam01769 935591000524 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 935591000525 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 935591000526 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 935591000527 Autotransporter beta-domain; Region: Autotransporter; pfam03797 935591000528 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 935591000529 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 935591000530 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 935591000531 dimerization interface [polypeptide binding]; other site 935591000532 ATP binding site [chemical binding]; other site 935591000533 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 935591000534 dimerization interface [polypeptide binding]; other site 935591000535 ATP binding site [chemical binding]; other site 935591000536 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 935591000537 putative active site [active] 935591000538 catalytic triad [active] 935591000539 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 935591000540 Nitrogen regulatory protein P-II; Region: P-II; smart00938 935591000541 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 935591000542 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935591000543 Walker A/P-loop; other site 935591000544 ATP binding site [chemical binding]; other site 935591000545 Q-loop/lid; other site 935591000546 ABC transporter signature motif; other site 935591000547 Walker B; other site 935591000548 D-loop; other site 935591000549 H-loop/switch region; other site 935591000550 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 935591000551 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935591000552 ABC-ATPase subunit interface; other site 935591000553 dimer interface [polypeptide binding]; other site 935591000554 putative PBP binding regions; other site 935591000555 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 935591000556 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935591000557 ABC-ATPase subunit interface; other site 935591000558 dimer interface [polypeptide binding]; other site 935591000559 putative PBP binding regions; other site 935591000560 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 935591000561 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 935591000562 putative ligand binding residues [chemical binding]; other site 935591000563 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935591000564 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 935591000565 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 935591000566 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 935591000567 trmE is a tRNA modification GTPase; Region: trmE; cd04164 935591000568 G1 box; other site 935591000569 GTP/Mg2+ binding site [chemical binding]; other site 935591000570 Switch I region; other site 935591000571 G2 box; other site 935591000572 Switch II region; other site 935591000573 G3 box; other site 935591000574 G4 box; other site 935591000575 G5 box; other site 935591000576 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 935591000577 Predicted membrane protein [Function unknown]; Region: COG5346 935591000578 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 935591000579 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 935591000580 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 935591000581 Autotransporter beta-domain; Region: Autotransporter; pfam03797 935591000582 Transposase domain (DUF772); Region: DUF772; pfam05598 935591000583 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591000584 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935591000585 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935591000586 Fic/DOC family; Region: Fic; pfam02661 935591000587 DNA polymerase I; Provisional; Region: PRK05755 935591000588 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 935591000589 active site 935591000590 metal binding site 1 [ion binding]; metal-binding site 935591000591 putative 5' ssDNA interaction site; other site 935591000592 metal binding site 3; metal-binding site 935591000593 metal binding site 2 [ion binding]; metal-binding site 935591000594 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 935591000595 putative DNA binding site [nucleotide binding]; other site 935591000596 putative metal binding site [ion binding]; other site 935591000597 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 935591000598 active site 935591000599 catalytic site [active] 935591000600 substrate binding site [chemical binding]; other site 935591000601 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 935591000602 active site 935591000603 DNA binding site [nucleotide binding] 935591000604 catalytic site [active] 935591000605 S-ribosylhomocysteinase; Provisional; Region: PRK02260 935591000606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4316 935591000607 conserved hypothetical integral membrane protein; Region: TIGR00698 935591000608 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 935591000609 putative iron binding site [ion binding]; other site 935591000610 diaminopimelate decarboxylase; Region: lysA; TIGR01048 935591000611 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 935591000612 active site 935591000613 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935591000614 substrate binding site [chemical binding]; other site 935591000615 catalytic residues [active] 935591000616 dimer interface [polypeptide binding]; other site 935591000617 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 935591000618 Na2 binding site [ion binding]; other site 935591000619 putative substrate binding site 1 [chemical binding]; other site 935591000620 Na binding site 1 [ion binding]; other site 935591000621 putative substrate binding site 2 [chemical binding]; other site 935591000622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935591000623 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 935591000624 oligomerisation interface [polypeptide binding]; other site 935591000625 mobile loop; other site 935591000626 roof hairpin; other site 935591000627 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 935591000628 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 935591000629 ring oligomerisation interface [polypeptide binding]; other site 935591000630 ATP/Mg binding site [chemical binding]; other site 935591000631 stacking interactions; other site 935591000632 hinge regions; other site 935591000633 Transposase domain (DUF772); Region: DUF772; pfam05598 935591000634 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591000635 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935591000636 Protein of unknown function (DUF560); Region: DUF560; pfam04575 935591000637 aminodeoxychorismate synthase; Provisional; Region: PRK07508 935591000638 chorismate binding enzyme; Region: Chorismate_bind; cl10555 935591000639 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 935591000640 homodimer interface [polypeptide binding]; other site 935591000641 substrate-cofactor binding pocket; other site 935591000642 Aminotransferase class IV; Region: Aminotran_4; pfam01063 935591000643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591000644 catalytic residue [active] 935591000645 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 935591000646 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 935591000647 NAD binding site [chemical binding]; other site 935591000648 catalytic residues [active] 935591000649 substrate binding site [chemical binding]; other site 935591000650 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 935591000651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 935591000652 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 935591000653 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 935591000654 Walker A/P-loop; other site 935591000655 ATP binding site [chemical binding]; other site 935591000656 Q-loop/lid; other site 935591000657 ABC transporter signature motif; other site 935591000658 Walker B; other site 935591000659 D-loop; other site 935591000660 H-loop/switch region; other site 935591000661 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 935591000662 Permease; Region: Permease; pfam02405 935591000663 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 935591000664 mce related protein; Region: MCE; pfam02470 935591000665 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 935591000666 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 935591000667 anti sigma factor interaction site; other site 935591000668 regulatory phosphorylation site [posttranslational modification]; other site 935591000669 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 935591000670 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 935591000671 active site 935591000672 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935591000673 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935591000674 catalytic residues [active] 935591000675 ribosomal protein L31; Region: L31; TIGR00105 935591000676 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 935591000677 Cadmium resistance transporter; Region: Cad; pfam03596 935591000678 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 935591000679 stringent starvation protein A; Provisional; Region: sspA; PRK09481 935591000680 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 935591000681 C-terminal domain interface [polypeptide binding]; other site 935591000682 putative GSH binding site (G-site) [chemical binding]; other site 935591000683 dimer interface [polypeptide binding]; other site 935591000684 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 935591000685 dimer interface [polypeptide binding]; other site 935591000686 N-terminal domain interface [polypeptide binding]; other site 935591000687 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 935591000688 Uncharacterized conserved protein [Function unknown]; Region: COG1610 935591000689 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 935591000690 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 935591000691 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935591000692 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935591000693 catalytic residue [active] 935591000694 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 935591000695 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 935591000696 Walker A/P-loop; other site 935591000697 ATP binding site [chemical binding]; other site 935591000698 Q-loop/lid; other site 935591000699 ABC transporter signature motif; other site 935591000700 Walker B; other site 935591000701 D-loop; other site 935591000702 H-loop/switch region; other site 935591000703 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 935591000704 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 935591000705 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 935591000706 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 935591000707 Flavoprotein; Region: Flavoprotein; pfam02441 935591000708 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 935591000709 ParB-like nuclease domain; Region: ParBc; pfam02195 935591000710 KorB domain; Region: KorB; pfam08535 935591000711 F0F1-type ATP synthase, subunit I [Energy production and conversion]; Region: AtpI; COG3312 935591000712 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 935591000713 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 935591000714 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 935591000715 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 935591000716 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 935591000717 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 935591000718 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 935591000719 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 935591000720 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 935591000721 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 935591000722 beta subunit interaction interface [polypeptide binding]; other site 935591000723 Walker A motif; other site 935591000724 ATP binding site [chemical binding]; other site 935591000725 Walker B motif; other site 935591000726 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 935591000727 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 935591000728 core domain interface [polypeptide binding]; other site 935591000729 delta subunit interface [polypeptide binding]; other site 935591000730 epsilon subunit interface [polypeptide binding]; other site 935591000731 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 935591000732 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 935591000733 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 935591000734 alpha subunit interaction interface [polypeptide binding]; other site 935591000735 Walker A motif; other site 935591000736 ATP binding site [chemical binding]; other site 935591000737 Walker B motif; other site 935591000738 inhibitor binding site; inhibition site 935591000739 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 935591000740 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 935591000741 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 935591000742 gamma subunit interface [polypeptide binding]; other site 935591000743 epsilon subunit interface [polypeptide binding]; other site 935591000744 LBP interface [polypeptide binding]; other site 935591000745 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 935591000746 dimer interface [polypeptide binding]; other site 935591000747 motif 1; other site 935591000748 active site 935591000749 motif 2; other site 935591000750 motif 3; other site 935591000751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3171 935591000752 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 935591000753 DALR anticodon binding domain; Region: DALR_1; pfam05746 935591000754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 935591000755 active site 935591000756 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 935591000757 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 935591000758 Ligand binding site; other site 935591000759 metal-binding site 935591000760 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 935591000761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 935591000762 active site 935591000763 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 935591000764 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 935591000765 RNA methyltransferase, RsmE family; Region: TIGR00046 935591000766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 935591000767 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 935591000768 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935591000769 active site 935591000770 hypothetical protein; Provisional; Region: PRK01752 935591000771 SEC-C motif; Region: SEC-C; pfam02810 935591000772 Transposase domain (DUF772); Region: DUF772; pfam05598 935591000773 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591000774 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935591000775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 935591000776 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591000777 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935591000778 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 935591000779 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 935591000780 NAD(P) binding site [chemical binding]; other site 935591000781 homotetramer interface [polypeptide binding]; other site 935591000782 homodimer interface [polypeptide binding]; other site 935591000783 active site 935591000784 GMP synthase; Reviewed; Region: guaA; PRK00074 935591000785 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 935591000786 AMP/PPi binding site [chemical binding]; other site 935591000787 candidate oxyanion hole; other site 935591000788 catalytic triad [active] 935591000789 potential glutamine specificity residues [chemical binding]; other site 935591000790 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 935591000791 ATP Binding subdomain [chemical binding]; other site 935591000792 Ligand Binding sites [chemical binding]; other site 935591000793 Dimerization subdomain; other site 935591000794 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 935591000795 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935591000796 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 935591000797 Walker A/P-loop; other site 935591000798 ATP binding site [chemical binding]; other site 935591000799 Q-loop/lid; other site 935591000800 ABC transporter signature motif; other site 935591000801 Walker B; other site 935591000802 D-loop; other site 935591000803 H-loop/switch region; other site 935591000804 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 935591000805 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 935591000806 Predicted membrane protein [Function unknown]; Region: COG3326 935591000807 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 935591000808 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 935591000809 dimer interface [polypeptide binding]; other site 935591000810 active site 935591000811 CoA binding pocket [chemical binding]; other site 935591000812 putative phosphate acyltransferase; Provisional; Region: PRK05331 935591000813 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 935591000814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935591000815 active site 935591000816 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 935591000817 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 935591000818 Maf-like protein; Region: Maf; pfam02545 935591000819 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 935591000820 active site 935591000821 dimer interface [polypeptide binding]; other site 935591000822 Predicted methyltransferases [General function prediction only]; Region: COG0313 935591000823 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 935591000824 putative SAM binding site [chemical binding]; other site 935591000825 homodimer interface [polypeptide binding]; other site 935591000826 membrane protein insertase; Provisional; Region: PRK01318 935591000827 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 935591000828 hypothetical protein; Provisional; Region: PRK14373 935591000829 ribonuclease P; Reviewed; Region: rnpA; PRK04390 935591000830 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 935591000831 DnaA N-terminal domain; Region: DnaA_N; pfam11638 935591000832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591000833 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 935591000834 Walker A motif; other site 935591000835 ATP binding site [chemical binding]; other site 935591000836 Walker B motif; other site 935591000837 arginine finger; other site 935591000838 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 935591000839 DnaA box-binding interface [nucleotide binding]; other site 935591000840 DNA polymerase III subunit beta; Validated; Region: PRK05643 935591000841 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 935591000842 putative DNA binding surface [nucleotide binding]; other site 935591000843 dimer interface [polypeptide binding]; other site 935591000844 beta-clamp/clamp loader binding surface; other site 935591000845 beta-clamp/translesion DNA polymerase binding surface; other site 935591000846 polyphosphate kinase; Provisional; Region: PRK05443 935591000847 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 935591000848 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 935591000849 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 935591000850 putative domain interface [polypeptide binding]; other site 935591000851 putative active site [active] 935591000852 catalytic site [active] 935591000853 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 935591000854 putative domain interface [polypeptide binding]; other site 935591000855 putative active site [active] 935591000856 catalytic site [active] 935591000857 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 935591000858 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 935591000859 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 935591000860 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 935591000861 HIGH motif; other site 935591000862 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 935591000863 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935591000864 active site 935591000865 KMSKS motif; other site 935591000866 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 935591000867 tRNA binding surface [nucleotide binding]; other site 935591000868 Dam-replacing family; Region: DRP; pfam06044 935591000869 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 935591000870 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 935591000871 Predicted transcriptional regulator [Transcription]; Region: COG2944 935591000872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935591000873 non-specific DNA binding site [nucleotide binding]; other site 935591000874 salt bridge; other site 935591000875 sequence-specific DNA binding site [nucleotide binding]; other site 935591000876 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 935591000877 triosephosphate isomerase; Provisional; Region: PRK14567 935591000878 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 935591000879 substrate binding site [chemical binding]; other site 935591000880 dimer interface [polypeptide binding]; other site 935591000881 catalytic triad [active] 935591000882 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 935591000883 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 935591000884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591000885 S-adenosylmethionine binding site [chemical binding]; other site 935591000886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 935591000887 active site residue [active] 935591000888 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 935591000889 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935591000890 N-terminal plug; other site 935591000891 ligand-binding site [chemical binding]; other site 935591000892 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 935591000893 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 935591000894 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 935591000895 putative ligand binding residues [chemical binding]; other site 935591000896 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 935591000897 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 935591000898 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 935591000899 amino-acid N-acetyltransferase; Region: N-Ac-Glu-synth; TIGR01890 935591000900 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 935591000901 putative feedback inhibition sensing region; other site 935591000902 putative nucleotide binding site [chemical binding]; other site 935591000903 putative substrate binding site [chemical binding]; other site 935591000904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935591000905 Coenzyme A binding pocket [chemical binding]; other site 935591000906 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 935591000907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935591000908 active site 935591000909 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 935591000910 active site 935591000911 Fe-S cluster binding site [ion binding]; other site 935591000912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935591000913 Coenzyme A binding pocket [chemical binding]; other site 935591000914 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 935591000915 Glycoprotease family; Region: Peptidase_M22; pfam00814 935591000916 Lipoprotein GNA1870 C terminal like; Region: Lipoprot_C; pfam08794 935591000917 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 935591000918 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 935591000919 intersubunit interface [polypeptide binding]; other site 935591000920 active site 935591000921 zinc binding site [ion binding]; other site 935591000922 Na+ binding site [ion binding]; other site 935591000923 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 935591000924 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 935591000925 active site 935591000926 Int/Topo IB signature motif; other site 935591000927 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 935591000928 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 935591000929 TPP-binding site; other site 935591000930 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 935591000931 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 935591000932 PYR/PP interface [polypeptide binding]; other site 935591000933 dimer interface [polypeptide binding]; other site 935591000934 TPP binding site [chemical binding]; other site 935591000935 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 935591000936 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 935591000937 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 935591000938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935591000939 FeS/SAM binding site; other site 935591000940 TRAM domain; Region: TRAM; pfam01938 935591000941 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 935591000942 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935591000943 inhibitor-cofactor binding pocket; inhibition site 935591000944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591000945 catalytic residue [active] 935591000946 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 935591000947 catalytic site [active] 935591000948 putative active site [active] 935591000949 putative substrate binding site [chemical binding]; other site 935591000950 dimer interface [polypeptide binding]; other site 935591000951 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 935591000952 DNA methylase; Region: N6_N4_Mtase; cl17433 935591000953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591000954 S-adenosylmethionine binding site [chemical binding]; other site 935591000955 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 935591000956 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935591000957 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 935591000958 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 935591000959 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 935591000960 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 935591000961 carboxyltransferase (CT) interaction site; other site 935591000962 biotinylation site [posttranslational modification]; other site 935591000963 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 935591000964 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 935591000965 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 935591000966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935591000967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935591000968 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 935591000969 putative effector binding pocket; other site 935591000970 dimerization interface [polypeptide binding]; other site 935591000971 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 935591000972 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935591000973 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 935591000974 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 935591000975 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935591000976 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935591000977 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 935591000978 IMP binding site; other site 935591000979 dimer interface [polypeptide binding]; other site 935591000980 interdomain contacts; other site 935591000981 partial ornithine binding site; other site 935591000982 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 935591000983 putative active site [active] 935591000984 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 935591000985 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935591000986 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 935591000987 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 935591000988 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 935591000989 catalytic site [active] 935591000990 subunit interface [polypeptide binding]; other site 935591000991 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 935591000992 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 935591000993 antiporter inner membrane protein; Provisional; Region: PRK11670 935591000994 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 935591000995 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 935591000996 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935591000997 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 935591000998 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 935591000999 4-hydroxyphenylacetate 3-monooxygenase, reductase component; Region: HpaC; TIGR02296 935591001000 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 935591001001 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 935591001002 Substrate binding site; other site 935591001003 metal-binding site 935591001004 Predicted membrane protein [Function unknown]; Region: COG2510 935591001005 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 935591001006 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 935591001007 Potassium binding sites [ion binding]; other site 935591001008 Cesium cation binding sites [ion binding]; other site 935591001009 GTP-binding protein YchF; Reviewed; Region: PRK09601 935591001010 YchF GTPase; Region: YchF; cd01900 935591001011 G1 box; other site 935591001012 GTP/Mg2+ binding site [chemical binding]; other site 935591001013 Switch I region; other site 935591001014 G2 box; other site 935591001015 Switch II region; other site 935591001016 G3 box; other site 935591001017 G4 box; other site 935591001018 G5 box; other site 935591001019 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 935591001020 Transposase domain (DUF772); Region: DUF772; pfam05598 935591001021 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591001022 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935591001023 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 935591001024 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 935591001025 active site 935591001026 HIGH motif; other site 935591001027 dimer interface [polypeptide binding]; other site 935591001028 KMSKS motif; other site 935591001029 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 935591001030 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 935591001031 active site 935591001032 Riboflavin kinase; Region: Flavokinase; smart00904 935591001033 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 935591001034 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935591001035 active site 935591001036 HIGH motif; other site 935591001037 nucleotide binding site [chemical binding]; other site 935591001038 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 935591001039 active site 935591001040 KMSKS motif; other site 935591001041 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 935591001042 tRNA binding surface [nucleotide binding]; other site 935591001043 anticodon binding site; other site 935591001044 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 935591001045 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 935591001046 lipoprotein signal peptidase; Provisional; Region: PRK14787 935591001047 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 935591001048 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 935591001049 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 935591001050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935591001051 motif II; other site 935591001052 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 935591001053 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 935591001054 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935591001055 N-terminal plug; other site 935591001056 ligand-binding site [chemical binding]; other site 935591001057 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 935591001058 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 935591001059 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 935591001060 putative active site [active] 935591001061 putative PHP Thumb interface [polypeptide binding]; other site 935591001062 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 935591001063 generic binding surface II; other site 935591001064 generic binding surface I; other site 935591001065 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935591001066 RNA binding surface [nucleotide binding]; other site 935591001067 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 935591001068 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 935591001069 active site 935591001070 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 935591001071 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and metabolism]; Region: COG3977 935591001072 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935591001073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591001074 homodimer interface [polypeptide binding]; other site 935591001075 catalytic residue [active] 935591001076 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 935591001077 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 935591001078 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 935591001079 NAD(P) binding site [chemical binding]; other site 935591001080 homodimer interface [polypeptide binding]; other site 935591001081 substrate binding site [chemical binding]; other site 935591001082 active site 935591001083 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 935591001084 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 935591001085 inhibitor-cofactor binding pocket; inhibition site 935591001086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591001087 catalytic residue [active] 935591001088 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 935591001089 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 935591001090 Bacterial sugar transferase; Region: Bac_transf; pfam02397 935591001091 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 935591001092 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935591001093 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 935591001094 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 935591001095 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 935591001096 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 935591001097 catalytic motif [active] 935591001098 Zn binding site [ion binding]; other site 935591001099 RibD C-terminal domain; Region: RibD_C; cl17279 935591001100 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 935591001101 ATP cone domain; Region: ATP-cone; pfam03477 935591001102 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 935591001103 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 935591001104 putative dimer interface [polypeptide binding]; other site 935591001105 putative active site [active] 935591001106 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 935591001107 active site 935591001108 dimer interface [polypeptide binding]; other site 935591001109 metal binding site [ion binding]; metal-binding site 935591001110 shikimate kinase; Reviewed; Region: aroK; PRK00131 935591001111 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 935591001112 ADP binding site [chemical binding]; other site 935591001113 magnesium binding site [ion binding]; other site 935591001114 putative shikimate binding site; other site 935591001115 AMIN domain; Region: AMIN; pfam11741 935591001116 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 935591001117 Secretin and TonB N terminus short domain; Region: STN; pfam07660 935591001118 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 935591001119 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 935591001120 Pilus assembly protein, PilP; Region: PilP; pfam04351 935591001121 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 935591001122 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 935591001123 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 935591001124 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 935591001125 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 935591001126 Transglycosylase; Region: Transgly; pfam00912 935591001127 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 935591001128 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 935591001129 G1 box; other site 935591001130 GTP/Mg2+ binding site [chemical binding]; other site 935591001131 Switch I region; other site 935591001132 G2 box; other site 935591001133 G3 box; other site 935591001134 Switch II region; other site 935591001135 G4 box; other site 935591001136 G5 box; other site 935591001137 Cytochrome c553 [Energy production and conversion]; Region: COG2863 935591001138 Cytochrome c; Region: Cytochrom_C; cl11414 935591001139 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 935591001140 ResB-like family; Region: ResB; pfam05140 935591001141 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 935591001142 UGMP family protein; Validated; Region: PRK09604 935591001143 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 935591001144 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 935591001145 putative acyl-acceptor binding pocket; other site 935591001146 S-adenosylmethionine synthetase; Validated; Region: PRK05250 935591001147 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 935591001148 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 935591001149 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 935591001150 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 935591001151 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 935591001152 Predicted flavoprotein [General function prediction only]; Region: COG0431 935591001153 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 935591001154 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 935591001155 Citrate transporter; Region: CitMHS; pfam03600 935591001156 cheY-homologous receiver domain; Region: REC; smart00448 935591001157 sensor protein QseC; Provisional; Region: PRK10337 935591001158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935591001159 dimer interface [polypeptide binding]; other site 935591001160 phosphorylation site [posttranslational modification] 935591001161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935591001162 ATP binding site [chemical binding]; other site 935591001163 Mg2+ binding site [ion binding]; other site 935591001164 G-X-G motif; other site 935591001165 ribonuclease G; Provisional; Region: PRK11712 935591001166 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 935591001167 homodimer interface [polypeptide binding]; other site 935591001168 oligonucleotide binding site [chemical binding]; other site 935591001169 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 935591001170 GSH binding site [chemical binding]; other site 935591001171 catalytic residues [active] 935591001172 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 935591001173 SecA binding site; other site 935591001174 Preprotein binding site; other site 935591001175 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 935591001176 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 935591001177 generic binding surface II; other site 935591001178 ssDNA binding site; other site 935591001179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935591001180 ATP binding site [chemical binding]; other site 935591001181 putative Mg++ binding site [ion binding]; other site 935591001182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935591001183 nucleotide binding region [chemical binding]; other site 935591001184 ATP-binding site [chemical binding]; other site 935591001185 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 935591001186 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 935591001187 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 935591001188 Uncharacterized conserved protein [Function unknown]; Region: COG2850 935591001189 Cupin-like domain; Region: Cupin_8; pfam13621 935591001190 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 935591001191 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 935591001192 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 935591001193 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935591001194 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935591001195 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935591001196 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935591001197 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935591001198 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 935591001199 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935591001200 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935591001201 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935591001202 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935591001203 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935591001204 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935591001205 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935591001206 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935591001207 Helix-turn-helix domain; Region: HTH_38; pfam13936 935591001208 Homeodomain-like domain; Region: HTH_32; pfam13565 935591001209 Integrase core domain; Region: rve; pfam00665 935591001210 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 935591001211 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935591001212 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935591001213 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935591001214 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935591001215 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935591001216 RTX toxin acyltransferase family; Region: HlyC; cl01131 935591001217 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 935591001218 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 935591001219 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 935591001220 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 935591001221 HipA N-terminal domain; Region: Couple_hipA; pfam13657 935591001222 HipA-like N-terminal domain; Region: HipA_N; pfam07805 935591001223 HipA-like C-terminal domain; Region: HipA_C; pfam07804 935591001224 oxidoreductase; Region: PLN02991 935591001225 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 935591001226 Helix-turn-helix domain; Region: HTH_28; pfam13518 935591001227 Integrase core domain; Region: rve; pfam00665 935591001228 Integrase core domain; Region: rve_2; pfam13333 935591001229 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935591001230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935591001231 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935591001232 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935591001233 Zonular occludens toxin (Zot); Region: Zot; pfam05707 935591001234 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 935591001235 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 935591001236 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935591001237 Replication initiation factor; Region: Rep_trans; pfam02486 935591001238 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 935591001239 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 935591001240 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935591001241 HlyD family secretion protein; Region: HlyD_3; pfam13437 935591001242 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 935591001243 DDE superfamily endonuclease; Region: DDE_3; pfam13358 935591001244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 935591001245 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 935591001246 HD domain; Region: HD_4; pfam13328 935591001247 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 935591001248 synthetase active site [active] 935591001249 NTP binding site [chemical binding]; other site 935591001250 metal binding site [ion binding]; metal-binding site 935591001251 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 935591001252 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 935591001253 Glutaredoxin 2 [Posttranslational modification, protein turnover, chaperones]; Region: GrxB; COG2999 935591001254 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 935591001255 C-terminal domain interface [polypeptide binding]; other site 935591001256 GSH binding site (G-site) [chemical binding]; other site 935591001257 catalytic residues [active] 935591001258 putative dimer interface [polypeptide binding]; other site 935591001259 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 935591001260 N-terminal domain interface [polypeptide binding]; other site 935591001261 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 935591001262 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 935591001263 Peptidase family M50; Region: Peptidase_M50; pfam02163 935591001264 active site 935591001265 putative substrate binding region [chemical binding]; other site 935591001266 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 935591001267 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 935591001268 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 935591001269 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 935591001270 TolR protein; Region: tolR; TIGR02801 935591001271 TIGR01244 family protein; Region: TIGR01244 935591001272 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 935591001273 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 935591001274 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 935591001275 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 935591001276 protein binding site [polypeptide binding]; other site 935591001277 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 935591001278 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 935591001279 Low-spin heme binding site [chemical binding]; other site 935591001280 Putative water exit pathway; other site 935591001281 Binuclear center (active site) [active] 935591001282 Putative proton exit pathway; other site 935591001283 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 935591001284 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 935591001285 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 935591001286 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 935591001287 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 935591001288 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 935591001289 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 935591001290 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 935591001291 AbgT putative transporter family; Region: ABG_transport; pfam03806 935591001292 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 935591001293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935591001294 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 935591001295 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 935591001296 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935591001297 HlyD family secretion protein; Region: HlyD_3; pfam13437 935591001298 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 935591001299 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 935591001300 L-lactate permease; Region: Lactate_perm; cl00701 935591001301 Transcriptional regulators [Transcription]; Region: FadR; COG2186 935591001302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935591001303 DNA-binding site [nucleotide binding]; DNA binding site 935591001304 FCD domain; Region: FCD; pfam07729 935591001305 glutamate dehydrogenase; Provisional; Region: PRK09414 935591001306 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 935591001307 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 935591001308 NAD(P) binding site [chemical binding]; other site 935591001309 thymidylate synthase; Reviewed; Region: thyA; PRK01827 935591001310 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 935591001311 dimerization interface [polypeptide binding]; other site 935591001312 active site 935591001313 ApbE family; Region: ApbE; pfam02424 935591001314 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 935591001315 Na2 binding site [ion binding]; other site 935591001316 putative substrate binding site 1 [chemical binding]; other site 935591001317 Na binding site 1 [ion binding]; other site 935591001318 putative substrate binding site 2 [chemical binding]; other site 935591001319 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935591001320 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 935591001321 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 935591001322 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 935591001323 putative metal binding site; other site 935591001324 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 935591001325 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 935591001326 dimer interface [polypeptide binding]; other site 935591001327 active site 935591001328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935591001329 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 935591001330 Predicted membrane protein [Function unknown]; Region: COG4648 935591001331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4899 935591001332 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 935591001333 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 935591001334 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 935591001335 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 935591001336 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 935591001337 dihydropteroate synthase; Region: DHPS; TIGR01496 935591001338 substrate binding pocket [chemical binding]; other site 935591001339 dimer interface [polypeptide binding]; other site 935591001340 inhibitor binding site; inhibition site 935591001341 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 935591001342 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 935591001343 active site 935591001344 substrate binding site [chemical binding]; other site 935591001345 metal binding site [ion binding]; metal-binding site 935591001346 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 935591001347 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 935591001348 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 935591001349 active site 935591001350 homodimer interface [polypeptide binding]; other site 935591001351 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 935591001352 active site 935591001353 peptide chain release factor 1; Validated; Region: prfA; PRK00591 935591001354 This domain is found in peptide chain release factors; Region: PCRF; smart00937 935591001355 RF-1 domain; Region: RF-1; pfam00472 935591001356 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 935591001357 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 935591001358 putative ligand binding site [chemical binding]; other site 935591001359 putative NAD binding site [chemical binding]; other site 935591001360 catalytic site [active] 935591001361 seryl-tRNA synthetase; Provisional; Region: PRK05431 935591001362 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 935591001363 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 935591001364 dimer interface [polypeptide binding]; other site 935591001365 active site 935591001366 motif 1; other site 935591001367 motif 2; other site 935591001368 motif 3; other site 935591001369 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 935591001370 putative active site [active] 935591001371 Ap4A binding site [chemical binding]; other site 935591001372 nudix motif; other site 935591001373 putative metal binding site [ion binding]; other site 935591001374 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 935591001375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935591001376 ATP binding site [chemical binding]; other site 935591001377 Mg2+ binding site [ion binding]; other site 935591001378 G-X-G motif; other site 935591001379 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 935591001380 anchoring element; other site 935591001381 dimer interface [polypeptide binding]; other site 935591001382 ATP binding site [chemical binding]; other site 935591001383 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 935591001384 active site 935591001385 metal binding site [ion binding]; metal-binding site 935591001386 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 935591001387 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 935591001388 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 935591001389 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 935591001390 Tetramer interface [polypeptide binding]; other site 935591001391 active site 935591001392 FMN-binding site [chemical binding]; other site 935591001393 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 935591001394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591001395 S-adenosylmethionine binding site [chemical binding]; other site 935591001396 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 935591001397 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935591001398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591001399 homodimer interface [polypeptide binding]; other site 935591001400 catalytic residue [active] 935591001401 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 935591001402 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 935591001403 glycine dehydrogenase; Provisional; Region: PRK05367 935591001404 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 935591001405 tetramer interface [polypeptide binding]; other site 935591001406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591001407 catalytic residue [active] 935591001408 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 935591001409 tetramer interface [polypeptide binding]; other site 935591001410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591001411 catalytic residue [active] 935591001412 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 935591001413 active site 935591001414 catalytic triad [active] 935591001415 oxyanion hole [active] 935591001416 switch loop; other site 935591001417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 935591001418 Protein of unknown function (DUF330); Region: DUF330; pfam03886 935591001419 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 935591001420 mce related protein; Region: MCE; pfam02470 935591001421 mce related protein; Region: MCE; pfam02470 935591001422 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 935591001423 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 935591001424 Paraquat-inducible protein A; Region: PqiA; pfam04403 935591001425 Paraquat-inducible protein A; Region: PqiA; pfam04403 935591001426 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 935591001427 heme binding pocket [chemical binding]; other site 935591001428 heme ligand [chemical binding]; other site 935591001429 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 935591001430 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935591001431 N-terminal plug; other site 935591001432 ligand-binding site [chemical binding]; other site 935591001433 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 935591001434 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 935591001435 putative active site [active] 935591001436 putative protease; Provisional; Region: PRK15452 935591001437 Peptidase family U32; Region: Peptidase_U32; pfam01136 935591001438 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 935591001439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935591001440 active site 935591001441 motif I; other site 935591001442 motif II; other site 935591001443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935591001444 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935591001445 active site 935591001446 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 935591001447 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 935591001448 catalytic site [active] 935591001449 G-X2-G-X-G-K; other site 935591001450 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 935591001451 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 935591001452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935591001453 Zn2+ binding site [ion binding]; other site 935591001454 Mg2+ binding site [ion binding]; other site 935591001455 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 935591001456 synthetase active site [active] 935591001457 NTP binding site [chemical binding]; other site 935591001458 metal binding site [ion binding]; metal-binding site 935591001459 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 935591001460 ACT domain; Region: ACT_4; pfam13291 935591001461 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 935591001462 Flavoprotein; Region: Flavoprotein; pfam02441 935591001463 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 935591001464 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 935591001465 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 935591001466 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 935591001467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591001468 S-adenosylmethionine binding site [chemical binding]; other site 935591001469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 935591001470 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 935591001471 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 935591001472 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 935591001473 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 935591001474 active site 935591001475 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935591001476 substrate binding site [chemical binding]; other site 935591001477 catalytic residues [active] 935591001478 dimer interface [polypeptide binding]; other site 935591001479 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 935591001480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935591001481 putative DNA binding site [nucleotide binding]; other site 935591001482 putative Zn2+ binding site [ion binding]; other site 935591001483 AsnC family; Region: AsnC_trans_reg; pfam01037 935591001484 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 935591001485 hypothetical protein; Validated; Region: PRK00110 935591001486 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935591001487 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 935591001488 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 935591001489 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 935591001490 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 935591001491 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 935591001492 G1 box; other site 935591001493 GTP/Mg2+ binding site [chemical binding]; other site 935591001494 G2 box; other site 935591001495 Switch I region; other site 935591001496 G3 box; other site 935591001497 Switch II region; other site 935591001498 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 935591001499 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 935591001500 translation initiation factor IF-2; Region: IF-2; TIGR00487 935591001501 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 935591001502 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 935591001503 G1 box; other site 935591001504 putative GEF interaction site [polypeptide binding]; other site 935591001505 GTP/Mg2+ binding site [chemical binding]; other site 935591001506 Switch I region; other site 935591001507 G2 box; other site 935591001508 G3 box; other site 935591001509 Switch II region; other site 935591001510 G4 box; other site 935591001511 G5 box; other site 935591001512 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 935591001513 Translation-initiation factor 2; Region: IF-2; pfam11987 935591001514 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 935591001515 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 935591001516 NusA N-terminal domain; Region: NusA_N; pfam08529 935591001517 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 935591001518 RNA binding site [nucleotide binding]; other site 935591001519 homodimer interface [polypeptide binding]; other site 935591001520 NusA-like KH domain; Region: KH_5; pfam13184 935591001521 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 935591001522 G-X-X-G motif; other site 935591001523 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 935591001524 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 935591001525 ribosome maturation protein RimP; Reviewed; Region: PRK00092 935591001526 Sm and related proteins; Region: Sm_like; cl00259 935591001527 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 935591001528 putative oligomer interface [polypeptide binding]; other site 935591001529 putative RNA binding site [nucleotide binding]; other site 935591001530 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 935591001531 homodimer interface [polypeptide binding]; other site 935591001532 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 935591001533 substrate-cofactor binding pocket; other site 935591001534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591001535 catalytic residue [active] 935591001536 putative metal dependent hydrolase; Provisional; Region: PRK11598 935591001537 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 935591001538 Sulfatase; Region: Sulfatase; pfam00884 935591001539 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 935591001540 putative FMN binding site [chemical binding]; other site 935591001541 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935591001542 Uncharacterized conserved protein [Function unknown]; Region: COG1262 935591001543 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 935591001544 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 935591001545 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 935591001546 Multicopper oxidase; Region: Cu-oxidase; pfam00394 935591001547 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 935591001548 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 935591001549 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 935591001550 catalytic residues [active] 935591001551 dimer interface [polypeptide binding]; other site 935591001552 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 935591001553 dimer interface [polypeptide binding]; other site 935591001554 catalytic triad [active] 935591001555 HIT domain; Region: HIT; pfam01230 935591001556 HIT family signature motif; other site 935591001557 catalytic residue [active] 935591001558 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 935591001559 RNA/DNA hybrid binding site [nucleotide binding]; other site 935591001560 active site 935591001561 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 935591001562 tellurite resistance protein TehB; Provisional; Region: PRK12335 935591001563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 935591001564 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 935591001565 dimer interface [polypeptide binding]; other site 935591001566 substrate binding site [chemical binding]; other site 935591001567 ATP binding site [chemical binding]; other site 935591001568 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 935591001569 TrkA-N domain; Region: TrkA_N; pfam02254 935591001570 TrkA-C domain; Region: TrkA_C; pfam02080 935591001571 TrkA-N domain; Region: TrkA_N; pfam02254 935591001572 TrkA-C domain; Region: TrkA_C; pfam02080 935591001573 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 935591001574 Fumarase C-terminus; Region: Fumerase_C; pfam05683 935591001575 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 935591001576 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 935591001577 substrate binding pocket [chemical binding]; other site 935591001578 membrane-bound complex binding site; other site 935591001579 hinge residues; other site 935591001580 O-succinylhomoserine sulfhydrylase; Region: O_suc_HS_sulf; TIGR01325 935591001581 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 935591001582 homodimer interface [polypeptide binding]; other site 935591001583 substrate-cofactor binding pocket; other site 935591001584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591001585 catalytic residue [active] 935591001586 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 935591001587 Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445 935591001588 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 935591001589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935591001590 active site 935591001591 phosphorylation site [posttranslational modification] 935591001592 intermolecular recognition site; other site 935591001593 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 935591001594 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 935591001595 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 935591001596 CAP-like domain; other site 935591001597 active site 935591001598 primary dimer interface [polypeptide binding]; other site 935591001599 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935591001600 catalytic core [active] 935591001601 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935591001602 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 935591001603 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 935591001604 gating phenylalanine in ion channel; other site 935591001605 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 935591001606 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935591001607 cofactor binding site; other site 935591001608 DNA binding site [nucleotide binding] 935591001609 substrate interaction site [chemical binding]; other site 935591001610 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 935591001611 motif 1; other site 935591001612 active site 935591001613 motif 2; other site 935591001614 motif 3; other site 935591001615 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 935591001616 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 935591001617 DHHA1 domain; Region: DHHA1; pfam02272 935591001618 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 935591001619 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935591001620 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 935591001621 EamA-like transporter family; Region: EamA; pfam00892 935591001622 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 935591001623 Cupin; Region: Cupin_6; pfam12852 935591001624 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 935591001625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 935591001626 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 935591001627 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 935591001628 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 935591001629 putative inner membrane peptidase; Provisional; Region: PRK11778 935591001630 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 935591001631 tandem repeat interface [polypeptide binding]; other site 935591001632 oligomer interface [polypeptide binding]; other site 935591001633 active site residues [active] 935591001634 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 935591001635 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 935591001636 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 935591001637 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 935591001638 putative active site pocket [active] 935591001639 4-fold oligomerization interface [polypeptide binding]; other site 935591001640 metal binding residues [ion binding]; metal-binding site 935591001641 3-fold/trimer interface [polypeptide binding]; other site 935591001642 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 935591001643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935591001644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591001645 homodimer interface [polypeptide binding]; other site 935591001646 catalytic residue [active] 935591001647 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 935591001648 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 935591001649 NAD binding site [chemical binding]; other site 935591001650 dimerization interface [polypeptide binding]; other site 935591001651 product binding site; other site 935591001652 substrate binding site [chemical binding]; other site 935591001653 zinc binding site [ion binding]; other site 935591001654 catalytic residues [active] 935591001655 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 935591001656 GIY-YIG motif/motif A; other site 935591001657 putative active site [active] 935591001658 putative metal binding site [ion binding]; other site 935591001659 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 935591001660 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 935591001661 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 935591001662 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935591001663 Cu(I) binding site [ion binding]; other site 935591001664 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 935591001665 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 935591001666 PYR/PP interface [polypeptide binding]; other site 935591001667 dimer interface [polypeptide binding]; other site 935591001668 TPP binding site [chemical binding]; other site 935591001669 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 935591001670 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 935591001671 TPP-binding site [chemical binding]; other site 935591001672 dimer interface [polypeptide binding]; other site 935591001673 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 935591001674 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 935591001675 putative valine binding site [chemical binding]; other site 935591001676 dimer interface [polypeptide binding]; other site 935591001677 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 935591001678 Uncharacterized conserved protein [Function unknown]; Region: COG1359 935591001679 ketol-acid reductoisomerase; Provisional; Region: PRK05479 935591001680 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 935591001681 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 935591001682 ornithine carbamoyltransferase; Validated; Region: PRK02102 935591001683 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 935591001684 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 935591001685 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 935591001686 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 935591001687 substrate binding site [chemical binding]; other site 935591001688 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 935591001689 substrate binding site [chemical binding]; other site 935591001690 ligand binding site [chemical binding]; other site 935591001691 Predicted permeases [General function prediction only]; Region: COG0795 935591001692 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 935591001693 Predicted permeases [General function prediction only]; Region: COG0795 935591001694 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 935591001695 multifunctional aminopeptidase A; Provisional; Region: PRK00913 935591001696 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 935591001697 interface (dimer of trimers) [polypeptide binding]; other site 935591001698 Substrate-binding/catalytic site; other site 935591001699 Zn-binding sites [ion binding]; other site 935591001700 DNA polymerase III, chi subunit [DNA replication, recombination, and repair]; Region: HolC; COG2927 935591001701 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 935591001702 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 935591001703 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935591001704 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 935591001705 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 935591001706 active site 935591001707 substrate binding site [chemical binding]; other site 935591001708 cosubstrate binding site; other site 935591001709 catalytic site [active] 935591001710 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 935591001711 OsmC-like protein; Region: OsmC; cl00767 935591001712 Transcriptional regulators [Transcription]; Region: GntR; COG1802 935591001713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935591001714 DNA-binding site [nucleotide binding]; DNA binding site 935591001715 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 935591001716 Predicted membrane protein [Function unknown]; Region: COG2431 935591001717 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 935591001718 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935591001719 putative DNA binding site [nucleotide binding]; other site 935591001720 putative Zn2+ binding site [ion binding]; other site 935591001721 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 935591001722 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 935591001723 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935591001724 active site 935591001725 HIGH motif; other site 935591001726 nucleotide binding site [chemical binding]; other site 935591001727 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 935591001728 KMSKS motif; other site 935591001729 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 935591001730 glutathione synthetase; Provisional; Region: PRK05246 935591001731 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 935591001732 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 935591001733 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 935591001734 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 935591001735 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 935591001736 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 935591001737 Ligand Binding Site [chemical binding]; other site 935591001738 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 935591001739 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 935591001740 acyl-activating enzyme (AAE) consensus motif; other site 935591001741 putative AMP binding site [chemical binding]; other site 935591001742 putative active site [active] 935591001743 putative CoA binding site [chemical binding]; other site 935591001744 CTP synthetase; Validated; Region: pyrG; PRK05380 935591001745 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 935591001746 Catalytic site [active] 935591001747 active site 935591001748 UTP binding site [chemical binding]; other site 935591001749 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 935591001750 active site 935591001751 putative oxyanion hole; other site 935591001752 catalytic triad [active] 935591001753 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935591001754 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935591001755 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 935591001756 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935591001757 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935591001758 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935591001759 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 935591001760 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 935591001761 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 935591001762 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 935591001763 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935591001764 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 935591001765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935591001766 DNA binding residues [nucleotide binding] 935591001767 DNA primase; Validated; Region: dnaG; PRK05667 935591001768 CHC2 zinc finger; Region: zf-CHC2; pfam01807 935591001769 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 935591001770 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 935591001771 active site 935591001772 metal binding site [ion binding]; metal-binding site 935591001773 interdomain interaction site; other site 935591001774 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 935591001775 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 935591001776 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 935591001777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 935591001778 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 935591001779 SEC-C motif; Region: SEC-C; pfam02810 935591001780 Protein of unknown function (DUF721); Region: DUF721; pfam05258 935591001781 Azurin [Energy production and conversion]; Region: COG3241 935591001782 Hemerythrin-like domain; Region: Hr-like; cd12108 935591001783 Fe binding site [ion binding]; other site 935591001784 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 935591001785 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 935591001786 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 935591001787 metal binding site [ion binding]; metal-binding site 935591001788 dimer interface [polypeptide binding]; other site 935591001789 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 935591001790 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 935591001791 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 935591001792 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 935591001793 DNA binding site [nucleotide binding] 935591001794 active site 935591001795 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 935591001796 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 935591001797 putative active site [active] 935591001798 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 935591001799 SmpB-tmRNA interface; other site 935591001800 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 935591001801 FAD binding domain; Region: FAD_binding_4; pfam01565 935591001802 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 935591001803 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935591001804 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 935591001805 active site lid residues [active] 935591001806 substrate binding pocket [chemical binding]; other site 935591001807 catalytic residues [active] 935591001808 substrate-Mg2+ binding site; other site 935591001809 aspartate-rich region 1; other site 935591001810 aspartate-rich region 2; other site 935591001811 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 935591001812 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 935591001813 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 935591001814 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 935591001815 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 935591001816 DsbD alpha interface [polypeptide binding]; other site 935591001817 catalytic residues [active] 935591001818 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 935591001819 propionate/acetate kinase; Provisional; Region: PRK12379 935591001820 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 935591001821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935591001822 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 935591001823 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 935591001824 active site 935591001825 catalytic site [active] 935591001826 substrate binding site [chemical binding]; other site 935591001827 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 935591001828 substrate binding site; other site 935591001829 dimer interface; other site 935591001830 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 935591001831 homotrimer interaction site [polypeptide binding]; other site 935591001832 zinc binding site [ion binding]; other site 935591001833 CDP-binding sites; other site 935591001834 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 935591001835 tetramer (dimer of dimers) interface [polypeptide binding]; other site 935591001836 active site 935591001837 dimer interface [polypeptide binding]; other site 935591001838 Staphylococcal nuclease homologues; Region: SNc; smart00318 935591001839 Catalytic site; other site 935591001840 Staphylococcal nuclease homologue; Region: SNase; pfam00565 935591001841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935591001842 dimer interface [polypeptide binding]; other site 935591001843 conserved gate region; other site 935591001844 putative PBP binding loops; other site 935591001845 ABC-ATPase subunit interface; other site 935591001846 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 935591001847 Sulfatase; Region: Sulfatase; cl17466 935591001848 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 935591001849 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 935591001850 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 935591001851 active site 935591001852 HIGH motif; other site 935591001853 KMSK motif region; other site 935591001854 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 935591001855 tRNA binding surface [nucleotide binding]; other site 935591001856 anticodon binding site; other site 935591001857 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 935591001858 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 935591001859 active site 935591001860 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 935591001861 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 935591001862 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 935591001863 putative ATP binding site [chemical binding]; other site 935591001864 putative substrate interface [chemical binding]; other site 935591001865 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 935591001866 Ligand Binding Site [chemical binding]; other site 935591001867 ribonuclease PH; Reviewed; Region: rph; PRK00173 935591001868 Ribonuclease PH; Region: RNase_PH_bact; cd11362 935591001869 hexamer interface [polypeptide binding]; other site 935591001870 active site 935591001871 aspartate kinase; Reviewed; Region: PRK06635 935591001872 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 935591001873 putative nucleotide binding site [chemical binding]; other site 935591001874 putative catalytic residues [active] 935591001875 putative Mg ion binding site [ion binding]; other site 935591001876 putative aspartate binding site [chemical binding]; other site 935591001877 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 935591001878 putative allosteric regulatory site; other site 935591001879 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 935591001880 Replication initiation factor; Region: Rep_trans; pfam02486 935591001881 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935591001882 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 935591001883 Zonular occludens toxin (Zot); Region: Zot; cl17485 935591001884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935591001885 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935591001886 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935591001887 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 935591001888 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 935591001889 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935591001890 Uncharacterized small protein [Function unknown]; Region: COG2879 935591001891 carbon starvation protein A; Provisional; Region: PRK15015 935591001892 Carbon starvation protein CstA; Region: CstA; pfam02554 935591001893 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 935591001894 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 935591001895 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 935591001896 succinic semialdehyde dehydrogenase; Region: PLN02278 935591001897 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 935591001898 tetramerization interface [polypeptide binding]; other site 935591001899 NAD(P) binding site [chemical binding]; other site 935591001900 catalytic residues [active] 935591001901 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 935591001902 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 935591001903 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 935591001904 Transporter associated domain; Region: CorC_HlyC; smart01091 935591001905 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 935591001906 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935591001907 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935591001908 Peptidase family M23; Region: Peptidase_M23; pfam01551 935591001909 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 935591001910 recombination regulator RecX; Reviewed; Region: recX; PRK00117 935591001911 phosphoglycolate phosphatase; Provisional; Region: PRK13222 935591001912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935591001913 motif II; other site 935591001914 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 935591001915 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 935591001916 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 935591001917 NAD(P) binding site [chemical binding]; other site 935591001918 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 935591001919 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 935591001920 active site 1 [active] 935591001921 dimer interface [polypeptide binding]; other site 935591001922 hexamer interface [polypeptide binding]; other site 935591001923 active site 2 [active] 935591001924 aminotransferase AlaT; Validated; Region: PRK09265 935591001925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935591001926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591001927 homodimer interface [polypeptide binding]; other site 935591001928 catalytic residue [active] 935591001929 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 935591001930 Clp amino terminal domain; Region: Clp_N; pfam02861 935591001931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591001932 Walker A motif; other site 935591001933 ATP binding site [chemical binding]; other site 935591001934 Walker B motif; other site 935591001935 arginine finger; other site 935591001936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591001937 Walker A motif; other site 935591001938 ATP binding site [chemical binding]; other site 935591001939 Walker B motif; other site 935591001940 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 935591001941 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 935591001942 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 935591001943 active site 935591001944 HIGH motif; other site 935591001945 dimer interface [polypeptide binding]; other site 935591001946 KMSKS motif; other site 935591001947 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 935591001948 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 935591001949 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935591001950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 935591001951 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 935591001952 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935591001953 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935591001954 catalytic residue [active] 935591001955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935591001956 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935591001957 putative substrate translocation pore; other site 935591001958 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 935591001959 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 935591001960 dimer interface [polypeptide binding]; other site 935591001961 ssDNA binding site [nucleotide binding]; other site 935591001962 tetramer (dimer of dimers) interface [polypeptide binding]; other site 935591001963 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 935591001964 EamA-like transporter family; Region: EamA; pfam00892 935591001965 fumarate hydratase; Reviewed; Region: fumC; PRK00485 935591001966 Class II fumarases; Region: Fumarase_classII; cd01362 935591001967 active site 935591001968 tetramer interface [polypeptide binding]; other site 935591001969 transketolase; Reviewed; Region: PRK12753 935591001970 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 935591001971 TPP-binding site [chemical binding]; other site 935591001972 dimer interface [polypeptide binding]; other site 935591001973 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 935591001974 PYR/PP interface [polypeptide binding]; other site 935591001975 dimer interface [polypeptide binding]; other site 935591001976 TPP binding site [chemical binding]; other site 935591001977 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 935591001978 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 935591001979 4Fe-4S binding domain; Region: Fer4_5; pfam12801 935591001980 4Fe-4S binding domain; Region: Fer4_3; pfam12798 935591001981 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 935591001982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 935591001983 FixH; Region: FixH; pfam05751 935591001984 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 935591001985 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 935591001986 FMN binding site [chemical binding]; other site 935591001987 substrate binding site [chemical binding]; other site 935591001988 putative catalytic residue [active] 935591001989 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 935591001990 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 935591001991 active site 935591001992 catalytic site [active] 935591001993 substrate binding site [chemical binding]; other site 935591001994 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 935591001995 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 935591001996 FAD binding pocket [chemical binding]; other site 935591001997 FAD binding motif [chemical binding]; other site 935591001998 phosphate binding motif [ion binding]; other site 935591001999 beta-alpha-beta structure motif; other site 935591002000 NAD binding pocket [chemical binding]; other site 935591002001 Transposase domain (DUF772); Region: DUF772; pfam05598 935591002002 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591002003 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935591002004 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935591002005 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 935591002006 active site 935591002007 DNA polymerase IV; Validated; Region: PRK02406 935591002008 DNA binding site [nucleotide binding] 935591002009 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 935591002010 Family description; Region: UvrD_C_2; pfam13538 935591002011 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 935591002012 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 935591002013 active site 935591002014 catalytic residue [active] 935591002015 dimer interface [polypeptide binding]; other site 935591002016 recombinase A; Provisional; Region: recA; PRK09354 935591002017 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 935591002018 hexamer interface [polypeptide binding]; other site 935591002019 Walker A motif; other site 935591002020 ATP binding site [chemical binding]; other site 935591002021 Walker B motif; other site 935591002022 hypothetical protein; Validated; Region: PRK00153 935591002023 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08691 935591002024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591002025 Walker A motif; other site 935591002026 ATP binding site [chemical binding]; other site 935591002027 Walker B motif; other site 935591002028 arginine finger; other site 935591002029 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 935591002030 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 935591002031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935591002032 ATP binding site [chemical binding]; other site 935591002033 Mg2+ binding site [ion binding]; other site 935591002034 G-X-G motif; other site 935591002035 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 935591002036 ATP binding site [chemical binding]; other site 935591002037 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 935591002038 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 935591002039 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 935591002040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591002041 S-adenosylmethionine binding site [chemical binding]; other site 935591002042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 935591002043 Tetratricopeptide repeat; Region: TPR_6; pfam13174 935591002044 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 935591002045 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 935591002046 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 935591002047 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 935591002048 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 935591002049 Uncharacterized conserved protein [Function unknown]; Region: COG1556 935591002050 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 935591002051 Cysteine-rich domain; Region: CCG; pfam02754 935591002052 Cysteine-rich domain; Region: CCG; pfam02754 935591002053 putative transporter; Provisional; Region: PRK10504 935591002054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935591002055 putative substrate translocation pore; other site 935591002056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935591002057 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 935591002058 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 935591002059 putative active site [active] 935591002060 catalytic site [active] 935591002061 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 935591002062 putative active site [active] 935591002063 catalytic site [active] 935591002064 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 935591002065 NlpC/P60 family; Region: NLPC_P60; pfam00877 935591002066 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 935591002067 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 935591002068 hinge; other site 935591002069 active site 935591002070 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 935591002071 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 935591002072 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 935591002073 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 935591002074 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 935591002075 eyelet of channel; other site 935591002076 trimer interface [polypeptide binding]; other site 935591002077 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 935591002078 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 935591002079 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 935591002080 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 935591002081 active site 935591002082 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 935591002083 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 935591002084 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 935591002085 dimer interface [polypeptide binding]; other site 935591002086 putative anticodon binding site; other site 935591002087 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 935591002088 motif 1; other site 935591002089 active site 935591002090 motif 2; other site 935591002091 motif 3; other site 935591002092 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935591002093 Catalytic site [active] 935591002094 Fic family protein [Function unknown]; Region: COG3177 935591002095 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 935591002096 Fic/DOC family; Region: Fic; pfam02661 935591002097 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 935591002098 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 935591002099 ATP binding site [chemical binding]; other site 935591002100 Mg++ binding site [ion binding]; other site 935591002101 motif III; other site 935591002102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935591002103 nucleotide binding region [chemical binding]; other site 935591002104 ATP-binding site [chemical binding]; other site 935591002105 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 935591002106 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 935591002107 FMN binding site [chemical binding]; other site 935591002108 active site 935591002109 catalytic residues [active] 935591002110 substrate binding site [chemical binding]; other site 935591002111 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 935591002112 DNA-binding protein Fis; Provisional; Region: PRK01905 935591002113 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 935591002114 active site 935591002115 putative DNA-binding cleft [nucleotide binding]; other site 935591002116 dimer interface [polypeptide binding]; other site 935591002117 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 935591002118 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 935591002119 putative acyl-acceptor binding pocket; other site 935591002120 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 935591002121 active site 935591002122 catalytic site [active] 935591002123 substrate binding site [chemical binding]; other site 935591002124 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 935591002125 aminopeptidase N; Provisional; Region: pepN; PRK14015 935591002126 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 935591002127 active site 935591002128 Zn binding site [ion binding]; other site 935591002129 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 935591002130 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 935591002131 RTX iron-regulated protein FrpC; Region: FrpC; pfam06901 935591002132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935591002133 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 935591002134 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 935591002135 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935591002136 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 935591002137 Walker A/P-loop; other site 935591002138 ATP binding site [chemical binding]; other site 935591002139 Q-loop/lid; other site 935591002140 ABC transporter signature motif; other site 935591002141 Walker B; other site 935591002142 D-loop; other site 935591002143 H-loop/switch region; other site 935591002144 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 935591002145 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935591002146 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935591002147 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 935591002148 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 935591002149 E-class dimer interface [polypeptide binding]; other site 935591002150 P-class dimer interface [polypeptide binding]; other site 935591002151 active site 935591002152 Cu2+ binding site [ion binding]; other site 935591002153 Zn2+ binding site [ion binding]; other site 935591002154 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 935591002155 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 935591002156 minor groove reading motif; other site 935591002157 helix-hairpin-helix signature motif; other site 935591002158 substrate binding pocket [chemical binding]; other site 935591002159 active site 935591002160 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 935591002161 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 935591002162 DNA binding and oxoG recognition site [nucleotide binding] 935591002163 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 935591002164 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 935591002165 active site 935591002166 intersubunit interface [polypeptide binding]; other site 935591002167 catalytic residue [active] 935591002168 phosphogluconate dehydratase; Validated; Region: PRK09054 935591002169 6-phosphogluconate dehydratase; Region: edd; TIGR01196 935591002170 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 935591002171 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 935591002172 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 935591002173 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 935591002174 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 935591002175 putative active site [active] 935591002176 glucokinase; Provisional; Region: glk; PRK00292 935591002177 glucokinase, proteobacterial type; Region: glk; TIGR00749 935591002178 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 935591002179 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 935591002180 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 935591002181 putative active site [active] 935591002182 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 935591002183 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 935591002184 active site 935591002185 dimer interface [polypeptide binding]; other site 935591002186 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 935591002187 dimer interface [polypeptide binding]; other site 935591002188 active site 935591002189 DNA gyrase subunit A; Validated; Region: PRK05560 935591002190 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 935591002191 CAP-like domain; other site 935591002192 active site 935591002193 primary dimer interface [polypeptide binding]; other site 935591002194 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935591002195 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935591002196 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935591002197 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935591002198 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935591002199 co-chaperone HscB; Provisional; Region: hscB; PRK03578 935591002200 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935591002201 HSP70 interaction site [polypeptide binding]; other site 935591002202 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 935591002203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 935591002204 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 935591002205 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 935591002206 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 935591002207 trimerization site [polypeptide binding]; other site 935591002208 active site 935591002209 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 935591002210 cysteine desulfurase; Provisional; Region: PRK14012 935591002211 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 935591002212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 935591002213 catalytic residue [active] 935591002214 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 935591002215 Rrf2 family protein; Region: rrf2_super; TIGR00738 935591002216 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 935591002217 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935591002218 phosphate binding site [ion binding]; other site 935591002219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 935591002220 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 935591002221 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 935591002222 DNA methylase; Region: N6_N4_Mtase; pfam01555 935591002223 DNA methylase; Region: N6_N4_Mtase; pfam01555 935591002224 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 935591002225 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 935591002226 RNA binding site [nucleotide binding]; other site 935591002227 active site 935591002228 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 935591002229 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 935591002230 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 935591002231 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 935591002232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591002233 Walker A motif; other site 935591002234 ATP binding site [chemical binding]; other site 935591002235 Walker B motif; other site 935591002236 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 935591002237 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 935591002238 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935591002239 inhibitor-cofactor binding pocket; inhibition site 935591002240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591002241 catalytic residue [active] 935591002242 helicase 45; Provisional; Region: PTZ00424 935591002243 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 935591002244 ATP binding site [chemical binding]; other site 935591002245 Mg++ binding site [ion binding]; other site 935591002246 motif III; other site 935591002247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935591002248 nucleotide binding region [chemical binding]; other site 935591002249 ATP-binding site [chemical binding]; other site 935591002250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591002251 S-adenosylmethionine binding site [chemical binding]; other site 935591002252 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 935591002253 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935591002254 catalytic residues [active] 935591002255 Hemerythrin-like domain; Region: Hr-like; cd12108 935591002256 Fe binding site [ion binding]; other site 935591002257 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 935591002258 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 935591002259 homodimer interface [polypeptide binding]; other site 935591002260 NAD binding pocket [chemical binding]; other site 935591002261 ATP binding pocket [chemical binding]; other site 935591002262 Mg binding site [ion binding]; other site 935591002263 active-site loop [active] 935591002264 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 935591002265 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 935591002266 generic binding surface II; other site 935591002267 generic binding surface I; other site 935591002268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935591002269 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935591002270 putative substrate translocation pore; other site 935591002271 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 935591002272 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935591002273 RNA binding surface [nucleotide binding]; other site 935591002274 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 935591002275 probable active site [active] 935591002276 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 935591002277 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 935591002278 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 935591002279 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 935591002280 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935591002281 catalytic loop [active] 935591002282 iron binding site [ion binding]; other site 935591002283 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 935591002284 FAD binding pocket [chemical binding]; other site 935591002285 FAD binding motif [chemical binding]; other site 935591002286 phosphate binding motif [ion binding]; other site 935591002287 beta-alpha-beta structure motif; other site 935591002288 NAD binding pocket [chemical binding]; other site 935591002289 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 935591002290 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 935591002291 GatB domain; Region: GatB_Yqey; smart00845 935591002292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 935591002293 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 935591002294 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 935591002295 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 935591002296 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 935591002297 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 935591002298 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 935591002299 NAD(P) binding site [chemical binding]; other site 935591002300 catalytic residues [active] 935591002301 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 935591002302 16S rRNA methyltransferase B; Provisional; Region: PRK10901 935591002303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591002304 S-adenosylmethionine binding site [chemical binding]; other site 935591002305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3782 935591002306 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 935591002307 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 935591002308 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935591002309 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 935591002310 active site 935591002311 dimerization interface [polypeptide binding]; other site 935591002312 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 935591002313 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935591002314 N-terminal plug; other site 935591002315 ligand-binding site [chemical binding]; other site 935591002316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 935591002317 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 935591002318 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935591002319 E3 interaction surface; other site 935591002320 lipoyl attachment site [posttranslational modification]; other site 935591002321 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 935591002322 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 935591002323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935591002324 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935591002325 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 935591002326 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935591002327 E3 interaction surface; other site 935591002328 lipoyl attachment site [posttranslational modification]; other site 935591002329 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935591002330 E3 interaction surface; other site 935591002331 lipoyl attachment site [posttranslational modification]; other site 935591002332 e3 binding domain; Region: E3_binding; pfam02817 935591002333 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 935591002334 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 935591002335 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 935591002336 dimer interface [polypeptide binding]; other site 935591002337 TPP-binding site [chemical binding]; other site 935591002338 prolyl-tRNA synthetase; Provisional; Region: PRK09194 935591002339 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 935591002340 dimer interface [polypeptide binding]; other site 935591002341 motif 1; other site 935591002342 active site 935591002343 motif 2; other site 935591002344 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 935591002345 putative deacylase active site [active] 935591002346 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935591002347 active site 935591002348 motif 3; other site 935591002349 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 935591002350 anticodon binding site; other site 935591002351 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 935591002352 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 935591002353 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 935591002354 Putative transcriptional regulator [Transcription]; Region: COG1678 935591002355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 935591002356 CreA protein; Region: CreA; pfam05981 935591002357 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 935591002358 Peptidase family M23; Region: Peptidase_M23; pfam01551 935591002359 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 935591002360 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 935591002361 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 935591002362 protein binding site [polypeptide binding]; other site 935591002363 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 935591002364 Catalytic dyad [active] 935591002365 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 935591002366 excinuclease ABC subunit B; Provisional; Region: PRK05298 935591002367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935591002368 ATP-binding site [chemical binding]; other site 935591002369 ATP binding site [chemical binding]; other site 935591002370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935591002371 nucleotide binding region [chemical binding]; other site 935591002372 ATP-binding site [chemical binding]; other site 935591002373 Ultra-violet resistance protein B; Region: UvrB; pfam12344 935591002374 UvrB/uvrC motif; Region: UVR; pfam02151 935591002375 beta-amyloid precursor protein C-terminus; Region: APP_amyloid; pfam10515 935591002376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 935591002377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591002378 S-adenosylmethionine binding site [chemical binding]; other site 935591002379 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935591002380 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935591002381 Sel1-like repeats; Region: SEL1; smart00671 935591002382 Sel1-like repeats; Region: SEL1; smart00671 935591002383 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 935591002384 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 935591002385 GIY-YIG motif/motif A; other site 935591002386 active site 935591002387 catalytic site [active] 935591002388 putative DNA binding site [nucleotide binding]; other site 935591002389 metal binding site [ion binding]; metal-binding site 935591002390 UvrB/uvrC motif; Region: UVR; pfam02151 935591002391 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 935591002392 Helix-hairpin-helix motif; Region: HHH; pfam00633 935591002393 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 935591002394 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935591002395 metal-binding site [ion binding] 935591002396 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 935591002397 Soluble P-type ATPase [General function prediction only]; Region: COG4087 935591002398 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 935591002399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935591002400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935591002401 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 935591002402 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 935591002403 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 935591002404 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 935591002405 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 935591002406 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 935591002407 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 935591002408 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 935591002409 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 935591002410 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 935591002411 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 935591002412 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 935591002413 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 935591002414 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 935591002415 trigger factor; Provisional; Region: tig; PRK01490 935591002416 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935591002417 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 935591002418 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 935591002419 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 935591002420 oligomer interface [polypeptide binding]; other site 935591002421 active site residues [active] 935591002422 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 935591002423 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 935591002424 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 935591002425 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 935591002426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935591002427 binding surface 935591002428 TPR motif; other site 935591002429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935591002430 TPR motif; other site 935591002431 binding surface 935591002432 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 935591002433 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935591002434 FeS/SAM binding site; other site 935591002435 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 935591002436 active site 935591002437 multimer interface [polypeptide binding]; other site 935591002438 Predicted ATPase [General function prediction only]; Region: COG1485 935591002439 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 935591002440 S-formylglutathione hydrolase; Region: PLN02442 935591002441 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 935591002442 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 935591002443 substrate binding site [chemical binding]; other site 935591002444 catalytic Zn binding site [ion binding]; other site 935591002445 NAD binding site [chemical binding]; other site 935591002446 structural Zn binding site [ion binding]; other site 935591002447 dimer interface [polypeptide binding]; other site 935591002448 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 935591002449 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 935591002450 DNA binding residues [nucleotide binding] 935591002451 putative dimer interface [polypeptide binding]; other site 935591002452 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 935591002453 IHF dimer interface [polypeptide binding]; other site 935591002454 IHF - DNA interface [nucleotide binding]; other site 935591002455 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 935591002456 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 935591002457 RNA binding site [nucleotide binding]; other site 935591002458 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 935591002459 RNA binding site [nucleotide binding]; other site 935591002460 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 935591002461 RNA binding site [nucleotide binding]; other site 935591002462 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 935591002463 RNA binding site [nucleotide binding]; other site 935591002464 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 935591002465 RNA binding site [nucleotide binding]; other site 935591002466 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 935591002467 RNA binding site [nucleotide binding]; other site 935591002468 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 935591002469 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 935591002470 CMP-binding site; other site 935591002471 The sites determining sugar specificity; other site 935591002472 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 935591002473 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 935591002474 RNA binding surface [nucleotide binding]; other site 935591002475 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 935591002476 active site 935591002477 uracil binding [chemical binding]; other site 935591002478 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 935591002479 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935591002480 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935591002481 catalytic residue [active] 935591002482 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935591002483 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 935591002484 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935591002485 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 935591002486 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 935591002487 DNA binding site [nucleotide binding] 935591002488 catalytic residue [active] 935591002489 H2TH interface [polypeptide binding]; other site 935591002490 putative catalytic residues [active] 935591002491 turnover-facilitating residue; other site 935591002492 intercalation triad [nucleotide binding]; other site 935591002493 8OG recognition residue [nucleotide binding]; other site 935591002494 putative reading head residues; other site 935591002495 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 935591002496 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 935591002497 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 935591002498 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 935591002499 putative acyl-acceptor binding pocket; other site 935591002500 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 935591002501 ATP cone domain; Region: ATP-cone; pfam03477 935591002502 Class I ribonucleotide reductase; Region: RNR_I; cd01679 935591002503 active site 935591002504 dimer interface [polypeptide binding]; other site 935591002505 catalytic residues [active] 935591002506 effector binding site; other site 935591002507 R2 peptide binding site; other site 935591002508 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935591002509 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 935591002510 cofactor binding site; other site 935591002511 DNA binding site [nucleotide binding] 935591002512 substrate interaction site [chemical binding]; other site 935591002513 N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016 935591002514 DNA binding site [nucleotide binding] 935591002515 EcoRII C terminal; Region: EcoRII-C; pfam09019 935591002516 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 935591002517 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 935591002518 dimer interface [polypeptide binding]; other site 935591002519 putative radical transfer pathway; other site 935591002520 diiron center [ion binding]; other site 935591002521 tyrosyl radical; other site 935591002522 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 935591002523 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935591002524 catalytic loop [active] 935591002525 iron binding site [ion binding]; other site 935591002526 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 935591002527 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 935591002528 enolase; Provisional; Region: eno; PRK00077 935591002529 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 935591002530 dimer interface [polypeptide binding]; other site 935591002531 metal binding site [ion binding]; metal-binding site 935591002532 substrate binding pocket [chemical binding]; other site 935591002533 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 935591002534 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 935591002535 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 935591002536 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 935591002537 tetramerization interface [polypeptide binding]; other site 935591002538 active site 935591002539 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 935591002540 DEAD-like helicases superfamily; Region: DEXDc; smart00487 935591002541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935591002542 ATP binding site [chemical binding]; other site 935591002543 putative Mg++ binding site [ion binding]; other site 935591002544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935591002545 nucleotide binding region [chemical binding]; other site 935591002546 ATP-binding site [chemical binding]; other site 935591002547 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 935591002548 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 935591002549 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 935591002550 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 935591002551 active site 935591002552 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 935591002553 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935591002554 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935591002555 Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389 935591002556 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 935591002557 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 935591002558 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 935591002559 acyl-activating enzyme (AAE) consensus motif; other site 935591002560 putative AMP binding site [chemical binding]; other site 935591002561 putative active site [active] 935591002562 putative CoA binding site [chemical binding]; other site 935591002563 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 935591002564 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 935591002565 active site 935591002566 oxyanion hole [active] 935591002567 catalytic triad [active] 935591002568 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 935591002569 active site 935591002570 catalytic triad [active] 935591002571 oxyanion hole [active] 935591002572 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 935591002573 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935591002574 metal-binding site [ion binding] 935591002575 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 935591002576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591002577 S-adenosylmethionine binding site [chemical binding]; other site 935591002578 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 935591002579 glycerate kinase; Region: TIGR00045 935591002580 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 935591002581 Low molecular weight phosphatase family; Region: LMWPc; cd00115 935591002582 active site 935591002583 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 935591002584 metal binding site 2 [ion binding]; metal-binding site 935591002585 putative DNA binding helix; other site 935591002586 metal binding site 1 [ion binding]; metal-binding site 935591002587 dimer interface [polypeptide binding]; other site 935591002588 structural Zn2+ binding site [ion binding]; other site 935591002589 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 935591002590 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 935591002591 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 935591002592 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 935591002593 substrate binding site [chemical binding]; other site 935591002594 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 935591002595 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 935591002596 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 935591002597 Ligand Binding Site [chemical binding]; other site 935591002598 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 935591002599 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 935591002600 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 935591002601 homotrimer interaction site [polypeptide binding]; other site 935591002602 putative active site [active] 935591002603 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 935591002604 putative deacylase active site [active] 935591002605 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 935591002606 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935591002607 HSP70 interaction site [polypeptide binding]; other site 935591002608 Predicted membrane protein [Function unknown]; Region: COG3671 935591002609 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 935591002610 Aspartase; Region: Aspartase; cd01357 935591002611 active sites [active] 935591002612 tetramer interface [polypeptide binding]; other site 935591002613 Uncharacterized conserved protein [Function unknown]; Region: COG2353 935591002614 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 935591002615 tartrate dehydrogenase; Region: TTC; TIGR02089 935591002616 NgoBV restriction endonuclease; Region: RE_NgoBV; pfam09564 935591002617 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935591002618 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 935591002619 cofactor binding site; other site 935591002620 DNA binding site [nucleotide binding] 935591002621 substrate interaction site [chemical binding]; other site 935591002622 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935591002623 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 935591002624 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 935591002625 substrate binding site [chemical binding]; other site 935591002626 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 935591002627 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 935591002628 substrate binding site [chemical binding]; other site 935591002629 ligand binding site [chemical binding]; other site 935591002630 Glutamate-cysteine ligase; Region: GshA; pfam08886 935591002631 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 935591002632 hypothetical protein; Reviewed; Region: PRK00024 935591002633 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 935591002634 MPN+ (JAMM) motif; other site 935591002635 Zinc-binding site [ion binding]; other site 935591002636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 935591002637 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 935591002638 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 935591002639 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 935591002640 HflX GTPase family; Region: HflX; cd01878 935591002641 G1 box; other site 935591002642 GTP/Mg2+ binding site [chemical binding]; other site 935591002643 Switch I region; other site 935591002644 G2 box; other site 935591002645 G3 box; other site 935591002646 Switch II region; other site 935591002647 G4 box; other site 935591002648 G5 box; other site 935591002649 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 935591002650 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 935591002651 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935591002652 metal-binding site [ion binding] 935591002653 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 935591002654 Soluble P-type ATPase [General function prediction only]; Region: COG4087 935591002655 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 935591002656 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 935591002657 FAD binding pocket [chemical binding]; other site 935591002658 FAD binding motif [chemical binding]; other site 935591002659 phosphate binding motif [ion binding]; other site 935591002660 beta-alpha-beta structure motif; other site 935591002661 NAD binding pocket [chemical binding]; other site 935591002662 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 935591002663 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 935591002664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591002665 catalytic residue [active] 935591002666 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 935591002667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935591002668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935591002669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 935591002670 dimerization interface [polypeptide binding]; other site 935591002671 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935591002672 Helix-turn-helix domain; Region: HTH_38; pfam13936 935591002673 Homeodomain-like domain; Region: HTH_32; pfam13565 935591002674 Integrase core domain; Region: rve; pfam00665 935591002675 recombination factor protein RarA; Reviewed; Region: PRK13342 935591002676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591002677 Walker A motif; other site 935591002678 ATP binding site [chemical binding]; other site 935591002679 Walker B motif; other site 935591002680 arginine finger; other site 935591002681 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 935591002682 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 935591002683 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 935591002684 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 935591002685 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 935591002686 dimerization interface [polypeptide binding]; other site 935591002687 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 935591002688 dimerization interface [polypeptide binding]; other site 935591002689 active site 935591002690 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 935591002691 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 935591002692 dimerization interface [polypeptide binding]; other site 935591002693 putative ATP binding site [chemical binding]; other site 935591002694 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 935591002695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935591002696 active site 935591002697 phosphorylation site [posttranslational modification] 935591002698 intermolecular recognition site; other site 935591002699 dimerization interface [polypeptide binding]; other site 935591002700 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 935591002701 DNA binding residues [nucleotide binding] 935591002702 dimerization interface [polypeptide binding]; other site 935591002703 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 935591002704 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 935591002705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935591002706 dimerization interface [polypeptide binding]; other site 935591002707 Histidine kinase; Region: HisKA_3; pfam07730 935591002708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935591002709 ATP binding site [chemical binding]; other site 935591002710 Mg2+ binding site [ion binding]; other site 935591002711 G-X-G motif; other site 935591002712 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 935591002713 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 935591002714 GTP binding site; other site 935591002715 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 935591002716 Lumazine binding domain; Region: Lum_binding; pfam00677 935591002717 Lumazine binding domain; Region: Lum_binding; pfam00677 935591002718 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 935591002719 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 935591002720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591002721 Walker A motif; other site 935591002722 ATP binding site [chemical binding]; other site 935591002723 Walker B motif; other site 935591002724 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678 935591002725 dimer interface [polypeptide binding]; other site 935591002726 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 935591002727 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 935591002728 substrate binding site [chemical binding]; other site 935591002729 hexamer interface [polypeptide binding]; other site 935591002730 metal binding site [ion binding]; metal-binding site 935591002731 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 935591002732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591002733 Walker A motif; other site 935591002734 ATP binding site [chemical binding]; other site 935591002735 Walker B motif; other site 935591002736 arginine finger; other site 935591002737 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 935591002738 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 935591002739 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 935591002740 active site 935591002741 NTP binding site [chemical binding]; other site 935591002742 metal binding triad [ion binding]; metal-binding site 935591002743 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 935591002744 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935591002745 Zn2+ binding site [ion binding]; other site 935591002746 Mg2+ binding site [ion binding]; other site 935591002747 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 935591002748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935591002749 Walker A/P-loop; other site 935591002750 ATP binding site [chemical binding]; other site 935591002751 ABC transporter signature motif; other site 935591002752 Walker B; other site 935591002753 D-loop; other site 935591002754 H-loop/switch region; other site 935591002755 ABC transporter; Region: ABC_tran_2; pfam12848 935591002756 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935591002757 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 935591002758 ArsC family; Region: ArsC; pfam03960 935591002759 putative catalytic residues [active] 935591002760 SurA N-terminal domain; Region: SurA_N_3; cl07813 935591002761 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 935591002762 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 935591002763 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 935591002764 RecR protein; Region: RecR; pfam02132 935591002765 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 935591002766 putative active site [active] 935591002767 putative metal-binding site [ion binding]; other site 935591002768 tetramer interface [polypeptide binding]; other site 935591002769 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 935591002770 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 935591002771 FtsX-like permease family; Region: FtsX; pfam02687 935591002772 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 935591002773 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 935591002774 Walker A/P-loop; other site 935591002775 ATP binding site [chemical binding]; other site 935591002776 Q-loop/lid; other site 935591002777 ABC transporter signature motif; other site 935591002778 Walker B; other site 935591002779 D-loop; other site 935591002780 H-loop/switch region; other site 935591002781 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 935591002782 AAA domain; Region: AAA_30; pfam13604 935591002783 Family description; Region: UvrD_C_2; pfam13538 935591002784 Methyltransferase domain; Region: Methyltransf_23; pfam13489 935591002785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591002786 S-adenosylmethionine binding site [chemical binding]; other site 935591002787 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 935591002788 Found in ATP-dependent protease La (LON); Region: LON; smart00464 935591002789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591002790 Walker A motif; other site 935591002791 ATP binding site [chemical binding]; other site 935591002792 Walker B motif; other site 935591002793 arginine finger; other site 935591002794 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 935591002795 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 935591002796 IHF dimer interface [polypeptide binding]; other site 935591002797 IHF - DNA interface [nucleotide binding]; other site 935591002798 homoserine dehydrogenase; Provisional; Region: PRK06349 935591002799 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 935591002800 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 935591002801 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 935591002802 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 935591002803 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 935591002804 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935591002805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935591002806 ABC transporter; Region: ABC_tran_2; pfam12848 935591002807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935591002808 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 935591002809 ligand binding site [chemical binding]; other site 935591002810 active site 935591002811 UGI interface [polypeptide binding]; other site 935591002812 catalytic site [active] 935591002813 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 935591002814 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 935591002815 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 935591002816 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 935591002817 Domain of unknown function DUF20; Region: UPF0118; pfam01594 935591002818 Uncharacterized conserved protein [Function unknown]; Region: COG2921 935591002819 lipoate-protein ligase B; Provisional; Region: PRK14342 935591002820 lipoyl synthase; Provisional; Region: PRK05481 935591002821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935591002822 FeS/SAM binding site; other site 935591002823 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 935591002824 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 935591002825 heme binding site [chemical binding]; other site 935591002826 ferroxidase pore; other site 935591002827 ferroxidase diiron center [ion binding]; other site 935591002828 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 935591002829 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 935591002830 heme binding site [chemical binding]; other site 935591002831 ferroxidase pore; other site 935591002832 ferroxidase diiron center [ion binding]; other site 935591002833 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 935591002834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935591002835 non-specific DNA binding site [nucleotide binding]; other site 935591002836 salt bridge; other site 935591002837 sequence-specific DNA binding site [nucleotide binding]; other site 935591002838 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 935591002839 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935591002840 metal binding triad; other site 935591002841 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 935591002842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935591002843 Zn2+ binding site [ion binding]; other site 935591002844 Mg2+ binding site [ion binding]; other site 935591002845 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 935591002846 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 935591002847 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 935591002848 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935591002849 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 935591002850 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 935591002851 active site 935591002852 ribonuclease R; Region: RNase_R; TIGR02063 935591002853 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 935591002854 RNB domain; Region: RNB; pfam00773 935591002855 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 935591002856 RNA binding site [nucleotide binding]; other site 935591002857 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 935591002858 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 935591002859 G1 box; other site 935591002860 putative GEF interaction site [polypeptide binding]; other site 935591002861 GTP/Mg2+ binding site [chemical binding]; other site 935591002862 Switch I region; other site 935591002863 G2 box; other site 935591002864 G3 box; other site 935591002865 Switch II region; other site 935591002866 G4 box; other site 935591002867 G5 box; other site 935591002868 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 935591002869 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 935591002870 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 935591002871 putative substrate binding site [chemical binding]; other site 935591002872 putative ATP binding site [chemical binding]; other site 935591002873 Cytochrome b [Energy production and conversion]; Region: COG3658 935591002874 siroheme synthase; Provisional; Region: cysG; PRK10637 935591002875 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 935591002876 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 935591002877 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 935591002878 active site 935591002879 SAM binding site [chemical binding]; other site 935591002880 homodimer interface [polypeptide binding]; other site 935591002881 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 935591002882 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 935591002883 Active Sites [active] 935591002884 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 935591002885 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 935591002886 Active Sites [active] 935591002887 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 935591002888 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 935591002889 CysD dimerization site [polypeptide binding]; other site 935591002890 G1 box; other site 935591002891 putative GEF interaction site [polypeptide binding]; other site 935591002892 GTP/Mg2+ binding site [chemical binding]; other site 935591002893 Switch I region; other site 935591002894 G2 box; other site 935591002895 G3 box; other site 935591002896 Switch II region; other site 935591002897 G4 box; other site 935591002898 G5 box; other site 935591002899 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 935591002900 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 935591002901 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 935591002902 Flavodoxin; Region: Flavodoxin_1; pfam00258 935591002903 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 935591002904 FAD binding pocket [chemical binding]; other site 935591002905 FAD binding motif [chemical binding]; other site 935591002906 catalytic residues [active] 935591002907 NAD binding pocket [chemical binding]; other site 935591002908 phosphate binding motif [ion binding]; other site 935591002909 beta-alpha-beta structure motif; other site 935591002910 sulfite reductase subunit beta; Provisional; Region: PRK13504 935591002911 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 935591002912 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 935591002913 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 935591002914 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 935591002915 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 935591002916 biotin synthase; Region: bioB; TIGR00433 935591002917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935591002918 FeS/SAM binding site; other site 935591002919 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 935591002920 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 935591002921 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935591002922 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935591002923 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 935591002924 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 935591002925 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 935591002926 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 935591002927 Ligand Binding Site [chemical binding]; other site 935591002928 TilS substrate binding domain; Region: TilS; pfam09179 935591002929 TilS substrate C-terminal domain; Region: TilS_C; cl17443 935591002930 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 935591002931 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 935591002932 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935591002933 RNA binding surface [nucleotide binding]; other site 935591002934 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 935591002935 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 935591002936 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935591002937 catalytic loop [active] 935591002938 iron binding site [ion binding]; other site 935591002939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 935591002940 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 935591002941 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 935591002942 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 935591002943 chaperone protein HscA; Provisional; Region: hscA; PRK05183 935591002944 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 935591002945 nucleotide binding site [chemical binding]; other site 935591002946 putative NEF/HSP70 interaction site [polypeptide binding]; other site 935591002947 SBD interface [polypeptide binding]; other site 935591002948 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 935591002949 active site lid residues [active] 935591002950 substrate binding pocket [chemical binding]; other site 935591002951 catalytic residues [active] 935591002952 substrate-Mg2+ binding site; other site 935591002953 aspartate-rich region 1; other site 935591002954 aspartate-rich region 2; other site 935591002955 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 935591002956 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 935591002957 short chain dehydrogenase; Provisional; Region: PRK08703 935591002958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935591002959 NAD(P) binding site [chemical binding]; other site 935591002960 active site 935591002961 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 935591002962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 935591002963 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 935591002964 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 935591002965 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 935591002966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 935591002967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 935591002968 Phage Tail Collar Domain; Region: Collar; pfam07484 935591002969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 935591002970 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 935591002971 Mu-like prophage protein gp46 [Function unknown]; Region: COG4381 935591002972 Mu-like prophage protein gp45 [Function unknown]; Region: COG4384 935591002973 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 935591002974 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 935591002975 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 935591002976 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 935591002977 Mu-like prophage I protein [General function prediction only]; Region: COG4388 935591002978 Mu-like prophage protein gpG [General function prediction only]; Region: COG5005 935591002979 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 935591002980 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 935591002981 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 935591002982 Protein of unknown function (DUF935); Region: DUF935; pfam06074 935591002983 phage uncharacterized protein (putative large terminase), C-terminal domain; Region: psiM2_ORF9; TIGR01630 935591002984 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 935591002985 Uncharacterized conserved protein [Function unknown]; Region: COG3422 935591002986 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 935591002987 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 935591002988 active site 935591002989 metal binding site [ion binding]; metal-binding site 935591002990 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 935591002991 AAA domain; Region: AAA_22; pfam13401 935591002992 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 935591002993 Mor transcription activator family; Region: Mor; cl02360 935591002994 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 935591002995 Integrase core domain; Region: rve; pfam00665 935591002996 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 935591002997 Predicted transcriptional regulator [Transcription]; Region: COG2932 935591002998 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935591002999 Catalytic site [active] 935591003000 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 935591003001 ABC transporter; Region: ABC_tran; pfam00005 935591003002 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 935591003003 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 935591003004 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 935591003005 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 935591003006 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 935591003007 feedback inhibition sensing region; other site 935591003008 homohexameric interface [polypeptide binding]; other site 935591003009 nucleotide binding site [chemical binding]; other site 935591003010 N-acetyl-L-glutamate binding site [chemical binding]; other site 935591003011 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 935591003012 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 935591003013 putative active site [active] 935591003014 Zn binding site [ion binding]; other site 935591003015 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 935591003016 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 935591003017 yecA family protein; Region: ygfB_yecA; TIGR02292 935591003018 SEC-C motif; Region: SEC-C; pfam02810 935591003019 2-isopropylmalate synthase; Validated; Region: PRK00915 935591003020 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 935591003021 active site 935591003022 catalytic residues [active] 935591003023 metal binding site [ion binding]; metal-binding site 935591003024 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 935591003025 glutamate 5-kinase; Region: proB; TIGR01027 935591003026 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 935591003027 nucleotide binding site [chemical binding]; other site 935591003028 homotetrameric interface [polypeptide binding]; other site 935591003029 putative phosphate binding site [ion binding]; other site 935591003030 putative allosteric binding site; other site 935591003031 PUA domain; Region: PUA; pfam01472 935591003032 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 935591003033 putative catalytic cysteine [active] 935591003034 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 935591003035 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 935591003036 Predicted membrane protein [Function unknown]; Region: COG3235 935591003037 camphor resistance protein CrcB; Provisional; Region: PRK14230 935591003038 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 935591003039 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 935591003040 dimer interface [polypeptide binding]; other site 935591003041 ADP-ribose binding site [chemical binding]; other site 935591003042 active site 935591003043 nudix motif; other site 935591003044 metal binding site [ion binding]; metal-binding site 935591003045 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 935591003046 active site 935591003047 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 935591003048 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 935591003049 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 935591003050 AMP binding site [chemical binding]; other site 935591003051 metal binding site [ion binding]; metal-binding site 935591003052 active site 935591003053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 935591003054 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 935591003055 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 935591003056 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 935591003057 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 935591003058 dimer interface [polypeptide binding]; other site 935591003059 active site 935591003060 glycine-pyridoxal phosphate binding site [chemical binding]; other site 935591003061 folate binding site [chemical binding]; other site 935591003062 Transposase domain (DUF772); Region: DUF772; pfam05598 935591003063 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591003064 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935591003065 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935591003066 Outer membrane protein OpcA; Region: OpcA; pfam07239 935591003067 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 935591003068 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 935591003069 ABC transporter ATPase component; Reviewed; Region: PRK11147 935591003070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935591003071 Walker A/P-loop; other site 935591003072 ATP binding site [chemical binding]; other site 935591003073 Q-loop/lid; other site 935591003074 ABC transporter signature motif; other site 935591003075 Walker B; other site 935591003076 D-loop; other site 935591003077 H-loop/switch region; other site 935591003078 ABC transporter; Region: ABC_tran_2; pfam12848 935591003079 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935591003080 anthranilate synthase component I; Provisional; Region: PRK13565 935591003081 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 935591003082 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 935591003083 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 935591003084 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 935591003085 XdhC Rossmann domain; Region: XdhC_C; pfam13478 935591003086 ATP-grasp domain; Region: ATP-grasp; pfam02222 935591003087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 935591003088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935591003089 Coenzyme A binding pocket [chemical binding]; other site 935591003090 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 935591003091 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 935591003092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 935591003093 Smr domain; Region: Smr; pfam01713 935591003094 HTH-like domain; Region: HTH_21; pfam13276 935591003095 Integrase core domain; Region: rve; pfam00665 935591003096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 935591003097 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 935591003098 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 935591003099 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 935591003100 Predicted transcriptional regulator [Transcription]; Region: COG2932 935591003101 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935591003102 Catalytic site [active] 935591003103 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 935591003104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935591003105 non-specific DNA binding site [nucleotide binding]; other site 935591003106 salt bridge; other site 935591003107 sequence-specific DNA binding site [nucleotide binding]; other site 935591003108 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 935591003109 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 935591003110 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 935591003111 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 935591003112 Transposase domain (DUF772); Region: DUF772; pfam05598 935591003113 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591003114 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935591003115 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 935591003116 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 935591003117 FMN binding site [chemical binding]; other site 935591003118 active site 935591003119 catalytic residues [active] 935591003120 substrate binding site [chemical binding]; other site 935591003121 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 935591003122 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 935591003123 FAD binding domain; Region: FAD_binding_4; pfam01565 935591003124 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 935591003125 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 935591003126 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 935591003127 Cysteine-rich domain; Region: CCG; pfam02754 935591003128 Cysteine-rich domain; Region: CCG; pfam02754 935591003129 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 935591003130 D-lactate dehydrogenase; Provisional; Region: PRK11183 935591003131 FAD binding domain; Region: FAD_binding_4; pfam01565 935591003132 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 935591003133 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 935591003134 Uncharacterized conserved protein [Function unknown]; Region: COG2128 935591003135 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 935591003136 Rubredoxin [Energy production and conversion]; Region: COG1773 935591003137 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 935591003138 iron binding site [ion binding]; other site 935591003139 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 935591003140 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 935591003141 YadA-like C-terminal region; Region: YadA; pfam03895 935591003142 Transposase domain (DUF772); Region: DUF772; pfam05598 935591003143 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591003144 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935591003145 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 935591003146 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 935591003147 active site 935591003148 metal binding site [ion binding]; metal-binding site 935591003149 Mor transcription activator family; Region: Mor; cl02360 935591003150 Mu-like prophage protein gp16 [Function unknown]; Region: COG4382 935591003151 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 935591003152 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 935591003153 purine monophosphate binding site [chemical binding]; other site 935591003154 dimer interface [polypeptide binding]; other site 935591003155 putative catalytic residues [active] 935591003156 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 935591003157 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 935591003158 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 935591003159 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 935591003160 putative ion selectivity filter; other site 935591003161 putative pore gating glutamate residue; other site 935591003162 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 935591003163 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 935591003164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935591003165 motif II; other site 935591003166 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 935591003167 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 935591003168 ligand binding site [chemical binding]; other site 935591003169 homodimer interface [polypeptide binding]; other site 935591003170 NAD(P) binding site [chemical binding]; other site 935591003171 trimer interface B [polypeptide binding]; other site 935591003172 trimer interface A [polypeptide binding]; other site 935591003173 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 935591003174 Predicted membrane protein [Function unknown]; Region: COG3686 935591003175 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 935591003176 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 935591003177 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 935591003178 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935591003179 Protein of unknown function (DUF1132); Region: DUF1132; pfam06575 935591003180 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935591003181 Replication initiation factor; Region: Rep_trans; pfam02486 935591003182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935591003183 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 935591003184 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 935591003185 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 935591003186 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 935591003187 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 935591003188 glutamine binding [chemical binding]; other site 935591003189 catalytic triad [active] 935591003190 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 935591003191 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 935591003192 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935591003193 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 935591003194 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 935591003195 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 935591003196 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 935591003197 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 935591003198 Predicted transcriptional regulator [Transcription]; Region: COG2378 935591003199 WYL domain; Region: WYL; pfam13280 935591003200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 935591003201 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 935591003202 CoA binding domain; Region: CoA_binding; smart00881 935591003203 CoA-ligase; Region: Ligase_CoA; pfam00549 935591003204 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 935591003205 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 935591003206 CoA-ligase; Region: Ligase_CoA; pfam00549 935591003207 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 935591003208 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 935591003209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935591003210 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935591003211 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 935591003212 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935591003213 E3 interaction surface; other site 935591003214 lipoyl attachment site [posttranslational modification]; other site 935591003215 e3 binding domain; Region: E3_binding; pfam02817 935591003216 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 935591003217 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 935591003218 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 935591003219 TPP-binding site [chemical binding]; other site 935591003220 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 935591003221 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 935591003222 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 935591003223 dimer interface [polypeptide binding]; other site 935591003224 active site 935591003225 citrylCoA binding site [chemical binding]; other site 935591003226 NADH binding [chemical binding]; other site 935591003227 cationic pore residues; other site 935591003228 oxalacetate/citrate binding site [chemical binding]; other site 935591003229 coenzyme A binding site [chemical binding]; other site 935591003230 catalytic triad [active] 935591003231 Uncharacterized conserved protein [Function unknown]; Region: COG2938 935591003232 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 935591003233 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 935591003234 succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; Region: sdhA_forward; TIGR01816 935591003235 L-aspartate oxidase; Provisional; Region: PRK06175 935591003236 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 935591003237 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 935591003238 SdhC subunit interface [polypeptide binding]; other site 935591003239 proximal heme binding site [chemical binding]; other site 935591003240 cardiolipin binding site; other site 935591003241 Iron-sulfur protein interface; other site 935591003242 proximal quinone binding site [chemical binding]; other site 935591003243 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 935591003244 Iron-sulfur protein interface; other site 935591003245 proximal quinone binding site [chemical binding]; other site 935591003246 SdhD (CybS) interface [polypeptide binding]; other site 935591003247 proximal heme binding site [chemical binding]; other site 935591003248 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 935591003249 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935591003250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935591003251 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935591003252 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 935591003253 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 935591003254 catalytic triad [active] 935591003255 dimer interface [polypeptide binding]; other site 935591003256 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 935591003257 GSH binding site [chemical binding]; other site 935591003258 catalytic residues [active] 935591003259 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 935591003260 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 935591003261 THF binding site; other site 935591003262 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 935591003263 substrate binding site [chemical binding]; other site 935591003264 THF binding site; other site 935591003265 zinc-binding site [ion binding]; other site 935591003266 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 935591003267 FAD binding site [chemical binding]; other site 935591003268 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 935591003269 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 935591003270 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 935591003271 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 935591003272 Methyltransferase domain; Region: Methyltransf_23; pfam13489 935591003273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591003274 S-adenosylmethionine binding site [chemical binding]; other site 935591003275 elongation factor P; Validated; Region: PRK00529 935591003276 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 935591003277 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 935591003278 RNA binding site [nucleotide binding]; other site 935591003279 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 935591003280 RNA binding site [nucleotide binding]; other site 935591003281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 935591003282 conserved hypothetical protein, PP_1857 family; Region: efp_adjacent_2; TIGR03837 935591003283 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 935591003284 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 935591003285 TfoX N-terminal domain; Region: TfoX_N; cl17592 935591003286 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 935591003287 nucleoside/Zn binding site; other site 935591003288 dimer interface [polypeptide binding]; other site 935591003289 catalytic motif [active] 935591003290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 935591003291 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 935591003292 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 935591003293 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 935591003294 xanthine permease; Region: pbuX; TIGR03173 935591003295 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 935591003296 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 935591003297 dimer interface [polypeptide binding]; other site 935591003298 active site 935591003299 catalytic residue [active] 935591003300 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 935591003301 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 935591003302 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935591003303 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 935591003304 malonic semialdehyde reductase; Provisional; Region: PRK10538 935591003305 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 935591003306 putative NAD(P) binding site [chemical binding]; other site 935591003307 homotetramer interface [polypeptide binding]; other site 935591003308 homodimer interface [polypeptide binding]; other site 935591003309 active site 935591003310 Cytochrome C' Region: Cytochrom_C_2; cl01610 935591003311 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 935591003312 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 935591003313 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 935591003314 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 935591003315 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 935591003316 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 935591003317 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 935591003318 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935591003319 Helix-turn-helix domain; Region: HTH_38; pfam13936 935591003320 Homeodomain-like domain; Region: HTH_32; pfam13565 935591003321 Integrase core domain; Region: rve; pfam00665 935591003322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935591003323 non-specific DNA binding site [nucleotide binding]; other site 935591003324 Predicted transcriptional regulator [Transcription]; Region: COG2932 935591003325 salt bridge; other site 935591003326 sequence-specific DNA binding site [nucleotide binding]; other site 935591003327 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935591003328 Catalytic site [active] 935591003329 Uncharacterized conserved protein [Function unknown]; Region: COG5532 935591003330 Predicted helicase [General function prediction only]; Region: COG4889 935591003331 KilA-N domain; Region: KilA-N; pfam04383 935591003332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 935591003333 integrase; Provisional; Region: PRK09692 935591003334 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 935591003335 active site 935591003336 Int/Topo IB signature motif; other site 935591003337 hypothetical protein; Validated; Region: PRK02101 935591003338 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 935591003339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935591003340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591003341 homodimer interface [polypeptide binding]; other site 935591003342 catalytic residue [active] 935591003343 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 935591003344 trimer interface [polypeptide binding]; other site 935591003345 active site 935591003346 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935591003347 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 935591003348 Minor type IV pilin, PilX; Region: Pilin_PilX; pfam11530 935591003349 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 935591003350 PilX N-terminal; Region: PilX_N; pfam14341 935591003351 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 935591003352 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 935591003353 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 935591003354 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 935591003355 Type II transport protein GspH; Region: GspH; pfam12019 935591003356 replicative DNA helicase; Region: DnaB; TIGR00665 935591003357 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 935591003358 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 935591003359 Walker A motif; other site 935591003360 ATP binding site [chemical binding]; other site 935591003361 Walker B motif; other site 935591003362 DNA binding loops [nucleotide binding] 935591003363 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 935591003364 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 935591003365 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 935591003366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 935591003367 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 935591003368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935591003369 dimer interface [polypeptide binding]; other site 935591003370 conserved gate region; other site 935591003371 putative PBP binding loops; other site 935591003372 ABC-ATPase subunit interface; other site 935591003373 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 935591003374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935591003375 dimer interface [polypeptide binding]; other site 935591003376 conserved gate region; other site 935591003377 putative PBP binding loops; other site 935591003378 ABC-ATPase subunit interface; other site 935591003379 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 935591003380 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 935591003381 Walker A/P-loop; other site 935591003382 ATP binding site [chemical binding]; other site 935591003383 Q-loop/lid; other site 935591003384 ABC transporter signature motif; other site 935591003385 Walker B; other site 935591003386 D-loop; other site 935591003387 H-loop/switch region; other site 935591003388 threonine dehydratase; Reviewed; Region: PRK09224 935591003389 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 935591003390 tetramer interface [polypeptide binding]; other site 935591003391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591003392 catalytic residue [active] 935591003393 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 935591003394 putative Ile/Val binding site [chemical binding]; other site 935591003395 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 935591003396 putative Ile/Val binding site [chemical binding]; other site 935591003397 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 935591003398 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 935591003399 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 935591003400 Restriction endonuclease [Defense mechanisms]; Region: COG3587 935591003401 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935591003402 ATP binding site [chemical binding]; other site 935591003403 putative Mg++ binding site [ion binding]; other site 935591003404 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 935591003405 DNA methylase; Region: N6_N4_Mtase; pfam01555 935591003406 DNA methylase; Region: N6_N4_Mtase; cl17433 935591003407 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 935591003408 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 935591003409 5S rRNA interface [nucleotide binding]; other site 935591003410 CTC domain interface [polypeptide binding]; other site 935591003411 L16 interface [polypeptide binding]; other site 935591003412 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 935591003413 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 935591003414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935591003415 active site 935591003416 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 935591003417 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 935591003418 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 935591003419 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 935591003420 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 935591003421 TPR repeat; Region: TPR_11; pfam13414 935591003422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935591003423 binding surface 935591003424 TPR motif; other site 935591003425 pantoate--beta-alanine ligase; Region: panC; TIGR00018 935591003426 Pantoate-beta-alanine ligase; Region: PanC; cd00560 935591003427 active site 935591003428 ATP-binding site [chemical binding]; other site 935591003429 pantoate-binding site; other site 935591003430 HXXH motif; other site 935591003431 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 935591003432 oligomerization interface [polypeptide binding]; other site 935591003433 active site 935591003434 metal binding site [ion binding]; metal-binding site 935591003435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591003436 S-adenosylmethionine binding site [chemical binding]; other site 935591003437 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 935591003438 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 935591003439 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 935591003440 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 935591003441 probable active site [active] 935591003442 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 935591003443 putative active site [active] 935591003444 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 935591003445 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 935591003446 dimer interface [polypeptide binding]; other site 935591003447 motif 1; other site 935591003448 active site 935591003449 motif 2; other site 935591003450 motif 3; other site 935591003451 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 935591003452 anticodon binding site; other site 935591003453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 935591003454 GTP-binding protein Der; Reviewed; Region: PRK00093 935591003455 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 935591003456 G1 box; other site 935591003457 GTP/Mg2+ binding site [chemical binding]; other site 935591003458 Switch I region; other site 935591003459 G2 box; other site 935591003460 Switch II region; other site 935591003461 G3 box; other site 935591003462 G4 box; other site 935591003463 G5 box; other site 935591003464 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 935591003465 G1 box; other site 935591003466 GTP/Mg2+ binding site [chemical binding]; other site 935591003467 Switch I region; other site 935591003468 G2 box; other site 935591003469 G3 box; other site 935591003470 Switch II region; other site 935591003471 G4 box; other site 935591003472 G5 box; other site 935591003473 Putative exonuclease, RdgC; Region: RdgC; cl01122 935591003474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 935591003475 MORN repeat; Region: MORN; cl14787 935591003476 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 935591003477 trimer interface [polypeptide binding]; other site 935591003478 active site 935591003479 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3471 935591003480 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 935591003481 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935591003482 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 935591003483 PhoH-like protein; Region: PhoH; pfam02562 935591003484 poly(A) polymerase; Region: pcnB; TIGR01942 935591003485 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 935591003486 active site 935591003487 NTP binding site [chemical binding]; other site 935591003488 metal binding triad [ion binding]; metal-binding site 935591003489 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 935591003490 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 935591003491 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935591003492 Helix-turn-helix domain; Region: HTH_38; pfam13936 935591003493 Homeodomain-like domain; Region: HTH_32; pfam13565 935591003494 Integrase core domain; Region: rve; pfam00665 935591003495 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 935591003496 DHH family; Region: DHH; pfam01368 935591003497 DHHA1 domain; Region: DHHA1; pfam02272 935591003498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 935591003499 peptidase PmbA; Provisional; Region: PRK11040 935591003500 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 935591003501 DNA-binding site [nucleotide binding]; DNA binding site 935591003502 RNA-binding motif; other site 935591003503 Uncharacterized conserved protein [Function unknown]; Region: COG2127 935591003504 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 935591003505 Clp amino terminal domain; Region: Clp_N; pfam02861 935591003506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591003507 Walker A motif; other site 935591003508 ATP binding site [chemical binding]; other site 935591003509 Walker B motif; other site 935591003510 arginine finger; other site 935591003511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591003512 Walker A motif; other site 935591003513 ATP binding site [chemical binding]; other site 935591003514 Walker B motif; other site 935591003515 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 935591003516 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 935591003517 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 935591003518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935591003519 ATP binding site [chemical binding]; other site 935591003520 putative Mg++ binding site [ion binding]; other site 935591003521 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 935591003522 HsdM N-terminal domain; Region: HsdM_N; pfam12161 935591003523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591003524 S-adenosylmethionine binding site [chemical binding]; other site 935591003525 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 935591003526 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 935591003527 NADP binding site [chemical binding]; other site 935591003528 homopentamer interface [polypeptide binding]; other site 935591003529 substrate binding site [chemical binding]; other site 935591003530 active site 935591003531 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 935591003532 HNH endonuclease; Region: HNH_2; pfam13391 935591003533 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 935591003534 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935591003535 cofactor binding site; other site 935591003536 DNA binding site [nucleotide binding] 935591003537 substrate interaction site [chemical binding]; other site 935591003538 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935591003539 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 935591003540 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 935591003541 putative ribose interaction site [chemical binding]; other site 935591003542 putative ADP binding site [chemical binding]; other site 935591003543 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 935591003544 active site 935591003545 dimer interface [polypeptide binding]; other site 935591003546 adenylate kinase; Reviewed; Region: adk; PRK00279 935591003547 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 935591003548 AMP-binding site [chemical binding]; other site 935591003549 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 935591003550 heat shock protein HtpX; Provisional; Region: PRK05457 935591003551 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935591003552 NUMOD1 domain; Region: NUMOD1; pfam07453 935591003553 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935591003554 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 935591003555 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935591003556 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935591003557 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 935591003558 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 935591003559 GDP-binding site [chemical binding]; other site 935591003560 ACT binding site; other site 935591003561 IMP binding site; other site 935591003562 ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705 935591003563 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935591003564 motif 1; other site 935591003565 dimer interface [polypeptide binding]; other site 935591003566 active site 935591003567 motif 2; other site 935591003568 motif 3; other site 935591003569 multidrug efflux protein; Reviewed; Region: PRK01766 935591003570 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 935591003571 cation binding site [ion binding]; other site 935591003572 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 935591003573 FAD binding domain; Region: FAD_binding_4; pfam01565 935591003574 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 935591003575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935591003576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935591003577 Bacterial transcriptional repressor; Region: TetR; pfam13972 935591003578 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 935591003579 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 935591003580 putative NAD(P) binding site [chemical binding]; other site 935591003581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 935591003582 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04539 935591003583 ATP-NAD kinase; Region: NAD_kinase; pfam01513 935591003584 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 935591003585 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935591003586 RNA binding surface [nucleotide binding]; other site 935591003587 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 935591003588 active site 935591003589 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 935591003590 dimer interface [polypeptide binding]; other site 935591003591 FMN binding site [chemical binding]; other site 935591003592 putative GTP cyclohydrolase; Provisional; Region: PRK13674 935591003593 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 935591003594 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 935591003595 homodimer interface [polypeptide binding]; other site 935591003596 substrate-cofactor binding pocket; other site 935591003597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591003598 catalytic residue [active] 935591003599 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 935591003600 dimer interface [polypeptide binding]; other site 935591003601 active site 935591003602 aspartate-rich active site metal binding site; other site 935591003603 allosteric magnesium binding site [ion binding]; other site 935591003604 Schiff base residues; other site 935591003605 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 935591003606 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 935591003607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591003608 S-adenosylmethionine binding site [chemical binding]; other site 935591003609 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 935591003610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935591003611 Walker A motif; other site 935591003612 ATP binding site [chemical binding]; other site 935591003613 Walker B motif; other site 935591003614 arginine finger; other site 935591003615 Peptidase family M41; Region: Peptidase_M41; pfam01434 935591003616 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 935591003617 putative coenzyme Q binding site [chemical binding]; other site 935591003618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 935591003619 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 935591003620 putative active site [active] 935591003621 catalytic residue [active] 935591003622 VanZ like family; Region: VanZ; cl01971 935591003623 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 935591003624 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 935591003625 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 935591003626 active site 935591003627 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 935591003628 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 935591003629 active site 935591003630 substrate binding site [chemical binding]; other site 935591003631 metal binding site [ion binding]; metal-binding site 935591003632 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 935591003633 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 935591003634 Walker A/P-loop; other site 935591003635 ATP binding site [chemical binding]; other site 935591003636 Q-loop/lid; other site 935591003637 ABC transporter signature motif; other site 935591003638 Walker B; other site 935591003639 D-loop; other site 935591003640 H-loop/switch region; other site 935591003641 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 935591003642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935591003643 dimer interface [polypeptide binding]; other site 935591003644 conserved gate region; other site 935591003645 putative PBP binding loops; other site 935591003646 ABC-ATPase subunit interface; other site 935591003647 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 935591003648 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 935591003649 substrate binding pocket [chemical binding]; other site 935591003650 membrane-bound complex binding site; other site 935591003651 hinge residues; other site 935591003652 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 935591003653 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 935591003654 Part of AAA domain; Region: AAA_19; pfam13245 935591003655 Family description; Region: UvrD_C_2; pfam13538 935591003656 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 935591003657 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 935591003658 active site residue [active] 935591003659 Uncharacterized conserved protein [Function unknown]; Region: COG3439 935591003660 DNA repair protein RadA; Provisional; Region: PRK11823 935591003661 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 935591003662 Walker A motif/ATP binding site; other site 935591003663 ATP binding site [chemical binding]; other site 935591003664 Walker B motif; other site 935591003665 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 935591003666 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 935591003667 substrate binding site [chemical binding]; other site 935591003668 active site 935591003669 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 935591003670 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 935591003671 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 935591003672 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 935591003673 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 935591003674 active site 935591003675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4390 935591003676 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935591003677 active site 935591003678 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 935591003679 putative GSH binding site [chemical binding]; other site 935591003680 catalytic residues [active] 935591003681 Domain of unknown function (DUF333); Region: DUF333; pfam03891 935591003682 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 935591003683 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 935591003684 active site 935591003685 Tfp pilus assembly protein PilZ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilZ; COG3215 935591003686 DNA polymerase III subunit delta'; Validated; Region: PRK08699 935591003687 DNA polymerase III subunit delta'; Validated; Region: PRK08485 935591003688 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 935591003689 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 935591003690 Walker A motif; other site 935591003691 ATP binding site [chemical binding]; other site 935591003692 Walker B motif; other site 935591003693 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 935591003694 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 935591003695 GTP-binding protein LepA; Provisional; Region: PRK05433 935591003696 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 935591003697 G1 box; other site 935591003698 putative GEF interaction site [polypeptide binding]; other site 935591003699 GTP/Mg2+ binding site [chemical binding]; other site 935591003700 Switch I region; other site 935591003701 G2 box; other site 935591003702 G3 box; other site 935591003703 Switch II region; other site 935591003704 G4 box; other site 935591003705 G5 box; other site 935591003706 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 935591003707 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 935591003708 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 935591003709 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 935591003710 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 935591003711 Catalytic site [active] 935591003712 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 935591003713 EamA-like transporter family; Region: EamA; pfam00892 935591003714 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 935591003715 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 935591003716 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 935591003717 dimer interface [polypeptide binding]; other site 935591003718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591003719 catalytic residue [active] 935591003720 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 935591003721 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 935591003722 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 935591003723 Uncharacterized conserved protein [Function unknown]; Region: COG2836 935591003724 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 935591003725 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 935591003726 RNase E interface [polypeptide binding]; other site 935591003727 trimer interface [polypeptide binding]; other site 935591003728 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 935591003729 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 935591003730 RNase E interface [polypeptide binding]; other site 935591003731 trimer interface [polypeptide binding]; other site 935591003732 active site 935591003733 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 935591003734 putative nucleic acid binding region [nucleotide binding]; other site 935591003735 G-X-X-G motif; other site 935591003736 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 935591003737 RNA binding site [nucleotide binding]; other site 935591003738 domain interface; other site 935591003739 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 935591003740 ATP binding site [chemical binding]; other site 935591003741 active site 935591003742 substrate binding site [chemical binding]; other site 935591003743 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 935591003744 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 935591003745 NADP binding site [chemical binding]; other site 935591003746 active site 935591003747 putative substrate binding site [chemical binding]; other site 935591003748 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 935591003749 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 935591003750 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 935591003751 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 935591003752 active site 935591003753 Int/Topo IB signature motif; other site 935591003754 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 935591003755 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 935591003756 catalytic triad [active] 935591003757 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 935591003758 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 935591003759 bacterial Hfq-like; Region: Hfq; cd01716 935591003760 hexamer interface [polypeptide binding]; other site 935591003761 Sm1 motif; other site 935591003762 RNA binding site [nucleotide binding]; other site 935591003763 Sm2 motif; other site 935591003764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591003765 S-adenosylmethionine binding site [chemical binding]; other site 935591003766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094 935591003767 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 935591003768 catalytic center binding site [active] 935591003769 ATP binding site [chemical binding]; other site 935591003770 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 935591003771 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 935591003772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591003773 S-adenosylmethionine binding site [chemical binding]; other site 935591003774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 935591003775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 935591003776 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 935591003777 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 935591003778 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 935591003779 Walker A/P-loop; other site 935591003780 ATP binding site [chemical binding]; other site 935591003781 Q-loop/lid; other site 935591003782 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 935591003783 ABC transporter signature motif; other site 935591003784 Walker B; other site 935591003785 D-loop; other site 935591003786 H-loop/switch region; other site 935591003787 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 935591003788 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 935591003789 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 935591003790 GTP/Mg2+ binding site [chemical binding]; other site 935591003791 G4 box; other site 935591003792 G5 box; other site 935591003793 G1 box; other site 935591003794 Switch I region; other site 935591003795 G2 box; other site 935591003796 G3 box; other site 935591003797 Switch II region; other site 935591003798 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 935591003799 HPr kinase/phosphorylase; Provisional; Region: PRK05428 935591003800 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 935591003801 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 935591003802 Hpr binding site; other site 935591003803 active site 935591003804 homohexamer subunit interaction site [polypeptide binding]; other site 935591003805 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 935591003806 active site 935591003807 phosphorylation site [posttranslational modification] 935591003808 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 935591003809 UbiA prenyltransferase family; Region: UbiA; pfam01040 935591003810 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 935591003811 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 935591003812 AAA domain; Region: AAA_26; pfam13500 935591003813 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 935591003814 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935591003815 inhibitor-cofactor binding pocket; inhibition site 935591003816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591003817 catalytic residue [active] 935591003818 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 935591003819 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 935591003820 IHF - DNA interface [nucleotide binding]; other site 935591003821 IHF dimer interface [polypeptide binding]; other site 935591003822 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 935591003823 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 935591003824 putative tRNA-binding site [nucleotide binding]; other site 935591003825 B3/4 domain; Region: B3_4; pfam03483 935591003826 tRNA synthetase B5 domain; Region: B5; smart00874 935591003827 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 935591003828 dimer interface [polypeptide binding]; other site 935591003829 motif 1; other site 935591003830 motif 3; other site 935591003831 motif 2; other site 935591003832 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 935591003833 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 935591003834 DNA methylase; Region: N6_N4_Mtase; cl17433 935591003835 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 935591003836 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 935591003837 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 935591003838 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935591003839 cofactor binding site; other site 935591003840 DNA binding site [nucleotide binding] 935591003841 substrate interaction site [chemical binding]; other site 935591003842 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 935591003843 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 935591003844 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 935591003845 dimer interface [polypeptide binding]; other site 935591003846 motif 1; other site 935591003847 active site 935591003848 motif 2; other site 935591003849 motif 3; other site 935591003850 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 935591003851 23S rRNA binding site [nucleotide binding]; other site 935591003852 L21 binding site [polypeptide binding]; other site 935591003853 L13 binding site [polypeptide binding]; other site 935591003854 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 935591003855 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 935591003856 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 935591003857 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 935591003858 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 935591003859 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 935591003860 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 935591003861 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 935591003862 active site 935591003863 dimer interface [polypeptide binding]; other site 935591003864 motif 1; other site 935591003865 motif 2; other site 935591003866 motif 3; other site 935591003867 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 935591003868 anticodon binding site; other site 935591003869 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 935591003870 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 935591003871 ferrochelatase; Reviewed; Region: hemH; PRK00035 935591003872 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 935591003873 C-terminal domain interface [polypeptide binding]; other site 935591003874 active site 935591003875 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 935591003876 active site 935591003877 N-terminal domain interface [polypeptide binding]; other site 935591003878 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 935591003879 Cytochrome c; Region: Cytochrom_C; pfam00034 935591003880 potassium/proton antiporter; Reviewed; Region: PRK05326 935591003881 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935591003882 Helix-turn-helix domain; Region: HTH_38; pfam13936 935591003883 Homeodomain-like domain; Region: HTH_32; pfam13565 935591003884 Integrase core domain; Region: rve; pfam00665 935591003885 Protein of unknown function (DUF808); Region: DUF808; cl01002 935591003886 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 935591003887 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 935591003888 putative active site [active] 935591003889 catalytic triad [active] 935591003890 putative dimer interface [polypeptide binding]; other site 935591003891 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 935591003892 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 935591003893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935591003894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935591003895 DNA binding residues [nucleotide binding] 935591003896 hypothetical protein; Provisional; Region: PRK11820 935591003897 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 935591003898 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 935591003899 Predicted membrane protein/domain [Function unknown]; Region: COG1714 935591003900 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 935591003901 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 935591003902 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 935591003903 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 935591003904 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 935591003905 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 935591003906 Sodium Bile acid symporter family; Region: SBF; pfam01758 935591003907 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 935591003908 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935591003909 RNA binding surface [nucleotide binding]; other site 935591003910 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 935591003911 active site 935591003912 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 935591003913 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 935591003914 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 935591003915 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 935591003916 Competence protein; Region: Competence; pfam03772 935591003917 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 935591003918 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 935591003919 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 935591003920 Autotransporter beta-domain; Region: Autotransporter; pfam03797 935591003921 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 935591003922 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 935591003923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591003924 catalytic residue [active] 935591003925 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 935591003926 putative active site [active] 935591003927 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 935591003928 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 935591003929 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 935591003930 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 935591003931 Walker A/P-loop; other site 935591003932 ATP binding site [chemical binding]; other site 935591003933 Q-loop/lid; other site 935591003934 ABC transporter signature motif; other site 935591003935 Walker B; other site 935591003936 D-loop; other site 935591003937 H-loop/switch region; other site 935591003938 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 935591003939 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935591003940 cell division protein FtsN; Region: ftsN; TIGR02223 935591003941 Sporulation related domain; Region: SPOR; pfam05036 935591003942 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 935591003943 Colicin V production protein; Region: Colicin_V; pfam02674 935591003944 amidophosphoribosyltransferase; Provisional; Region: PRK09246 935591003945 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 935591003946 active site 935591003947 tetramer interface [polypeptide binding]; other site 935591003948 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935591003949 active site 935591003950 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 935591003951 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 935591003952 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 935591003953 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 935591003954 active site 935591003955 GTPase Era; Reviewed; Region: era; PRK00089 935591003956 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 935591003957 G1 box; other site 935591003958 GTP/Mg2+ binding site [chemical binding]; other site 935591003959 Switch I region; other site 935591003960 G2 box; other site 935591003961 Switch II region; other site 935591003962 G3 box; other site 935591003963 G4 box; other site 935591003964 G5 box; other site 935591003965 KH domain; Region: KH_2; pfam07650 935591003966 ribonuclease III; Reviewed; Region: rnc; PRK00102 935591003967 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 935591003968 dimerization interface [polypeptide binding]; other site 935591003969 active site 935591003970 metal binding site [ion binding]; metal-binding site 935591003971 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 935591003972 dsRNA binding site [nucleotide binding]; other site 935591003973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4859 935591003974 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 935591003975 homopentamer interface [polypeptide binding]; other site 935591003976 active site 935591003977 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 935591003978 putative RNA binding site [nucleotide binding]; other site 935591003979 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 935591003980 active site 935591003981 substrate binding pocket [chemical binding]; other site 935591003982 dimer interface [polypeptide binding]; other site 935591003983 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 935591003984 CPxP motif; other site 935591003985 CNP1-like family; Region: CNP1; pfam08750 935591003986 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 935591003987 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 935591003988 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 935591003989 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 935591003990 substrate binding site [chemical binding]; other site 935591003991 active site 935591003992 catalytic residues [active] 935591003993 heterodimer interface [polypeptide binding]; other site 935591003994 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 935591003995 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 935591003996 Ligand binding site; other site 935591003997 oligomer interface; other site 935591003998 Uncharacterized conserved protein [Function unknown]; Region: COG2835 935591003999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 935591004000 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 935591004001 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 935591004002 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 935591004003 Malic enzyme, N-terminal domain; Region: malic; pfam00390 935591004004 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 935591004005 putative NAD(P) binding site [chemical binding]; other site 935591004006 thymidylate kinase; Validated; Region: tmk; PRK00698 935591004007 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 935591004008 TMP-binding site; other site 935591004009 ATP-binding site [chemical binding]; other site 935591004010 YceG-like family; Region: YceG; pfam02618 935591004011 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 935591004012 dimerization interface [polypeptide binding]; other site 935591004013 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 935591004014 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 935591004015 amidase catalytic site [active] 935591004016 Zn binding residues [ion binding]; other site 935591004017 substrate binding site [chemical binding]; other site 935591004018 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 935591004019 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 935591004020 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 935591004021 nucleotide binding pocket [chemical binding]; other site 935591004022 K-X-D-G motif; other site 935591004023 catalytic site [active] 935591004024 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 935591004025 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 935591004026 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 935591004027 Dimer interface [polypeptide binding]; other site 935591004028 BRCT sequence motif; other site 935591004029 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 935591004030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935591004031 FeS/SAM binding site; other site 935591004032 HemN C-terminal domain; Region: HemN_C; pfam06969 935591004033 Opacity family porin protein; Region: Opacity; pfam02462 935591004034 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 935591004035 homotrimer interaction site [polypeptide binding]; other site 935591004036 putative active site [active] 935591004037 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 935591004038 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 935591004039 active site 935591004040 metal binding site [ion binding]; metal-binding site 935591004041 Cation transport protein; Region: TrkH; cl17365 935591004042 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 935591004043 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935591004044 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 935591004045 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 935591004046 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935591004047 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 935591004048 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 935591004049 RNAase interaction site [polypeptide binding]; other site 935591004050 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935591004051 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 935591004052 nudix motif; other site 935591004053 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 935591004054 dimer interface [polypeptide binding]; other site 935591004055 substrate binding site [chemical binding]; other site 935591004056 metal binding sites [ion binding]; metal-binding site 935591004057 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 935591004058 active site 935591004059 dimerization interface [polypeptide binding]; other site 935591004060 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 935591004061 active site 935591004062 tetramer interface; other site 935591004063 argininosuccinate lyase; Provisional; Region: PRK00855 935591004064 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 935591004065 active sites [active] 935591004066 tetramer interface [polypeptide binding]; other site 935591004067 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 935591004068 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 935591004069 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 935591004070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935591004071 dimer interface [polypeptide binding]; other site 935591004072 conserved gate region; other site 935591004073 putative PBP binding loops; other site 935591004074 ABC-ATPase subunit interface; other site 935591004075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935591004076 dimer interface [polypeptide binding]; other site 935591004077 conserved gate region; other site 935591004078 ABC-ATPase subunit interface; other site 935591004079 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 935591004080 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 935591004081 Walker A/P-loop; other site 935591004082 ATP binding site [chemical binding]; other site 935591004083 Q-loop/lid; other site 935591004084 ABC transporter signature motif; other site 935591004085 Walker B; other site 935591004086 D-loop; other site 935591004087 H-loop/switch region; other site 935591004088 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 935591004089 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 935591004090 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 935591004091 putative active site [active] 935591004092 oxyanion strand; other site 935591004093 catalytic triad [active] 935591004094 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 935591004095 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 935591004096 catalytic residues [active] 935591004097 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 935591004098 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 935591004099 substrate binding site [chemical binding]; other site 935591004100 glutamase interaction surface [polypeptide binding]; other site 935591004101 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 935591004102 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 935591004103 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 935591004104 G1 box; other site 935591004105 putative GEF interaction site [polypeptide binding]; other site 935591004106 GTP/Mg2+ binding site [chemical binding]; other site 935591004107 Switch I region; other site 935591004108 G2 box; other site 935591004109 G3 box; other site 935591004110 Switch II region; other site 935591004111 G4 box; other site 935591004112 G5 box; other site 935591004113 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 935591004114 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 935591004115 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 935591004116 trimer interface [polypeptide binding]; other site 935591004117 putative metal binding site [ion binding]; other site 935591004118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 935591004119 active site 935591004120 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 935591004121 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 935591004122 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935591004123 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 935591004124 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 935591004125 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 935591004126 dinuclear metal binding motif [ion binding]; other site 935591004127 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 935591004128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935591004129 motif II; other site 935591004130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 935591004131 phosphoenolpyruvate synthase; Validated; Region: PRK06464 935591004132 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 935591004133 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 935591004134 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 935591004135 transcription termination factor Rho; Provisional; Region: rho; PRK09376 935591004136 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 935591004137 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 935591004138 RNA binding site [nucleotide binding]; other site 935591004139 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 935591004140 multimer interface [polypeptide binding]; other site 935591004141 Walker A motif; other site 935591004142 ATP binding site [chemical binding]; other site 935591004143 Walker B motif; other site 935591004144 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 935591004145 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 935591004146 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 935591004147 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 935591004148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935591004149 dimer interface [polypeptide binding]; other site 935591004150 conserved gate region; other site 935591004151 putative PBP binding loops; other site 935591004152 ABC-ATPase subunit interface; other site 935591004153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935591004154 dimer interface [polypeptide binding]; other site 935591004155 conserved gate region; other site 935591004156 putative PBP binding loops; other site 935591004157 ABC-ATPase subunit interface; other site 935591004158 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 935591004159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935591004160 Walker A/P-loop; other site 935591004161 ATP binding site [chemical binding]; other site 935591004162 Q-loop/lid; other site 935591004163 ABC transporter signature motif; other site 935591004164 Walker B; other site 935591004165 D-loop; other site 935591004166 H-loop/switch region; other site 935591004167 TOBE domain; Region: TOBE_2; pfam08402 935591004168 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 935591004169 16S/18S rRNA binding site [nucleotide binding]; other site 935591004170 S13e-L30e interaction site [polypeptide binding]; other site 935591004171 25S rRNA binding site [nucleotide binding]; other site 935591004172 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 935591004173 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 935591004174 Protein export membrane protein; Region: SecD_SecF; pfam02355 935591004175 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 935591004176 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 935591004177 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 935591004178 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 935591004179 Preprotein translocase subunit; Region: YajC; pfam02699 935591004180 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 935591004181 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 935591004182 putative active site [active] 935591004183 Zn binding site [ion binding]; other site 935591004184 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 935591004185 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 935591004186 putative NAD(P) binding site [chemical binding]; other site 935591004187 catalytic Zn binding site [ion binding]; other site 935591004188 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 935591004189 metal binding site [ion binding]; metal-binding site 935591004190 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 935591004191 nucleotide binding site/active site [active] 935591004192 HIT family signature motif; other site 935591004193 catalytic residue [active] 935591004194 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 935591004195 sec-independent translocase; Provisional; Region: PRK00708 935591004196 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 935591004197 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 935591004198 Maf-like protein; Region: Maf; pfam02545 935591004199 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 935591004200 active site 935591004201 dimer interface [polypeptide binding]; other site 935591004202 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 935591004203 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 935591004204 O-Antigen ligase; Region: Wzy_C; pfam04932 935591004205 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 935591004206 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 935591004207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935591004208 active site 935591004209 phosphorylation site [posttranslational modification] 935591004210 intermolecular recognition site; other site 935591004211 dimerization interface [polypeptide binding]; other site 935591004212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 935591004213 DNA binding site [nucleotide binding] 935591004214 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 935591004215 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935591004216 dimerization interface [polypeptide binding]; other site 935591004217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935591004218 dimer interface [polypeptide binding]; other site 935591004219 phosphorylation site [posttranslational modification] 935591004220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935591004221 ATP binding site [chemical binding]; other site 935591004222 Mg2+ binding site [ion binding]; other site 935591004223 G-X-G motif; other site 935591004224 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 935591004225 CoA binding domain; Region: CoA_binding_2; pfam13380 935591004226 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 935591004227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935591004228 Coenzyme A binding pocket [chemical binding]; other site 935591004229 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 935591004230 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 935591004231 RimM N-terminal domain; Region: RimM; pfam01782 935591004232 PRC-barrel domain; Region: PRC; pfam05239 935591004233 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 935591004234 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 935591004235 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 935591004236 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 935591004237 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 935591004238 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935591004239 ABC-ATPase subunit interface; other site 935591004240 dimer interface [polypeptide binding]; other site 935591004241 putative PBP binding regions; other site 935591004242 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 935591004243 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 935591004244 metal binding site [ion binding]; metal-binding site 935591004245 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 935591004246 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 935591004247 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 935591004248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935591004249 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 935591004250 putative active site [active] 935591004251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935591004252 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935591004253 Helix-turn-helix domain; Region: HTH_38; pfam13936 935591004254 Homeodomain-like domain; Region: HTH_32; pfam13565 935591004255 Integrase core domain; Region: rve; pfam00665 935591004256 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 935591004257 putative active site [active] 935591004258 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 935591004259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935591004260 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 935591004261 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 935591004262 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 935591004263 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 935591004264 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 935591004265 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 935591004266 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 935591004267 tRNA; other site 935591004268 putative tRNA binding site [nucleotide binding]; other site 935591004269 putative NADP binding site [chemical binding]; other site 935591004270 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 935591004271 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 935591004272 lipoyl attachment site [posttranslational modification]; other site 935591004273 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 935591004274 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 935591004275 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 935591004276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935591004277 putative DNA binding site [nucleotide binding]; other site 935591004278 putative Zn2+ binding site [ion binding]; other site 935591004279 AsnC family; Region: AsnC_trans_reg; pfam01037 935591004280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3310 935591004281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 935591004282 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 935591004283 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 935591004284 transmembrane helices; other site 935591004285 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 935591004286 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935591004287 E3 interaction surface; other site 935591004288 lipoyl attachment site [posttranslational modification]; other site 935591004289 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 935591004290 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 935591004291 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 935591004292 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 935591004293 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 935591004294 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 935591004295 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 935591004296 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935591004297 catalytic loop [active] 935591004298 iron binding site [ion binding]; other site 935591004299 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 935591004300 FAD binding pocket [chemical binding]; other site 935591004301 FAD binding motif [chemical binding]; other site 935591004302 phosphate binding motif [ion binding]; other site 935591004303 beta-alpha-beta structure motif; other site 935591004304 NAD binding pocket [chemical binding]; other site 935591004305 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 935591004306 ApbE family; Region: ApbE; pfam02424 935591004307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 935591004308 GrpE; Region: GrpE; pfam01025 935591004309 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 935591004310 dimer interface [polypeptide binding]; other site 935591004311 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 935591004312 serine acetyltransferase; Provisional; Region: cysE; PRK11132 935591004313 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 935591004314 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 935591004315 trimer interface [polypeptide binding]; other site 935591004316 active site 935591004317 substrate binding site [chemical binding]; other site 935591004318 CoA binding site [chemical binding]; other site 935591004319 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 935591004320 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 935591004321 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 935591004322 Predicted transcriptional regulator [Transcription]; Region: COG2932 935591004323 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935591004324 Catalytic site [active] 935591004325 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 935591004326 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 935591004327 nucleotide binding site [chemical binding]; other site 935591004328 Transposase domain (DUF772); Region: DUF772; pfam05598 935591004329 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591004330 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935591004331 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935591004332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935591004333 B-Box C-terminal domain; Region: BBC; smart00502 935591004334 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935591004335 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 935591004336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935591004337 ATP binding site [chemical binding]; other site 935591004338 putative Mg++ binding site [ion binding]; other site 935591004339 helicase superfamily c-terminal domain; Region: HELICc; smart00490 935591004340 ATP-binding site [chemical binding]; other site 935591004341 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 935591004342 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 935591004343 dimerization domain [polypeptide binding]; other site 935591004344 dimer interface [polypeptide binding]; other site 935591004345 catalytic residues [active] 935591004346 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 935591004347 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 935591004348 Walker A/P-loop; other site 935591004349 ATP binding site [chemical binding]; other site 935591004350 Q-loop/lid; other site 935591004351 ABC transporter signature motif; other site 935591004352 Walker B; other site 935591004353 D-loop; other site 935591004354 H-loop/switch region; other site 935591004355 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 935591004356 FtsX-like permease family; Region: FtsX; pfam02687 935591004357 macrolide transporter subunit MacA; Provisional; Region: PRK11578 935591004358 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935591004359 HlyD family secretion protein; Region: HlyD_3; pfam13437 935591004360 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 935591004361 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 935591004362 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 935591004363 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 935591004364 NAD binding site [chemical binding]; other site 935591004365 substrate binding site [chemical binding]; other site 935591004366 catalytic Zn binding site [ion binding]; other site 935591004367 tetramer interface [polypeptide binding]; other site 935591004368 structural Zn binding site [ion binding]; other site 935591004369 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 935591004370 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 935591004371 Walker A/P-loop; other site 935591004372 ATP binding site [chemical binding]; other site 935591004373 Q-loop/lid; other site 935591004374 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 935591004375 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 935591004376 ABC transporter signature motif; other site 935591004377 Walker B; other site 935591004378 D-loop; other site 935591004379 H-loop/switch region; other site 935591004380 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 935591004381 putative active site [active] 935591004382 putative metal binding site [ion binding]; other site 935591004383 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 935591004384 L-lactate permease; Region: Lactate_perm; cl00701 935591004385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 935591004386 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 935591004387 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 935591004388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935591004389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591004390 homodimer interface [polypeptide binding]; other site 935591004391 catalytic residue [active] 935591004392 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 935591004393 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 935591004394 domain interfaces; other site 935591004395 active site 935591004396 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 935591004397 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 935591004398 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 935591004399 Transporter associated domain; Region: CorC_HlyC; smart01091 935591004400 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 935591004401 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 935591004402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935591004403 putative substrate translocation pore; other site 935591004404 Predicted membrane protein [Function unknown]; Region: COG1238 935591004405 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 935591004406 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 935591004407 minor groove reading motif; other site 935591004408 helix-hairpin-helix signature motif; other site 935591004409 substrate binding pocket [chemical binding]; other site 935591004410 active site 935591004411 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 935591004412 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 935591004413 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 935591004414 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 935591004415 protein binding site [polypeptide binding]; other site 935591004416 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 935591004417 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 935591004418 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 935591004419 beta-hexosaminidase; Provisional; Region: PRK05337 935591004420 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 935591004421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935591004422 FeS/SAM binding site; other site 935591004423 Predicted membrane protein [Function unknown]; Region: COG3759 935591004424 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 935591004425 active site 935591004426 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 935591004427 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 935591004428 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 935591004429 Ligand Binding Site [chemical binding]; other site 935591004430 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 935591004431 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 935591004432 Integrase core domain; Region: rve; pfam00665 935591004433 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935591004434 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935591004435 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935591004436 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935591004437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 935591004438 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935591004439 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935591004440 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935591004441 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 935591004442 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 935591004443 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 935591004444 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 935591004445 Initiator Replication protein; Region: Rep_3; pfam01051 935591004446 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935591004447 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935591004448 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935591004449 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935591004450 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935591004451 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 935591004452 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 935591004453 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935591004454 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935591004455 Helix-turn-helix domain; Region: HTH_38; pfam13936 935591004456 Homeodomain-like domain; Region: HTH_32; pfam13565 935591004457 Integrase core domain; Region: rve; pfam00665 935591004458 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935591004459 Replication initiation factor; Region: Rep_trans; pfam02486 935591004460 Protein of unknown function (DUF1132); Region: DUF1132; pfam06575 935591004461 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935591004462 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 935591004463 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 935591004464 G1 box; other site 935591004465 GTP/Mg2+ binding site [chemical binding]; other site 935591004466 G2 box; other site 935591004467 Switch I region; other site 935591004468 G3 box; other site 935591004469 Switch II region; other site 935591004470 G4 box; other site 935591004471 G5 box; other site 935591004472 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 935591004473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935591004474 active site 935591004475 phosphorylation site [posttranslational modification] 935591004476 intermolecular recognition site; other site 935591004477 dimerization interface [polypeptide binding]; other site 935591004478 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 935591004479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591004480 S-adenosylmethionine binding site [chemical binding]; other site 935591004481 Protein of unknown function (DUF452); Region: DUF452; cl01062 935591004482 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 935591004483 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 935591004484 substrate-cofactor binding pocket; other site 935591004485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935591004486 catalytic residue [active] 935591004487 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 935591004488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 935591004489 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 935591004490 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 935591004491 transmembrane helices; other site 935591004492 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 935591004493 agmatinase; Region: agmatinase; TIGR01230 935591004494 oligomer interface [polypeptide binding]; other site 935591004495 putative active site [active] 935591004496 Mn binding site [ion binding]; other site 935591004497 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 935591004498 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 935591004499 dimer interface [polypeptide binding]; other site 935591004500 active site 935591004501 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935591004502 catalytic residues [active] 935591004503 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 935591004504 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 935591004505 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 935591004506 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 935591004507 dimer interface [polypeptide binding]; other site 935591004508 anticodon binding site; other site 935591004509 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 935591004510 homodimer interface [polypeptide binding]; other site 935591004511 motif 1; other site 935591004512 active site 935591004513 motif 2; other site 935591004514 GAD domain; Region: GAD; pfam02938 935591004515 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 935591004516 motif 3; other site 935591004517 Uncharacterized conserved protein [Function unknown]; Region: COG2928 935591004518 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 935591004519 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 935591004520 dimerization interface [polypeptide binding]; other site 935591004521 substrate binding site [chemical binding]; other site 935591004522 active site 935591004523 calcium binding site [ion binding]; other site 935591004524 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 935591004525 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 935591004526 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935591004527 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 935591004528 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935591004529 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935591004530 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935591004531 glutamate racemase; Provisional; Region: PRK00865 935591004532 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 935591004533 AMIN domain; Region: AMIN; pfam11741 935591004534 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 935591004535 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 935591004536 active site 935591004537 metal binding site [ion binding]; metal-binding site 935591004538 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 935591004539 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 935591004540 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 935591004541 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 935591004542 active site 935591004543 8-oxo-dGMP binding site [chemical binding]; other site 935591004544 nudix motif; other site 935591004545 metal binding site [ion binding]; metal-binding site 935591004546 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935591004547 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 935591004548 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 935591004549 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 935591004550 active site 935591004551 hydrophilic channel; other site 935591004552 dimerization interface [polypeptide binding]; other site 935591004553 catalytic residues [active] 935591004554 active site lid [active] 935591004555 Recombination protein O N terminal; Region: RecO_N; pfam11967 935591004556 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 935591004557 Recombination protein O C terminal; Region: RecO_C; pfam02565 935591004558 chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807 935591004559 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 935591004560 Prephenate dehydratase; Region: PDT; pfam00800 935591004561 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 935591004562 putative L-Phe binding site [chemical binding]; other site 935591004563 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 935591004564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935591004565 putative substrate translocation pore; other site 935591004566 EamA-like transporter family; Region: EamA; pfam00892 935591004567 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 935591004568 EamA-like transporter family; Region: EamA; pfam00892 935591004569 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935591004570 Predicted amidohydrolase [General function prediction only]; Region: COG0388 935591004571 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 935591004572 putative active site [active] 935591004573 catalytic triad [active] 935591004574 dimer interface [polypeptide binding]; other site 935591004575 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 935591004576 prephenate dehydrogenase; Validated; Region: PRK08507 935591004577 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 935591004578 Transcriptional regulator; Region: Rrf2; cl17282 935591004579 Rrf2 family protein; Region: rrf2_super; TIGR00738 935591004580 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 935591004581 propionate/acetate kinase; Provisional; Region: PRK12379 935591004582 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 935591004583 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 935591004584 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 935591004585 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 935591004586 substrate binding site [chemical binding]; other site 935591004587 ligand binding site [chemical binding]; other site 935591004588 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 935591004589 substrate binding site [chemical binding]; other site 935591004590 Protein of unknown function (DUF819); Region: DUF819; cl02317 935591004591 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 935591004592 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 935591004593 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 935591004594 dimer interface [polypeptide binding]; other site 935591004595 active site 935591004596 citrylCoA binding site [chemical binding]; other site 935591004597 oxalacetate/citrate binding site [chemical binding]; other site 935591004598 coenzyme A binding site [chemical binding]; other site 935591004599 catalytic triad [active] 935591004600 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 935591004601 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 935591004602 tetramer interface [polypeptide binding]; other site 935591004603 active site 935591004604 Mg2+/Mn2+ binding site [ion binding]; other site 935591004605 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 935591004606 cell division protein FtsZ; Validated; Region: PRK09330 935591004607 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 935591004608 nucleotide binding site [chemical binding]; other site 935591004609 SulA interaction site; other site 935591004610 cell division protein FtsA; Region: ftsA; TIGR01174 935591004611 Cell division protein FtsA; Region: FtsA; smart00842 935591004612 Cell division protein FtsA; Region: FtsA; pfam14450 935591004613 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 935591004614 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 935591004615 Cell division protein FtsQ; Region: FtsQ; pfam03799 935591004616 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 935591004617 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 935591004618 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935591004619 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 935591004620 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935591004621 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935591004622 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935591004623 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 935591004624 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 935591004625 active site 935591004626 homodimer interface [polypeptide binding]; other site 935591004627 cell division protein FtsW; Region: ftsW; TIGR02614 935591004628 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04308 935591004629 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935591004630 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935591004631 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935591004632 Sel1-like repeats; Region: SEL1; smart00671 935591004633 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 935591004634 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 935591004635 Mg++ binding site [ion binding]; other site 935591004636 putative catalytic motif [active] 935591004637 putative substrate binding site [chemical binding]; other site 935591004638 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 935591004639 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935591004640 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 935591004641 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935591004642 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935591004643 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 935591004644 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935591004645 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935591004646 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935591004647 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 935591004648 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 935591004649 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 935591004650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 935591004651 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 935591004652 MraW methylase family; Region: Methyltransf_5; cl17771 935591004653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 935591004654 MraZ protein; Region: MraZ; pfam02381 935591004655 MraZ protein; Region: MraZ; pfam02381 935591004656 Uncharacterized conserved protein [Function unknown]; Region: COG1565 935591004657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 935591004658 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 935591004659 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 935591004660 catalytic residues [active] 935591004661 hinge region; other site 935591004662 alpha helical domain; other site 935591004663 cell division protein FtsN; Region: ftsN; TIGR02223 935591004664 Sporulation related domain; Region: SPOR; pfam05036 935591004665 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 935591004666 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 935591004667 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 935591004668 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 935591004669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 935591004670 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 935591004671 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 935591004672 Na binding site [ion binding]; other site 935591004673 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 935591004674 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 935591004675 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 935591004676 Glutamate binding site [chemical binding]; other site 935591004677 NAD binding site [chemical binding]; other site 935591004678 catalytic residues [active] 935591004679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935591004680 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935591004681 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 935591004682 putative catalytic site [active] 935591004683 putative phosphate binding site [ion binding]; other site 935591004684 active site 935591004685 metal binding site A [ion binding]; metal-binding site 935591004686 DNA binding site [nucleotide binding] 935591004687 putative AP binding site [nucleotide binding]; other site 935591004688 putative metal binding site B [ion binding]; other site 935591004689 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935591004690 dimerization interface [polypeptide binding]; other site 935591004691 putative DNA binding site [nucleotide binding]; other site 935591004692 putative Zn2+ binding site [ion binding]; other site 935591004693 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 935591004694 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 935591004695 dimerization interface [polypeptide binding]; other site 935591004696 active site 935591004697 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 935591004698 quinolinate synthetase; Provisional; Region: PRK09375 935591004699 L-aspartate oxidase; Provisional; Region: PRK06175 935591004700 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 935591004701 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 935591004702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935591004703 motif II; other site 935591004704 maltose phosphorylase; Provisional; Region: PRK13807 935591004705 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 935591004706 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 935591004707 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 935591004708 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 935591004709 active site 935591004710 catalytic residues [active] 935591004711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935591004712 putative substrate translocation pore; other site 935591004713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935591004714 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 935591004715 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935591004716 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935591004717 ABC transporter; Region: ABC_tran_2; pfam12848 935591004718 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935591004719 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 935591004720 tetramer interfaces [polypeptide binding]; other site 935591004721 binuclear metal-binding site [ion binding]; other site 935591004722 thiamine-monophosphate kinase; Region: thiL; TIGR01379 935591004723 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 935591004724 ATP binding site [chemical binding]; other site 935591004725 dimerization interface [polypeptide binding]; other site 935591004726 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 935591004727 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 935591004728 ligand binding site [chemical binding]; other site 935591004729 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 935591004730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935591004731 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 935591004732 substrate binding site [chemical binding]; other site 935591004733 dimerization interface [polypeptide binding]; other site 935591004734 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 935591004735 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 935591004736 ligand binding site [chemical binding]; other site 935591004737 flexible hinge region; other site 935591004738 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 935591004739 putative switch regulator; other site 935591004740 non-specific DNA interactions [nucleotide binding]; other site 935591004741 DNA binding site [nucleotide binding] 935591004742 sequence specific DNA binding site [nucleotide binding]; other site 935591004743 putative cAMP binding site [chemical binding]; other site 935591004744 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 935591004745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935591004746 FeS/SAM binding site; other site 935591004747 HemN C-terminal domain; Region: HemN_C; pfam06969 935591004748 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 935591004749 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 935591004750 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 935591004751 Pretoxin HINT domain; Region: PT-HINT; pfam07591 935591004752 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 935591004753 thioester formation/cholesterol transfer; other site 935591004754 protein-splicing catalytic site; other site 935591004755 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 935591004756 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 935591004757 Pretoxin HINT domain; Region: PT-HINT; pfam07591 935591004758 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 935591004759 thioester formation/cholesterol transfer; other site 935591004760 protein-splicing catalytic site; other site 935591004761 RTX iron-regulated protein FrpC; Region: FrpC; pfam06901 935591004762 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 935591004763 GIY-YIG motif/motif A; other site 935591004764 putative active site [active] 935591004765 putative metal binding site [ion binding]; other site 935591004766 muropeptide transporter; Reviewed; Region: ampG; PRK11902 935591004767 AmpG-like permease; Region: 2A0125; TIGR00901 935591004768 glutamine synthetase; Provisional; Region: glnA; PRK09469 935591004769 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 935591004770 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 935591004771 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 935591004772 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 935591004773 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 935591004774 shikimate binding site; other site 935591004775 NAD(P) binding site [chemical binding]; other site 935591004776 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 935591004777 Transglycosylase; Region: Transgly; cl17702 935591004778 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 935591004779 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 935591004780 Walker A/P-loop; other site 935591004781 ATP binding site [chemical binding]; other site 935591004782 Q-loop/lid; other site 935591004783 ABC transporter signature motif; other site 935591004784 Walker B; other site 935591004785 D-loop; other site 935591004786 H-loop/switch region; other site 935591004787 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 935591004788 OstA-like protein; Region: OstA; pfam03968 935591004789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 935591004790 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 935591004791 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 935591004792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935591004793 active site 935591004794 motif I; other site 935591004795 motif II; other site 935591004796 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 935591004797 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 935591004798 putative active site [active] 935591004799 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 935591004800 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 935591004801 putative active site [active] 935591004802 transaldolase; Provisional; Region: PRK03903 935591004803 catalytic residue [active] 935591004804 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 935591004805 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 935591004806 active site 935591004807 HIGH motif; other site 935591004808 nucleotide binding site [chemical binding]; other site 935591004809 active site 935591004810 KMSKS motif; other site 935591004811 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 935591004812 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 935591004813 FMN binding site [chemical binding]; other site 935591004814 active site 935591004815 catalytic residues [active] 935591004816 substrate binding site [chemical binding]; other site 935591004817 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 935591004818 putative active site [active] 935591004819 dimerization interface [polypeptide binding]; other site 935591004820 putative tRNAtyr binding site [nucleotide binding]; other site 935591004821 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 935591004822 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 935591004823 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 935591004824 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 935591004825 YciI-like protein; Reviewed; Region: PRK11370 935591004826 intracellular septation protein A; Reviewed; Region: PRK00259 935591004827 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 935591004828 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935591004829 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 935591004830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935591004831 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 935591004832 dimer interface [polypeptide binding]; other site 935591004833 active site 935591004834 metal binding site [ion binding]; metal-binding site 935591004835 glutathione binding site [chemical binding]; other site 935591004836 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 935591004837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935591004838 TPR motif; other site 935591004839 binding surface 935591004840 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 935591004841 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 935591004842 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 935591004843 homodimer interface [polypeptide binding]; other site 935591004844 substrate-cofactor binding pocket; other site 935591004845 catalytic residue [active] 935591004846 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08690 935591004847 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 935591004848 NAD binding site [chemical binding]; other site 935591004849 homotetramer interface [polypeptide binding]; other site 935591004850 homodimer interface [polypeptide binding]; other site 935591004851 substrate binding site [chemical binding]; other site 935591004852 active site 935591004853 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 935591004854 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 935591004855 trimer interface [polypeptide binding]; other site 935591004856 active site 935591004857 substrate binding site [chemical binding]; other site 935591004858 CoA binding site [chemical binding]; other site 935591004859 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 935591004860 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 935591004861 active site 935591004862 dimer interface [polypeptide binding]; other site 935591004863 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 935591004864 dimer interface [polypeptide binding]; other site 935591004865 active site 935591004866 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 935591004867 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 935591004868 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 935591004869 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 935591004870 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 935591004871 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 935591004872 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 935591004873 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 935591004874 CoA-binding site [chemical binding]; other site 935591004875 ATP-binding [chemical binding]; other site 935591004876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3024 935591004877 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 935591004878 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 935591004879 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 935591004880 Walker A motif; other site 935591004881 ATP binding site [chemical binding]; other site 935591004882 Walker B motif; other site 935591004883 Predicted membrane protein [Function unknown]; Region: COG2707 935591004884 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 935591004885 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 935591004886 substrate binding pocket [chemical binding]; other site 935591004887 chain length determination region; other site 935591004888 substrate-Mg2+ binding site; other site 935591004889 catalytic residues [active] 935591004890 aspartate-rich region 1; other site 935591004891 active site lid residues [active] 935591004892 aspartate-rich region 2; other site 935591004893 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 935591004894 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 935591004895 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 935591004896 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 935591004897 hypothetical protein; Provisional; Region: PRK09126 935591004898 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 935591004899 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 935591004900 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 935591004901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935591004902 putative substrate translocation pore; other site 935591004903 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 935591004904 HlyD family secretion protein; Region: HlyD_3; pfam13437 935591004905 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 935591004906 hypothetical protein; Provisional; Region: PRK11212 935591004907 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 935591004908 Peptidase family M23; Region: Peptidase_M23; pfam01551 935591004909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 935591004910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 935591004911 binding surface 935591004912 Tetratricopeptide repeat; Region: TPR_16; pfam13432 935591004913 TPR motif; other site 935591004914 Protein of unknown function (DUF560); Region: DUF560; pfam04575 935591004915 Predicted membrane protein [Function unknown]; Region: COG1981 935591004916 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 935591004917 putative active site [active] 935591004918 putative metal binding residues [ion binding]; other site 935591004919 signature motif; other site 935591004920 putative dimer interface [polypeptide binding]; other site 935591004921 putative phosphate binding site [ion binding]; other site 935591004922 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 935591004923 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 935591004924 folate binding site [chemical binding]; other site 935591004925 NADP+ binding site [chemical binding]; other site 935591004926 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 935591004927 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 935591004928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935591004929 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 935591004930 Helix-hairpin-helix motif; Region: HHH; pfam00633 935591004931 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 935591004932 signal recognition particle protein; Provisional; Region: PRK10867 935591004933 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 935591004934 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 935591004935 P loop; other site 935591004936 GTP binding site [chemical binding]; other site 935591004937 Signal peptide binding domain; Region: SRP_SPB; pfam02978 935591004938 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935591004939 Helix-turn-helix domain; Region: HTH_38; pfam13936 935591004940 Homeodomain-like domain; Region: HTH_32; pfam13565 935591004941 Integrase core domain; Region: rve; pfam00665 935591004942 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 935591004943 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 935591004944 catalytic residues [active] 935591004945 hinge region; other site 935591004946 alpha helical domain; other site 935591004947 Uncharacterized conserved protein [Function unknown]; Region: COG1432 935591004948 LabA_like proteins; Region: LabA_like; cd06167 935591004949 putative metal binding site [ion binding]; other site 935591004950 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 935591004951 dimer interface [polypeptide binding]; other site 935591004952 FMN binding site [chemical binding]; other site 935591004953 Predicted membrane protein [Function unknown]; Region: COG2259 935591004954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935591004955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935591004956 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 935591004957 putative effector binding pocket; other site 935591004958 dimerization interface [polypeptide binding]; other site 935591004959 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 935591004960 DNA photolyase; Region: DNA_photolyase; pfam00875 935591004961 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 935591004962 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 935591004963 DEAD_2; Region: DEAD_2; pfam06733 935591004964 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 935591004965 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 935591004966 adenylosuccinate lyase; Provisional; Region: PRK09285 935591004967 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 935591004968 tetramer interface [polypeptide binding]; other site 935591004969 active site 935591004970 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 935591004971 Exoribonuclease R [Transcription]; Region: VacB; COG0557 935591004972 RNB domain; Region: RNB; pfam00773 935591004973 SurA N-terminal domain; Region: SurA_N; pfam09312 935591004974 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 935591004975 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 935591004976 Organic solvent tolerance protein; Region: OstA_C; pfam04453 935591004977 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 935591004978 Phosphotransferase enzyme family; Region: APH; pfam01636 935591004979 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 935591004980 catalytic residues [active] 935591004981 hinge region; other site 935591004982 alpha helical domain; other site 935591004983 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 935591004984 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 935591004985 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 935591004986 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 935591004987 active site 935591004988 ribulose/triose binding site [chemical binding]; other site 935591004989 phosphate binding site [ion binding]; other site 935591004990 substrate (anthranilate) binding pocket [chemical binding]; other site 935591004991 product (indole) binding pocket [chemical binding]; other site 935591004992 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 935591004993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935591004994 ATP binding site [chemical binding]; other site 935591004995 putative Mg++ binding site [ion binding]; other site 935591004996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935591004997 nucleotide binding region [chemical binding]; other site 935591004998 ATP-binding site [chemical binding]; other site 935591004999 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 935591005000 Helicase and RNase D C-terminal; Region: HRDC; smart00341 935591005001 Helicase and RNase D C-terminal; Region: HRDC; smart00341 935591005002 Helicase and RNase D C-terminal; Region: HRDC; smart00341 935591005003 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 935591005004 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 935591005005 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 935591005006 TAP-like protein; Region: Abhydrolase_4; pfam08386 935591005007 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 935591005008 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935591005009 active site 935591005010 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 935591005011 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 935591005012 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 935591005013 Predicted membrane protein [Function unknown]; Region: COG3212 935591005014 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 935591005015 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 935591005016 RuvA N terminal domain; Region: RuvA_N; pfam01330 935591005017 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 935591005018 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 935591005019 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935591005020 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 935591005021 Walker A/P-loop; other site 935591005022 ATP binding site [chemical binding]; other site 935591005023 Q-loop/lid; other site 935591005024 ABC transporter signature motif; other site 935591005025 Walker B; other site 935591005026 D-loop; other site 935591005027 H-loop/switch region; other site 935591005028 GTPase RsgA; Reviewed; Region: PRK00098 935591005029 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 935591005030 RNA binding site [nucleotide binding]; other site 935591005031 homodimer interface [polypeptide binding]; other site 935591005032 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 935591005033 GTPase/Zn-binding domain interface [polypeptide binding]; other site 935591005034 GTP/Mg2+ binding site [chemical binding]; other site 935591005035 G4 box; other site 935591005036 G5 box; other site 935591005037 G1 box; other site 935591005038 Switch I region; other site 935591005039 G2 box; other site 935591005040 G3 box; other site 935591005041 Switch II region; other site 935591005042 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 935591005043 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 935591005044 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 935591005045 substrate binding pocket [chemical binding]; other site 935591005046 chain length determination region; other site 935591005047 substrate-Mg2+ binding site; other site 935591005048 catalytic residues [active] 935591005049 aspartate-rich region 1; other site 935591005050 active site lid residues [active] 935591005051 aspartate-rich region 2; other site 935591005052 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 935591005053 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 935591005054 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935591005055 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 935591005056 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935591005057 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 935591005058 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 935591005059 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935591005060 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 935591005061 Fic/DOC family; Region: Fic; pfam02661 935591005062 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 935591005063 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 935591005064 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 935591005065 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 935591005066 4Fe-4S binding domain; Region: Fer4; cl02805 935591005067 4Fe-4S binding domain; Region: Fer4; pfam00037 935591005068 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 935591005069 NADH dehydrogenase subunit G; Validated; Region: PRK09129 935591005070 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935591005071 catalytic loop [active] 935591005072 iron binding site [ion binding]; other site 935591005073 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 935591005074 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 935591005075 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 935591005076 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 935591005077 SLBB domain; Region: SLBB; pfam10531 935591005078 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 935591005079 NADH dehydrogenase subunit E; Validated; Region: PRK07539 935591005080 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 935591005081 putative dimer interface [polypeptide binding]; other site 935591005082 [2Fe-2S] cluster binding site [ion binding]; other site 935591005083 NADH dehydrogenase subunit D; Validated; Region: PRK06075 935591005084 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 935591005085 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 935591005086 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 935591005087 NADH dehydrogenase subunit B; Validated; Region: PRK06411 935591005088 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 935591005089 spermidine synthase; Provisional; Region: PRK03612 935591005090 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 935591005091 DNA helicase II; Region: uvrD; TIGR01075 935591005092 Part of AAA domain; Region: AAA_19; pfam13245 935591005093 Family description; Region: UvrD_C_2; pfam13538 935591005094 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 935591005095 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 935591005096 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 935591005097 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 935591005098 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 935591005099 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 935591005100 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935591005101 Helix-turn-helix domain; Region: HTH_38; pfam13936 935591005102 Homeodomain-like domain; Region: HTH_32; pfam13565 935591005103 Integrase core domain; Region: rve; pfam00665 935591005104 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 935591005105 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935591005106 metal binding triad; other site 935591005107 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 935591005108 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935591005109 metal binding triad; other site 935591005110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4304 935591005111 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 935591005112 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 935591005113 quinone interaction residues [chemical binding]; other site 935591005114 active site 935591005115 catalytic residues [active] 935591005116 FMN binding site [chemical binding]; other site 935591005117 substrate binding site [chemical binding]; other site 935591005118 acyl carrier protein; Provisional; Region: acpP; PRK00982 935591005119 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 935591005120 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 935591005121 dimer interface [polypeptide binding]; other site 935591005122 active site 935591005123 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935591005124 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 935591005125 putative ADP-binding pocket [chemical binding]; other site 935591005126 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 935591005127 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 935591005128 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 935591005129 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 935591005130 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 935591005131 tetramer interface [polypeptide binding]; other site 935591005132 heme binding pocket [chemical binding]; other site 935591005133 NADPH binding site [chemical binding]; other site 935591005134 Predicted membrane protein [Function unknown]; Region: COG1971 935591005135 Domain of unknown function DUF; Region: DUF204; pfam02659 935591005136 Domain of unknown function DUF; Region: DUF204; pfam02659 935591005137 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 935591005138 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 935591005139 active site 935591005140 Zn binding site [ion binding]; other site 935591005141 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 935591005142 Mechanosensitive ion channel; Region: MS_channel; pfam00924 935591005143 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 935591005144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935591005145 Mg2+ binding site [ion binding]; other site 935591005146 G-X-G motif; other site 935591005147 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 935591005148 anchoring element; other site 935591005149 dimer interface [polypeptide binding]; other site 935591005150 ATP binding site [chemical binding]; other site 935591005151 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 935591005152 active site 935591005153 putative metal-binding site [ion binding]; other site 935591005154 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 935591005155 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 935591005156 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 935591005157 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 935591005158 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 935591005159 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 935591005160 putative cation:proton antiport protein; Provisional; Region: PRK10669 935591005161 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 935591005162 TrkA-N domain; Region: TrkA_N; pfam02254 935591005163 TrkA-C domain; Region: TrkA_C; pfam02080 935591005164 ferredoxin; Provisional; Region: PRK08764 935591005165 Putative Fe-S cluster; Region: FeS; cl17515 935591005166 4Fe-4S binding domain; Region: Fer4; pfam00037 935591005167 4Fe-4S binding domain; Region: Fer4; pfam00037 935591005168 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 935591005169 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 935591005170 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 935591005171 Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360 935591005172 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 935591005173 metal binding site 2 [ion binding]; metal-binding site 935591005174 putative DNA binding helix; other site 935591005175 metal binding site 1 [ion binding]; metal-binding site 935591005176 dimer interface [polypeptide binding]; other site 935591005177 structural Zn2+ binding site [ion binding]; other site 935591005178 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 935591005179 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 935591005180 dihydrodipicolinate reductase; Provisional; Region: PRK00048 935591005181 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 935591005182 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 935591005183 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 935591005184 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 935591005185 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 935591005186 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935591005187 RNA binding surface [nucleotide binding]; other site 935591005188 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 935591005189 active site 935591005190 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 935591005191 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 935591005192 homodimer interface [polypeptide binding]; other site 935591005193 oligonucleotide binding site [chemical binding]; other site 935591005194 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 935591005195 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 935591005196 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935591005197 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 935591005198 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 935591005199 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 935591005200 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 935591005201 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 935591005202 RNA/DNA hybrid binding site [nucleotide binding]; other site 935591005203 active site 935591005204 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 935591005205 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 935591005206 P-loop; other site 935591005207 Magnesium ion binding site [ion binding]; other site 935591005208 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 935591005209 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 935591005210 Magnesium ion binding site [ion binding]; other site 935591005211 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 935591005212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591005213 S-adenosylmethionine binding site [chemical binding]; other site 935591005214 Predicted membrane protein [Function unknown]; Region: COG1289 935591005215 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 935591005216 ribosome recycling factor; Reviewed; Region: frr; PRK00083 935591005217 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 935591005218 hinge region; other site 935591005219 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 935591005220 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 935591005221 catalytic residue [active] 935591005222 putative FPP diphosphate binding site; other site 935591005223 putative FPP binding hydrophobic cleft; other site 935591005224 dimer interface [polypeptide binding]; other site 935591005225 putative IPP diphosphate binding site; other site 935591005226 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 935591005227 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 935591005228 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 935591005229 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 935591005230 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 935591005231 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 935591005232 zinc metallopeptidase RseP; Provisional; Region: PRK10779 935591005233 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 935591005234 active site 935591005235 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 935591005236 protein binding site [polypeptide binding]; other site 935591005237 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 935591005238 protein binding site [polypeptide binding]; other site 935591005239 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 935591005240 putative substrate binding region [chemical binding]; other site 935591005241 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 935591005242 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935591005243 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935591005244 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935591005245 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935591005246 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935591005247 Surface antigen; Region: Bac_surface_Ag; pfam01103 935591005248 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 935591005249 periplasmic chaperone; Provisional; Region: PRK10780 935591005250 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 935591005251 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 935591005252 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 935591005253 trimer interface [polypeptide binding]; other site 935591005254 active site 935591005255 UDP-GlcNAc binding site [chemical binding]; other site 935591005256 lipid binding site [chemical binding]; lipid-binding site 935591005257 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 935591005258 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 935591005259 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 935591005260 active site 935591005261 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935591005262 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 935591005263 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 935591005264 hydroxyglutarate oxidase; Provisional; Region: PRK11728 935591005265 zinc transporter ZupT; Provisional; Region: PRK04201 935591005266 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 935591005267 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 935591005268 HIGH motif; other site 935591005269 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 935591005270 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 935591005271 active site 935591005272 KMSKS motif; other site 935591005273 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 935591005274 tRNA binding surface [nucleotide binding]; other site 935591005275 anticodon binding site; other site 935591005276 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 935591005277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935591005278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935591005279 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 935591005280 dimerization interface [polypeptide binding]; other site 935591005281 cell division topological specificity factor MinE; Provisional; Region: PRK13989 935591005282 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 935591005283 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 935591005284 Switch I; other site 935591005285 Switch II; other site 935591005286 septum formation inhibitor; Reviewed; Region: minC; PRK04516 935591005287 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 935591005288 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 935591005289 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 935591005290 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 935591005291 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 935591005292 alphaNTD homodimer interface [polypeptide binding]; other site 935591005293 alphaNTD - beta interaction site [polypeptide binding]; other site 935591005294 alphaNTD - beta' interaction site [polypeptide binding]; other site 935591005295 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 935591005296 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 935591005297 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 935591005298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935591005299 RNA binding surface [nucleotide binding]; other site 935591005300 30S ribosomal protein S11; Validated; Region: PRK05309 935591005301 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 935591005302 30S ribosomal protein S13; Region: bact_S13; TIGR03631 935591005303 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 935591005304 rRNA binding site [nucleotide binding]; other site 935591005305 predicted 30S ribosome binding site; other site 935591005306 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 935591005307 SecY translocase; Region: SecY; pfam00344 935591005308 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 935591005309 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 935591005310 23S rRNA binding site [nucleotide binding]; other site 935591005311 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 935591005312 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 935591005313 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 935591005314 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 935591005315 5S rRNA interface [nucleotide binding]; other site 935591005316 23S rRNA interface [nucleotide binding]; other site 935591005317 L5 interface [polypeptide binding]; other site 935591005318 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 935591005319 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 935591005320 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 935591005321 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 935591005322 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 935591005323 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 935591005324 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 935591005325 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 935591005326 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 935591005327 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 935591005328 RNA binding site [nucleotide binding]; other site 935591005329 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 935591005330 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 935591005331 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 935591005332 23S rRNA interface [nucleotide binding]; other site 935591005333 putative translocon interaction site; other site 935591005334 signal recognition particle (SRP54) interaction site; other site 935591005335 L23 interface [polypeptide binding]; other site 935591005336 trigger factor interaction site; other site 935591005337 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 935591005338 23S rRNA interface [nucleotide binding]; other site 935591005339 5S rRNA interface [nucleotide binding]; other site 935591005340 putative antibiotic binding site [chemical binding]; other site 935591005341 L25 interface [polypeptide binding]; other site 935591005342 L27 interface [polypeptide binding]; other site 935591005343 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 935591005344 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 935591005345 G-X-X-G motif; other site 935591005346 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 935591005347 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 935591005348 putative translocon binding site; other site 935591005349 protein-rRNA interface [nucleotide binding]; other site 935591005350 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 935591005351 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 935591005352 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 935591005353 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 935591005354 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 935591005355 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 935591005356 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 935591005357 Transposase domain (DUF772); Region: DUF772; pfam05598 935591005358 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591005359 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 935591005360 elongation factor Tu; Reviewed; Region: PRK00049 935591005361 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 935591005362 G1 box; other site 935591005363 GEF interaction site [polypeptide binding]; other site 935591005364 GTP/Mg2+ binding site [chemical binding]; other site 935591005365 Switch I region; other site 935591005366 G2 box; other site 935591005367 G3 box; other site 935591005368 Switch II region; other site 935591005369 G4 box; other site 935591005370 G5 box; other site 935591005371 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 935591005372 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 935591005373 Antibiotic Binding Site [chemical binding]; other site 935591005374 elongation factor G; Reviewed; Region: PRK00007 935591005375 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 935591005376 G1 box; other site 935591005377 putative GEF interaction site [polypeptide binding]; other site 935591005378 GTP/Mg2+ binding site [chemical binding]; other site 935591005379 Switch I region; other site 935591005380 G2 box; other site 935591005381 G3 box; other site 935591005382 Switch II region; other site 935591005383 G4 box; other site 935591005384 G5 box; other site 935591005385 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 935591005386 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 935591005387 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 935591005388 30S ribosomal protein S7; Validated; Region: PRK05302 935591005389 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 935591005390 S17 interaction site [polypeptide binding]; other site 935591005391 S8 interaction site; other site 935591005392 16S rRNA interaction site [nucleotide binding]; other site 935591005393 streptomycin interaction site [chemical binding]; other site 935591005394 23S rRNA interaction site [nucleotide binding]; other site 935591005395 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 935591005396 Protein of unknown function (DUF560); Region: DUF560; pfam04575 935591005397 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 935591005398 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 935591005399 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 935591005400 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 935591005401 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 935591005402 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 935591005403 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 935591005404 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 935591005405 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 935591005406 DNA binding site [nucleotide binding] 935591005407 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 935591005408 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 935591005409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 935591005410 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 935591005411 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 935591005412 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 935591005413 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 935591005414 RPB3 interaction site [polypeptide binding]; other site 935591005415 RPB1 interaction site [polypeptide binding]; other site 935591005416 RPB11 interaction site [polypeptide binding]; other site 935591005417 RPB10 interaction site [polypeptide binding]; other site 935591005418 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 935591005419 core dimer interface [polypeptide binding]; other site 935591005420 peripheral dimer interface [polypeptide binding]; other site 935591005421 L10 interface [polypeptide binding]; other site 935591005422 L11 interface [polypeptide binding]; other site 935591005423 putative EF-Tu interaction site [polypeptide binding]; other site 935591005424 putative EF-G interaction site [polypeptide binding]; other site 935591005425 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 935591005426 23S rRNA interface [nucleotide binding]; other site 935591005427 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 935591005428 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 935591005429 mRNA/rRNA interface [nucleotide binding]; other site 935591005430 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 935591005431 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 935591005432 23S rRNA interface [nucleotide binding]; other site 935591005433 L7/L12 interface [polypeptide binding]; other site 935591005434 putative thiostrepton binding site; other site 935591005435 L25 interface [polypeptide binding]; other site 935591005436 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 935591005437 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 935591005438 putative homodimer interface [polypeptide binding]; other site 935591005439 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 935591005440 heterodimer interface [polypeptide binding]; other site 935591005441 homodimer interface [polypeptide binding]; other site 935591005442 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 935591005443 elongation factor Tu; Reviewed; Region: PRK00049 935591005444 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 935591005445 G1 box; other site 935591005446 GEF interaction site [polypeptide binding]; other site 935591005447 GTP/Mg2+ binding site [chemical binding]; other site 935591005448 Switch I region; other site 935591005449 G2 box; other site 935591005450 G3 box; other site 935591005451 Switch II region; other site 935591005452 G4 box; other site 935591005453 G5 box; other site 935591005454 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 935591005455 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 935591005456 Antibiotic Binding Site [chemical binding]; other site 935591005457 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 935591005458 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 935591005459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591005460 S-adenosylmethionine binding site [chemical binding]; other site 935591005461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 935591005462 sequence-specific DNA binding site [nucleotide binding]; other site 935591005463 salt bridge; other site 935591005464 DNA topoisomerase I; Validated; Region: PRK06599 935591005465 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 935591005466 active site 935591005467 interdomain interaction site; other site 935591005468 putative metal-binding site [ion binding]; other site 935591005469 nucleotide binding site [chemical binding]; other site 935591005470 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 935591005471 domain I; other site 935591005472 DNA binding groove [nucleotide binding] 935591005473 phosphate binding site [ion binding]; other site 935591005474 domain II; other site 935591005475 domain III; other site 935591005476 nucleotide binding site [chemical binding]; other site 935591005477 catalytic site [active] 935591005478 domain IV; other site 935591005479 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 935591005480 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 935591005481 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 935591005482 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 935591005483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Smg; COG2922 935591005484 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 935591005485 DNA protecting protein DprA; Region: dprA; TIGR00732 935591005486 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 935591005487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935591005488 active site 935591005489 phosphorylation site [posttranslational modification] 935591005490 intermolecular recognition site; other site 935591005491 dimerization interface [polypeptide binding]; other site 935591005492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 935591005493 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 935591005494 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 935591005495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935591005496 dimerization interface [polypeptide binding]; other site 935591005497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935591005498 dimer interface [polypeptide binding]; other site 935591005499 phosphorylation site [posttranslational modification] 935591005500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935591005501 ATP binding site [chemical binding]; other site 935591005502 Mg2+ binding site [ion binding]; other site 935591005503 G-X-G motif; other site 935591005504 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 935591005505 16S rRNA methyltransferase B; Provisional; Region: PRK10901 935591005506 NusB family; Region: NusB; pfam01029 935591005507 putative RNA binding site [nucleotide binding]; other site 935591005508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935591005509 S-adenosylmethionine binding site [chemical binding]; other site 935591005510 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 935591005511 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 935591005512 putative active site [active] 935591005513 substrate binding site [chemical binding]; other site 935591005514 putative cosubstrate binding site; other site 935591005515 catalytic site [active] 935591005516 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 935591005517 substrate binding site [chemical binding]; other site 935591005518 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 935591005519 active site 935591005520 catalytic residues [active] 935591005521 metal binding site [ion binding]; metal-binding site 935591005522 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935591005523 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 935591005524 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 935591005525 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 935591005526 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 935591005527 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 935591005528 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 935591005529 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 935591005530 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 935591005531 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 935591005532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935591005533 Coenzyme A binding pocket [chemical binding]; other site 935591005534 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 935591005535 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 935591005536 Predicted methyltransferases [General function prediction only]; Region: COG0313 935591005537 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 935591005538 putative SAM binding site [chemical binding]; other site 935591005539 putative homodimer interface [polypeptide binding]; other site 935591005540 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 935591005541 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 935591005542 dimer interface [polypeptide binding]; other site 935591005543 active site 935591005544 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 935591005545 BON domain; Region: BON; pfam04972 935591005546 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 935591005547 active site 935591005548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935591005549 non-specific DNA binding site [nucleotide binding]; other site 935591005550 salt bridge; other site 935591005551 sequence-specific DNA binding site [nucleotide binding]; other site 935591005552 malate:quinone oxidoreductase; Validated; Region: PRK05257 935591005553 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 935591005554 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 935591005555 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 935591005556 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 935591005557 rRNA interaction site [nucleotide binding]; other site 935591005558 S8 interaction site; other site 935591005559 putative laminin-1 binding site; other site 935591005560 elongation factor Ts; Provisional; Region: tsf; PRK09377 935591005561 UBA/TS-N domain; Region: UBA; pfam00627 935591005562 Elongation factor TS; Region: EF_TS; pfam00889 935591005563 Elongation factor TS; Region: EF_TS; pfam00889 935591005564 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 935591005565 putative nucleotide binding site [chemical binding]; other site 935591005566 uridine monophosphate binding site [chemical binding]; other site 935591005567 homohexameric interface [polypeptide binding]; other site 935591005568 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935591005569 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935591005570 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 935591005571 Pyocin large subunit [General function prediction only]; Region: COG5529 935591005572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935591005573 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 935591005574 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 935591005575 tandem repeat interface [polypeptide binding]; other site 935591005576 oligomer interface [polypeptide binding]; other site 935591005577 active site residues [active] 935591005578 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 935591005579 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 935591005580 putative MPT binding site; other site 935591005581 argininosuccinate synthase; Validated; Region: PRK05370 935591005582 argininosuccinate synthase; Provisional; Region: PRK13820 935591005583 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935591005584 serine/threonine transporter SstT; Provisional; Region: PRK13628 935591005585 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 935591005586 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 935591005587 Surface antigen; Region: Bac_surface_Ag; pfam01103 935591005588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 935591005589 Family of unknown function (DUF490); Region: DUF490; pfam04357 935591005590 Family of unknown function (DUF490); Region: DUF490; pfam04357 935591005591 Family of unknown function (DUF490); Region: DUF490; pfam04357 935591005592 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 935591005593 POT family; Region: PTR2; cl17359 935591005594 peptide chain release factor 2; Validated; Region: prfB; PRK00578 935591005595 This domain is found in peptide chain release factors; Region: PCRF; smart00937 935591005596 RF-1 domain; Region: RF-1; pfam00472 935591005597 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 935591005598 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 935591005599 active site 935591005600 nucleophile elbow; other site 935591005601 Predicted membrane protein [Function unknown]; Region: COG2259 935591005602 Protein of unknown function (DUF692); Region: DUF692; pfam05114 935591005603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 935591005604 RNA polymerase sigma factor; Provisional; Region: PRK12532 935591005605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935591005606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935591005607 DNA binding residues [nucleotide binding] 935591005608 Transposase domain (DUF772); Region: DUF772; pfam05598 935591005609 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935591005610 DDE superfamily endonuclease; Region: DDE_4; cl17710 935591005611 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 935591005612 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 935591005613 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 935591005614 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 935591005615 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 935591005616 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 935591005617 Uncharacterized conserved protein [Function unknown]; Region: COG1739 935591005618 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 935591005619 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 935591005620 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 935591005621 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 935591005622 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 935591005623 Ligand binding site [chemical binding]; other site 935591005624 Electron transfer flavoprotein domain; Region: ETF; pfam01012 935591005625 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 935591005626 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 935591005627 putative active site [active] 935591005628 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 935591005629 Isochorismatase family; Region: Isochorismatase; pfam00857 935591005630 catalytic triad [active] 935591005631 metal binding site [ion binding]; metal-binding site 935591005632 conserved cis-peptide bond; other site 935591005633 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 935591005634 homodimer interaction site [polypeptide binding]; other site 935591005635 cofactor binding site; other site 935591005636 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 935591005637 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 935591005638 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 935591005639 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 935591005640 MutS domain I; Region: MutS_I; pfam01624 935591005641 MutS domain II; Region: MutS_II; pfam05188 935591005642 MutS domain III; Region: MutS_III; pfam05192 935591005643 MutS domain V; Region: MutS_V; pfam00488 935591005644 Walker A/P-loop; other site 935591005645 ATP binding site [chemical binding]; other site 935591005646 Q-loop/lid; other site 935591005647 ABC transporter signature motif; other site 935591005648 Walker B; other site 935591005649 D-loop; other site 935591005650 H-loop/switch region; other site