-- dump date 20140619_163614 -- class Genbank::misc_feature -- table misc_feature_note -- id note 935593000001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 935593000002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935593000003 Coenzyme A binding pocket [chemical binding]; other site 935593000004 Myosin tail; Region: Myosin_tail_1; pfam01576 935593000005 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 935593000006 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 935593000007 active site 935593000008 HIGH motif; other site 935593000009 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 935593000010 active site 935593000011 KMSKS motif; other site 935593000012 Uncharacterized conserved protein [Function unknown]; Region: COG1434 935593000013 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 935593000014 putative active site [active] 935593000015 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 935593000016 ArsC family; Region: ArsC; pfam03960 935593000017 catalytic residues [active] 935593000018 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935593000019 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935593000020 catalytic residues [active] 935593000021 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 935593000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935593000023 Walker A/P-loop; other site 935593000024 ATP binding site [chemical binding]; other site 935593000025 Q-loop/lid; other site 935593000026 ABC transporter signature motif; other site 935593000027 Walker B; other site 935593000028 D-loop; other site 935593000029 H-loop/switch region; other site 935593000030 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 935593000031 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 935593000032 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 935593000033 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 935593000034 Phosphoglycerate kinase; Region: PGK; pfam00162 935593000035 substrate binding site [chemical binding]; other site 935593000036 hinge regions; other site 935593000037 ADP binding site [chemical binding]; other site 935593000038 catalytic site [active] 935593000039 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 935593000040 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 935593000041 hinge; other site 935593000042 active site 935593000043 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 935593000044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 935593000045 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 935593000046 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 935593000047 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 935593000048 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 935593000049 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 935593000050 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 935593000051 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 935593000052 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 935593000053 Pilin (bacterial filament); Region: Pilin; pfam00114 935593000054 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935593000055 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935593000056 Pilin (bacterial filament); Region: Pilin; pfam00114 935593000057 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935593000058 Pilin (bacterial filament); Region: Pilin; pfam00114 935593000059 Transposase domain (DUF772); Region: DUF772; pfam05598 935593000060 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593000061 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593000062 Pilin (bacterial filament); Region: Pilin; pfam00114 935593000063 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935593000064 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 935593000065 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935593000066 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 935593000067 glycerate dehydrogenase; Provisional; Region: PRK06487 935593000068 putative ligand binding site [chemical binding]; other site 935593000069 putative NAD binding site [chemical binding]; other site 935593000070 catalytic site [active] 935593000071 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 935593000072 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 935593000073 active site 935593000074 HIGH motif; other site 935593000075 KMSKS motif; other site 935593000076 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 935593000077 tRNA binding surface [nucleotide binding]; other site 935593000078 anticodon binding site; other site 935593000079 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 935593000080 dimer interface [polypeptide binding]; other site 935593000081 putative tRNA-binding site [nucleotide binding]; other site 935593000082 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 935593000083 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 935593000084 glutaminase active site [active] 935593000085 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 935593000086 dimer interface [polypeptide binding]; other site 935593000087 active site 935593000088 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 935593000089 dimer interface [polypeptide binding]; other site 935593000090 active site 935593000091 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 935593000092 MltA specific insert domain; Region: MltA; pfam03562 935593000093 3D domain; Region: 3D; pfam06725 935593000094 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 935593000095 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 935593000096 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 935593000097 Imelysin; Region: Peptidase_M75; pfam09375 935593000098 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 935593000099 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 935593000100 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 935593000101 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 935593000102 PhnA protein; Region: PhnA; pfam03831 935593000103 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 935593000104 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 935593000105 Substrate binding site; other site 935593000106 Mg++ binding site; other site 935593000107 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 935593000108 active site 935593000109 substrate binding site [chemical binding]; other site 935593000110 CoA binding site [chemical binding]; other site 935593000111 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 935593000112 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935593000113 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 935593000114 Conserved TM helix; Region: TM_helix; pfam05552 935593000115 Mechanosensitive ion channel; Region: MS_channel; pfam00924 935593000116 Competence-damaged protein; Region: CinA; pfam02464 935593000117 trifunctional thioredoxin/methionine sulfoxide reductase A/B protein; Provisional; Region: PRK14018 935593000118 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935593000119 catalytic residues [active] 935593000120 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 935593000121 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 935593000122 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 935593000123 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 935593000124 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 935593000125 P loop; other site 935593000126 GTP binding site [chemical binding]; other site 935593000127 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 935593000128 GIY-YIG motif/motif A; other site 935593000129 putative active site [active] 935593000130 putative metal binding site [ion binding]; other site 935593000131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935593000132 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935593000133 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935593000134 Zonular occludens toxin (Zot); Region: Zot; cl17485 935593000135 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 935593000136 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935593000137 Protein of unknown function (DUF1132); Region: DUF1132; pfam06575 935593000138 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935593000139 Replication initiation factor; Region: Rep_trans; pfam02486 935593000140 TIGR01666 family membrane protein; Region: YCCS 935593000141 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 935593000142 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 935593000143 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 935593000144 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 935593000145 Walker A motif; other site 935593000146 ATP binding site [chemical binding]; other site 935593000147 Walker B motif; other site 935593000148 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 935593000149 SPOC domain; Region: SPOC; pfam07744 935593000150 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 935593000151 Walker A motif; other site 935593000152 ATP binding site [chemical binding]; other site 935593000153 Walker B motif; other site 935593000154 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 935593000155 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935593000156 catalytic residue [active] 935593000157 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 935593000158 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 935593000159 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 935593000160 comEA protein; Region: comE; TIGR01259 935593000161 Helix-hairpin-helix motif; Region: HHH; pfam00633 935593000162 chaperone protein DnaJ; Provisional; Region: PRK10767 935593000163 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935593000164 HSP70 interaction site [polypeptide binding]; other site 935593000165 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 935593000166 substrate binding site [polypeptide binding]; other site 935593000167 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 935593000168 Zn binding sites [ion binding]; other site 935593000169 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 935593000170 dimer interface [polypeptide binding]; other site 935593000171 Predicted membrane protein [Function unknown]; Region: COG1297 935593000172 putative oligopeptide transporter, OPT family; Region: TIGR00733 935593000173 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 935593000174 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 935593000175 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 935593000176 substrate binding site; other site 935593000177 tetramer interface; other site 935593000178 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 935593000179 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 935593000180 NAD binding site [chemical binding]; other site 935593000181 substrate binding site [chemical binding]; other site 935593000182 homodimer interface [polypeptide binding]; other site 935593000183 active site 935593000184 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 935593000185 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 935593000186 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 935593000187 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 935593000188 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 935593000189 RNA binding site [nucleotide binding]; other site 935593000190 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 935593000191 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 935593000192 Walker A/P-loop; other site 935593000193 ATP binding site [chemical binding]; other site 935593000194 Q-loop/lid; other site 935593000195 ABC transporter signature motif; other site 935593000196 Walker B; other site 935593000197 D-loop; other site 935593000198 H-loop/switch region; other site 935593000199 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 935593000200 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 935593000201 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 935593000202 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 935593000203 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 935593000204 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 935593000205 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593000206 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 935593000207 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 935593000208 active site 935593000209 homodimer interface [polypeptide binding]; other site 935593000210 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 935593000211 ligand binding site; other site 935593000212 tetramer interface; other site 935593000213 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 935593000214 NeuB family; Region: NeuB; pfam03102 935593000215 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 935593000216 NeuB binding interface [polypeptide binding]; other site 935593000217 putative substrate binding site [chemical binding]; other site 935593000218 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 935593000219 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 935593000220 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 935593000221 NAD binding site [chemical binding]; other site 935593000222 homodimer interface [polypeptide binding]; other site 935593000223 active site 935593000224 substrate binding site [chemical binding]; other site 935593000225 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 935593000226 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 935593000227 NAD binding site [chemical binding]; other site 935593000228 substrate binding site [chemical binding]; other site 935593000229 homodimer interface [polypeptide binding]; other site 935593000230 active site 935593000231 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 935593000232 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 935593000233 substrate binding site; other site 935593000234 tetramer interface; other site 935593000235 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593000236 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593000237 Homeodomain-like domain; Region: HTH_32; pfam13565 935593000238 Integrase core domain; Region: rve; pfam00665 935593000239 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 935593000240 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593000241 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 935593000242 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 935593000243 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 935593000244 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 935593000245 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935593000246 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935593000247 Sel1-like repeats; Region: SEL1; smart00671 935593000248 Sel1-like repeats; Region: SEL1; smart00671 935593000249 Sel1-like repeats; Region: SEL1; smart00671 935593000250 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 935593000251 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 935593000252 cyanate hydratase; Validated; Region: PRK02866 935593000253 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 935593000254 pyruvate kinase; Provisional; Region: PRK05826 935593000255 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 935593000256 domain interfaces; other site 935593000257 active site 935593000258 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 935593000259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935593000260 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 935593000261 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 935593000262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935593000263 Coenzyme A binding pocket [chemical binding]; other site 935593000264 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 935593000265 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 935593000266 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 935593000267 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 935593000268 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 935593000269 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 935593000270 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935593000271 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 935593000272 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 935593000273 active site 935593000274 catalytic residues [active] 935593000275 metal binding site [ion binding]; metal-binding site 935593000276 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 935593000277 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 935593000278 putative active site [active] 935593000279 substrate binding site [chemical binding]; other site 935593000280 putative cosubstrate binding site; other site 935593000281 catalytic site [active] 935593000282 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 935593000283 substrate binding site [chemical binding]; other site 935593000284 16S rRNA methyltransferase B; Provisional; Region: PRK10901 935593000285 NusB family; Region: NusB; pfam01029 935593000286 putative RNA binding site [nucleotide binding]; other site 935593000287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593000288 S-adenosylmethionine binding site [chemical binding]; other site 935593000289 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 935593000290 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 935593000291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935593000292 dimerization interface [polypeptide binding]; other site 935593000293 PAS domain; Region: PAS; smart00091 935593000294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935593000295 dimer interface [polypeptide binding]; other site 935593000296 phosphorylation site [posttranslational modification] 935593000297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935593000298 ATP binding site [chemical binding]; other site 935593000299 Mg2+ binding site [ion binding]; other site 935593000300 G-X-G motif; other site 935593000301 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 935593000302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935593000303 active site 935593000304 phosphorylation site [posttranslational modification] 935593000305 intermolecular recognition site; other site 935593000306 dimerization interface [polypeptide binding]; other site 935593000307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 935593000308 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 935593000309 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 935593000310 DNA protecting protein DprA; Region: dprA; TIGR00732 935593000311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Smg; COG2922 935593000312 DNA topoisomerase I; Validated; Region: PRK06599 935593000313 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 935593000314 active site 935593000315 interdomain interaction site; other site 935593000316 putative metal-binding site [ion binding]; other site 935593000317 nucleotide binding site [chemical binding]; other site 935593000318 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 935593000319 domain I; other site 935593000320 DNA binding groove [nucleotide binding] 935593000321 phosphate binding site [ion binding]; other site 935593000322 domain II; other site 935593000323 domain III; other site 935593000324 nucleotide binding site [chemical binding]; other site 935593000325 catalytic site [active] 935593000326 domain IV; other site 935593000327 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 935593000328 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 935593000329 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 935593000330 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 935593000331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 935593000332 sequence-specific DNA binding site [nucleotide binding]; other site 935593000333 salt bridge; other site 935593000334 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 935593000335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593000336 S-adenosylmethionine binding site [chemical binding]; other site 935593000337 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 935593000338 elongation factor Tu; Reviewed; Region: PRK00049 935593000339 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 935593000340 G1 box; other site 935593000341 GEF interaction site [polypeptide binding]; other site 935593000342 GTP/Mg2+ binding site [chemical binding]; other site 935593000343 Switch I region; other site 935593000344 G2 box; other site 935593000345 G3 box; other site 935593000346 Switch II region; other site 935593000347 G4 box; other site 935593000348 G5 box; other site 935593000349 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 935593000350 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 935593000351 Antibiotic Binding Site [chemical binding]; other site 935593000352 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 935593000353 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 935593000354 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 935593000355 putative homodimer interface [polypeptide binding]; other site 935593000356 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 935593000357 heterodimer interface [polypeptide binding]; other site 935593000358 homodimer interface [polypeptide binding]; other site 935593000359 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 935593000360 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 935593000361 23S rRNA interface [nucleotide binding]; other site 935593000362 L7/L12 interface [polypeptide binding]; other site 935593000363 putative thiostrepton binding site; other site 935593000364 L25 interface [polypeptide binding]; other site 935593000365 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 935593000366 mRNA/rRNA interface [nucleotide binding]; other site 935593000367 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 935593000368 23S rRNA interface [nucleotide binding]; other site 935593000369 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 935593000370 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 935593000371 core dimer interface [polypeptide binding]; other site 935593000372 peripheral dimer interface [polypeptide binding]; other site 935593000373 L10 interface [polypeptide binding]; other site 935593000374 L11 interface [polypeptide binding]; other site 935593000375 putative EF-Tu interaction site [polypeptide binding]; other site 935593000376 putative EF-G interaction site [polypeptide binding]; other site 935593000377 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 935593000378 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 935593000379 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 935593000380 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 935593000381 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 935593000382 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 935593000383 RPB3 interaction site [polypeptide binding]; other site 935593000384 RPB1 interaction site [polypeptide binding]; other site 935593000385 RPB11 interaction site [polypeptide binding]; other site 935593000386 RPB10 interaction site [polypeptide binding]; other site 935593000387 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 935593000388 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 935593000389 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 935593000390 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 935593000391 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 935593000392 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 935593000393 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 935593000394 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 935593000395 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 935593000396 DNA binding site [nucleotide binding] 935593000397 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 935593000398 Protein of unknown function (DUF560); Region: DUF560; pfam04575 935593000399 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 935593000400 S17 interaction site [polypeptide binding]; other site 935593000401 S8 interaction site; other site 935593000402 16S rRNA interaction site [nucleotide binding]; other site 935593000403 streptomycin interaction site [chemical binding]; other site 935593000404 23S rRNA interaction site [nucleotide binding]; other site 935593000405 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 935593000406 30S ribosomal protein S7; Validated; Region: PRK05302 935593000407 elongation factor G; Reviewed; Region: PRK00007 935593000408 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 935593000409 G1 box; other site 935593000410 putative GEF interaction site [polypeptide binding]; other site 935593000411 GTP/Mg2+ binding site [chemical binding]; other site 935593000412 Switch I region; other site 935593000413 G2 box; other site 935593000414 G3 box; other site 935593000415 Switch II region; other site 935593000416 G4 box; other site 935593000417 G5 box; other site 935593000418 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 935593000419 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 935593000420 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 935593000421 elongation factor Tu; Reviewed; Region: PRK00049 935593000422 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 935593000423 G1 box; other site 935593000424 GEF interaction site [polypeptide binding]; other site 935593000425 GTP/Mg2+ binding site [chemical binding]; other site 935593000426 Switch I region; other site 935593000427 G2 box; other site 935593000428 G3 box; other site 935593000429 Switch II region; other site 935593000430 G4 box; other site 935593000431 G5 box; other site 935593000432 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 935593000433 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 935593000434 Antibiotic Binding Site [chemical binding]; other site 935593000435 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 935593000436 Transposase domain (DUF772); Region: DUF772; pfam05598 935593000437 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593000438 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 935593000439 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 935593000440 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 935593000441 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 935593000442 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 935593000443 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 935593000444 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 935593000445 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 935593000446 putative translocon binding site; other site 935593000447 protein-rRNA interface [nucleotide binding]; other site 935593000448 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 935593000449 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 935593000450 G-X-X-G motif; other site 935593000451 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 935593000452 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 935593000453 23S rRNA interface [nucleotide binding]; other site 935593000454 5S rRNA interface [nucleotide binding]; other site 935593000455 putative antibiotic binding site [chemical binding]; other site 935593000456 L25 interface [polypeptide binding]; other site 935593000457 L27 interface [polypeptide binding]; other site 935593000458 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 935593000459 23S rRNA interface [nucleotide binding]; other site 935593000460 putative translocon interaction site; other site 935593000461 signal recognition particle (SRP54) interaction site; other site 935593000462 L23 interface [polypeptide binding]; other site 935593000463 trigger factor interaction site; other site 935593000464 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 935593000465 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 935593000466 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 935593000467 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 935593000468 RNA binding site [nucleotide binding]; other site 935593000469 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 935593000470 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 935593000471 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 935593000472 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 935593000473 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 935593000474 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 935593000475 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 935593000476 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 935593000477 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 935593000478 5S rRNA interface [nucleotide binding]; other site 935593000479 23S rRNA interface [nucleotide binding]; other site 935593000480 L5 interface [polypeptide binding]; other site 935593000481 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 935593000482 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 935593000483 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 935593000484 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 935593000485 23S rRNA binding site [nucleotide binding]; other site 935593000486 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 935593000487 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 935593000488 SecY translocase; Region: SecY; pfam00344 935593000489 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 935593000490 rRNA binding site [nucleotide binding]; other site 935593000491 predicted 30S ribosome binding site; other site 935593000492 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 935593000493 30S ribosomal protein S13; Region: bact_S13; TIGR03631 935593000494 30S ribosomal protein S11; Validated; Region: PRK05309 935593000495 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 935593000496 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 935593000497 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935593000498 RNA binding surface [nucleotide binding]; other site 935593000499 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 935593000500 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 935593000501 alphaNTD homodimer interface [polypeptide binding]; other site 935593000502 alphaNTD - beta interaction site [polypeptide binding]; other site 935593000503 alphaNTD - beta' interaction site [polypeptide binding]; other site 935593000504 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 935593000505 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 935593000506 septum formation inhibitor; Reviewed; Region: minC; PRK04516 935593000507 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 935593000508 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 935593000509 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 935593000510 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 935593000511 Switch I; other site 935593000512 Switch II; other site 935593000513 cell division topological specificity factor MinE; Provisional; Region: PRK13989 935593000514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935593000515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935593000516 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 935593000517 dimerization interface [polypeptide binding]; other site 935593000518 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 935593000519 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 935593000520 HIGH motif; other site 935593000521 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 935593000522 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 935593000523 active site 935593000524 KMSKS motif; other site 935593000525 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 935593000526 tRNA binding surface [nucleotide binding]; other site 935593000527 anticodon binding site; other site 935593000528 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 935593000529 zinc transporter ZupT; Provisional; Region: PRK04201 935593000530 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 935593000531 hydroxyglutarate oxidase; Provisional; Region: PRK11728 935593000532 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935593000533 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 935593000534 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 935593000535 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 935593000536 active site 935593000537 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 935593000538 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 935593000539 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 935593000540 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 935593000541 trimer interface [polypeptide binding]; other site 935593000542 active site 935593000543 UDP-GlcNAc binding site [chemical binding]; other site 935593000544 lipid binding site [chemical binding]; lipid-binding site 935593000545 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 935593000546 periplasmic chaperone; Provisional; Region: PRK10780 935593000547 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 935593000548 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935593000549 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935593000550 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935593000551 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935593000552 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935593000553 Surface antigen; Region: Bac_surface_Ag; pfam01103 935593000554 zinc metallopeptidase RseP; Provisional; Region: PRK10779 935593000555 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 935593000556 active site 935593000557 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 935593000558 protein binding site [polypeptide binding]; other site 935593000559 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 935593000560 protein binding site [polypeptide binding]; other site 935593000561 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 935593000562 putative substrate binding region [chemical binding]; other site 935593000563 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 935593000564 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 935593000565 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 935593000566 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 935593000567 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 935593000568 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 935593000569 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 935593000570 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 935593000571 catalytic residue [active] 935593000572 putative FPP diphosphate binding site; other site 935593000573 putative FPP binding hydrophobic cleft; other site 935593000574 dimer interface [polypeptide binding]; other site 935593000575 putative IPP diphosphate binding site; other site 935593000576 ribosome recycling factor; Reviewed; Region: frr; PRK00083 935593000577 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 935593000578 hinge region; other site 935593000579 Predicted membrane protein [Function unknown]; Region: COG1289 935593000580 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 935593000581 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 935593000582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593000583 S-adenosylmethionine binding site [chemical binding]; other site 935593000584 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 935593000585 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 935593000586 P-loop; other site 935593000587 Magnesium ion binding site [ion binding]; other site 935593000588 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 935593000589 DTAP/Switch II; other site 935593000590 Switch I; other site 935593000591 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 935593000592 Magnesium ion binding site [ion binding]; other site 935593000593 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 935593000594 RNA/DNA hybrid binding site [nucleotide binding]; other site 935593000595 active site 935593000596 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 935593000597 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 935593000598 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 935593000599 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935593000600 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 935593000601 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 935593000602 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 935593000603 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 935593000604 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 935593000605 homodimer interface [polypeptide binding]; other site 935593000606 oligonucleotide binding site [chemical binding]; other site 935593000607 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 935593000608 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935593000609 RNA binding surface [nucleotide binding]; other site 935593000610 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 935593000611 active site 935593000612 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 935593000613 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 935593000614 dihydrodipicolinate reductase; Provisional; Region: PRK00048 935593000615 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 935593000616 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 935593000617 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 935593000618 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 935593000619 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 935593000620 metal binding site 2 [ion binding]; metal-binding site 935593000621 putative DNA binding helix; other site 935593000622 metal binding site 1 [ion binding]; metal-binding site 935593000623 dimer interface [polypeptide binding]; other site 935593000624 structural Zn2+ binding site [ion binding]; other site 935593000625 Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360 935593000626 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 935593000627 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 935593000628 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 935593000629 ferredoxin; Provisional; Region: PRK08764 935593000630 Putative Fe-S cluster; Region: FeS; cl17515 935593000631 4Fe-4S binding domain; Region: Fer4; pfam00037 935593000632 4Fe-4S binding domain; Region: Fer4; pfam00037 935593000633 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 935593000634 putative cation:proton antiport protein; Provisional; Region: PRK10669 935593000635 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 935593000636 TrkA-N domain; Region: TrkA_N; pfam02254 935593000637 TrkA-C domain; Region: TrkA_C; pfam02080 935593000638 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 935593000639 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 935593000640 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 935593000641 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 935593000642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935593000643 Mg2+ binding site [ion binding]; other site 935593000644 G-X-G motif; other site 935593000645 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 935593000646 anchoring element; other site 935593000647 dimer interface [polypeptide binding]; other site 935593000648 ATP binding site [chemical binding]; other site 935593000649 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 935593000650 active site 935593000651 putative metal-binding site [ion binding]; other site 935593000652 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 935593000653 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 935593000654 Mechanosensitive ion channel; Region: MS_channel; pfam00924 935593000655 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 935593000656 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 935593000657 active site 935593000658 Zn binding site [ion binding]; other site 935593000659 Predicted membrane protein [Function unknown]; Region: COG1971 935593000660 Domain of unknown function DUF; Region: DUF204; pfam02659 935593000661 Domain of unknown function DUF; Region: DUF204; pfam02659 935593000662 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 935593000663 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 935593000664 tetramer interface [polypeptide binding]; other site 935593000665 heme binding pocket [chemical binding]; other site 935593000666 NADPH binding site [chemical binding]; other site 935593000667 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 935593000668 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 935593000669 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 935593000670 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 935593000671 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 935593000672 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 935593000673 dimer interface [polypeptide binding]; other site 935593000674 active site 935593000675 acyl carrier protein; Provisional; Region: acpP; PRK00982 935593000676 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 935593000677 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 935593000678 quinone interaction residues [chemical binding]; other site 935593000679 active site 935593000680 catalytic residues [active] 935593000681 FMN binding site [chemical binding]; other site 935593000682 substrate binding site [chemical binding]; other site 935593000683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4304 935593000684 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 935593000685 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935593000686 metal binding triad; other site 935593000687 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 935593000688 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935593000689 metal binding triad; other site 935593000690 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593000691 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593000692 Homeodomain-like domain; Region: HTH_32; pfam13565 935593000693 Integrase core domain; Region: rve; pfam00665 935593000694 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 935593000695 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 935593000696 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 935593000697 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 935593000698 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 935593000699 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 935593000700 DNA helicase II; Region: uvrD; TIGR01075 935593000701 Part of AAA domain; Region: AAA_19; pfam13245 935593000702 Family description; Region: UvrD_C_2; pfam13538 935593000703 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 935593000704 spermidine synthase; Provisional; Region: PRK03612 935593000705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935593000706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593000707 S-adenosylmethionine binding site [chemical binding]; other site 935593000708 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 935593000709 NADH dehydrogenase subunit B; Validated; Region: PRK06411 935593000710 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 935593000711 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 935593000712 NADH dehydrogenase subunit D; Validated; Region: PRK06075 935593000713 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 935593000714 NADH dehydrogenase subunit E; Validated; Region: PRK07539 935593000715 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 935593000716 putative dimer interface [polypeptide binding]; other site 935593000717 [2Fe-2S] cluster binding site [ion binding]; other site 935593000718 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 935593000719 SLBB domain; Region: SLBB; pfam10531 935593000720 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 935593000721 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 935593000722 putative active site [active] 935593000723 GIY-YIG motif/motif A; other site 935593000724 putative metal binding site [ion binding]; other site 935593000725 NADH dehydrogenase subunit G; Validated; Region: PRK09129 935593000726 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935593000727 catalytic loop [active] 935593000728 iron binding site [ion binding]; other site 935593000729 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 935593000730 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 935593000731 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 935593000732 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 935593000733 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 935593000734 4Fe-4S binding domain; Region: Fer4; cl02805 935593000735 4Fe-4S binding domain; Region: Fer4; pfam00037 935593000736 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 935593000737 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 935593000738 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 935593000739 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 935593000740 Fic/DOC family; Region: Fic; pfam02661 935593000741 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 935593000742 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 935593000743 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935593000744 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 935593000745 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935593000746 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 935593000747 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935593000748 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 935593000749 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 935593000750 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 935593000751 substrate binding pocket [chemical binding]; other site 935593000752 chain length determination region; other site 935593000753 substrate-Mg2+ binding site; other site 935593000754 catalytic residues [active] 935593000755 aspartate-rich region 1; other site 935593000756 active site lid residues [active] 935593000757 aspartate-rich region 2; other site 935593000758 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 935593000759 GTPase RsgA; Reviewed; Region: PRK00098 935593000760 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 935593000761 RNA binding site [nucleotide binding]; other site 935593000762 homodimer interface [polypeptide binding]; other site 935593000763 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 935593000764 GTPase/Zn-binding domain interface [polypeptide binding]; other site 935593000765 GTP/Mg2+ binding site [chemical binding]; other site 935593000766 G4 box; other site 935593000767 G5 box; other site 935593000768 G1 box; other site 935593000769 Switch I region; other site 935593000770 G2 box; other site 935593000771 G3 box; other site 935593000772 Switch II region; other site 935593000773 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 935593000774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935593000775 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 935593000776 Walker A/P-loop; other site 935593000777 ATP binding site [chemical binding]; other site 935593000778 Q-loop/lid; other site 935593000779 ABC transporter signature motif; other site 935593000780 Walker B; other site 935593000781 D-loop; other site 935593000782 H-loop/switch region; other site 935593000783 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 935593000784 RuvA N terminal domain; Region: RuvA_N; pfam01330 935593000785 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 935593000786 Predicted membrane protein [Function unknown]; Region: COG3212 935593000787 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 935593000788 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 935593000789 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 935593000790 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 935593000791 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 935593000792 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935593000793 active site 935593000794 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 935593000795 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 935593000796 TAP-like protein; Region: Abhydrolase_4; pfam08386 935593000797 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 935593000798 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 935593000799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935593000800 ATP binding site [chemical binding]; other site 935593000801 putative Mg++ binding site [ion binding]; other site 935593000802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935593000803 nucleotide binding region [chemical binding]; other site 935593000804 ATP-binding site [chemical binding]; other site 935593000805 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 935593000806 HRDC domain; Region: HRDC; pfam00570 935593000807 Helicase and RNase D C-terminal; Region: HRDC; smart00341 935593000808 Helicase and RNase D C-terminal; Region: HRDC; smart00341 935593000809 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 935593000810 active site 935593000811 ribulose/triose binding site [chemical binding]; other site 935593000812 phosphate binding site [ion binding]; other site 935593000813 substrate (anthranilate) binding pocket [chemical binding]; other site 935593000814 product (indole) binding pocket [chemical binding]; other site 935593000815 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 935593000816 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 935593000817 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 935593000818 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 935593000819 catalytic residues [active] 935593000820 hinge region; other site 935593000821 alpha helical domain; other site 935593000822 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 935593000823 Phosphotransferase enzyme family; Region: APH; pfam01636 935593000824 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 935593000825 Organic solvent tolerance protein; Region: OstA_C; pfam04453 935593000826 SurA N-terminal domain; Region: SurA_N; pfam09312 935593000827 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 935593000828 Exoribonuclease R [Transcription]; Region: VacB; COG0557 935593000829 RNB domain; Region: RNB; pfam00773 935593000830 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 935593000831 adenylosuccinate lyase; Provisional; Region: PRK09285 935593000832 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 935593000833 tetramer interface [polypeptide binding]; other site 935593000834 active site 935593000835 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 935593000836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 935593000837 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 935593000838 putative metal binding site [ion binding]; other site 935593000839 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 935593000840 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 935593000841 DEAD_2; Region: DEAD_2; pfam06733 935593000842 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 935593000843 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 935593000844 DNA photolyase; Region: DNA_photolyase; pfam00875 935593000845 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935593000846 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935593000847 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 935593000848 putative effector binding pocket; other site 935593000849 dimerization interface [polypeptide binding]; other site 935593000850 Predicted membrane protein [Function unknown]; Region: COG2259 935593000851 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 935593000852 dimer interface [polypeptide binding]; other site 935593000853 FMN binding site [chemical binding]; other site 935593000854 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 935593000855 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 935593000856 catalytic residues [active] 935593000857 hinge region; other site 935593000858 alpha helical domain; other site 935593000859 signal recognition particle protein; Provisional; Region: PRK10867 935593000860 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 935593000861 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 935593000862 P loop; other site 935593000863 GTP binding site [chemical binding]; other site 935593000864 Signal peptide binding domain; Region: SRP_SPB; pfam02978 935593000865 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 935593000866 comEA protein; Region: comE; TIGR01259 935593000867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935593000868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 935593000869 DDE superfamily endonuclease; Region: DDE_3; pfam13358 935593000870 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 935593000871 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 935593000872 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 935593000873 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 935593000874 folate binding site [chemical binding]; other site 935593000875 NADP+ binding site [chemical binding]; other site 935593000876 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 935593000877 putative active site [active] 935593000878 putative metal binding residues [ion binding]; other site 935593000879 signature motif; other site 935593000880 putative dimer interface [polypeptide binding]; other site 935593000881 putative phosphate binding site [ion binding]; other site 935593000882 Predicted membrane protein [Function unknown]; Region: COG1981 935593000883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935593000884 TPR motif; other site 935593000885 Tetratricopeptide repeat; Region: TPR_16; pfam13432 935593000886 binding surface 935593000887 Protein of unknown function (DUF560); Region: DUF560; pfam04575 935593000888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 935593000889 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 935593000890 Peptidase family M23; Region: Peptidase_M23; pfam01551 935593000891 hypothetical protein; Provisional; Region: PRK11212 935593000892 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 935593000893 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 935593000894 HlyD family secretion protein; Region: HlyD_3; pfam13437 935593000895 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 935593000896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935593000897 putative substrate translocation pore; other site 935593000898 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 935593000899 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 935593000900 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 935593000901 hypothetical protein; Provisional; Region: PRK09126 935593000902 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 935593000903 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 935593000904 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 935593000905 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 935593000906 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 935593000907 substrate binding pocket [chemical binding]; other site 935593000908 chain length determination region; other site 935593000909 substrate-Mg2+ binding site; other site 935593000910 catalytic residues [active] 935593000911 aspartate-rich region 1; other site 935593000912 active site lid residues [active] 935593000913 aspartate-rich region 2; other site 935593000914 Predicted membrane protein [Function unknown]; Region: COG2707 935593000915 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 935593000916 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 935593000917 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 935593000918 Walker A motif; other site 935593000919 ATP binding site [chemical binding]; other site 935593000920 Walker B motif; other site 935593000921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3024 935593000922 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 935593000923 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 935593000924 CoA-binding site [chemical binding]; other site 935593000925 ATP-binding [chemical binding]; other site 935593000926 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 935593000927 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 935593000928 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 935593000929 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 935593000930 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 935593000931 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 935593000932 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 935593000933 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 935593000934 active site 935593000935 dimer interface [polypeptide binding]; other site 935593000936 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 935593000937 dimer interface [polypeptide binding]; other site 935593000938 active site 935593000939 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 935593000940 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 935593000941 trimer interface [polypeptide binding]; other site 935593000942 active site 935593000943 substrate binding site [chemical binding]; other site 935593000944 CoA binding site [chemical binding]; other site 935593000945 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08690 935593000946 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 935593000947 NAD binding site [chemical binding]; other site 935593000948 homotetramer interface [polypeptide binding]; other site 935593000949 homodimer interface [polypeptide binding]; other site 935593000950 substrate binding site [chemical binding]; other site 935593000951 active site 935593000952 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 935593000953 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 935593000954 homodimer interface [polypeptide binding]; other site 935593000955 substrate-cofactor binding pocket; other site 935593000956 catalytic residue [active] 935593000957 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 935593000958 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 935593000959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 935593000960 TPR motif; other site 935593000961 binding surface 935593000962 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935593000963 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 935593000964 dimer interface [polypeptide binding]; other site 935593000965 active site 935593000966 metal binding site [ion binding]; metal-binding site 935593000967 glutathione binding site [chemical binding]; other site 935593000968 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 935593000969 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935593000970 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 935593000971 intracellular septation protein A; Reviewed; Region: PRK00259 935593000972 YciI-like protein; Reviewed; Region: PRK11370 935593000973 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 935593000974 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 935593000975 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 935593000976 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 935593000977 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 935593000978 putative active site [active] 935593000979 dimerization interface [polypeptide binding]; other site 935593000980 putative tRNAtyr binding site [nucleotide binding]; other site 935593000981 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 935593000982 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 935593000983 FMN binding site [chemical binding]; other site 935593000984 active site 935593000985 catalytic residues [active] 935593000986 substrate binding site [chemical binding]; other site 935593000987 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 935593000988 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 935593000989 active site 935593000990 HIGH motif; other site 935593000991 nucleotide binding site [chemical binding]; other site 935593000992 active site 935593000993 KMSKS motif; other site 935593000994 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 935593000995 putative active site [active] 935593000996 transaldolase; Provisional; Region: PRK03903 935593000997 catalytic residue [active] 935593000998 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 935593000999 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 935593001000 putative active site [active] 935593001001 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 935593001002 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 935593001003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935593001004 active site 935593001005 motif I; other site 935593001006 motif II; other site 935593001007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 935593001008 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 935593001009 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 935593001010 OstA-like protein; Region: OstA; pfam03968 935593001011 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 935593001012 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 935593001013 Walker A/P-loop; other site 935593001014 ATP binding site [chemical binding]; other site 935593001015 Q-loop/lid; other site 935593001016 ABC transporter signature motif; other site 935593001017 Walker B; other site 935593001018 D-loop; other site 935593001019 H-loop/switch region; other site 935593001020 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 935593001021 Transglycosylase; Region: Transgly; cl17702 935593001022 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 935593001023 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 935593001024 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 935593001025 shikimate binding site; other site 935593001026 NAD(P) binding site [chemical binding]; other site 935593001027 glutamine synthetase; Provisional; Region: glnA; PRK09469 935593001028 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 935593001029 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 935593001030 muropeptide transporter; Reviewed; Region: ampG; PRK11902 935593001031 AmpG-like permease; Region: 2A0125; TIGR00901 935593001032 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 935593001033 GIY-YIG motif/motif A; other site 935593001034 putative active site [active] 935593001035 putative metal binding site [ion binding]; other site 935593001036 RTX iron-regulated protein FrpC; Region: FrpC; pfam06901 935593001037 Pretoxin HINT domain; Region: PT-HINT; pfam07591 935593001038 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 935593001039 thioester formation/cholesterol transfer; other site 935593001040 protein-splicing catalytic site; other site 935593001041 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 935593001042 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 935593001043 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935593001044 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 935593001045 protein-splicing catalytic site; other site 935593001046 thioester formation/cholesterol transfer; other site 935593001047 Pretoxin HINT domain; Region: PT-HINT; pfam07591 935593001048 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 935593001049 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 935593001050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935593001051 FeS/SAM binding site; other site 935593001052 HemN C-terminal domain; Region: HemN_C; pfam06969 935593001053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 935593001054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 935593001055 ligand binding site [chemical binding]; other site 935593001056 flexible hinge region; other site 935593001057 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 935593001058 putative switch regulator; other site 935593001059 non-specific DNA interactions [nucleotide binding]; other site 935593001060 DNA binding site [nucleotide binding] 935593001061 sequence specific DNA binding site [nucleotide binding]; other site 935593001062 putative cAMP binding site [chemical binding]; other site 935593001063 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 935593001064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935593001065 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 935593001066 substrate binding site [chemical binding]; other site 935593001067 dimerization interface [polypeptide binding]; other site 935593001068 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 935593001069 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 935593001070 ligand binding site [chemical binding]; other site 935593001071 thiamine-monophosphate kinase; Region: thiL; TIGR01379 935593001072 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 935593001073 ATP binding site [chemical binding]; other site 935593001074 dimerization interface [polypeptide binding]; other site 935593001075 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 935593001076 tetramer interfaces [polypeptide binding]; other site 935593001077 binuclear metal-binding site [ion binding]; other site 935593001078 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 935593001079 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935593001080 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935593001081 ABC transporter; Region: ABC_tran_2; pfam12848 935593001082 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935593001083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935593001084 putative substrate translocation pore; other site 935593001085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935593001086 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 935593001087 active site 935593001088 catalytic residues [active] 935593001089 maltose phosphorylase; Provisional; Region: PRK13807 935593001090 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 935593001091 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 935593001092 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 935593001093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935593001094 motif II; other site 935593001095 L-aspartate oxidase; Provisional; Region: PRK06175 935593001096 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 935593001097 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 935593001098 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 935593001099 quinolinate synthetase; Provisional; Region: PRK09375 935593001100 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 935593001101 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 935593001102 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 935593001103 dimerization interface [polypeptide binding]; other site 935593001104 active site 935593001105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935593001106 dimerization interface [polypeptide binding]; other site 935593001107 putative DNA binding site [nucleotide binding]; other site 935593001108 putative Zn2+ binding site [ion binding]; other site 935593001109 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 935593001110 putative catalytic site [active] 935593001111 putative phosphate binding site [ion binding]; other site 935593001112 active site 935593001113 metal binding site A [ion binding]; metal-binding site 935593001114 DNA binding site [nucleotide binding] 935593001115 putative AP binding site [nucleotide binding]; other site 935593001116 putative metal binding site B [ion binding]; other site 935593001117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935593001118 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935593001119 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 935593001120 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 935593001121 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 935593001122 Glutamate binding site [chemical binding]; other site 935593001123 NAD binding site [chemical binding]; other site 935593001124 catalytic residues [active] 935593001125 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 935593001126 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 935593001127 Na binding site [ion binding]; other site 935593001128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 935593001129 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 935593001130 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 935593001131 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 935593001132 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 935593001133 cell division protein FtsN; Region: ftsN; TIGR02223 935593001134 Sporulation related domain; Region: SPOR; pfam05036 935593001135 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 935593001136 catalytic residues [active] 935593001137 hinge region; other site 935593001138 alpha helical domain; other site 935593001139 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 935593001140 Uncharacterized conserved protein [Function unknown]; Region: COG1565 935593001141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 935593001142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 935593001143 MraZ protein; Region: MraZ; pfam02381 935593001144 MraZ protein; Region: MraZ; pfam02381 935593001145 MraW methylase family; Region: Methyltransf_5; cl17771 935593001146 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 935593001147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 935593001148 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 935593001149 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 935593001150 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 935593001151 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 935593001152 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935593001153 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935593001154 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935593001155 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 935593001156 Sulfatase; Region: Sulfatase; pfam00884 935593001157 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935593001158 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 935593001159 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935593001160 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935593001161 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 935593001162 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 935593001163 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 935593001164 Mg++ binding site [ion binding]; other site 935593001165 putative catalytic motif [active] 935593001166 putative substrate binding site [chemical binding]; other site 935593001167 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04308 935593001168 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935593001169 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935593001170 cell division protein FtsW; Region: ftsW; TIGR02614 935593001171 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 935593001172 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 935593001173 active site 935593001174 homodimer interface [polypeptide binding]; other site 935593001175 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 935593001176 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935593001177 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935593001178 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935593001179 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 935593001180 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 935593001181 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935593001182 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 935593001183 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 935593001184 Cell division protein FtsQ; Region: FtsQ; pfam03799 935593001185 cell division protein FtsA; Region: ftsA; TIGR01174 935593001186 Cell division protein FtsA; Region: FtsA; smart00842 935593001187 Cell division protein FtsA; Region: FtsA; pfam14450 935593001188 cell division protein FtsZ; Validated; Region: PRK09330 935593001189 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 935593001190 nucleotide binding site [chemical binding]; other site 935593001191 SulA interaction site; other site 935593001192 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 935593001193 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 935593001194 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 935593001195 tetramer interface [polypeptide binding]; other site 935593001196 active site 935593001197 Mg2+/Mn2+ binding site [ion binding]; other site 935593001198 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 935593001199 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 935593001200 dimer interface [polypeptide binding]; other site 935593001201 active site 935593001202 citrylCoA binding site [chemical binding]; other site 935593001203 oxalacetate/citrate binding site [chemical binding]; other site 935593001204 coenzyme A binding site [chemical binding]; other site 935593001205 catalytic triad [active] 935593001206 hypothetical protein; Provisional; Region: PRK10621 935593001207 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 935593001208 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 935593001209 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 935593001210 substrate binding site [chemical binding]; other site 935593001211 ligand binding site [chemical binding]; other site 935593001212 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 935593001213 substrate binding site [chemical binding]; other site 935593001214 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 935593001215 propionate/acetate kinase; Provisional; Region: PRK12379 935593001216 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 935593001217 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 935593001218 Transcriptional regulator; Region: Rrf2; cl17282 935593001219 Rrf2 family protein; Region: rrf2_super; TIGR00738 935593001220 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 935593001221 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 935593001222 prephenate dehydrogenase; Validated; Region: PRK08507 935593001223 Predicted amidohydrolase [General function prediction only]; Region: COG0388 935593001224 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 935593001225 putative active site [active] 935593001226 catalytic triad [active] 935593001227 dimer interface [polypeptide binding]; other site 935593001228 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935593001229 EamA-like transporter family; Region: EamA; pfam00892 935593001230 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 935593001231 EamA-like transporter family; Region: EamA; pfam00892 935593001232 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 935593001233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935593001234 putative substrate translocation pore; other site 935593001235 chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807 935593001236 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 935593001237 Prephenate dehydratase; Region: PDT; pfam00800 935593001238 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 935593001239 putative L-Phe binding site [chemical binding]; other site 935593001240 Recombination protein O N terminal; Region: RecO_N; pfam11967 935593001241 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 935593001242 Recombination protein O C terminal; Region: RecO_C; pfam02565 935593001243 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 935593001244 active site 935593001245 hydrophilic channel; other site 935593001246 dimerization interface [polypeptide binding]; other site 935593001247 catalytic residues [active] 935593001248 active site lid [active] 935593001249 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 935593001250 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 935593001251 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 935593001252 active site 935593001253 8-oxo-dGMP binding site [chemical binding]; other site 935593001254 nudix motif; other site 935593001255 metal binding site [ion binding]; metal-binding site 935593001256 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935593001257 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 935593001258 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 935593001259 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 935593001260 Fic family protein [Function unknown]; Region: COG3177 935593001261 Fic/DOC family; Region: Fic; pfam02661 935593001262 AMIN domain; Region: AMIN; pfam11741 935593001263 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 935593001264 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 935593001265 active site 935593001266 metal binding site [ion binding]; metal-binding site 935593001267 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 935593001268 glutamate racemase; Provisional; Region: PRK00865 935593001269 Fic family protein [Function unknown]; Region: COG3177 935593001270 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 935593001271 Fic/DOC family; Region: Fic; pfam02661 935593001272 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935593001273 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 935593001274 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935593001275 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935593001276 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 935593001277 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935593001278 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 935593001279 Uncharacterized conserved protein [Function unknown]; Region: COG2928 935593001280 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 935593001281 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 935593001282 dimer interface [polypeptide binding]; other site 935593001283 anticodon binding site; other site 935593001284 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 935593001285 homodimer interface [polypeptide binding]; other site 935593001286 motif 1; other site 935593001287 active site 935593001288 motif 2; other site 935593001289 GAD domain; Region: GAD; pfam02938 935593001290 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 935593001291 motif 3; other site 935593001292 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 935593001293 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 935593001294 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 935593001295 dimer interface [polypeptide binding]; other site 935593001296 active site 935593001297 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935593001298 catalytic residues [active] 935593001299 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 935593001300 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 935593001301 agmatinase; Region: agmatinase; TIGR01230 935593001302 oligomer interface [polypeptide binding]; other site 935593001303 putative active site [active] 935593001304 Mn binding site [ion binding]; other site 935593001305 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 935593001306 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 935593001307 transmembrane helices; other site 935593001308 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 935593001309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 935593001310 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 935593001311 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 935593001312 substrate-cofactor binding pocket; other site 935593001313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593001314 catalytic residue [active] 935593001315 Protein of unknown function (DUF452); Region: DUF452; cl01062 935593001316 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 935593001317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593001318 S-adenosylmethionine binding site [chemical binding]; other site 935593001319 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 935593001320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935593001321 active site 935593001322 phosphorylation site [posttranslational modification] 935593001323 intermolecular recognition site; other site 935593001324 dimerization interface [polypeptide binding]; other site 935593001325 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 935593001326 G1 box; other site 935593001327 GTP/Mg2+ binding site [chemical binding]; other site 935593001328 G2 box; other site 935593001329 Switch I region; other site 935593001330 G3 box; other site 935593001331 Switch II region; other site 935593001332 G4 box; other site 935593001333 G5 box; other site 935593001334 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 935593001335 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935593001336 Protein of unknown function (DUF1132); Region: DUF1132; pfam06575 935593001337 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935593001338 Replication initiation factor; Region: Rep_trans; pfam02486 935593001339 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 935593001340 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935593001341 HlyD family secretion protein; Region: HlyD_3; pfam13437 935593001342 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 935593001343 DDE superfamily endonuclease; Region: DDE_3; pfam13358 935593001344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 935593001345 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 935593001346 HD domain; Region: HD_4; pfam13328 935593001347 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 935593001348 synthetase active site [active] 935593001349 NTP binding site [chemical binding]; other site 935593001350 metal binding site [ion binding]; metal-binding site 935593001351 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 935593001352 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 935593001353 Glutaredoxin 2 [Posttranslational modification, protein turnover, chaperones]; Region: GrxB; COG2999 935593001354 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 935593001355 C-terminal domain interface [polypeptide binding]; other site 935593001356 GSH binding site (G-site) [chemical binding]; other site 935593001357 catalytic residues [active] 935593001358 putative dimer interface [polypeptide binding]; other site 935593001359 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 935593001360 N-terminal domain interface [polypeptide binding]; other site 935593001361 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 935593001362 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 935593001363 Peptidase family M50; Region: Peptidase_M50; pfam02163 935593001364 active site 935593001365 putative substrate binding region [chemical binding]; other site 935593001366 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 935593001367 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 935593001368 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 935593001369 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 935593001370 TolR protein; Region: tolR; TIGR02801 935593001371 TIGR01244 family protein; Region: TIGR01244 935593001372 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 935593001373 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 935593001374 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 935593001375 protein binding site [polypeptide binding]; other site 935593001376 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 935593001377 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 935593001378 Low-spin heme binding site [chemical binding]; other site 935593001379 Putative water exit pathway; other site 935593001380 Binuclear center (active site) [active] 935593001381 Putative proton exit pathway; other site 935593001382 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 935593001383 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 935593001384 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 935593001385 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 935593001386 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 935593001387 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 935593001388 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 935593001389 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 935593001390 AbgT putative transporter family; Region: ABG_transport; pfam03806 935593001391 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 935593001392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935593001393 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 935593001394 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 935593001395 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935593001396 HlyD family secretion protein; Region: HlyD_3; pfam13437 935593001397 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 935593001398 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 935593001399 L-lactate permease; Region: Lactate_perm; cl00701 935593001400 Transcriptional regulators [Transcription]; Region: FadR; COG2186 935593001401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935593001402 DNA-binding site [nucleotide binding]; DNA binding site 935593001403 FCD domain; Region: FCD; pfam07729 935593001404 glutamate dehydrogenase; Provisional; Region: PRK09414 935593001405 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 935593001406 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 935593001407 NAD(P) binding site [chemical binding]; other site 935593001408 thymidylate synthase; Reviewed; Region: thyA; PRK01827 935593001409 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 935593001410 dimerization interface [polypeptide binding]; other site 935593001411 active site 935593001412 ApbE family; Region: ApbE; pfam02424 935593001413 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 935593001414 Na2 binding site [ion binding]; other site 935593001415 putative substrate binding site 1 [chemical binding]; other site 935593001416 Na binding site 1 [ion binding]; other site 935593001417 putative substrate binding site 2 [chemical binding]; other site 935593001418 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935593001419 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 935593001420 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 935593001421 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 935593001422 putative metal binding site; other site 935593001423 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 935593001424 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 935593001425 dimer interface [polypeptide binding]; other site 935593001426 active site 935593001427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935593001428 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 935593001429 Predicted membrane protein [Function unknown]; Region: COG4648 935593001430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4899 935593001431 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 935593001432 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 935593001433 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 935593001434 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 935593001435 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 935593001436 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 935593001437 dihydropteroate synthase; Region: DHPS; TIGR01496 935593001438 substrate binding pocket [chemical binding]; other site 935593001439 dimer interface [polypeptide binding]; other site 935593001440 inhibitor binding site; inhibition site 935593001441 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 935593001442 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 935593001443 active site 935593001444 substrate binding site [chemical binding]; other site 935593001445 metal binding site [ion binding]; metal-binding site 935593001446 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 935593001447 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 935593001448 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 935593001449 active site 935593001450 homodimer interface [polypeptide binding]; other site 935593001451 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 935593001452 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 935593001453 active site 935593001454 peptide chain release factor 1; Validated; Region: prfA; PRK00591 935593001455 This domain is found in peptide chain release factors; Region: PCRF; smart00937 935593001456 RF-1 domain; Region: RF-1; pfam00472 935593001457 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 935593001458 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 935593001459 putative ligand binding site [chemical binding]; other site 935593001460 putative NAD binding site [chemical binding]; other site 935593001461 catalytic site [active] 935593001462 seryl-tRNA synthetase; Provisional; Region: PRK05431 935593001463 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 935593001464 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 935593001465 dimer interface [polypeptide binding]; other site 935593001466 active site 935593001467 motif 1; other site 935593001468 motif 2; other site 935593001469 motif 3; other site 935593001470 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 935593001471 putative active site [active] 935593001472 Ap4A binding site [chemical binding]; other site 935593001473 nudix motif; other site 935593001474 putative metal binding site [ion binding]; other site 935593001475 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 935593001476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935593001477 ATP binding site [chemical binding]; other site 935593001478 Mg2+ binding site [ion binding]; other site 935593001479 G-X-G motif; other site 935593001480 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 935593001481 anchoring element; other site 935593001482 dimer interface [polypeptide binding]; other site 935593001483 ATP binding site [chemical binding]; other site 935593001484 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 935593001485 active site 935593001486 metal binding site [ion binding]; metal-binding site 935593001487 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 935593001488 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 935593001489 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 935593001490 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 935593001491 Tetramer interface [polypeptide binding]; other site 935593001492 active site 935593001493 FMN-binding site [chemical binding]; other site 935593001494 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 935593001495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593001496 S-adenosylmethionine binding site [chemical binding]; other site 935593001497 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 935593001498 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935593001499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593001500 homodimer interface [polypeptide binding]; other site 935593001501 catalytic residue [active] 935593001502 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 935593001503 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 935593001504 glycine dehydrogenase; Provisional; Region: PRK05367 935593001505 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 935593001506 tetramer interface [polypeptide binding]; other site 935593001507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593001508 catalytic residue [active] 935593001509 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 935593001510 tetramer interface [polypeptide binding]; other site 935593001511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593001512 catalytic residue [active] 935593001513 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 935593001514 active site 935593001515 catalytic triad [active] 935593001516 oxyanion hole [active] 935593001517 switch loop; other site 935593001518 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 935593001519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 935593001520 Protein of unknown function (DUF330); Region: DUF330; pfam03886 935593001521 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 935593001522 mce related protein; Region: MCE; pfam02470 935593001523 mce related protein; Region: MCE; pfam02470 935593001524 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 935593001525 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 935593001526 Paraquat-inducible protein A; Region: PqiA; pfam04403 935593001527 Paraquat-inducible protein A; Region: PqiA; pfam04403 935593001528 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 935593001529 heme binding pocket [chemical binding]; other site 935593001530 heme ligand [chemical binding]; other site 935593001531 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 935593001532 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 935593001533 putative active site [active] 935593001534 putative protease; Provisional; Region: PRK15452 935593001535 Peptidase family U32; Region: Peptidase_U32; pfam01136 935593001536 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 935593001537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935593001538 active site 935593001539 motif I; other site 935593001540 motif II; other site 935593001541 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 935593001542 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935593001543 active site 935593001544 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 935593001545 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 935593001546 catalytic site [active] 935593001547 G-X2-G-X-G-K; other site 935593001548 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 935593001549 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 935593001550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935593001551 Zn2+ binding site [ion binding]; other site 935593001552 Mg2+ binding site [ion binding]; other site 935593001553 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 935593001554 synthetase active site [active] 935593001555 NTP binding site [chemical binding]; other site 935593001556 metal binding site [ion binding]; metal-binding site 935593001557 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 935593001558 ACT domain; Region: ACT_4; pfam13291 935593001559 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 935593001560 Flavoprotein; Region: Flavoprotein; pfam02441 935593001561 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 935593001562 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 935593001563 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 935593001564 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 935593001565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593001566 S-adenosylmethionine binding site [chemical binding]; other site 935593001567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 935593001568 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 935593001569 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 935593001570 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 935593001571 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 935593001572 active site 935593001573 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935593001574 substrate binding site [chemical binding]; other site 935593001575 catalytic residues [active] 935593001576 dimer interface [polypeptide binding]; other site 935593001577 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 935593001578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935593001579 putative DNA binding site [nucleotide binding]; other site 935593001580 putative Zn2+ binding site [ion binding]; other site 935593001581 AsnC family; Region: AsnC_trans_reg; pfam01037 935593001582 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 935593001583 hypothetical protein; Validated; Region: PRK00110 935593001584 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935593001585 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 935593001586 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 935593001587 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 935593001588 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 935593001589 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 935593001590 G1 box; other site 935593001591 GTP/Mg2+ binding site [chemical binding]; other site 935593001592 G2 box; other site 935593001593 Switch I region; other site 935593001594 G3 box; other site 935593001595 Switch II region; other site 935593001596 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 935593001597 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 935593001598 translation initiation factor IF-2; Region: IF-2; TIGR00487 935593001599 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 935593001600 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 935593001601 G1 box; other site 935593001602 putative GEF interaction site [polypeptide binding]; other site 935593001603 GTP/Mg2+ binding site [chemical binding]; other site 935593001604 Switch I region; other site 935593001605 G2 box; other site 935593001606 G3 box; other site 935593001607 Switch II region; other site 935593001608 G4 box; other site 935593001609 G5 box; other site 935593001610 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 935593001611 Translation-initiation factor 2; Region: IF-2; pfam11987 935593001612 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 935593001613 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 935593001614 NusA N-terminal domain; Region: NusA_N; pfam08529 935593001615 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 935593001616 RNA binding site [nucleotide binding]; other site 935593001617 homodimer interface [polypeptide binding]; other site 935593001618 NusA-like KH domain; Region: KH_5; pfam13184 935593001619 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 935593001620 G-X-X-G motif; other site 935593001621 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 935593001622 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 935593001623 ribosome maturation protein RimP; Reviewed; Region: PRK00092 935593001624 Sm and related proteins; Region: Sm_like; cl00259 935593001625 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 935593001626 putative oligomer interface [polypeptide binding]; other site 935593001627 putative RNA binding site [nucleotide binding]; other site 935593001628 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 935593001629 homodimer interface [polypeptide binding]; other site 935593001630 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 935593001631 substrate-cofactor binding pocket; other site 935593001632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593001633 catalytic residue [active] 935593001634 putative metal dependent hydrolase; Provisional; Region: PRK11598 935593001635 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 935593001636 Sulfatase; Region: Sulfatase; pfam00884 935593001637 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 935593001638 putative FMN binding site [chemical binding]; other site 935593001639 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935593001640 Uncharacterized conserved protein [Function unknown]; Region: COG1262 935593001641 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 935593001642 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 935593001643 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 935593001644 catalytic residues [active] 935593001645 dimer interface [polypeptide binding]; other site 935593001646 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 935593001647 dimer interface [polypeptide binding]; other site 935593001648 catalytic triad [active] 935593001649 HIT domain; Region: HIT; pfam01230 935593001650 HIT family signature motif; other site 935593001651 catalytic residue [active] 935593001652 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 935593001653 RNA/DNA hybrid binding site [nucleotide binding]; other site 935593001654 active site 935593001655 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 935593001656 tellurite resistance protein TehB; Provisional; Region: PRK12335 935593001657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 935593001658 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 935593001659 dimer interface [polypeptide binding]; other site 935593001660 substrate binding site [chemical binding]; other site 935593001661 ATP binding site [chemical binding]; other site 935593001662 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 935593001663 TrkA-N domain; Region: TrkA_N; pfam02254 935593001664 TrkA-C domain; Region: TrkA_C; pfam02080 935593001665 TrkA-N domain; Region: TrkA_N; pfam02254 935593001666 TrkA-C domain; Region: TrkA_C; pfam02080 935593001667 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 935593001668 Fumarase C-terminus; Region: Fumerase_C; pfam05683 935593001669 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 935593001670 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 935593001671 substrate binding pocket [chemical binding]; other site 935593001672 membrane-bound complex binding site; other site 935593001673 hinge residues; other site 935593001674 O-succinylhomoserine sulfhydrylase; Region: O_suc_HS_sulf; TIGR01325 935593001675 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 935593001676 homodimer interface [polypeptide binding]; other site 935593001677 substrate-cofactor binding pocket; other site 935593001678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593001679 catalytic residue [active] 935593001680 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 935593001681 Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445 935593001682 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 935593001683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935593001684 active site 935593001685 phosphorylation site [posttranslational modification] 935593001686 intermolecular recognition site; other site 935593001687 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 935593001688 Predicted permeases [General function prediction only]; Region: COG0730 935593001689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935593001690 dimer interface [polypeptide binding]; other site 935593001691 phosphorylation site [posttranslational modification] 935593001692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 935593001693 Mg2+ binding site [ion binding]; other site 935593001694 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 935593001695 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 935593001696 CAP-like domain; other site 935593001697 active site 935593001698 primary dimer interface [polypeptide binding]; other site 935593001699 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935593001700 catalytic core [active] 935593001701 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935593001702 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 935593001703 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 935593001704 gating phenylalanine in ion channel; other site 935593001705 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935593001706 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935593001707 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 935593001708 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935593001709 cofactor binding site; other site 935593001710 DNA binding site [nucleotide binding] 935593001711 substrate interaction site [chemical binding]; other site 935593001712 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 935593001713 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 935593001714 motif 1; other site 935593001715 active site 935593001716 motif 2; other site 935593001717 motif 3; other site 935593001718 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 935593001719 DHHA1 domain; Region: DHHA1; pfam02272 935593001720 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 935593001721 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935593001722 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 935593001723 EamA-like transporter family; Region: EamA; pfam00892 935593001724 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 935593001725 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 935593001726 Cupin; Region: Cupin_6; pfam12852 935593001727 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 935593001728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 935593001729 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 935593001730 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 935593001731 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 935593001732 putative inner membrane peptidase; Provisional; Region: PRK11778 935593001733 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 935593001734 tandem repeat interface [polypeptide binding]; other site 935593001735 oligomer interface [polypeptide binding]; other site 935593001736 active site residues [active] 935593001737 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 935593001738 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 935593001739 MarR family; Region: MarR_2; pfam12802 935593001740 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 935593001741 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 935593001742 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 935593001743 putative active site pocket [active] 935593001744 4-fold oligomerization interface [polypeptide binding]; other site 935593001745 metal binding residues [ion binding]; metal-binding site 935593001746 3-fold/trimer interface [polypeptide binding]; other site 935593001747 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 935593001748 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935593001749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593001750 homodimer interface [polypeptide binding]; other site 935593001751 catalytic residue [active] 935593001752 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 935593001753 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 935593001754 NAD binding site [chemical binding]; other site 935593001755 dimerization interface [polypeptide binding]; other site 935593001756 product binding site; other site 935593001757 substrate binding site [chemical binding]; other site 935593001758 zinc binding site [ion binding]; other site 935593001759 catalytic residues [active] 935593001760 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 935593001761 GIY-YIG motif/motif A; other site 935593001762 putative active site [active] 935593001763 putative metal binding site [ion binding]; other site 935593001764 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 935593001765 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 935593001766 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 935593001767 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935593001768 Cu(I) binding site [ion binding]; other site 935593001769 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 935593001770 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 935593001771 PYR/PP interface [polypeptide binding]; other site 935593001772 dimer interface [polypeptide binding]; other site 935593001773 TPP binding site [chemical binding]; other site 935593001774 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 935593001775 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 935593001776 TPP-binding site [chemical binding]; other site 935593001777 dimer interface [polypeptide binding]; other site 935593001778 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 935593001779 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 935593001780 putative valine binding site [chemical binding]; other site 935593001781 dimer interface [polypeptide binding]; other site 935593001782 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 935593001783 Uncharacterized conserved protein [Function unknown]; Region: COG1359 935593001784 ketol-acid reductoisomerase; Provisional; Region: PRK05479 935593001785 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 935593001786 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 935593001787 ornithine carbamoyltransferase; Validated; Region: PRK02102 935593001788 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 935593001789 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 935593001790 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 935593001791 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 935593001792 substrate binding site [chemical binding]; other site 935593001793 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 935593001794 substrate binding site [chemical binding]; other site 935593001795 ligand binding site [chemical binding]; other site 935593001796 Predicted permeases [General function prediction only]; Region: COG0795 935593001797 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 935593001798 Predicted permeases [General function prediction only]; Region: COG0795 935593001799 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 935593001800 multifunctional aminopeptidase A; Provisional; Region: PRK00913 935593001801 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 935593001802 interface (dimer of trimers) [polypeptide binding]; other site 935593001803 Substrate-binding/catalytic site; other site 935593001804 Zn-binding sites [ion binding]; other site 935593001805 DNA polymerase III, chi subunit [DNA replication, recombination, and repair]; Region: HolC; COG2927 935593001806 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 935593001807 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 935593001808 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935593001809 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 935593001810 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 935593001811 active site 935593001812 substrate binding site [chemical binding]; other site 935593001813 cosubstrate binding site; other site 935593001814 catalytic site [active] 935593001815 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 935593001816 OsmC-like protein; Region: OsmC; cl00767 935593001817 Transcriptional regulators [Transcription]; Region: GntR; COG1802 935593001818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935593001819 DNA-binding site [nucleotide binding]; DNA binding site 935593001820 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 935593001821 Predicted membrane protein [Function unknown]; Region: COG2431 935593001822 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 935593001823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935593001824 putative DNA binding site [nucleotide binding]; other site 935593001825 putative Zn2+ binding site [ion binding]; other site 935593001826 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 935593001827 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 935593001828 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935593001829 active site 935593001830 HIGH motif; other site 935593001831 nucleotide binding site [chemical binding]; other site 935593001832 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 935593001833 KMSKS motif; other site 935593001834 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 935593001835 glutathione synthetase; Provisional; Region: PRK05246 935593001836 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 935593001837 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 935593001838 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 935593001839 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 935593001840 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 935593001841 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 935593001842 Ligand Binding Site [chemical binding]; other site 935593001843 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 935593001844 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 935593001845 acyl-activating enzyme (AAE) consensus motif; other site 935593001846 putative AMP binding site [chemical binding]; other site 935593001847 putative active site [active] 935593001848 putative CoA binding site [chemical binding]; other site 935593001849 CTP synthetase; Validated; Region: pyrG; PRK05380 935593001850 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 935593001851 Catalytic site [active] 935593001852 active site 935593001853 UTP binding site [chemical binding]; other site 935593001854 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 935593001855 active site 935593001856 putative oxyanion hole; other site 935593001857 catalytic triad [active] 935593001858 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935593001859 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935593001860 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 935593001861 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935593001862 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935593001863 Transposase domain (DUF772); Region: DUF772; pfam05598 935593001864 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593001865 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 935593001866 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 935593001867 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 935593001868 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 935593001869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935593001870 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 935593001871 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935593001872 DNA binding residues [nucleotide binding] 935593001873 DNA primase; Validated; Region: dnaG; PRK05667 935593001874 CHC2 zinc finger; Region: zf-CHC2; pfam01807 935593001875 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 935593001876 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 935593001877 active site 935593001878 metal binding site [ion binding]; metal-binding site 935593001879 interdomain interaction site; other site 935593001880 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 935593001881 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 935593001882 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 935593001883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 935593001884 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 935593001885 SEC-C motif; Region: SEC-C; pfam02810 935593001886 Protein of unknown function (DUF721); Region: DUF721; pfam05258 935593001887 Azurin [Energy production and conversion]; Region: COG3241 935593001888 Hemerythrin-like domain; Region: Hr-like; cd12108 935593001889 Fe binding site [ion binding]; other site 935593001890 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 935593001891 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 935593001892 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 935593001893 metal binding site [ion binding]; metal-binding site 935593001894 dimer interface [polypeptide binding]; other site 935593001895 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 935593001896 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 935593001897 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 935593001898 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 935593001899 DNA binding site [nucleotide binding] 935593001900 active site 935593001901 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 935593001902 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 935593001903 putative active site [active] 935593001904 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 935593001905 SmpB-tmRNA interface; other site 935593001906 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 935593001907 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593001908 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 935593001909 FAD binding domain; Region: FAD_binding_4; pfam01565 935593001910 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 935593001911 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935593001912 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 935593001913 active site lid residues [active] 935593001914 substrate binding pocket [chemical binding]; other site 935593001915 catalytic residues [active] 935593001916 substrate-Mg2+ binding site; other site 935593001917 aspartate-rich region 1; other site 935593001918 aspartate-rich region 2; other site 935593001919 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 935593001920 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 935593001921 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 935593001922 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 935593001923 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 935593001924 DsbD alpha interface [polypeptide binding]; other site 935593001925 catalytic residues [active] 935593001926 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 935593001927 propionate/acetate kinase; Provisional; Region: PRK12379 935593001928 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 935593001929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935593001930 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 935593001931 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 935593001932 active site 935593001933 catalytic site [active] 935593001934 substrate binding site [chemical binding]; other site 935593001935 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 935593001936 substrate binding site; other site 935593001937 dimer interface; other site 935593001938 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 935593001939 homotrimer interaction site [polypeptide binding]; other site 935593001940 zinc binding site [ion binding]; other site 935593001941 CDP-binding sites; other site 935593001942 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 935593001943 tetramer (dimer of dimers) interface [polypeptide binding]; other site 935593001944 active site 935593001945 dimer interface [polypeptide binding]; other site 935593001946 Staphylococcal nuclease homologues; Region: SNc; smart00318 935593001947 Catalytic site; other site 935593001948 Staphylococcal nuclease homologue; Region: SNase; pfam00565 935593001949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935593001950 dimer interface [polypeptide binding]; other site 935593001951 conserved gate region; other site 935593001952 putative PBP binding loops; other site 935593001953 ABC-ATPase subunit interface; other site 935593001954 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 935593001955 Sulfatase; Region: Sulfatase; cl17466 935593001956 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 935593001957 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 935593001958 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 935593001959 active site 935593001960 HIGH motif; other site 935593001961 KMSK motif region; other site 935593001962 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 935593001963 tRNA binding surface [nucleotide binding]; other site 935593001964 anticodon binding site; other site 935593001965 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 935593001966 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 935593001967 active site 935593001968 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 935593001969 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 935593001970 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 935593001971 putative ATP binding site [chemical binding]; other site 935593001972 putative substrate interface [chemical binding]; other site 935593001973 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 935593001974 Ligand Binding Site [chemical binding]; other site 935593001975 ribonuclease PH; Reviewed; Region: rph; PRK00173 935593001976 Ribonuclease PH; Region: RNase_PH_bact; cd11362 935593001977 hexamer interface [polypeptide binding]; other site 935593001978 active site 935593001979 aspartate kinase; Reviewed; Region: PRK06635 935593001980 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 935593001981 putative nucleotide binding site [chemical binding]; other site 935593001982 putative catalytic residues [active] 935593001983 putative Mg ion binding site [ion binding]; other site 935593001984 putative aspartate binding site [chemical binding]; other site 935593001985 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 935593001986 putative allosteric regulatory site; other site 935593001987 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 935593001988 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 935593001989 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 935593001990 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935593001991 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 935593001992 pseudouridine synthase; Region: TIGR00093 935593001993 probable active site [active] 935593001994 Uncharacterized small protein [Function unknown]; Region: COG2879 935593001995 carbon starvation protein A; Provisional; Region: PRK15015 935593001996 Carbon starvation protein CstA; Region: CstA; pfam02554 935593001997 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 935593001998 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 935593001999 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 935593002000 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 935593002001 tetramerization interface [polypeptide binding]; other site 935593002002 NAD(P) binding site [chemical binding]; other site 935593002003 catalytic residues [active] 935593002004 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 935593002005 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 935593002006 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 935593002007 Transporter associated domain; Region: CorC_HlyC; smart01091 935593002008 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 935593002009 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935593002010 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935593002011 Peptidase family M23; Region: Peptidase_M23; pfam01551 935593002012 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 935593002013 recombination regulator RecX; Reviewed; Region: recX; PRK00117 935593002014 phosphoglycolate phosphatase; Provisional; Region: PRK13222 935593002015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935593002016 motif II; other site 935593002017 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 935593002018 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 935593002019 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 935593002020 NAD(P) binding site [chemical binding]; other site 935593002021 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 935593002022 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 935593002023 active site 1 [active] 935593002024 dimer interface [polypeptide binding]; other site 935593002025 hexamer interface [polypeptide binding]; other site 935593002026 active site 2 [active] 935593002027 aminotransferase AlaT; Validated; Region: PRK09265 935593002028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935593002029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593002030 homodimer interface [polypeptide binding]; other site 935593002031 catalytic residue [active] 935593002032 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 935593002033 Clp amino terminal domain; Region: Clp_N; pfam02861 935593002034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593002035 Walker A motif; other site 935593002036 ATP binding site [chemical binding]; other site 935593002037 Walker B motif; other site 935593002038 arginine finger; other site 935593002039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593002040 Walker A motif; other site 935593002041 ATP binding site [chemical binding]; other site 935593002042 Walker B motif; other site 935593002043 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 935593002044 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 935593002045 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 935593002046 active site 935593002047 HIGH motif; other site 935593002048 dimer interface [polypeptide binding]; other site 935593002049 KMSKS motif; other site 935593002050 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 935593002051 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 935593002052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935593002053 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935593002054 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935593002055 Zonular occludens toxin (Zot); Region: Zot; cl17485 935593002056 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 935593002057 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935593002058 Protein of unknown function (DUF1132); Region: DUF1132; pfam06575 935593002059 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935593002060 Replication initiation factor; Region: Rep_trans; pfam02486 935593002061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 935593002062 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 935593002063 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935593002064 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935593002065 catalytic residue [active] 935593002066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935593002067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935593002068 putative substrate translocation pore; other site 935593002069 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 935593002070 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 935593002071 dimer interface [polypeptide binding]; other site 935593002072 ssDNA binding site [nucleotide binding]; other site 935593002073 tetramer (dimer of dimers) interface [polypeptide binding]; other site 935593002074 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 935593002075 EamA-like transporter family; Region: EamA; pfam00892 935593002076 fumarate hydratase; Reviewed; Region: fumC; PRK00485 935593002077 Class II fumarases; Region: Fumarase_classII; cd01362 935593002078 active site 935593002079 tetramer interface [polypeptide binding]; other site 935593002080 transketolase; Reviewed; Region: PRK12753 935593002081 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 935593002082 TPP-binding site [chemical binding]; other site 935593002083 dimer interface [polypeptide binding]; other site 935593002084 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 935593002085 PYR/PP interface [polypeptide binding]; other site 935593002086 dimer interface [polypeptide binding]; other site 935593002087 TPP binding site [chemical binding]; other site 935593002088 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 935593002089 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 935593002090 4Fe-4S binding domain; Region: Fer4_5; pfam12801 935593002091 4Fe-4S binding domain; Region: Fer4_3; pfam12798 935593002092 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 935593002093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 935593002094 FixH; Region: FixH; pfam05751 935593002095 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 935593002096 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 935593002097 FMN binding site [chemical binding]; other site 935593002098 substrate binding site [chemical binding]; other site 935593002099 putative catalytic residue [active] 935593002100 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 935593002101 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 935593002102 active site 935593002103 catalytic site [active] 935593002104 substrate binding site [chemical binding]; other site 935593002105 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 935593002106 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 935593002107 FAD binding pocket [chemical binding]; other site 935593002108 FAD binding motif [chemical binding]; other site 935593002109 phosphate binding motif [ion binding]; other site 935593002110 beta-alpha-beta structure motif; other site 935593002111 NAD binding pocket [chemical binding]; other site 935593002112 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 935593002113 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935593002114 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 935593002115 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935593002116 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 935593002117 active site 935593002118 DNA polymerase IV; Validated; Region: PRK02406 935593002119 DNA binding site [nucleotide binding] 935593002120 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 935593002121 Family description; Region: UvrD_C_2; pfam13538 935593002122 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 935593002123 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 935593002124 active site 935593002125 catalytic residue [active] 935593002126 dimer interface [polypeptide binding]; other site 935593002127 recombinase A; Provisional; Region: recA; PRK09354 935593002128 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 935593002129 hexamer interface [polypeptide binding]; other site 935593002130 Walker A motif; other site 935593002131 ATP binding site [chemical binding]; other site 935593002132 Walker B motif; other site 935593002133 hypothetical protein; Validated; Region: PRK00153 935593002134 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08691 935593002135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593002136 Walker A motif; other site 935593002137 ATP binding site [chemical binding]; other site 935593002138 Walker B motif; other site 935593002139 arginine finger; other site 935593002140 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 935593002141 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 935593002142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935593002143 ATP binding site [chemical binding]; other site 935593002144 Mg2+ binding site [ion binding]; other site 935593002145 G-X-G motif; other site 935593002146 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 935593002147 ATP binding site [chemical binding]; other site 935593002148 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 935593002149 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 935593002150 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 935593002151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593002152 S-adenosylmethionine binding site [chemical binding]; other site 935593002153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 935593002154 Tetratricopeptide repeat; Region: TPR_6; pfam13174 935593002155 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 935593002156 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 935593002157 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 935593002158 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 935593002159 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 935593002160 Uncharacterized conserved protein [Function unknown]; Region: COG1556 935593002161 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 935593002162 Cysteine-rich domain; Region: CCG; pfam02754 935593002163 Cysteine-rich domain; Region: CCG; pfam02754 935593002164 putative transporter; Provisional; Region: PRK10504 935593002165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935593002166 putative substrate translocation pore; other site 935593002167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935593002168 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 935593002169 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 935593002170 putative active site [active] 935593002171 catalytic site [active] 935593002172 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 935593002173 putative active site [active] 935593002174 catalytic site [active] 935593002175 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 935593002176 NlpC/P60 family; Region: NLPC_P60; pfam00877 935593002177 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 935593002178 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 935593002179 hinge; other site 935593002180 active site 935593002181 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 935593002182 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 935593002183 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 935593002184 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 935593002185 eyelet of channel; other site 935593002186 trimer interface [polypeptide binding]; other site 935593002187 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 935593002188 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 935593002189 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 935593002190 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 935593002191 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 935593002192 active site 935593002193 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 935593002194 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 935593002195 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 935593002196 dimer interface [polypeptide binding]; other site 935593002197 putative anticodon binding site; other site 935593002198 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 935593002199 motif 1; other site 935593002200 active site 935593002201 motif 2; other site 935593002202 motif 3; other site 935593002203 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935593002204 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935593002205 Catalytic site [active] 935593002206 Fic family protein [Function unknown]; Region: COG3177 935593002207 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 935593002208 Fic/DOC family; Region: Fic; pfam02661 935593002209 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 935593002210 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 935593002211 ATP binding site [chemical binding]; other site 935593002212 Mg++ binding site [ion binding]; other site 935593002213 motif III; other site 935593002214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935593002215 nucleotide binding region [chemical binding]; other site 935593002216 ATP-binding site [chemical binding]; other site 935593002217 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 935593002218 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 935593002219 FMN binding site [chemical binding]; other site 935593002220 active site 935593002221 catalytic residues [active] 935593002222 substrate binding site [chemical binding]; other site 935593002223 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 935593002224 DNA-binding protein Fis; Provisional; Region: PRK01905 935593002225 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 935593002226 active site 935593002227 putative DNA-binding cleft [nucleotide binding]; other site 935593002228 dimer interface [polypeptide binding]; other site 935593002229 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 935593002230 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 935593002231 putative acyl-acceptor binding pocket; other site 935593002232 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 935593002233 active site 935593002234 catalytic site [active] 935593002235 substrate binding site [chemical binding]; other site 935593002236 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 935593002237 aminopeptidase N; Provisional; Region: pepN; PRK14015 935593002238 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 935593002239 active site 935593002240 Zn binding site [ion binding]; other site 935593002241 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 935593002242 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 935593002243 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 935593002244 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 935593002245 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 935593002246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935593002247 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 935593002248 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 935593002249 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935593002250 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 935593002251 Walker A/P-loop; other site 935593002252 ATP binding site [chemical binding]; other site 935593002253 Q-loop/lid; other site 935593002254 ABC transporter signature motif; other site 935593002255 Walker B; other site 935593002256 D-loop; other site 935593002257 H-loop/switch region; other site 935593002258 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 935593002259 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 935593002260 E-class dimer interface [polypeptide binding]; other site 935593002261 P-class dimer interface [polypeptide binding]; other site 935593002262 active site 935593002263 Cu2+ binding site [ion binding]; other site 935593002264 Zn2+ binding site [ion binding]; other site 935593002265 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 935593002266 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 935593002267 minor groove reading motif; other site 935593002268 helix-hairpin-helix signature motif; other site 935593002269 substrate binding pocket [chemical binding]; other site 935593002270 active site 935593002271 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 935593002272 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 935593002273 DNA binding and oxoG recognition site [nucleotide binding] 935593002274 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 935593002275 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 935593002276 active site 935593002277 intersubunit interface [polypeptide binding]; other site 935593002278 catalytic residue [active] 935593002279 phosphogluconate dehydratase; Validated; Region: PRK09054 935593002280 6-phosphogluconate dehydratase; Region: edd; TIGR01196 935593002281 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 935593002282 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 935593002283 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 935593002284 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 935593002285 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 935593002286 putative active site [active] 935593002287 glucokinase; Provisional; Region: glk; PRK00292 935593002288 glucokinase, proteobacterial type; Region: glk; TIGR00749 935593002289 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 935593002290 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 935593002291 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 935593002292 putative active site [active] 935593002293 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 935593002294 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 935593002295 active site 935593002296 dimer interface [polypeptide binding]; other site 935593002297 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 935593002298 dimer interface [polypeptide binding]; other site 935593002299 active site 935593002300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935593002301 DNA gyrase subunit A; Validated; Region: PRK05560 935593002302 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 935593002303 CAP-like domain; other site 935593002304 active site 935593002305 primary dimer interface [polypeptide binding]; other site 935593002306 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935593002307 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935593002308 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935593002309 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935593002310 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935593002311 co-chaperone HscB; Provisional; Region: hscB; PRK03578 935593002312 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935593002313 HSP70 interaction site [polypeptide binding]; other site 935593002314 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 935593002315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 935593002316 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 935593002317 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 935593002318 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 935593002319 trimerization site [polypeptide binding]; other site 935593002320 active site 935593002321 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 935593002322 cysteine desulfurase; Provisional; Region: PRK14012 935593002323 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 935593002324 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 935593002325 catalytic residue [active] 935593002326 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 935593002327 Rrf2 family protein; Region: rrf2_super; TIGR00738 935593002328 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 935593002329 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935593002330 phosphate binding site [ion binding]; other site 935593002331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 935593002332 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 935593002333 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 935593002334 RNA binding site [nucleotide binding]; other site 935593002335 active site 935593002336 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 935593002337 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 935593002338 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 935593002339 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 935593002340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593002341 Walker A motif; other site 935593002342 ATP binding site [chemical binding]; other site 935593002343 Walker B motif; other site 935593002344 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 935593002345 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 935593002346 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935593002347 inhibitor-cofactor binding pocket; inhibition site 935593002348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593002349 catalytic residue [active] 935593002350 helicase 45; Provisional; Region: PTZ00424 935593002351 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 935593002352 ATP binding site [chemical binding]; other site 935593002353 Mg++ binding site [ion binding]; other site 935593002354 motif III; other site 935593002355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935593002356 nucleotide binding region [chemical binding]; other site 935593002357 ATP-binding site [chemical binding]; other site 935593002358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593002359 S-adenosylmethionine binding site [chemical binding]; other site 935593002360 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 935593002361 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935593002362 catalytic residues [active] 935593002363 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 935593002364 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 935593002365 homodimer interface [polypeptide binding]; other site 935593002366 NAD binding pocket [chemical binding]; other site 935593002367 ATP binding pocket [chemical binding]; other site 935593002368 Mg binding site [ion binding]; other site 935593002369 active-site loop [active] 935593002370 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 935593002371 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 935593002372 generic binding surface II; other site 935593002373 generic binding surface I; other site 935593002374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935593002375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935593002376 putative substrate translocation pore; other site 935593002377 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 935593002378 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935593002379 RNA binding surface [nucleotide binding]; other site 935593002380 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 935593002381 probable active site [active] 935593002382 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 935593002383 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 935593002384 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 935593002385 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 935593002386 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935593002387 catalytic loop [active] 935593002388 iron binding site [ion binding]; other site 935593002389 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 935593002390 FAD binding pocket [chemical binding]; other site 935593002391 FAD binding motif [chemical binding]; other site 935593002392 phosphate binding motif [ion binding]; other site 935593002393 beta-alpha-beta structure motif; other site 935593002394 NAD binding pocket [chemical binding]; other site 935593002395 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 935593002396 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 935593002397 GatB domain; Region: GatB_Yqey; smart00845 935593002398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 935593002399 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 935593002400 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 935593002401 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 935593002402 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 935593002403 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 935593002404 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 935593002405 NAD(P) binding site [chemical binding]; other site 935593002406 catalytic residues [active] 935593002407 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 935593002408 16S rRNA methyltransferase B; Provisional; Region: PRK10901 935593002409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593002410 S-adenosylmethionine binding site [chemical binding]; other site 935593002411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3782 935593002412 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 935593002413 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 935593002414 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935593002415 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 935593002416 active site 935593002417 dimerization interface [polypeptide binding]; other site 935593002418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 935593002419 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 935593002420 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935593002421 E3 interaction surface; other site 935593002422 lipoyl attachment site [posttranslational modification]; other site 935593002423 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 935593002424 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 935593002425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935593002426 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935593002427 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 935593002428 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935593002429 E3 interaction surface; other site 935593002430 lipoyl attachment site [posttranslational modification]; other site 935593002431 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935593002432 E3 interaction surface; other site 935593002433 lipoyl attachment site [posttranslational modification]; other site 935593002434 e3 binding domain; Region: E3_binding; pfam02817 935593002435 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 935593002436 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 935593002437 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 935593002438 dimer interface [polypeptide binding]; other site 935593002439 TPP-binding site [chemical binding]; other site 935593002440 prolyl-tRNA synthetase; Provisional; Region: PRK09194 935593002441 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 935593002442 dimer interface [polypeptide binding]; other site 935593002443 motif 1; other site 935593002444 active site 935593002445 motif 2; other site 935593002446 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 935593002447 putative deacylase active site [active] 935593002448 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935593002449 active site 935593002450 motif 3; other site 935593002451 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 935593002452 anticodon binding site; other site 935593002453 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 935593002454 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 935593002455 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 935593002456 Putative transcriptional regulator [Transcription]; Region: COG1678 935593002457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 935593002458 CreA protein; Region: CreA; pfam05981 935593002459 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 935593002460 Peptidase family M23; Region: Peptidase_M23; pfam01551 935593002461 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 935593002462 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 935593002463 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 935593002464 protein binding site [polypeptide binding]; other site 935593002465 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 935593002466 Catalytic dyad [active] 935593002467 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 935593002468 excinuclease ABC subunit B; Provisional; Region: PRK05298 935593002469 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935593002470 ATP-binding site [chemical binding]; other site 935593002471 ATP binding site [chemical binding]; other site 935593002472 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935593002473 nucleotide binding region [chemical binding]; other site 935593002474 ATP-binding site [chemical binding]; other site 935593002475 Ultra-violet resistance protein B; Region: UvrB; pfam12344 935593002476 UvrB/uvrC motif; Region: UVR; pfam02151 935593002477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593002478 S-adenosylmethionine binding site [chemical binding]; other site 935593002479 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935593002480 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935593002481 Sel1-like repeats; Region: SEL1; smart00671 935593002482 Sel1-like repeats; Region: SEL1; smart00671 935593002483 Sel1-like repeats; Region: SEL1; smart00671 935593002484 Sel1-like repeats; Region: SEL1; smart00671 935593002485 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 935593002486 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 935593002487 GIY-YIG motif/motif A; other site 935593002488 active site 935593002489 catalytic site [active] 935593002490 putative DNA binding site [nucleotide binding]; other site 935593002491 metal binding site [ion binding]; metal-binding site 935593002492 UvrB/uvrC motif; Region: UVR; pfam02151 935593002493 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 935593002494 Helix-hairpin-helix motif; Region: HHH; pfam00633 935593002495 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 935593002496 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935593002497 metal-binding site [ion binding] 935593002498 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 935593002499 Soluble P-type ATPase [General function prediction only]; Region: COG4087 935593002500 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 935593002501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935593002502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935593002503 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 935593002504 Primosomal replication protein N [DNA replication, recombination, and repair]; Region: PriB; COG2965 935593002505 generic binding surface I; other site 935593002506 generic binding surface II; other site 935593002507 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 935593002508 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 935593002509 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 935593002510 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 935593002511 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 935593002512 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 935593002513 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 935593002514 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 935593002515 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 935593002516 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 935593002517 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 935593002518 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 935593002519 trigger factor; Provisional; Region: tig; PRK01490 935593002520 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935593002521 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 935593002522 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 935593002523 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 935593002524 oligomer interface [polypeptide binding]; other site 935593002525 active site residues [active] 935593002526 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 935593002527 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 935593002528 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 935593002529 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 935593002530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935593002531 binding surface 935593002532 TPR motif; other site 935593002533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935593002534 TPR motif; other site 935593002535 binding surface 935593002536 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 935593002537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935593002538 FeS/SAM binding site; other site 935593002539 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 935593002540 active site 935593002541 multimer interface [polypeptide binding]; other site 935593002542 Predicted ATPase [General function prediction only]; Region: COG1485 935593002543 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 935593002544 S-formylglutathione hydrolase; Region: PLN02442 935593002545 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 935593002546 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 935593002547 substrate binding site [chemical binding]; other site 935593002548 catalytic Zn binding site [ion binding]; other site 935593002549 NAD binding site [chemical binding]; other site 935593002550 structural Zn binding site [ion binding]; other site 935593002551 dimer interface [polypeptide binding]; other site 935593002552 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 935593002553 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 935593002554 DNA binding residues [nucleotide binding] 935593002555 putative dimer interface [polypeptide binding]; other site 935593002556 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 935593002557 IHF dimer interface [polypeptide binding]; other site 935593002558 IHF - DNA interface [nucleotide binding]; other site 935593002559 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 935593002560 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 935593002561 RNA binding site [nucleotide binding]; other site 935593002562 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 935593002563 RNA binding site [nucleotide binding]; other site 935593002564 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 935593002565 RNA binding site [nucleotide binding]; other site 935593002566 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 935593002567 RNA binding site [nucleotide binding]; other site 935593002568 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 935593002569 RNA binding site [nucleotide binding]; other site 935593002570 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 935593002571 RNA binding site [nucleotide binding]; other site 935593002572 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 935593002573 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 935593002574 CMP-binding site; other site 935593002575 The sites determining sugar specificity; other site 935593002576 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 935593002577 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 935593002578 RNA binding surface [nucleotide binding]; other site 935593002579 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 935593002580 active site 935593002581 uracil binding [chemical binding]; other site 935593002582 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 935593002583 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935593002584 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935593002585 catalytic residue [active] 935593002586 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935593002587 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 935593002588 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935593002589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 935593002590 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 935593002591 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 935593002592 DNA binding site [nucleotide binding] 935593002593 catalytic residue [active] 935593002594 H2TH interface [polypeptide binding]; other site 935593002595 putative catalytic residues [active] 935593002596 turnover-facilitating residue; other site 935593002597 intercalation triad [nucleotide binding]; other site 935593002598 8OG recognition residue [nucleotide binding]; other site 935593002599 putative reading head residues; other site 935593002600 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 935593002601 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 935593002602 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 935593002603 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 935593002604 putative acyl-acceptor binding pocket; other site 935593002605 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 935593002606 ATP cone domain; Region: ATP-cone; pfam03477 935593002607 Class I ribonucleotide reductase; Region: RNR_I; cd01679 935593002608 active site 935593002609 dimer interface [polypeptide binding]; other site 935593002610 catalytic residues [active] 935593002611 effector binding site; other site 935593002612 R2 peptide binding site; other site 935593002613 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935593002614 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 935593002615 cofactor binding site; other site 935593002616 DNA binding site [nucleotide binding] 935593002617 substrate interaction site [chemical binding]; other site 935593002618 N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016 935593002619 DNA binding site [nucleotide binding] 935593002620 EcoRII C terminal; Region: EcoRII-C; pfam09019 935593002621 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 935593002622 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 935593002623 dimer interface [polypeptide binding]; other site 935593002624 putative radical transfer pathway; other site 935593002625 diiron center [ion binding]; other site 935593002626 tyrosyl radical; other site 935593002627 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 935593002628 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935593002629 catalytic loop [active] 935593002630 iron binding site [ion binding]; other site 935593002631 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 935593002632 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 935593002633 enolase; Provisional; Region: eno; PRK00077 935593002634 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 935593002635 dimer interface [polypeptide binding]; other site 935593002636 metal binding site [ion binding]; metal-binding site 935593002637 substrate binding pocket [chemical binding]; other site 935593002638 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 935593002639 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 935593002640 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 935593002641 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 935593002642 tetramerization interface [polypeptide binding]; other site 935593002643 active site 935593002644 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 935593002645 DEAD-like helicases superfamily; Region: DEXDc; smart00487 935593002646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935593002647 ATP binding site [chemical binding]; other site 935593002648 putative Mg++ binding site [ion binding]; other site 935593002649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935593002650 nucleotide binding region [chemical binding]; other site 935593002651 ATP-binding site [chemical binding]; other site 935593002652 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 935593002653 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 935593002654 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 935593002655 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 935593002656 active site 935593002657 Transglycosylase SLT domain; Region: SLT_2; pfam13406 935593002658 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935593002659 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935593002660 Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389 935593002661 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 935593002662 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 935593002663 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 935593002664 acyl-activating enzyme (AAE) consensus motif; other site 935593002665 putative AMP binding site [chemical binding]; other site 935593002666 putative active site [active] 935593002667 putative CoA binding site [chemical binding]; other site 935593002668 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 935593002669 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 935593002670 active site 935593002671 oxyanion hole [active] 935593002672 catalytic triad [active] 935593002673 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 935593002674 active site 935593002675 catalytic triad [active] 935593002676 oxyanion hole [active] 935593002677 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 935593002678 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935593002679 metal-binding site [ion binding] 935593002680 Methyltransferase domain; Region: Methyltransf_31; pfam13847 935593002681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593002682 S-adenosylmethionine binding site [chemical binding]; other site 935593002683 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 935593002684 glycerate kinase; Region: TIGR00045 935593002685 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 935593002686 Low molecular weight phosphatase family; Region: LMWPc; cd00115 935593002687 active site 935593002688 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 935593002689 metal binding site 2 [ion binding]; metal-binding site 935593002690 putative DNA binding helix; other site 935593002691 metal binding site 1 [ion binding]; metal-binding site 935593002692 dimer interface [polypeptide binding]; other site 935593002693 structural Zn2+ binding site [ion binding]; other site 935593002694 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 935593002695 active site 935593002696 NTP binding site [chemical binding]; other site 935593002697 metal binding triad [ion binding]; metal-binding site 935593002698 antibiotic binding site [chemical binding]; other site 935593002699 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 935593002700 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 935593002701 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 935593002702 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 935593002703 substrate binding site [chemical binding]; other site 935593002704 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 935593002705 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 935593002706 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593002707 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593002708 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593002709 Homeodomain-like domain; Region: HTH_32; pfam13565 935593002710 Integrase core domain; Region: rve; pfam00665 935593002711 recombination factor protein RarA; Reviewed; Region: PRK13342 935593002712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593002713 Walker A motif; other site 935593002714 ATP binding site [chemical binding]; other site 935593002715 Walker B motif; other site 935593002716 arginine finger; other site 935593002717 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 935593002718 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 935593002719 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 935593002720 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 935593002721 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 935593002722 dimerization interface [polypeptide binding]; other site 935593002723 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 935593002724 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 935593002725 active site 935593002726 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 935593002727 dimerization interface [polypeptide binding]; other site 935593002728 active site 935593002729 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 935593002730 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 935593002731 dimerization interface [polypeptide binding]; other site 935593002732 putative ATP binding site [chemical binding]; other site 935593002733 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593002734 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593002735 Homeodomain-like domain; Region: HTH_32; pfam13565 935593002736 Integrase core domain; Region: rve; pfam00665 935593002737 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 935593002738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935593002739 active site 935593002740 phosphorylation site [posttranslational modification] 935593002741 intermolecular recognition site; other site 935593002742 dimerization interface [polypeptide binding]; other site 935593002743 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 935593002744 DNA binding residues [nucleotide binding] 935593002745 dimerization interface [polypeptide binding]; other site 935593002746 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 935593002747 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 935593002748 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935593002749 dimerization interface [polypeptide binding]; other site 935593002750 GAF domain; Region: GAF_3; pfam13492 935593002751 Histidine kinase; Region: HisKA_3; pfam07730 935593002752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935593002753 ATP binding site [chemical binding]; other site 935593002754 Mg2+ binding site [ion binding]; other site 935593002755 G-X-G motif; other site 935593002756 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 935593002757 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 935593002758 GTP binding site; other site 935593002759 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 935593002760 Lumazine binding domain; Region: Lum_binding; pfam00677 935593002761 Lumazine binding domain; Region: Lum_binding; pfam00677 935593002762 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 935593002763 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 935593002764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593002765 Walker A motif; other site 935593002766 ATP binding site [chemical binding]; other site 935593002767 Walker B motif; other site 935593002768 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678 935593002769 dimer interface [polypeptide binding]; other site 935593002770 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 935593002771 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 935593002772 substrate binding site [chemical binding]; other site 935593002773 hexamer interface [polypeptide binding]; other site 935593002774 metal binding site [ion binding]; metal-binding site 935593002775 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 935593002776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593002777 Walker A motif; other site 935593002778 ATP binding site [chemical binding]; other site 935593002779 Walker B motif; other site 935593002780 arginine finger; other site 935593002781 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 935593002782 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 935593002783 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 935593002784 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 935593002785 active site 935593002786 NTP binding site [chemical binding]; other site 935593002787 metal binding triad [ion binding]; metal-binding site 935593002788 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 935593002789 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935593002790 Zn2+ binding site [ion binding]; other site 935593002791 Mg2+ binding site [ion binding]; other site 935593002792 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 935593002793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935593002794 Walker A/P-loop; other site 935593002795 ATP binding site [chemical binding]; other site 935593002796 ABC transporter signature motif; other site 935593002797 Walker B; other site 935593002798 D-loop; other site 935593002799 H-loop/switch region; other site 935593002800 ABC transporter; Region: ABC_tran_2; pfam12848 935593002801 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935593002802 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 935593002803 ArsC family; Region: ArsC; pfam03960 935593002804 putative catalytic residues [active] 935593002805 SurA N-terminal domain; Region: SurA_N_3; cl07813 935593002806 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 935593002807 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 935593002808 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 935593002809 RecR protein; Region: RecR; pfam02132 935593002810 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 935593002811 putative active site [active] 935593002812 putative metal-binding site [ion binding]; other site 935593002813 tetramer interface [polypeptide binding]; other site 935593002814 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 935593002815 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 935593002816 FtsX-like permease family; Region: FtsX; pfam02687 935593002817 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 935593002818 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 935593002819 Walker A/P-loop; other site 935593002820 ATP binding site [chemical binding]; other site 935593002821 Q-loop/lid; other site 935593002822 ABC transporter signature motif; other site 935593002823 Walker B; other site 935593002824 D-loop; other site 935593002825 H-loop/switch region; other site 935593002826 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 935593002827 AAA domain; Region: AAA_30; pfam13604 935593002828 Family description; Region: UvrD_C_2; pfam13538 935593002829 Methyltransferase domain; Region: Methyltransf_23; pfam13489 935593002830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593002831 S-adenosylmethionine binding site [chemical binding]; other site 935593002832 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 935593002833 Found in ATP-dependent protease La (LON); Region: LON; smart00464 935593002834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593002835 Walker A motif; other site 935593002836 ATP binding site [chemical binding]; other site 935593002837 Walker B motif; other site 935593002838 arginine finger; other site 935593002839 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 935593002840 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 935593002841 IHF dimer interface [polypeptide binding]; other site 935593002842 IHF - DNA interface [nucleotide binding]; other site 935593002843 homoserine dehydrogenase; Provisional; Region: PRK06349 935593002844 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 935593002845 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 935593002846 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 935593002847 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 935593002848 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 935593002849 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935593002850 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935593002851 ABC transporter; Region: ABC_tran_2; pfam12848 935593002852 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935593002853 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 935593002854 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 935593002855 ligand binding site [chemical binding]; other site 935593002856 active site 935593002857 UGI interface [polypeptide binding]; other site 935593002858 catalytic site [active] 935593002859 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 935593002860 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 935593002861 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 935593002862 Domain of unknown function DUF20; Region: UPF0118; pfam01594 935593002863 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 935593002864 Uncharacterized conserved protein [Function unknown]; Region: COG2921 935593002865 lipoate-protein ligase B; Provisional; Region: PRK14342 935593002866 lipoyl synthase; Provisional; Region: PRK05481 935593002867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935593002868 FeS/SAM binding site; other site 935593002869 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 935593002870 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935593002871 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593002872 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935593002873 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935593002874 ACP:hemolysin acyltransferase (hemolysin-activating protein) [Posttranslational modification, protein turnover, chaperones]; Region: HlyC; COG2994 935593002875 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 935593002876 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 935593002877 heme binding site [chemical binding]; other site 935593002878 ferroxidase pore; other site 935593002879 ferroxidase diiron center [ion binding]; other site 935593002880 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 935593002881 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 935593002882 heme binding site [chemical binding]; other site 935593002883 ferroxidase pore; other site 935593002884 ferroxidase diiron center [ion binding]; other site 935593002885 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 935593002886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935593002887 non-specific DNA binding site [nucleotide binding]; other site 935593002888 salt bridge; other site 935593002889 sequence-specific DNA binding site [nucleotide binding]; other site 935593002890 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 935593002891 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935593002892 metal binding triad; other site 935593002893 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 935593002894 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935593002895 Zn2+ binding site [ion binding]; other site 935593002896 Mg2+ binding site [ion binding]; other site 935593002897 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 935593002898 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 935593002899 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 935593002900 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935593002901 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 935593002902 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 935593002903 active site 935593002904 ribonuclease R; Region: RNase_R; TIGR02063 935593002905 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 935593002906 RNB domain; Region: RNB; pfam00773 935593002907 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 935593002908 RNA binding site [nucleotide binding]; other site 935593002909 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 935593002910 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 935593002911 G1 box; other site 935593002912 putative GEF interaction site [polypeptide binding]; other site 935593002913 GTP/Mg2+ binding site [chemical binding]; other site 935593002914 Switch I region; other site 935593002915 G2 box; other site 935593002916 G3 box; other site 935593002917 Switch II region; other site 935593002918 G4 box; other site 935593002919 G5 box; other site 935593002920 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 935593002921 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 935593002922 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 935593002923 putative substrate binding site [chemical binding]; other site 935593002924 putative ATP binding site [chemical binding]; other site 935593002925 Cytochrome b [Energy production and conversion]; Region: COG3658 935593002926 siroheme synthase; Provisional; Region: cysG; PRK10637 935593002927 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 935593002928 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 935593002929 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 935593002930 active site 935593002931 SAM binding site [chemical binding]; other site 935593002932 homodimer interface [polypeptide binding]; other site 935593002933 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 935593002934 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 935593002935 Active Sites [active] 935593002936 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 935593002937 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 935593002938 Active Sites [active] 935593002939 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 935593002940 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 935593002941 CysD dimerization site [polypeptide binding]; other site 935593002942 G1 box; other site 935593002943 putative GEF interaction site [polypeptide binding]; other site 935593002944 GTP/Mg2+ binding site [chemical binding]; other site 935593002945 Switch I region; other site 935593002946 G2 box; other site 935593002947 G3 box; other site 935593002948 Switch II region; other site 935593002949 G4 box; other site 935593002950 G5 box; other site 935593002951 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 935593002952 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 935593002953 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 935593002954 Flavodoxin; Region: Flavodoxin_1; pfam00258 935593002955 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 935593002956 FAD binding pocket [chemical binding]; other site 935593002957 FAD binding motif [chemical binding]; other site 935593002958 catalytic residues [active] 935593002959 NAD binding pocket [chemical binding]; other site 935593002960 phosphate binding motif [ion binding]; other site 935593002961 beta-alpha-beta structure motif; other site 935593002962 sulfite reductase (NADPH) hemoprotein, beta-component; Region: CysI; TIGR02041 935593002963 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 935593002964 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 935593002965 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 935593002966 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 935593002967 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 935593002968 biotin synthase; Region: bioB; TIGR00433 935593002969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935593002970 FeS/SAM binding site; other site 935593002971 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 935593002972 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 935593002973 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935593002974 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935593002975 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935593002976 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 935593002977 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 935593002978 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 935593002979 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 935593002980 Ligand Binding Site [chemical binding]; other site 935593002981 TilS substrate binding domain; Region: TilS; pfam09179 935593002982 tRNA(Ile)-lysidine synthetase, C-terminal domain; Region: lysidine_TilS_C; TIGR02433 935593002983 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 935593002984 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 935593002985 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935593002986 RNA binding surface [nucleotide binding]; other site 935593002987 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 935593002988 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 935593002989 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935593002990 catalytic loop [active] 935593002991 iron binding site [ion binding]; other site 935593002992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 935593002993 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 935593002994 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 935593002995 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 935593002996 T5orf172 domain; Region: T5orf172; pfam10544 935593002997 chaperone protein HscA; Provisional; Region: hscA; PRK05183 935593002998 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 935593002999 nucleotide binding site [chemical binding]; other site 935593003000 putative NEF/HSP70 interaction site [polypeptide binding]; other site 935593003001 SBD interface [polypeptide binding]; other site 935593003002 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 935593003003 active site lid residues [active] 935593003004 substrate binding pocket [chemical binding]; other site 935593003005 catalytic residues [active] 935593003006 substrate-Mg2+ binding site; other site 935593003007 aspartate-rich region 1; other site 935593003008 aspartate-rich region 2; other site 935593003009 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 935593003010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 935593003011 short chain dehydrogenase; Provisional; Region: PRK08703 935593003012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935593003013 NAD(P) binding site [chemical binding]; other site 935593003014 active site 935593003015 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 935593003016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 935593003017 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 935593003018 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 935593003019 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 935593003020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 935593003021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 935593003022 Phage Tail Collar Domain; Region: Collar; pfam07484 935593003023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 935593003024 Mu-like prophage protein gp46 [Function unknown]; Region: COG4381 935593003025 Mu-like prophage protein gp45 [Function unknown]; Region: COG4384 935593003026 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 935593003027 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 935593003028 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 935593003029 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 935593003030 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 935593003031 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 935593003032 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 935593003033 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 935593003034 Mu-like prophage protein gp37 [General function prediction only]; Region: COG5003 935593003035 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 935593003036 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 935593003037 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593003038 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593003039 Homeodomain-like domain; Region: HTH_32; pfam13565 935593003040 Integrase core domain; Region: rve; pfam00665 935593003041 Mu-like prophage I protein [General function prediction only]; Region: COG4388 935593003042 Mu-like prophage protein gpG [General function prediction only]; Region: COG5005 935593003043 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 935593003044 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 935593003045 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 935593003046 Protein of unknown function (DUF935); Region: DUF935; pfam06074 935593003047 phage uncharacterized protein (putative large terminase), C-terminal domain; Region: psiM2_ORF9; TIGR01630 935593003048 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 935593003049 Uncharacterized conserved protein [Function unknown]; Region: COG3422 935593003050 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 935593003051 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 935593003052 active site 935593003053 metal binding site [ion binding]; metal-binding site 935593003054 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 935593003055 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 935593003056 AAA domain; Region: AAA_22; pfam13401 935593003057 Walker A motif; other site 935593003058 ATP binding site [chemical binding]; other site 935593003059 Mor transcription activator family; Region: Mor; cl02360 935593003060 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 935593003061 Integrase core domain; Region: rve; pfam00665 935593003062 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 935593003063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935593003064 non-specific DNA binding site [nucleotide binding]; other site 935593003065 salt bridge; other site 935593003066 sequence-specific DNA binding site [nucleotide binding]; other site 935593003067 ORF6C domain; Region: ORF6C; pfam10552 935593003068 Predicted transcriptional regulator [Transcription]; Region: COG2932 935593003069 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935593003070 Catalytic site [active] 935593003071 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 935593003072 ABC transporter; Region: ABC_tran; pfam00005 935593003073 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 935593003074 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 935593003075 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 935593003076 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 935593003077 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 935593003078 feedback inhibition sensing region; other site 935593003079 homohexameric interface [polypeptide binding]; other site 935593003080 nucleotide binding site [chemical binding]; other site 935593003081 N-acetyl-L-glutamate binding site [chemical binding]; other site 935593003082 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 935593003083 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 935593003084 putative active site [active] 935593003085 Zn binding site [ion binding]; other site 935593003086 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 935593003087 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 935593003088 yecA family protein; Region: ygfB_yecA; TIGR02292 935593003089 SEC-C motif; Region: SEC-C; pfam02810 935593003090 2-isopropylmalate synthase; Validated; Region: PRK00915 935593003091 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 935593003092 active site 935593003093 catalytic residues [active] 935593003094 metal binding site [ion binding]; metal-binding site 935593003095 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 935593003096 glutamate 5-kinase; Region: proB; TIGR01027 935593003097 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 935593003098 nucleotide binding site [chemical binding]; other site 935593003099 homotetrameric interface [polypeptide binding]; other site 935593003100 putative phosphate binding site [ion binding]; other site 935593003101 putative allosteric binding site; other site 935593003102 PUA domain; Region: PUA; pfam01472 935593003103 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 935593003104 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 935593003105 putative catalytic cysteine [active] 935593003106 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 935593003107 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 935593003108 Predicted membrane protein [Function unknown]; Region: COG3235 935593003109 camphor resistance protein CrcB; Provisional; Region: PRK14230 935593003110 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 935593003111 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 935593003112 dimer interface [polypeptide binding]; other site 935593003113 ADP-ribose binding site [chemical binding]; other site 935593003114 active site 935593003115 nudix motif; other site 935593003116 metal binding site [ion binding]; metal-binding site 935593003117 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 935593003118 active site 935593003119 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 935593003120 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 935593003121 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 935593003122 AMP binding site [chemical binding]; other site 935593003123 metal binding site [ion binding]; metal-binding site 935593003124 active site 935593003125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 935593003126 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 935593003127 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 935593003128 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 935593003129 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 935593003130 dimer interface [polypeptide binding]; other site 935593003131 active site 935593003132 glycine-pyridoxal phosphate binding site [chemical binding]; other site 935593003133 folate binding site [chemical binding]; other site 935593003134 Transposase domain (DUF772); Region: DUF772; pfam05598 935593003135 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593003136 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935593003137 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935593003138 Outer membrane protein OpcA; Region: OpcA; pfam07239 935593003139 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 935593003140 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 935593003141 ABC transporter ATPase component; Reviewed; Region: PRK11147 935593003142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935593003143 Walker A/P-loop; other site 935593003144 ATP binding site [chemical binding]; other site 935593003145 Q-loop/lid; other site 935593003146 ABC transporter signature motif; other site 935593003147 Walker B; other site 935593003148 D-loop; other site 935593003149 H-loop/switch region; other site 935593003150 ABC transporter; Region: ABC_tran_2; pfam12848 935593003151 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935593003152 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593003153 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593003154 Homeodomain-like domain; Region: HTH_32; pfam13565 935593003155 Integrase core domain; Region: rve; pfam00665 935593003156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935593003157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935593003158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 935593003159 dimerization interface [polypeptide binding]; other site 935593003160 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 935593003161 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 935593003162 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 935593003163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593003164 catalytic residue [active] 935593003165 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 935593003166 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 935593003167 FAD binding pocket [chemical binding]; other site 935593003168 FAD binding motif [chemical binding]; other site 935593003169 phosphate binding motif [ion binding]; other site 935593003170 beta-alpha-beta structure motif; other site 935593003171 NAD binding pocket [chemical binding]; other site 935593003172 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 935593003173 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 935593003174 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935593003175 metal-binding site [ion binding] 935593003176 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 935593003177 Soluble P-type ATPase [General function prediction only]; Region: COG4087 935593003178 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 935593003179 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 935593003180 HflX GTPase family; Region: HflX; cd01878 935593003181 G1 box; other site 935593003182 GTP/Mg2+ binding site [chemical binding]; other site 935593003183 Switch I region; other site 935593003184 G2 box; other site 935593003185 G3 box; other site 935593003186 Switch II region; other site 935593003187 G4 box; other site 935593003188 G5 box; other site 935593003189 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 935593003190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 935593003191 hypothetical protein; Reviewed; Region: PRK00024 935593003192 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 935593003193 MPN+ (JAMM) motif; other site 935593003194 Zinc-binding site [ion binding]; other site 935593003195 Glutamate-cysteine ligase; Region: GshA; pfam08886 935593003196 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 935593003197 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 935593003198 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 935593003199 substrate binding site [chemical binding]; other site 935593003200 ligand binding site [chemical binding]; other site 935593003201 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 935593003202 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 935593003203 substrate binding site [chemical binding]; other site 935593003204 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 935593003205 tartrate dehydrogenase; Region: TTC; TIGR02089 935593003206 Uncharacterized conserved protein [Function unknown]; Region: COG2353 935593003207 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 935593003208 Aspartase; Region: Aspartase; cd01357 935593003209 active sites [active] 935593003210 tetramer interface [polypeptide binding]; other site 935593003211 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 935593003212 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935593003213 HSP70 interaction site [polypeptide binding]; other site 935593003214 Predicted membrane protein [Function unknown]; Region: COG3671 935593003215 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 935593003216 putative deacylase active site [active] 935593003217 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 935593003218 homotrimer interaction site [polypeptide binding]; other site 935593003219 putative active site [active] 935593003220 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 935593003221 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 935593003222 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 935593003223 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 935593003224 Ligand Binding Site [chemical binding]; other site 935593003225 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593003226 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593003227 Homeodomain-like domain; Region: HTH_32; pfam13565 935593003228 Integrase core domain; Region: rve; pfam00665 935593003229 anthranilate synthase component I; Provisional; Region: PRK13565 935593003230 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 935593003231 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 935593003232 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 935593003233 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 935593003234 ATP-grasp domain; Region: ATP-grasp; pfam02222 935593003235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 935593003236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935593003237 Coenzyme A binding pocket [chemical binding]; other site 935593003238 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 935593003239 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 935593003240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 935593003241 Smr domain; Region: Smr; pfam01713 935593003242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 935593003243 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 935593003244 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 935593003245 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 935593003246 Predicted transcriptional regulator [Transcription]; Region: COG2932 935593003247 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935593003248 Catalytic site [active] 935593003249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 935593003250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935593003251 non-specific DNA binding site [nucleotide binding]; other site 935593003252 salt bridge; other site 935593003253 sequence-specific DNA binding site [nucleotide binding]; other site 935593003254 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 935593003255 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 935593003256 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 935593003257 Transposase domain (DUF772); Region: DUF772; pfam05598 935593003258 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593003259 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593003260 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 935593003261 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 935593003262 FMN binding site [chemical binding]; other site 935593003263 active site 935593003264 catalytic residues [active] 935593003265 substrate binding site [chemical binding]; other site 935593003266 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 935593003267 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 935593003268 FAD binding domain; Region: FAD_binding_4; pfam01565 935593003269 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 935593003270 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 935593003271 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 935593003272 Cysteine-rich domain; Region: CCG; pfam02754 935593003273 Cysteine-rich domain; Region: CCG; pfam02754 935593003274 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 935593003275 D-lactate dehydrogenase; Provisional; Region: PRK11183 935593003276 FAD binding domain; Region: FAD_binding_4; pfam01565 935593003277 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 935593003278 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 935593003279 Uncharacterized conserved protein [Function unknown]; Region: COG2128 935593003280 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 935593003281 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 935593003282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 935593003283 active site 935593003284 Rubredoxin [Energy production and conversion]; Region: COG1773 935593003285 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 935593003286 iron binding site [ion binding]; other site 935593003287 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 935593003288 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 935593003289 YadA-like C-terminal region; Region: YadA; pfam03895 935593003290 Transposase domain (DUF772); Region: DUF772; pfam05598 935593003291 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593003292 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935593003293 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 935593003294 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 935593003295 active site 935593003296 metal binding site [ion binding]; metal-binding site 935593003297 Mor transcription activator family; Region: Mor; cl02360 935593003298 Mu-like prophage protein gp16 [Function unknown]; Region: COG4382 935593003299 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 935593003300 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 935593003301 purine monophosphate binding site [chemical binding]; other site 935593003302 dimer interface [polypeptide binding]; other site 935593003303 putative catalytic residues [active] 935593003304 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 935593003305 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 935593003306 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 935593003307 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 935593003308 putative ion selectivity filter; other site 935593003309 putative pore gating glutamate residue; other site 935593003310 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 935593003311 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 935593003312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935593003313 motif II; other site 935593003314 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 935593003315 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 935593003316 ligand binding site [chemical binding]; other site 935593003317 homodimer interface [polypeptide binding]; other site 935593003318 NAD(P) binding site [chemical binding]; other site 935593003319 trimer interface B [polypeptide binding]; other site 935593003320 trimer interface A [polypeptide binding]; other site 935593003321 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 935593003322 Predicted membrane protein [Function unknown]; Region: COG3686 935593003323 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 935593003324 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 935593003325 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 935593003326 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935593003327 Protein of unknown function (DUF1132); Region: DUF1132; pfam06575 935593003328 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935593003329 Replication initiation factor; Region: Rep_trans; pfam02486 935593003330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935593003331 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 935593003332 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 935593003333 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 935593003334 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 935593003335 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 935593003336 glutamine binding [chemical binding]; other site 935593003337 catalytic triad [active] 935593003338 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 935593003339 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 935593003340 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935593003341 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 935593003342 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 935593003343 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 935593003344 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 935593003345 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 935593003346 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 935593003347 CoA binding domain; Region: CoA_binding; smart00881 935593003348 CoA-ligase; Region: Ligase_CoA; pfam00549 935593003349 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 935593003350 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 935593003351 CoA-ligase; Region: Ligase_CoA; pfam00549 935593003352 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 935593003353 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 935593003354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935593003355 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935593003356 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 935593003357 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935593003358 E3 interaction surface; other site 935593003359 lipoyl attachment site [posttranslational modification]; other site 935593003360 e3 binding domain; Region: E3_binding; pfam02817 935593003361 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 935593003362 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 935593003363 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 935593003364 TPP-binding site [chemical binding]; other site 935593003365 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 935593003366 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 935593003367 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 935593003368 dimer interface [polypeptide binding]; other site 935593003369 active site 935593003370 citrylCoA binding site [chemical binding]; other site 935593003371 NADH binding [chemical binding]; other site 935593003372 cationic pore residues; other site 935593003373 oxalacetate/citrate binding site [chemical binding]; other site 935593003374 coenzyme A binding site [chemical binding]; other site 935593003375 catalytic triad [active] 935593003376 Uncharacterized conserved protein [Function unknown]; Region: COG2938 935593003377 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 935593003378 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 935593003379 succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; Region: sdhA_forward; TIGR01816 935593003380 L-aspartate oxidase; Provisional; Region: PRK06175 935593003381 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 935593003382 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 935593003383 SdhC subunit interface [polypeptide binding]; other site 935593003384 proximal heme binding site [chemical binding]; other site 935593003385 cardiolipin binding site; other site 935593003386 Iron-sulfur protein interface; other site 935593003387 proximal quinone binding site [chemical binding]; other site 935593003388 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 935593003389 Iron-sulfur protein interface; other site 935593003390 proximal quinone binding site [chemical binding]; other site 935593003391 SdhD (CybS) interface [polypeptide binding]; other site 935593003392 proximal heme binding site [chemical binding]; other site 935593003393 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 935593003394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935593003395 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935593003396 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 935593003397 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 935593003398 catalytic triad [active] 935593003399 dimer interface [polypeptide binding]; other site 935593003400 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 935593003401 GSH binding site [chemical binding]; other site 935593003402 catalytic residues [active] 935593003403 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 935593003404 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 935593003405 THF binding site; other site 935593003406 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 935593003407 substrate binding site [chemical binding]; other site 935593003408 THF binding site; other site 935593003409 zinc-binding site [ion binding]; other site 935593003410 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 935593003411 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 935593003412 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 935593003413 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 935593003414 Methyltransferase domain; Region: Methyltransf_23; pfam13489 935593003415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593003416 S-adenosylmethionine binding site [chemical binding]; other site 935593003417 elongation factor P; Validated; Region: PRK00529 935593003418 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 935593003419 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 935593003420 RNA binding site [nucleotide binding]; other site 935593003421 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 935593003422 RNA binding site [nucleotide binding]; other site 935593003423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 935593003424 conserved hypothetical protein, PP_1857 family; Region: efp_adjacent_2; TIGR03837 935593003425 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 935593003426 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 935593003427 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 935593003428 nucleoside/Zn binding site; other site 935593003429 dimer interface [polypeptide binding]; other site 935593003430 catalytic motif [active] 935593003431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 935593003432 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 935593003433 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 935593003434 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 935593003435 xanthine permease; Region: pbuX; TIGR03173 935593003436 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 935593003437 dihydrodipicolinate synthase; Region: dapA; TIGR00674 935593003438 dimer interface [polypeptide binding]; other site 935593003439 active site 935593003440 catalytic residue [active] 935593003441 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 935593003442 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 935593003443 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 935593003444 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935593003445 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 935593003446 malonic semialdehyde reductase; Provisional; Region: PRK10538 935593003447 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 935593003448 putative NAD(P) binding site [chemical binding]; other site 935593003449 homotetramer interface [polypeptide binding]; other site 935593003450 homodimer interface [polypeptide binding]; other site 935593003451 active site 935593003452 Cytochrome c556 [Energy production and conversion]; Region: COG3909 935593003453 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 935593003454 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 935593003455 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 935593003456 Transposase domain (DUF772); Region: DUF772; pfam05598 935593003457 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593003458 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593003459 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 935593003460 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Provisional; Region: PRK14844 935593003461 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 935593003462 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 935593003463 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 935593003464 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593003465 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593003466 Homeodomain-like domain; Region: HTH_32; pfam13565 935593003467 Integrase core domain; Region: rve; pfam00665 935593003468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935593003469 non-specific DNA binding site [nucleotide binding]; other site 935593003470 Predicted transcriptional regulator [Transcription]; Region: COG2932 935593003471 salt bridge; other site 935593003472 sequence-specific DNA binding site [nucleotide binding]; other site 935593003473 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935593003474 Catalytic site [active] 935593003475 Uncharacterized conserved protein [Function unknown]; Region: COG5532 935593003476 Predicted helicase [General function prediction only]; Region: COG4889 935593003477 KilA-N domain; Region: KilA-N; pfam04383 935593003478 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 935593003479 active site 935593003480 Int/Topo IB signature motif; other site 935593003481 hypothetical protein; Validated; Region: PRK02101 935593003482 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 935593003483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935593003484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593003485 homodimer interface [polypeptide binding]; other site 935593003486 catalytic residue [active] 935593003487 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 935593003488 trimer interface [polypeptide binding]; other site 935593003489 active site 935593003490 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 935593003491 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935593003492 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 935593003493 Minor type IV pilin, PilX; Region: Pilin_PilX; pfam11530 935593003494 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 935593003495 PilX N-terminal; Region: PilX_N; pfam14341 935593003496 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 935593003497 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 935593003498 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 935593003499 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 935593003500 Type II transport protein GspH; Region: GspH; pfam12019 935593003501 replicative DNA helicase; Region: DnaB; TIGR00665 935593003502 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 935593003503 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 935593003504 Walker A motif; other site 935593003505 ATP binding site [chemical binding]; other site 935593003506 Walker B motif; other site 935593003507 DNA binding loops [nucleotide binding] 935593003508 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 935593003509 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 935593003510 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 935593003511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 935593003512 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 935593003513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935593003514 dimer interface [polypeptide binding]; other site 935593003515 conserved gate region; other site 935593003516 putative PBP binding loops; other site 935593003517 ABC-ATPase subunit interface; other site 935593003518 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 935593003519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935593003520 dimer interface [polypeptide binding]; other site 935593003521 conserved gate region; other site 935593003522 putative PBP binding loops; other site 935593003523 ABC-ATPase subunit interface; other site 935593003524 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 935593003525 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 935593003526 Walker A/P-loop; other site 935593003527 ATP binding site [chemical binding]; other site 935593003528 Q-loop/lid; other site 935593003529 ABC transporter signature motif; other site 935593003530 Walker B; other site 935593003531 D-loop; other site 935593003532 H-loop/switch region; other site 935593003533 threonine dehydratase; Reviewed; Region: PRK09224 935593003534 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 935593003535 tetramer interface [polypeptide binding]; other site 935593003536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593003537 catalytic residue [active] 935593003538 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 935593003539 putative Ile/Val binding site [chemical binding]; other site 935593003540 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 935593003541 putative Ile/Val binding site [chemical binding]; other site 935593003542 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 935593003543 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 935593003544 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 935593003545 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 935593003546 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 935593003547 5S rRNA interface [nucleotide binding]; other site 935593003548 CTC domain interface [polypeptide binding]; other site 935593003549 L16 interface [polypeptide binding]; other site 935593003550 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 935593003551 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 935593003552 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935593003553 active site 935593003554 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 935593003555 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 935593003556 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 935593003557 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 935593003558 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 935593003559 TPR repeat; Region: TPR_11; pfam13414 935593003560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935593003561 binding surface 935593003562 TPR motif; other site 935593003563 pantoate--beta-alanine ligase; Region: panC; TIGR00018 935593003564 Pantoate-beta-alanine ligase; Region: PanC; cd00560 935593003565 active site 935593003566 ATP-binding site [chemical binding]; other site 935593003567 pantoate-binding site; other site 935593003568 HXXH motif; other site 935593003569 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 935593003570 oligomerization interface [polypeptide binding]; other site 935593003571 active site 935593003572 metal binding site [ion binding]; metal-binding site 935593003573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593003574 S-adenosylmethionine binding site [chemical binding]; other site 935593003575 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 935593003576 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 935593003577 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 935593003578 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 935593003579 probable active site [active] 935593003580 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 935593003581 putative active site [active] 935593003582 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 935593003583 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 935593003584 dimer interface [polypeptide binding]; other site 935593003585 motif 1; other site 935593003586 active site 935593003587 motif 2; other site 935593003588 motif 3; other site 935593003589 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 935593003590 anticodon binding site; other site 935593003591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 935593003592 GTP-binding protein Der; Reviewed; Region: PRK00093 935593003593 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 935593003594 G1 box; other site 935593003595 GTP/Mg2+ binding site [chemical binding]; other site 935593003596 Switch I region; other site 935593003597 G2 box; other site 935593003598 Switch II region; other site 935593003599 G3 box; other site 935593003600 G4 box; other site 935593003601 G5 box; other site 935593003602 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 935593003603 G1 box; other site 935593003604 GTP/Mg2+ binding site [chemical binding]; other site 935593003605 Switch I region; other site 935593003606 G2 box; other site 935593003607 G3 box; other site 935593003608 Switch II region; other site 935593003609 G4 box; other site 935593003610 G5 box; other site 935593003611 Putative exonuclease, RdgC; Region: RdgC; cl01122 935593003612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 935593003613 MORN repeat; Region: MORN; cl14787 935593003614 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 935593003615 trimer interface [polypeptide binding]; other site 935593003616 active site 935593003617 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3471 935593003618 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 935593003619 PhoH-like protein; Region: PhoH; pfam02562 935593003620 poly(A) polymerase; Region: pcnB; TIGR01942 935593003621 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 935593003622 active site 935593003623 NTP binding site [chemical binding]; other site 935593003624 metal binding triad [ion binding]; metal-binding site 935593003625 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 935593003626 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 935593003627 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 935593003628 DHH family; Region: DHH; pfam01368 935593003629 DHHA1 domain; Region: DHHA1; pfam02272 935593003630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 935593003631 peptidase PmbA; Provisional; Region: PRK11040 935593003632 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 935593003633 DNA-binding site [nucleotide binding]; DNA binding site 935593003634 RNA-binding motif; other site 935593003635 Uncharacterized conserved protein [Function unknown]; Region: COG2127 935593003636 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 935593003637 Clp amino terminal domain; Region: Clp_N; pfam02861 935593003638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593003639 Walker A motif; other site 935593003640 ATP binding site [chemical binding]; other site 935593003641 Walker B motif; other site 935593003642 arginine finger; other site 935593003643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593003644 Walker A motif; other site 935593003645 ATP binding site [chemical binding]; other site 935593003646 Walker B motif; other site 935593003647 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 935593003648 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 935593003649 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 935593003650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935593003651 ATP binding site [chemical binding]; other site 935593003652 putative Mg++ binding site [ion binding]; other site 935593003653 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 935593003654 HsdM N-terminal domain; Region: HsdM_N; pfam12161 935593003655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593003656 S-adenosylmethionine binding site [chemical binding]; other site 935593003657 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 935593003658 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 935593003659 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 935593003660 NADP binding site [chemical binding]; other site 935593003661 homopentamer interface [polypeptide binding]; other site 935593003662 substrate binding site [chemical binding]; other site 935593003663 active site 935593003664 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 935593003665 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935593003666 cofactor binding site; other site 935593003667 DNA binding site [nucleotide binding] 935593003668 substrate interaction site [chemical binding]; other site 935593003669 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935593003670 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 935593003671 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 935593003672 putative ribose interaction site [chemical binding]; other site 935593003673 putative ADP binding site [chemical binding]; other site 935593003674 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 935593003675 active site 935593003676 dimer interface [polypeptide binding]; other site 935593003677 adenylate kinase; Reviewed; Region: adk; PRK00279 935593003678 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 935593003679 AMP-binding site [chemical binding]; other site 935593003680 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 935593003681 heat shock protein HtpX; Provisional; Region: PRK05457 935593003682 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935593003683 NUMOD1 domain; Region: NUMOD1; pfam07453 935593003684 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935593003685 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 935593003686 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935593003687 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935593003688 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 935593003689 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 935593003690 GDP-binding site [chemical binding]; other site 935593003691 ACT binding site; other site 935593003692 IMP binding site; other site 935593003693 ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705 935593003694 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935593003695 motif 1; other site 935593003696 dimer interface [polypeptide binding]; other site 935593003697 active site 935593003698 motif 2; other site 935593003699 motif 3; other site 935593003700 multidrug efflux protein; Reviewed; Region: PRK01766 935593003701 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 935593003702 cation binding site [ion binding]; other site 935593003703 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 935593003704 FAD binding domain; Region: FAD_binding_4; pfam01565 935593003705 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 935593003706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935593003707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935593003708 Bacterial transcriptional repressor; Region: TetR; pfam13972 935593003709 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 935593003710 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 935593003711 putative NAD(P) binding site [chemical binding]; other site 935593003712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 935593003713 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04539 935593003714 ATP-NAD kinase; Region: NAD_kinase; pfam01513 935593003715 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 935593003716 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935593003717 RNA binding surface [nucleotide binding]; other site 935593003718 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 935593003719 active site 935593003720 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593003721 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593003722 Homeodomain-like domain; Region: HTH_32; pfam13565 935593003723 Integrase core domain; Region: rve; pfam00665 935593003724 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 935593003725 dimer interface [polypeptide binding]; other site 935593003726 FMN binding site [chemical binding]; other site 935593003727 putative GTP cyclohydrolase; Provisional; Region: PRK13674 935593003728 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 935593003729 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 935593003730 homodimer interface [polypeptide binding]; other site 935593003731 substrate-cofactor binding pocket; other site 935593003732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593003733 catalytic residue [active] 935593003734 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 935593003735 dimer interface [polypeptide binding]; other site 935593003736 active site 935593003737 aspartate-rich active site metal binding site; other site 935593003738 allosteric magnesium binding site [ion binding]; other site 935593003739 Schiff base residues; other site 935593003740 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 935593003741 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 935593003742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593003743 S-adenosylmethionine binding site [chemical binding]; other site 935593003744 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 935593003745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593003746 Walker A motif; other site 935593003747 ATP binding site [chemical binding]; other site 935593003748 Walker B motif; other site 935593003749 arginine finger; other site 935593003750 Peptidase family M41; Region: Peptidase_M41; pfam01434 935593003751 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 935593003752 putative coenzyme Q binding site [chemical binding]; other site 935593003753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 935593003754 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 935593003755 putative active site [active] 935593003756 catalytic residue [active] 935593003757 VanZ like family; Region: VanZ; cl01971 935593003758 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 935593003759 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 935593003760 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 935593003761 active site 935593003762 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 935593003763 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 935593003764 active site 935593003765 substrate binding site [chemical binding]; other site 935593003766 metal binding site [ion binding]; metal-binding site 935593003767 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 935593003768 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 935593003769 Walker A/P-loop; other site 935593003770 ATP binding site [chemical binding]; other site 935593003771 Q-loop/lid; other site 935593003772 ABC transporter signature motif; other site 935593003773 Walker B; other site 935593003774 D-loop; other site 935593003775 H-loop/switch region; other site 935593003776 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 935593003777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935593003778 dimer interface [polypeptide binding]; other site 935593003779 conserved gate region; other site 935593003780 putative PBP binding loops; other site 935593003781 ABC-ATPase subunit interface; other site 935593003782 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 935593003783 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 935593003784 substrate binding pocket [chemical binding]; other site 935593003785 membrane-bound complex binding site; other site 935593003786 hinge residues; other site 935593003787 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 935593003788 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 935593003789 Part of AAA domain; Region: AAA_19; pfam13245 935593003790 Family description; Region: UvrD_C_2; pfam13538 935593003791 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 935593003792 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 935593003793 active site residue [active] 935593003794 Uncharacterized conserved protein [Function unknown]; Region: COG3439 935593003795 DNA repair protein RadA; Provisional; Region: PRK11823 935593003796 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 935593003797 Walker A motif/ATP binding site; other site 935593003798 ATP binding site [chemical binding]; other site 935593003799 Walker B motif; other site 935593003800 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 935593003801 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 935593003802 substrate binding site [chemical binding]; other site 935593003803 active site 935593003804 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 935593003805 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 935593003806 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 935593003807 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 935593003808 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 935593003809 active site 935593003810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4390 935593003811 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935593003812 active site 935593003813 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 935593003814 putative GSH binding site [chemical binding]; other site 935593003815 catalytic residues [active] 935593003816 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 935593003817 Domain of unknown function (DUF333); Region: DUF333; pfam03891 935593003818 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 935593003819 active site 935593003820 Tfp pilus assembly protein PilZ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilZ; COG3215 935593003821 DNA polymerase III subunit delta'; Validated; Region: PRK08699 935593003822 DNA polymerase III subunit delta'; Validated; Region: PRK08485 935593003823 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 935593003824 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 935593003825 Walker A motif; other site 935593003826 ATP binding site [chemical binding]; other site 935593003827 Walker B motif; other site 935593003828 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 935593003829 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 935593003830 GTP-binding protein LepA; Provisional; Region: PRK05433 935593003831 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 935593003832 G1 box; other site 935593003833 putative GEF interaction site [polypeptide binding]; other site 935593003834 GTP/Mg2+ binding site [chemical binding]; other site 935593003835 Switch I region; other site 935593003836 G2 box; other site 935593003837 G3 box; other site 935593003838 Switch II region; other site 935593003839 G4 box; other site 935593003840 G5 box; other site 935593003841 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 935593003842 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 935593003843 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 935593003844 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 935593003845 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 935593003846 Catalytic site [active] 935593003847 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 935593003848 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 935593003849 EamA-like transporter family; Region: EamA; pfam00892 935593003850 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 935593003851 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 935593003852 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 935593003853 dimer interface [polypeptide binding]; other site 935593003854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593003855 catalytic residue [active] 935593003856 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 935593003857 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 935593003858 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 935593003859 Uncharacterized conserved protein [Function unknown]; Region: COG2836 935593003860 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 935593003861 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 935593003862 RNase E interface [polypeptide binding]; other site 935593003863 trimer interface [polypeptide binding]; other site 935593003864 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 935593003865 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 935593003866 RNase E interface [polypeptide binding]; other site 935593003867 trimer interface [polypeptide binding]; other site 935593003868 active site 935593003869 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 935593003870 putative nucleic acid binding region [nucleotide binding]; other site 935593003871 G-X-X-G motif; other site 935593003872 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 935593003873 RNA binding site [nucleotide binding]; other site 935593003874 domain interface; other site 935593003875 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 935593003876 ATP binding site [chemical binding]; other site 935593003877 active site 935593003878 substrate binding site [chemical binding]; other site 935593003879 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 935593003880 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 935593003881 NADP binding site [chemical binding]; other site 935593003882 active site 935593003883 putative substrate binding site [chemical binding]; other site 935593003884 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 935593003885 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 935593003886 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 935593003887 active site 935593003888 Int/Topo IB signature motif; other site 935593003889 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 935593003890 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 935593003891 catalytic triad [active] 935593003892 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 935593003893 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 935593003894 bacterial Hfq-like; Region: Hfq; cd01716 935593003895 hexamer interface [polypeptide binding]; other site 935593003896 Sm1 motif; other site 935593003897 RNA binding site [nucleotide binding]; other site 935593003898 Sm2 motif; other site 935593003899 Methyltransferase domain; Region: Methyltransf_31; pfam13847 935593003900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593003901 S-adenosylmethionine binding site [chemical binding]; other site 935593003902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094 935593003903 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 935593003904 catalytic center binding site [active] 935593003905 ATP binding site [chemical binding]; other site 935593003906 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 935593003907 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 935593003908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593003909 S-adenosylmethionine binding site [chemical binding]; other site 935593003910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 935593003911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 935593003912 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 935593003913 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 935593003914 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 935593003915 Walker A/P-loop; other site 935593003916 ATP binding site [chemical binding]; other site 935593003917 Q-loop/lid; other site 935593003918 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 935593003919 ABC transporter signature motif; other site 935593003920 Walker B; other site 935593003921 D-loop; other site 935593003922 H-loop/switch region; other site 935593003923 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 935593003924 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 935593003925 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 935593003926 GTP/Mg2+ binding site [chemical binding]; other site 935593003927 G4 box; other site 935593003928 G5 box; other site 935593003929 G1 box; other site 935593003930 Switch I region; other site 935593003931 G2 box; other site 935593003932 G3 box; other site 935593003933 Switch II region; other site 935593003934 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 935593003935 AAA domain; Region: AAA_33; pfam13671 935593003936 HPr kinase/phosphorylase; Provisional; Region: PRK05428 935593003937 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 935593003938 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 935593003939 Hpr binding site; other site 935593003940 active site 935593003941 homohexamer subunit interaction site [polypeptide binding]; other site 935593003942 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 935593003943 active site 935593003944 phosphorylation site [posttranslational modification] 935593003945 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 935593003946 UbiA prenyltransferase family; Region: UbiA; pfam01040 935593003947 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 935593003948 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 935593003949 AAA domain; Region: AAA_26; pfam13500 935593003950 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 935593003951 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935593003952 inhibitor-cofactor binding pocket; inhibition site 935593003953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593003954 catalytic residue [active] 935593003955 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 935593003956 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 935593003957 IHF - DNA interface [nucleotide binding]; other site 935593003958 IHF dimer interface [polypeptide binding]; other site 935593003959 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 935593003960 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 935593003961 putative tRNA-binding site [nucleotide binding]; other site 935593003962 B3/4 domain; Region: B3_4; pfam03483 935593003963 tRNA synthetase B5 domain; Region: B5; smart00874 935593003964 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 935593003965 dimer interface [polypeptide binding]; other site 935593003966 motif 1; other site 935593003967 motif 3; other site 935593003968 motif 2; other site 935593003969 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 935593003970 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 935593003971 DNA methylase; Region: N6_N4_Mtase; cl17433 935593003972 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 935593003973 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 935593003974 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 935593003975 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935593003976 cofactor binding site; other site 935593003977 DNA binding site [nucleotide binding] 935593003978 substrate interaction site [chemical binding]; other site 935593003979 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 935593003980 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 935593003981 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 935593003982 dimer interface [polypeptide binding]; other site 935593003983 motif 1; other site 935593003984 active site 935593003985 motif 2; other site 935593003986 motif 3; other site 935593003987 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 935593003988 23S rRNA binding site [nucleotide binding]; other site 935593003989 L21 binding site [polypeptide binding]; other site 935593003990 L13 binding site [polypeptide binding]; other site 935593003991 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 935593003992 translation initiation factor IF-3; Region: infC; TIGR00168 935593003993 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 935593003994 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 935593003995 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 935593003996 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 935593003997 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 935593003998 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 935593003999 active site 935593004000 dimer interface [polypeptide binding]; other site 935593004001 motif 1; other site 935593004002 motif 2; other site 935593004003 motif 3; other site 935593004004 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 935593004005 anticodon binding site; other site 935593004006 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 935593004007 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 935593004008 ferrochelatase; Reviewed; Region: hemH; PRK00035 935593004009 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 935593004010 C-terminal domain interface [polypeptide binding]; other site 935593004011 active site 935593004012 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 935593004013 active site 935593004014 N-terminal domain interface [polypeptide binding]; other site 935593004015 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 935593004016 Cytochrome c; Region: Cytochrom_C; pfam00034 935593004017 potassium/proton antiporter; Reviewed; Region: PRK05326 935593004018 potassium/proton antiporter; Reviewed; Region: PRK05326 935593004019 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 935593004020 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 935593004021 putative active site [active] 935593004022 catalytic triad [active] 935593004023 putative dimer interface [polypeptide binding]; other site 935593004024 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 935593004025 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 935593004026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935593004027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935593004028 DNA binding residues [nucleotide binding] 935593004029 hypothetical protein; Provisional; Region: PRK11820 935593004030 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 935593004031 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 935593004032 Predicted membrane protein/domain [Function unknown]; Region: COG1714 935593004033 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 935593004034 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 935593004035 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 935593004036 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 935593004037 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 935593004038 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 935593004039 Sodium Bile acid symporter family; Region: SBF; pfam01758 935593004040 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 935593004041 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935593004042 RNA binding surface [nucleotide binding]; other site 935593004043 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 935593004044 active site 935593004045 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 935593004046 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 935593004047 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 935593004048 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 935593004049 Competence protein; Region: Competence; pfam03772 935593004050 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 935593004051 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 935593004052 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 935593004053 Autotransporter beta-domain; Region: Autotransporter; pfam03797 935593004054 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 935593004055 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 935593004056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593004057 catalytic residue [active] 935593004058 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 935593004059 putative active site [active] 935593004060 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 935593004061 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 935593004062 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 935593004063 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 935593004064 Walker A/P-loop; other site 935593004065 ATP binding site [chemical binding]; other site 935593004066 Q-loop/lid; other site 935593004067 ABC transporter signature motif; other site 935593004068 Walker B; other site 935593004069 D-loop; other site 935593004070 H-loop/switch region; other site 935593004071 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 935593004072 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935593004073 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935593004074 cell division protein FtsN; Region: ftsN; TIGR02223 935593004075 Sporulation related domain; Region: SPOR; pfam05036 935593004076 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 935593004077 Colicin V production protein; Region: Colicin_V; pfam02674 935593004078 amidophosphoribosyltransferase; Provisional; Region: PRK09246 935593004079 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 935593004080 active site 935593004081 tetramer interface [polypeptide binding]; other site 935593004082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935593004083 active site 935593004084 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 935593004085 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 935593004086 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 935593004087 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 935593004088 active site 935593004089 GTPase Era; Reviewed; Region: era; PRK00089 935593004090 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 935593004091 G1 box; other site 935593004092 GTP/Mg2+ binding site [chemical binding]; other site 935593004093 Switch I region; other site 935593004094 G2 box; other site 935593004095 Switch II region; other site 935593004096 G3 box; other site 935593004097 G4 box; other site 935593004098 G5 box; other site 935593004099 KH domain; Region: KH_2; pfam07650 935593004100 ribonuclease III; Reviewed; Region: rnc; PRK00102 935593004101 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 935593004102 dimerization interface [polypeptide binding]; other site 935593004103 active site 935593004104 metal binding site [ion binding]; metal-binding site 935593004105 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 935593004106 dsRNA binding site [nucleotide binding]; other site 935593004107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4859 935593004108 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 935593004109 homopentamer interface [polypeptide binding]; other site 935593004110 active site 935593004111 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 935593004112 putative RNA binding site [nucleotide binding]; other site 935593004113 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 935593004114 active site 935593004115 substrate binding pocket [chemical binding]; other site 935593004116 dimer interface [polypeptide binding]; other site 935593004117 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 935593004118 CPxP motif; other site 935593004119 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 935593004120 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 935593004121 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 935593004122 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 935593004123 substrate binding site [chemical binding]; other site 935593004124 active site 935593004125 catalytic residues [active] 935593004126 heterodimer interface [polypeptide binding]; other site 935593004127 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 935593004128 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 935593004129 Ligand binding site; other site 935593004130 oligomer interface; other site 935593004131 Uncharacterized conserved protein [Function unknown]; Region: COG2835 935593004132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 935593004133 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 935593004134 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 935593004135 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 935593004136 Malic enzyme, N-terminal domain; Region: malic; pfam00390 935593004137 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 935593004138 putative NAD(P) binding site [chemical binding]; other site 935593004139 thymidylate kinase; Validated; Region: tmk; PRK00698 935593004140 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 935593004141 TMP-binding site; other site 935593004142 ATP-binding site [chemical binding]; other site 935593004143 YceG-like family; Region: YceG; pfam02618 935593004144 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 935593004145 dimerization interface [polypeptide binding]; other site 935593004146 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 935593004147 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 935593004148 amidase catalytic site [active] 935593004149 Zn binding residues [ion binding]; other site 935593004150 substrate binding site [chemical binding]; other site 935593004151 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 935593004152 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 935593004153 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 935593004154 nucleotide binding pocket [chemical binding]; other site 935593004155 K-X-D-G motif; other site 935593004156 catalytic site [active] 935593004157 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 935593004158 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 935593004159 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 935593004160 Dimer interface [polypeptide binding]; other site 935593004161 BRCT sequence motif; other site 935593004162 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 935593004163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935593004164 FeS/SAM binding site; other site 935593004165 HemN C-terminal domain; Region: HemN_C; pfam06969 935593004166 Opacity family porin protein; Region: Opacity; pfam02462 935593004167 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 935593004168 homotrimer interaction site [polypeptide binding]; other site 935593004169 putative active site [active] 935593004170 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 935593004171 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 935593004172 active site 935593004173 metal binding site [ion binding]; metal-binding site 935593004174 Cation transport protein; Region: TrkH; cl17365 935593004175 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 935593004176 Pretoxin HINT domain; Region: PT-HINT; pfam07591 935593004177 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 935593004178 thioester formation/cholesterol transfer; other site 935593004179 protein-splicing catalytic site; other site 935593004180 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935593004181 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 935593004182 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935593004183 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 935593004184 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 935593004185 RNAase interaction site [polypeptide binding]; other site 935593004186 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935593004187 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 935593004188 nudix motif; other site 935593004189 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 935593004190 dimer interface [polypeptide binding]; other site 935593004191 substrate binding site [chemical binding]; other site 935593004192 metal binding sites [ion binding]; metal-binding site 935593004193 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 935593004194 active site 935593004195 dimerization interface [polypeptide binding]; other site 935593004196 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 935593004197 active site 935593004198 tetramer interface; other site 935593004199 argininosuccinate lyase; Provisional; Region: PRK00855 935593004200 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 935593004201 active sites [active] 935593004202 tetramer interface [polypeptide binding]; other site 935593004203 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 935593004204 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 935593004205 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 935593004206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935593004207 dimer interface [polypeptide binding]; other site 935593004208 conserved gate region; other site 935593004209 putative PBP binding loops; other site 935593004210 ABC-ATPase subunit interface; other site 935593004211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935593004212 dimer interface [polypeptide binding]; other site 935593004213 conserved gate region; other site 935593004214 ABC-ATPase subunit interface; other site 935593004215 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 935593004216 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 935593004217 Walker A/P-loop; other site 935593004218 ATP binding site [chemical binding]; other site 935593004219 Q-loop/lid; other site 935593004220 ABC transporter signature motif; other site 935593004221 Walker B; other site 935593004222 D-loop; other site 935593004223 H-loop/switch region; other site 935593004224 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 935593004225 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 935593004226 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 935593004227 putative active site [active] 935593004228 oxyanion strand; other site 935593004229 catalytic triad [active] 935593004230 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 935593004231 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 935593004232 catalytic residues [active] 935593004233 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 935593004234 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 935593004235 substrate binding site [chemical binding]; other site 935593004236 glutamase interaction surface [polypeptide binding]; other site 935593004237 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 935593004238 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 935593004239 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 935593004240 G1 box; other site 935593004241 putative GEF interaction site [polypeptide binding]; other site 935593004242 GTP/Mg2+ binding site [chemical binding]; other site 935593004243 Switch I region; other site 935593004244 G2 box; other site 935593004245 G3 box; other site 935593004246 Switch II region; other site 935593004247 G4 box; other site 935593004248 G5 box; other site 935593004249 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 935593004250 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 935593004251 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 935593004252 trimer interface [polypeptide binding]; other site 935593004253 putative metal binding site [ion binding]; other site 935593004254 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 935593004255 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935593004256 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 935593004257 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 935593004258 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 935593004259 dinuclear metal binding motif [ion binding]; other site 935593004260 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 935593004261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935593004262 motif II; other site 935593004263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 935593004264 phosphoenolpyruvate synthase; Validated; Region: PRK06464 935593004265 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 935593004266 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 935593004267 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 935593004268 transcription termination factor Rho; Provisional; Region: rho; PRK09376 935593004269 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 935593004270 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 935593004271 RNA binding site [nucleotide binding]; other site 935593004272 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 935593004273 multimer interface [polypeptide binding]; other site 935593004274 Walker A motif; other site 935593004275 ATP binding site [chemical binding]; other site 935593004276 Walker B motif; other site 935593004277 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 935593004278 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 935593004279 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 935593004280 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 935593004281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935593004282 dimer interface [polypeptide binding]; other site 935593004283 conserved gate region; other site 935593004284 putative PBP binding loops; other site 935593004285 ABC-ATPase subunit interface; other site 935593004286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935593004287 dimer interface [polypeptide binding]; other site 935593004288 conserved gate region; other site 935593004289 putative PBP binding loops; other site 935593004290 ABC-ATPase subunit interface; other site 935593004291 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 935593004292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935593004293 Walker A/P-loop; other site 935593004294 ATP binding site [chemical binding]; other site 935593004295 Q-loop/lid; other site 935593004296 ABC transporter signature motif; other site 935593004297 Walker B; other site 935593004298 D-loop; other site 935593004299 H-loop/switch region; other site 935593004300 TOBE domain; Region: TOBE_2; pfam08402 935593004301 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 935593004302 16S/18S rRNA binding site [nucleotide binding]; other site 935593004303 S13e-L30e interaction site [polypeptide binding]; other site 935593004304 25S rRNA binding site [nucleotide binding]; other site 935593004305 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 935593004306 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 935593004307 Protein export membrane protein; Region: SecD_SecF; pfam02355 935593004308 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 935593004309 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 935593004310 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 935593004311 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 935593004312 Preprotein translocase subunit; Region: YajC; pfam02699 935593004313 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 935593004314 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 935593004315 putative active site [active] 935593004316 Zn binding site [ion binding]; other site 935593004317 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 935593004318 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 935593004319 putative NAD(P) binding site [chemical binding]; other site 935593004320 catalytic Zn binding site [ion binding]; other site 935593004321 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 935593004322 metal binding site [ion binding]; metal-binding site 935593004323 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 935593004324 nucleotide binding site/active site [active] 935593004325 HIT family signature motif; other site 935593004326 catalytic residue [active] 935593004327 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 935593004328 sec-independent translocase; Provisional; Region: PRK00708 935593004329 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 935593004330 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 935593004331 Maf-like protein; Region: Maf; pfam02545 935593004332 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 935593004333 active site 935593004334 dimer interface [polypeptide binding]; other site 935593004335 Predicted membrane protein [Function unknown]; Region: COG3308 935593004336 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 935593004337 O-Antigen ligase; Region: Wzy_C; pfam04932 935593004338 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 935593004339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 935593004340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935593004341 active site 935593004342 phosphorylation site [posttranslational modification] 935593004343 intermolecular recognition site; other site 935593004344 dimerization interface [polypeptide binding]; other site 935593004345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 935593004346 DNA binding site [nucleotide binding] 935593004347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 935593004348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935593004349 dimerization interface [polypeptide binding]; other site 935593004350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935593004351 dimer interface [polypeptide binding]; other site 935593004352 phosphorylation site [posttranslational modification] 935593004353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935593004354 ATP binding site [chemical binding]; other site 935593004355 Mg2+ binding site [ion binding]; other site 935593004356 G-X-G motif; other site 935593004357 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 935593004358 CoA binding domain; Region: CoA_binding_2; pfam13380 935593004359 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 935593004360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935593004361 Coenzyme A binding pocket [chemical binding]; other site 935593004362 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 935593004363 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 935593004364 RimM N-terminal domain; Region: RimM; pfam01782 935593004365 PRC-barrel domain; Region: PRC; pfam05239 935593004366 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 935593004367 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 935593004368 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 935593004369 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 935593004370 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 935593004371 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935593004372 ABC-ATPase subunit interface; other site 935593004373 dimer interface [polypeptide binding]; other site 935593004374 putative PBP binding regions; other site 935593004375 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 935593004376 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 935593004377 metal binding site [ion binding]; metal-binding site 935593004378 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 935593004379 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 935593004380 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 935593004381 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 935593004382 RTX iron-regulated protein FrpC; Region: FrpC; pfam06901 935593004383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935593004384 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 935593004385 putative active site [active] 935593004386 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 935593004387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935593004388 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 935593004389 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 935593004390 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 935593004391 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 935593004392 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 935593004393 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 935593004394 tRNA; other site 935593004395 putative tRNA binding site [nucleotide binding]; other site 935593004396 putative NADP binding site [chemical binding]; other site 935593004397 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 935593004398 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 935593004399 lipoyl attachment site [posttranslational modification]; other site 935593004400 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 935593004401 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 935593004402 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 935593004403 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935593004404 putative DNA binding site [nucleotide binding]; other site 935593004405 putative Zn2+ binding site [ion binding]; other site 935593004406 AsnC family; Region: AsnC_trans_reg; pfam01037 935593004407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3310 935593004408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 935593004409 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 935593004410 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 935593004411 transmembrane helices; other site 935593004412 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 935593004413 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935593004414 E3 interaction surface; other site 935593004415 lipoyl attachment site [posttranslational modification]; other site 935593004416 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 935593004417 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 935593004418 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 935593004419 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 935593004420 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 935593004421 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 935593004422 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 935593004423 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935593004424 catalytic loop [active] 935593004425 iron binding site [ion binding]; other site 935593004426 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 935593004427 FAD binding pocket [chemical binding]; other site 935593004428 FAD binding motif [chemical binding]; other site 935593004429 phosphate binding motif [ion binding]; other site 935593004430 beta-alpha-beta structure motif; other site 935593004431 NAD binding pocket [chemical binding]; other site 935593004432 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593004433 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593004434 Homeodomain-like domain; Region: HTH_32; pfam13565 935593004435 Integrase core domain; Region: rve; pfam00665 935593004436 Transposase domain (DUF772); Region: DUF772; pfam05598 935593004437 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593004438 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593004439 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 935593004440 ApbE family; Region: ApbE; pfam02424 935593004441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 935593004442 serine acetyltransferase; Provisional; Region: cysE; PRK11132 935593004443 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 935593004444 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 935593004445 trimer interface [polypeptide binding]; other site 935593004446 active site 935593004447 substrate binding site [chemical binding]; other site 935593004448 CoA binding site [chemical binding]; other site 935593004449 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 935593004450 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 935593004451 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 935593004452 Predicted transcriptional regulator [Transcription]; Region: COG2932 935593004453 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935593004454 Catalytic site [active] 935593004455 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 935593004456 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 935593004457 nucleotide binding site [chemical binding]; other site 935593004458 NEF interaction site [polypeptide binding]; other site 935593004459 SBD interface [polypeptide binding]; other site 935593004460 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 935593004461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935593004462 ATP binding site [chemical binding]; other site 935593004463 putative Mg++ binding site [ion binding]; other site 935593004464 helicase superfamily c-terminal domain; Region: HELICc; smart00490 935593004465 ATP-binding site [chemical binding]; other site 935593004466 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 935593004467 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 935593004468 dimerization domain [polypeptide binding]; other site 935593004469 dimer interface [polypeptide binding]; other site 935593004470 catalytic residues [active] 935593004471 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 935593004472 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 935593004473 Walker A/P-loop; other site 935593004474 ATP binding site [chemical binding]; other site 935593004475 Q-loop/lid; other site 935593004476 ABC transporter signature motif; other site 935593004477 Walker B; other site 935593004478 D-loop; other site 935593004479 H-loop/switch region; other site 935593004480 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 935593004481 FtsX-like permease family; Region: FtsX; pfam02687 935593004482 macrolide transporter subunit MacA; Provisional; Region: PRK11578 935593004483 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935593004484 HlyD family secretion protein; Region: HlyD_3; pfam13437 935593004485 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 935593004486 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 935593004487 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 935593004488 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 935593004489 NAD binding site [chemical binding]; other site 935593004490 substrate binding site [chemical binding]; other site 935593004491 catalytic Zn binding site [ion binding]; other site 935593004492 tetramer interface [polypeptide binding]; other site 935593004493 structural Zn binding site [ion binding]; other site 935593004494 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 935593004495 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 935593004496 Walker A/P-loop; other site 935593004497 ATP binding site [chemical binding]; other site 935593004498 Q-loop/lid; other site 935593004499 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 935593004500 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 935593004501 ABC transporter signature motif; other site 935593004502 Walker B; other site 935593004503 D-loop; other site 935593004504 H-loop/switch region; other site 935593004505 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 935593004506 putative active site [active] 935593004507 putative metal binding site [ion binding]; other site 935593004508 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 935593004509 L-lactate permease; Region: Lactate_perm; cl00701 935593004510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 935593004511 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 935593004512 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 935593004513 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935593004514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593004515 homodimer interface [polypeptide binding]; other site 935593004516 catalytic residue [active] 935593004517 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 935593004518 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 935593004519 domain interfaces; other site 935593004520 active site 935593004521 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 935593004522 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 935593004523 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 935593004524 Transporter associated domain; Region: CorC_HlyC; smart01091 935593004525 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 935593004526 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 935593004527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935593004528 putative substrate translocation pore; other site 935593004529 Predicted membrane protein [Function unknown]; Region: COG1238 935593004530 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 935593004531 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 935593004532 minor groove reading motif; other site 935593004533 helix-hairpin-helix signature motif; other site 935593004534 substrate binding pocket [chemical binding]; other site 935593004535 active site 935593004536 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 935593004537 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 935593004538 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 935593004539 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 935593004540 protein binding site [polypeptide binding]; other site 935593004541 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 935593004542 protein binding site [polypeptide binding]; other site 935593004543 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 935593004544 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 935593004545 beta-hexosaminidase; Provisional; Region: PRK05337 935593004546 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 935593004547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935593004548 FeS/SAM binding site; other site 935593004549 Predicted membrane protein [Function unknown]; Region: COG3759 935593004550 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 935593004551 active site 935593004552 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 935593004553 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 935593004554 Ligand Binding Site [chemical binding]; other site 935593004555 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 935593004556 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 935593004557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935593004558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 935593004559 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935593004560 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004561 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935593004562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 935593004563 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004564 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935593004565 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004566 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935593004567 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004568 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935593004569 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 935593004570 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004571 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935593004572 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935593004573 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 935593004574 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004575 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935593004576 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935593004577 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 935593004578 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 935593004579 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 935593004580 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 935593004581 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 935593004582 Initiator Replication protein; Region: Rep_3; pfam01051 935593004583 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935593004584 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004585 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935593004586 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935593004587 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935593004588 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935593004589 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 935593004590 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935593004591 Replication initiation factor; Region: Rep_trans; pfam02486 935593004592 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935593004593 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 935593004594 Zonular occludens toxin (Zot); Region: Zot; pfam05707 935593004595 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 935593004596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935593004597 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935593004598 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935593004599 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935593004600 Integrase core domain; Region: rve; pfam00665 935593004601 Integrase core domain; Region: rve_2; pfam13333 935593004602 Helix-turn-helix domain; Region: HTH_28; pfam13518 935593004603 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 935593004604 Fic family protein [Function unknown]; Region: COG3177 935593004605 Fic/DOC family; Region: Fic; pfam02661 935593004606 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 935593004607 HipA N-terminal domain; Region: Couple_hipA; pfam13657 935593004608 HipA-like N-terminal domain; Region: HipA_N; pfam07805 935593004609 HipA-like C-terminal domain; Region: HipA_C; pfam07804 935593004610 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 935593004611 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 935593004612 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 935593004613 RTX toxin acyltransferase family; Region: HlyC; cl01131 935593004614 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593004615 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593004616 Homeodomain-like domain; Region: HTH_32; pfam13565 935593004617 Integrase core domain; Region: rve; pfam00665 935593004618 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004619 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935593004620 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935593004621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 935593004622 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004623 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935593004624 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004625 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935593004626 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935593004627 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935593004628 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935593004629 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 935593004630 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 935593004631 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 935593004632 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 935593004633 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 935593004634 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 935593004635 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 935593004636 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 935593004637 generic binding surface II; other site 935593004638 ssDNA binding site; other site 935593004639 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935593004640 ATP binding site [chemical binding]; other site 935593004641 putative Mg++ binding site [ion binding]; other site 935593004642 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935593004643 nucleotide binding region [chemical binding]; other site 935593004644 ATP-binding site [chemical binding]; other site 935593004645 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 935593004646 SecA binding site; other site 935593004647 Preprotein binding site; other site 935593004648 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 935593004649 GSH binding site [chemical binding]; other site 935593004650 catalytic residues [active] 935593004651 ribonuclease G; Provisional; Region: PRK11712 935593004652 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 935593004653 homodimer interface [polypeptide binding]; other site 935593004654 oligonucleotide binding site [chemical binding]; other site 935593004655 sensor protein QseC; Provisional; Region: PRK10337 935593004656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935593004657 dimer interface [polypeptide binding]; other site 935593004658 phosphorylation site [posttranslational modification] 935593004659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935593004660 ATP binding site [chemical binding]; other site 935593004661 Mg2+ binding site [ion binding]; other site 935593004662 G-X-G motif; other site 935593004663 cheY-homologous receiver domain; Region: REC; smart00448 935593004664 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 935593004665 Citrate transporter; Region: CitMHS; pfam03600 935593004666 Predicted flavoprotein [General function prediction only]; Region: COG0431 935593004667 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 935593004668 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 935593004669 Transposase domain (DUF772); Region: DUF772; pfam05598 935593004670 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593004671 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935593004672 Transposase domain (DUF772); Region: DUF772; pfam05598 935593004673 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593004674 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593004675 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 935593004676 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935593004677 HlyD family secretion protein; Region: HlyD_3; pfam13437 935593004678 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 935593004679 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 935593004680 putative active site [active] 935593004681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935593004682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935593004683 Walker A/P-loop; other site 935593004684 ATP binding site [chemical binding]; other site 935593004685 Q-loop/lid; other site 935593004686 ABC transporter signature motif; other site 935593004687 Walker B; other site 935593004688 D-loop; other site 935593004689 H-loop/switch region; other site 935593004690 Uncharacterized conserved protein [Function unknown]; Region: COG2850 935593004691 Cupin-like domain; Region: Cupin_8; pfam13621 935593004692 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 935593004693 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593004694 Transposase domain (DUF772); Region: DUF772; pfam05598 935593004695 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593004696 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593004697 S-adenosylmethionine synthetase; Validated; Region: PRK05250 935593004698 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 935593004699 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 935593004700 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 935593004701 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 935593004702 putative acyl-acceptor binding pocket; other site 935593004703 UGMP family protein; Validated; Region: PRK09604 935593004704 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 935593004705 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 935593004706 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 935593004707 ResB-like family; Region: ResB; pfam05140 935593004708 Cytochrome c553 [Energy production and conversion]; Region: COG2863 935593004709 Cytochrome c; Region: Cytochrom_C; cl11414 935593004710 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 935593004711 G1 box; other site 935593004712 GTP/Mg2+ binding site [chemical binding]; other site 935593004713 Switch I region; other site 935593004714 G2 box; other site 935593004715 G3 box; other site 935593004716 Switch II region; other site 935593004717 G4 box; other site 935593004718 G5 box; other site 935593004719 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 935593004720 Transglycosylase; Region: Transgly; pfam00912 935593004721 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 935593004722 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 935593004723 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 935593004724 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 935593004725 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 935593004726 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 935593004727 Pilus assembly protein, PilP; Region: PilP; pfam04351 935593004728 AMIN domain; Region: AMIN; pfam11741 935593004729 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 935593004730 Secretin and TonB N terminus short domain; Region: STN; pfam07660 935593004731 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 935593004732 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 935593004733 shikimate kinase; Reviewed; Region: aroK; PRK00131 935593004734 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 935593004735 ADP binding site [chemical binding]; other site 935593004736 magnesium binding site [ion binding]; other site 935593004737 putative shikimate binding site; other site 935593004738 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 935593004739 active site 935593004740 dimer interface [polypeptide binding]; other site 935593004741 metal binding site [ion binding]; metal-binding site 935593004742 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 935593004743 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 935593004744 putative active site [active] 935593004745 putative dimer interface [polypeptide binding]; other site 935593004746 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 935593004747 ATP cone domain; Region: ATP-cone; pfam03477 935593004748 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 935593004749 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 935593004750 catalytic motif [active] 935593004751 Zn binding site [ion binding]; other site 935593004752 RibD C-terminal domain; Region: RibD_C; cl17279 935593004753 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 935593004754 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 935593004755 Bacterial sugar transferase; Region: Bac_transf; pfam02397 935593004756 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 935593004757 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 935593004758 putative trimer interface [polypeptide binding]; other site 935593004759 putative CoA binding site [chemical binding]; other site 935593004760 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 935593004761 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 935593004762 inhibitor-cofactor binding pocket; inhibition site 935593004763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593004764 catalytic residue [active] 935593004765 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 935593004766 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 935593004767 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 935593004768 NAD(P) binding site [chemical binding]; other site 935593004769 homodimer interface [polypeptide binding]; other site 935593004770 substrate binding site [chemical binding]; other site 935593004771 active site 935593004772 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and metabolism]; Region: COG3977 935593004773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935593004774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593004775 homodimer interface [polypeptide binding]; other site 935593004776 catalytic residue [active] 935593004777 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 935593004778 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 935593004779 active site 935593004780 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 935593004781 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935593004782 RNA binding surface [nucleotide binding]; other site 935593004783 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 935593004784 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 935593004785 putative active site [active] 935593004786 putative PHP Thumb interface [polypeptide binding]; other site 935593004787 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 935593004788 generic binding surface II; other site 935593004789 generic binding surface I; other site 935593004790 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 935593004791 Putative esterase; Region: Esterase; pfam00756 935593004792 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 935593004793 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935593004794 N-terminal plug; other site 935593004795 ligand-binding site [chemical binding]; other site 935593004796 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 935593004797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935593004798 motif II; other site 935593004799 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 935593004800 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 935593004801 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 935593004802 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 935593004803 lipoprotein signal peptidase; Provisional; Region: PRK14787 935593004804 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 935593004805 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935593004806 active site 935593004807 HIGH motif; other site 935593004808 nucleotide binding site [chemical binding]; other site 935593004809 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 935593004810 active site 935593004811 KMSKS motif; other site 935593004812 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 935593004813 tRNA binding surface [nucleotide binding]; other site 935593004814 anticodon binding site; other site 935593004815 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 935593004816 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 935593004817 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 935593004818 active site 935593004819 Riboflavin kinase; Region: Flavokinase; smart00904 935593004820 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 935593004821 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 935593004822 active site 935593004823 HIGH motif; other site 935593004824 dimer interface [polypeptide binding]; other site 935593004825 KMSKS motif; other site 935593004826 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 935593004827 GTP-binding protein YchF; Reviewed; Region: PRK09601 935593004828 YchF GTPase; Region: YchF; cd01900 935593004829 G1 box; other site 935593004830 GTP/Mg2+ binding site [chemical binding]; other site 935593004831 Switch I region; other site 935593004832 G2 box; other site 935593004833 Switch II region; other site 935593004834 G3 box; other site 935593004835 G4 box; other site 935593004836 G5 box; other site 935593004837 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 935593004838 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 935593004839 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 935593004840 Potassium binding sites [ion binding]; other site 935593004841 Cesium cation binding sites [ion binding]; other site 935593004842 Predicted membrane protein [Function unknown]; Region: COG2510 935593004843 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 935593004844 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 935593004845 Substrate binding site; other site 935593004846 metal-binding site 935593004847 4-hydroxyphenylacetate 3-monooxygenase, reductase component; Region: HpaC; TIGR02296 935593004848 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 935593004849 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 935593004850 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 935593004851 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935593004852 antiporter inner membrane protein; Provisional; Region: PRK11670 935593004853 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 935593004854 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 935593004855 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 935593004856 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 935593004857 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 935593004858 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 935593004859 catalytic site [active] 935593004860 subunit interface [polypeptide binding]; other site 935593004861 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 935593004862 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935593004863 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 935593004864 putative active site [active] 935593004865 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 935593004866 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935593004867 active site 935593004868 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 935593004869 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935593004870 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 935593004871 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 935593004872 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935593004873 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935593004874 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 935593004875 IMP binding site; other site 935593004876 dimer interface [polypeptide binding]; other site 935593004877 interdomain contacts; other site 935593004878 partial ornithine binding site; other site 935593004879 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935593004880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935593004881 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 935593004882 putative effector binding pocket; other site 935593004883 dimerization interface [polypeptide binding]; other site 935593004884 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 935593004885 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 935593004886 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 935593004887 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 935593004888 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 935593004889 carboxyltransferase (CT) interaction site; other site 935593004890 biotinylation site [posttranslational modification]; other site 935593004891 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 935593004892 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935593004893 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 935593004894 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 935593004895 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 935593004896 DNA methylase; Region: N6_N4_Mtase; cl17433 935593004897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593004898 S-adenosylmethionine binding site [chemical binding]; other site 935593004899 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 935593004900 catalytic site [active] 935593004901 putative active site [active] 935593004902 putative substrate binding site [chemical binding]; other site 935593004903 dimer interface [polypeptide binding]; other site 935593004904 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 935593004905 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935593004906 inhibitor-cofactor binding pocket; inhibition site 935593004907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593004908 catalytic residue [active] 935593004909 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 935593004910 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 935593004911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935593004912 FeS/SAM binding site; other site 935593004913 TRAM domain; Region: TRAM; pfam01938 935593004914 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 935593004915 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 935593004916 TPP-binding site; other site 935593004917 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 935593004918 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 935593004919 PYR/PP interface [polypeptide binding]; other site 935593004920 dimer interface [polypeptide binding]; other site 935593004921 TPP binding site [chemical binding]; other site 935593004922 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 935593004923 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 935593004924 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 935593004925 active site 935593004926 Int/Topo IB signature motif; other site 935593004927 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 935593004928 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 935593004929 intersubunit interface [polypeptide binding]; other site 935593004930 active site 935593004931 zinc binding site [ion binding]; other site 935593004932 Na+ binding site [ion binding]; other site 935593004933 Lipoprotein GNA1870 C terminal like; Region: Lipoprot_C; pfam08794 935593004934 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 935593004935 Glycoprotease family; Region: Peptidase_M22; pfam00814 935593004936 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 935593004937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935593004938 Coenzyme A binding pocket [chemical binding]; other site 935593004939 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 935593004940 active site 935593004941 Fe-S cluster binding site [ion binding]; other site 935593004942 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935593004943 active site 935593004944 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 935593004945 amino-acid N-acetyltransferase; Region: N-Ac-Glu-synth; TIGR01890 935593004946 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 935593004947 putative feedback inhibition sensing region; other site 935593004948 putative nucleotide binding site [chemical binding]; other site 935593004949 putative substrate binding site [chemical binding]; other site 935593004950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935593004951 Coenzyme A binding pocket [chemical binding]; other site 935593004952 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 935593004953 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 935593004954 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 935593004955 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 935593004956 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 935593004957 putative ligand binding residues [chemical binding]; other site 935593004958 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 935593004959 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 935593004960 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935593004961 N-terminal plug; other site 935593004962 ligand-binding site [chemical binding]; other site 935593004963 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 935593004964 active site residue [active] 935593004965 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 935593004966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593004967 S-adenosylmethionine binding site [chemical binding]; other site 935593004968 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 935593004969 triosephosphate isomerase; Provisional; Region: PRK14567 935593004970 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 935593004971 substrate binding site [chemical binding]; other site 935593004972 dimer interface [polypeptide binding]; other site 935593004973 catalytic triad [active] 935593004974 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 935593004975 Predicted transcriptional regulator [Transcription]; Region: COG2944 935593004976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935593004977 non-specific DNA binding site [nucleotide binding]; other site 935593004978 salt bridge; other site 935593004979 sequence-specific DNA binding site [nucleotide binding]; other site 935593004980 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 935593004981 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 935593004982 Dam-replacing family; Region: DRP; pfam06044 935593004983 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 935593004984 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 935593004985 HIGH motif; other site 935593004986 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 935593004987 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935593004988 active site 935593004989 KMSKS motif; other site 935593004990 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 935593004991 tRNA binding surface [nucleotide binding]; other site 935593004992 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 935593004993 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 935593004994 polyphosphate kinase; Provisional; Region: PRK05443 935593004995 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 935593004996 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 935593004997 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 935593004998 putative domain interface [polypeptide binding]; other site 935593004999 putative active site [active] 935593005000 catalytic site [active] 935593005001 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 935593005002 putative domain interface [polypeptide binding]; other site 935593005003 putative active site [active] 935593005004 catalytic site [active] 935593005005 DNA polymerase III subunit beta; Validated; Region: PRK05643 935593005006 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 935593005007 putative DNA binding surface [nucleotide binding]; other site 935593005008 dimer interface [polypeptide binding]; other site 935593005009 beta-clamp/clamp loader binding surface; other site 935593005010 beta-clamp/translesion DNA polymerase binding surface; other site 935593005011 DnaA N-terminal domain; Region: DnaA_N; pfam11638 935593005012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935593005013 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 935593005014 Walker A motif; other site 935593005015 ATP binding site [chemical binding]; other site 935593005016 Walker B motif; other site 935593005017 arginine finger; other site 935593005018 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 935593005019 DnaA box-binding interface [nucleotide binding]; other site 935593005020 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 935593005021 ribonuclease P; Reviewed; Region: rnpA; PRK04390 935593005022 hypothetical protein; Provisional; Region: PRK14373 935593005023 membrane protein insertase; Provisional; Region: PRK01318 935593005024 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 935593005025 Predicted methyltransferases [General function prediction only]; Region: COG0313 935593005026 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 935593005027 putative SAM binding site [chemical binding]; other site 935593005028 homodimer interface [polypeptide binding]; other site 935593005029 Maf-like protein; Region: Maf; pfam02545 935593005030 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 935593005031 active site 935593005032 dimer interface [polypeptide binding]; other site 935593005033 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 935593005034 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 935593005035 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 935593005036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935593005037 active site 935593005038 putative phosphate acyltransferase; Provisional; Region: PRK05331 935593005039 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 935593005040 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 935593005041 dimer interface [polypeptide binding]; other site 935593005042 active site 935593005043 CoA binding pocket [chemical binding]; other site 935593005044 Predicted membrane protein [Function unknown]; Region: COG3326 935593005045 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 935593005046 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 935593005047 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 935593005048 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935593005049 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 935593005050 Walker A/P-loop; other site 935593005051 ATP binding site [chemical binding]; other site 935593005052 Q-loop/lid; other site 935593005053 ABC transporter signature motif; other site 935593005054 Walker B; other site 935593005055 D-loop; other site 935593005056 H-loop/switch region; other site 935593005057 GMP synthase; Reviewed; Region: guaA; PRK00074 935593005058 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 935593005059 AMP/PPi binding site [chemical binding]; other site 935593005060 candidate oxyanion hole; other site 935593005061 catalytic triad [active] 935593005062 potential glutamine specificity residues [chemical binding]; other site 935593005063 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 935593005064 ATP Binding subdomain [chemical binding]; other site 935593005065 Ligand Binding sites [chemical binding]; other site 935593005066 Dimerization subdomain; other site 935593005067 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 935593005068 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 935593005069 NAD(P) binding site [chemical binding]; other site 935593005070 homotetramer interface [polypeptide binding]; other site 935593005071 homodimer interface [polypeptide binding]; other site 935593005072 active site 935593005073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 935593005074 Transposase domain (DUF772); Region: DUF772; pfam05598 935593005075 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593005076 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935593005077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 935593005078 SEC-C motif; Region: SEC-C; pfam02810 935593005079 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 935593005080 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935593005081 active site 935593005082 RNA methyltransferase, RsmE family; Region: TIGR00046 935593005083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 935593005084 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 935593005085 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 935593005086 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 935593005087 Ligand binding site; other site 935593005088 metal-binding site 935593005089 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 935593005090 active site 935593005091 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 935593005092 DALR anticodon binding domain; Region: DALR_1; pfam05746 935593005093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3171 935593005094 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 935593005095 dimer interface [polypeptide binding]; other site 935593005096 motif 1; other site 935593005097 active site 935593005098 motif 2; other site 935593005099 motif 3; other site 935593005100 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 935593005101 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 935593005102 gamma subunit interface [polypeptide binding]; other site 935593005103 epsilon subunit interface [polypeptide binding]; other site 935593005104 LBP interface [polypeptide binding]; other site 935593005105 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 935593005106 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 935593005107 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 935593005108 alpha subunit interaction interface [polypeptide binding]; other site 935593005109 Walker A motif; other site 935593005110 ATP binding site [chemical binding]; other site 935593005111 Walker B motif; other site 935593005112 inhibitor binding site; inhibition site 935593005113 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 935593005114 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 935593005115 core domain interface [polypeptide binding]; other site 935593005116 delta subunit interface [polypeptide binding]; other site 935593005117 epsilon subunit interface [polypeptide binding]; other site 935593005118 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 935593005119 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 935593005120 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 935593005121 beta subunit interaction interface [polypeptide binding]; other site 935593005122 Walker A motif; other site 935593005123 ATP binding site [chemical binding]; other site 935593005124 Walker B motif; other site 935593005125 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 935593005126 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 935593005127 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 935593005128 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 935593005129 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 935593005130 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 935593005131 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 935593005132 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 935593005133 F0F1-type ATP synthase, subunit I [Energy production and conversion]; Region: AtpI; COG3312 935593005134 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 935593005135 ParB-like nuclease domain; Region: ParBc; pfam02195 935593005136 KorB domain; Region: KorB; pfam08535 935593005137 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 935593005138 Flavoprotein; Region: Flavoprotein; pfam02441 935593005139 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 935593005140 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 935593005141 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 935593005142 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 935593005143 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 935593005144 Walker A/P-loop; other site 935593005145 ATP binding site [chemical binding]; other site 935593005146 Q-loop/lid; other site 935593005147 ABC transporter signature motif; other site 935593005148 Walker B; other site 935593005149 D-loop; other site 935593005150 H-loop/switch region; other site 935593005151 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 935593005152 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935593005153 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935593005154 catalytic residue [active] 935593005155 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 935593005156 Uncharacterized conserved protein [Function unknown]; Region: COG1610 935593005157 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 935593005158 stringent starvation protein A; Provisional; Region: sspA; PRK09481 935593005159 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 935593005160 C-terminal domain interface [polypeptide binding]; other site 935593005161 putative GSH binding site (G-site) [chemical binding]; other site 935593005162 dimer interface [polypeptide binding]; other site 935593005163 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 935593005164 dimer interface [polypeptide binding]; other site 935593005165 N-terminal domain interface [polypeptide binding]; other site 935593005166 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 935593005167 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 935593005168 Cadmium resistance transporter; Region: Cad; pfam03596 935593005169 ribosomal protein L31; Region: L31; TIGR00105 935593005170 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935593005171 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935593005172 catalytic residues [active] 935593005173 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 935593005174 active site 935593005175 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 935593005176 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 935593005177 anti sigma factor interaction site; other site 935593005178 regulatory phosphorylation site [posttranslational modification]; other site 935593005179 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 935593005180 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 935593005181 mce related protein; Region: MCE; pfam02470 935593005182 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 935593005183 Permease; Region: Permease; pfam02405 935593005184 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 935593005185 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 935593005186 Walker A/P-loop; other site 935593005187 ATP binding site [chemical binding]; other site 935593005188 Q-loop/lid; other site 935593005189 ABC transporter signature motif; other site 935593005190 Walker B; other site 935593005191 D-loop; other site 935593005192 H-loop/switch region; other site 935593005193 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 935593005194 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 935593005195 NAD binding site [chemical binding]; other site 935593005196 catalytic residues [active] 935593005197 substrate binding site [chemical binding]; other site 935593005198 aminodeoxychorismate synthase; Provisional; Region: PRK07508 935593005199 chorismate binding enzyme; Region: Chorismate_bind; cl10555 935593005200 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 935593005201 homodimer interface [polypeptide binding]; other site 935593005202 substrate-cofactor binding pocket; other site 935593005203 Aminotransferase class IV; Region: Aminotran_4; pfam01063 935593005204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935593005205 catalytic residue [active] 935593005206 Protein of unknown function (DUF560); Region: DUF560; pfam04575 935593005207 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 935593005208 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 935593005209 ring oligomerisation interface [polypeptide binding]; other site 935593005210 ATP/Mg binding site [chemical binding]; other site 935593005211 stacking interactions; other site 935593005212 hinge regions; other site 935593005213 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 935593005214 oligomerisation interface [polypeptide binding]; other site 935593005215 mobile loop; other site 935593005216 roof hairpin; other site 935593005217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935593005218 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 935593005219 Na2 binding site [ion binding]; other site 935593005220 putative substrate binding site 1 [chemical binding]; other site 935593005221 Na binding site 1 [ion binding]; other site 935593005222 putative substrate binding site 2 [chemical binding]; other site 935593005223 diaminopimelate decarboxylase; Region: lysA; TIGR01048 935593005224 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 935593005225 active site 935593005226 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935593005227 substrate binding site [chemical binding]; other site 935593005228 catalytic residues [active] 935593005229 dimer interface [polypeptide binding]; other site 935593005230 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 935593005231 putative iron binding site [ion binding]; other site 935593005232 conserved hypothetical integral membrane protein; Region: TIGR00698 935593005233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4316 935593005234 S-ribosylhomocysteinase; Provisional; Region: PRK02260 935593005235 DNA polymerase I; Provisional; Region: PRK05755 935593005236 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 935593005237 active site 935593005238 metal binding site 1 [ion binding]; metal-binding site 935593005239 putative 5' ssDNA interaction site; other site 935593005240 metal binding site 3; metal-binding site 935593005241 metal binding site 2 [ion binding]; metal-binding site 935593005242 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 935593005243 putative DNA binding site [nucleotide binding]; other site 935593005244 putative metal binding site [ion binding]; other site 935593005245 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 935593005246 active site 935593005247 catalytic site [active] 935593005248 substrate binding site [chemical binding]; other site 935593005249 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 935593005250 active site 935593005251 DNA binding site [nucleotide binding] 935593005252 catalytic site [active] 935593005253 Fic/DOC family; Region: Fic; pfam02661 935593005254 Transposase domain (DUF772); Region: DUF772; pfam05598 935593005255 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935593005256 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935593005257 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935593005258 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 935593005259 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 935593005260 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 935593005261 Autotransporter beta-domain; Region: Autotransporter; pfam03797 935593005262 Predicted membrane protein [Function unknown]; Region: COG5346 935593005263 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 935593005264 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 935593005265 trmE is a tRNA modification GTPase; Region: trmE; cd04164 935593005266 G1 box; other site 935593005267 GTP/Mg2+ binding site [chemical binding]; other site 935593005268 Switch I region; other site 935593005269 G2 box; other site 935593005270 Switch II region; other site 935593005271 G3 box; other site 935593005272 G4 box; other site 935593005273 G5 box; other site 935593005274 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 935593005275 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935593005276 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 935593005277 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 935593005278 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 935593005279 putative ligand binding residues [chemical binding]; other site 935593005280 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 935593005281 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935593005282 ABC-ATPase subunit interface; other site 935593005283 dimer interface [polypeptide binding]; other site 935593005284 putative PBP binding regions; other site 935593005285 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935593005286 ABC-ATPase subunit interface; other site 935593005287 dimer interface [polypeptide binding]; other site 935593005288 putative PBP binding regions; other site 935593005289 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 935593005290 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 935593005291 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935593005292 Walker A/P-loop; other site 935593005293 ATP binding site [chemical binding]; other site 935593005294 Q-loop/lid; other site 935593005295 ABC transporter signature motif; other site 935593005296 Walker B; other site 935593005297 D-loop; other site 935593005298 H-loop/switch region; other site 935593005299 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 935593005300 Nitrogen regulatory protein P-II; Region: P-II; smart00938 935593005301 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 935593005302 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 935593005303 dimerization interface [polypeptide binding]; other site 935593005304 ATP binding site [chemical binding]; other site 935593005305 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 935593005306 dimerization interface [polypeptide binding]; other site 935593005307 ATP binding site [chemical binding]; other site 935593005308 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 935593005309 putative active site [active] 935593005310 catalytic triad [active] 935593005311 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 935593005312 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 935593005313 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 935593005314 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 935593005315 Autotransporter beta-domain; Region: Autotransporter; pfam03797 935593005316 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 935593005317 MgtE intracellular N domain; Region: MgtE_N; smart00924 935593005318 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 935593005319 Divalent cation transporter; Region: MgtE; cl00786 935593005320 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 935593005321 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 935593005322 dimerization interface [polypeptide binding]; other site 935593005323 domain crossover interface; other site 935593005324 redox-dependent activation switch; other site 935593005325 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 935593005326 NlpC/P60 family; Region: NLPC_P60; pfam00877 935593005327 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 935593005328 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 935593005329 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 935593005330 heterotetramer interface [polypeptide binding]; other site 935593005331 active site pocket [active] 935593005332 cleavage site 935593005333 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 935593005334 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 935593005335 putative ion selectivity filter; other site 935593005336 putative pore gating glutamate residue; other site 935593005337 putative H+/Cl- coupling transport residue; other site 935593005338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935593005339 ATP binding site [chemical binding]; other site 935593005340 putative Mg++ binding site [ion binding]; other site 935593005341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935593005342 nucleotide binding region [chemical binding]; other site 935593005343 ATP-binding site [chemical binding]; other site 935593005344 AAA domain; Region: AAA_21; pfam13304 935593005345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935593005346 ABC transporter signature motif; other site 935593005347 Walker B; other site 935593005348 D-loop; other site 935593005349 H-loop/switch region; other site 935593005350 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 935593005351 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 935593005352 Sulfatase; Region: Sulfatase; pfam00884 935593005353 Helicase associated domain (HA2); Region: HA2; pfam04408 935593005354 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 935593005355 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 935593005356 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 935593005357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935593005358 non-specific DNA binding site [nucleotide binding]; other site 935593005359 salt bridge; other site 935593005360 sequence-specific DNA binding site [nucleotide binding]; other site 935593005361 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 935593005362 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 935593005363 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 935593005364 Helix-hairpin-helix motif; Region: HHH; pfam00633 935593005365 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 935593005366 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 935593005367 active site 935593005368 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 935593005369 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 935593005370 active site 935593005371 (T/H)XGH motif; other site 935593005372 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 935593005373 YccA-like proteins; Region: YccA_like; cd10433 935593005374 oxidative damage protection protein; Provisional; Region: PRK05408 935593005375 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 935593005376 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 935593005377 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 935593005378 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 935593005379 active site 935593005380 (T/H)XGH motif; other site 935593005381 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 935593005382 active site clefts [active] 935593005383 zinc binding site [ion binding]; other site 935593005384 dimer interface [polypeptide binding]; other site 935593005385 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 935593005386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935593005387 dimer interface [polypeptide binding]; other site 935593005388 conserved gate region; other site 935593005389 ABC-ATPase subunit interface; other site 935593005390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935593005391 dimer interface [polypeptide binding]; other site 935593005392 ABC-ATPase subunit interface; other site 935593005393 putative PBP binding loops; other site 935593005394 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 935593005395 fructuronate transporter; Provisional; Region: PRK10034; cl15264 935593005396 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 935593005397 ATP-binding site [chemical binding]; other site 935593005398 Gluconate-6-phosphate binding site [chemical binding]; other site 935593005399 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 935593005400 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 935593005401 putative active site [active] 935593005402 putative substrate binding site [chemical binding]; other site 935593005403 ATP binding site [chemical binding]; other site 935593005404 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 935593005405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593005406 S-adenosylmethionine binding site [chemical binding]; other site 935593005407 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 935593005408 aromatic amino acid transport protein; Region: araaP; TIGR00837 935593005409 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 935593005410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935593005411 active site 935593005412 motif I; other site 935593005413 motif II; other site 935593005414 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 935593005415 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 935593005416 putative acyl-acceptor binding pocket; other site 935593005417 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 935593005418 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 935593005419 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 935593005420 dimerization interface 3.5A [polypeptide binding]; other site 935593005421 active site 935593005422 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 935593005423 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 935593005424 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 935593005425 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 935593005426 trimer interface [polypeptide binding]; other site 935593005427 eyelet of channel; other site 935593005428 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 935593005429 ThiC-associated domain; Region: ThiC-associated; pfam13667 935593005430 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 935593005431 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 935593005432 nudix motif; other site 935593005433 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 935593005434 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 935593005435 Walker A/P-loop; other site 935593005436 ATP binding site [chemical binding]; other site 935593005437 Q-loop/lid; other site 935593005438 ABC transporter signature motif; other site 935593005439 Walker B; other site 935593005440 D-loop; other site 935593005441 H-loop/switch region; other site 935593005442 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 935593005443 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 935593005444 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 935593005445 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 935593005446 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 935593005447 dimerization domain swap beta strand [polypeptide binding]; other site 935593005448 regulatory protein interface [polypeptide binding]; other site 935593005449 active site 935593005450 regulatory phosphorylation site [posttranslational modification]; other site 935593005451 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 935593005452 active pocket/dimerization site; other site 935593005453 active site 935593005454 phosphorylation site [posttranslational modification] 935593005455 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935593005456 active site 935593005457 DNA ligase; Provisional; Region: PRK09125 935593005458 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 935593005459 DNA binding site [nucleotide binding] 935593005460 active site 935593005461 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 935593005462 DNA binding site [nucleotide binding] 935593005463 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 935593005464 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 935593005465 RmuC family; Region: RmuC; pfam02646 935593005466 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 935593005467 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 935593005468 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 935593005469 Qi binding site; other site 935593005470 intrachain domain interface; other site 935593005471 interchain domain interface [polypeptide binding]; other site 935593005472 heme bH binding site [chemical binding]; other site 935593005473 heme bL binding site [chemical binding]; other site 935593005474 Qo binding site; other site 935593005475 interchain domain interface [polypeptide binding]; other site 935593005476 intrachain domain interface; other site 935593005477 Qi binding site; other site 935593005478 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 935593005479 Qo binding site; other site 935593005480 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 935593005481 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 935593005482 [2Fe-2S] cluster binding site [ion binding]; other site 935593005483 Uncharacterized conserved protein [Function unknown]; Region: COG0327 935593005484 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 935593005485 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 935593005486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935593005487 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 935593005488 putative dimerization interface [polypeptide binding]; other site 935593005489 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 935593005490 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 935593005491 23S rRNA interface [nucleotide binding]; other site 935593005492 L3 interface [polypeptide binding]; other site 935593005493 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 935593005494 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 935593005495 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 935593005496 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 935593005497 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 935593005498 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 935593005499 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 935593005500 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 935593005501 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 935593005502 ATP binding site [chemical binding]; other site 935593005503 substrate interface [chemical binding]; other site 935593005504 hypothetical protein; Provisional; Region: PRK04325 935593005505 Predicted permease [General function prediction only]; Region: COG2056 935593005506 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 935593005507 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 935593005508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935593005509 S-adenosylmethionine binding site [chemical binding]; other site 935593005510 protease TldD; Provisional; Region: tldD; PRK10735 935593005511 putative hydroxymethylpyrimidine transporter CytX; Region: thia_cytX; TIGR02358 935593005512 Na binding site [ion binding]; other site 935593005513 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935593005514 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 935593005515 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 935593005516 thiamine phosphate binding site [chemical binding]; other site 935593005517 active site 935593005518 pyrophosphate binding site [ion binding]; other site 935593005519 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 935593005520 thiS-thiF/thiG interaction site; other site 935593005521 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 935593005522 ThiS interaction site; other site 935593005523 putative active site [active] 935593005524 tetramer interface [polypeptide binding]; other site 935593005525 Sporulation related domain; Region: SPOR; pfam05036 935593005526 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/pantothenate kinase; Reviewed; Region: PRK13325 935593005527 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 935593005528 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 935593005529 Pantothenate kinase type III (Bvg accessory factor family protein) [Transcription]; Region: COG1521 935593005530 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 935593005531 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 935593005532 active site 935593005533 HIGH motif; other site 935593005534 nucleotide binding site [chemical binding]; other site 935593005535 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 935593005536 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 935593005537 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 935593005538 homodimer interface [polypeptide binding]; other site 935593005539 NADP binding site [chemical binding]; other site 935593005540 substrate binding site [chemical binding]; other site 935593005541 RDD family; Region: RDD; pfam06271 935593005542 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 935593005543 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 935593005544 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 935593005545 putative active site [active] 935593005546 putative catalytic site [active] 935593005547 putative DNA binding site [nucleotide binding]; other site 935593005548 putative phosphate binding site [ion binding]; other site 935593005549 metal binding site A [ion binding]; metal-binding site 935593005550 putative AP binding site [nucleotide binding]; other site 935593005551 putative metal binding site B [ion binding]; other site 935593005552 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 935593005553 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 935593005554 active site 935593005555 HIGH motif; other site 935593005556 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 935593005557 KMSKS motif; other site 935593005558 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 935593005559 tRNA binding surface [nucleotide binding]; other site 935593005560 anticodon binding site; other site 935593005561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935593005562 AAA domain; Region: AAA_21; pfam13304 935593005563 Walker A/P-loop; other site 935593005564 ATP binding site [chemical binding]; other site 935593005565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935593005566 ABC transporter signature motif; other site 935593005567 Walker B; other site 935593005568 D-loop; other site 935593005569 H-loop/switch region; other site 935593005570 GTPase CgtA; Reviewed; Region: obgE; PRK12299 935593005571 GTP1/OBG; Region: GTP1_OBG; pfam01018 935593005572 Obg GTPase; Region: Obg; cd01898 935593005573 G1 box; other site 935593005574 GTP/Mg2+ binding site [chemical binding]; other site 935593005575 Switch I region; other site 935593005576 G2 box; other site 935593005577 G3 box; other site 935593005578 Switch II region; other site 935593005579 G4 box; other site 935593005580 G5 box; other site 935593005581 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 935593005582 Predicted methyltransferases [General function prediction only]; Region: COG0313 935593005583 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 935593005584 putative SAM binding site [chemical binding]; other site 935593005585 putative homodimer interface [polypeptide binding]; other site 935593005586 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 935593005587 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 935593005588 dimer interface [polypeptide binding]; other site 935593005589 active site 935593005590 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 935593005591 BON domain; Region: BON; pfam04972 935593005592 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 935593005593 active site 935593005594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935593005595 non-specific DNA binding site [nucleotide binding]; other site 935593005596 salt bridge; other site 935593005597 sequence-specific DNA binding site [nucleotide binding]; other site 935593005598 malate:quinone oxidoreductase; Validated; Region: PRK05257 935593005599 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 935593005600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 935593005601 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 935593005602 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 935593005603 rRNA interaction site [nucleotide binding]; other site 935593005604 S8 interaction site; other site 935593005605 putative laminin-1 binding site; other site 935593005606 elongation factor Ts; Provisional; Region: tsf; PRK09377 935593005607 UBA/TS-N domain; Region: UBA; pfam00627 935593005608 Elongation factor TS; Region: EF_TS; pfam00889 935593005609 Elongation factor TS; Region: EF_TS; pfam00889 935593005610 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 935593005611 putative nucleotide binding site [chemical binding]; other site 935593005612 uridine monophosphate binding site [chemical binding]; other site 935593005613 homohexameric interface [polypeptide binding]; other site 935593005614 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935593005615 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935593005616 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935593005617 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 935593005618 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 935593005619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935593005620 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 935593005621 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 935593005622 tandem repeat interface [polypeptide binding]; other site 935593005623 oligomer interface [polypeptide binding]; other site 935593005624 active site residues [active] 935593005625 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 935593005626 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 935593005627 putative MPT binding site; other site 935593005628 argininosuccinate synthase; Validated; Region: PRK05370 935593005629 argininosuccinate synthase; Provisional; Region: PRK13820 935593005630 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935593005631 serine/threonine transporter SstT; Provisional; Region: PRK13628 935593005632 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 935593005633 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 935593005634 Surface antigen; Region: Bac_surface_Ag; pfam01103 935593005635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 935593005636 Family of unknown function (DUF490); Region: DUF490; pfam04357 935593005637 Family of unknown function (DUF490); Region: DUF490; pfam04357 935593005638 Family of unknown function (DUF490); Region: DUF490; pfam04357 935593005639 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 935593005640 POT family; Region: PTR2; cl17359 935593005641 peptide chain release factor 2; Validated; Region: prfB; PRK00578 935593005642 This domain is found in peptide chain release factors; Region: PCRF; smart00937 935593005643 RF-1 domain; Region: RF-1; pfam00472 935593005644 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 935593005645 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 935593005646 active site 935593005647 nucleophile elbow; other site 935593005648 Predicted membrane protein [Function unknown]; Region: COG2259 935593005649 Protein of unknown function (DUF692); Region: DUF692; pfam05114 935593005650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 935593005651 RNA polymerase sigma factor; Provisional; Region: PRK12532 935593005652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935593005653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935593005654 DNA binding residues [nucleotide binding] 935593005655 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935593005656 Helix-turn-helix domain; Region: HTH_38; pfam13936 935593005657 Homeodomain-like domain; Region: HTH_32; pfam13565 935593005658 Integrase core domain; Region: rve; pfam00665 935593005659 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 935593005660 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 935593005661 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 935593005662 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 935593005663 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 935593005664 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 935593005665 Uncharacterized conserved protein [Function unknown]; Region: COG1739 935593005666 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 935593005667 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 935593005668 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 935593005669 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 935593005670 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 935593005671 Ligand binding site [chemical binding]; other site 935593005672 Electron transfer flavoprotein domain; Region: ETF; pfam01012 935593005673 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 935593005674 Isochorismatase family; Region: Isochorismatase; pfam00857 935593005675 catalytic triad [active] 935593005676 metal binding site [ion binding]; metal-binding site 935593005677 conserved cis-peptide bond; other site 935593005678 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 935593005679 homodimer interaction site [polypeptide binding]; other site 935593005680 cofactor binding site; other site 935593005681 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 935593005682 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 935593005683 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 935593005684 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 935593005685 MutS domain I; Region: MutS_I; pfam01624 935593005686 MutS domain II; Region: MutS_II; pfam05188 935593005687 MutS domain III; Region: MutS_III; pfam05192 935593005688 MutS domain V; Region: MutS_V; pfam00488 935593005689 Walker A/P-loop; other site 935593005690 ATP binding site [chemical binding]; other site 935593005691 Q-loop/lid; other site 935593005692 ABC transporter signature motif; other site 935593005693 Walker B; other site 935593005694 D-loop; other site 935593005695 H-loop/switch region; other site