-- dump date 20140619_163811 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002341564.1 218767052 906018 complement(38..358) 1 NC_003116.1 NMA0001, unknown, len: 106 aa; hypothetical protein 358 906018 NMA0001 Neisseria meningitidis Z2491 hypothetical protein YP_002341564.1 38 R 122587 CDS YP_002341565.1 218767053 906019 complement(414..2438) 1 NC_003116.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2438 nuoL 906019 nuoL Neisseria meningitidis Z2491 NADH dehydrogenase subunit L YP_002341565.1 414 R 122587 CDS YP_002341566.1 218767054 906020 complement(2487..2828) 1 NC_003116.1 NMA0003, unknown, len: 113 aa; hypothetical protein 2828 906020 NMA0003 Neisseria meningitidis Z2491 hypothetical protein YP_002341566.1 2487 R 122587 CDS YP_002341567.1 218767055 906021 complement(2952..3527) 1 NC_003116.1 NMA0004, unknown, len: 191 aa; similar to hypothetical proteins e.g. Y977_HAEIN HI0977 (191 aa),fasta scores; E(): 0; 80.5% identity in 190 aa overlap, and to proteins involved in cell cycle e.g. TR:O54679 (EMBL:AF036487) Lactococcus lactis Plasmid pNZ4000 mobilization protein (200 aa), fasta scores; E(): 0, 55.1% identity in 167 aa overlap, and FIC_ECOLI cell filamentation protein FIC (200 aa), fasta scores; E(): 0.093, 29.4% identity in 126 aa overlap; hypothetical protein 3527 906021 NMA0004 Neisseria meningitidis Z2491 hypothetical protein YP_002341567.1 2952 R 122587 CDS YP_002341568.1 218767056 906022 complement(3561..3866) 1 NC_003116.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 3866 nuoK 906022 nuoK Neisseria meningitidis Z2491 NADH dehydrogenase subunit K YP_002341568.1 3561 R 122587 CDS YP_002341569.1 218767057 906023 complement(3863..4534) 1 NC_003116.1 NMA0006, nuoJ, NADH dehydrogenase I chain J, len: 223 aa; similar to many e.g. NUOJ_RHOCA NADH dehydrogenase I chain J (EC 1.6.5.3) (202 aa), fatsa scores; E(): 9.7e-21; 41.3% identity in 201 aa overlap. Contains Pfam match to entry PF00499 oxidored_q3,NADH-ubiquinone/plastoquinone oxidoreductase chain 6; NADH dehydrogenase I subunit J 4534 906023 NMA0006 Neisseria meningitidis Z2491 NADH dehydrogenase I subunit J YP_002341569.1 3863 R 122587 CDS YP_002341570.1 218767058 906024 complement(4570..5277) 1 NC_003116.1 NMA0007, unknown, len: 235 aa; hypothetical protein 5277 906024 NMA0007 Neisseria meningitidis Z2491 hypothetical protein YP_002341570.1 4570 R 122587 CDS YP_002341571.1 218767059 906025 complement(5308..5787) 1 NC_003116.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 5787 nuoI 906025 nuoI Neisseria meningitidis Z2491 NADH dehydrogenase subunit I YP_002341571.1 5308 R 122587 CDS YP_002341572.1 218767060 906027 complement(5867..6943) 1 NC_003116.1 NMA0009, nuoH, NADH dehydrogenase I chain H, len: 358 aa; similar to many e.g. NUOH_RHOCA NADH dehydrogenase I chain H (EC 1.6.5.3) (345 aa), fasta scores; E(): 0,46.4% identity in 332 aa overlap. Contains Pfam match to entry PF00146 NADHdh, NADH dehydrogenases, and PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2; NADH dehydrogenase I subunit H 6943 906027 NMA0009 Neisseria meningitidis Z2491 NADH dehydrogenase I subunit H YP_002341572.1 5867 R 122587 CDS YP_002341573.1 218767061 906028 complement(6946..9207) 1 NC_003116.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G 9207 nuoG 906028 nuoG Neisseria meningitidis Z2491 NADH dehydrogenase subunit G YP_002341573.1 6946 R 122587 CDS YP_002341574.1 218767062 906029 complement(9489..9758) 1 NC_003116.1 NMA0011, unknown, len: 89 aa; similar to TR:O33368 (EMBL:AJ002423) N.g. hypothetical 11.4 kd protein (94 aa),fasta scores; E(): 1.1e-16; 53.0% identity in 83 aa overlap. Also similar to NMA0292, fasta scores; E(): 5.4e-19; 54.2% identity in 83 aa overlap; hypothetical protein 9758 906029 NMA0011 Neisseria meningitidis Z2491 hypothetical protein YP_002341574.1 9489 R 122587 CDS YP_002341575.1 218767063 906031 complement(10044..10481) 1 NC_003116.1 NMA0013, unknown, len: 145 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 10481 906031 NMA0013 Neisseria meningitidis Z2491 hypothetical protein YP_002341575.1 10044 R 122587 CDS YP_002341576.1 218767064 906032 complement(10481..11782) 1 NC_003116.1 NMA0014, nuoF, NADH dehydrogenase I chain F, len: 433 aa; similar to many e.g. NQO1_THETH NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3) (438 aa), fasta scores; E(): 0; 50.0% identity in 414 aa overlap, and SW:NUOF_ECOLI P31979 NADH dehydrogenase I chain F (EC 1.6.5.3) (445 aa), blastp scores Expect = 2.8e-93. Contains PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2; NADH dehydrogenase I subunit F 11782 906032 NMA0014 Neisseria meningitidis Z2491 NADH dehydrogenase I subunit F YP_002341576.1 10481 R 122587 CDS YP_002341577.1 218767065 906033 complement(12172..12645) 1 NC_003116.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 12645 nuoE 906033 nuoE Neisseria meningitidis Z2491 NADH dehydrogenase subunit E YP_002341577.1 12172 R 122587 CDS YP_002341578.1 218767066 906034 complement(12645..13901) 1 NC_003116.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 13901 nuoD 906034 nuoD Neisseria meningitidis Z2491 NADH dehydrogenase subunit D YP_002341578.1 12645 R 122587 CDS YP_002341579.1 218767067 906036 complement(13891..14484) 1 NC_003116.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 14484 nuoC 906036 nuoC Neisseria meningitidis Z2491 NADH dehydrogenase subunit C YP_002341579.1 13891 R 122587 CDS YP_002341580.1 218767068 906037 complement(14497..14979) 1 NC_003116.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 14979 nuoB 906037 nuoB Neisseria meningitidis Z2491 NADH dehydrogenase subunit B YP_002341580.1 14497 R 122587 CDS YP_002341581.1 218767069 906038 complement(14970..15326) 1 NC_003116.1 NMA0019, nuoA, NADH dehydrogenase I chain A, len: 118 aa; similar to many eg. NU3M_PLASU NADH-ubiquinone oxidoreductase chain 3 (EC 1.6.5.3) (117 aa), fastscores; E(): 8.3e-28, 55.3% identity in 114 aa overlap, and NUOA_ECOLI P33597 NADH dehydrogenase I chain A (EC 1.6.5.3) (147 aa), blastp scores; Expect = 7.1e-17; 33% identity in 112 aa overlap. Contains Pfam match to entry PF00507 oxidored_q4, NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; NADH dehydrogenase I subunit A 15326 906038 NMA0019 Neisseria meningitidis Z2491 NADH dehydrogenase I subunit A YP_002341581.1 14970 R 122587 CDS YP_002341582.1 218767070 906039 complement(15777..17261) 1 NC_003116.1 NMA0020, probable integral membrane protein, len: 494 aa; weak similarity to TR:O33279 (EMBL:AL008687) Mycobacterium tuberculosis spermidine synthase speE (523 aa), fasta scores; E(): 0.00015, 24.1% identity in 406 aa overlap. Contains several membrane spanning domains in N-terminal half; integral membrane protein 17261 906039 NMA0020 Neisseria meningitidis Z2491 integral membrane protein YP_002341582.1 15777 R 122587 CDS YP_002341583.1 218767071 906040 complement(17251..17871) 1 NC_003116.1 NMA0021, probable integral membrane protein, len: 206 aa; weak similarity to TR:CAB42042 (EMBL:AL049754) Streptomyces coelicolor spermidine synthase SCH10.33c (554 aa), fasta scores; E(): 0.0013, 25.8% identity in 194 aa overlap. Contains several membrane spanning domains; integral membrane protein 17871 906040 NMA0021 Neisseria meningitidis Z2491 integral membrane protein YP_002341583.1 17251 R 122587 CDS YP_002341584.1 218767072 906041 complement(18070..18447) 1 NC_003116.1 NMA0022, transposase for IS1016, len: 125 aa; 91.3% identity to TR:AAD31037 (EMBL:AF142582) N.g. MAFI (104 aa), and highly similar to part of TR:Q48234 (EMBL:X59756) Haemophilus influenzae insertion sequence IS1016-V6 (191 aa), fasta scores; E(): 2e-12, 67.9% identity in 53 aa overlap; IS1016 transposase 18447 906041 NMA0022 Neisseria meningitidis Z2491 IS1016 transposase YP_002341584.1 18070 R 122587 CDS YP_002341585.1 218767073 906042 18500..18829 1 NC_003116.1 NMA0023, unknown, len: 109 aa; hypothetical protein 18829 906042 NMA0023 Neisseria meningitidis Z2491 hypothetical protein YP_002341585.1 18500 D 122587 CDS YP_002341586.1 218767074 906043 18983..19198 1 NC_003116.1 NMA0024, unknown, len: 71 aa; similar to NMA0323,fasta scores; E(): 5.6e-11, 46.4% identity in 69 aa overlap; hypothetical protein 19198 906043 NMA0024 Neisseria meningitidis Z2491 hypothetical protein YP_002341586.1 18983 D 122587 CDS YP_002341587.1 218767075 906044 complement(19388..19927) 1 NC_003116.1 NMA0025, unknown, len: 179 aa; hypothetical protein 19927 906044 NMA0025 Neisseria meningitidis Z2491 hypothetical protein YP_002341587.1 19388 R 122587 CDS YP_002341588.1 218767076 906045 complement(20284..22491) 1 NC_003116.1 NMA0027, uvrD, probable DNA helicase II, len 735 aa; similar to e.g. UVRD_ECOLI DNA helicase II (EC 3.6.1.-) (720 aa), fasta scores; E(): 0, 48.0% identity in 736 aa overlap. Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase, and PS00017 ATP/GTP-binding site motif A (P-loop); DNA helicase II 22491 906045 NMA0027 Neisseria meningitidis Z2491 DNA helicase II YP_002341588.1 20284 R 122587 CDS YP_002341589.1 218767077 906046 22675..23322 1 NC_003116.1 NMA0028, unknown, len: 215 aa; similar to hypothetical proteins e.g. YBGJ_HAEIN HI1731 (213 aa),fasta scores; E(): 0, 59.0% identity in 212 aa overlap; hypothetical protein 23322 906046 NMA0028 Neisseria meningitidis Z2491 hypothetical protein YP_002341589.1 22675 D 122587 CDS YP_002341590.1 218767078 906047 23319..24248 1 NC_003116.1 NMA0029, unknown, len: 309 aa; similar to hypothetical proteins e.g. YBGK_HAEIN HI1730 (309 aa),fasta scores; E(): 0, 59.6% identity in 307 aa overlap. Also some similarity to part of DUR1_YEAST urea amidolyase (1835 aa), fasta scores; E(): 2.1e-12, 27.6% identity in 323 aa overlap; hypothetical protein 24248 906047 NMA0029 Neisseria meningitidis Z2491 hypothetical protein YP_002341590.1 23319 D 122587 CDS YP_002341591.1 218767079 906048 24235..24972 1 NC_003116.1 NMA0030, unknown, len: 245 aa; similar to hypothetical proteins e.g. YBGL_HAEIN HI1729 (257 aa),fasta scores; E(): 0, 59.6% identity in 245 aa overlap, and to LAMB_EMENI Emericella nidulans lactam utilization protein LAMB (262 aa), fasta scores; E(): 3.3e-13, 39.1% identity in 128 aa overlap; LamB/YcsF family protein 24972 906048 NMA0030 Neisseria meningitidis Z2491 LamB/YcsF family protein YP_002341591.1 24235 D 122587 CDS YP_002341592.1 218767080 906049 25101..26294 1 NC_003116.1 NMA0031, probable transmembrane transport protein,len: 397 aa; similar to many diverse transport proteins e.g. BRNQ_HAEIN branched-chain amino acid transport system carrier protein (436 aa), fasta scores; E(): 6.7e-06,23.7% identity in 371 aa overlap, and TYRP_HAEIN tyrosine-specific transport protein 1 (400 aa), fasta scores; E(): 0.25, 24.9% identity in 213 aa overlap; transmembrane transport protein 26294 906049 NMA0031 Neisseria meningitidis Z2491 transmembrane transport protein YP_002341592.1 25101 D 122587 CDS YP_002341593.1 218767081 906050 26402..27094 1 NC_003116.1 NMA0032, unknown, len: 230 aa; similar to NMA0403,fasta scores; E(): 0, 53.5% identity in 230 aa overlap; hypothetical protein 27094 906050 NMA0032 Neisseria meningitidis Z2491 hypothetical protein YP_002341593.1 26402 D 122587 CDS YP_002341594.1 218767082 906051 27359..28324 1 NC_003116.1 NMA0033, probable transposase for IS1655, len: 321 aa; similar to many e.g. TRA4_BACFR transposase for insertion sequence element IS4351 (326 aa), fasta scores; E(): 0, 41.6% identity in 310 aa overlap. Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family, score 373.60, E-value 2e-108; transposase for IS1655 28324 906051 NMA0033 Neisseria meningitidis Z2491 transposase for IS1655 YP_002341594.1 27359 D 122587 CDS YP_002341595.1 218767083 906052 complement(28626..31316) 1 NC_003116.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 31316 906052 NMA0035 Neisseria meningitidis Z2491 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_002341595.1 28626 R 122587 CDS YP_002341596.1 218767084 906053 complement(31491..31826) 1 NC_003116.1 NMA0036, unknown, len: 111 aa; hypothetical protein 31826 906053 NMA0036 Neisseria meningitidis Z2491 hypothetical protein YP_002341596.1 31491 R 122587 CDS YP_002341597.1 218767085 906054 complement(32080..32553) 1 NC_003116.1 NMA0037, unknown, len: 157 aa; hypothetical protein 32553 906054 NMA0037 Neisseria meningitidis Z2491 hypothetical protein YP_002341597.1 32080 R 122587 CDS YP_002341598.1 218767086 906055 complement(32606..32887) 1 NC_003116.1 NMA0038, unknown, len: 93 aa; highly similar to NMA2116, fasta scores; E(): 0, 88.2% identity in 93 aa overlap; hypothetical protein 32887 906055 NMA0038 Neisseria meningitidis Z2491 hypothetical protein YP_002341598.1 32606 R 122587 CDS YP_002341599.1 218767087 906056 complement(32974..33297) 1 NC_003116.1 NMA0039, unknown, len: 107 aa; hypothetical protein 33297 906056 NMA0039 Neisseria meningitidis Z2491 hypothetical protein YP_002341599.1 32974 R 122587 CDS YP_002341600.1 218767088 906059 complement(33630..34637) 1 NC_003116.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 34637 pyrD 906059 pyrD Neisseria meningitidis Z2491 dihydroorotate dehydrogenase 2 YP_002341600.1 33630 R 122587 CDS YP_002341601.1 218767089 906060 34869..35105 1 NC_003116.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 35105 acpP 906060 acpP Neisseria meningitidis Z2491 acyl carrier protein YP_002341601.1 34869 D 122587 CDS YP_002341602.1 218767090 906061 35272..36519 1 NC_003116.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 36519 fabF 906061 fabF Neisseria meningitidis Z2491 3-oxoacyl-ACP synthase YP_002341602.1 35272 D 122587 CDS YP_002341603.1 218767091 906062 complement(36762..37718) 1 NC_003116.1 NMA0046, probable transmembrane transport protein,len: 318 aa; similar to members of the SBF family e.g. TR:O34524 (EMBL:AF027868) B. subtilis transporter YOCS (321 aa), fasta scores; E(): 0, 37.7% identity in 305 aa overlap, and NTCI_HUMAN ileal sodium/bile acid cotransporter (348 aa), fasta scores; E(): 2.4e-13, 27.8% identity in 252 aa overlap; transmembrane transport protein 37718 906062 NMA0046 Neisseria meningitidis Z2491 transmembrane transport protein YP_002341603.1 36762 R 122587 CDS YP_002341604.1 218767092 906063 38144..39361 1 NC_003116.1 NMA0047, probable transmembrane transport protein,len: 405 aa; similar to e.g. YHJX_ECOLI hypothetical protein (402 aa), fasta scores; E(): 7.9e-17, 24.7% identity in 397 aa overlap, and TR:Q51330 (EMBL:U40075) Oxalobacter formigenes oxalate:formate antiport protein (418 aa), fasta scores; E(): 1.5e-16, 26.8% identity in 377 aa overlap; transmembrane transport protein 39361 906063 NMA0047 Neisseria meningitidis Z2491 transmembrane transport protein YP_002341604.1 38144 D 122587 CDS YP_002341605.1 218767093 906064 39717..40850 1 NC_003116.1 NMA0048, pglA, glycosyltransferase, len: 377 aa; almost identical to TR:O87893 (EMBL:U73942) N.m. glycosyltransferase involved in pilin glycosylation (376 aa), fasta scores; E(): 0, 98.9% identity in 377 aa overlap. Also similar to many others e.g. TR:Q53982 (EMBL:M96064) Shigella dysenteriae RFP protein (377 aa),fasta scores; E(): 0, 48.5% identity in 377 aa overlap,Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, and (g)14 tract at aa 246; glycosyltransferase 40850 906064 NMA0048 Neisseria meningitidis Z2491 glycosyltransferase YP_002341605.1 39717 D 122587 CDS YP_002341606.1 218767094 906065 complement(41790..42641) 1 NC_003116.1 NMA0049, probable RNA polymerase sigma factor, len: 283 aa; similar to many members of the sigma-54 family e.g. RP54_ALCEU RNA polymerase sigma-54 factor (493 aa),fasta scores; E(): 4.7e-11, 31.4% identity in 303 aa overlap, and RP54_ECOLI RNA polymerase sigma-54 factor (477 aa), fasta scores; E(): 0.034, 32.2% identity in 273 aa overlap. Contains PS00718 Sigma-54 factors family signature 2; RNA polymerase sigma factor 42641 906065 NMA0049 Neisseria meningitidis Z2491 RNA polymerase sigma factor YP_002341606.1 41790 R 122587 CDS YP_002341607.1 218767095 906066 42989..44503 1 NC_003116.1 NMA0050, katA, catalase, len: 504 aa; highly similar to many e.g. CATA_HAEIN catalase (EC 1.11.1.6) (508 aa), fasta scores; E(): 0, 91.7% identity in 507 aa overlap. Contains Pfam match to entry PF00199 catalase,Catalase, PS00438 Catalase proximal active site signature, and PS00437 Catalase proximal heme-ligand signature; catalase 44503 906066 NMA0050 Neisseria meningitidis Z2491 catalase YP_002341607.1 42989 D 122587 CDS YP_002341608.1 218767096 906068 44988..45554 1 NC_003116.1 NMA0052, probable integral membrane protein, len: 188 aa; similar to hypothetical proteins belonging to the UPF0059 family e.g. YEBN_ECOLI (206 aa), fasta scores; E(): 1.5e-29, 48.9% identity in 186 aa overlap; integral membrane protein 45554 906068 NMA0052 Neisseria meningitidis Z2491 integral membrane protein YP_002341608.1 44988 D 122587 CDS YP_002341609.1 218767097 906070 complement(45987..48023) 1 NC_003116.1 NMA0054, prlC, probable oligopeptidase A, len: 678 aa; similar to many e.g. OPDA_ECOLI oligopeptidase A (EC 3.4.24.70) (680 aa), fasta scores; E(): 0, 49.9% identity in 679 aa overlap. Contains Pfam match to entry PF01432 Peptidase_M3, Peptidase family M3, and PS00017 ATP/GTP-binding site motif A (P-loop); oligopeptidase A 48023 906070 NMA0054 Neisseria meningitidis Z2491 oligopeptidase A YP_002341609.1 45987 R 122587 CDS YP_002341610.1 218767098 906071 complement(48111..49097) 1 NC_003116.1 NMA0055, probable integral membrane protein, len: 328 aa; integral membrane protein 49097 906071 NMA0055 Neisseria meningitidis Z2491 integral membrane protein YP_002341610.1 48111 R 122587 CDS YP_002341611.1 218767099 906072 49253..51643 1 NC_003116.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 51643 gyrB 906072 gyrB Neisseria meningitidis Z2491 DNA gyrase subunit B YP_002341611.1 49253 D 122587 CDS YP_002341612.1 218767100 906073 51962..53281 1 NC_003116.1 NMA0057, sdaA, probable L-serine dehydratase, len: 439 aa; similar to many e.g. SDHL_STRCO L-serine dehydratase (EC 4.3.1.17) (455 aa), fasta scores; E(): 0,51.7% identity in 433 aa overlap; L-serine dehydratase 53281 906073 NMA0057 Neisseria meningitidis Z2491 L-serine dehydratase YP_002341612.1 51962 D 122587 CDS YP_002341613.1 218767101 906075 complement(54687..56663) 1 NC_003116.1 NMA0060, probable transmembrane transport protein,len; 658 aa; similar to e.g. KEFB_ECOLI glutathione-regulated potassium-efflux system protein KEFB (601 aa), fasta scores; E(): 0, 33.6% identity in 563 aa overlap, Contains PS00213 Lipocalin signature; transmembrane transport protein 56663 906075 NMA0060 Neisseria meningitidis Z2491 transmembrane transport protein YP_002341613.1 54687 R 122587 CDS YP_002341614.1 218767102 906076 56812..57651 1 NC_003116.1 NMA0061, probable ferredoxin, len: 279 aa; similar to e.g. YDGM_ECOLI ferredoxin-like protein (192 aa), fasta scores; E(): 2.7e-23, 52.9% identity in 153 aa overlap. Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains., and 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; ferredoxin 57651 906076 NMA0061 Neisseria meningitidis Z2491 ferredoxin YP_002341614.1 56812 D 122587 CDS YP_002341615.1 218767103 906077 57851..58882 1 NC_003116.1 NMA0062, gapA, glyceraldehyde 3-phosphate dehydrogenase, len: 343 aa; similar to many e.g. G3PP_ALCEU glyceraldehyde 3-phosphate dehydrogenase,plasmid (EC 1.1.1.2842) (336 aa), fasta scores; E(): 0,67.4% identity in 331 aa overlap. Contains Pfam match to entry PF00044 gpdh, glyceraldehyde 3-phosphate dehydrogenases, and PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. Also similar to gapC, NMA0246,fasta scores; E(): 0, 50.7% identity in 341 aa overlap; glyceraldehyde 3-phosphate dehydrogenase 58882 906077 NMA0062 Neisseria meningitidis Z2491 glyceraldehyde 3-phosphate dehydrogenase YP_002341615.1 57851 D 122587 CDS YP_002341616.1 218767104 906078 complement(59138..59863) 1 NC_003116.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 59863 aat 906078 aat Neisseria meningitidis Z2491 leucyl/phenylalanyl-tRNA--protein transferase YP_002341616.1 59138 R 122587 CDS YP_002341617.1 218767105 906079 complement(59933..60367) 1 NC_003116.1 NMA0064, fur, ferric uptake regulation protein,len: 144 aa; almost identical to FUR_NEIME ferric uptake regulation protein (144 aa), fasta scores; E(): 0, 99.3% identity in 144 aa overlap. Contains Pfam match to entry PF01475 FUR, Ferric uptake regulator family E-value 1.3e-68; ferric uptake regulation protein 60367 906079 NMA0064 Neisseria meningitidis Z2491 ferric uptake regulation protein YP_002341617.1 59933 R 122587 CDS YP_002341618.1 218767106 906080 60586..60963 1 NC_003116.1 NMA0065, probable lipoprotein, len: 125 aa; similar to hypothetical proteins e.g. SMPA_ECOLI small protein A (113 aa), fasta scores; E(): 1.5e-06, 39.8% identity in 103 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 60963 906080 NMA0065 Neisseria meningitidis Z2491 lipoprotein YP_002341618.1 60586 D 122587 CDS YP_002341619.1 218767107 906081 60973..61782 1 NC_003116.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 61782 dapB 906081 dapB Neisseria meningitidis Z2491 dihydrodipicolinate reductase YP_002341619.1 60973 D 122587 CDS YP_002341620.1 218767108 906082 complement(62042..62341) 1 NC_003116.1 NMA0067, unknown, len: 99 aa; hypothetical protein 62341 906082 NMA0067 Neisseria meningitidis Z2491 hypothetical protein YP_002341620.1 62042 R 122587 CDS YP_002341621.1 218767109 906084 complement(62708..63862) 1 NC_003116.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 63862 lpxB 906084 lpxB Neisseria meningitidis Z2491 lipid-A-disaccharide synthase YP_002341621.1 62708 R 122587 CDS YP_002341622.1 218767110 906085 complement(63928..64920) 1 NC_003116.1 NMA0070, rluC, probable ribosomal large subunit pseudouridine synthase C, len: 330 aa; similar to many e.g. RLUC_ECOLI ribosomal large subunit pseudouridine synthase C (EC 4.2.1.70) (319 aa), fasta scores; E(): 0,53.7% identity in 311 aa overlap. Contains Pfam match to entry PF00849 YABO, Hypothetical yabO/yceC/sfhB family, and PS01129 Hypothetical yabO/yceC/sfhB family signature; ribosomal large subunit pseudouridine synthase C 64920 906085 NMA0070 Neisseria meningitidis Z2491 ribosomal large subunit pseudouridine synthase C YP_002341622.1 63928 R 122587 CDS YP_002341623.1 218767111 906086 65414..68173 1 NC_003116.1 NMA0071, rne, probable ribonuclease E, len: 919 aa; similar to e.g. RNE_ECOLI ribonuclease E (EC 3.1.4.-) (1061 aa), fasta scores; E(): 0, 44.3% identity in 979 aa overlap. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain; ribonuclease E 68173 906086 NMA0071 Neisseria meningitidis Z2491 ribonuclease E YP_002341623.1 65414 D 122587 CDS YP_002341624.1 218767112 906087 complement(68960..69949) 1 NC_003116.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 69949 pdxA 906087 pdxA Neisseria meningitidis Z2491 4-hydroxythreonine-4-phosphate dehydrogenase YP_002341624.1 68960 R 122587 CDS YP_002341625.1 218767113 906088 70109..71536 1 NC_003116.1 NMA0073, probable amino-acid transport protein,len: 475 aa; similar to e.g. ALST_BACSU amino acid carrier protein ALST (465 aa), fasta scores; E(): 0, 49.3% identity in 469 aa overlap, and DAGA_ALTHA Na(+)-linked D-alanine glycine permease (542 aa), fasta scores; E(): 0,44.2% identity in 303 aa overlap. Contains Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family, PS00873 Sodium:alanine symporter family signature, and (cgc)5 sequence at aa 291; amino-acid transport protein 71536 906088 NMA0073 Neisseria meningitidis Z2491 amino-acid transport protein YP_002341625.1 70109 D 122587 CDS YP_002341626.1 218767114 906089 71870..73756 1 NC_003116.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 73756 gidA 906089 gidA Neisseria meningitidis Z2491 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_002341626.1 71870 D 122587 CDS YP_002341627.1 218767115 906090 73825..74409 1 NC_003116.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 74409 rnhB 906090 rnhB Neisseria meningitidis Z2491 ribonuclease HII YP_002341627.1 73825 D 122587 CDS YP_002341628.1 218767116 906091 complement(75357..76130) 1 NC_003116.1 NMA0076, parA family protein, len: 257 aa; similar to many e.g. SOJ_BACSU SOJ protein (253 aa), fasta scores; E(): 0, 55.6% identity in 248 aa overlap. Contains Pfam match to entry PF00991 ParA, ParA family ATPase; parA family protein 76130 906091 NMA0076 Neisseria meningitidis Z2491 parA family protein YP_002341628.1 75357 R 122587 CDS YP_002341629.1 218767117 906092 complement(76229..76852) 1 NC_003116.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 76852 gidB 906092 gidB Neisseria meningitidis Z2491 16S rRNA methyltransferase GidB YP_002341629.1 76229 R 122587 CDS YP_002341630.1 218767118 906093 complement(76948..77433) 1 NC_003116.1 NMA0078, probable integral membrane protein, len: 161 aa. Contains four probable transmembrane domains; integral membrane protein 77433 906093 NMA0078 Neisseria meningitidis Z2491 integral membrane protein YP_002341630.1 76948 R 122587 CDS YP_002341631.1 218767119 906094 77843..78970 1 NC_003116.1 NMA0079, probable integral membrane protein, len: 375 aa; similar to hypothetical proteins e.g. YEEA_ECOLI (352 aa), fasta scores; E(): 1.9e-20, 27.9% identity in 348 aa overlap; integral membrane protein 78970 906094 NMA0079 Neisseria meningitidis Z2491 integral membrane protein YP_002341631.1 77843 D 122587 CDS YP_002341632.1 218767120 906095 79151..79708 1 NC_003116.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 79708 frr 906095 frr Neisseria meningitidis Z2491 ribosome recycling factor YP_002341632.1 79151 D 122587 CDS YP_002341633.1 218767121 906096 79764..80510 1 NC_003116.1 NMA0081, uppS, UDP diphosphate synthase, len: 248 aa; similar to e.g. UPPS_ECOLI UDP PYROPHOSPHATE SYNTHETASE (EC 2.5.1.31) (252 aa), fasta scores; E(): 0, 51.6% identity in 246 aa overlap, and to TR:O82827 (EMBL:AB004319) Micrococcus luteus UDP diphosphate synthase (249 aa), fasta scores; E(): 0, 45.4% identity in 229 aa overlap. Contains Pfam match to entry PF01255 UPF0015, Uncharacterized protein family UPF0015, score 372.10, E-value 5.6e-108, and PS01066 Uncharacterized protein family UPF0015 signature; UDP diphosphate synthase 80510 906096 NMA0081 Neisseria meningitidis Z2491 UDP diphosphate synthase YP_002341633.1 79764 D 122587 CDS YP_002341634.1 218767122 906097 80513..81310 1 NC_003116.1 NMA0082, cdsA, probable phosphatidate cytidylyltransferase, len: 265 aa; similar to many e.g. CDSA_PSEAE phosphatidate cytidylyltransferase (EC 2.7.7.41) (271 aa), fasta scores; E(): 0, 44.2% identity in 269 aa overlap. Contains Pfam match to entry PF01148 Cytidylyltrans, Phosphatidate cytidylyltransferase, and PS01315 Phosphatidate cytidylyltransferase signature; phosphatidate cytidylyltransferase 81310 906097 NMA0082 Neisseria meningitidis Z2491 phosphatidate cytidylyltransferase YP_002341634.1 80513 D 122587 CDS YP_002341635.1 218767123 906098 81366..82550 1 NC_003116.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 82550 dxr 906098 dxr Neisseria meningitidis Z2491 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_002341635.1 81366 D 122587 CDS YP_002341636.1 218767124 906099 82585..83925 1 NC_003116.1 NMA0084, probable integral membrane protein, len: 446 aa; similar to many hypothetical proteins e.g. YAEL_ECOLI (450 aa), fasta scores; E(): 0, 38.4% identity in 456 aa overlap. Contains 2x Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF), and PS00142 Neutral zinc metallopeptidases, zinc-binding region signature; integral membrane protein 83925 906099 NMA0084 Neisseria meningitidis Z2491 integral membrane protein YP_002341636.1 82585 D 122587 CDS YP_002341637.1 218767125 906100 83982..86375 1 NC_003116.1 NMA0085, omp85, outer membrane protein OMP85, len: 797 aa; almost identical to TR:O30912 (EMBL:AF021245) N.m. strain HH outer membrane protein OMP85 (797 aa), fasta scores; E(): 0, 99.6% identity in 797 aa overlap, and similar to e.g. D152_HAEIN protective surface antigen D15 precursor (795 aa), fasta scores; E(): 0, 31.6% identity in 813 aa overlap. Contains Pfam match to entry PF01103 Bac_surface_Ag, Bacterial surface antigen, PS00017 ATP/GTP-binding site motif A (P-loop), and N-terminal signal sequence; outer membrane protein OMP85 86375 906100 NMA0085 Neisseria meningitidis Z2491 outer membrane protein OMP85 YP_002341637.1 83982 D 122587 CDS YP_002341638.1 218767126 906101 86441..86941 1 NC_003116.1 NMA0086, outer membrane protein, len: 166 aa; similar to e.g. OMPH_YEREN cationic 19 kd outer membrane protein precursor (164 aa), fasta scores; E(): 1.1e-05, 25.0% identity in 164 aa overlap, and HLPA_ECOLI histone-like protein HLP-1 precursor (161 aa), fasta scores; E(): 0.00038, 26.3% identity in 167 aa overlap. Contains N-terminal signal sequence; hypothetical protein 86941 906101 NMA0086 Neisseria meningitidis Z2491 hypothetical protein YP_002341638.1 86441 D 122587 CDS YP_002341639.1 218767127 906102 86974..88017 1 NC_003116.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 88017 lpxD 906102 lpxD Neisseria meningitidis Z2491 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_002341639.1 86974 D 122587 CDS YP_002341640.1 218767128 906103 88053..88502 1 NC_003116.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 88502 fabZ 906103 fabZ Neisseria meningitidis Z2491 (3R)-hydroxymyristoyl-ACP dehydratase YP_002341640.1 88053 D 122587 CDS YP_002341641.1 218767129 906104 88813..89493 1 NC_003116.1 NMA0089, unknown, len; 226 aa; hypothetical protein 89493 906104 NMA0089 Neisseria meningitidis Z2491 hypothetical protein YP_002341641.1 88813 D 122587 CDS YP_002341642.1 218767130 906105 89536..90312 1 NC_003116.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 90312 lpxA 906105 lpxA Neisseria meningitidis Z2491 UDP-N-acetylglucosamine acyltransferase YP_002341642.1 89536 D 122587 CDS YP_002341643.1 218767131 906106 90669..92060 1 NC_003116.1 NMA0091, probable amino-acid transporter, len: 463 aa; similar to members of the sodium:alanine symporter family e.g. Y883_HAEIN P44917 hypothetical protein HI0883 (456 aa), fasta scores; E(): 0, 52.6% identity in 454 aa overlap, and DAGA_ALTHA P30144 Na(+)-linked D-alanine glycine permease (542 aa), fasta scores; E(): 0, 36.1% identity in 540 aa overlap. Contains Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family, and PS00873 Sodium:alanine symporter family signature E-value 6e-162; amino-acid transporter 92060 906106 NMA0091 Neisseria meningitidis Z2491 amino-acid transporter YP_002341643.1 90669 D 122587 CDS YP_002341644.1 218767132 906107 92139..93395 1 NC_003116.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 93395 dadA 906107 dadA Neisseria meningitidis Z2491 D-amino acid dehydrogenase small subunit YP_002341644.1 92139 D 122587 CDS YP_002341645.1 218767133 906108 93576..94385 1 NC_003116.1 NMA0093, probable integral membrane protein, len: 269 aa; similar to hypothetical proteins e.g. YGIE_ECOLI P24198 (257 aa), fasta scores; E(): 5.8e-28, 36.8% identity in 261 aa overlap; zinc transporter ZupT 94385 906108 NMA0093 Neisseria meningitidis Z2491 zinc transporter ZupT YP_002341645.1 93576 D 122587 CDS YP_002341646.1 218767134 906109 94482..97319 1 NC_003116.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 97319 valS 906109 valS Neisseria meningitidis Z2491 valyl-tRNA synthetase YP_002341646.1 94482 D 122587 CDS YP_002341647.1 218767135 906110 97474..97629 1 NC_003116.1 NMA0095, unknown, len: 51 aa; hypothetical protein 97629 906110 NMA0095 Neisseria meningitidis Z2491 hypothetical protein YP_002341647.1 97474 D 122587 CDS YP_002341648.1 218767136 906111 complement(97690..98079) 1 NC_003116.1 NMA0096, unknown, len: 129 aa; similar to NMA1028,fasta scores; E(): 1.7e-19, 45.2% identity in 126 aa overlap, NMA1027, fasta scores; E(): 1.6e-12, 36.4% identity in 118 aa overlap, NMA1026, fasta scores; E(): 5.4e-10, 30.4% identity in 125 aa overlap, and the N-terminus of NMA1636, fasta scores; E(): 1.4e-06, 44.3% identity in 61 aa overlap; hypothetical protein 98079 906111 NMA0096 Neisseria meningitidis Z2491 hypothetical protein YP_002341648.1 97690 R 122587 CDS YP_002341649.1 218767137 906112 complement(98653..99573) 1 NC_003116.1 NMA0098, oxyR, hydrogen peroxide-inducible genes activator, len: 306 aa; similar to e.g. OXYR_ECOLI P11721 hydrogen peroxide-inducible genes activator (305 aa), fasta scores; E(): 0, 37.5% identity in 280 aa overlap. Contains Pfam match to entry PF00126 HTH_1,Bacterial regulatory helix-turn-helix protein, lysR family, and PS00044 Bacterial regulatory proteins, lysR family signature; hydrogen peroxide-inducible genes activator 99573 906112 NMA0098 Neisseria meningitidis Z2491 hydrogen peroxide-inducible genes activator YP_002341649.1 98653 R 122587 CDS YP_002341650.1 218767138 906113 complement(99577..99840) 1 NC_003116.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 99840 906113 NMA0099 Neisseria meningitidis Z2491 cell division topological specificity factor MinE YP_002341650.1 99577 R 122587 CDS YP_002341651.1 218767139 906114 complement(99844..100659) 1 NC_003116.1 NMA0100, minD, probable septum site-determining protein, len: 271 aa; highly similar to e.g. MIND_ECOLI P18197 septum site-determining protein MIND (269 aa),fasta scores; E(): 0, 73.8% identity in 271 aa overlap. Contains Pfam match to entry PF00991 ParA, ParA family ATPase, and PS00017 ATP/GTP-binding site motif A (P-loop) E-value 5.8e-05; septum site-determining protein 100659 906114 NMA0100 Neisseria meningitidis Z2491 septum site-determining protein YP_002341651.1 99844 R 122587 CDS YP_002341652.1 218767140 906115 complement(100688..101401) 1 NC_003116.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 101401 minC 906115 minC Neisseria meningitidis Z2491 septum formation inhibitor YP_002341652.1 100688 R 122587 CDS YP_002341653.1 218767141 906116 complement(101548..101916) 1 NC_003116.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 101916 rplQ 906116 rplQ Neisseria meningitidis Z2491 50S ribosomal protein L17 YP_002341653.1 101548 R 122587 CDS YP_002341654.1 218767142 906117 complement(101940..102926) 1 NC_003116.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 102926 rpoA 906117 rpoA Neisseria meningitidis Z2491 DNA-directed RNA polymerase subunit alpha YP_002341654.1 101940 R 122587 CDS YP_002341655.1 218767143 906118 complement(102952..103572) 1 NC_003116.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 103572 rpsD 906118 rpsD Neisseria meningitidis Z2491 30S ribosomal protein S4 YP_002341655.1 102952 R 122587 CDS YP_002341656.1 218767144 906119 complement(103592..103987) 1 NC_003116.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 103987 rpsK 906119 rpsK Neisseria meningitidis Z2491 30S ribosomal protein S11 YP_002341656.1 103592 R 122587 CDS YP_002341657.1 218767145 906120 complement(104007..104369) 1 NC_003116.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 104369 rpsM 906120 rpsM Neisseria meningitidis Z2491 30S ribosomal protein S13 YP_002341657.1 104007 R 122587 CDS YP_002341658.1 218767146 906121 complement(104435..104548) 1 NC_003116.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 104548 rpmJ 906121 rpmJ Neisseria meningitidis Z2491 50S ribosomal protein L36 YP_002341658.1 104435 R 122587 CDS YP_002341659.1 218767147 906122 complement(104569..104787) 1 NC_003116.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 104787 infA 906122 infA Neisseria meningitidis Z2491 translation initiation factor IF-1 YP_002341659.1 104569 R 122587 CDS YP_002341660.1 218767148 906123 complement(104792..106102) 1 NC_003116.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 106102 secY 906123 secY Neisseria meningitidis Z2491 preprotein translocase subunit SecY YP_002341660.1 104792 R 122587 CDS YP_002341661.1 218767149 906124 complement(106114..106548) 1 NC_003116.1 late assembly protein; 50S ribosomal protein L15 106548 rplO 906124 rplO Neisseria meningitidis Z2491 50S ribosomal protein L15 YP_002341661.1 106114 R 122587 CDS YP_002341662.1 218767150 906125 complement(106550..106735) 1 NC_003116.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 106735 rpmD 906125 rpmD Neisseria meningitidis Z2491 50S ribosomal protein L30 YP_002341662.1 106550 R 122587 CDS YP_002341663.1 218767151 906126 complement(106728..107246) 1 NC_003116.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 107246 rpsE 906126 rpsE Neisseria meningitidis Z2491 30S ribosomal protein S5 YP_002341663.1 106728 R 122587 CDS YP_002341664.1 218767152 906127 complement(107265..107618) 1 NC_003116.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 107618 rplR 906127 rplR Neisseria meningitidis Z2491 50S ribosomal protein L18 YP_002341664.1 107265 R 122587 CDS YP_002341665.1 218767153 906128 complement(107632..108165) 1 NC_003116.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 108165 rplF 906128 rplF Neisseria meningitidis Z2491 50S ribosomal protein L6 YP_002341665.1 107632 R 122587 CDS YP_002341666.1 218767154 906129 complement(108179..108571) 1 NC_003116.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 108571 rpsH 906129 rpsH Neisseria meningitidis Z2491 30S ribosomal protein S8 YP_002341666.1 108179 R 122587 CDS YP_002341667.1 218767155 906130 complement(108587..108892) 1 NC_003116.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 108892 rpsN 906130 rpsN Neisseria meningitidis Z2491 30S ribosomal protein S14 YP_002341667.1 108587 R 122587 CDS YP_002341668.1 218767156 906131 complement(108895..109434) 1 NC_003116.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 109434 rplE 906131 rplE Neisseria meningitidis Z2491 50S ribosomal protein L5 YP_002341668.1 108895 R 122587 CDS YP_002341669.1 218767157 906132 complement(109444..109767) 1 NC_003116.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 109767 rplX 906132 rplX Neisseria meningitidis Z2491 50S ribosomal protein L24 YP_002341669.1 109444 R 122587 CDS YP_002341670.1 218767158 906133 complement(109779..110147) 1 NC_003116.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 110147 rplN 906133 rplN Neisseria meningitidis Z2491 50S ribosomal protein L14 YP_002341670.1 109779 R 122587 CDS YP_002341671.1 218767159 906134 complement(110369..110632) 1 NC_003116.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 110632 rpsQ 906134 rpsQ Neisseria meningitidis Z2491 30S ribosomal protein S17 YP_002341671.1 110369 R 122587 CDS YP_002341672.1 218767160 906135 complement(110632..110823) 1 NC_003116.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 110823 rpmC 906135 rpmC Neisseria meningitidis Z2491 50S ribosomal protein L29 YP_002341672.1 110632 R 122587 CDS YP_002341673.1 218767161 906136 complement(110823..111239) 1 NC_003116.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 111239 rplP 906136 rplP Neisseria meningitidis Z2491 50S ribosomal protein L16 YP_002341673.1 110823 R 122587 CDS YP_002341674.1 218767162 906137 complement(111223..111915) 1 NC_003116.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 111915 rpsC 906137 rpsC Neisseria meningitidis Z2491 30S ribosomal protein S3 YP_002341674.1 111223 R 122587 CDS YP_002341675.1 218767163 906138 complement(111925..112254) 1 NC_003116.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 112254 rplV 906138 rplV Neisseria meningitidis Z2491 50S ribosomal protein L22 YP_002341675.1 111925 R 122587 CDS YP_002341676.1 218767164 906139 complement(112263..112541) 1 NC_003116.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 112541 rpsS 906139 rpsS Neisseria meningitidis Z2491 30S ribosomal protein S19 YP_002341676.1 112263 R 122587 CDS YP_002341677.1 218767165 906140 complement(112548..113381) 1 NC_003116.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 113381 rplB 906140 rplB Neisseria meningitidis Z2491 50S ribosomal protein L2 YP_002341677.1 112548 R 122587 CDS YP_002341678.1 218767166 906141 complement(113387..113707) 1 NC_003116.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 113707 rplW 906141 rplW Neisseria meningitidis Z2491 50S ribosomal protein L23 YP_002341678.1 113387 R 122587 CDS YP_002341679.1 218767167 906142 complement(113698..114318) 1 NC_003116.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 114318 rplD 906142 rplD Neisseria meningitidis Z2491 50S ribosomal protein L4 YP_002341679.1 113698 R 122587 CDS YP_002341680.1 218767168 906143 complement(114318..114962) 1 NC_003116.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 114962 rplC 906143 rplC Neisseria meningitidis Z2491 50S ribosomal protein L3 YP_002341680.1 114318 R 122587 CDS YP_002341681.1 218767169 906144 complement(115181..115864) 1 NC_003116.1 NMA0131, ATP/GTP binding protein, len: 227 aa; some similarity in ATP/GTP binding domain to TR:Q9ZL99 (EMBL:AE001499) Helicobacter pylori J99 hypothetical protein (404 aa), fasta scores; E(): 0.00018, 37.3% identity in 102 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Also similar to upstream gene NMA0132 (43.2% identity in 229 aa overlap); hypothetical protein 115864 906144 NMA0131 Neisseria meningitidis Z2491 hypothetical protein YP_002341681.1 115181 R 122587 CDS YP_002341682.1 218767170 906145 complement(115873..116928) 1 NC_003116.1 NMA0132, ATP/GTP binding protein, len: 351 aa; similar to downstream gene NMA0131 (43.2% identity in 229 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 116928 906145 NMA0132 Neisseria meningitidis Z2491 hypothetical protein YP_002341682.1 115873 R 122587 CDS YP_002341683.1 218767171 906147 complement(116903..117163) 1 NC_003116.1 NMA0132A, unknown, len: 86 aa; contains G(9) homopolymeric tract; hypothetical protein 117163 906147 NMA0132A Neisseria meningitidis Z2491 hypothetical protein YP_002341683.1 116903 R 122587 CDS YP_002341684.1 218767172 906148 complement(117216..117527) 1 NC_003116.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 117527 rpsJ 906148 rpsJ Neisseria meningitidis Z2491 30S ribosomal protein S10 YP_002341684.1 117216 R 122587 CDS YP_002341685.1 218767173 906149 complement(117545..118729) 1 NC_003116.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 118729 tufA1 906149 tufA1 Neisseria meningitidis Z2491 elongation factor Tu YP_002341685.1 117545 R 122587 CDS YP_002341686.1 218767174 906150 complement(118817..120922) 1 NC_003116.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 120922 fusA 906150 fusA Neisseria meningitidis Z2491 elongation factor G YP_002341686.1 118817 R 122587 CDS YP_002341687.1 218767175 906151 complement(120941..121411) 1 NC_003116.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 121411 rpsG 906151 rpsG Neisseria meningitidis Z2491 30S ribosomal protein S7 YP_002341687.1 120941 R 122587 CDS YP_002341688.1 218767176 906152 complement(121529..121900) 1 NC_003116.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 121900 rpsL 906152 rpsL Neisseria meningitidis Z2491 30S ribosomal protein S12 YP_002341688.1 121529 R 122587 CDS YP_002341689.1 218767177 906153 complement(122079..122228) 1 NC_003116.1 NMA0138, unknown, len: 49 aa; similar to the extreme C-terminus of Moraxella catarrhalis TR:O85087 (EMBL:AF043131) hypothetical 60.4 kd protein (538 aa),fasta scores; E(): 2.6e-07, 34.7% identity in 49 aa overlap. Also similar to the C-terminus of NMA1678 (60.9% identity in 46 aa overlap), NMA0476 (43.5% identity in 46 aa overlap), and NMA2174 (33.3% identity in 48 aa overlap); hypothetical protein 122228 906153 NMA0138 Neisseria meningitidis Z2491 hypothetical protein YP_002341689.1 122079 R 122587 CDS YP_002341690.1 218767178 906154 complement(122225..122482) 1 NC_003116.1 NMA0139, periplasmic protein, len: 85 aa; contains N-terminal signal sequence; hypothetical protein 122482 906154 NMA0139 Neisseria meningitidis Z2491 hypothetical protein YP_002341690.1 122225 R 122587 CDS YP_002341691.1 218767179 906155 complement(122531..122680) 1 NC_003116.1 NMA0140, unknown, len: 49 aa; hypothetical protein 122680 906155 NMA0140 Neisseria meningitidis Z2491 hypothetical protein YP_002341691.1 122531 R 122587 CDS YP_002341692.1 218767180 906156 complement(122773..126948) 1 NC_003116.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 126948 rpoC 906156 rpoC Neisseria meningitidis Z2491 DNA-directed RNA polymerase subunit beta' YP_002341692.1 122773 R 122587 CDS YP_002341693.1 218767181 906157 complement(127100..131278) 1 NC_003116.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 131278 rpoB 906157 rpoB Neisseria meningitidis Z2491 DNA-directed RNA polymerase subunit beta YP_002341693.1 127100 R 122587 CDS YP_002341694.1 218767182 906158 complement(131469..131840) 1 NC_003116.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 131840 rplL 906158 rplL Neisseria meningitidis Z2491 50S ribosomal protein L7/L12 YP_002341694.1 131469 R 122587 CDS YP_002341695.1 218767183 906159 complement(131898..132398) 1 NC_003116.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 132398 rplJ 906159 rplJ Neisseria meningitidis Z2491 50S ribosomal protein L10 YP_002341695.1 131898 R 122587 CDS YP_002341696.1 218767184 906160 complement(132628..133323) 1 NC_003116.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 133323 rplA 906160 rplA Neisseria meningitidis Z2491 50S ribosomal protein L1 YP_002341696.1 132628 R 122587 CDS YP_002341697.1 218767185 906161 complement(133323..133757) 1 NC_003116.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 133757 rplK 906161 rplK Neisseria meningitidis Z2491 50S ribosomal protein L11 YP_002341697.1 133323 R 122587 CDS YP_002341698.1 218767186 906162 complement(133858..134394) 1 NC_003116.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 134394 nusG 906162 nusG Neisseria meningitidis Z2491 transcription antitermination protein NusG YP_002341698.1 133858 R 122587 CDS YP_002341699.1 218767187 906163 complement(134396..134674) 1 NC_003116.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 134674 secE 906163 secE Neisseria meningitidis Z2491 preprotein translocase subunit SecE YP_002341699.1 134396 R 122587 CDS YP_002341700.1 218767188 906164 complement(134871..136055) 1 NC_003116.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 136055 tufA2 906164 tufA2 Neisseria meningitidis Z2491 elongation factor Tu YP_002341700.1 134871 R 122587 CDS YP_002341701.1 218767189 906165 complement(136472..136723) 1 NC_003116.1 NMA0150, probable ferredoxin, len: 83 aa; similar to e.g. FER_CHRVI fP00208 erredoxin (82 aa), fasta scores; E(): 1.7e-20, 70.5% identity in 78 aa overlap. Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains, and PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; ferredoxin 136723 906165 NMA0150 Neisseria meningitidis Z2491 ferredoxin YP_002341701.1 136472 R 122587 CDS YP_002341702.1 218767190 906166 complement(136846..137415) 1 NC_003116.1 NMA0151, DNA methylase, len: 189 aa; similar to hypothetical proteins containing methylase signatures e.g. YHHF_ECOLI P10120 (198 aa), fasta scores; E(): 3.1e-19, 38.2% identity in 186 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00092 N-6 Adenine-specific DNA methylases signature; DNA methylase 137415 906166 NMA0151 Neisseria meningitidis Z2491 DNA methylase YP_002341702.1 136846 R 122587 CDS YP_002341703.1 218767191 906167 complement(137504..137884) 1 NC_003116.1 NMA0153, unknown, len: 126 aa; similar to TR:Q51849 (EMBL:U39043) Pasteurella haemolytica hypothetical protein (100 aa), fasta scores; E(): 1.2e-05, 35.7% identity in 84 aa overlap. Contains Pfam match to entry PF01381 HTH_3,Helix-turn-helix; hypothetical protein 137884 906167 NMA0153 Neisseria meningitidis Z2491 hypothetical protein YP_002341703.1 137504 R 122587 CDS YP_002341704.1 218767192 906168 138003..138554 1 NC_003116.1 NMA0154, probable integral membrane protein, len: 183 aa; integral membrane protein 138554 906168 NMA0154 Neisseria meningitidis Z2491 integral membrane protein YP_002341704.1 138003 D 122587 CDS YP_002341705.1 218767193 906169 138574..139269 1 NC_003116.1 NMA0155, unknown, len: 231 aa; hypothetical protein 139269 906169 NMA0155 Neisseria meningitidis Z2491 hypothetical protein YP_002341705.1 138574 D 122587 CDS YP_002341706.1 218767194 906170 complement(139342..141648) 1 NC_003116.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity; DNA topoisomerase I 141648 topA 906170 topA Neisseria meningitidis Z2491 DNA topoisomerase I YP_002341706.1 139342 R 122587 CDS YP_002341707.1 218767195 906171 complement(141720..142181) 1 NC_003116.1 NMA0157, unknown, len: 153 aa; some similarity to SMG_ECOLI P30853 SMG protein (157 aa), fasta scores; E(): 1.1e-05, 27.3% identity in 132 aa overlap; hypothetical protein 142181 906171 NMA0157 Neisseria meningitidis Z2491 hypothetical protein YP_002341707.1 141720 R 122587 CDS YP_002341708.1 218767196 906172 complement(142207..143394) 1 NC_003116.1 NMA0158, dprA, DprA homolog, len: 395 aa; similar to SMF_HAEIN P43862 SMF protein (DNA processing chain A) thought to be involved in DNA uptake (373 aa), fasta scores; E(): 1.9e-29, 40.1% identity in 324 aa overlap, and to hypothetical proteins e.g. SMF_ECOLI P30852 SMF protein (374 aa), fasta scores; E(): 2.3e-27, 37.2% identity in 360 aa overlap; DprA-like protein 143394 906172 NMA0158 Neisseria meningitidis Z2491 DprA-like protein YP_002341708.1 142207 R 122587 CDS YP_002341709.1 218767197 906173 complement(143485..144762) 1 NC_003116.1 NMA0159, probable two-component trancriptional regulator, len: 425 aa; similar to many e.g. NTRX_AZOCA Q04849 nitrogen assimilation regulatory protein NTRX (454 aa), fasta scores; E(): 4.5e-15, 34.9% identity in 458 aa overlap, and HYDG_ECOLI P14375 transcriptional regulatory protein HYDG (441 aa), fasta scores; E(): 1.6e-14, 29.0% identity in 448 aa overlap. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain, and Pfam match to entry PF00158 sigma54, Sigma-54 transcription factors; two-component transcriptional regulator 144762 906173 NMA0159 Neisseria meningitidis Z2491 two-component transcriptional regulator YP_002341709.1 143485 R 122587 CDS YP_002341710.1 218767198 906174 complement(144755..146875) 1 NC_003116.1 NMA0160, probable two-component sensor, len: 706 aa; similar to many e.g. NTRY_AZOCA Q04850 nitrogen regulation protein NTRY (EC 2.7.3.-) (771 aa), fasta scores; E(): 0, 29.8% identity in 721 aa overlap, and ATOS_ECOLI Q06067 sensor protein ATOS (EC 2.7.3.-) (608 aa), fasta scores; E(): 2.4e-16, 25.3% identity in 439 aa overlap. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins and Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain, and four transmembrane domains; two-component sensor 146875 906174 NMA0160 Neisseria meningitidis Z2491 two-component sensor YP_002341710.1 144755 R 122587 CDS YP_002341711.1 218767199 906175 complement(146875..147474) 1 NC_003116.1 NMA0161, unknown, len: 199 aa; hypothetical protein 147474 906175 NMA0161 Neisseria meningitidis Z2491 hypothetical protein YP_002341711.1 146875 R 122587 CDS YP_002341712.1 218767200 906176 complement(147440..148699) 1 NC_003116.1 NMA0162, SUN homolog, len: 419 aa; similar to many e.g. SUN_ECOLI P36929 SUN protein (FMU protein) (429 aa),fasta scores; E(): 0, 41.2% identity in 427 aa overlap. Contains Pfam match to entry PF01189 Nol1_Nop2_Sun,NOL1/NOP2/sun family. Also similar to NMA1563 (29.9% identity in 371 aa overlap); SUN-like protein 148699 906176 NMA0162 Neisseria meningitidis Z2491 SUN-like protein YP_002341712.1 147440 R 122587 CDS YP_002341713.1 218767201 906177 complement(148778..149704) 1 NC_003116.1 NMA0163, fmt, methionyl-tRNA formyltransferase,len: 308 aa; similar to many e.g. FMT_ECOLI P23882 methionyl-tRNA formyltransferase (EC 2.1.2.9) (314 aa),fasta scores; E(): 0, 51.5% identity in 303 aa overlap. Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase; methionyl-tRNA formyltransferase 149704 906177 NMA0163 Neisseria meningitidis Z2491 methionyl-tRNA formyltransferase YP_002341713.1 148778 R 122587 CDS YP_002341714.1 218767202 906178 complement(149791..150294) 1 NC_003116.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 150294 def 906178 def Neisseria meningitidis Z2491 peptide deformylase YP_002341714.1 149791 R 122587 CDS YP_002341715.1 218767203 906179 150478..151695 1 NC_003116.1 NMA0165, probable periplasmic protein, len: 405 aa; has short segment of similarity (encompassing PFAM domain) to TR:O51302 (EMBL:AE001138) Borrelia burgdorferi hypothetical 44.2 kd protein BB0323 (377 aa), fasta scores; E(): 0.0006, 46.0% identity in 50 aa overlap, and XKDP_BACSU P54335 phage-like element PBSX protein XKDP (235 aa), fasta scores; E(): 0.0083, 50.0% identity in 40 aa overlap. Contains Pfam match to entry PF01476 PG_binding_2, peptidoglycan binding domain and N-terminal signal sequence; hypothetical protein 151695 906179 NMA0165 Neisseria meningitidis Z2491 hypothetical protein YP_002341715.1 150478 D 122587 CDS YP_002341716.1 218767204 906180 complement(151758..152423) 1 NC_003116.1 NMA0166, probable integral membrane protein, len: 211 aa; contains two membrane spanning domains near N-terminus; integral membrane protein 152423 906180 NMA0166 Neisseria meningitidis Z2491 integral membrane protein YP_002341716.1 151758 R 122587 CDS YP_002341717.1 218767205 906181 complement(152488..152946) 1 NC_003116.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase 152946 pyrI 906181 pyrI Neisseria meningitidis Z2491 aspartate carbamoyltransferase YP_002341717.1 152488 R 122587 CDS YP_002341718.1 218767206 906182 complement(152956..153876) 1 NC_003116.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 153876 pyrB 906182 pyrB Neisseria meningitidis Z2491 aspartate carbamoyltransferase YP_002341718.1 152956 R 122587 CDS YP_002341719.1 218767207 906183 154112..154954 1 NC_003116.1 NMA0169, unknown, len: 280 aa; some similarity in C-terminus to hypothetical proteins e.g. TR:O07579 (EMBL:Y14082) Bacillus subtilis hypothetical 16.4 kd protein YHDJ (142 aa), fasta scores; E(): 4.6e-06, 29.9% identity in 134 aa overlap, and PHNO_ECOLI P16691 PHNO protein (144 aa), fasta scores; E(): 0.00012, 31.9% identity in 144 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; hypothetical protein 154954 906183 NMA0169 Neisseria meningitidis Z2491 hypothetical protein YP_002341719.1 154112 D 122587 CDS YP_002341720.1 218767208 906184 154951..155109 1 NC_003116.1 NMA0170, probable lipoprotein, len: 52 aa; contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 155109 906184 NMA0170 Neisseria meningitidis Z2491 lipoprotein YP_002341720.1 154951 D 122587 CDS YP_002341721.1 218767209 906185 155236..155955 1 NC_003116.1 NMA0171, unknown, len: 239 aa; similar in part to NMA1084 (54.7% identity in 53 aa overlap), and NMA1073 (40.4% identity in 104 aa overlap); hypothetical protein 155955 906185 NMA0171 Neisseria meningitidis Z2491 hypothetical protein YP_002341721.1 155236 D 122587 CDS YP_002341722.1 218767210 906186 156030..156266 1 NC_003116.1 NMA0171A, integral membrane protein, len: 78 aa; contains two transmembrane domains; integral membrane protein 156266 906186 NMA0171A Neisseria meningitidis Z2491 integral membrane protein YP_002341722.1 156030 D 122587 CDS YP_002341723.1 218767211 906188 join(156247..156339,156339..156905) 1 NC_003116.1 NMA0173, unknown, len: 373 aa; some similarity to TR:O53037 (EMBL:U68399) Haemophilus influenzae haemocin processing protein hmcC (198 aa), fasta scores; E(): 2.6e-11, 35.5% identity in 141 aa overlap, and the trhe N-terminus of TR:O87239 (EMBL:AE001272) Lactococcus lactis plasmid pMRC01 predicted cytolysin B transport protein (708 aa), fasta scores; E(): 9.1e-05, 29.0% identity in 138 aa overlap. Also similar to NMA1066 (70.7% identity in 164 aa overlap), and NMA0767 (69.4% identity in 124 aa overlap). Frameshifted at (C)6 tract w.r.t NmC sequence. Coding sequence has been spliced to give intact translation; hypothetical protein 156905 906188 NMA0173 Neisseria meningitidis Z2491 hypothetical protein YP_002341723.1 156247 D 122587 CDS YP_002341724.1 218767212 906189 complement(157181..157732) 1 NC_003116.1 NMA0174, probable integral membrane protein, len: 183 aa; contains multiple hydrophobic transmembrane domains; integral membrane protein 157732 906189 NMA0174 Neisseria meningitidis Z2491 integral membrane protein YP_002341724.1 157181 R 122587 CDS YP_002341725.1 218767213 906192 158717..160189 1 NC_003116.1 NMA0177, pykA, pyruvate kinase, len: 490 aa; similar to many e.g. KPY2_ECOLI P14178 pyruvate kinase II (EC 2.7.1.40) (PK-2) (479 aa), fasta scores; E(): 0, 49.9% identity in 491 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase; pyruvate kinase 160189 906192 NMA0177 Neisseria meningitidis Z2491 pyruvate kinase YP_002341725.1 158717 D 122587 CDS YP_002341726.1 218767214 906193 160499..161893 1 NC_003116.1 NMA0178, probable outer membrane protein, len: 464 aa; weak similarity to several e.g. TR:Q00754 (EMBL:Q00754) Haemophilus influenzae outer membrane protein P1 precursor (449 aa), fasta scores; E(): 1.2e-07,27.6% identity in 474 aa overlap, TR:O51857 (EMBL:AF006691) Pseudomonas putida plasmid pRE4 outer membrane protein IPBH (492 aa), fasta scores; E(): 1.3e-05, 22.6% identity in 487 aa overlap, and FADL_ECOLI P10384 long-chain fatty acid transport protein precursor (448 aa), fasta scores; E(): 0.00035, 25.2% identity in 428 aa overlap. Contains N-terminal signal sequence; outer membrane protein 161893 906193 NMA0178 Neisseria meningitidis Z2491 outer membrane protein YP_002341726.1 160499 D 122587 CDS YP_002341727.1 218767215 906196 complement(163021..163218) 1 NC_003116.1 NMA0181, unknown, len: 65 aa; hypothetical protein 163218 906196 NMA0181 Neisseria meningitidis Z2491 hypothetical protein YP_002341727.1 163021 R 122587 CDS YP_002341728.1 218767216 906197 complement(163229..164245) 1 NC_003116.1 NMA0182, probable lipoprotein, len: 338 aa. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 164245 906197 NMA0182 Neisseria meningitidis Z2491 lipoprotein YP_002341728.1 163229 R 122587 CDS YP_002341729.1 218767217 906198 complement(164344..165558) 1 NC_003116.1 NMA0183, gltS, sodium/glutamate symport carrier protein, len: 404 aa; similar to many e.g. GLTS_ECOLI P19933 sodium/glutamate symport carrier protein (glutamate permease) (401 aa), fasta scores; E(): 0, 50.9% identity in 393 aa overlap; sodium/glutamate symport carrier protein 165558 906198 NMA0183 Neisseria meningitidis Z2491 sodium/glutamate symport carrier protein YP_002341729.1 164344 R 122587 CDS YP_002341730.1 218767218 906199 complement(165776..167182) 1 NC_003116.1 NMA0184, unknown, len: 468 aa; some similarity to hypothetical proteins e.g. YBEQ_ECOLI P77234 hypothetical 37.3 kd protein in leuS-gltL intergenic region (327 aa),fasta scores E(): 8.4e-07, 29.6% identity in 301 aa overlap; hypothetical protein 167182 906199 NMA0184 Neisseria meningitidis Z2491 hypothetical protein YP_002341730.1 165776 R 122587 CDS YP_002341731.1 218767219 906200 complement(167551..168810) 1 NC_003116.1 NMA0185, lipB, capsule polysaccharide modification protein, len: 419 aa; almost identical to LIPB_NEIME Q05014 capsule polysaccharide modification protein (419 aa), fasta scores; E(): 0, 99.8% identity in 419 aa overlap, and similar to e.g. KSS5_ECOLI P42218 capsule polysaccharide export protein KPSS (389 aa), fasta scores; E(): 0, 38.3% identity in 400 aa overlap; capsule polysaccharide modification protein 168810 906200 NMA0185 Neisseria meningitidis Z2491 capsule polysaccharide modification protein YP_002341731.1 167551 R 122587 CDS YP_002341732.1 218767220 906201 complement(168947..171061) 1 NC_003116.1 NMA0186, lipA, capsule polysaccharide modification protein, len: 704 aa; almost identical to, but longer than, LIPA_NEIME Q05013 capsule polysaccharide modification protein (400 aa), fasta scores; E(): 0, 97.1% identity in 383 aa overlap, and similar to e.g. KSC5_ECOLI P42217 capsule polysaccharide export protein KPSC (675 aa), fasta scores; E(): 0, 48.9% identity in 687 aa overlap. Contains PS00214 Cytosolic fatty-acid binding proteins signature; capsule polysaccharide modification protein 171061 906201 NMA0186 Neisseria meningitidis Z2491 capsule polysaccharide modification protein YP_002341732.1 168947 R 122587 CDS YP_002341733.1 218767221 906202 complement(171085..171639) 1 NC_003116.1 NMA0187, rfbC2, dTDP-4-dehydrorhamnose 3,5-epimerase, len: 184 aa; almost identical to TR:Q51155 (EMBL:L09189) N. meningitidis B1940 rfbC (333 aa), fasta scores; E(): 0, 94.5% identity in 181 aa overlap, and similar to many e.g. RFBC_NEIGO P37763 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (328 aa), fasta scores; E(): 0, 83.5% identity in 176 aa overlap. Contains Pfam match to entry PF00908 dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. Also highly similar to rfbC, NMA0206 (98.3% identity in 181 aa overlap); dTDP-D-glucose 4,6-dehydratase 171639 906202 NMA0187 Neisseria meningitidis Z2491 dTDP-D-glucose 4,6-dehydratase YP_002341733.1 171085 R 122587 CDS YP_002341734.1 218767222 906203 complement(171678..172544) 1 NC_003116.1 NMA0188, rfbA2, glucose-1-phosphate thymidylyltransferase, len: 288 aa; almost identical to RFBA_NEIME P55255 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) (288 aa), fasta scores; E(): 0, 99.3% identity in 288 aa overlap, and similar to many e.g. RFBA_NEIGO P37762 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) (288 aa), fasta scores; E(): 0, 88.5% identity in 288 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. Identical to rfbA, NMA0205; glucose-1-phosphate thymidylyltransferase 172544 906203 NMA0188 Neisseria meningitidis Z2491 glucose-1-phosphate thymidylyltransferase YP_002341734.1 171678 R 122587 CDS YP_002341735.1 218767223 906204 complement(172650..173675) 1 NC_003116.1 NMA0189, rfbB2, dTDP-glucose 4,6-dehydratase, len: 341 aa; identical to TR:AAD23919 (EMBL:AF083467) N. meningitidis MA-1 dTDP-D-glucose 4,6-dehydratase (341 aa), and similar to e.g. RFBB_NEIGO P37761 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) (346 aa), fasta scores; E(): 0, 92.4% identity in 340 aa overlap. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family. Identical to rfbB, NMA0204; dTDP-glucose 4,6-dehydratase 173675 906204 NMA0189 Neisseria meningitidis Z2491 dTDP-glucose 4,6-dehydratase YP_002341735.1 172650 R 122587 CDS YP_002341736.1 218767224 906205 complement(173791..174408) 1 NC_003116.1 NMA0190, galE2', truncated UDP-glucose 4-epimerase,len: 205 aa; almost identical to TR:Q51291 (EMBL:L20496) N. meningitidis MC58 truncated UDP-glucose 4-epimerase (galE2) (205 aa), fasta scores; E(): 0, 97.1% identity in 205 aa overlap, and similar to the N-terminus of many e.g. GALE_NEIGO Q05026 UDP-glucose 4-epimerase (EC 5.1.3.2) (338 aa), fasta scores; E(): 0, 87.9% identity in 206 aa overlap. Contains Pfam match to entry PF01370 Epimerase,NAD dependent epimerase/dehydratase family. Almost identical to the C-terminus of galE, NMA0203 (95.6% identity in 206 aa overlap); truncated UDP-glucose 4-epimerase 174408 906205 NMA0190 Neisseria meningitidis Z2491 truncated UDP-glucose 4-epimerase YP_002341736.1 173791 R 122587 CDS YP_002341737.1 218767225 906208 complement(175860..178133) 1 NC_003116.1 NMA0194, transcriptional accessory protein, len: 757 aa; similar to hypothetical proteins e.g. YHGF_ECOLI P46837 hypothetical 85.1 kd protein in greB-feoA intergenic region (773 aa), fasta scores; E(): 0, 61.7% identity in 772 aa overlap, and to TEX_BORPE Q45388 transcriptional accessory protein TEX (791 aa), fasta scores; E(): 0, 60.4% identity in 770 aa overlap. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain; transcriptional accessory protein 178133 906208 NMA0194 Neisseria meningitidis Z2491 transcriptional accessory protein YP_002341737.1 175860 R 122587 CDS YP_002341738.1 218767226 906209 complement(178197..178847) 1 NC_003116.1 NMA0195, ctrD, probable capsule polysaccharide export ATP-binding protein, len: 216 aa; almost identical to CTRD_NEIME P32016 capsule polysaccharide export ATP-binding protein (216 aa), fasta scores; E(): 0, 93.5% identity in 216 aa overlap, and similar to e.g. KST5_ECOLI P24586 polysialic acid transport ATP-binding protein KPST (224 aa), fasta scores; E(): 0, 42.3% identity in 215 aa overlap. Contains Pfam match to entry PF00005 ABC_tran,ABC transporter, PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature; capsule polysaccharide export ATP-binding protein 178847 906209 NMA0195 Neisseria meningitidis Z2491 capsule polysaccharide export ATP-binding protein YP_002341738.1 178197 R 122587 CDS YP_002341739.1 218767227 906210 complement(178844..179641) 1 NC_003116.1 NMA0196, ctrC, capsule polysaccharide export inner-membrane protein, len: 265 aa; highly similar to CTRC_NEIME P32015 capsule polysaccharide export inner-membrane protein CTRC (265 aa), fasta scores; E(): 0, 79.2% identity in 265 aa overlap, and similar to e.g. BEX2_HAEIN P19391 capsule polysaccharide export inner-membrane protein CTRC (265 aa), fasta scores; E(): 0, 67.2% identity in 265 aa overlap. Contains Pfam match to entry PF01061 ABC2_membrane, ABC-2 type transporter, and PS00890 ABC-2 type transport system integral membrane proteins signature; capsule polysaccharide export inner-membrane protein 179641 906210 NMA0196 Neisseria meningitidis Z2491 capsule polysaccharide export inner-membrane protein YP_002341739.1 178844 R 122587 CDS YP_002341740.1 218767228 906211 complement(179641..180804) 1 NC_003116.1 NMA0197, ctrB, capsule polysaccharide export inner-membrane protein, len: 387 aa; highly similar to CTRB_NEIME P32014 capsule polysaccharide export inner-membrane protein CTRB (387 aa), fasta scores; E(): 0, 84.0% identity in 387 aa overlap, and similar to e.g. BEXC_HAEIN P22930 capsule polysaccharide export inner-membrane protein BEXC (377 aa), fasta scores; E(): 0, 58.6% identity in 379 aa overlap; capsule polysaccharide export inner-membrane protein 180804 906211 NMA0197 Neisseria meningitidis Z2491 capsule polysaccharide export inner-membrane protein YP_002341740.1 179641 R 122587 CDS YP_002341741.1 218767229 906212 complement(180819..181982) 1 NC_003116.1 NMA0198, ctrA, capsule polysaccharide export outer membrane protein, len: 387 aa; almost identical to CTR2_NEIME P32758 capsule polysaccharide export outer membrane protein CTRA precursor (387 aa), fasta scores; E(): 0, 99.7% identity in 387 aa overlap, and similar to e.g. BEXD_HAEIN P22236 capsule polysaccharide export protein BEXD (394 aa), fasta scores; E(): 0, 53.8% identity in 385 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; capsule polysaccharide export outer membrane protein 181982 906212 NMA0198 Neisseria meningitidis Z2491 capsule polysaccharide export outer membrane protein YP_002341741.1 180819 R 122587 CDS YP_002341742.1 218767230 906213 182201..183319 1 NC_003116.1 NMA0199, sacA, UDP-N-acetyl-D-glucosamine 2-epimerase, len: 372 aa; almost identical to TR:O68214 (EMBL:AF019760) N. meningitidis F8229 UDP-N-acetyl-D-glucosamine 2-epimerase (372 aa), fasta scores; E(): 0, 99.7% identity in 372 aa overlap, and similar to e.g. WECB_ECOLI P27828 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) (376 aa), fasta scores; E(): 0,58.2% identity in 373 aa overlap; UDP-N-acetyl-D-glucosamine 2-epimerase 183319 906213 NMA0199 Neisseria meningitidis Z2491 UDP-N-acetyl-D-glucosamine 2-epimerase YP_002341742.1 182201 D 122587 CDS YP_002341743.1 218767231 906214 183321..184958 1 NC_003116.1 NMA0200, sacB, capsule biosynthesis protein, len: 545 aa; almost identical to TR:O68215 (EMBL:AF019760) N. meningitidis F8229 SACB (545 aa), fasta scores; E(): 0, 99.4% identity in 545 aa overlap, and similar to hypothetical proteins e.g. TR:O06628 (EMBL:Z95618) hypothetical 60.3 kd protein Rv0806c (532 aa), fasta scores; E(): 0, 35.0% identity in 380 aa overlap; capsule biosynthesis protein 184958 906214 NMA0200 Neisseria meningitidis Z2491 capsule biosynthesis protein YP_002341743.1 183321 D 122587 CDS YP_002341744.1 218767232 906215 185031..185774 1 NC_003116.1 NMA0201, sacC, capsule biosynthesis protein, len: 247 aa; identical to TR:O68216 (EMBL:AF019760) N. meningitidis F8229 SACC, (247 aa); capsule biosynthesis protein 185774 906215 NMA0201 Neisseria meningitidis Z2491 capsule biosynthesis protein YP_002341744.1 185031 D 122587 CDS YP_002341745.1 218767233 906216 185776..186639 1 NC_003116.1 NMA0202, sacD, capsule biosynthesis protein, len: 287 aa; identical to TR:O68217 (EMBL:AF019760) N. meningitidis F8229 SACD (287 aa); capsule biosynthesis protein 186639 906216 NMA0202 Neisseria meningitidis Z2491 capsule biosynthesis protein YP_002341745.1 185776 D 122587 CDS YP_002341746.1 218767234 906217 186684..187703 1 NC_003116.1 NMA0203, galE, UDP-glucose 4-epimerase, len: 339 aa; almost identical to GALE_NEIME Q59624 UDP-glucose 4-epimerase (EC 5.1.3.2) (339 aa), fasta scores; E(): 0,97.6% identity in 339 aa overlap, and similar toi many e.g. GALE_ECOLI P09147 UDP-glucose 4-epimerase (EC 5.1.3.2) (338 aa), fasta scores; E(): 0, 56.3% identity in 336 aa overlap. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family. Also similar in C-terminus to galE2' NMA0190 (95.6% identity in 206 aa overlap); UDP-glucose 4-epimerase 187703 906217 NMA0203 Neisseria meningitidis Z2491 UDP-glucose 4-epimerase YP_002341746.1 186684 D 122587 CDS YP_002341747.1 218767235 906218 187819..188844 1 NC_003116.1 NMA0204, rfbB, dTDP-glucose 4,6-dehydratase, len: 341 aa; identical to TR:AAD23919 (EMBL:AF083467) N. meningitidis MA-1 dTDP-D-glucose 4,6-dehydratase (341 aa), and similar to e.g. RFBB_NEIGO P37761 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) (346 aa), fasta scores; E(): 0, 92.4% identity in 340 aa overlap. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family. Identical to rfbB2, NMA0189; dTDP-glucose 4,6-dehydratase 188844 906218 NMA0204 Neisseria meningitidis Z2491 dTDP-glucose 4,6-dehydratase YP_002341747.1 187819 D 122587 CDS YP_002341748.1 218767236 906219 188950..189816 1 NC_003116.1 NMA0205, rfbA, glucose-1-phosphate thymidylyltransferase, len: 288 aa; almost identical to RFBA_NEIME P55255 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) (288 aa), fasta scores; E(): 0, 99.3% identity in 288 aa overlap, and similar to many e.g. RFBA_NEIGO P37762 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) (288 aa), fasta scores; E(): 0, 88.5% identity in 288 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. Identical to rfbA2, NMA0188; glucose-1-phosphate thymidylyltransferase 189816 906219 NMA0205 Neisseria meningitidis Z2491 glucose-1-phosphate thymidylyltransferase YP_002341748.1 188950 D 122587 CDS YP_002341749.1 218767237 906220 189855..190427 1 NC_003116.1 NMA0206, rfbC, dTDP-4-dehydrorhamnose 3,5-epimerase, len: 184 aa; almost identical to TR:Q51155 (EMBL:L09189) N. meningitidis B1940 rfbC (333 aa), fasta scores; E(): 0, 93.1% identity in 189 aa overlap, and similar to many e.g. RFBC_NEIGO P37763 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (328 aa), fasta scores; E(): 0, 84.2% identity in 184 aa overlap. Contains Pfam match to entry PF00908 dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase; dTDP-4-dehydrorhamnose 3,5-epimerase 190427 906220 NMA0206 Neisseria meningitidis Z2491 dTDP-4-dehydrorhamnose 3,5-epimerase YP_002341749.1 189855 D 122587 CDS YP_002341750.1 218767238 906221 complement(190470..192488) 1 NC_003116.1 NMA0207, probable integral membrane protein, len: 672 aa; similar to several hypothetical integral membrane proteins e.g. Y561_HAEIN P44016 hypothetical protein HI0561/560 (633 aa), fasta scores; E(): 0, 65.0% identity in 640 aa overlap; integral membrane protein 192488 906221 NMA0207 Neisseria meningitidis Z2491 integral membrane protein YP_002341750.1 190470 R 122587 CDS YP_002341751.1 218767239 906222 complement(192683..193804) 1 NC_003116.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 193804 906222 NMA0209 Neisseria meningitidis Z2491 chaperone protein DnaJ YP_002341751.1 192683 R 122587 CDS YP_002341752.1 218767240 906223 193851..194012 1 NC_003116.1 NMA0210, unknown, len: 53 aa; hypothetical protein 194012 906223 NMA0210 Neisseria meningitidis Z2491 hypothetical protein YP_002341752.1 193851 D 122587 CDS YP_002341753.1 218767241 906224 complement(194074..194538) 1 NC_003116.1 NMA0211, DNA transport competence protein,len: 154 aa; region of similarity to SW:P39694 (CME1_BACSU) ComE a late competence operon protein from Bacillus subtilis (205 aa) fasta scores; E(): 6.2e-07,47.6% identity in 63 aa overlap. Almost identical to TR:CAB44958 (EMBL:AJ242837) ComEA protein (fragment) from Neisseria meningitidis serogroup A strain Z2491 (170 aa) fasta scores; E(): 0, 98.7% identity in 154 aa overlap. Contains Pfam match to entry PF00633 HHH,Helix-hairpin-helix motif and membrane-spanning hydrophobic region. Identical to NMA0423, and almost identical to NMA1915 (98.7% identity in 154 aa overlap), and NMA2187 (98.7% identity in 154 aa overlap); DNA transport competence protein 194538 906224 NMA0211 Neisseria meningitidis Z2491 DNA transport competence protein YP_002341753.1 194074 R 122587 CDS YP_002341754.1 218767242 906226 complement(200338..200754) 1 NC_003116.1 NMA0213, dksA, DnaK suppressor protein,len: 138 aa; similar to e.g. DKSA_ECOLI P18274 DNAK suppressor protein (151 aa), fasta scores; opt: 376 z-score: 466.7 E(): 1.2e-18, 44.4% identity in 124 aa overlap. Contains Pfam match to entry PF01258 zf_dskA_traR, Prokaryotic dksA/traR C4-type zinc finger; DnaK suppressor protein 200754 906226 NMA0213 Neisseria meningitidis Z2491 DnaK suppressor protein YP_002341754.1 200338 R 122587 CDS YP_002341755.1 218767243 906227 complement(200901..201692) 1 NC_003116.1 NMA0215, proC, probable pyrroline-5-carboxylate reductase, len: 263 aa; similar to many e.g. PROC_HAEIN P00373 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (271 aa), fasta scores; E(): 4.8e-32, 39.3% identity in 267 aa overlap. Contains Pfam match to entry PF01089 P5CR, Delta 1-pyrroline-5-carboxylate reductase; pyrroline-5-carboxylate reductase 201692 906227 NMA0215 Neisseria meningitidis Z2491 pyrroline-5-carboxylate reductase YP_002341755.1 200901 R 122587 CDS YP_002341756.1 218767244 906228 complement(201741..202148) 1 NC_003116.1 NMA0216, probable lipoprotein, len: 135 aa. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 202148 906228 NMA0216 Neisseria meningitidis Z2491 lipoprotein YP_002341756.1 201741 R 122587 CDS YP_002341757.1 218767245 906229 complement(202148..202834) 1 NC_003116.1 NMA0217, unknown, len: 228 aa; similar to hypothetical proteins e.g. YPT5_PSEAE P24562 (230 aa),fasta scores; E(): 0, 51.5% identity in 227 aa overlap. Pfam match to entry PF01168 UPF0001, Uncharacterized protein family UPF0001; hypothetical protein 202834 906229 NMA0217 Neisseria meningitidis Z2491 hypothetical protein YP_002341757.1 202148 R 122587 CDS YP_002341758.1 218767246 906230 202954..203997 1 NC_003116.1 NMA0218, pilT, pilus retraction protein,len: 347 aa; almost identical to TR:O85741 (EMBL:AF074716) Neisseria meningitidis PILT (347 aa), fasta scores; E(): 0, 99.4% identity in 347 aa overlap, and similar to e.g. PILT_PSEAE P24559 twitching mobility protein (344 aa),fasta scores; E(): 0, 66.6% identity in 344 aa overlap. Contains Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein, PS00017 ATP/GTP-binding site motif A (P-loop), and PS00662 Bacterial type II secretion system protein E signature. Also similar to pilT2 NMA0979 (40.6% identity in 335 aa overlap), and pilU NMA0219 (33.7% identity in 335 aa overlap); pilus retraction protein 203997 906230 NMA0218 Neisseria meningitidis Z2491 pilus retraction protein YP_002341758.1 202954 D 122587 CDS YP_002341759.1 218767247 906231 204160..205386 1 NC_003116.1 NMA0219, pilU, pilT-like protein, len: 408 aa; almost identical to TR:Q06582 (EMBL:L11719) Neisseria gonorrhoeae twitching motility protein homolog (180 aa),fasta scores; E(): 0, 97.8% identity in 180 aa overlap, and similar to TR:Q51532 (EMBL:L27667) Pseudomonas aeruginosa PILU (382 aa), fasta scores; E(): 0, 44.3% identity in 368 aa overlap. Contains 2x Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein, and PS00017 ATP/GTP-binding site motif A (P-loop). Also similar to pilT2 NMA0979 (44.8% identity in 348 aa overlap) and pilT NMA0218 (33.7% identity in 335 aa overlap); twitching motility protein PilT 205386 906231 NMA0219 Neisseria meningitidis Z2491 twitching motility protein PilT YP_002341759.1 204160 D 122587 CDS YP_002341760.1 218767248 906232 205672..207822 1 NC_003116.1 NMA0220, probable integral membrane protein, len: 716 aa; simlar to several hypothetical proteins e.g. YCCS_HAEIN P44289 HI1680 (718 aa), fasta scores; E(): 0,48.2% identity in 709 aa overlap, and YCCS_ECOLI P75870 (720 aa), fasta scores; E(): 0, 36.2% identity in 704 aa overlap. Highly similar in part to YOR2_NEIGO O33369 (417 aa), fasta scores; E(): 0, 81.1% identity in 355 aa overlap. Contains two sets of six transmembrane domains between aa 1-150 and aa 370-500; integral membrane protein 207822 906232 NMA0220 Neisseria meningitidis Z2491 integral membrane protein YP_002341760.1 205672 D 122587 CDS YP_002341761.1 218767249 906233 complement(209578..210585) 1 NC_003116.1 NMA0221, probable transposase for IS1106, len: 335 aa; almost identical to many e.g. TR:CAB44967 (EMBL:AJ242841) N. meningitidis transposase for IS1106A3 (335 aa), fasta scores; E(): 0, 97.0% identity in 335 aa overlap; transposase for IS1106 210585 906233 NMA0221 Neisseria meningitidis Z2491 transposase for IS1106 YP_002341761.1 209578 R 122587 CDS YP_002341762.1 218767250 906234 211062..212519 1 NC_003116.1 NMA0222, probable peptide transporter, len: 485 aa; simlar to hypothetical proteins e.g. YCLF_BACSU P94408 (492 aa), fasta scores; E(): 0, 38.6% identity in 484 aa overlap, and to DTPT_LACLA P36574 di-/tripeptide transporter (463 aa), fasta scores; E(): 0, 36.7% identity in 463 aa overlap. Contains Pfam match to entry PF00854 PTR2, Peptide transporter family, and PS01023 PTR2 family proton/oligopeptide symporters signature 2; peptide transporter 212519 906234 NMA0222 Neisseria meningitidis Z2491 peptide transporter YP_002341762.1 211062 D 122587 CDS YP_002341763.1 218767251 906236 complement(213431..214534) 1 NC_003116.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 214534 prfB 906236 prfB Neisseria meningitidis Z2491 peptide chain release factor 2 YP_002341763.1 213431 R 122587 CDS YP_002341764.1 218767252 906237 complement(214637..215539) 1 NC_003116.1 NMA0225, lipoprotein, len: 300 aa; similar to hypothetical proteins e.g. YCHK_ECOLI (314 aa), fasta scores; E(): 1.2e-17, 36.6% identity in 194 aa overlap. Contains Pfam match to entry PF01173 UPF0028,Uncharacterized protein family UPF0028, N-terminal signal sequence, and PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 215539 906237 NMA0225 Neisseria meningitidis Z2491 lipoprotein YP_002341764.1 214637 R 122587 CDS YP_002341765.1 218767253 906238 215872..216321 1 NC_003116.1 NMA0226, probable integral membrane protein, len: 149 aa; similar to YG02_HAEIN P44270 HI1602 (151 aa),fasta scores; E(): 1.5e-32, 58.8% identity in 136 aa overlap. Also similar to NMA2196 (34.1% identity in 129 aa overlap); integral membrane protein 216321 906238 NMA0226 Neisseria meningitidis Z2491 integral membrane protein YP_002341765.1 215872 D 122587 CDS YP_002341766.1 218767254 906239 216395..216703 1 NC_003116.1 NMA0227, probable periplasmic protein, len: 102 aa; similar to YG01_HAEIN P44269 HI1601 precursor (95 aa),fasta scores; E(): 3.9e-09, 48.0% identity in 100 aa overlap. Contains N-terminal signal sequence; hypothetical protein 216703 906239 NMA0227 Neisseria meningitidis Z2491 hypothetical protein YP_002341766.1 216395 D 122587 CDS YP_002341767.1 218767255 906240 216819..217661 1 NC_003116.1 NMA0228, unknown, len: 280 aa; similar to YG00_HAEIN P44268 HI1600 (317 aa), fasta scores; E(): 0,66.0% identity in 294 aa overlap; hypothetical protein 217661 906240 NMA0228 Neisseria meningitidis Z2491 hypothetical protein YP_002341767.1 216819 D 122587 CDS YP_002341768.1 218767256 906241 217651..218397 1 NC_003116.1 NMA0229, unknown, len: 248 aa; similar to YF99_HAEIN P44267 HI1599 (238 aa), fasta scores; E(): 1.3e-24, 36.1% identity in 227 aa overlap; hypothetical protein 218397 906241 NMA0229 Neisseria meningitidis Z2491 hypothetical protein YP_002341768.1 217651 D 122587 CDS YP_002341769.1 218767257 906242 218419..219006 1 NC_003116.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 219006 906242 NMA0230 Neisseria meningitidis Z2491 RNA polymerase sigma factor YP_002341769.1 218419 D 122587 CDS YP_002341770.1 218767258 906243 219450..219872 1 NC_003116.1 NMA0233, probable lipoprotein, len: 140 aa. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 219872 906243 NMA0233 Neisseria meningitidis Z2491 lipoprotein YP_002341770.1 219450 D 122587 CDS YP_002341771.1 218767259 906246 complement(222047..222649) 1 NC_003116.1 NMA0237, unknown, len: 200 aa; similar to hypothetical proteins e.g. YRDC_ECOLI P45748 (190 aa),fasta scores; E(): 4.4e-20, 41.7% identity in 168 aa overlap. Contains Pfam match to entry PF01300 Sua5_yciO_yrdC, SUA5/yciO/yrdC family, PS01147 SUA5/yciO/yrdC family signature, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; hypothetical protein 222649 906246 NMA0237 Neisseria meningitidis Z2491 hypothetical protein YP_002341771.1 222047 R 122587 CDS YP_002341772.1 218767260 906247 complement(222683..223954) 1 NC_003116.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 223954 purD 906247 purD Neisseria meningitidis Z2491 phosphoribosylamine--glycine ligase YP_002341772.1 222683 R 122587 CDS YP_002341773.1 218767261 906248 224111..224428 1 NC_003116.1 NMA0239, unknowwn, len: 105 aa; hypothetical protein 224428 906248 NMA0239 Neisseria meningitidis Z2491 hypothetical protein YP_002341773.1 224111 D 122587 CDS YP_002341774.1 218767262 906249 complement(224480..225091) 1 NC_003116.1 NMA0240, unknown, len: 203 aa; similar to hypothetical proteins e.g. YIGZ_ECOLI P27862 (205 aa),fasta scores; E(): 6.5e-16, 36.3% identity in 160 aa overlap. Contains Pfam match to entry PF01205 UPF0029,Uncharacterized protein family UPF0029, and PS00910 Uncharacterized protein family UPF0029 signature; hypothetical protein 225091 906249 NMA0240 Neisseria meningitidis Z2491 hypothetical protein YP_002341774.1 224480 R 122587 CDS YP_002341775.1 218767263 906250 complement(225154..226089) 1 NC_003116.1 NMA0241, etfA, electron transfer flavoprotein alpha-subunit, len: 311 aa; highly similar to many e.g. ETFA_BRAJA P53573 electron transfer flavoprotein alpha-subunit (314 aa), fasta scores; E(): 0, 59.4% identity in 310 aa overlap, and ETFA_HUMAN P13804 electron transfer flavoprotein alpha-subunit (333 aa), fasta scores; E(): 0, 55.1% identity in 312 aa overlap. Contains Pfam match to entry PF00766 ETF_alpha, Electron transfer flavoprotein alpha subunit; electron transfer flavoprotein subunit alpha 226089 906250 NMA0241 Neisseria meningitidis Z2491 electron transfer flavoprotein subunit alpha YP_002341775.1 225154 R 122587 CDS YP_002341776.1 218767264 906251 complement(226100..226849) 1 NC_003116.1 NMA0242, etfB, flaX, electron transfer flavoprotein beta-subunit, len: 249 aa; almost identical to TR:Q51129 (EMBL:U40862) N. meningitidis FLAX (249 aa), fasta scores; E(): 0,97.2% identity in 249 aa overlap, and highly similar to e.g. ETFB_BRAJA P53575 electron transfer flavoprotein beta-subunit (249 aa), fasta scores; E(): 0,62.7% identity in 249 aa overlap, and ETFB_HUMAN P38117 electron transfer flavoprotein beta-subunit (255 aa),fasta scores; E(): 0, 55.6% identity in 252 aa overlap. Contains Pfam match to entry PF01012 ETF_beta, Electron transfer flavoprotein beta subunit; electron transfer flavoprotein subunit beta 226849 906251 NMA0242 Neisseria meningitidis Z2491 electron transfer flavoprotein subunit beta YP_002341776.1 226100 R 122587 CDS YP_002341777.1 218767265 906252 complement(227075..228043) 1 NC_003116.1 NMA0243, rfaC, lipopolysaccharide heptosyltransferase I, len: 322 aa; almost identical to TR:Q51122 (EMBL:U35454) N. meningitidis heptosyltransferase I (322 aa), fasta scores; E(): 0,97.8% identity in 322 aa overlap, and similar to e.g. RFAC_ECOLI P24173 lipopolysaccharide heptosyltransferase-1 (319 aa), fasta scores; E(): 0, 40.8% identity in 287 aa overlap. Contains Pfam match to entry PF01075 Heptosyltranf, Heptosyltransferase; lipopolysaccharide heptosyltransferase I 228043 906252 NMA0243 Neisseria meningitidis Z2491 lipopolysaccharide heptosyltransferase I YP_002341777.1 227075 R 122587 CDS YP_002341778.1 218767266 906253 complement(228080..228715) 1 NC_003116.1 NMA0244, pncA, probable nicotinamidase, len: 211 aa; similar to e.g. PNCA_ECOLI P21369 pyrazinamidase/nicotinamidase [includes: pyrazinamidase (EC 3.5.1.-) (PZASE); nicotinamidase (EC 3.5.1.19) (nicotine deamidase)] (213 aa), fasta scores; E(): 7e-09,32.5% identity in 212 aa overlap; nicotinamidase 228715 906253 NMA0244 Neisseria meningitidis Z2491 nicotinamidase YP_002341778.1 228080 R 122587 CDS YP_002341779.1 218767267 906254 228830..229510 1 NC_003116.1 NMA0245, unknown, len: 226 aa; similar to hypothetical proteins e.g. YAEB_ECOLI P28634 (235 aa),fasta scores; opt: 578 z-score: 695.1 E(): 2.3e-31 41.8% identity in 232 aa overlap; hypothetical protein 229510 906254 NMA0245 Neisseria meningitidis Z2491 hypothetical protein YP_002341779.1 228830 D 122587 CDS YP_002341780.1 218767268 906255 complement(229768..230772) 1 NC_003116.1 NMA0246, gapC, glyceraldehyde 3-phosphate dehydrogenase C, len: 334 aa; highly similar to many e.g. G3P_CLOPA Q59309 glyceraldehyde 3-phosphate dehydrogenase (EC 1.1.1.2842) (334 aa), fasta scores; E(): 0, 75.9% identity in 328 aa overlap, and G3P3_ECOLI P33898 glyceraldehyde 3-phosphate dehydrogenase C (EC 1.1.1.2842) (332 aa), fasta scores; E(): 0, 57.1% identity in 331 aa overlap. Contains Pfam match to entry PF00044 gpdh,glyceraldehyde 3-phosphate dehydrogenases, and PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. Also similar to gapA, NMA0062 (50.7% identity in 341 aa overlap); glyceraldehyde 3-phosphate dehydrogenase C 230772 906255 NMA0246 Neisseria meningitidis Z2491 glyceraldehyde 3-phosphate dehydrogenase C YP_002341780.1 229768 R 122587 CDS YP_002341781.1 218767269 906256 231216..233810 1 NC_003116.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 233810 mutS 906256 mutS Neisseria meningitidis Z2491 DNA mismatch repair protein MutS YP_002341781.1 231216 D 122587 CDS YP_002341782.1 218767270 906257 complement(233934..234425) 1 NC_003116.1 NMA0248, acetyltransferase, len: 163 aa; contains weak similarity to predicted acetyltransferases e.g. TR:Q50708 (EMBL:Z77165) M. tuberculosis ribosomal-protein-alanine acetyltransferase (158 aa),fasta scores; E(): 0.00045, 30.5% identity in 154 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; acetyltransferase 234425 906257 NMA0248 Neisseria meningitidis Z2491 acetyltransferase YP_002341782.1 233934 R 122587 CDS YP_002341783.1 218767271 906258 complement(234429..234770) 1 NC_003116.1 NMA0249, probable periplasmic protein, len: 113 aa; contains probable N-terminal signal sequence and coiled-coil domain around aa 50; hypothetical protein 234770 906258 NMA0249 Neisseria meningitidis Z2491 hypothetical protein YP_002341783.1 234429 R 122587 CDS YP_002341784.1 218767272 906259 complement(234845..236239) 1 NC_003116.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 236239 gltX 906259 gltX Neisseria meningitidis Z2491 glutamyl-tRNA synthetase YP_002341784.1 234845 R 122587 CDS YP_002341785.1 218767273 906260 complement(236355..237011) 1 NC_003116.1 NMA0251, probable periplasmic protein, len: 218 aa; some similarity to e.g. TR:O07474 (EMBL:U61158) Staphylococcus gallinarum GDMH protein involved in antibiotic gallidermin secretion (330 aa), fasta scores; E(): 1.5e-06, 29.5% identity in 129 aa overlap, and SANA_ECOLI P33017 SANA protein involved in the barrier function of the cell envelope (239 aa), fasta scores; E(): 0.00013, 23.6% identity in 212 aa overlap. Contains N-terminal signal sequence; hypothetical protein 237011 906260 NMA0251 Neisseria meningitidis Z2491 hypothetical protein YP_002341785.1 236355 R 122587 CDS YP_002341786.1 218767274 906261 complement(237008..237361) 1 NC_003116.1 NMA0252, probable oxidoreductase, len: 117 aa; similar to YFGD_ECOLI P76569 hypothetical protein (119 aa), fasta scores; E(): 1.2e-23, 53.9% identity in 115 aa overlap, and to e.g. ARC2_ECOLI P52147 arsenate reductase (141 aa), fasta scores; E(): 8.3e-12, 35.9% identity in 117 aa overlap; oxidoreductase 237361 906261 NMA0252 Neisseria meningitidis Z2491 oxidoreductase YP_002341786.1 237008 R 122587 CDS YP_002341787.1 218767275 906262 237485..237967 1 NC_003116.1 NMA0253, probable periplasmic thiredoxin, len: 160 aa; similar to e.g. TLPA_BRAJA P43221 thiol:disulfide interchange protein TLPA (221 aa), fasta scores; E(): 7.4e-08, 30.7% identity in 153 aa overlap; periplasmic thiredoxin 237967 906262 NMA0253 Neisseria meningitidis Z2491 periplasmic thiredoxin YP_002341787.1 237485 D 122587 CDS YP_002341788.1 218767276 906263 238162..238812 1 NC_003116.1 NMA0254, ftsE, probable ABC transporter ATP-binding protein, len: 305 aa; similar to e.g. FTSE_ECOLI P10115 cell division ATP-binding protein FTSE (222 aa), fasta scores; E(): 0, 50.2% identity in 215 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter; ABC transporter ATP-binding protein 238812 906263 NMA0254 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002341788.1 238162 D 122587 CDS YP_002341789.1 218767277 906264 238809..239726 1 NC_003116.1 NMA0255, ftsX, probable ABC transporter integral membrane protein, len: 305 aa; similar to e.g. FTSX_ECOLI P10122 cell division protein FTSX (352 aa), fasta scores; E(): 2.6e-20, 29.5% identity in 288 aa overlap; ABC transporter 239726 906264 NMA0255 Neisseria meningitidis Z2491 ABC transporter YP_002341789.1 238809 D 122587 CDS YP_002341790.1 218767278 906265 239818..240066 1 NC_003116.1 NMA0256, unknown, len: 82 aa; similar to hypothetical proteins e.g. YV22_SYNY3 P73055 SSR3122 (85 aa), fasta scores; E(): 1.5e-06, 35.7% identity in 84 aa overlap, and YRBA_ECOLI P43781 (84 aa), fasta scores; E(): 6e-06, 31.5% identity in 73 aa overlap; hypothetical protein 240066 906265 NMA0256 Neisseria meningitidis Z2491 hypothetical protein YP_002341790.1 239818 D 122587 CDS YP_002341791.1 218767279 906266 complement(240133..241311) 1 NC_003116.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 241311 pgk 906266 pgk Neisseria meningitidis Z2491 phosphoglycerate kinase YP_002341791.1 240133 R 122587 CDS YP_002341792.1 218767280 906267 complement(241392..242645) 1 NC_003116.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 242645 murA 906267 murA Neisseria meningitidis Z2491 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002341792.1 241392 R 122587 CDS YP_002341793.1 218767281 906268 complement(243161..244135) 1 NC_003116.1 NMA0259, probable transmembrane transport protein,len: 324 aa; similar to hypothetical membrane proteins e.g. YGJT_ECOLI P42601 (321 aa), fasta scores; E(): 0,55.5% identity in 301 aa overlap, and to TERC_ALCSP P18780 tellurium resistance protein TERC (346 aa), fasta scores; E(): 1.4e-11, 34.8% identity in 345 aa overlap; transmembrane transport protein 244135 906268 NMA0259 Neisseria meningitidis Z2491 transmembrane transport protein YP_002341793.1 243161 R 122587 CDS YP_002341794.1 218767282 906269 complement(244168..244617) 1 NC_003116.1 NMA0260, probable integral membrane protein, len: 149 aa; similar to TR:O26032 (EMBL:AE000648) Helicabacter pylori HP1502 (145 aa), fasta scores; E(): 2.3e-09, 29.5% identity in 149 aa overlap; integral membrane protein 244617 906269 NMA0260 Neisseria meningitidis Z2491 integral membrane protein YP_002341794.1 244168 R 122587 CDS YP_002341795.1 218767283 906270 complement(244658..245929) 1 NC_003116.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 245929 kdtA 906270 kdtA Neisseria meningitidis Z2491 3-deoxy-D-manno-octulosonic-acid transferase YP_002341795.1 244658 R 122587 CDS YP_002341796.1 218767284 906271 complement(245992..247440) 1 NC_003116.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 247440 gnd 906271 gnd Neisseria meningitidis Z2491 6-phosphogluconate dehydrogenase YP_002341796.1 245992 R 122587 CDS YP_002341797.1 218767285 906272 complement(248626..249549) 1 NC_003116.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 249549 lpxC 906272 lpxC Neisseria meningitidis Z2491 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_002341797.1 248626 R 122587 CDS YP_002341798.1 218767286 906273 complement(250476..250988) 1 NC_003116.1 NMA0264, pilE, fimbrial protein precursor (pilin),len: 170 aa; highly similar to e.g. FMM1_NEIME P05431 fimbrial protein precursor (pilin) (167 aa), fasta scores; E(): 0, 85.2% identity in 169 aa overlap. Contains Pfam match to entry PF00114 pilin, and PS00409 Prokaryotic N-terminal methylation site; fimbrial protein (pilin) 250988 906273 NMA0264 Neisseria meningitidis Z2491 fimbrial protein (pilin) YP_002341798.1 250476 R 122587 CDS YP_002341799.1 218767287 906281 complement(256488..256850) 1 NC_003116.1 NMA0272, pilS8, pilin, partial CDS, len: 113 aa; highly similar to e.g. FMD3_NEIGO Q00046 fimbrial protein MS11-D3A precursor (L-pilin) (180 aa), fasta scores; E(): 1.3e-16, 63.0% identity in 81 aa overlap; truncated pilin 256850 906281 NMA0272 Neisseria meningitidis Z2491 truncated pilin YP_002341799.1 256488 R 122587 CDS YP_002341800.1 218767288 906282 complement(256879..257208) 1 NC_003116.1 NMA0273, fbp, peptidyl-prolyl cis-trans isomerase,len: 109aa; almost identical to FKBP_NEIME P25138 FK506-binding protein (peptidyl-prolyl cis-trans isomerase) (PPIASE) (EC 5.2.1.8) (109 aa), fasta scores; E(): 0, 97.2% identity in 109 aa overlap. Contains Pfam match to entry PF00254 FKBP, FKBP-type peptidyl-prolyl cis-trans isomerases, PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1, and PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. Also similar to NMA1756 (45.9% identity in 98 aa overlap); peptidyl-prolyl cis-trans isomerase 257208 906282 NMA0273 Neisseria meningitidis Z2491 peptidyl-prolyl cis-trans isomerase YP_002341800.1 256879 R 122587 CDS YP_002341801.1 218767289 906283 257779..258732 1 NC_003116.1 NMA0274, glycerate dehydrogenase, len: 322 aa; similar to DHGY_METEX Q59516 glycerate dehydrogenase (EC 1.1.1.29) (313 aa), fasta scores; E(): 0, 47.8% identity in 316 aa overlap, and to e.g. SERA_RAT O08651 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) (533 aa),fasta scores; E(): 2.4e-26, 31.4% identity in 322 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH,D-isomer specific 2-hydroxyacid dehydrogenases, PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2, and PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3; glycerate dehydrogenase 258732 906283 NMA0274 Neisseria meningitidis Z2491 glycerate dehydrogenase YP_002341801.1 257779 D 122587 CDS YP_002341802.1 218767290 906284 complement(258807..260864) 1 NC_003116.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 260864 metG 906284 metG Neisseria meningitidis Z2491 methionyl-tRNA synthetase YP_002341802.1 258807 R 122587 CDS YP_002341803.1 218767291 906285 complement(260980..262818) 1 NC_003116.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 262818 glmS 906285 glmS Neisseria meningitidis Z2491 glucosamine--fructose-6-phosphate aminotransferase YP_002341803.1 260980 R 122587 CDS YP_002341804.1 218767292 906286 263100..263618 1 NC_003116.1 NMA0277, probable lipoprotein, len: 172 aa. Contains N-terminal signal sequence, and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 263618 906286 NMA0277 Neisseria meningitidis Z2491 lipoprotein YP_002341804.1 263100 D 122587 CDS YP_002341805.1 218767293 906287 complement(264036..265361) 1 NC_003116.1 NMA0279, probable membrane-bound lytic murein transglycosylase, len: 441 aa; similar to MLTA_ECOLI P46885 membrane-bound lytic murein transglycosylase A precursor (EC 3.2.1.-) (365 aa), fasta scores; E(): 1.4e-16, 27.7% identity in 441 aa overlap. Contains N-terminal signal sequence, and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; membrane-bound lytic murein transglycosylase 265361 906287 NMA0279 Neisseria meningitidis Z2491 membrane-bound lytic murein transglycosylase YP_002341805.1 264036 R 122587 CDS YP_002341806.1 218767294 906288 265572..266411 1 NC_003116.1 NMA0280, probable integral membrane protein, len: 279 aa; similar to hypothetical membrane proteins e.g. YCDN_ECOLI P75901 (276 aa), fasta scores; E(): 0, 51.5% identity in 274 aa overlap; integral membrane protein 266411 906288 NMA0280 Neisseria meningitidis Z2491 integral membrane protein YP_002341806.1 265572 D 122587 CDS YP_002341807.1 218767295 906289 266408..267574 1 NC_003116.1 NMA0281, probable lipoprotein, len: 388 aa; similar to hypothetical proteins e.g. YCDO_ECOLI P75902 (375 aa),fasta scores; E(): 0, 62.8% identity in 360 aa overlap. Contains N-terminal signals sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; hypothetical protein 267574 906289 NMA0281 Neisseria meningitidis Z2491 hypothetical protein YP_002341807.1 266408 D 122587 CDS YP_002341808.1 218767296 906290 267838..269103 1 NC_003116.1 NMA0282, periplasmic protein, len: 421 aa; similar to e.g. YCDB_ECOLI P31545 hypothetical lipoprotein (423 aa), fasta scores; E(): 0, 49.5% identity in 424 aa overlap. Contains N-terminal signal sequence; hypothetical protein 269103 906290 NMA0282 Neisseria meningitidis Z2491 hypothetical protein YP_002341808.1 267838 D 122587 CDS YP_002341809.1 218767297 906291 complement(269175..269504) 1 NC_003116.1 NMA0283, phnA, PhnA protein NMB_orthologue, len: 109 aa; similar to many e.g. PHNA_ECOLI P16680 PHNA protein (111 aa), fasta scores; E(): 4.7e-25, 68.2% identity in 110 aa overlap; PhnA protein NMB_orthologue 269504 906291 NMA0283 Neisseria meningitidis Z2491 PhnA protein NMB_orthologue YP_002341809.1 269175 R 122587 CDS YP_002341810.1 218767298 906292 complement(269581..270951) 1 NC_003116.1 NMA0284, glmU, UDP-N-acetylglucosamine pyrophosphorylase, len: 456 aa; similar to amny e.g. GLMU_NEIGO Q50986 UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (456 aa), fasta scores; E(): 0, 91.7% identity in 456 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase, and 2x Pfam match to entry PF00132 hexapep,Bacterial transferase hexapeptide (four repeats); UDP-N-acetylglucosamine pyrophosphorylase 270951 906292 NMA0284 Neisseria meningitidis Z2491 UDP-N-acetylglucosamine pyrophosphorylase YP_002341810.1 269581 R 122587 CDS YP_002341811.1 218767299 906295 272044..273045 1 NC_003116.1 NMA0287, tbpA, probable thiamin-binding periplasmic protein, len: 333 aa; similar to e.g. TBPA_ECOLI P31550 thiamin-binding periplasmic protein precursor (327 aa),fasta scores; E(): 3.3e-21, 30.9% identity in 333 aa overlap. Contains N-terminal signal sequence; thiamin-binding periplasmic protein 273045 906295 NMA0287 Neisseria meningitidis Z2491 thiamin-binding periplasmic protein YP_002341811.1 272044 D 122587 CDS YP_002341812.1 218767300 906296 273139..273987 1 NC_003116.1 NMA0288, probable integral membrane protein, len: 282 aa; similar to hypothetical integral membrane proteins e.g. YGGB_ECOLI P11666 (286 aa), fasta scores; E(): 7.2e-31, 34.3% identity in 268 aa overlap. Contains Pfam match to entry PF00924 UPF0003, Uncharacterized protein family UPF0003; integral membrane protein 273987 906296 NMA0288 Neisseria meningitidis Z2491 integral membrane protein YP_002341812.1 273139 D 122587 CDS YP_002341813.1 218767301 906297 274013..274498 1 NC_003116.1 NMA0289, unknown, len: 161 aa; similar to hypothetical proteins e.g. YGAD_ENTAG P51967 (164 aa),fasta scores; E(): 3.4e-26, 55.9% identity in 152 aa overlap, and to the C-terminus of CINA_STRPN P54184 competence-damage protein (418 aa), fasta scores; E(): 7e-11, 37.1% identity in 151 aa overlap; hypothetical protein 274498 906297 NMA0289 Neisseria meningitidis Z2491 hypothetical protein YP_002341813.1 274013 D 122587 CDS YP_002341814.1 218767302 906298 complement(274600..276168) 1 NC_003116.1 NMA0290, pilB, probable peptide methionine sulfoxide reductase, len: 522 aa; almost identical to PMSR_NEIGO P14930 peptide methionine sulfoxide reductase (521 aa), fasta scores; E(): 0, 88.0% identity in 527 aa overlap, and similar in C-terminus to e.g. PMSR_STRPN P35593 peptide methionine sulfoxide reductase (312 aa),fasta scores; E(): 4.9e-31, 51.7% identity in 317 aa overlap, and in N-terminus to e.g. THIO_STRCO P52230 thioredoxin (110 aa), blastp scores; Expect = 0.0028, 30% identity in 107 aa overlap; trifunctional thioredoxin/methionine sulfoxide reductase A/B protein 276168 906298 NMA0290 Neisseria meningitidis Z2491 trifunctional thioredoxin/methionine sulfoxide reductase A/B protein YP_002341814.1 274600 R 122587 CDS YP_002341815.1 218767303 906299 276314..277579 1 NC_003116.1 NMA0291, pilA, ftsY, probable signal recognition particle protein, len: 421 aa; almost identical to PILA_NEIME O30391 probable signal recognition particle protein (421 aa), fasta scores; E(): 0, 97.9% identity in 421 aa overlap, and highly similar to e.g. FTSY_ECOLI P10121 cell division protein FTSY (497 aa), fasta scores; E(): 0, 47.6% identity in 412 aa overlap. Contains Pfam match to entry PF00448 SRP54, SRP54-type protein, PS00017 ATP/GTP-binding site motif A (P-loop), and PS00300 SRP54-type proteins GTP-binding domain signature; signal recognition particle protein 277579 906299 NMA0291 Neisseria meningitidis Z2491 signal recognition particle protein YP_002341815.1 276314 D 122587 CDS YP_002341816.1 218767304 906300 278168..278452 1 NC_003116.1 NMA0292, unknown, len: aa; almost identical to TR:O33368 (EMBL:AJ002423) N. gonorrhoeae hypothetical 11.4 kd protein (94 aa), fasta scores; E(): 0, 96.8% identity in 94 aa overlap. Also similar to NMA0011, fasta scores; E(): 5.4e-19; 54.2% identity in 83 aa overlap; hypothetical protein 278452 906300 NMA0292 Neisseria meningitidis Z2491 hypothetical protein YP_002341816.1 278168 D 122587 CDS YP_002341817.1 218767305 906301 join(279084..279167,279167..282250) 1 NC_003116.1 NMA0293, pilC2, pilus-associated protein,pseudogene, len: 30 aa; N-terminus identical to the N-terminus of TR:O05925 (EMBL:Y13021) N. meningitidis FAM20 pilC2 (1048 aa). C-terminus highly similar to the C-terminus of TR:O05925 (EMBL:Y13021) N. meningitidis FAM20 pilC2 (6248 bp), fasta scores; E(): 0, 75.2% identity in 1036 aa overlap. Contains a (g)11 tract at aa 27 that, if variable, would allow translation as an intact CDS. Also similar to NMA0609, pilC1 (intact) (90% identity in 30 aa overlap and 82.8% identity in 1050 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Coding sequence has been spliced to give intact translation; hypothetical protein 282250 906301 NMA0293 Neisseria meningitidis Z2491 hypothetical protein YP_002341817.1 279084 D 122587 CDS YP_002341818.1 218767306 906302 complement(283684..287799) 1 NC_003116.1 NMA0295, probable periplasmic protein, len: 1371 aa; some similarity to YTFN_ECOLI P39321 hypothetical 136.8 kd protein (1259 aa), fasta scores; E(): 2.2e-17,21.6% identity in 1403 aa overlap. Contains N-terminal signal sequence; hypothetical protein 287799 906302 NMA0295 Neisseria meningitidis Z2491 hypothetical protein YP_002341818.1 283684 R 122587 CDS YP_002341819.1 218767307 906303 complement(287908..289755) 1 NC_003116.1 NMA0296, probable outer membrane protein, len: 615 aa; some similarity to e.g. YTFM_ECOLI P39320 hypothetical protein (577 aa), fasta scores; E(): 2.3e-20, 23.4% identity in 569 aa overlap, and to TR:P95359 (EMBL:U81959) N. gonorrhoeae outer membrane protein omp85 (792 aa),fasta scores; E(): 0.0031, 23.2% identity in 595 aa overlap; outer membrane protein 289755 906303 NMA0296 Neisseria meningitidis Z2491 outer membrane protein YP_002341819.1 287908 R 122587 CDS YP_002341820.1 218767308 906304 290320..291549 1 NC_003116.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 291549 906304 NMA0298 Neisseria meningitidis Z2491 serine/threonine transporter SstT YP_002341820.1 290320 D 122587 CDS YP_002341821.1 218767309 906305 291661..293154 1 NC_003116.1 NMA0299, probable periplasmic protein, len: 497 aa; contains N-terminal signal sequence; hypothetical protein 293154 906305 NMA0299 Neisseria meningitidis Z2491 hypothetical protein YP_002341821.1 291661 D 122587 CDS YP_002341822.1 218767310 906306 complement(293229..293444) 1 NC_003116.1 NMA0300, probable integral membrane protein, len: 71 aa; integral membrane protein 293444 906306 NMA0300 Neisseria meningitidis Z2491 integral membrane protein YP_002341822.1 293229 R 122587 CDS YP_002341823.1 218767311 906307 complement(293437..293652) 1 NC_003116.1 NMA0301, unknonwn, len: 71 aa; hypothetical protein 293652 906307 NMA0301 Neisseria meningitidis Z2491 hypothetical protein YP_002341823.1 293437 R 122587 CDS YP_002341824.1 218767312 906308 complement(293859..295202) 1 NC_003116.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 295202 argG 906308 argG Neisseria meningitidis Z2491 argininosuccinate synthase YP_002341824.1 293859 R 122587 CDS YP_002341825.1 218767313 906309 295327..296127 1 NC_003116.1 NMA0304, unknown, len: 266 aa; similar to hypothetical proteins e.g. TR:AAD42399 (EMBL:AF157493) Zymomonas mobilis hypothetical competence-damage protein ZM10ORF4 (253 aa), fasta scores; E(): 8.4e-12, 31.1% identity in 209 aa overlap, and weakly simar to the N-terminus of e.g. CINA_BACSU P46323 competence-damage protein (416 aa), fasta scores; E(): 0.00012, 25.6% identity in 254 aa overlap; hypothetical protein 296127 906309 NMA0304 Neisseria meningitidis Z2491 hypothetical protein YP_002341825.1 295327 D 122587 CDS YP_002341826.1 218767314 906310 296167..297153 1 NC_003116.1 NMA0305, probable protease, len: 328 aa; similar to part of e.g. SPPA_SYNY3 P73689 protease IV homolog (610 aa), fasta scores; E(): 1.4e-14, 32.7% identity in 211 aa overlap, and SPPA_ECOLI P08395 protease IV (618 aa), fasta scores; E(): 2.5e-10, 29.2% identity in 271 aa overlap. Contains Pfam match to entry PF01343 Peptidase_U7,Peptidase family U7; protease 297153 906310 NMA0305 Neisseria meningitidis Z2491 protease YP_002341826.1 296167 D 122587 CDS YP_002341827.1 218767315 906314 complement(298110..298484) 1 NC_003116.1 NMA0307, unknown, len: 124 aa; similar to upstream gene NMA0320 (45.6% identity in 125 aa overlap); hypothetical protein 298484 906314 NMA0307 Neisseria meningitidis Z2491 hypothetical protein YP_002341827.1 298110 R 122587 CDS YP_002341828.1 218767316 7163863 complement(298481..298609) 1 NC_003116.1 hypothetical protein 298609 7163863 NMA0307A Neisseria meningitidis Z2491 hypothetical protein YP_002341828.1 298481 R 122587 CDS YP_002341829.1 218767317 906315 complement(298657..299013) 1 NC_003116.1 NMA0308, unknown, len: 118 aa; hypothetical protein 299013 906315 NMA0308 Neisseria meningitidis Z2491 hypothetical protein YP_002341829.1 298657 R 122587 CDS YP_002341830.1 218767318 906320 complement(299156..299500) 1 NC_003116.1 NMA0310, unknown, len: 114 aa; hypothetical protein 299500 906320 NMA0310 Neisseria meningitidis Z2491 hypothetical protein YP_002341830.1 299156 R 122587 CDS YP_002341831.1 218767319 906321 complement(299659..300060) 1 NC_003116.1 NMA0311, unknown, len: 133 aa; similar to NMA2120 (32.8% identity in 128 aa overlap); hypothetical protein 300060 906321 NMA0311 Neisseria meningitidis Z2491 hypothetical protein YP_002341831.1 299659 R 122587 CDS YP_002341832.1 218767320 906323 complement(300863..301180) 1 NC_003116.1 NMA0314, unknown, len: 105 aa; hypothetical protein 301180 906323 NMA0314 Neisseria meningitidis Z2491 hypothetical protein YP_002341832.1 300863 R 122587 CDS YP_002341833.1 218767321 906324 complement(301872..302174) 1 NC_003116.1 NMA0316, unknown, len 100 aa; hypothetical protein 302174 906324 NMA0316 Neisseria meningitidis Z2491 hypothetical protein YP_002341833.1 301872 R 122587 CDS YP_002341834.1 218767322 906325 complement(302197..302466) 1 NC_003116.1 NMA0317, unknown, len: 89 aa; hypothetical protein 302466 906325 NMA0317 Neisseria meningitidis Z2491 hypothetical protein YP_002341834.1 302197 R 122587 CDS YP_002341835.1 218767323 906326 complement(302487..302693) 1 NC_003116.1 NMA0318, unknown, len: 68 aa; hypothetical protein 302693 906326 NMA0318 Neisseria meningitidis Z2491 hypothetical protein YP_002341835.1 302487 R 122587 CDS YP_002341836.1 218767324 906327 complement(303514..303885) 1 NC_003116.1 NMA0320, unknown, len: 123 aa. Similar to NMA0307 (45.6% identity in 125 aa overlap); hypothetical protein 303885 906327 NMA0320 Neisseria meningitidis Z2491 hypothetical protein YP_002341836.1 303514 R 122587 CDS YP_002341837.1 218767325 906328 complement(303882..304088) 1 NC_003116.1 NMA0321, unknown, len: 68 aa; hypothetical protein 304088 906328 NMA0321 Neisseria meningitidis Z2491 hypothetical protein YP_002341837.1 303882 R 122587 CDS YP_002341838.1 218767326 906329 complement(304091..304252) 1 NC_003116.1 NMA0322, unknown, len: 53 aa; hypothetical protein 304252 906329 NMA0322 Neisseria meningitidis Z2491 hypothetical protein YP_002341838.1 304091 R 122587 CDS YP_002341839.1 218767327 906330 complement(304265..304471) 1 NC_003116.1 NMA0323, unknown, len: 68 aa. Similar to NMA0024 (46.4% identity in 69 aa overlap); hypothetical protein 304471 906330 NMA0323 Neisseria meningitidis Z2491 hypothetical protein YP_002341839.1 304265 R 122587 CDS YP_002341840.1 218767328 906331 complement(304481..305929) 1 NC_003116.1 NMA0324, mafB, adhesin, len: 492 aa; almost identical to TR:AAD31039 (EMBL:AF142582) Neisseria gonorrhoeae MS11 adhesin MAFB (509 aa), fasta scores; E(): 0, 72.6% identity in 503 aa overlap, but varying in the C-terminus. An identical sequence to the C-terminus is present in NMA0319 (mafB'). NMA0319, NMA0315, NMA0313 and NMA0309 contain perfect direct repeats from this gene, and may represent alternative C-termini. Contains N-terminal signal sequence. Also similar to NMA2113 (31.4% identity in 500 aa overlap), and NMA0853 (33.5% identity in 376 aa overlap); adhesin 305929 906331 NMA0324 Neisseria meningitidis Z2491 adhesin YP_002341840.1 304481 R 122587 CDS YP_002341841.1 218767329 906332 complement(305969..306931) 1 NC_003116.1 NMA0325, mafA, adhesin, len: 320 aa; almost identical to TR:AAD31038 (EMBL:AF142582) Neisseria gonorrhoeae MS11 adhesin MAFA (320 aa), fastaa scores; E(): 0, 98.4% identity in 320 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; adhesin 306931 906332 NMA0325 Neisseria meningitidis Z2491 adhesin YP_002341841.1 305969 R 122587 CDS YP_002341842.1 218767330 906333 complement(307114..307833) 1 NC_003116.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 307833 pyrH 906333 pyrH Neisseria meningitidis Z2491 uridylate kinase YP_002341842.1 307114 R 122587 CDS YP_002341843.1 218767331 906334 complement(308156..309010) 1 NC_003116.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 309010 tsf 906334 tsf Neisseria meningitidis Z2491 elongation factor Ts YP_002341843.1 308156 R 122587 CDS YP_002341844.1 218767332 906335 complement(309139..309867) 1 NC_003116.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 309867 rpsB 906335 rpsB Neisseria meningitidis Z2491 30S ribosomal protein S2 YP_002341844.1 309139 R 122587 CDS YP_002341845.1 218767333 906336 complement(310068..310277) 1 NC_003116.1 NMA0329, integral membrane protein, len: 69 aa; integral membrane protein 310277 906336 NMA0329 Neisseria meningitidis Z2491 integral membrane protein YP_002341845.1 310068 R 122587 CDS YP_002341846.1 218767334 906337 310355..310936 1 NC_003116.1 NMA0330, unknown, len: 193 aa; similar to hypothetical proteins e.g. YGFA_HAEIN P44905 hypothetical protein HI0858 (187 aa), fasta scores; E(): 5e-11, 27.8% identity in 194 aa overlap, and to e.g. FTHC_HUMAN P49914 5-formyltetrahydrofolate cyclo-ligase (202 aa), fasta scores; E(): 6.7e-07, 24.1% identity in 191 aa overlap; hypothetical protein 310936 906337 NMA0330 Neisseria meningitidis Z2491 hypothetical protein YP_002341846.1 310355 D 122587 CDS YP_002341847.1 218767335 906338 310997..311587 1 NC_003116.1 NMA0331, unknown, len: 196 aa; similar to hypothetical proteins e.g. TR:O54394 (EMBL:U81516) hypothetical 24.4 kd protein (216 aa), fasta scores; E(): 4.2e-19, 37.2% identity in 199 aa overlap; hypothetical protein 311587 906338 NMA0331 Neisseria meningitidis Z2491 hypothetical protein YP_002341847.1 310997 D 122587 CDS YP_002341848.1 218767336 906339 312124..313590 1 NC_003116.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 313590 mqo 906339 mqo Neisseria meningitidis Z2491 malate:quinone oxidoreductase YP_002341848.1 312124 D 122587 CDS YP_002341849.1 218767337 906340 complement(313778..314338) 1 NC_003116.1 NMA0335, adhesin component, len: 186 aa; similar to TR:P94741 (EMBL:D78153) Eikenella corrodens component protein of adhesin complex (226 aa), fasta scores; E(): 3.9e-08, 43.9% identity in 98 aa overlap; adhesin component 314338 906340 NMA0335 Neisseria meningitidis Z2491 adhesin component YP_002341849.1 313778 R 122587 CDS YP_002341850.1 218767338 906341 complement(314390..314689) 1 NC_003116.1 NMA0336, unknown, len: 99 aa; hypothetical protein 314689 906341 NMA0336 Neisseria meningitidis Z2491 hypothetical protein YP_002341850.1 314390 R 122587 CDS YP_002341851.1 218767339 906342 complement(314844..315623) 1 NC_003116.1 NMA0337, map, methionine aminopeptidase, len: 259 aa; similar to many e.g. AMPM_ECOLI P07906 methionine aminopeptidase (EC 3.4.11.18) (264 aa), fasta scores; E(): 0, 56.4% identity in 257 aa overlap. Contains Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24, and PS00680 Methionine aminopeptidase subfamily 1 signature; methionine aminopeptidase 315623 906342 NMA0337 Neisseria meningitidis Z2491 methionine aminopeptidase YP_002341851.1 314844 R 122587 CDS YP_002341852.1 218767340 906343 complement(315663..316256) 1 NC_003116.1 NMA0338, probable periplasmic protein, len: 197 aa; contains N-terminal signal sequence and P-,E-rich C-terminal region; hypothetical protein 316256 906343 NMA0338 Neisseria meningitidis Z2491 hypothetical protein YP_002341852.1 315663 R 122587 CDS YP_002341853.1 218767341 906344 complement(316321..316929) 1 NC_003116.1 NMA0339, probable lipoprotein, len: 202 aa; similar to hypothetical proteins e.g. YRAP_ECOLI P45467 (191 aa),fasta scores; E(): 4.8e-14, 35.0% identity in 183 aa overlap, and to HLY2_ACTPL P46028 Actinobacillus pleuropneumoniae 21 KD hemolysin precursor (194 aa), fasta scores; E(): 9.2e-10, 32.3% identity in 164 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 316929 906344 NMA0339 Neisseria meningitidis Z2491 lipoprotein YP_002341853.1 316321 R 122587 CDS YP_002341854.1 218767342 906345 complement(316993..317586) 1 NC_003116.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 317586 gmhA 906345 gmhA Neisseria meningitidis Z2491 phosphoheptose isomerase YP_002341854.1 316993 R 122587 CDS YP_002341855.1 218767343 906346 complement(317591..317938) 1 NC_003116.1 NMA0341, unknown, len: 115 aa; similar to hypothetical proteins e.g. YRAN_ECOLI P45465 (131 aa),fasta scores; E(): 7.4e-11, 37.7% identity in 114 aa overlap; hypothetical protein 317938 906346 NMA0341 Neisseria meningitidis Z2491 hypothetical protein YP_002341855.1 317591 R 122587 CDS YP_002341856.1 218767344 906347 317991..318866 1 NC_003116.1 NMA0342, unknown, len: 291 aa; similar to many hypothetical proteins e.g. YRAL_ECOLI P45528 (286 aa),fasta scores; E(): 0, 44.4% identity in 284 aa overlap. Contains Pfam match to entry PF00590 TP_methylase,Tetrapyrrole (Corrin/Porphyrin) Methylases; hypothetical protein 318866 906347 NMA0342 Neisseria meningitidis Z2491 hypothetical protein YP_002341856.1 317991 D 122587 CDS YP_002341857.1 218767345 906348 complement(318901..319305) 1 NC_003116.1 NMA0343, cybB, probable cytochrome B561, len: 134 aa; similar to e.g. C561_ECOLI P08732 cytochrome B561 (176 aa), fasta scores; E(): 0.00015, 30.6% identity in 134 aa overlap; cytochrome B561 319305 906348 NMA0343 Neisseria meningitidis Z2491 cytochrome B561 YP_002341857.1 318901 R 122587 CDS YP_002341858.1 218767346 906351 320559..321713 1 NC_003116.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 321713 obgE 906351 obgE Neisseria meningitidis Z2491 GTPase ObgE YP_002341858.1 320559 D 122587 CDS YP_002341859.1 218767347 906352 321796..322845 1 NC_003116.1 NMA0346, probable ATP-binding protein, len: 349 aa; Also similar to NMA0935 (28.7% identity in 338 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); ATP-binding protein 322845 906352 NMA0346 Neisseria meningitidis Z2491 ATP-binding protein YP_002341859.1 321796 D 122587 CDS YP_002341860.1 218767348 906353 322855..324954 1 NC_003116.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 324954 cysS 906353 cysS Neisseria meningitidis Z2491 cysteinyl-tRNA synthetase YP_002341860.1 322855 D 122587 CDS YP_002341861.1 218767349 906354 325037..325816 1 NC_003116.1 NMA0348, nuclease, len: 259 aa; similar to EXOA_BACSU P37454 exodeoxyribonuclease (252 aa), fasta scores; E(): 0, 39.0% identity in 251 aa overlap, and TR:Q51380 (EMBL:U38241) Pseudomonas aeruginosa catabolite repression control protein (259 aa), fasta scores; E(): 0,37.3% identity in 255 aa overlap, and APE1_HUMAN P27695 DNA-(apurinic or apyrimidinic site) lyase (317 aa), fasta scores; E(): 0, 35.8% identity in 254 aa overlap. Contains Pfam match to entry PF01260 AP_endonucleas1, AP endonuclease family 1, and PS00726 AP endonucleases family 1 signature 1. Also similar to NMA2086, xthA (29.5% identity in 268 aa overlap); nuclease 325816 906354 NMA0348 Neisseria meningitidis Z2491 nuclease YP_002341861.1 325037 D 122587 CDS YP_002341862.1 218767350 906355 325803..326147 1 NC_003116.1 NMA0349, probable integral membrane protein, len: 114 aa; contains three transmembrane domain; integral membrane protein 326147 906355 NMA0349 Neisseria meningitidis Z2491 integral membrane protein YP_002341862.1 325803 D 122587 CDS YP_002341863.1 218767351 906356 326157..326687 1 NC_003116.1 NMA0350, unknown, len: 176 aa; hypothetical protein 326687 906356 NMA0350 Neisseria meningitidis Z2491 hypothetical protein YP_002341863.1 326157 D 122587 CDS YP_002341864.1 218767352 906357 complement(326780..327895) 1 NC_003116.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 327895 906357 NMA0351 Neisseria meningitidis Z2491 aspartate-semialdehyde dehydrogenase YP_002341864.1 326780 R 122587 CDS YP_002341865.1 218767353 906358 328071..328652 1 NC_003116.1 NMA0353, probable integral membrane protein, len: 193 aa; some similarity to YF60_HAEIN P44253 hypothetical protein HI1560 (156 aa), fasta scores; E(): 0.0012, 28.1% identity in 128 aa overlap; integral membrane protein 328652 906358 NMA0353 Neisseria meningitidis Z2491 integral membrane protein YP_002341865.1 328071 D 122587 CDS YP_002341866.1 218767354 906359 complement(328714..329568) 1 NC_003116.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 329568 906359 NMA0354 Neisseria meningitidis Z2491 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002341866.1 328714 R 122587 CDS YP_002341867.1 218767355 906360 330283..330789 1 NC_003116.1 NMA0356, transferase, len: 168 aa; similar to e.g. TR:Q43999 (EMBL:U07639) Alcaligenes eutrophus H16 autotrophic growth (aut) gene (164 aa), fasta scores; E(): 0, 59.4% identity in 160 aa overlap, and to C-terminus of RFAE_ECOLI P76658 ADP-heptose synthase (477 aa), fasta scores; E(): 1.4e-22, 50.4% identity in 137 aa overlap. Contains Pfam match to entry PF01467 Cytidylyltransf,Cytidylyltransferase; transferase 330789 906360 NMA0356 Neisseria meningitidis Z2491 transferase YP_002341867.1 330283 D 122587 CDS YP_002341868.1 218767356 906361 330786..332564 1 NC_003116.1 activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins and catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; bifunctional biotin--[acetyl-CoA-carboxylase] ligase/pantothenate kinase 332564 birA 906361 birA Neisseria meningitidis Z2491 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/pantothenate kinase YP_002341868.1 330786 D 122587 CDS YP_002341869.1 218767357 906362 332677..333501 1 NC_003116.1 NMA0358, probable periplasmic protein, len: 274 aa. Contains N-terminal signal sequence and probable coiled-coil domain from approx aa 70-100; hypothetical protein 333501 906362 NMA0358 Neisseria meningitidis Z2491 hypothetical protein YP_002341869.1 332677 D 122587 CDS YP_002341870.1 218767358 906364 complement(334264..335052) 1 NC_003116.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 335052 thiG 906364 thiG Neisseria meningitidis Z2491 thiazole synthase YP_002341870.1 334264 R 122587 CDS YP_002341871.1 218767359 906365 complement(335266..335460) 1 NC_003116.1 NMA0362, unknown, len: 64 aa; hypothetical protein 335460 906365 NMA0362 Neisseria meningitidis Z2491 hypothetical protein YP_002341871.1 335266 R 122587 CDS YP_002341872.1 218767360 906366 complement(335882..336499) 1 NC_003116.1 NMA0363, thiE, thiamin-phosphate pyrophosphorylase,len: 205 aa; THIE_ECOLI P30137 thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) (211 aa), fasta scores; E(): 1.3e-32, 52.1% identity in 188 aa overlap. Contains PS00012 Phosphopantetheine attachment site; thiamin-phosphate pyrophosphorylase 336499 906366 NMA0363 Neisseria meningitidis Z2491 thiamin-phosphate pyrophosphorylase YP_002341872.1 335882 R 122587 CDS YP_002341873.1 218767361 906367 complement(336520..337620) 1 NC_003116.1 NMA0364, probable oxidoreductase, len: 366 aa; similar to e.g. TR:O34292 (EMBL:AF004408) Rhizobium etli amino acid oxidase flavoprotein thiO (327 aa),fasta scores; E(): 1.1e-23, 36.2% identity in 351 aa overlap, and GLOX_BACSU O31616 glycine oxidase (369 aa),fasta scores; E(): 1e-08, 24.3% identity in 350 aa overlap; oxidoreductase 337620 906367 NMA0364 Neisseria meningitidis Z2491 oxidoreductase YP_002341873.1 336520 R 122587 CDS YP_002341874.1 218767362 906368 complement(337526..338839) 1 NC_003116.1 NMA0365, probable permease, len: 437 aa; similar to e.g. CODB_ECOLI P25525 cytosine permease (419 aa), fasta scores; E(): 3.8e-14, 26.0% identity in 369 aa overlap; permease 338839 906368 NMA0365 Neisseria meningitidis Z2491 permease YP_002341874.1 337526 R 122587 CDS YP_002341875.1 218767363 906370 339126..340568 1 NC_003116.1 NMA0367, tldD, TLDD protein homolog, len: 480 aa; TLDD_ECOLI P46473 TLDD protein (481 aa), fasta scores; E(): 0, 53.9% identity in 477 aa overlap; TLDD protein-like protein 340568 906370 NMA0367 Neisseria meningitidis Z2491 TLDD protein-like protein YP_002341875.1 339126 D 122587 CDS YP_002341876.1 218767364 906373 342177..343565 1 NC_003116.1 NMA0370, probable integral membrane protein, len: 462 aa; similar to hypothetical proteins e.g. Y325_HAEIN P44640 hypothetical protein HI0325 (450 aa), fasta scores; E(): 0, 49.8% identity in 464 aa overlap; integral membrane protein 343565 906373 NMA0370 Neisseria meningitidis Z2491 integral membrane protein YP_002341876.1 342177 D 122587 CDS YP_002341877.1 218767365 906374 343566..343790 1 NC_003116.1 NMA0371, slyX, SLYX protein homolog, len: 74 aa; simlar to SLYX_HAEIN P44759 SLYX protein homolog (73 aa),fasta scores; E(): 0.0017, 33.8% identity in 74 aa overlap, and SLYX_ECOLI P30857 SLYX protein (72 aa), fasta scores; E(): 0.24, 32.4% identity in 68 aa overlap; hypothetical protein 343790 slyX 906374 slyX Neisseria meningitidis Z2491 hypothetical protein YP_002341877.1 343566 D 122587 CDS YP_002341878.1 218767366 906376 complement(344185..344955) 1 NC_003116.1 NMA0373, thiF, probable ThiF protein, len: 256 aa; similar to e.g. THIF_ECOLI P30138 THIF protein (251 aa),fasta scores; E(): 0, 43.1% identity in 246 aa overlap, and MOEB_ECOLI P12282 molybdopterin biosynthesis MOEB protein. (249 aa), fasta scores; E(): 0, 43.9% identity in 244 aa overlap (note that N.m. does not have NMB_orthologues of any other molybdopterin biosynthesis proteins). Contains Pfam match to entry PF00899 ThiF_family, ThiF family; ThiF protein 344955 906376 NMA0373 Neisseria meningitidis Z2491 ThiF protein YP_002341878.1 344185 R 122587 CDS YP_002341879.1 218767367 906377 345121..347823 1 NC_003116.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 347823 ppc 906377 ppc Neisseria meningitidis Z2491 phosphoenolpyruvate carboxylase YP_002341879.1 345121 D 122587 CDS YP_002341880.1 218767368 906378 347946..348935 1 NC_003116.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 348935 gpsA 906378 gpsA Neisseria meningitidis Z2491 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002341880.1 347946 D 122587 CDS YP_002341881.1 218767369 906379 348990..349319 1 NC_003116.1 NMA0376, unknown, len: 109 aa; contains several coiled-coil domains; hypothetical protein 349319 906379 NMA0376 Neisseria meningitidis Z2491 hypothetical protein YP_002341881.1 348990 D 122587 CDS YP_002341882.1 218767370 906380 349330..349635 1 NC_003116.1 NMA0377, unknown, len: 101 aa; some similarity to YGFE_ECOLI P45580 (109 aa), fasta scores; E(): 0.00018,29.5% identity in 95 aa overlap; hypothetical protein 349635 906380 NMA0377 Neisseria meningitidis Z2491 hypothetical protein YP_002341882.1 349330 D 122587 CDS YP_002341883.1 218767371 906381 349998..350429 1 NC_003116.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 350429 rplM 906381 rplM Neisseria meningitidis Z2491 50S ribosomal protein L13 YP_002341883.1 349998 D 122587 CDS YP_002341884.1 218767372 906382 350439..350831 1 NC_003116.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 350831 rpsI 906382 rpsI Neisseria meningitidis Z2491 30S ribosomal protein S9 YP_002341884.1 350439 D 122587 CDS YP_002341885.1 218767373 906384 complement(351086..352015) 1 NC_003116.1 NMA0381, metR, probable transcriptional activator protein METR, len: 309 aa; similar to METR_HAEIN P45349 transcriptional activator protein METR (309 aa), fasta scores; E(): 0, 68.4% identity in 304 aa overlap, and METR_ECOLI P19797 transcriptional activator protein METR (317 aa), fasta scores; E(): 0, 44.0% identity in 298 aa overlap. Contains Pfam match to entry PF00126 HTH_1,Bacterial regulatory helix-turn-helix protein, lysR family, and PS00044 Bacterial regulatory proteins, lysR family signature; transcriptional activator protein METR 352015 906384 NMA0381 Neisseria meningitidis Z2491 transcriptional activator protein METR YP_002341885.1 351086 R 122587 CDS YP_002341886.1 218767374 906385 352146..352895 1 NC_003116.1 NMA0382, unknown, len: 249 aa; similar to hypothetical proteins e.g. YBGI_HAEIN Q57354 hypothetical protein HI0105 (279 aa), fasta scores; E(): 0, 49.8% identity in 241 aa overlap; hypothetical protein 352895 906385 NMA0382 Neisseria meningitidis Z2491 hypothetical protein YP_002341886.1 352146 D 122587 CDS YP_002341887.1 218767375 906386 353018..353599 1 NC_003116.1 NMA0383, petA, ubiquinol-cytochrome c reductase iron-sulfur subunit, len: 193 aa; similar to many e.g. UCRI_CHRVI O31214 ubiquinol-cytochrome c reductase iron-sulfur subunit (EC 1.10.2.2) (207 aa), fasta scores; E(): 0, 59.6% identity in 193 aa overlap. Contains Pfam match to entry PF00355 Rieske, Rieske iron-sulfur protein, and PS00200 Rieske iron-sulfur protein signature 2; ubiquinol-cytochrome c reductase iron-sulfur subunit 353599 906386 NMA0383 Neisseria meningitidis Z2491 ubiquinol-cytochrome c reductase iron-sulfur subunit YP_002341887.1 353018 D 122587 CDS YP_002341888.1 218767376 906387 353618..354967 1 NC_003116.1 NMA0384, petB, cytochrome B, len: 449 aa; similar to many e.g. CYB_CHRVI O31215 Chromatium vinosum cytochrome B (EC 1.10.2.2) (411 aa), fasta scores; E(): 0,62.9% identity in 407 aa overlap. Contains Pfam match to entry PF00033 cytochrome_b_N, Cytochrome b(N-terminal)/b6/petB, Pfam match to entry PF00032 cytochrome_b_C, Cytochrome b(C-terminal)/b6/petD, and PS00192 Cytochrome b/b6 heme-ligand signature; cytochrome B 354967 906387 NMA0384 Neisseria meningitidis Z2491 cytochrome B YP_002341888.1 353618 D 122587 CDS YP_002341889.1 218767377 906388 354982..355770 1 NC_003116.1 NMA0385, petC, cytochrome C1 precursor, len: 262 aa; similar to e.g. CY1_CHRVI O31216 cytochrome C1 precursor (244 aa), fasta scores; E(): 2.8e-27, 47.1% identity in 255 aa overlap. Contains PS00190 Cytochrome c family heme-binding site signature; cytochrome C1 precursor 355770 906388 NMA0385 Neisseria meningitidis Z2491 cytochrome C1 precursor YP_002341889.1 354982 D 122587 CDS YP_002341890.1 218767378 906389 356109..357893 1 NC_003116.1 NMA0386, probable periplasmic protein, len: 594 aa; similar to YIGN_ECOLI P27850 hypothetical 54.7 kd protein (475 aa), fasta scores; E(): 0, 44.3% identity in 404 aa overlap. Contains N-terminal signal sequence and several coiled-coil domains in N-terminal half; hypothetical protein 357893 906389 NMA0386 Neisseria meningitidis Z2491 hypothetical protein YP_002341890.1 356109 D 122587 CDS YP_002341891.1 218767379 906390 complement(358099..358731) 1 NC_003116.1 NMA0387, hydrolase, len: 210 aa; similar to many hypothetical proteins belonging to the glyoxalase II family e.g. YCBL_ECOLI P75849 (215 aa), fasta scores; E(): 0, 47.1% identity in 208 aa overlap. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily; hydrolase 358731 906390 NMA0387 Neisseria meningitidis Z2491 hydrolase YP_002341891.1 358099 R 122587 CDS YP_002341892.1 218767380 906391 358822..359646 1 NC_003116.1 catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA; DNA ligase 359646 906391 NMA0388 Neisseria meningitidis Z2491 DNA ligase YP_002341892.1 358822 D 122587 CDS YP_002341893.1 218767381 906392 359715..360278 1 NC_003116.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 360278 hpt 906392 hpt Neisseria meningitidis Z2491 hypoxanthine-guanine phosphoribosyltransferase YP_002341893.1 359715 D 122587 CDS YP_002341894.1 218767382 906393 360359..360796 1 NC_003116.1 NMA0390, probable sugar transport PTS system IIA component, len: 145 aa; simlar to e.g. PTFA_BACSU P26379 PTS system, fructose-specific IIA component (EC 2.7.1.69) (146 aa), fasta scores; E(): 0.053, 26.2% identity in 103 aa overlap, and the N-terminal domain of PTNA_ECOLI P08186 PTS system, mannose-specific IIAB component (322 aa),fasta scores; E(): 8.8e-06, 30.1% identity in 136 aa overlap; sugar transport PTS system IIA component 360796 906393 NMA0390 Neisseria meningitidis Z2491 sugar transport PTS system IIA component YP_002341894.1 360359 D 122587 CDS YP_002341895.1 218767383 906394 360865..361134 1 NC_003116.1 NMA0391, ptsH, probable sugar transport PTS system phosphocarrier protein HPR, len: aa; similar to many e.g PTHP_ALCEU P23537 phosphocarrier protein HPR (89 aa),fasta scores; E(): 2.6e-17, 59.6% identity in 89 aa overlap. Contains Pfam match to entry PF00381 PTS-HPr, PTS HPr component phosphorylation sites, and PS00012 Phosphopantetheine attachment site; sugar transport PTS system phosphocarrier protein HPR 361134 906394 NMA0391 Neisseria meningitidis Z2491 sugar transport PTS system phosphocarrier protein HPR YP_002341895.1 360865 D 122587 CDS YP_002341896.1 218767384 906395 361134..362909 1 NC_003116.1 NMA0392, ptsI, probable phosphoenolpyruvate-protein phosphotransferase (phosphotransferase system, enzyme I),len: aa; similar to many e.g. PT1_ALCEU P23536 phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (592 aa), fasta scores; E(): 0, 46.1% identity in 583 aa overlap. Contains 2x Pfam match to entry PF00391 PEP-utilizers, PEP-utilizing enzymes, and PS00742 PEP-utilizing enzymes signature 2; phosphoenolpyruvate-protein phosphotransferase 362909 906395 NMA0392 Neisseria meningitidis Z2491 phosphoenolpyruvate-protein phosphotransferase YP_002341896.1 361134 D 122587 CDS YP_002341897.1 218767385 906396 complement(363353..364291) 1 NC_003116.1 NMA0393, probable ABC-transport system ATP-binding protein, len: 312 aa; similar to e.g. POTA_ECOLI P23858 spermidine/putrescine transport atp-binding protein POTA (378 aa), fasta scores; E(): 0, 44.5% identity in 281 aa overlap. Contains Pfam match to entry PF00005 ABC_tran,ABC transporter, PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature; ABC transporter ATP-binding protein 364291 906396 NMA0393 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002341897.1 363353 R 122587 CDS YP_002341898.1 218767386 906397 complement(364300..365175) 1 NC_003116.1 NMA0394, unknown, len:291 aa; some similarity to N-terminus of TNR3_SCHPO P41888 thiamine pyrophosphokinase (569 aa), fasta scores; E(): 4.7e-18, 30.4% identity in 260 aa overlap; hypothetical protein 365175 906397 NMA0394 Neisseria meningitidis Z2491 hypothetical protein YP_002341898.1 364300 R 122587 CDS YP_002341899.1 218767387 906400 365773..367674 1 NC_003116.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 367674 thiC 906400 thiC Neisseria meningitidis Z2491 thiamine biosynthesis protein ThiC YP_002341899.1 365773 D 122587 CDS YP_002341900.1 218767388 906401 complement(369454..370443) 1 NC_003116.1 NMA0398, porB, porin, major outer membrane protein P.I, len: 329 aa; almost identical to many e.g. OMB2_NEIME P30688 major outer membrane protein P.IB precursor (331 aa), fasta scores; E(): 0, 94.9% identity in 331 aa overlap. Contains Pfam match to entry PF00267 Gram-ve_porins, General diffusion Gram-negative porins, and PS00576 General diffusion Gram-negative porins signature. Also similar to NMA1642, porA (43.7% identity in 398 aa overlap); porin 370443 906401 NMA0398 Neisseria meningitidis Z2491 porin YP_002341900.1 369454 R 122587 CDS YP_002341901.1 218767389 906402 complement(371688..372005) 1 NC_003116.1 NMA0400, chpA, PEMK-like protein, len: 105 aa; simlar to e.g. CHPA_ECOLI P33645 PEMK-like protein 1 (MAZF protein) (111 aa), fasta scores; E(): 7e-06, 38.9% identity in 72 aa overlap, and PEMK_ECOLI P13976 Plasmid IncFII R100 PEMK protein (133 aa), fasta scores; E(): 5.9e-05, 32.7% identity in 107 aa overlap; PEMK-like protein 372005 906402 NMA0400 Neisseria meningitidis Z2491 PEMK-like protein YP_002341901.1 371688 R 122587 CDS YP_002341902.1 218767390 906403 complement(371999..372238) 1 NC_003116.1 NMA0401, unknonwn, len: 79 aa; hypothetical protein 372238 906403 NMA0401 Neisseria meningitidis Z2491 hypothetical protein YP_002341902.1 371999 R 122587 CDS YP_002341903.1 218767391 906404 complement(372361..373158) 1 NC_003116.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 373158 truA 906404 truA Neisseria meningitidis Z2491 tRNA pseudouridine synthase A YP_002341903.1 372361 R 122587 CDS YP_002341904.1 218767392 906405 complement(374566..375258) 1 NC_003116.1 NMA0403, unknown, len: 230 aa; almost identical to TR:AAD38302 (EMBL:AF036242) N. meningitidis NMB hypothetical 26.3 kd protein (230 aa), fasta scores; E(): 0, 97.4% identity in 230 aa overlap, and similar to TR:O28566 (EMBL:AE000985) Archaeoglobus fulgidus AF1707 (219 aa), fasta scores; E(): 5.6e-06, 25.1% identity in 215 aa overlap. Also similar to NMA0032 (53.5% identity in 230 aa overlap); hypothetical protein 375258 906405 NMA0403 Neisseria meningitidis Z2491 hypothetical protein YP_002341904.1 374566 R 122587 CDS YP_002341905.1 218767393 906406 complement(375255..375998) 1 NC_003116.1 NMA0404, nlaB, probable 1-acyl-SN-glycerol-3-phosphate acyltransferase, len: 247 aa; identical to TR:AAD38301 (EMBL:AF036242) N. meningitidis NMB lysophosphatidic acid acyltransferase homolog (247 aa), and similar to many e.g. PLSC_BORBU Q59188 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) (250 aa), fasta scores; E(): 4e-11, 31.4% identity in 226 aa overlap. Also similar to NMA1504, plsC (23.6% identity in 148 aa overlap). Contains N-terminal signal sequence; 1-acyl-SN-glycerol-3-phosphate acyltransferase 375998 906406 NMA0404 Neisseria meningitidis Z2491 1-acyl-SN-glycerol-3-phosphate acyltransferase YP_002341905.1 375255 R 122587 CDS YP_002341906.1 218767394 906407 complement(376027..376590) 1 NC_003116.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 376590 906407 NMA0405 Neisseria meningitidis Z2491 D,D-heptose 1,7-bisphosphate phosphatase YP_002341906.1 376027 R 122587 CDS YP_002341907.1 218767395 906409 377328..378980 1 NC_003116.1 NMA0408, probable integral membrane protein, len: 550 aa; highly similar to Y275_HAEIN P43975 hypothetical protein HI0275 (551 aa), fasta scores; E(): 0, 68.4% identity in 551 aa overlap; integral membrane protein 378980 906409 NMA0408 Neisseria meningitidis Z2491 integral membrane protein YP_002341907.1 377328 D 122587 CDS YP_002341908.1 218767396 906410 complement(379050..380291) 1 NC_003116.1 NMA0409, probable amino-acid transport protein,len: 413 aa; similar to many e.g. MTR_ECOLI P22306 tryptophan-specific transport protein (414 aa), fasta scores; E(): 0, 47.1% identity in 408 aa overlap,TNAB_ECOLI P23173 low affinity tryptophan permease (415 aa), fasta scores; E(): 0, 43.5% identity in 409 aa overlap, and TYRP_ECOLI P18199 tyrosine-specific transport protein (403 aa), fasta scores; E(): 0, 36.9% identity in 401 aa overlap. Contains PS00594 Aromatic amino acids permeases signature; amino-acid transport protein 380291 906410 NMA0409 Neisseria meningitidis Z2491 amino-acid transport protein YP_002341908.1 379050 R 122587 CDS YP_002341909.1 218767397 906411 380455..381171 1 NC_003116.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 381171 ubiG 906411 ubiG Neisseria meningitidis Z2491 3-demethylubiquinone-9 3-methyltransferase YP_002341909.1 380455 D 122587 CDS YP_002341910.1 218767398 906412 381201..382124 1 NC_003116.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine; homoserine kinase 382124 thrB 906412 thrB Neisseria meningitidis Z2491 homoserine kinase YP_002341910.1 381201 D 122587 CDS YP_002341911.1 218767399 906413 complement(382463..382981) 1 NC_003116.1 NMA0412, probable glucokinase, len: 172 aa; similar to e.g. GNTK_SCHPO Q10242 probable gluconokinase (EC 2.7.1.12) (193 aa), fasta scores; E(): 1.8e-17, 41.5% identity in 176 aa overlap, GNTV_ECOLI P39208 thermosensitive gluconokinase (EC 2.7.1.12) (187 aa),fasta scores; E(): 2e-15, 41.8% identity in 134 aa overlap, and GNTK_ECOLI P46859 thermoresistant gluconokinase (EC 2.7.1.12) (175 aa), fasta scores; E(): 1.2e-16, 37.4% identity in 163 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); glucokinase 382981 906413 NMA0412 Neisseria meningitidis Z2491 glucokinase YP_002341911.1 382463 R 122587 CDS YP_002341912.1 218767400 906414 complement(383001..384386) 1 NC_003116.1 NMA0413, gntP, probable gluconate permease, len: 461 aa; similar to many e.g. GNTP_BACSU Q9ZIJ1 gluconate permease (448 aa), fasta scores; E(): 0, 37.1% identity in 453 aa overlap; gluconate permease 384386 906414 NMA0413 Neisseria meningitidis Z2491 gluconate permease YP_002341912.1 383001 R 122587 CDS YP_002341913.1 218767401 906415 384727..386319 1 NC_003116.1 NMA0414, probable permease, len: 530 aa; similar to many e.g. YABK_ECOLI P31549 (536 aa), fasta scores; E(): 1.1e-14, 28.0% identity in 517 aa overlap, and MODB_ECOLI P09834 molybdenum transport system permease (229 aa), fasta scores; E(): 9.1e-12, 29.8% identity in 198 aa overlap. Contains 2x Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, and PS00402 Binding-protein-dependent transport systems inner membrane comp sign; permease 386319 906415 NMA0414 Neisseria meningitidis Z2491 permease YP_002341913.1 384727 D 122587 CDS YP_002341914.1 218767402 906416 386348..386947 1 NC_003116.1 NMA0415, unknown, len: 199 aa; similar to hypothetical proteins e.g. TR:O34872 (EMBL:AF008220) Bacillus subtilis YTIB (187 aa), fasta scores; E(): 0,55.4% identity in 184 aa overlap, and to CYNT_ECOLI P17582 carbonic anhydrase (EC 4.2.1.1) (219 aa), fasta scores; E(): 0.067, 31.5% identity in 108 aa overlap; hypothetical protein 386947 906416 NMA0415 Neisseria meningitidis Z2491 hypothetical protein YP_002341914.1 386348 D 122587 CDS YP_002341915.1 218767403 906417 386944..387537 1 NC_003116.1 NMA0416, unknown, len: 197 aa; similar to many hypothetical proteins, e.g. YQEJ_BACSU P54455 (189 aa),fasta scores; E(): 1.7e-17, 35.5% identity in 203 aa overlap; hypothetical protein 387537 906417 NMA0416 Neisseria meningitidis Z2491 hypothetical protein YP_002341915.1 386944 D 122587 CDS YP_002341916.1 218767404 906418 387596..387982 1 NC_003116.1 NMA0417, unknown, len: 128 aa; similar to many hypothetical proteins, e.g. YBEB_ECOLI P05848 (105 aa),fasta scores; E(): 3e-10, 36.4% identity in 110 aa overlap; hypothetical protein 387982 906418 NMA0417 Neisseria meningitidis Z2491 hypothetical protein YP_002341916.1 387596 D 122587 CDS YP_002341917.1 218767405 906419 388036..388506 1 NC_003116.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 388506 906419 NMA0418 Neisseria meningitidis Z2491 rRNA large subunit methyltransferase YP_002341917.1 388036 D 122587 CDS YP_002341918.1 218767406 906420 388579..388845 1 NC_003116.1 NMA0419, unknown, len: 88 aa; similar to many hypothetical proteins, e.g. YGGX_ECOLI P52065 (90 aa),fasta scores; E(): 8.2e-15, 44.3% identity in 88 aa overlap. Contains GC(6) repeat near C-terminus; hypothetical protein 388845 906420 NMA0419 Neisseria meningitidis Z2491 hypothetical protein YP_002341918.1 388579 D 122587 CDS YP_002341919.1 218767407 906421 389002..389685 1 NC_003116.1 NMA0420, probable integral membrane protein, len: 227 aa; similar to many hypothetical proteins, e.g. YCCA_ECOLI P06967 (219 aa), fasta scores; E(): 2.5e-18,36.7% identity in 215 aa overlap. Contains Pfam match to entry PF01027 UPF0005, Uncharacterized protein family; integral membrane protein 389685 906421 NMA0420 Neisseria meningitidis Z2491 integral membrane protein YP_002341919.1 389002 D 122587 CDS YP_002341920.1 218767408 906422 389809..390321 1 NC_003116.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 390321 coaD 906422 coaD Neisseria meningitidis Z2491 phosphopantetheine adenylyltransferase YP_002341920.1 389809 D 122587 CDS YP_002341921.1 218767409 906423 390347..391009 1 NC_003116.1 NMA0422, probable psedouridine synthase, len: 220 aa; similar to hypothetical proteins e.g. Y042_HAEIN P43930 hypothetical protein HI0042 (224 aa), fasta scores; E(): 0, 51.9% identity in 214 aa overlap, and to ribosomal psedouridine synthases e.g. RLUA_ECOLI P39219 ribosomal large subunit pseudouridine synthase A (218 aa), fasta scores; E(): 9.3e-12, 33.5% identity in 182 aa overlap. Contains Pfam match to entry PF00849 YABO, Hypothetical yabO/yceC/sfhB family, and PS01129 Hypothetical yabO/yceC/sfhB family signature; psedouridine synthase 391009 906423 NMA0422 Neisseria meningitidis Z2491 psedouridine synthase YP_002341921.1 390347 D 122587 CDS YP_002341922.1 218767410 906424 396694..397158 1 NC_003116.1 NMA0423, DNA transport competence protein,len: 154 aa; region of similarity to SW:P39694 (CME1_BACSU) ComE a late competence operon protein from Bacillus subtilis (205 aa) fasta scores; E(): 6.2e-07,47.6% identity in 63 aa overlap. Almost identical to TR:CAB44958 (EMBL:AJ242837) ComEA protein (fragment) from Neisseria meningitidis serogroup A strain Z2491 (170 aa) fasta scores; E(): 0, 98.7% identity in 154 aa overlap. Contains Pfam match to entry PF00633 HHH,Helix-hairpin-helix motif and membrane-spanning hydrophobic region. Identical to NMA0211, and almost identical to NMA1915 (98.7% identity in 154 aa overlap), and NMA2187 (98.7% identity in 154 aa overlap); DNA transport competence protein 397158 906424 NMA0423 Neisseria meningitidis Z2491 DNA transport competence protein YP_002341922.1 396694 D 122587 CDS YP_002341923.1 218767411 906425 397246..397695 1 NC_003116.1 NMA0424, probable pilin, len: 149 aa; similar to e.g. FMM1_NEIGO P02974 fimbrial protein precursor (pilin) (165 aa), fasta scores; E(): 0.00029, 24.7% identity in 154 aa overlap. Contains PS00409 Prokaryotic N-terminal methylation site; pilin 397695 906425 NMA0424 Neisseria meningitidis Z2491 pilin YP_002341923.1 397246 D 122587 CDS YP_002341924.1 218767412 906426 complement(397856..398125) 1 NC_003116.1 NMA0425, unknown, len: 89 aa; hypothetical protein 398125 906426 NMA0425 Neisseria meningitidis Z2491 hypothetical protein YP_002341924.1 397856 R 122587 CDS YP_002341925.1 218767413 906428 398752..399807 1 NC_003116.1 NMA0427, probable modification methylase (cytosine-specific DNA methylase), len: 351 aa; similar to many e.g. MTD2_HERAU P25265 modification methylase HgiDII (EC ) (354 aa), fasta scores; E(): 0, 39.7% identity in 345 aa overlap. Contains 2x Pfam match to entry PF00145 DNA_methylase, C-5 cytosine-specific DNA methylase; cytosine-specific DNA methylase 399807 906428 NMA0427 Neisseria meningitidis Z2491 cytosine-specific DNA methylase YP_002341925.1 398752 D 122587 CDS YP_002341926.1 218767414 906429 399821..401467 1 NC_003116.1 NMA0428, conserved hypothetical protein, len: 560aa; similar to many of undefined function eg. SW:P25280 (YD3M_HERAU) hypothetical protein from Herpetosiphon aurantiacus (Herpetosiphon giganteus) (611 aa) fasta scores; E(): 2.6e-15, 30.1% identity in 369 aa overlap. Lies in a region of unusually low GC content. Also shows weak similarity to SW:P70754 (MUTL_AQUPY) DNA mismatch repair protein from Aquifex pyrophilus (426 aa) fasta scores; E(): 4.4, 26.4% identity in 292 aa overlap.; hypothetical protein 401467 906429 NMA0428 Neisseria meningitidis Z2491 hypothetical protein YP_002341926.1 399821 D 122587 CDS YP_002341927.1 218767415 906430 401471..401893 1 NC_003116.1 NMA0429, vsr, patch repair protein, len: 140aa; similar to SW:P09184 (VSR_ECOLI) vsr, patch repair protein from Escherichia coli (156 aa) fasta scores; E(): 9.8e-21,39.3% identity in 122 aa overlap. Lies in a region of unusually low GC content.; patch repair protein 401893 906430 NMA0429 Neisseria meningitidis Z2491 patch repair protein YP_002341927.1 401471 D 122587 CDS YP_002341928.1 218767416 906431 complement(401916..405041) 1 NC_003116.1 NMA0430, DNA helicase, len: 1041aa; regions similar to many eg. SW:P43329 (HRPA_ECOLI) ATP-dependent helicase from Escherichia coli (1281 aa) fasta scores; E(): 0, 30.6% identity in 1035 aa overlap. Contains a direct degenerate repeat (408-473, 474-531) which is absent from homologues.; DNA helicase 405041 906431 NMA0430 Neisseria meningitidis Z2491 DNA helicase YP_002341928.1 401916 R 122587 CDS YP_002341929.1 218767417 906432 complement(405107..406381) 1 NC_003116.1 NMA0431, inner membrane protein, len: 424aa; contains membrane-spanning hydrophobic regions. Lies in a region of unusually low GC content.; inner membrane protein 406381 906432 NMA0431 Neisseria meningitidis Z2491 inner membrane protein YP_002341929.1 405107 R 122587 CDS YP_002341930.1 218767418 906433 complement(406562..407689) 1 NC_003116.1 NMA0432, hypothetical protein, len: 375aa; hypothetical protein 407689 906433 NMA0432 Neisseria meningitidis Z2491 hypothetical protein YP_002341930.1 406562 R 122587 CDS YP_002341931.1 218767419 906434 complement(407790..409181) 1 NC_003116.1 NMA0433, hrpA', ATP-dependent DNA helicase, len: 495aa; similar to regions of many eg. SW:P43329 (HRPA_ECOLI) hrpA, ATP-dependent DNA helicase from Escherichia coli (1281 aa) fasta scores; E(): 0, 64.5% identity in 453 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; ATP-dependent DNA helicase 409181 906434 NMA0433 Neisseria meningitidis Z2491 ATP-dependent DNA helicase YP_002341931.1 407790 R 122587 CDS YP_002341932.1 218767420 906435 complement(409371..410780) 1 NC_003116.1 NMA0434, hypothetical inner membrane protein, len: 469aa; similar to SW:P37019 (YADQ_ECOLI) hypothetical protein from Escherichia coli (436 aa) fasta scores; E(): 1e-18, 29.2% identity in 449 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 410780 906435 NMA0434 Neisseria meningitidis Z2491 hypothetical protein YP_002341932.1 409371 R 122587 CDS YP_002341933.1 218767421 906436 complement(410943..412163) 1 NC_003116.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 412163 argJ 906436 argJ Neisseria meningitidis Z2491 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase YP_002341933.1 410943 R 122587 CDS YP_002341934.1 218767422 906437 complement(412230..412922) 1 NC_003116.1 NMA0436, hypothetical inner membrane protein, len: 230aa; similar to many eg. SW:P33373 (YOHK_ECOLI) hypothetical protein from Escherichia coli (231 aa) fasta scores; E(): 4.3e-26, 39.0% identity in 218 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 412922 906437 NMA0436 Neisseria meningitidis Z2491 hypothetical protein YP_002341934.1 412230 R 122587 CDS YP_002341935.1 218767423 906438 complement(412922..413266) 1 NC_003116.1 NMA0437, hypothetical inner membrane protein, len: 114aa; similar to many eg. SW:P39591 (YWBH_BACSU) hypothetical protein from Bacillus subtilis (128 aa) fasta scores; E(): 1.9e-07, 36.0% identity in 111 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 413266 906438 NMA0437 Neisseria meningitidis Z2491 hypothetical protein YP_002341935.1 412922 R 122587 CDS YP_002341936.1 218767424 906440 complement(413411..413629) 1 NC_003116.1 NMA0439, hypothetical protein, len: 72aa; hypothetical protein 413629 906440 NMA0439 Neisseria meningitidis Z2491 hypothetical protein YP_002341936.1 413411 R 122587 CDS YP_002341937.1 218767425 906441 complement(413648..414490) 1 NC_003116.1 NMA0440, hypothetical outer membrane protein, len: 280aa; C-terminal region similar to many eg. SW:P76190 (YDHO_ECOLI) hypothetical protein from Escherichia coli (271 aa) fasta scores; E(): 1.2e-18, 50.9% identity in 116 aa overlap, similar to NMA1645 fasta scores; E(): 2.4e-20,45.8% identity in 120 aa overlap and contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family, includes several lipoproteins. N-terminal region contains 4 x EQPVLP(V/I)NR(A/V)PARRAGNADELIG(N/S)AMGL(N/L) repeat.; hypothetical outer membrane protein 414490 906441 NMA0440 Neisseria meningitidis Z2491 hypothetical outer membrane protein YP_002341937.1 413648 R 122587 CDS YP_002341938.1 218767426 906442 414735..415643 1 NC_003116.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 415643 hslO 906442 hslO Neisseria meningitidis Z2491 Hsp33-like chaperonin YP_002341938.1 414735 D 122587 CDS YP_002341939.1 218767427 906443 complement(415729..417183) 1 NC_003116.1 NMA0442, hypothetical inner membrane protein, len: 484aa; similar to many proposed transporters eg. TR:P73368 (EMBL:D90905) proposed Mg2+ transporter from Synechocystis sp. (strain PCC 6803) (463 aa) fasta scores; E(): 0, 30.6% identity in 422 aa overlap. Contains two Pfam matches to entry PF00571 CBS, CBS domain.; hypothetical protein 417183 906443 NMA0442 Neisseria meningitidis Z2491 hypothetical protein YP_002341939.1 415729 R 122587 CDS YP_002341940.1 218767428 906444 complement(417417..418169) 1 NC_003116.1 NMA0444, probable hydroxyacylglutathione hydrolase,len: 250aa; similar to many eg. SW:Q47677 (GLO2_ECOLI) probable hydroxyacylglutathione hydrolase from Escherichia coli (251 aa) fasta scores; E(): 2.6e-26, 37.5% identity in 259 aa overlap. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily.; hydroxyacylglutathione hydrolase 418169 906444 NMA0444 Neisseria meningitidis Z2491 hydroxyacylglutathione hydrolase YP_002341940.1 417417 R 122587 CDS YP_002341941.1 218767429 906445 complement(418264..422226) 1 NC_003116.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 422226 purL 906445 purL Neisseria meningitidis Z2491 phosphoribosylformylglycinamidine synthase YP_002341941.1 418264 R 122587 CDS YP_002341942.1 218767430 906446 422690..423028 1 NC_003116.1 NMA0447, glnB, nitrogen regulatory protein P-II 1,len: 112aa; similar to many eg. SW:P05826 (GLNB_ECOLI) glnB, nitrogen regulatory protein P-II 1 from Escherichia coli (112 aa) fasta scores; E(): 1.9e-31, 74.1% identity in 112 aa overlap. Contains Pfam match to entry PF00543 P-II, Nitrogen regulatory protein P-II; Prosite match to PS00496 P-II protein urydylation site and Prosite match to PS00638 P-II protein C-terminal region signature; nitrogen regulatory protein P-II 1 423028 906446 NMA0447 Neisseria meningitidis Z2491 nitrogen regulatory protein P-II 1 YP_002341942.1 422690 D 122587 CDS YP_002341943.1 218767431 906447 complement(423084..423842) 1 NC_003116.1 NMA0448, probable ABC transporter ATP-binding subunit, len: 252aa; similar to many probable transporters eg. TR:P94420 (EMBL:D50453) from Bacillus subtilis (252 aa) fasta scores; E(): 0, 46.4% identity in 250 aa overlap. Contains Pfam match to entry PF00005 ABC_tran,ABC transporter; Prosite match to PS00211 ABC transporters family signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; ABC transporter ATP-binding protein 423842 906447 NMA0448 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002341943.1 423084 R 122587 CDS YP_002341944.1 218767432 906448 complement(423973..424554) 1 NC_003116.1 NMA0449, hypothetical protein, len: 193aa; hypothetical protein 424554 906448 NMA0449 Neisseria meningitidis Z2491 hypothetical protein YP_002341944.1 423973 R 122587 CDS YP_002341945.1 218767433 906449 complement(424599..425546) 1 NC_003116.1 NMA0450, inner membrane transport protein,len: 315aa; similar to many transport proteins eg. SW:P37737 (FATC_VIBAN) anguibactin transport protein from Vibrio anguillarum (317 aa) fasta scores; E(): 9.2e-27,29.3% identity in 307 aa overlap. Contains Pfam match to entry PF01032 FecCD_family, FecCD transport family; Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and membrane-spanning hydrophobic regions.; inner membrane transport protein 425546 906449 NMA0450 Neisseria meningitidis Z2491 inner membrane transport protein YP_002341945.1 424599 R 122587 CDS YP_002341946.1 218767434 906450 complement(425563..426531) 1 NC_003116.1 NMA0451, inner membrane transport protein,len: 322aa; similar to many transport proteins eg. SW:P37738 (FATD_VIBAN) anguibactin transport protein from Vibrio anguillarum (314 aa) fasta scores; E(): 0, 38.1% identity in 310 aa overlap. Contains Pfam match to entry PF01032 FecCD_family, FecCD transport family and membrane-spanning hydrophobic regions.; inner membrane transport protein 426531 906450 NMA0451 Neisseria meningitidis Z2491 inner membrane transport protein YP_002341946.1 425563 R 122587 CDS YP_002341947.1 218767435 906451 complement(426802..427767) 1 NC_003116.1 NMA0452, fetB, probable ferric enterobactin periplasmic binding protein, len: 321aa; similar to many eg. SW:P11460 (FATB_VIBAN) anguibactin binding protein from Vibrio anguillarum (322 aa) fasta scores; E(): 3.7e-22, 30.8% identity in 302 aa overlap and TR:AAD29611 (EMBL:AF115385) ferric enterobactin periplasmic binding protein from Neisseria gonorrhoeae (323 aa) fasta scores; E(): 0, 96.3% identity in 323 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site; membrane transport solute-binding protein 427767 906451 NMA0452 Neisseria meningitidis Z2491 membrane transport solute-binding protein YP_002341947.1 426802 R 122587 CDS YP_002341948.1 218767436 906452 complement(428465..430609) 1 NC_003116.1 NMA0453, fetA, probable ferric enterobactin receptor, len: 714aa; similar to many eg. TR:AAD29612 (EMBL:AF115385) FetA, ferric enterobactin receptor from Neisseria gonorrhoeae (713 aa) fasta scores; E(): 0, 95.0% identity in 714 aa overlap. Contains two Prosite match to PS01156 TonB-dependent receptor proteins signature 2.; iron-regulated outer membrane protein 430609 906452 NMA0453 Neisseria meningitidis Z2491 iron-regulated outer membrane protein YP_002341948.1 428465 R 122587 CDS YP_002341949.1 218767437 906453 complement(432471..433817) 1 NC_003116.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 433817 trmE 906453 trmE Neisseria meningitidis Z2491 tRNA modification GTPase TrmE YP_002341949.1 432471 R 122587 CDS YP_002341950.1 218767438 906454 433948..434103 1 NC_003116.1 NMA0455, hypothetical protein, len: 51aa; hypothetical protein 434103 906454 NMA0455 Neisseria meningitidis Z2491 hypothetical protein YP_002341950.1 433948 D 122587 CDS YP_002341951.1 218767439 906455 434100..434531 1 NC_003116.1 NMA0456, inner membrane protein, len: 143aa; contains membrane-spanning hydrophobic regions.; inner membrane protein 434531 906455 NMA0456 Neisseria meningitidis Z2491 inner membrane protein YP_002341951.1 434100 D 122587 CDS YP_002341952.1 218767440 906456 434665..439014 1 NC_003116.1 NMA0457, iga2, IgA-specific serine endopeptidase,len: 1449aa; similar to many eg. SW:P09790 (IGA_NEIGO) iga, IgA-specific serine endopeptidase from Neisseria gonorrhoeae (1532 aa) fasta scores; E(): 0, 28.8% identity in 1594 aa overlap. Contains Prosite match to PS00135 Serine proteases, trypsin family, serine active site. Also similar to NMA0905, iga (29.9% identity in 1339 aa overlap); IgA-specific serine endopeptidase 439014 906456 NMA0457 Neisseria meningitidis Z2491 IgA-specific serine endopeptidase YP_002341952.1 434665 D 122587 CDS YP_002341953.1 218767441 906457 complement(439330..440442) 1 NC_003116.1 NMA0458, transposase for insertion element IS1106A3, len: 370aa; similar to many eg. TR:CAB44967 (EMBL:AJ242841) transposase for insertion element IS1106A3 from Neisseria meningitidis serogroup A strain Z2491 (this strain) (335 aa) fasta scores; E(): 0, 84.6% identity in 370 aa overlap. Also similar to many others on this chromosome eg. NMA1115 (fasta scores; E(): 0, 85.7% identity in 370 aa overlap).; transposase for insertion element IS1106A3 440442 906457 NMA0458 Neisseria meningitidis Z2491 transposase for insertion element IS1106A3 YP_002341953.1 439330 R 122587 CDS YP_002341954.1 218767442 906458 complement(440504..441175) 1 NC_003116.1 NMA0459, hypothetical protein, len: 223aa; similar to TRNEW:AAD39623 (EMBL:AF069302) hypothetical protein from Pediococcus pentosaceus (231 aa) fasta scores; E(): 2.6e-27, 38.1% identity in 223 aa overlap.; hypothetical protein 441175 906458 NMA0459 Neisseria meningitidis Z2491 hypothetical protein YP_002341954.1 440504 R 122587 CDS YP_002341955.1 218767443 906460 complement(441995..444811) 1 NC_003116.1 NMA0462, polA, DNA polymerase I, len: 938aa; similar to many eg. SW:P00582 (DPO1_ECOLI) polA, DNA polymerase I from Escherichia coli (928 aa) fasta scores; E(): 0, 52.5% identity in 946 aa overlap. Contains Pfam match to entry PF00476 DNA_pol_A, DNA polymerase family A; Pfam match to entry PF01367 5_3_exonuclease, 5'-3' exonuclease and Prosite match to PS00447 DNA polymerase family A signature.; DNA polymerase I 444811 906460 NMA0462 Neisseria meningitidis Z2491 DNA polymerase I YP_002341955.1 441995 R 122587 CDS YP_002341956.1 218767444 906461 complement(444957..445463) 1 NC_003116.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 445463 906461 NMA0463 Neisseria meningitidis Z2491 S-ribosylhomocysteinase YP_002341956.1 444957 R 122587 CDS YP_002341957.1 218767445 906462 complement(445485..445904) 1 NC_003116.1 NMA0464, hypothetical protein, len: 139aa; similar to SW:P44078 (Y931_HAEIN) hypothetical protein from Haemophilus influenzae (161 aa) fasta scores; E(): 7.7e-13, 40.7% identity in 123 aa overlap.; hypothetical protein 445904 906462 NMA0464 Neisseria meningitidis Z2491 hypothetical protein YP_002341957.1 445485 R 122587 CDS YP_002341958.1 218767446 906463 complement(445930..446946) 1 NC_003116.1 NMA0465, hypothetical inner membrane protein, len: 338aa; similar to SW:P45290 (YEIH_HAEIN) hypothetical protein from Haemophilus influenzae (338 aa) fasta scores; E(): 0, 93.2% identity in 338 aa overlap. Contains membrane-spanning hydrophobic regions. Lies in a region of unusually low GC content.; hypothetical protein 446946 906463 NMA0465 Neisseria meningitidis Z2491 hypothetical protein YP_002341958.1 445930 R 122587 CDS YP_002341959.1 218767447 906464 complement(446973..447296) 1 NC_003116.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 447296 cyaY 906464 cyaY Neisseria meningitidis Z2491 frataxin-like protein YP_002341959.1 446973 R 122587 CDS YP_002341960.1 218767448 906465 447367..447537 1 NC_003116.1 NMA0467, lipoprotein, len: 56aa; similar to SW:P17323 (LPPL_PSEAE) lipopeptide from Pseudomonas aeruginosa (46 aa) fasta scores; E(): 1.2, 44.4% identity in 45 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein 447537 906465 NMA0467 Neisseria meningitidis Z2491 lipoprotein YP_002341960.1 447367 D 122587 CDS YP_002341961.1 218767449 906466 447548..448768 1 NC_003116.1 NMA0468, lysA, diaminopimelate decarboxylase, len: 406aa; similar to many eg. SW:P19572 (DCDA_PSEAE) lysA,diaminopimelate decarboxylase from Pseudomonas aeruginosa (415 aa) fasta scores; E(): 0, 59.0% identity in 400 aa overlap. Contains Pfam match to entry PF00278 Orn_DAP_Arg_deC, Pyridoxal-dependent decarboxylase and Prosite match to PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2.; diaminopimelate decarboxylase 448768 906466 NMA0468 Neisseria meningitidis Z2491 diaminopimelate decarboxylase YP_002341961.1 447548 D 122587 CDS YP_002341962.1 218767450 906467 complement(448917..450452) 1 NC_003116.1 NMA0470, sodium-dependent inner membrane transport protein, len: 511aa; similar to many eg. SW:P44849 (Y736_HAEIN) hypothetical sodium-dependent transporter (508 aa) fasta scores; E(): 0, 59.7% identity in 506 aa overlap. Contains membrane-spanning hydrophobic regions; two Pfam matches to entry PF00209 SNF, Sodium:neurotransmitter symporter family and Prosite match to PS00610 Sodium:neurotransmitter symporter family signature 1.; sodium-dependent inner membrane transport protein 450452 906467 NMA0470 Neisseria meningitidis Z2491 sodium-dependent inner membrane transport protein YP_002341962.1 448917 R 122587 CDS YP_002341963.1 218767451 906468 complement(450665..451318) 1 NC_003116.1 NMA0471, insertion element IS1016 transposase, len: 217 aa; similar to many eg. TR:Q48234 (EMBL:X59756) insertion sequence IS1016-V6 from Haemophilus influenzae (191 aa) fasta scores; E(): 0, 70.3% identity in 175 aa overlap. Also similar to many others on this chromosome eg. NMA2185 (fasta scores; E(): 0, 97.7% identity in 217 aa overlap).; insertion element IS1016 transposase 451318 906468 NMA0471 Neisseria meningitidis Z2491 insertion element IS1016 transposase YP_002341963.1 450665 R 122587 CDS YP_002341964.1 218767452 906469 451547..451837 1 NC_003116.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 451837 groES 906469 groES Neisseria meningitidis Z2491 co-chaperonin GroES YP_002341964.1 451547 D 122587 CDS YP_002341965.1 218767453 906470 451930..453564 1 NC_003116.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 453564 groEL 906470 groEL Neisseria meningitidis Z2491 chaperonin GroEL YP_002341965.1 451930 D 122587 CDS YP_002341966.1 218767454 906471 complement(454152..456584) 1 NC_003116.1 NMA0474, hpuB, haemoglobin-haptoglobin-utilization protein, len: 810aa; strongly similar to many eg. SW:P96949 (U73112) hpuB,haemoglobin-haptoglobin-utilization protein from Neisseria meningitidis strain DNM2 (810 aa) fasta scores; E(): 0,96.5% identity in 810 aa overlap. Contains Pfam match to entry PF00593 TonB_boxC, TonB dependent receptor C-terminal region.; hemoglobin-haptoglobin-utilization protein 456584 906471 NMA0474 Neisseria meningitidis Z2491 hemoglobin-haptoglobin-utilization protein YP_002341966.1 454152 R 122587 CDS YP_002341967.1 218767455 906472 complement(456615..457688) 1 NC_003116.1 NMA0475, hpuA, haemoglobin-haptoglobin-utilization protein, len: 357aa; similar to many eg. TR:P96948 (EMBL:U73112) hpuA, haemoglobin-haptoglobin-utilization protein from Neisseria meningitidis strain DNM2 (341 aa) fasta scores; E(): 0, 77.4% identity in 359 aa overlap.; hemoglobin-haptoglobin-utilization protein 457688 906472 NMA0475 Neisseria meningitidis Z2491 hemoglobin-haptoglobin-utilization protein YP_002341967.1 456615 R 122587 CDS YP_002341968.1 218767456 906473 458956..460473 1 NC_003116.1 NMA0476, hypothetical periplasmic protein, len: 505aa; weakly similar to hypothetical proteins eg. TR:Q9ZF57 (EMBL:AF118122) outer membrane protein from Neisseria meningitidis (488 aa) fasta scores; E(): 5e-16, 26.3% identity in 452 aa overlap; hypothetical periplasmic protein 460473 906473 NMA0476 Neisseria meningitidis Z2491 hypothetical periplasmic protein YP_002341968.1 458956 D 122587 CDS YP_002341969.1 218767457 906474 complement(460532..462328) 1 NC_003116.1 NMA0477, para-aminobenzoate synthase component I, len: 598aa; regions similar to many eg. SW:P05041 (PABB_ECOLI) para-aminobenzoate synthase component I from Escherichia coli (453 aa) fasta scores; E(): 8.5e-29, 41.2% identity in 284 aa overlap. Contains Pfam match to entry PF01063 aminotran_4, Aminotransferase class IV and; para-aminobenzoate synthase component I 462328 906474 NMA0477 Neisseria meningitidis Z2491 para-aminobenzoate synthase component I YP_002341969.1 460532 R 122587 CDS YP_002341970.1 218767458 906475 complement(463713..466919) 1 NC_003116.1 NMA0478, outer membrane peptidase, len: 1068aa; similar to many eg. similar to a group of proteins described as outer membrane antigens or peptidases egs. SW:P31631 (SSA1_PASHA) serotype-specific antigen I from Pasteurella haemolytica (932 aa) fasta scores; E(): 5.7e-22, 26.1% identity in 509 aa overlap and SW:P09489 (PRTS_SERMA) extracellular serine protease from Serratia marcescens (1045 aa) fasta scores; E(): 1.8e-10, 23.7% identity in 1074 aa overlap. Contains two Pfam matches to entry PF00082 Peptidase_S8, Subtilase family; and Prosite match to PS00138 Serine proteases, subtilase family,serine active site.; outer membrane peptidase 466919 906475 NMA0478 Neisseria meningitidis Z2491 outer membrane peptidase YP_002341970.1 463713 R 122587 CDS YP_002341971.1 218767459 906476 complement(468118..469560) 1 NC_003116.1 NAD-linked; aldehyde dehydrogenase 469560 aldA 906476 aldA Neisseria meningitidis Z2491 aldehyde dehydrogenase YP_002341971.1 468118 R 122587 CDS YP_002341972.1 218767460 906477 complement(469595..469795) 1 NC_003116.1 NMA0481, unknown, len: 66 aa; hypothetical protein 469795 906477 NMA0481 Neisseria meningitidis Z2491 hypothetical protein YP_002341972.1 469595 R 122587 CDS YP_002341973.1 218767461 906478 complement(469804..470193) 1 NC_003116.1 NMA0482, unknown, len: 129 aa; hypothetical protein 470193 906478 NMA0482 Neisseria meningitidis Z2491 hypothetical protein YP_002341973.1 469804 R 122587 CDS YP_002341974.1 218767462 906479 complement(470401..471318) 1 NC_003116.1 NMA0483, transcriptional regulator, len: 305aa; C-terminal region weakly similar to that of many eg. SW:Q00753 (MSMR_STRMU) msm operon regulatory protein from Streptococcus mutans (278 aa) fasta scores; E(): 9.4e-05, 30.2% identity in 96 aa overlap. Contains Pfam match to entry PF00165 HTH_2, Bacterial regulatory helix-turn-helix proteins, araC family and Prosite match to PS00041 Bacterial regulatory proteins, araC family signature.; transcriptional regulator 471318 906479 NMA0483 Neisseria meningitidis Z2491 transcriptional regulator YP_002341974.1 470401 R 122587 CDS YP_002341975.1 218767463 906480 471431..472291 1 NC_003116.1 NMA0485, probable ABC transport ATP-binding subunit, len: 286aa; similar to many eg. TR:Q9Z402 (EMBL:AF106002) toluene tolerance protein from Pseudomonas putida (269 aa) fasta scores; E(): 0, 50.8% identity in 260 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter; Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00211 ABC transporters family signature.; ABC transporter ATP binding protein 472291 906480 NMA0485 Neisseria meningitidis Z2491 ABC transporter ATP binding protein YP_002341975.1 471431 D 122587 CDS YP_002341976.1 218767464 906481 472339..473115 1 NC_003116.1 NMA0486, ABC transport inner membrane subunit, len: 258aa; similar to many eg. TR:Q9Z401 (EMBL:AF106002) toluene tolerance protein from Pseudomonas putida (265 aa) fasta scores; E(): 0, 51.0% identity in 255 aa overlap. Lies downstream from an ABC transport ATP-binding subunit (NMA0485) and contains membrane-spanning hydrophobic regions.; ABC transporter inner membrane protein 473115 906481 NMA0486 Neisseria meningitidis Z2491 ABC transporter inner membrane protein YP_002341976.1 472339 D 122587 CDS YP_002341977.1 218767465 906482 473166..473660 1 NC_003116.1 NMA0487, outer membrane transport protein,len: 164aa; similar to many eg. TR:Q9Z400 (EMBL:AF106002) toluene tolerance protein from Pseudomonas putida (161 aa) fasta scores; E(): 1.3e-19, 51.7% identity in 147 aa overlap. Appears to lie in an operon downstream of an ABC transporter (NMA0485 and NMA0486). Contains Contains a cleavable N-terminal signal sequence and membrane-spanning hydrophobic regions.; outer membrane transport protein 473660 906482 NMA0487 Neisseria meningitidis Z2491 outer membrane transport protein YP_002341977.1 473166 D 122587 CDS YP_002341978.1 218767466 906483 473697..474287 1 NC_003116.1 NMA0488, periplasmic transport protein,len: 196aa; weakly similar to many eg. TR:Q9Z3Z9 (EMBL:AF106002) toluene tolerance protein from Pseudomonas putida (215 aa) fasta scores; E(): 0.0041, 24.2% identity in 211 aa overlap. Contains a cleavable N-terminal signal sequence and appears to lie in a transport operon.; periplasmic transport protein 474287 906483 NMA0488 Neisseria meningitidis Z2491 periplasmic transport protein YP_002341978.1 473697 D 122587 CDS YP_002341979.1 218767467 906484 474320..474622 1 NC_003116.1 NMA0489, hypothetical protein, len: 100aa; similar to SW:Q57407 (YA83_HAEIN) hypothetical protein from Haemophilus influenzae (105 aa) fasta scores; E(): 0.65,29.5% identity in 88 aa overlap.; hypothetical protein 474622 906484 NMA0489 Neisseria meningitidis Z2491 hypothetical protein YP_002341979.1 474320 D 122587 CDS YP_002341980.1 218767468 906485 474619..475458 1 NC_003116.1 NMA0490, periplasmic/outer membrane protein, len: 279aa; similar to many eg. SW:P43262 (VACJ_SHIFL) lipoprotein required for intercellular spreading of Shigella flexneri (251 aa) fasta scores; E(): 1.8e-14, 31.7% identity in 221 aa overlap. Seems to have a cleavable N-term signal seq.; periplasmic/outer membrane protein 475458 906485 NMA0490 Neisseria meningitidis Z2491 periplasmic/outer membrane protein YP_002341980.1 474619 D 122587 CDS YP_002341981.1 218767469 906486 475463..475945 1 NC_003116.1 NMA0491, hypothetical protein, len: 160aa; hypothetical protein 475945 906486 NMA0491 Neisseria meningitidis Z2491 hypothetical protein YP_002341981.1 475463 D 122587 CDS YP_002341982.1 218767470 906487 475945..476328 1 NC_003116.1 NMA0492, conserved hypothetical protein, len: 127aa; similar to many eg. SW:P77712 (YBAW_ECOLI) hypothetical protein from Escherichia coli (132 aa) fasta scores; E(): 3.1e-15, 40.2% identity in 127 aa overlap.; hypothetical protein 476328 906487 NMA0492 Neisseria meningitidis Z2491 hypothetical protein YP_002341982.1 475945 D 122587 CDS YP_002341983.1 218767471 906488 476325..476813 1 NC_003116.1 NMA0493, periplasmic protein, len: 162aa; similar to many of undefined function eg. TR:O66542 (EMBL:AE000675) from Aquifex aeolicus (146 aa) fasta scores; E(): 1.3e-06, 32.0% identity in 128 aa overlap. Contains a cleavable N-terminal signal sequence.; hypothetical protein 476813 906488 NMA0493 Neisseria meningitidis Z2491 hypothetical protein YP_002341983.1 476325 D 122587 CDS YP_002341984.1 218767472 906489 complement(476895..477407) 1 NC_003116.1 NMA0494, acetyltransferase, len: 170aa; similar to many eg. SW:P07464 (THGA_ECOLI) thiogalactoside transacetylase from Escherichia coli (203 aa) fasta scores; E(): 6.3e-10, 32.1% identity in 140 aa overlap. Contains two Pfam match to entry PF00132 hexapep,Bacterial transferase hexapeptide (four repeats).; acetyltransferase 477407 906489 NMA0494 Neisseria meningitidis Z2491 acetyltransferase YP_002341984.1 476895 R 122587 CDS YP_002341985.1 218767473 906490 477642..477857 1 NC_003116.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 477857 rpmE 906490 rpmE Neisseria meningitidis Z2491 50S ribosomal protein L31 YP_002341985.1 477642 D 122587 CDS YP_002341986.1 218767474 906491 478160..478801 1 NC_003116.1 NMA0496, cad, cadmium resistance protein, len: 213aa; strongly similar to TR:O05469 (EMBL:U76550) cadD,cadmium resistance protein from Staphylococcus aureus (209 aa) fasta scores; E(): 0, 55.5% identity in 209 aa overlap. Lies in a region of unusually low GC content.; cadmium resistance protein 478801 906491 NMA0496 Neisseria meningitidis Z2491 cadmium resistance protein YP_002341986.1 478160 D 122587 CDS YP_002341987.1 218767475 906492 478957..480633 1 NC_003116.1 NMA0497, probable inner membrane protein, len: 558aa; similar to many eg. TR:P76473 (EMBL:AE000315) hypothetical protein from Escherichia coli (550 aa) fasta scores; E(): 5.4e-05, 25.1% identity in 379 aa overlap. Contains membrane-spanning hydrophobic regions.; inner membrane protein 480633 906492 NMA0497 Neisseria meningitidis Z2491 inner membrane protein YP_002341987.1 478957 D 122587 CDS YP_002341988.1 218767476 906493 480735..481340 1 NC_003116.1 NMA0498, regF, probable regulator of pilE expression, len: 201aa; similar to TR:O33374 (EMBL:X99693) regF, regulator of pilE expression from Neisseria gonorrhoeae (201 aa) fasta scores; E(): 0, 98.0% identity in 201 aa overlap and SW:P05838 (SSPA_ECOLI) stringent starvation protein A from Escherichia coli (211 aa) fasta scores; E(): 3.3e-32, 45.8% identity in 201 aa overlap. Also similar to many glutathione transferases eg. TR:O24595 (EMBL:Y12862) glutathione transferase from Zea mays (Maize) (224 aa) fasta scores; E(): 2.3e-13, 32.3% identity in 195 aa overlap. Contains Pfam match to entry PF00043 GST, Glutathione S-transferases.; regulator of pilE expression 481340 906493 NMA0498 Neisseria meningitidis Z2491 regulator of pilE expression YP_002341988.1 480735 D 122587 CDS YP_002341989.1 218767477 906494 481412..481804 1 NC_003116.1 NMA0499, regG, regulator of pilE expression, may act in concert with regF (NMA0498) len: 130aa; similar to TR:O33375 (EMBL:X99693) regG (FRAGMENT), regulator of pilE expression from Neisseria gonorrhoeae (65 aa) fasta scores; E(): 2.6e-25, 98.5% identity in 65 aa overlap and SW:P25663 (SSPB_ECOLI) stringent starvation protein B from Escherichia coli (165 aa) fasta scores; E(): 6.7e-17, 46.6% identity in 118 aa overlap.; ClpXP protease specificity-enhancing factor 481804 regG 906494 regG Neisseria meningitidis Z2491 ClpXP protease specificity-enhancing factor YP_002341989.1 481412 D 122587 CDS YP_002341990.1 218767478 906496 complement(482129..482575) 1 NC_003116.1 NMA0501, conserved hypothetical protein, len: 148aa; similar to many eg. TR:P71480 (EMBL:U63641) hypothetical protein from Legionella pneumophila (146 aa) fasta scores; E(): 1.3e-19, 46.3% identity in 147 aa overlap.; hypothetical protein 482575 906496 NMA0501 Neisseria meningitidis Z2491 hypothetical protein YP_002341990.1 482129 R 122587 CDS YP_002341991.1 218767479 906497 complement(482707..482919) 1 NC_003116.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 482919 rpsU 906497 rpsU Neisseria meningitidis Z2491 30S ribosomal protein S21 YP_002341991.1 482707 R 122587 CDS YP_002341992.1 218767480 906498 complement(483208..485058) 1 NC_003116.1 NMA0503, transglycosylase, len: 616aa; weakly similar to many eg. SW:P03810 (SLT_ECOLI) soluble lytic transglycosylase from Escherichia coli (645 aa) fasta scores; E(): 9.8e-21, 24.8% identity in 592 aa overlap. Contains Pfam match to entry PF01464 SLT,Transglycosylase SLT domain and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; transglycosylase 485058 906498 NMA0503 Neisseria meningitidis Z2491 transglycosylase YP_002341992.1 483208 R 122587 CDS YP_002341993.1 218767481 906499 485588..486325 1 NC_003116.1 NMA0504, probable ABC transport ATP-binding subunit, len: 249aa; similar to many eg. SW:P30750 (ABC_ECOLI) ATP-binding protein ABC from Escherichia coli (343 aa) fasta scores; E(): 0, 50.6% identity in 243 aa overlap. Contains Pfam match to entry PF00005 ABC_tran,ABC transporter; Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00211 ABC transporters family signature.; ABC transporter ATP-binding protein 486325 906499 NMA0504 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002341993.1 485588 D 122587 CDS YP_002341994.1 218767482 906500 486327..487013 1 NC_003116.1 NMA0505, probable inner membrane transport protein,len: 228aa; similar to many eg. SW:P31547 (YAEE_ECOLI) hypothetical ABC transporter permease from Escherichia coli (217 aa) fasta scores; E(): 7e-28, 43.1% identity in 209 aa overlap. Lies immediately downstream of a ABC transport ATP-binding subunit and contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component.; inner membrane transport protein 487013 906500 NMA0505 Neisseria meningitidis Z2491 inner membrane transport protein YP_002341994.1 486327 D 122587 CDS YP_002341995.1 218767483 906501 487103..487966 1 NC_003116.1 NMA0506, lipoprotein, len: 287aa; similar to many eg. SW:P28635 (YAEC_ECOLI) hypothetical lipoprotein from Escherichia coli (271 aa) fasta scores; E(): 4.7e-27, 39.4% identity in 277 aa overlap. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein 487966 906501 NMA0506 Neisseria meningitidis Z2491 lipoprotein YP_002341995.1 487103 D 122587 CDS YP_002341996.1 218767484 906502 complement(488028..488597) 1 NC_003116.1 NMA0507, probable decarboxylase, len: 189aa; similar to many eg. SW:P33751 (PAD1_YEAST) phenylacrylic acid decarboxylase from Saccharomyces cerevisiae (Baker's yeast) (242 aa) fasta scores; E(): 1e-30, 42.2% identity in 185 aa overlap.; aromatic acid decarboxylase 488597 906502 NMA0507 Neisseria meningitidis Z2491 aromatic acid decarboxylase YP_002341996.1 488028 R 122587 CDS YP_002341997.1 218767485 906503 488755..489615 1 NC_003116.1 NMA0508, chromosome segregation proteins,len: 286aa; similar to many eg. SW:P26497 (SP0J_BACSU) stage 0 sporulation protein from Bacillus subtilis (282 aa) fasta scores; E(): 0, 41.3% identity in 286 aa overlap. Contains helix-turn-helix motifs 132-153aa (+5.12 SD) and 143-164aa (+5.01 SD).; chromosome segregation proteins 489615 906503 NMA0508 Neisseria meningitidis Z2491 chromosome segregation proteins YP_002341997.1 488755 D 122587 CDS YP_002341998.1 218767486 906504 489750..490088 1 NC_003116.1 NMA0510, hypothetical protein, len: 112aa; contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a helix-turn-helix motif 32-53aa (+2.63 SD).; hypothetical protein 490088 906504 NMA0510 Neisseria meningitidis Z2491 hypothetical protein YP_002341998.1 489750 D 122587 CDS YP_002341999.1 218767487 906505 490197..490961 1 NC_003116.1 NMA0511, insertion element IS1655 transposase, len: 254aa; similar to many eg. SW:P37247 (TRA4_BACFR) insertion element IS4351 transposase from Bacteroides fragilis (326 aa) fasta scores; E(): 3e-29, 38.5% identity in 252 aa overlap. Also similar to many others on this chromosome eg. NMA1486 (fasta scores; E(): 0, 100.0% identity in 254 aa overlap). Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family. Contains helix-turn-helix motif 22-43aa (+4.99 SD).; insertion element IS1655 transposase 490961 906505 NMA0511 Neisseria meningitidis Z2491 insertion element IS1655 transposase YP_002341999.1 490197 D 122587 CDS YP_002342000.1 218767488 906506 491540..491893 1 NC_003116.1 NMA0512, atpI, probable ATP synthase I, inner membrane protein, len: 117aa; weakly similar to many eg. SW:P03808 (ATPZ_ECOLI) atpI, probable ATP synthase I from Escherichia coli (125 aa) fasta scores; E(): 0.93, 25.5% identity in 102 aa overlap. Contains membrane-spanning hydrophobic regions.; ATP synthase I 491893 906506 NMA0512 Neisseria meningitidis Z2491 ATP synthase I YP_002342000.1 491540 D 122587 CDS YP_002342001.1 218767489 906507 491883..492749 1 NC_003116.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 492749 atpB 906507 atpB Neisseria meningitidis Z2491 F0F1 ATP synthase subunit A YP_002342001.1 491883 D 122587 CDS YP_002342002.1 218767490 906508 492806..493042 1 NC_003116.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 493042 atpE 906508 atpE Neisseria meningitidis Z2491 F0F1 ATP synthase subunit C YP_002342002.1 492806 D 122587 CDS YP_002342003.1 218767491 906509 493113..493583 1 NC_003116.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 493583 atpF 906509 atpF Neisseria meningitidis Z2491 F0F1 ATP synthase subunit B YP_002342003.1 493113 D 122587 CDS YP_002342004.1 218767492 906510 493588..494121 1 NC_003116.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 494121 atpH 906510 atpH Neisseria meningitidis Z2491 F0F1 ATP synthase subunit delta YP_002342004.1 493588 D 122587 CDS YP_002342005.1 218767493 906511 494132..495679 1 NC_003116.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 495679 atpA 906511 atpA Neisseria meningitidis Z2491 F0F1 ATP synthase subunit alpha YP_002342005.1 494132 D 122587 CDS YP_002342006.1 218767494 906512 495704..496579 1 NC_003116.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 496579 atpG 906512 atpG Neisseria meningitidis Z2491 F0F1 ATP synthase subunit gamma YP_002342006.1 495704 D 122587 CDS YP_002342007.1 218767495 906513 496617..498014 1 NC_003116.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 498014 atpD 906513 atpD Neisseria meningitidis Z2491 F0F1 ATP synthase subunit beta YP_002342007.1 496617 D 122587 CDS YP_002342008.1 218767496 906514 498025..498447 1 NC_003116.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 498447 atpC 906514 atpC Neisseria meningitidis Z2491 F0F1 ATP synthase subunit epsilon YP_002342008.1 498025 D 122587 CDS YP_002342009.1 218767497 906515 498802..499707 1 NC_003116.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 499707 glyQ 906515 glyQ Neisseria meningitidis Z2491 glycyl-tRNA synthetase subunit alpha YP_002342009.1 498802 D 122587 CDS YP_002342010.1 218767498 906516 499784..500194 1 NC_003116.1 NMA0522, hypothetical protein, len: 136aa; similar to SW:P44649 (YGGL_HAEIN) hypothetical protein from Haemophilus influenzae (114 aa) fasta scores; E(): 0.015,32.1% identity in 106 aa overlap.; hypothetical protein 500194 906516 NMA0522 Neisseria meningitidis Z2491 hypothetical protein YP_002342010.1 499784 D 122587 CDS YP_002342011.1 218767499 906517 500215..502278 1 NC_003116.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 502278 glyS 906517 glyS Neisseria meningitidis Z2491 glycyl-tRNA synthetase subunit beta YP_002342011.1 500215 D 122587 CDS YP_002342012.1 218767500 906518 502343..503383 1 NC_003116.1 NMA0524, lgtA, lacto-N-neotetraose biosynthesis glycosyl tranferase, len: 346 aa; highly similar to TR:Q51115 (EMBL:U25839), lgtA, Neisseria meningitidis lacto-N-neotetraose biosynthesis glycosyl tranferase (333 aa), fasta scores; E(): 0, 94.3% identity in 333 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; lacto-N-neotetraose biosynthesis glycosyl transferase 503383 906518 NMA0524 Neisseria meningitidis Z2491 lacto-N-neotetraose biosynthesis glycosyl transferase YP_002342012.1 502343 D 122587 CDS YP_002342013.1 218767501 906519 503383..504222 1 NC_003116.1 NMA0525, lgtB, lacto-N-neotetraose biosynthesis glycosyl tranferase, len:279 aa; highly similar to SW:LGTB_NEIME (EMBL:U25839), lgtB, Neisseria meningitidis MC58 lacto-N-neotetraose biosynthesis glycosyl tranferase (275 aa), fasta scores; E(): 0, 92.5% identity in 279 aa overlap. Highly similar to NMA0527, fasta scores; E(): 0,75.7% identity in 280 aa overlap; lacto-N-neotetraose biosynthesis glycosyl transferase 504222 906519 NMA0525 Neisseria meningitidis Z2491 lacto-N-neotetraose biosynthesis glycosyl transferase YP_002342013.1 503383 D 122587 CDS YP_002342014.1 218767502 906521 504371..505177 1 NC_003116.1 NMA0527, lgtB2, lacto-N-neotetraose biosynthesis glycosyl tranferase, len: 268 aa; highly similar to SW:LGTB_NEIME (EMBL:U25839), lgtB, Neisseria meningitidis MC58 lacto-N-neotetraose biosynthesis glycosyl tranferase (275 aa), fasta scores; E(): 0, 72.9% identity in 280 aa overlap. Highly similar to NMA0525, fasta scores; E(): 0,75.7% identity in 280 aa overlap; lacto-N-neotetraose biosynthesis glycosyl transferase 505177 906521 NMA0527 Neisseria meningitidis Z2491 lacto-N-neotetraose biosynthesis glycosyl transferase YP_002342014.1 504371 D 122587 CDS YP_002342015.1 218767503 906522 complement(507126..507851) 1 NC_003116.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 507851 906522 NMA0528 Neisseria meningitidis Z2491 16S ribosomal RNA methyltransferase RsmE YP_002342015.1 507126 R 122587 CDS YP_002342016.1 218767504 906523 508060..508854 1 NC_003116.1 NMA0529, len: 264 aa; unknown, similar to SW:SUHB_ECOLI (EMBL:M34828), suhB, Escherichia coli protein which affects sigma 32 synthesis (267 aa), fasta scores; E(): 4e-18, 34.8% identity in 184 aa overlap and to homologues from other bacteria. Also similar to eukaryotic myo-inositol-1(or 4)-monophosphatases e.g. SW:MYOP_RAT (EMBL:U84038), impA1, Rattus norvegicus myo-inositol-1(or 4)-monophosphatase (277 aa), fasta scores; E(): 4.2e-17, 34.8% identity in 204 aa overlap. Also similar to NMA1559, fasta scores; E(): 5e-19, 35.2% identity in 179 aa overlap. Contains Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family and PS00629 Inositol monophosphatase family signature 1; hypothetical protein 508854 906523 NMA0529 Neisseria meningitidis Z2491 hypothetical protein YP_002342016.1 508060 D 122587 CDS YP_002342017.1 218767505 906529 complement(512369..513115) 1 NC_003116.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 513115 fabG 906529 fabG Neisseria meningitidis Z2491 3-ketoacyl-ACP reductase YP_002342017.1 512369 R 122587 CDS YP_002342018.1 218767506 906530 complement(513177..514742) 1 NC_003116.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 514742 guaA 906530 guaA Neisseria meningitidis Z2491 GMP synthase YP_002342018.1 513177 R 122587 CDS YP_002342019.1 218767507 906531 complement(514842..516707) 1 NC_003116.1 NMA0535, probable ABC transporter ATP-binding protein, len: 621 aa; similar to many e.g. SW:MSBA_ECOLI (EMBL:Z11796), msbA, Escherichia coli essential ABC transporter involved in lipid A and phospholipid biosynthesis (582 aa), fasta scores; E(): 0, 35.2% identity in 597 aa overlap. Contains Pfam matches to entry PF00664 ABC_membrane, ABC transporter transmembrane region and to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Contains hydrophobic, probable membrane-spanning regions; ABC transporter ATP-binding protein 516707 906531 NMA0535 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002342019.1 514842 R 122587 CDS YP_002342020.1 218767508 906532 complement(516845..517771) 1 NC_003116.1 NMA0536, fabD, probable malonyl CoA-acyl carrier protein transacylase, len: 308 aa; similar to many e.g. SW:FABD_ECOLI (EMBL:M87040), fabD, Escherichia coli malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (308 aa), fasta scores; E(): 0, 57.0% identity in 305 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain; malonyl CoA-acyl carrier protein transacylase 517771 906532 NMA0536 Neisseria meningitidis Z2491 malonyl CoA-acyl carrier protein transacylase YP_002342020.1 516845 R 122587 CDS YP_002342021.1 218767509 906533 complement(517957..518322) 1 NC_003116.1 NMA0537, integral membrane protein, len: 121 aa; unknown, in part similar to TR:P94519 (EMBL:Z75208), ysdA, Bacillus subtilis hypothetical protein (89 aa), fasta scores; E(): 3.1e-05, 39.3% identity in 84 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein 518322 906533 NMA0537 Neisseria meningitidis Z2491 integral membrane protein YP_002342021.1 517957 R 122587 CDS YP_002342022.1 218767510 906534 complement(518369..519331) 1 NC_003116.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 519331 fabH 906534 fabH Neisseria meningitidis Z2491 3-oxoacyl-ACP synthase YP_002342022.1 518369 R 122587 CDS YP_002342023.1 218767511 906535 complement(519581..520006) 1 NC_003116.1 NMA0540, len: 141 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 520006 906535 NMA0540 Neisseria meningitidis Z2491 hypothetical protein YP_002342023.1 519581 R 122587 CDS YP_002342024.1 218767512 906536 complement(520024..520275) 1 NC_003116.1 NMA0541, len: 83 aa, unknown, lies within a region of unusually low GC content; hypothetical protein 520275 906536 NMA0541 Neisseria meningitidis Z2491 hypothetical protein YP_002342024.1 520024 R 122587 CDS YP_002342025.1 218767513 906537 complement(520411..521466) 1 NC_003116.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 521466 plsX 906537 plsX Neisseria meningitidis Z2491 glycerol-3-phosphate acyltransferase PlsX YP_002342025.1 520411 R 122587 CDS YP_002342026.1 218767514 906538 complement(521554..522081) 1 NC_003116.1 NMA0543, len: 175 aa; shows very weak similarity to TR:P74916 (EMBL:D37928), gpt, Thermus aquaticus purine phosphoribosyltransferase (154 aa), fasta scores; E(): 8.7e-05, 27.8% identity in 158 aa overlap and to hypothetical proteins e.g. TR:CAB49024 (EMBL:AJ248283) purine phosphoribosyltransferase related protein (153 aa),fasta scores; E(): 2.5e-09, 30.1% identity in 163 aa overlap; hypothetical protein 522081 906538 NMA0543 Neisseria meningitidis Z2491 hypothetical protein YP_002342026.1 521554 R 122587 CDS YP_002342027.1 218767515 906539 complement(522409..522588) 1 NC_003116.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 522588 rpmF 906539 rpmF Neisseria meningitidis Z2491 50S ribosomal protein L32 YP_002342027.1 522409 R 122587 CDS YP_002342028.1 218767516 906540 complement(522622..523125) 1 NC_003116.1 NMA0545, len: 167 aa; unknown, shows weak similarity to SW:YCED_ECOLI (EMBL:M29698), yceD,Escherichia coli hypothetical protein (17=3 aa), fasta scores; E(): 1.3e-07, 32.0% identity in 172 aa overlap and SW:YCED_HAEIN (EMBL:U20229), HI0159, Haemophilus influenzae hypothetical protein (174 aa), fasta scores; E(): 4.5e-06,30.6% identity in 173 aa overlap; hypothetical protein 523125 906540 NMA0545 Neisseria meningitidis Z2491 hypothetical protein YP_002342028.1 522622 R 122587 CDS YP_002342029.1 218767517 906541 523273..523863 1 NC_003116.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 523863 maf 906541 maf Neisseria meningitidis Z2491 Maf-like protein YP_002342029.1 523273 D 122587 CDS YP_002342030.1 218767518 906542 523910..524635 1 NC_003116.1 NMA0547, len: 241 aa; unknown, similar to many hypothetical proteins e.g. SW:YRAL_ECOLI (EMBL:U18997),yraL, Escherichia coli hypothetical protein (286 aa),fasta scores; E(): 5.6e-14, 31.1% identity in 235 aa overlap. Also similar to NMA0342, fasta scores; E(): 1.6e-14, 30.4% identity in 217 aa overlap; hypothetical protein 524635 906542 NMA0547 Neisseria meningitidis Z2491 hypothetical protein YP_002342030.1 523910 D 122587 CDS YP_002342031.1 218767519 906543 complement(524716..526353) 1 NC_003116.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 526353 906543 NMA0548 Neisseria meningitidis Z2491 inner membrane protein translocase component YidC YP_002342031.1 524716 R 122587 CDS YP_002342032.1 218767520 906544 complement(526525..526815) 1 NC_003116.1 NMA0549, len: 96 aa; unknown, similar to hypothetical proteins found downstream of rnpA and elsewhere in many bacteria e.g. SW:YIDD_ECOLI (EMBL:M11056), yidD, Escherichia coli hypothetical protein (85 aa), fasta scores; E(): 3.1e-14, 52.9% identity in 68 aa overlap. Also similar to TR:Q44066 (EMBL:L36462), hlyA,Aeromonas hydrophila haemolysin (85 aa), fasta scores; E(): 3.1e-14, 52.9% identity in 68 aa overlap. GC frameplot suggests a start codon overlapping the stop codon of rnpA. However, similarity to other sequences suggests a start codon at codon 24 or 28. The true position is therefore uncertain; hypothetical protein 526815 906544 NMA0549 Neisseria meningitidis Z2491 hypothetical protein YP_002342032.1 526525 R 122587 CDS YP_002342033.1 218767521 906545 complement(526812..527177) 1 NC_003116.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 527177 rnpA 906545 rnpA Neisseria meningitidis Z2491 ribonuclease P YP_002342033.1 526812 R 122587 CDS YP_002342034.1 218767522 906546 complement(527180..527314) 1 NC_003116.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 527314 rpmH 906546 rpmH Neisseria meningitidis Z2491 50S ribosomal protein L34 YP_002342034.1 527180 R 122587 CDS YP_002342035.1 218767523 906547 527602..529158 1 NC_003116.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 529158 dnaA 906547 dnaA Neisseria meningitidis Z2491 chromosomal replication initiation protein YP_002342035.1 527602 D 122587 CDS YP_002342036.1 218767524 906548 529238..530341 1 NC_003116.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 530341 dnaN 906548 dnaN Neisseria meningitidis Z2491 DNA polymerase III subunit beta YP_002342036.1 529238 D 122587 CDS YP_002342037.1 218767525 906549 complement(530526..531119) 1 NC_003116.1 NMA0554, transposase for IS1016, len: 197 aa; similar to many e.g. TR:Q48234 (EMBL:X59756) ORF from Haemophilus influenzae insertion sequence IS1016-V6 (191 aa), fasta scores; E(): 0, 69.7% identity in 175 aa overlap; transposase for IS1016 531119 906549 NMA0554 Neisseria meningitidis Z2491 transposase for IS1016 YP_002342037.1 530526 R 122587 CDS YP_002342038.1 218767526 906550 complement(531352..533409) 1 NC_003116.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 533409 ppk 906550 ppk Neisseria meningitidis Z2491 polyphosphate kinase YP_002342038.1 531352 R 122587 CDS YP_002342039.1 218767527 906551 complement(533578..534021) 1 NC_003116.1 NMA0556, periplasmic protein, len: 147 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein 534021 906551 NMA0556 Neisseria meningitidis Z2491 hypothetical protein YP_002342039.1 533578 R 122587 CDS YP_002342040.1 218767528 906552 complement(534028..534543) 1 NC_003116.1 NMA0557, mlp, lipoprotein, len: 171 aa; highly similar to TR:Q51103 (EMBL:U16284), mlp, Neisseria meningitidis BNCV lipoprotein not expressed by Neisseria gonorrhoeae (171 aa), fasta scores; E(): 0, 97.1% identity in 171 aa overlap. Contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 534543 906552 NMA0557 Neisseria meningitidis Z2491 lipoprotein YP_002342040.1 534028 R 122587 CDS YP_002342041.1 218767529 906553 534813..537545 1 NC_003116.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 537545 leuS 906553 leuS Neisseria meningitidis Z2491 leucyl-tRNA synthetase YP_002342041.1 534813 D 122587 CDS YP_002342042.1 218767530 906554 537775..538566 1 NC_003116.1 NMA0560, drg, probable type II restriction endonuclease, len: 263 aa; similar to SW:T2D1_STRPN (EMBL:M14340), dpnC, Streptococcus pneumoniae type II restriction endonuclease (254 aa), fasta scores; E(): 0,43.4% identity in 256 aa overlap. Highly similar to TR:AAD34293 (EMBL:AF091143), drg, Neisseria meningitidis BL2 endonuclease (254 aa), fasta scores; E(): 0,100.0% identity in 252 aa overlap. Lies within a region of unusually low GC content; type II restriction endonuclease 538566 906554 NMA0560 Neisseria meningitidis Z2491 type II restriction endonuclease YP_002342042.1 537775 D 122587 CDS YP_002342043.1 218767531 906556 538898..539779 1 NC_003116.1 NMA0562, len: 293 aa; unknown, shows weak similarity, except at the N-terminus, to hypothetical proteins from bacteria and yeast e.g. SW:YGGG_ECOLI (EMBL:M32363), yggG, Escherichia coli hypothetical protein (252 aa), fasta scores; E(): 1.3e-07 23.4% identity in 256 aa overlap. The predicted start codon is uncertain; fasta similarities and GC frameplot suggest that the start codon would be at approx. codon 17 where a potential signal sequence and lipoprotein attachment site would then be predicted. As no candidate sites are present, the nearest upstream alternative has been used. Lies within a region of unusually low GC content; hypothetical protein 539779 906556 NMA0562 Neisseria meningitidis Z2491 hypothetical protein YP_002342043.1 538898 D 122587 CDS YP_002342044.1 218767532 906558 complement(540161..540472) 1 NC_003116.1 NMA0564, DNA-binding protein, len: 103 aa; unknown, similar to TR:Q57459 (EMBL:X75356) Coxiella burnetii plasmid QpH1 hypothetical protein (114 aa), fasta scores; E(): 3.5e-15, 49.0% identity in 96 aa overlap. Contains Pfam match to entry PF01381 HTH_3,Helix-turn-helix. Contains probable helix-turn-helix motif at aa 58-79 (Score 1781, +5.25 SD); DNA-binding protein 540472 906558 NMA0564 Neisseria meningitidis Z2491 DNA-binding protein YP_002342044.1 540161 R 122587 CDS YP_002342045.1 218767533 906559 complement(540469..540837) 1 NC_003116.1 NMA0565, len: 122 aa; unknown, similar to TR:Q45933 (EMBL:X85964) Coxiella burnetii plasmid QpDV hypothetical protein (121 aa), fasta scores; E(): 3.5e-14, 39.2% identity in 120 aa overlap; hypothetical protein 540837 906559 NMA0565 Neisseria meningitidis Z2491 hypothetical protein YP_002342045.1 540469 R 122587 CDS YP_002342046.1 218767534 906562 complement(541736..542086) 1 NC_003116.1 NMA0569, secG, probable protein-export integral membrane protein, len: 116 aa; similar to SW:SECG_ECOLI (EMBL:D16463), secG, Escherichia coli protein-export membrane protein (110 aa), fasta scores; E(): 2.9e-09,38.6% identity in 101 aa overlap. Contains a probable N-terminal signal sequence and a hydrophobic, probable membrane-spanning region; preprotein translocase subunit SecG 542086 secG 906562 secG Neisseria meningitidis Z2491 preprotein translocase subunit SecG YP_002342046.1 541736 R 122587 CDS YP_002342047.1 218767535 906563 complement(542093..542848) 1 NC_003116.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 542848 tpiA 906563 tpiA Neisseria meningitidis Z2491 triosephosphate isomerase YP_002342047.1 542093 R 122587 CDS YP_002342048.1 218767536 906564 543026..543553 1 NC_003116.1 NMA0571, len: 175 aa; unknown, similar to hypothetical proteins from bacteria and eukaryotes e.g. SW:YKG9_YEAST (EMBL:X75780), YKL069W, Saccharomyces cerevisiae hypothetical protein (180 aa), fasta scores; E(): 1.3e-20, 37.7% identity in 167 aa overlap and SW:YEBR_ECOLI (EMBL:AE000277), yebR, Escherichia coli hypothetical protein (183 aa), fasta scores; E(): 1.4e-20,44.0% identity in 150 aa overlap; hypothetical protein 543553 906564 NMA0571 Neisseria meningitidis Z2491 hypothetical protein YP_002342048.1 543026 D 122587 CDS YP_002342049.1 218767537 906565 543655..544311 1 NC_003116.1 NMA0572, probable protein-L-isoaspartate O-methyltransferase, len: 218 aa; similar to many e.g. SW:PIMT_ECOLI (EMBL:M63493), pcm, Escherichia coli protein-L-isoaspartate O-methyltransferase (EC 2.1.1.77) (207 aa), fasta scores; E(): 1.5e-17, 38.7% identity in 186 aa overlap. Contains Pfam match to entry PF01135 PCMT,Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); protein-L-isoaspartate O-methyltransferase 544311 906565 NMA0572 Neisseria meningitidis Z2491 protein-L-isoaspartate O-methyltransferase YP_002342049.1 543655 D 122587 CDS YP_002342050.1 218767538 906566 544391..544714 1 NC_003116.1 NMA0573, len: 107 aa; unknown, shows weak similarity SW:GLPE_ECOLI (EMBL:M96795), glpE, Escherichia coli protein of unknown function (108 aa), fasta scores; E(): 4.6e-06, 31.8% identity in 85 aa overlap and to other hypothetical protein of similar length. Also shows weak similarity to the C-termini of longer hypothetical proteins e.g. TR:O05860 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical protein (392 aa), fasta scores; E(): 8.9e-10, 39.0% identity in 100 aa overlap. Contains Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain; hypothetical protein 544714 906566 NMA0573 Neisseria meningitidis Z2491 hypothetical protein YP_002342050.1 544391 D 122587 CDS YP_002342051.1 218767539 906568 complement(545129..547306) 1 NC_003116.1 NMA0575, probable ferric siderophore receptor protein, len: 725 aa; similar to many ferric siderophore receptors e.g. TR:AAD26430 (EMBL:AF135154), fauA,Bordetella pertussis FERRIC alcaligin siderophore receptor (734 aa), fasta scores; E(): 0, 33.1% identity in 721 aa overlap. Contains Pfam match to entry PF00593 TonB_boxC,TonB dependent receptor C-terminal region. Contains a probable N-terminal signal sequence; ferric siderophore receptor protein 547306 906568 NMA0575 Neisseria meningitidis Z2491 ferric siderophore receptor protein YP_002342051.1 545129 R 122587 CDS YP_002342052.1 218767540 906569 complement(547420..547743) 1 NC_003116.1 NMA0576, len: 107 aa; unknown, shows weak similarity to TR:P96597 (EMBL:AB001488), ydbB, Bacillus subtilis hypothetical protein (113 aa), fasta scores; E(): 2.7e-05, 33.3% identity in 66 aa overlap; hypothetical protein 547743 906569 NMA0576 Neisseria meningitidis Z2491 hypothetical protein YP_002342052.1 547420 R 122587 CDS YP_002342053.1 218767541 906570 complement(548781..549746) 1 NC_003116.1 NMA0577, fetB2, probable ferric enterobactin transporter binding protein, len: 321 aa; similar to TR:AAD29611 (EMBL:AF115385), fetB, Neisseria gonorrhoeae ferric enterobactin transporter periplasmic binding protein (323 aa), fasta scores; E(): 0, 50.6% identity in 314 aa overlap. Contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Similar to NMA0452, fasta scores; E(): 0, 50.0% identity in 314 aa overlap; ferric enterobactin transporter binding protein 549746 906570 NMA0577 Neisseria meningitidis Z2491 ferric enterobactin transporter binding protein YP_002342053.1 548781 R 122587 CDS YP_002342054.1 218767542 906571 549982..550938 1 NC_003116.1 NMA0578, araC-family transcriptional regulator, len: 318 aa; shows similarity to known transcriptional regulators only at the C-terminus, in the helix-turn-helix region e.g. TR:O52834 (EMBL:AJ000061), alcR, Bordetella bronchiseptica regulator of alcaligin siderophore synthesis (303 aa), fasta scores; E(): 5.2e-06, 32.9% identity in 140 aa overlap. Contains a probable helix-turn-helix motif at aa 236-257 (Score 2068,+6.23 SD). Contains Pfam match to entry PF00165 HTH_2,Bacterial regulatory helix-turn-helix proteins, araC family; araC-family transcriptional regulator 550938 906571 NMA0578 Neisseria meningitidis Z2491 araC-family transcriptional regulator YP_002342054.1 549982 D 122587 CDS YP_002342055.1 218767543 906572 complement(551052..553067) 1 NC_003116.1 NMA0579, prolyl endopeptidase, len: 671 aa; shows weak similarity to known prolyl endopeptidases e.g. SW:PPCE_AERHY (EMBL:D14005) Aeromonas hydrophila prolyl endopeptidase (EC 3.4.21.26) (689 aa), fasta scores; E(): 3.5e-31, 25.5% identity in 666 aa overlap and SW:PPCF_FLAME (EMBL:M81461) Flavobacterium meningosepticum prolyl endopeptidase precursor (EC 3.4.21.26) (705 aa),fasta scores; E(): 1.8e-28, 24.7% identity in 684 aa overlap. Contains Pfam match to entry PF00326 Peptidase_S9, Prolyl oligopeptidase family; prolyl endopeptidase 553067 906572 NMA0579 Neisseria meningitidis Z2491 prolyl endopeptidase YP_002342055.1 551052 R 122587 CDS YP_002342056.1 218767544 906573 complement(553268..554578) 1 NC_003116.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 554578 argA 906573 argA Neisseria meningitidis Z2491 N-acetylglutamate synthase YP_002342056.1 553268 R 122587 CDS YP_002342057.1 218767545 906574 complement(554575..555009) 1 NC_003116.1 NMA0581, len: 144 aa; unknown; hypothetical protein 555009 906574 NMA0581 Neisseria meningitidis Z2491 hypothetical protein YP_002342057.1 554575 R 122587 CDS YP_002342058.1 218767546 906575 complement(555083..555724) 1 NC_003116.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 555724 pyrE 906575 pyrE Neisseria meningitidis Z2491 orotate phosphoribosyltransferase YP_002342058.1 555083 R 122587 CDS YP_002342059.1 218767547 906576 complement(555786..556523) 1 NC_003116.1 NMA0583, len: 245 aa; unknown; hypothetical protein 556523 906576 NMA0583 Neisseria meningitidis Z2491 hypothetical protein YP_002342059.1 555786 R 122587 CDS YP_002342060.1 218767548 906577 complement(556517..556957) 1 NC_003116.1 NMA0584, acetyltransferase, len: 146 aa; shows weak similarity to SW:RIMI_ECOLI (EMBL:X06117),rimI, Escherichia coli ribosomal-protein-alanine acetyltransferase (148 aa), fasta scores; E(): 1.4e-11,40.8% identity in 120 aa overlap. Also similar to hypothetical acetyltransferases. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; acetyltransferase 556957 906577 NMA0584 Neisseria meningitidis Z2491 acetyltransferase YP_002342060.1 556517 R 122587 CDS YP_002342061.1 218767549 906578 complement(556954..557631) 1 NC_003116.1 NMA0585, len: 225 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YEAZ_ECOLI (EMBL:AE000275),yeaZ, Escherichia coli hypothetical protein (231 aa),fasta scores; E(): 6.7e-13, 35.2% identity in 227 aa overlap; hypothetical protein 557631 906578 NMA0585 Neisseria meningitidis Z2491 hypothetical protein YP_002342061.1 556954 R 122587 CDS YP_002342062.1 218767550 906579 complement(557771..558613) 1 NC_003116.1 NMA0586, lipoprotein, len: 280 aa; unknown, contains a N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 558613 906579 NMA0586 Neisseria meningitidis Z2491 lipoprotein YP_002342062.1 557771 R 122587 CDS YP_002342063.1 218767551 906580 complement(558939..560003) 1 NC_003116.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 560003 fba 906580 fba Neisseria meningitidis Z2491 fructose-1,6-bisphosphate aldolase YP_002342063.1 558939 R 122587 CDS YP_002342064.1 218767552 906581 560197..561114 1 NC_003116.1 NMA0588, xerC, probable integrase/recombinase, len: 305 aa; similar to many e.g. SW:XERC_ECOLI (EMBL:M87049),xerC, Escherichia coli integrase/recombinase (298 aa),fasta scores; E(): 0, 43.7% identity in 300 aa overlap. Similar to NMA0964, fasta scores; E(): 4.4e-28, 35.0% identity in 294 aa overlap. Contains Pfam match to entry PF00589 Phage_integrase, 'Phage' integrase family; integrase/recombinase 561114 906581 NMA0588 Neisseria meningitidis Z2491 integrase/recombinase YP_002342064.1 560197 D 122587 CDS YP_002342065.1 218767553 906582 561199..563112 1 NC_003116.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 563112 dxs 906582 dxs Neisseria meningitidis Z2491 1-deoxy-D-xylulose-5-phosphate synthase YP_002342065.1 561199 D 122587 CDS YP_002342066.1 218767554 906583 complement(563197..564525) 1 NC_003116.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 564525 906583 NMA0590 Neisseria meningitidis Z2491 (dimethylallyl)adenosine tRNA methylthiotransferase YP_002342066.1 563197 R 122587 CDS YP_002342067.1 218767555 906585 565358..566641 1 NC_003116.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 566641 hemL 906585 hemL Neisseria meningitidis Z2491 glutamate-1-semialdehyde aminotransferase YP_002342067.1 565358 D 122587 CDS YP_002342068.1 218767556 906586 complement(567140..567703) 1 NC_003116.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 567703 orn 906586 orn Neisseria meningitidis Z2491 oligoribonuclease YP_002342068.1 567140 R 122587 CDS YP_002342069.1 218767557 906587 complement(567721..568608) 1 NC_003116.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 568608 prmA 906587 prmA Neisseria meningitidis Z2491 50S ribosomal protein L11 methyltransferase YP_002342069.1 567721 R 122587 CDS YP_002342070.1 218767558 906588 complement(568869..570230) 1 NC_003116.1 NMA0596, accC, probable acetyl-CoA carboxylase biotin carboxylase component, len: 453 aa; similar to many e.g. SW:ACCC_PSEAE (EMBL:L14612), accC, Pseudomonas aeruginosa biotin carboxylase (EC 6.3.4.14) (449 aa),fasta scores; E(): 0, 68.2% identity in 444 aa overlap. Contains Pfam match to entry PF00289 CPSase_L_chain,Carbamoyl-phosphate synthase (CPSase), PS00866 Carbamoyl-phosphate synthase subdomain signature 1 and PS00867 Carbamoyl-phosphate synthase subdomain signature 2; acetyl-CoA carboxylase biotin carboxylase component 570230 906588 NMA0596 Neisseria meningitidis Z2491 acetyl-CoA carboxylase biotin carboxylase component YP_002342070.1 568869 R 122587 CDS YP_002342071.1 218767559 906590 complement(570343..570798) 1 NC_003116.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 570798 accB 906590 accB Neisseria meningitidis Z2491 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002342071.1 570343 R 122587 CDS YP_002342072.1 218767560 906592 571154..572194 1 NC_003116.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 572194 queA 906592 queA Neisseria meningitidis Z2491 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_002342072.1 571154 D 122587 CDS YP_002342073.1 218767561 906593 complement(572565..573143) 1 NC_003116.1 NMA0600, len: 192 aa; unknown, similar to SW:MDAB_ECOLI (EMBL:U18656), mdaB, Escherichia coli modulator of drug activity B ( modulator of topoisomerase IV activity imparting DMP 840, adriamycin and etoposide resistance on overexpression) (193 aa),fasta scores; E(): 0, 59.2% identity in 191 aa overlap. Also similar to hypothetical proteins from bacteria and Schizosaccharomyces pombe e.g. SW:YA05_SCHPO (EMBL:Z49811), SPAC5H10.05C, Schizosaccharomyces pombe hypothetical protein (196 aa), E(): 0, 55.7% identity in 192 aa overlap. Identical, except at the N-terminus, to NMA1174, fasta scores; E(): 0, 99.3% identity in 147 aa overlap; hypothetical protein 573143 906593 NMA0600 Neisseria meningitidis Z2491 hypothetical protein YP_002342073.1 572565 R 122587 CDS YP_002342074.1 218767562 906594 573382..574281 1 NC_003116.1 NMA0601, probable lysR-family transcriptional regulator, len: 299 aa; similar to many e.g. TR:P72131 (EMBL:U35068), ptxR, Pseudomonas aeruginosa positive regulator of exotoxin A production (312 aa), fasta scores; E(): 7.4e-24, 31.9% identity in 295 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and PS00044 Bacterial regulatory proteins, lysR family signature. Contains probable helix-turn-helix motif at aa 19-40 (Score 1196, +3.26 SD); lysR-family transcriptional regulator 574281 906594 NMA0601 Neisseria meningitidis Z2491 lysR-family transcriptional regulator YP_002342074.1 573382 D 122587 CDS YP_002342075.1 218767563 906596 complement(574508..577723) 1 NC_003116.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 577723 carB 906596 carB Neisseria meningitidis Z2491 carbamoyl phosphate synthase large subunit YP_002342075.1 574508 R 122587 CDS YP_002342076.1 218767564 906597 complement(577730..578278) 1 NC_003116.1 NMA0603, len: 182 aa; unknown, lies within a region of unusually low GC content. Shows weak similarity to NMA2217, fasta scores; E(): 4.4e-05, 23.8% identity in 185 aa overlap; hypothetical protein 578278 906597 NMA0603 Neisseria meningitidis Z2491 hypothetical protein YP_002342076.1 577730 R 122587 CDS YP_002342077.1 218767565 906598 complement(578281..578844) 1 NC_003116.1 NMA0604, len: 187 aa; unknown, shows very weak similarity to the C-termini of SW:CMF3_BACSU (EMBL:Z18629), comFC, Bacillus subtilis competence protein (229 aa), fasta scores; E(): 0.077, 25.3% identity in 150 aa overlap and TR:AAD36651 (EMBL:AE001803), TM1584,Thermotoga maritima competence protein (202 aa),fasta scores; E(): 0.003, 26.1% identity in 142 aa overlap. Lies within a region of unusually low GC content; hypothetical protein 578844 906598 NMA0604 Neisseria meningitidis Z2491 hypothetical protein YP_002342077.1 578281 R 122587 CDS YP_002342078.1 218767566 906599 complement(579695..580084) 1 NC_003116.1 NMA0605, len: 129 aa; unknown, similar to ORFs present between the carA and carB genes of other Neisseria spp. e.g. TR:Q9ZIE8 (EMBL:AF029362) Neisseria gonorrhoeae ORF (129 aa), fasta scores; E(): 0, 91.5% identity in 129 aa overlap and to CDS from other bacteria e.g. SW:YCJD_ECOLI (EMBL:AE000227), ycjD, Escherichia coli hop (117 aa), fasta scores; E(): 1.7e-20, 46.0% identity in 113 aa overlap; hypothetical protein 580084 906599 NMA0605 Neisseria meningitidis Z2491 hypothetical protein YP_002342078.1 579695 R 122587 CDS YP_002342079.1 218767567 906600 complement(580081..580260) 1 NC_003116.1 NMA0606, len: 59 aa; unknown; hypothetical protein 580260 906600 NMA0606 Neisseria meningitidis Z2491 hypothetical protein YP_002342079.1 580081 R 122587 CDS YP_002342080.1 218767568 906602 complement(580363..580500) 1 NC_003116.1 NMA0607, len: 45 aa; unknown, highly similar to part of TR:Q50992 (EMBL:L36381), sucA, Neisseria gonorrhoeae 2-oxoglutarate dehydrogenase E1 component (partial CDS) (582 aa), fasta scores; E(): 8.4e-17, 93.0% identity in 43 aa overlap. Up to codon 87 in TR:Q50992 the sequence is markedly different from other sucA homologues, including sucA from this strain; hypothetical protein 580500 906602 NMA0607 Neisseria meningitidis Z2491 hypothetical protein YP_002342080.1 580363 R 122587 CDS YP_002342081.1 218767569 906603 complement(580546..581679) 1 NC_003116.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 581679 carA 906603 carA Neisseria meningitidis Z2491 carbamoyl phosphate synthase small subunit YP_002342081.1 580546 R 122587 CDS YP_002342082.1 218767570 906604 complement(583916..587029) 1 NC_003116.1 NMA0609, pilC1, pilus-associated protein, len: 1037; highly similar to many other pilus-associated proteins from Neisseris spp. e.g. TR:O05924 (EMBL:Y13020),pilC1 from Neisseria meningitidis FAM20 (1038 aa), fasta scores; E(): 0, 78.0% identity in 1043 aa overlap. Contains 2 PS00017 ATP/GTP-binding site motif A (P-loop); pilus-associated protein 587029 906604 NMA0609 Neisseria meningitidis Z2491 pilus-associated protein YP_002342082.1 583916 R 122587 CDS YP_002342083.1 218767571 906606 complement(587959..589038) 1 NC_003116.1 NMA0611, len: 375 aa; unknown, similar to many hypothetical proteins from both bacteria and eukaryotes e.g. SW:MRP_ECOLI (EMBL:U00007), mrp, Escherichia coli hypothetical protein (379 aa), fasta scores; E(): 0, 45.2% identity in 372 aa overlap. Contains a region similar to NMA0076, fasta scores; E(): 1.2e-06, 24.1% identity in 266 aa overlap and NMA0100, fasta scores; E(): 2.4e-05, 26.3% identity in 262 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 589038 906606 NMA0611 Neisseria meningitidis Z2491 hypothetical protein YP_002342083.1 587959 R 122587 CDS YP_002342084.1 218767572 906607 589403..589912 1 NC_003116.1 NMA0612, periplasmic thioredoxin, len: 169 aa; similar to many e.g. shows weak similarity to SW:CCMG_PARDE (EMBL:Z71971), ccmG, Paracoccus denitrificans periplasmic protein-disulfide oxidoreductase (179 aa), fasta scores; E(): 7e-05, 26.5% identity in 136 aa overlap and similar to SW:THIX_HAEIN (EMBL:U32791),HI1115, Haemophilus influenzae thioredoxin-like protein (167 aa), fasta scores; E(): 7.6e-26, 42.4% identity in 170 aa overlap. Contains a probable N-terminal signal sequence; periplasmic thioredoxin 589912 906607 NMA0612 Neisseria meningitidis Z2491 periplasmic thioredoxin YP_002342084.1 589403 D 122587 CDS YP_002342085.1 218767573 906608 590256..590696 1 NC_003116.1 NMA0613, probable marR-family transcriptional regulator, len: 146 aa; shows weak similarity to TR:P94314 (EMBL:U64802), cinR, Butyrivibrio fibrisolvens transcriptional repressor of cinnamoyl ester hydrolase (142 aa), fasta scores; E(): 0.0013, 30.3% identity in 145 aa overlap and SW:HPCR_ECOLI (EMBL:S56952), hpaR,Escherichia coli homoprotocatechuate degradative operon repressor (148 aa), fasta scores; E(): 8.3e-26, 55.7% identity in 131 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family and PS01117 Bacterial regulatory proteins, marR family signature; marR-family transcriptional regulator 590696 906608 NMA0613 Neisseria meningitidis Z2491 marR-family transcriptional regulator YP_002342085.1 590256 D 122587 CDS YP_002342086.1 218767574 906609 590811..591311 1 NC_003116.1 NMA0614, probable NADH:FMN oxidoreductase, len: 166 aa; similar to many NADH:FMN redox coupling protein components from multi-component monooxygenases e.g. TR:Q57501 (EMBL:Z37980), hpaC, Escherichia coli 4-hydroxyphenylacetate 3-monooxygenase coupling protein (170 aa), fasta scores; E(): 5.7e-24, 43.8% identity in 153 aa overlap and TR:O87008 (EMBL:U83405), tftC,Burkholderia cepacia chlorophenol-4-monooxygenase component 1 (179 aa), fasta scores; E(): 3.1e-15, 35.0% identity in 163 aa overlap; NADH:FMN oxidoreductase 591311 906609 NMA0614 Neisseria meningitidis Z2491 NADH:FMN oxidoreductase YP_002342086.1 590811 D 122587 CDS YP_002342087.1 218767575 906610 591329..592024 1 NC_003116.1 NMA0615, sugar-phosphate nucleotidyl transferase, len: 231 aa; Similar to the N-terminal regions of many e.g. TR:O08245 (EMBL:Y10907), mtmD,Streptomyces argillaceus TDP-D-glucose synthase (355 aa),fasta scores; E(): 4.2e-11, 30.7% identity in 241 aa overlap and SW:RFBA_XANCA (EMBL:L2394), rfbA, Xanthomonas campestris glucose-1-phosphate thymidylyltransferase involved in lipopolysaccharide biosynthesis (295 aa),fasta scores; E(): 9.1e-10, 31.7% identity in 240 aa overlap. Of a similar length to TR:AAD22456 (EMBL:AF116284) Pseudomonas aeruginosa hypothetical protein located downstream of a virulence factor (224 aa), fasta scores; E(): 0, 54.0% identity in 226 aa overlap. Similar to NMA0205, fasta scores; E(): 7.2e-09,27.9% identity in 247 aa overlap and NMA0188, fasta scores; E(): 7.2e-09, 27.9% identity in 247 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase,Nucleotidyl transferase; sugar-phosphate nucleotidyl transferase 592024 906610 NMA0615 Neisseria meningitidis Z2491 sugar-phosphate nucleotidyl transferase YP_002342087.1 591329 D 122587 CDS YP_002342088.1 218767576 906611 complement(592270..592701) 1 NC_003116.1 NMA0616, probable integral membrane protein, len: 143 aa; similar to bacterial hypothetical proteins e.g. SW:YCB6_PSEDE (EMBL:M62866) Pseudomonas denitrificans hypothetical protein (141 aa), fasta scores; E(): 1.4e-30,55.4% identity in 139 aa overlap. Contains Pfam match to entry PF00892 DUF6, Integral membrane protein. Contains hydrophobic, probable membrane-spanning regions; integral membrane protein 592701 906611 NMA0616 Neisseria meningitidis Z2491 integral membrane protein YP_002342088.1 592270 R 122587 CDS YP_002342089.1 218767577 906612 592876..594552 1 NC_003116.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 594552 fhs 906612 fhs Neisseria meningitidis Z2491 formate--tetrahydrofolate ligase YP_002342089.1 592876 D 122587 CDS YP_002342090.1 218767578 906614 594667..595758 1 NC_003116.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 595758 906614 NMA0618 Neisseria meningitidis Z2491 GTP-dependent nucleic acid-binding protein EngD YP_002342090.1 594667 D 122587 CDS YP_002342091.1 218767579 906615 596020..597888 1 NC_003116.1 NMA0619, lipopolysaccharide modification acyltransferase, len: 622 aa; similar to TR:P74874 (EMBL:U65941), oafA, Salmonella typhimurium integral membrane protein responsible for acetylation of the O-antigen (609 aa), fasta scores; E(): 0, 28.0% identity in 624 aa overlap and to TR:P72134 (EMBL:U50396), wbpC,Pseudomonas aeruginosa CDS involved in O-antigen (629 aa),fasta scores; E(): 0, 33.8% identity in 619 aa overlap. Also similar to several CDS from Caenorhabditis elegans e.g. TR:O02306 (EMBL:Z81147), T09E11.4, Caenorhabditis elegans hypothetical protein (650 aa), fasta scores; E(): 1.3e-24, 29.9% identity in 344 aa overlap. Contains hydrophobic, probable membrane-spanning regions; lipopolysaccharide modification acyltransferase 597888 906615 NMA0619 Neisseria meningitidis Z2491 lipopolysaccharide modification acyltransferase YP_002342091.1 596020 D 122587 CDS YP_002342092.1 218767580 906616 597950..599245 1 NC_003116.1 NMA0620, tyrS, probable tyrosyl-tRNA synthetase,len: 431 aa; similar to many e.g. SW:SYY_ECOLI (EMBL:J01719), tyrS, Escherichia coli tyrosyl-tRNA synthetase (EC 6.1.1.1) (423 aa), fasta scores; E(): 0,63.1% identity in 431 aa overlap. Contains Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y) and PS00178 Aminoacyl-transfer RNA synthetases class-I signature; tyrosyl-tRNA synthetase 599245 906616 NMA0620 Neisseria meningitidis Z2491 tyrosyl-tRNA synthetase YP_002342092.1 597950 D 122587 CDS YP_002342093.1 218767581 906617 599508..600464 1 NC_003116.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 600464 ribF 906617 ribF Neisseria meningitidis Z2491 bifunctional riboflavin kinase/FMN adenylyltransferase YP_002342093.1 599508 D 122587 CDS YP_002342094.1 218767582 906618 600606..603395 1 NC_003116.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 603395 ileS 906618 ileS Neisseria meningitidis Z2491 isoleucyl-tRNA synthetase YP_002342094.1 600606 D 122587 CDS YP_002342095.1 218767583 906619 604582..605079 1 NC_003116.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 605079 lspA 906619 lspA Neisseria meningitidis Z2491 lipoprotein signal peptidase YP_002342095.1 604582 D 122587 CDS YP_002342096.1 218767584 906620 605108..606076 1 NC_003116.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 606076 ispH 906620 ispH Neisseria meningitidis Z2491 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_002342096.1 605108 D 122587 CDS YP_002342097.1 218767585 906621 complement(606164..606643) 1 NC_003116.1 NMA0625, phosphatase, len: 159 aa; shows weak similarity to phosphoglycolate phosphatases e.g. SW:GPHC_ALCEU (EMBL:M68904), cbbzC, Alcaligenes eutrophus chromosomal phosphoglycolate phosphatase (231 aa), fasta scores; E(): 6.5e-08, 30.2% identity in 172 aa overlap and SW:GPH_ECOLI (EMBL:Z19601), gph, Escherichia coli phosphoglycolate phosphatase (252 aa), fasta scores; E(): 4.2e-05, 23.1% identity in 173 aa overlap. The N-terminus may have been removed by insertion of the neighbouring IS element as this CDS appears to be shorter; phosphatase 606643 906621 NMA0625 Neisseria meningitidis Z2491 phosphatase YP_002342097.1 606164 R 122587 CDS YP_002342098.1 218767586 906624 complement(609568..609894) 1 NC_003116.1 NMA0629, len: 108 aa; unknown; hypothetical protein 609894 906624 NMA0629 Neisseria meningitidis Z2491 hypothetical protein YP_002342098.1 609568 R 122587 CDS YP_002342099.1 218767587 906625 complement(609887..610801) 1 NC_003116.1 NMA0630, len: 304 aa; unknown, shows weak similarity to TR:BAA80229 (EMBL:AP000061), APE1240,Aeropyrum pernix hypothetical protein (340 aa), fasta scores; E(): 0.00016, 27.1% identity in 266 aa overlap; hypothetical protein 610801 906625 NMA0630 Neisseria meningitidis Z2491 hypothetical protein YP_002342099.1 609887 R 122587 CDS YP_002342100.1 218767588 906626 complement(610868..614116) 1 NC_003116.1 NMA0631, len: 1082 aa; unknown; hypothetical protein 614116 906626 NMA0631 Neisseria meningitidis Z2491 hypothetical protein YP_002342100.1 610868 R 122587 CDS YP_002342101.1 218767589 906627 complement(614394..617828) 1 NC_003116.1 NMA0632, dnaE, probable DNA polymerase III, alpha subunit, len: 1144 aa; similar to many e.g. SW:DP3A_VIBCH (EMBL:U30472), dnaE, Vibrio cholerae DNA polymerase III,alpha subunit (EC 2.7.7.7) (1159 aa), fasta scores; E(): 0, 46.2% identity in 1170 aa overlap; DNA polymerase III subunit alpha 617828 906627 NMA0632 Neisseria meningitidis Z2491 DNA polymerase III subunit alpha YP_002342101.1 614394 R 122587 CDS YP_002342102.1 218767590 906629 618360..618593 1 NC_003116.1 NMA0633, len: 77 aa; unknown, similar to SW:YBCJ_ECOLI (EMBL:D10588), ybcJ, Escherichia coli hypothetical protein (70 aa), fasta scores; E(): 7.7e-07,47.8% identity in 67 aa overlap and to the N-terminal half of TR:Q48692 (EMBL:X89367) Lactococcus lactis hypothetical protein (120 aa), fasta scores; E(): 5.4e-05, 43.9% identity in 66 aa overlap; hypothetical protein 618593 906629 NMA0633 Neisseria meningitidis Z2491 hypothetical protein YP_002342102.1 618360 D 122587 CDS YP_002342103.1 218767591 906630 618565..618780 1 NC_003116.1 NMA0634, len: 71 aa; unknown; hypothetical protein 618780 906630 NMA0634 Neisseria meningitidis Z2491 hypothetical protein YP_002342103.1 618565 D 122587 CDS YP_002342104.1 218767592 906631 619076..619912 1 NC_003116.1 NMA0635, len: 278 aa; unknown, similar to hypothetical proteins e.g. SW:YCIV_HAEIN (EMBL:U32820),HI1400, Haemophilus influenzae hypothetical protein (274 aa), fasta scores; E(): 0, 45.8% identity in 275 aa overlap and TR:Q9ZQI9 (EMBL:AC006218), F17L24.11,Arabidopsis thaliana hypothetical protein (312 aa), fasta scores; E(): 4.5e-20, 33.0% identity in 227 aa overlap; hypothetical protein 619912 906631 NMA0635 Neisseria meningitidis Z2491 hypothetical protein YP_002342104.1 619076 D 122587 CDS YP_002342105.1 218767593 906632 complement(619964..621256) 1 NC_003116.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 621256 avtA 906632 avtA Neisseria meningitidis Z2491 valine--pyruvate transaminase YP_002342105.1 619964 R 122587 CDS YP_002342106.1 218767594 906633 complement(621312..623222) 1 NC_003116.1 NMA0637, pglD, pilin glycosylation protein, len: 636 aa; highly similar to TR:AAC25981 (EMBL:AF014804) pglD from Neisseria meningitidis MC58 (636 aa), fasta scores; E(): 0, 96.7% identity in 636 aa overlap. Similar to many genes implicated in lipopolysaccharide biosynthesis e.g. TR:O05349 (EMBL:Y07788), rfbU, Vibrio cholerae mannosyl-transferase essential for O-antigen biosynthesis (621 aa), fasta scores; E(): 0, 47.7% identity in 616 aa overlap; pilin glycosylation protein 623222 906633 NMA0637 Neisseria meningitidis Z2491 pilin glycosylation protein YP_002342106.1 621312 R 122587 CDS YP_002342107.1 218767595 906634 complement(623270..624445) 1 NC_003116.1 NMA0638, pglC, pilin glycosylation protein, len: 404 aa; highly similar to TR:AAC25980 (EMBL:AF014804) pglC from Neisseria meningitidis MC58 (391 aa), fasta scores; E(): 0, 95.1% identity in 391 aa overlap. Contains Pfam match to entry PF01041 DegT_DnrJ_EryC1,DegT/DnrJ/EryC1/StrS family; pilin glycosylation protein 624445 906634 NMA0638 Neisseria meningitidis Z2491 pilin glycosylation protein YP_002342107.1 623270 R 122587 CDS YP_002342108.1 218767596 906635 complement(624523..625764) 1 NC_003116.1 NMA0639, pglB, pilin glycosylation protein, len: 413 aa; highly similar to TR:AAC25979 (EMBL:AF014804) pglB from Neisseria meningitidis MC58 (413 aa), fasta scores; E(): 0, 94.6% identity in 410 aa overlap. Possibly a transferase; N-terminal half is similar to the C-terminal half of e.g. SW:RFBP_SALTY (EMBL:X56793), rfbP, Salmonella typhimurium UDP-phosphate galactosephosphotransferase (476 aa), blastp scores; Expect = 1.5e-24. Contains an hydrophobic, membrane-spanning region near the N-terminus. Contains Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats); pilin glycosylation protein 625764 906635 NMA0639 Neisseria meningitidis Z2491 pilin glycosylation protein YP_002342108.1 624523 R 122587 CDS YP_002342109.1 218767597 906636 complement(625757..626920) 1 NC_003116.1 NMA0640, len: 387 aa; unknown, shows very weak similarity to galactosyl transferases e.g. SW:RFAB_SALTY (EMBL:AF026386), rfaB, Salmonella typhimurium lipopolysaccharide 1,6-galactosyltransferase (359 aa),fasta scores; E(): 0.053, 25.3% identity in 324 aa overlap; hypothetical protein 626920 906636 NMA0640 Neisseria meningitidis Z2491 hypothetical protein YP_002342109.1 625757 R 122587 CDS YP_002342110.1 218767598 906637 complement(join(626940..627518,627521..628021)) 1 NC_003116.1 NMA0641, glycosyl transferase, pseudogene,len: 1079 bp; shows weak similarity to the C-terminal half of many e.g. SW:CAPM_STAAU (EMBL:U10927), capM,Staphylococcus aureus type 1 capsular polysaccharide biosynthesis protein (380 aa), fasta scores; E(): 6.4e-09,26.8% identity in 190 aa overlap and TR:O84910 (EMBL:AF010183), wbpZ, Pseudomonas aeruginosa glycosyltransferase involved in A-band polysaccharide biosynthesis (381 aa), fasta scores; E(): 9e-07, 25.7% identity in 191 aa overlap. Also similar to NMA1057, fasta scores; E(): 1.3e-06, 28.7% identity in 129 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1,Glycosyl transferases group 1. Contains a g{16} repeat which would allow this to be translated as an intact CDS,if variable; hypothetical protein 628021 906637 NMA0641 Neisseria meningitidis Z2491 hypothetical protein YP_002342110.1 626940 R 122587 CDS YP_002342111.1 218767599 906638 complement(628018..629439) 1 NC_003116.1 NMA0643, lipopolysaccharide biosynthesis translocase, len: 473 aa; shows weak similarity to several proteins implicated in lipopolysaccharide biosynthesis e.g. TR:Q56050 (EMBL:U40830), epsM, Streptococcus thermophilus eps cluster gene (473 aa), fasta scores; E(): 3.8e-10, 20.4% identity in 471 aa overlap and TR:Q56865 (EMBL:U46859), wzx, Yersinia enterocolitica O-antigen 'flippase' (429 aa), fasta scores; E(): 3.2e-05,21.7% identity in 392 aa overlap. Contains hydrophobic,probable membrane-spanning regions; lipopolysaccharide biosynthesis translocase 629439 906638 NMA0643 Neisseria meningitidis Z2491 lipopolysaccharide biosynthesis translocase YP_002342111.1 628018 R 122587 CDS YP_002342112.1 218767600 906639 complement(629634..630743) 1 NC_003116.1 NMA0644, ribD, probable diaminohydroxyphosphoribosylaminopyrimidine deaminase/phosphoribosylamino)uracil reductase, len: 369 aa; similar to many e.g. SW:RIBD_ACTPL (EMBL:U27202),ribD, Actinobacillus pleuropneumoniae diaminohydroxyphosphoribosylaminopyrimidine deaminase/phosphoribosylamino)uracil reductase (EC 3.5.4.26) (EC 1.1.1.193) (410 aa), fasta scores; E(): 0,42.4% identity in 323 aa overlap. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature and PS00017 ATP/GTP-binding site motif A (P-loop); diaminohydroxyphosphoribosylaminopyrimidine deaminase/phosphoribosylamino)uracil reductase 630743 906639 NMA0644 Neisseria meningitidis Z2491 diaminohydroxyphosphoribosylaminopyrimidine deaminase/phosphoribosylamino)uracil reductase YP_002342112.1 629634 R 122587 CDS YP_002342113.1 218767601 906640 complement(630775..631239) 1 NC_003116.1 NMA0645, len: 154 aa; unknown, similar to many bacterial hypothetical proteins e.g. TR:O50470 (EMBL:AJ002783) Neisseria gonorrhoeae hypothetical protein (partial CDS) (109 aa), fasta scores; E(): 0, 93.5% identity in 108 aa overlap; transcriptional regulator NrdR 631239 nrdR 906640 nrdR Neisseria meningitidis Z2491 transcriptional regulator NrdR YP_002342113.1 630775 R 122587 CDS YP_002342114.1 218767602 906641 complement(631269..632111) 1 NC_003116.1 NMA0646, len: 280 aa; unknown, highly similar to TR:O50469 (EMBL:AJ002783), yafJ, Neisseria gonorrhoeae hypothetical protein (280 aa), fasta scores; E(): 0, 93.6% identity in 281 aa overlap and similar to SW:YAFJ_ECOLI (EMBL:D38582), yafJ, Escherichia coli hypothetical protein (255 aa), fasta scores; E(): 0, 51.8% identity in 255 aa overlap and to other bacterial hypothetical proteins; hypothetical protein 632111 906641 NMA0646 Neisseria meningitidis Z2491 hypothetical protein YP_002342114.1 631269 R 122587 CDS YP_002342115.1 218767603 906642 complement(632755..633834) 1 NC_003116.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 633834 aroB 906642 aroB Neisseria meningitidis Z2491 3-dehydroquinate synthase YP_002342115.1 632755 R 122587 CDS YP_002342116.1 218767604 906643 complement(633914..634426) 1 NC_003116.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 634426 aroK 906643 aroK Neisseria meningitidis Z2491 shikimate kinase YP_002342116.1 633914 R 122587 CDS YP_002342117.1 218767605 906644 complement(635588..637873) 1 NC_003116.1 NMA0650, pilQ, pilus secretin, len: 761 aa; highly similar to secretins from Neisseria spp. e.g. TR:Q9ZHF3 (EMBL:AF066056), pilQ, Neisseria meningitidis strain H44/76 (serogroup B) secretin precursor (766 aa), fasta scores; E(): 0, 84.9% identity in 766 aa overlap. Contains 5 copies of the small basic repeat PAKQQAAA (with slight degeneracy). Contains Pfam match to entry PF00263 Bac_GSPproteins, Bacterial type II secretion system protein and PS00875 Bacterial type II secretion system protein D signature. Contains a probable N-terminal signal sequence; pilus secretin 637873 906644 NMA0650 Neisseria meningitidis Z2491 pilus secretin YP_002342117.1 635588 R 122587 CDS YP_002342118.1 218767606 906645 complement(637892..638437) 1 NC_003116.1 NMA0651, pilP, pilus assembly protein, len: 181 aa; highly similar to TR:Q50971 (EMBL:U40596), pilP, Neisseria gonorrhoeae type IV pilus biogenesis protein (180 aa),fasta scores; E(): 0, 96.7% identity in 181 aa overlap. Contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; pilus assembly protein 638437 906645 NMA0651 Neisseria meningitidis Z2491 pilus assembly protein YP_002342118.1 637892 R 122587 CDS YP_002342119.1 218767607 906646 complement(638455..639102) 1 NC_003116.1 NMA0652, pilO, pilus assembly protein, len: 215 aa; highly similar to TR:Q50970 (EMBL:U40596), pilO, Neisseria gonorrhoeae type IV pilus biogenesis protein (215 aa),fasta scores; E(): 0, 98.6% identity in 215 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains an hydrophobic, membrane-spanning region; pilus assembly protein 639102 906646 NMA0652 Neisseria meningitidis Z2491 pilus assembly protein YP_002342119.1 638455 R 122587 CDS YP_002342120.1 218767608 906647 complement(639103..639702) 1 NC_003116.1 NMA0653, pilN, probable pilus assembly protein,len: 199 aa; similar to TR:Q52540 (EMBL:L28837), pilN,Pseudomonas syringae gene required for pilus expression (199 aa), fasta scores; E(): 1.5e-13, 27.9% identity in 197 aa overlap and highly similar to TR:O05129 (EMBL:U72876), pilN, Neisseria gonorrhoeae FA19 pilN (203 aa), fasta scores; E(): 0, 81.0% identity in 179 aa overlap (divergent at the C-terminus). Contains an hydrophobic, membrane-spanning region; pilus assembly protein 639702 906647 NMA0653 Neisseria meningitidis Z2491 pilus assembly protein YP_002342120.1 639103 R 122587 CDS YP_002342121.1 218767609 906648 complement(639705..640820) 1 NC_003116.1 NMA0654, pilM, probable pilus assembly protein,len: 371 aa; similar to TR:Q51351 (EMBL:U12892), pilM,Pseudomonas aeruginosa type 4 fimbrial assembly protein (354 aa), fasta scores; E(): 1.5e-17, 25.6% identity in 347 aa overlap and highly similar to TR:O05130 (EMBL:U72876), pilM, Neisseria gonorrhoeae FA19 pilM (371 aa), fasta scores; E(): 0, 94.6% identity in 371 aa overlap; pilus assembly protein 640820 906648 NMA0654 Neisseria meningitidis Z2491 pilus assembly protein YP_002342121.1 639705 R 122587 CDS YP_002342122.1 218767610 906649 640972..643368 1 NC_003116.1 NMA0655, ponA, penicillin-binding protein 1, len: 798 aa; previously sequenced as TR:O05194 (EMBL:U80933) Neisseria meningitidis Z2491 penicillin-binding protein 1 (798 aa), fasta scores; E(): 0, 100.0% identity in 798 aa overlap. Contains Pfam matches to entry PF00912 Transglycosyl, Transglycosylase and to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. Contains probable N-terminal signal sequence; penicillin-binding protein 1 643368 906649 NMA0655 Neisseria meningitidis Z2491 penicillin-binding protein 1 YP_002342122.1 640972 D 122587 CDS YP_002342123.1 218767611 906650 complement(643489..644118) 1 NC_003116.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 644118 engB 906650 engB Neisseria meningitidis Z2491 ribosome biogenesis GTP-binding protein YsxC YP_002342123.1 643489 R 122587 CDS YP_002342124.1 218767612 906651 644324..644947 1 NC_003116.1 NMA0658, cyc, probable cytochrome C, len: 207 aa; similar to many e.g. SW:CYC4_PSEST (EMBL:U05988), cc4,Pseudomonas stutzeri cytochrome C4 precursor (210 aa),fasta scores; E(): 1e-19, 34.9% identity in 212 aa overlap. Contains two Pfam matches to entry PF00034 cytochrome_c, Cytochrome c and two PS00190 Cytochrome c family heme-binding site signature. Contains a probable N-terminal signal sequence; cytochrome C 644947 906651 NMA0658 Neisseria meningitidis Z2491 cytochrome C YP_002342124.1 644324 D 122587 CDS YP_002342125.1 218767613 906652 645224..647176 1 NC_003116.1 NMA0659, membrane protein, len: 650 aa; similar to TR:Q9ZG10 (EMBL:AF089765), resB, Thiobacillus ferrooxidans cytochrome C biosynthesis protein (591 aa), fasta scores; E(): 0, 32.0% identity in 659 aa overlap. Shows weak similarity to TR:O50041 (EMBL:U71000),ccs1, Chlamydomonas reinhardtii nuclear gene required for the post-translational assembly of chloroplast cytochrome C (613 aa), fasta scores; E(): 4.2e-05, 26.2% identity in 305 aa overlap. Contains a N-terminal signal sequence and hydrophobic, membrane-spanning regions; hypothetical protein 647176 906652 NMA0659 Neisseria meningitidis Z2491 hypothetical protein YP_002342125.1 645224 D 122587 CDS YP_002342126.1 218767614 906653 647169..648356 1 NC_003116.1 NMA0660, probable membrane protein, len: 395 aa; similar to chloroplast genes required for cytochrome C biosynthesis e.g SW:CCSA_CHLRE (EMBL:U15556), ccsA,Chlamydomonas reinhardtii cytochrome C biogenesis protein (353 aa), fasta scores; E(): 1e-30, 36.1% identity in 266 aa overlap. Also similar to bacterial hypothetical proteins e.g. TR:Q9ZG09 (EMBL:AF089766), resC,Thiobacillus ferrooxidans cytochrome C-type biogenesis protein (381 aa), fasta scores; E(): 0, 45.2% identity in 378 aa overlap. Contains hydrophobic, probable membrane-spanning regions; hypothetical protein 648356 906653 NMA0660 Neisseria meningitidis Z2491 hypothetical protein YP_002342126.1 647169 D 122587 CDS YP_002342127.1 218767615 906654 648473..649537 1 NC_003116.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 649537 gcp 906654 gcp Neisseria meningitidis Z2491 DNA-binding/iron metalloprotein/AP endonuclease YP_002342127.1 648473 D 122587 CDS YP_002342128.1 218767616 906655 complement(649581..650477) 1 NC_003116.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 650477 906655 NMA0662 Neisseria meningitidis Z2491 lipid A biosynthesis lauroyl acyltransferase YP_002342128.1 649581 R 122587 CDS YP_002342129.1 218767617 906656 650823..651992 1 NC_003116.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 651992 metK 906656 metK Neisseria meningitidis Z2491 S-adenosylmethionine synthetase YP_002342129.1 650823 D 122587 CDS YP_002342130.1 218767618 906657 join(652241..652693,652692..652883) 1 NC_003116.1 transposase for IS1016 652883 906657 NMA0664 Neisseria meningitidis Z2491 transposase for IS1016 YP_002342130.1 652241 D 122587 CDS YP_002342131.1 218767619 906659 complement(652959..654368) 1 NC_003116.1 NMA0665, probable peptidase, len: 469 aa; similar to many e.g. TR:O85665 (EMBL:AF071224), pbp3, Neisseria gonorrhoeae penicillin binding protein 3 (469 aa), fasta scores; E(): 0, 96.6% identity in 469 aa overlap and SW:PBP4_ECOLI (EMBL:X59460), dacB, Escherichia coli penicillin-binding protein (477 aa), fasta scores; E(): 7.9e-21, 27.0% identity in 456 aa overlap. Contains probable N-terminal signal sequence; peptidase 654368 906659 NMA0665 Neisseria meningitidis Z2491 peptidase YP_002342131.1 652959 R 122587 CDS YP_002342132.1 218767620 906660 654533..655099 1 NC_003116.1 NMA0666, probable oxidoreductase, len: 188 aa; similar to TR:AAD37373 (EMBL:AF145234), nqr, Arabidopsis thaliana NADPH:quinone oxidoreductase 9196 aa), fasta scores; E(): 2.9e-13, 35.7% identity in 168 aa overlap and to bacterial hypothetical proteins; oxidoreductase 655099 906660 NMA0666 Neisseria meningitidis Z2491 oxidoreductase YP_002342132.1 654533 D 122587 CDS YP_002342133.1 218767621 906661 655668..656981 1 NC_003116.1 NMA0668, probable transmembrane transport protein,len: 437 aa; similar to e.g. SW:CITM_BACSU (EMBL:U62003),citM, Bacillus subtilis Mg2+/citrate complex secondary transporter (433 aa), fasta scores; E(): 0, 33.2% identity in 437 aa overlap. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein 656981 906661 NMA0668 Neisseria meningitidis Z2491 transmembrane transport protein YP_002342133.1 655668 D 122587 CDS YP_002342134.1 218767622 906663 657370..658620 1 NC_003116.1 NMA0670, two-component system sensor kinase, len: 416 aa; similar to several sensor kinases e.g. SW:IRLS_BURPS (EMBL:AF005358), irlS, Burkholderia pseudomallei sensor protein (464 aa), fasta scores; E(): 4.7e-16, 26.8% identity in 381 aa overlap. Also similar to SW:YGIY_ECOLI (EMBL:U28377), ygiY, Escherichia coli probable sensor protein (449 aa), fasta scores; E(): 8.7e-28, 31.6% identity in 335 aa overlap. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain. Contains an hydrophobic, membrane-spanning region; two-component system sensor kinase 658620 906663 NMA0670 Neisseria meningitidis Z2491 two-component system sensor kinase YP_002342134.1 657370 D 122587 CDS YP_002342135.1 218767623 906665 complement(658879..660372) 1 NC_003116.1 NMA0672, len: 497 aa; unknown, similar to the N-terminal half of SW:RNE_ECOLI (EMBL:AE000209), rne,Escherichia coli ribonuclease E (1061 aa), fasta scores; E(): 0, 35.6% identity in 464 aa overlap and to SW:CAFA_ECOLI (EMBL:X57166), cafA, Escherichia coli cytoplasmic axial filament protein (488 aa), fasta scores; E(): 0, 49.5% identity in 491 aa overlap. Also similar to many bacterial hypothetical proteins. Similar to the N-terminal half of NMA0071 (rne), fasta scores; E(): 0,33.0% identity in 482 aa overlap; hypothetical protein 660372 906665 NMA0672 Neisseria meningitidis Z2491 hypothetical protein YP_002342135.1 658879 R 122587 CDS YP_002342136.1 218767624 906666 660586..660843 1 NC_003116.1 NMA0673, glutaredoxin, len: 85 aa; similar to many e.g. SW:GLR3_ECOLI (EMBL:U00039), grxC,Escherichia coli glutaredoxin 3 (82 aa), fasta scores; E(): 5.4e-11, 47.5% identity in 80 aa overlap. Contains PS00194 Thioredoxin family active site; glutaredoxin 660843 906666 NMA0673 Neisseria meningitidis Z2491 glutaredoxin YP_002342136.1 660586 D 122587 CDS YP_002342137.1 218767625 906667 660864..661307 1 NC_003116.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 661307 secB 906667 secB Neisseria meningitidis Z2491 preprotein translocase subunit SecB YP_002342137.1 660864 D 122587 CDS YP_002342138.1 218767626 906668 661393..663435 1 NC_003116.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 663435 906668 NMA0675 Neisseria meningitidis Z2491 ATP-dependent DNA helicase RecG YP_002342138.1 661393 D 122587 CDS YP_002342139.1 218767627 906669 complement(664694..665737) 1 NC_003116.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 665737 argC 906669 argC Neisseria meningitidis Z2491 N-acetyl-gamma-glutamyl-phosphate reductase YP_002342139.1 664694 R 122587 CDS YP_002342140.1 218767628 906670 complement(665734..666027) 1 NC_003116.1 NMA0677, len: 97 aa; unknown, contains a region similar to NMA0700, fasta scores; E(): 6.1e-09, 64.4% identity in 45 aa overlap; hypothetical protein 666027 906670 NMA0677 Neisseria meningitidis Z2491 hypothetical protein YP_002342140.1 665734 R 122587 CDS YP_002342141.1 218767629 906673 667552..667779 1 NC_003116.1 NMA0680, lipoprotein, len: 75 aa; unknown,contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains one hydrophobic, membrane-spanning region. Lies within a region of unusually low GC content; lipoprotein 667779 906673 NMA0680 Neisseria meningitidis Z2491 lipoprotein YP_002342141.1 667552 D 122587 CDS YP_002342142.1 218767630 906674 667772..668125 1 NC_003116.1 NMA0681, len: 117 aa; unknown; hypothetical protein 668125 906674 NMA0681 Neisseria meningitidis Z2491 hypothetical protein YP_002342142.1 667772 D 122587 CDS YP_002342143.1 218767631 906676 670145..670447 1 NC_003116.1 NMA0684, len: 100 aa; unknown; hypothetical protein 670447 906676 NMA0684 Neisseria meningitidis Z2491 hypothetical protein YP_002342143.1 670145 D 122587 CDS YP_002342144.1 218767632 906677 670462..670632 1 NC_003116.1 NMA0685, len: 56 aa; unknown; hypothetical protein 670632 906677 NMA0685 Neisseria meningitidis Z2491 hypothetical protein YP_002342144.1 670462 D 122587 CDS YP_002342145.1 218767633 906679 671031..672773 1 NC_003116.1 NMA0687, probable periplasmic protein, len: 580 aa; similar to hemolysin activating proteins e.g. SW:HLYB_SERMA (EMBL:M22618), shlB, Serratia marcescens protein required for extracellular secretion and activation of hemoysin (557 aa), fasta scores; E(): 1.7e-07, 25.1% identity in 542 aa overlap and to SW:FHAC_BORPE (EMBL:X64876), fhaC, Bordetella pertussis hemolysin activator-like protein (584 aa), fasta scores; E(): 9.7e-08, 25.8% identity in 577 aa overlap. Contains a region identical to TR:P72090 (EMBL:U56747) Neisseria meningitidis strain Z2491 sequence found in Z2491 but not in Neisseria gonorrhoeae strain MS11, fasta scores; E(): 2.4e-23, 100.0% identity in 69 aa overlap. Contains a probable N-terminal signal sequence; hypothetical protein 672773 906679 NMA0687 Neisseria meningitidis Z2491 hypothetical protein YP_002342145.1 671031 D 122587 CDS YP_002342146.1 218767634 906680 672883..678930 1 NC_003116.1 NMA0688, len: 2015 aa; similar to the N-terminal half of SW:FHAB_BORPE (EMBL:M60351), fhaB, Bordetella pertussis filamentous haemagglutinin (3591 aa), fasta scores; E(): 8.4e-25, 22.8% identity in 1884 aa overlap and to SW:HLYA_PROMI (EMBL:M30186), hmpA, Proteus mirabilis calcium-independent hemolysin (1577 aa), fasta scores; E(): 1.9e-09, 22.9% identity in 1692 aa overlap. Contains a region identical to TR:P72087 (EMBL:U56741) Neisseria meningitidis strain Z2491 sequence found in Z2491 but not in Neisseria gonorrhoeae strain MS11, fasta scores; E(): 2.3e-32, 100.0% identity in 117 aa overlap. The C-terminal region is highly similar to NMA0690, fasta scores; E(): 0, 70.6% identity in 571 aa overlap and NMA0962, fasta scores; E(): 0, 54.0% identity in 622 aa overlap. Also contains a sequence motif ILAYSKLVAGTVSGVVGGDVNTAANAAKVAIENNLL (codon 1629 to codon 1664) which occurs (with some degeneracy) within NMA0690,NMA0692 and NMA0695; hemagglutinin 678930 906680 NMA0688 Neisseria meningitidis Z2491 hemagglutinin YP_002342146.1 672883 D 122587 CDS YP_002342147.1 218767635 906681 678935..679318 1 NC_003116.1 NMA0689, len: 127 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 679318 906681 NMA0689 Neisseria meningitidis Z2491 hypothetical protein YP_002342147.1 678935 D 122587 CDS YP_002342148.1 218767636 906682 679568..682249 1 NC_003116.1 NMA0690, len: 893 aa; unknown, highly similar to the C-terminal region of NMA0688, fasta scores; E(): 0,70.6% identity in 571 aa overlap and to NMA0992, fasta scores; E(): 0, 71.9% identity in 620 aa overlap. Also contains a sequence motif ILAYSKLVAGTVSGVVGGDVNAAANAAEVAVKNNQL (codon 540 to codon 575) which occurs (with some degeneracy) within NMA0688,NMA0692, and NMA0695. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 682249 906682 NMA0690 Neisseria meningitidis Z2491 hypothetical protein YP_002342148.1 679568 D 122587 CDS YP_002342149.1 218767637 906684 682265..682696 1 NC_003116.1 NMA0691, len: 143 aa; unknown, Asn-rich N-terminus,lies within a region of unusually low GC content; hypothetical protein 682696 906684 NMA0691 Neisseria meningitidis Z2491 hypothetical protein YP_002342149.1 682265 D 122587 CDS YP_002342150.1 218767638 906685 682841..685342 1 NC_003116.1 NMA0692, len: 692 aa; unknown, contains an Ala-rich region from aa 330-400 approx. Highly similar to NMA0690,fasta scores; E(): 0, 71.9% identity in 620 aa overlap and to the C-terminal region of NMA0688, fasta scores; E(): 0,54.0% identity in 622 aa overlap. The Ala-rich region is not well conserved in NMA0690 and NMA0688. Also contains a sequence motif IAYSQIIAGSAVALVKGDVNTAVNAATVAVENNSL (codon 586 to codon 620) which occurs (with some degeneracy) within NMA0688, NMA0690, and NMA0695. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 685342 906685 NMA0692 Neisseria meningitidis Z2491 hypothetical protein YP_002342150.1 682841 D 122587 CDS YP_002342151.1 218767639 906686 685339..685827 1 NC_003116.1 NMA0693, len: 162 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 685827 906686 NMA0693 Neisseria meningitidis Z2491 hypothetical protein YP_002342151.1 685339 D 122587 CDS YP_002342152.1 218767640 906687 686015..686287 1 NC_003116.1 NMA0694, len: 90 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 686287 906687 NMA0694 Neisseria meningitidis Z2491 hypothetical protein YP_002342152.1 686015 D 122587 CDS YP_002342153.1 218767641 906688 686491..687459 1 NC_003116.1 NMA0695, len: 322 aa; unknown, contains an sequence motif ITAYSKLVAGTASAVVGGDVNTAANAAQIAVENNTL (codon 22 to codon 57) which occurs (with some degeneracy) at different positions within NMA0688, NMA0690 and NMA0692; hypothetical protein 687459 906688 NMA0695 Neisseria meningitidis Z2491 hypothetical protein YP_002342153.1 686491 D 122587 CDS YP_002342154.1 218767642 906689 687462..688397 1 NC_003116.1 NMA0696, len: 311 aa; unknown; hypothetical protein 688397 906689 NMA0696 Neisseria meningitidis Z2491 hypothetical protein YP_002342154.1 687462 D 122587 CDS YP_002342155.1 218767643 906690 688810..689160 1 NC_003116.1 NMA0696A, len: 311 aa; unknown; hypothetical protein 689160 906690 NMA0696A Neisseria meningitidis Z2491 hypothetical protein YP_002342155.1 688810 D 122587 CDS YP_002342156.1 218767644 906691 689167..689346 1 NC_003116.1 NMA0697, len: 59 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 689346 906691 NMA0697 Neisseria meningitidis Z2491 hypothetical protein YP_002342156.1 689167 D 122587 CDS YP_002342157.1 218767645 906692 689728..690186 1 NC_003116.1 NMA0698, periplasmic protein, len: 152 aa; unknown, contains a probable N-terminal signal sequence and lies within a region of unusually low GC content; hypothetical protein 690186 906692 NMA0698 Neisseria meningitidis Z2491 hypothetical protein YP_002342157.1 689728 D 122587 CDS YP_002342158.1 218767646 906694 complement(690700..691926) 1 NC_003116.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; this protein contains a C-terminal extension of unknown function; ribonuclease BN/unknown domain fusion protein 691926 rbn 906694 rbn Neisseria meningitidis Z2491 ribonuclease BN/unknown domain fusion protein YP_002342158.1 690700 R 122587 CDS YP_002342159.1 218767647 906696 692470..693129 1 NC_003116.1 NMA0702, len: 219 aa; similar to TR:Q52925 (EMBL:Z50189), exsB, Rhizobium meliloti regulator of succinoglycan biosynthesis (not a transcriptional regulator) (234 aa), fasta scores; E(): 3.1e-15, 32.7% identity in 205 aa overlap. Also similar to many hbacterial ypothetical proteins e.g. SW:YBAX_HAEIN (EMBL:U32798), HI1191, Haemophilus influenzae hypothetical protein (196 aa), fasta scores; E(): 0, 79.2% identity in 173 aa overlap; hypothetical protein 693129 906696 NMA0702 Neisseria meningitidis Z2491 hypothetical protein YP_002342159.1 692470 D 122587 CDS YP_002342160.1 218767648 906697 693157..693675 1 NC_003116.1 NMA0703, len: 172 aa; unknown; hypothetical protein 693675 906697 NMA0703 Neisseria meningitidis Z2491 hypothetical protein YP_002342160.1 693157 D 122587 CDS YP_002342161.1 218767649 906698 693682..694104 1 NC_003116.1 NMA0704, len: 140 aa; similar to many hypothetical proteins e.g. SW:YB90_HAEIN (EMBL:U32798), HI1190,Haemophilus influenzae hypothetical protein (141 aa),fasta scores; E(): 5.1e-32, 58.0% identity in 138 aa overlap. Shows very weak similarity to eukaryotic 6-pyruvoyl-tetrahydropterin synthases e.g. SW:PTPS_RAT (EMBL:M77850), pts, Rattus norvegicus 6-pyruvoyl tetrahydrobiopterin synthase precursor (EC 4.6.1.10) (144 aa), fasta scores; E(): 0.0062, 27.3% identity in 154 aa overlap. Contains Pfam match to entry PF01242 PTPS,6-pyruvoyl tetrahydropterin synthase; hypothetical protein 694104 906698 NMA0704 Neisseria meningitidis Z2491 hypothetical protein YP_002342161.1 693682 D 122587 CDS YP_002342162.1 218767650 906699 694373..694744 1 NC_003116.1 NMA0706, membrane protein, len: 123 aa; similar to SW:YTRP_LACLA (EMBL:M87483) Lactococcus lactis (subsp. lactis) hypothetical protein (119 aa), fasta scores; E(): 9.2e-11, 39.7% identity in 116 aa overlap. Contains hydrophobic, membrane-spanning regions; hypothetical protein 694744 906699 NMA0706 Neisseria meningitidis Z2491 hypothetical protein YP_002342162.1 694373 D 122587 CDS YP_002342163.1 218767651 906700 694741..695379 1 NC_003116.1 NMA0707, len: 212 aa; similar to many bacterial hypothetical proteins e.g. SW:YGCF_HAEIN (EMBL:U32798),HI1189, Haemophilus influenzae hypothetical protein (211 aa), fasta scores; E(): 0, 61.4% identity in 202 aa overlap; hypothetical protein 695379 906700 NMA0707 Neisseria meningitidis Z2491 hypothetical protein YP_002342163.1 694741 D 122587 CDS YP_002342164.1 218767652 906701 complement(696057..697142) 1 NC_003116.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 697142 906701 NMA0708 Neisseria meningitidis Z2491 beta-hexosaminidase YP_002342164.1 696057 R 122587 CDS YP_002342165.1 218767653 906702 complement(697199..698719) 1 NC_003116.1 NMA0709, probable integral membrane protein, len: 506 aa; similar to bacterial hypothetical proteins e.g. SW:YF86_HAEIN (EMBL:U32832), HI1586, Haemophilus influenzae hypothetical protein (519 aa), fasta scores; E(): 0, 60.7% identity in 507 aa overlap. Contains hydrophobic, probable membrane-spanning regions; integral membrane protein 698719 906702 NMA0709 Neisseria meningitidis Z2491 integral membrane protein YP_002342165.1 697199 R 122587 CDS YP_002342166.1 218767654 906703 complement(698921..700420) 1 NC_003116.1 NMA0710, probable periplasmic serine protease, len: 499 aa; similar to many e.g. TR:Q57155 (EMBL:U49151),mucD, Pseudomonas aeruginosa gene from locus affecting conversion to mucoidy in cystic fibrosis (474 aa), fasta scores; E(): 0, 49.8% identity in 454 aa overlap and SW:HTRA_ECOLI (EMBL:M36536), htrA, Escherichia coli protease DO precursor (EC 3.4.21.-) (474 aa), fasta scores; E(): 0, 33.5% identity in 457 aa overlap. Contains two Pfam matches to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF), Pfam match to entry PF00089 trypsin, Trypsin and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; serine protease 700420 906703 NMA0710 Neisseria meningitidis Z2491 serine protease YP_002342166.1 698921 R 122587 CDS YP_002342167.1 218767655 906704 complement(700558..701187) 1 NC_003116.1 NMA0711, nth, probable endonuclease III, len: 209 aa; similar to many e.g. SW:END3_ECOLI (EMBL:J02857), nth,Escherichia coli endonuclease III (EC 4.2.99.18) (211 aa),fasta scores; E(): 0, 72.1% identity in 208 aa overlap. Contains Pfam match to entry PF00730 Endonuclease_3,Endonuclease III and PS01155 Endonuclease III family signature; endonuclease III 701187 906704 NMA0711 Neisseria meningitidis Z2491 endonuclease III YP_002342167.1 700558 R 122587 CDS YP_002342168.1 218767656 906705 complement(701233..701646) 1 NC_003116.1 NMA0712, membrane protein, len: 137 aa; similar to e.g. SW:YQAA_ECOLI (EMBL:AE000353), yqaA,Escherichia coli hypothetical protein (142 aa), fasta scores; E(): 1.1e-12, 34.8% identity in 141 aa overlap. Contains hydrophobic, membrane-spanning regions; hypothetical protein 701646 906705 NMA0712 Neisseria meningitidis Z2491 hypothetical protein YP_002342168.1 701233 R 122587 CDS YP_002342169.1 218767657 906706 702236..703459 1 NC_003116.1 NMA0714, probable transmembrane hexose transporter,len: 407 aa; similar to sugar transporters e.g. SW:GLUP_BRUAB (EMBL:U43785), gluP, Brucella abortus glucose/galactose transporter (412 aa), fasta scores; E(): 0, 52.9% identity in 403 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains hydrophobic, probable membrane-spanning regions; transmembrane hexose transporter 703459 906706 NMA0714 Neisseria meningitidis Z2491 transmembrane hexose transporter YP_002342169.1 702236 D 122587 CDS YP_002342170.1 218767658 906707 703750..705129 1 NC_003116.1 NMA0715, probable transmembrane transport protein,len: 459 aa; similar to SW:NHAC_BACFI (EMBL:U61539), nhaC,Bacillus firmus Na(+)/H(+) antiporter (462 aa), fasta scores; E(): 0, 36.5% identity in 446 aa overlap and to transporters. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein 705129 906707 NMA0715 Neisseria meningitidis Z2491 transmembrane transport protein YP_002342170.1 703750 D 122587 CDS YP_002342171.1 218767659 906708 complement(705258..706082) 1 NC_003116.1 NMA0716, len: 274 aa; shows weak similarity to SW:HLYC_TREHY (EMBL:X73141), tlyC, Treponema hyodysenteriae hemolysin C (268 aa), fasta scores; E(): 7.4e-23, 33.7% identity in 252 aa overlap. Also similar to many hypothetical proteins e.g. SW:YBEX_ECOLI (EMBL:AE000170), ybeX, Escherichia coli hypothetical protein (292 aa), fasta scores; E(): 0, 51.1% identity in 266 aa overlap. Shows weak similarity to the C-terminal half of NMA1694, E(): 9.5e-17, 26.4% identity in 242 aa overlap. The membrane-spanning regions of NMA1694 do not lie within this region. Contains two Pfam matches to entry PF00571 CBS, CBS domain; hypothetical protein 706082 906708 NMA0716 Neisseria meningitidis Z2491 hypothetical protein YP_002342171.1 705258 R 122587 CDS YP_002342172.1 218767660 906709 complement(706084..706599) 1 NC_003116.1 NMA0717, len: 171 aa; similar to many bacterial hypothetical proteins e.g. SW:YBEY_ECOLI (EMBL:AE000170),ybeY, Escherichia coli hypothetical protein (155 aa),fasta scores; E(): 1.9e-24, 47.5% identity in 139 aa overlap; hypothetical protein 706599 906709 NMA0717 Neisseria meningitidis Z2491 hypothetical protein YP_002342172.1 706084 R 122587 CDS YP_002342173.1 218767661 906710 706718..707653 1 NC_003116.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 707653 hemC 906710 hemC Neisseria meningitidis Z2491 porphobilinogen deaminase YP_002342173.1 706718 D 122587 CDS YP_002342174.1 218767662 906711 complement(708160..709353) 1 NC_003116.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 709353 aspC 906711 aspC Neisseria meningitidis Z2491 aromatic amino acid aminotransferase YP_002342174.1 708160 R 122587 CDS YP_002342175.1 218767663 906712 complement(709435..709932) 1 NC_003116.1 NMA0720, len: 165 aa; unknown; hypothetical protein 709932 906712 NMA0720 Neisseria meningitidis Z2491 hypothetical protein YP_002342175.1 709435 R 122587 CDS YP_002342176.1 218767664 906713 710048..710251 1 NC_003116.1 NMA0721, len: 67 aa; unknown; hypothetical protein 710251 906713 NMA0721 Neisseria meningitidis Z2491 hypothetical protein YP_002342176.1 710048 D 122587 CDS YP_002342177.1 218767665 906714 complement(710419..712005) 1 NC_003116.1 NMA0722, probable transmembrane transport protein,len: 528 aa; shows weak similarity to lactate permeases e.g. SW:LLDP_ECOLI (EMBL:L13970), lldP, Escherichia coli L-lactate permease (551 aa), fasta scores; E(): 2.4e-29,25.3% identity in 550 aa overlap. Also similar to many hypothetical lactate permeases e.g. SW:YC18_HAEIN (EMBL:U32801), HI1218, Haemophilus influenzae L-lactate permease (532 aa), fasta scores; E(): 0, 57.3% identity in 527 aa overlap. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein 712005 906714 NMA0722 Neisseria meningitidis Z2491 transmembrane transport protein YP_002342177.1 710419 R 122587 CDS YP_002342178.1 218767666 906715 complement(712274..712996) 1 NC_003116.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 712996 906715 NMA0723 Neisseria meningitidis Z2491 UDP-2,3-diacylglucosamine hydrolase YP_002342178.1 712274 R 122587 CDS YP_002342179.1 218767667 906716 713245..716730 1 NC_003116.1 NMA0724, len: 1161 aa; unknown, contains two coiled-coil domains and shows weak similarity to many bacterial hypothetical proteins (also with coiled-coil domains) e.g. TR:O59462 (EMBL:AP000007), PH1798,Pyrococcus horikoshii hypothetical protein (1179 aa),fasta scores; E(): 0, 23.7% identity in 1217 aa overlap. Also shows weak similarity to coiled-coil-containing eukaryotic proteins involved in chromosome maintenance e.g. SW:XCPE_XENLA (EMBL:U13674), xcap-E, Xenopus laevis chromosome assembly protein (1203 aa), fasta scores; E(): 4.9e-16, 22.1% identity in 1198 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 716730 906716 NMA0724 Neisseria meningitidis Z2491 hypothetical protein YP_002342179.1 713245 D 122587 CDS YP_002342180.1 218767668 906717 complement(717081..718121) 1 NC_003116.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 718121 adhA 906717 adhA Neisseria meningitidis Z2491 alcohol dehydrogenase YP_002342180.1 717081 R 122587 CDS YP_002342181.1 218767669 906718 complement(718410..718799) 1 NC_003116.1 NMA0726, probable pilin, len: 129 aa; similar to many type IV pilins e.g. TR:Q60148 (EMBL:L76605), pilE,Pseudomonas aeruginosa fimbrial protein precursor (141 aa), fasta scores; E(): 1.8e-09, 37.5% identity in 128 aa overlap and TR:AAD27895 (EMBL:AF027189), comF,Acinetobacter sp. BD413 pilin-like competence factor involved in natural transformation (141 aa), fasta scores; E(): 3.9e-07, 34.9% identity in 126 aa overlap. Similar to NMA0424, fasta scores; E(): 2e-11, 32.8% identity in 131 aa overlap, NMA1110, fasta scores; E(): 4.1e-07, 31.9% identity in 141 aa overlap and NMA0264, fasta scores; E(): 4.3e-07, 41.2% identity in 68 aa overlap. Contains PS00409 Prokaryotic N-terminal methylation site and a probable N-terminal signal sequence; pilin 718799 906718 NMA0726 Neisseria meningitidis Z2491 pilin YP_002342181.1 718410 R 122587 CDS YP_002342182.1 218767670 906719 719025..720203 1 NC_003116.1 NMA0728, probable periplasmic protein, len: 392 aa; shows weak similarity to proteins encoding membrane transport functions e.g. SW:ACRA_ECOLI (EMBL:M94248),acrA, Escherichia coli acriflavin resistance protein (397 aa), fasta scores; E(): 1.3e-08, 26.9% identity in 338 aa overlap and SW:MTRC_NEIGO (EMBL:U14993), mtrC, Neisseria gonorrhoeae membrane fusion protein (412 aa), fasta scores; E(): 3.7e-07, 26.3% identity in 396 aa overlap. Contains probable N-terminal signal sequence; hypothetical protein 720203 906719 NMA0728 Neisseria meningitidis Z2491 hypothetical protein YP_002342182.1 719025 D 122587 CDS YP_002342183.1 218767671 906720 720269..722203 1 NC_003116.1 NMA0729, probable ABC transporter ATP-binding protein, len: 644 aa; similar to many e.g. SW:YBJZ_ECOLI (EMBL:AE000189), ybjZ, Escherichia coli hypothetical ABC transporter ATP-binding protein (648 aa), fasta scores; E(): 0, 52.2% identity in 648 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Contains hydrophobic, probable membrane-spanning regions; ABC transporter ATP-binding protein 722203 906720 NMA0729 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002342183.1 720269 D 122587 CDS YP_002342184.1 218767672 906721 complement(722619..723401) 1 NC_003116.1 NMA0730, thiol:disulphide interchange protein, len: 260 aa; shows weak similarity to thiol:disulphide interchange proteins e.g. SW:DSBC_ECOLI (EMBL:M54884), dsbC, Escherichia coli thiol:disulfide interchange protein (236 aa), fasta scores; E(): 1.6e-13,27.7% identity in 231 aa overlap and SW:DSBC_ERWCH (EMBL:X76687), dsbC, Erwinia chrysanthemi thiol:disulfide interchange protein (238 aa), fasta scores; E(): 4.1e-11,24.5% identity in 220 aa overlap. Contains a probable N-terminal signal sequence. Cys 148 and Cys 151 are conserved in known thiol:disulphide interchange proteins; thiol:disulfide interchange protein 723401 906721 NMA0730 Neisseria meningitidis Z2491 thiol:disulfide interchange protein YP_002342184.1 722619 R 122587 CDS YP_002342185.1 218767673 906722 723540..725729 1 NC_003116.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 725729 priA 906722 priA Neisseria meningitidis Z2491 primosome assembly protein PriA YP_002342185.1 723540 D 122587 CDS YP_002342186.1 218767674 906723 complement(725776..726849) 1 NC_003116.1 NMA0732, probable integral membrane protein, len: 357 aa; unknown, contains hydrophobic, probable membrane-spanning regions; integral membrane protein 726849 906723 NMA0732 Neisseria meningitidis Z2491 integral membrane protein YP_002342186.1 725776 R 122587 CDS YP_002342187.1 218767675 906724 complement(726897..727772) 1 NC_003116.1 NMA0733, probable transposase, len: 291 aa; similar to many e.g. similar to many e.g. TR:Q51474 (EMBL:M24471) Alteromonas atlantica CDS within insertion element IS492 which is involved in reversible inactivation of extracellular polysaccharide production (318 aa), fasta scores; E(): 1.6e-26, 34.8% identity in 267 aa overlap. Also shows weak similarity to pilin-inverting genes e.g. SW:PIV_MORLA (EMBL:M34367), piv, Moraxella acunata pilin gene inverting protein (322 aa), fasta scores; E(): 3.3e-11, 30.7% identity in 264 aa overlap. Highly similar to others from Neisseria meningitidis e.g. NMA1185, E(): 0, 94.3% identity in 279 aa overlap, also NMA2085. Contains Pfam match to entry PF01548 Transposase_9,Transposase; transposase 727772 906724 NMA0733 Neisseria meningitidis Z2491 transposase YP_002342187.1 726897 R 122587 CDS YP_002342188.1 218767676 906725 complement(727827..728777) 1 NC_003116.1 NMA0734, probable transposase for IS1106A3, len: 316 aa; similar to many e.g. TR:CAB44967 (EMBL:AJ242841),Neisseria meningitidis transposase for insertion sequence IS1106A3 (335 aa), fasta scores; E(): 0, 97.2% identity in 282 aa overlap; transposase for IS1106A3 728777 906725 NMA0734 Neisseria meningitidis Z2491 transposase for IS1106A3 YP_002342188.1 727827 R 122587 CDS YP_002342189.1 218767677 906727 complement(729844..731772) 1 NC_003116.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 731772 dnaK 906727 dnaK Neisseria meningitidis Z2491 molecular chaperone DnaK YP_002342189.1 729844 R 122587 CDS YP_002342190.1 218767678 906728 complement(731980..732252) 1 NC_003116.1 NMA0737, len: 90 aa; unknown; hypothetical protein 732252 906728 NMA0737 Neisseria meningitidis Z2491 hypothetical protein YP_002342190.1 731980 R 122587 CDS YP_002342191.1 218767679 906729 732438..733124 1 NC_003116.1 NMA0738, transcriptional regulator, len: 228 aa; shows weak similarity to phage repressors e.g. SW:RPC1_BPPH8 (EMBL:X13065) bacteriophage phi-80 repressor protein (235 aa), fasta scores; E(): 5.9e-11, 30.3% identity in 234 aa overlap. Also similar to other transcriptional regulators e.g. SW:PRTR_PSEAE (EMBL:D12706), prtR, Pseudomonas aeruginosa pyosin repressor protein (256 aa), fasta scores; E(): 2.5e-05,26.7% identity in 247 aa overlap. Similar to NMA1884,fasta scores; E(): 0, 53.4% identity in 232 aa overlap; transcriptional regulator 733124 906729 NMA0738 Neisseria meningitidis Z2491 transcriptional regulator YP_002342191.1 732438 D 122587 CDS YP_002342192.1 218767680 906730 733256..733594 1 NC_003116.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 733594 906730 NMA0739 Neisseria meningitidis Z2491 iron-sulfur cluster insertion protein ErpA YP_002342192.1 733256 D 122587 CDS YP_002342193.1 218767681 906731 733754..734218 1 NC_003116.1 NMA0740, len: 154 aa; unknown; hypothetical protein 734218 906731 NMA0740 Neisseria meningitidis Z2491 hypothetical protein YP_002342193.1 733754 D 122587 CDS YP_002342194.1 218767682 906732 734253..735764 1 NC_003116.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 735764 ubiB 906732 ubiB Neisseria meningitidis Z2491 ubiquinone biosynthesis protein UbiB YP_002342194.1 734253 D 122587 CDS YP_002342195.1 218767683 906733 complement(736121..736939) 1 NC_003116.1 NMA0742, cysE, probable serine acetyltransferase,len: 272 aa; similar to many e.g. SW:CYSE_ECOLI (EMBL:M15745), cysE, Escherichia coli serine acetyltransferase (EC 2.3.1.30) (273 aa), fasta scores; E(): 0, 57.0% identity in 251 aa overlap. Contains Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) and PS00101 Hexapeptide-repeat containing-transferases signature; serine acetyltransferase 736939 906733 NMA0742 Neisseria meningitidis Z2491 serine acetyltransferase YP_002342195.1 736121 R 122587 CDS YP_002342196.1 218767684 906734 737123..737701 1 NC_003116.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 737701 906734 NMA0744 Neisseria meningitidis Z2491 heat shock protein GrpE YP_002342196.1 737123 D 122587 CDS YP_002342197.1 218767685 906735 complement(737825..738040) 1 NC_003116.1 NMA0745, periplasmic protein, len: 71 aa; similar to SW:Y173_HAEIN (EMBL:U32702) Haemophilus influenzae hypothetical protein (86 aa), fasta scores; E(): 1.5e-10, 50.8% identity in 65 aa overlap. Contains a N-terminal signal sequence; hypothetical protein 738040 906735 NMA0745 Neisseria meningitidis Z2491 hypothetical protein YP_002342197.1 737825 R 122587 CDS YP_002342198.1 218767686 906736 complement(738066..739121) 1 NC_003116.1 NMA0746, apbE, probable thiamine biosynthesis protein, len: 351 aa; similar to e.g. SW:APBE_SALTY (EMBL:AF035376), apbE, Salmonella typhimurium thiamine biosynthesis lipoprotein apbE precursor (350 aa), fasta scores; E(): 0, 38.7% identity in 349 aa overlap. Contains a probable N-terminal signal sequence; thiamine biosynthesis protein 739121 906736 NMA0746 Neisseria meningitidis Z2491 thiamine biosynthesis protein YP_002342198.1 738066 R 122587 CDS YP_002342199.1 218767687 906737 complement(739274..740491) 1 NC_003116.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit F 740491 nqrF 906737 nqrF Neisseria meningitidis Z2491 Na(+)-translocating NADH-quinone reductase subunit F YP_002342199.1 739274 R 122587 CDS YP_002342200.1 218767688 906738 complement(740505..741098) 1 NC_003116.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.; Na(+)-translocating NADH-quinone reductase subunit E 741098 nqrE 906738 nqrE Neisseria meningitidis Z2491 Na(+)-translocating NADH-quinone reductase subunit E YP_002342200.1 740505 R 122587 CDS YP_002342201.1 218767689 906739 complement(741102..741728) 1 NC_003116.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit D 741728 nqrD 906739 nqrD Neisseria meningitidis Z2491 Na(+)-translocating NADH-quinone reductase subunit D YP_002342201.1 741102 R 122587 CDS YP_002342202.1 218767690 906740 complement(741728..742504) 1 NC_003116.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit C 742504 nqrC 906740 nqrC Neisseria meningitidis Z2491 Na(+)-translocating NADH-quinone reductase subunit C YP_002342202.1 741728 R 122587 CDS YP_002342203.1 218767691 906741 complement(742497..743729) 1 NC_003116.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit B 743729 nqrB 906741 nqrB Neisseria meningitidis Z2491 Na(+)-translocating NADH-quinone reductase subunit B YP_002342203.1 742497 R 122587 CDS YP_002342204.1 218767692 906742 complement(743732..745075) 1 NC_003116.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit A 745075 nqrA 906742 nqrA Neisseria meningitidis Z2491 Na(+)-translocating NADH-quinone reductase subunit A YP_002342204.1 743732 R 122587 CDS YP_002342205.1 218767693 906743 complement(745423..746844) 1 NC_003116.1 NMA0753, membrane protein, len: 473 aa; shows very weak similarity to SW:Y753_SYNY3 (EMBL:D90917) Synechocystis sp. (strain PCC 6803) hypothetical membrane protein (449 aa), fasta scores; E(): 1.7e-05, 23.9% identity in 481 aa overlap. Contains hydrophobic, membrane-spanning regions; hypothetical protein 746844 906743 NMA0753 Neisseria meningitidis Z2491 hypothetical protein YP_002342205.1 745423 R 122587 CDS YP_002342206.1 218767694 906744 complement(747202..747561) 1 NC_003116.1 NMA0754, membrane protein, len: 119 aa; similar to SW:YBAN_ECOLI (EMBL:AE000153), ybaN,Escherichia coli hypothetical protein, len: 125 aa, fasta scores; E(): 6.4e-17, 41.0% identity in 117 aa overlap and TR:Q51668 (EMBL:U34346) Paracoccus denitrificans hypothetical protein (fragment) (115 aa), fasta scores; E(): 8.5e-15, 36.5% identity in 115 aa overlap. Contains hydrophobic, membrane-spanning region; hypothetical protein 747561 906744 NMA0754 Neisseria meningitidis Z2491 hypothetical protein YP_002342206.1 747202 R 122587 CDS YP_002342207.1 218767695 906745 complement(747558..748163) 1 NC_003116.1 NMA0755, len: 201 aa; unknown; hypothetical protein 748163 906745 NMA0755 Neisseria meningitidis Z2491 hypothetical protein YP_002342207.1 747558 R 122587 CDS YP_002342208.1 218767696 906746 complement(748210..748692) 1 NC_003116.1 NMA0756, probable AsnC-family transcriptional regulator, len: 160 aa; similar to many e.g. SW:BKDR_PSEPU (EMBL:M57613), bkdR, Pseudomonas putida branched-chain keto acid dehydrogenase complex operon transcriptional regulator (161 aa), fasta scores; E(): 1.2e-23, 43.3% identity in 150 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg, AsnC family; AsnC-family transcriptional regulator 748692 906746 NMA0756 Neisseria meningitidis Z2491 AsnC-family transcriptional regulator YP_002342208.1 748210 R 122587 CDS YP_002342209.1 218767697 906748 749198..750304 1 NC_003116.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 750304 gcvT 906748 gcvT Neisseria meningitidis Z2491 glycine cleavage system aminomethyltransferase T YP_002342209.1 749198 D 122587 CDS YP_002342210.1 218767698 906749 750467..750853 1 NC_003116.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 750853 gcvH 906749 gcvH Neisseria meningitidis Z2491 glycine cleavage system protein H YP_002342210.1 750467 D 122587 CDS YP_002342211.1 218767699 906750 751005..752252 1 NC_003116.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 752252 hemA 906750 hemA Neisseria meningitidis Z2491 glutamyl-tRNA reductase YP_002342211.1 751005 D 122587 CDS YP_002342212.1 218767700 906751 752579..753100 1 NC_003116.1 NMA0761, regulatory protein, len: 173 aa; similar to the N-termini of several nosR proteins e.g. TR:O68483 (EMBL:AF047430), nosR, Sinorhizobium meliloti regulatory protein (755 aa), fasta scores; E(): 1.8e-12,38.3% identity in 115 aa overlap; regulatory protein 753100 906751 NMA0761 Neisseria meningitidis Z2491 regulatory protein YP_002342212.1 752579 D 122587 CDS YP_002342213.1 218767701 906752 753154..754188 1 NC_003116.1 NMA0762, hypothetical protein, len: 344 aa; unknown function, similar to part of several nosD proteins e.g. SW:NOSD_PSEST (EMBL:X53676), nosD, Pseudomonas stutzeri copper-binding periplasmic protein precursor (436 aa),fasta scores; E(): 9.8e-29, 39.0% identity in 331 aa overlap; hypothetical protein 754188 906752 NMA0762 Neisseria meningitidis Z2491 hypothetical protein YP_002342213.1 753154 D 122587 CDS YP_002342214.1 218767702 906753 754216..754866 1 NC_003116.1 NMA0763, probable ABC-transporter ATP-binding protein, len: 216 aa; similar to many ABC-transporter ATP-binding proteins e.g. SW:NOSF_PSEST (EMBL:X53676),nosF, Pseudomonas stutzeri copper transport ATP-binding protein (308 aa), fasta scores; E(): 5.2e-33, 50.5% identity in 200 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); ABC transporter ATP-binding protein 754866 906753 NMA0763 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002342214.1 754216 D 122587 CDS YP_002342215.1 218767703 906755 755084..755578 1 NC_003116.1 NMA0765, lipoprotein, len: 164 aa; similar to several nosL proteins e.g. TR:O07331 (EMBL:U94899),nosL, Sinorhizobium meliloti outer-membrane lipoprotein (185 aa), fasta scores; E(): 2.4e-27, 45.1% identity in 164 aa overlap. Contains probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 755578 906755 NMA0765 Neisseria meningitidis Z2491 lipoprotein YP_002342215.1 755084 D 122587 CDS YP_002342216.1 218767704 906756 complement(755666..757327) 1 NC_003116.1 NMA0766, probable electron transfer flavoprotein-ubiquinone oxidoreductase, len: 553 aa; similar to many eukaryotic enzymes e.g. SW:ETFD_HUMAN (EMBL:S69232), etfdH, Homo sapiens electron transfer flavoprotein-ubiquinone oxidoreductase precursor (EC 1.5.5.1) (617 aa), fasta scores; E(): 0, 56.6% identity in 558 aa overlap. Also shows weaker similarity to several bacterial fixC proteins e.g. SW:FIXC_AZOCA (EMBL:X55450),fixC, Azorhizobium caulinodans electron transfer quinone reductase (435 aa), fasta scores; E(): 3.4e-11,24.6% identity in 398 aa overlap; electron transfer flavoprotein-ubiquinone oxidoreductase 757327 906756 NMA0766 Neisseria meningitidis Z2491 electron transfer flavoprotein-ubiquinone oxidoreductase YP_002342216.1 755666 R 122587 CDS YP_002342217.1 218767705 906757 complement(757457..757873) 1 NC_003116.1 NMA0767, unknown, len: 138 aa; shows weak similarity to part of TR:O53037 (EMBL:U68399), hmcC,Haemophilus influenzae protein implicated in haemocin production (198 aa), fasta scores; E(): 1.1e-06, 30.9% identity in 110 aa overlap. Also highly similar to other proteins from Neisseria meningitidis, NMA0173, fasta scores; 70.7% identity in 164 aa overlap and NMA1066,fasta scores; 88.3% identity in 128 aa overlap; hypothetical protein 757873 906757 NMA0767 Neisseria meningitidis Z2491 hypothetical protein YP_002342217.1 757457 R 122587 CDS YP_002342218.1 218767706 906758 758873..759838 1 NC_003116.1 NMA0768, probable transposase for IS1655, len: 321 aa; similar to many e.g. SW:TRA4_BACFR (EMBL:M17808) Bacteroides fragilis transposase for insertion sequence element (326 aa), fasta scores; E(): 0, 41.6% identity in 310 aa overlap. Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family. Contains probable helix-turn-helix motif at aa 22-34 (Score 1705, +4.99 SD); transposase for IS1655 759838 906758 NMA0768 Neisseria meningitidis Z2491 transposase for IS1655 YP_002342218.1 758873 D 122587 CDS YP_002342219.1 218767707 906759 complement(760370..761023) 1 NC_003116.1 NMA0769, transposase for IS1016, len: 217 aa; similar to many e.g. TR:Q48234 (EMBL:X59756) ORF from Haemophilus influenzae insertion sequence IS1016-V6 (191 aa), fasta scores; E(): 0, 66.5% identity in 188 aa overlap; transposase for IS1016 761023 906759 NMA0769 Neisseria meningitidis Z2491 transposase for IS1016 YP_002342219.1 760370 R 122587 CDS YP_002342220.1 218767708 906762 complement(761709..762674) 1 NC_003116.1 NMA0772, probable DNA-invertase, len: 321 aa; similar to site-specific pilin-gene invertases from Moraxella e.g. SW:PIV_MORBO (EMBL:M32345), piv, Moraxella bovis pilin gene inverting protein (322 aa), fasta scores; E(): 2.8e-23, 30.0% identity in 320 aa overlap. Also similar to TR:P72078 (EMBL:U65994) Neisseria gonorrhoeae pilin gene inverting protein homolog (320 aa), fasta scores; E(): 0, 47.1% identity in 323 aa overlap. Similar to others from Neisseria meningitidis e.g. NMA1800 (318 aa), fasta scores; E(): 0, 40.9% identity in 318 aa overlap. Contains Pfam match to entry PF01548 Transposase_9, Transposase; DNA-invertase 762674 906762 NMA0772 Neisseria meningitidis Z2491 DNA-invertase YP_002342220.1 761709 R 122587 CDS YP_002342221.1 218767709 906763 762890..763138 1 NC_003116.1 NMA0773, len: 82 aa; unknown; hypothetical protein 763138 906763 NMA0773 Neisseria meningitidis Z2491 hypothetical protein YP_002342221.1 762890 D 122587 CDS YP_002342222.1 218767710 906764 complement(763535..764593) 1 NC_003116.1 NMA0774, unknown, len: 352 aa; similar to hypothetical proteins from bacteriophage and plasmids e.g. TR:O82966 (EMBL:AB015669) ORFC6 from Burkholderia solanacearum plasmid pJTPS1 (364 aa), fasta scores; E(): 9.7e-24, 30.9% identity in 366 aa overlap and TR:Q38198 (EMBL:M57538) unknown protein from bacteriophage Cf1c (388 aa), fasta scores; E(): 1.2e-16, 25.5% identity in 357 aa overlap. Similar to NMA1799, fasta scores; E(): 0, 40.4% identity in 369 aa overlap. Contains 2 PS00017 ATP/GTP-binding site motif A (P-loop), which may be fortuitous; hypothetical protein 764593 906764 NMA0774 Neisseria meningitidis Z2491 hypothetical protein YP_002342222.1 763535 R 122587 CDS YP_002342223.1 218767711 906765 complement(764596..764883) 1 NC_003116.1 NMA0775, integral membrane protein, len: 95 aa; unknown, shows weak similarity to NMA1798, fasta scores; E(): 4.5e-07, 34.8% identity in 92 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein 764883 906765 NMA0775 Neisseria meningitidis Z2491 integral membrane protein YP_002342223.1 764596 R 122587 CDS YP_002342224.1 218767712 906766 complement(764885..766399) 1 NC_003116.1 NMA0776, probable cell-surface protein, len; 504 aa; highly similar to TR:O87783 (EMBL:AJ010115), tspB,Neisseria meningitidis strain B:15:P1.16 T-cell and B-cell antigen (partial CDS) (504 aa), fasta scores; E(): 0,54.8% identity in 485 aa overlap. Similar to others from Neisseria meningitidis, NMA1797, fasta scores; E(): 0,58.4% identity in 474 aa overlap, NMA1173, fasta scores; E(): 2.9e-21, 51.0% identity in 145 aa overlap and NMA2005, fasta scores; E(): 8.6e-19, 61.5% identity in 96 aa overlap. Contains a probable N-terminal signal sequence; cell-surface protein 766399 906766 NMA0776 Neisseria meningitidis Z2491 cell-surface protein YP_002342224.1 764885 R 122587 CDS YP_002342225.1 218767713 906767 complement(766341..766646) 1 NC_003116.1 NMA0777, len: 101 aa; unknown, similar to others from Neisseria meningitidis, NMA1172, fasta scores; E(): 5.1e-16, 57.5% identity in 73 aa overlap and NMA2004,fasta scores; E(): 1.8e-14, 47.6% identity in 105 aa overlap; hypothetical protein 766646 906767 NMA0777 Neisseria meningitidis Z2491 hypothetical protein YP_002342225.1 766341 R 122587 CDS YP_002342226.1 218767714 906768 complement(766775..767050) 1 NC_003116.1 NMA0778, unknown, len: 91 aa; shows weak similarity to TR:O82955 (EMBL:AB015669) ORF C4 from Burkholderia solanacearum plasmid pJTPS1 (111 aa), fasta scores; E(): 0.0061, 26.0% identity in 104 aa overlap. Similar to others from Neisseria meningitidis, NMA1171, fasta scores; E(): 3.1e-25, 58.7% identity in 92 aa overlap, NMA2003,fasta scores; E(): 3.1e-25, 58.7% identity in 92 aa overlap and NMA1796, fasta scores; E(): 5.9e-10, 30.4% identity in 92 aa overlap; hypothetical protein 767050 906768 NMA0778 Neisseria meningitidis Z2491 hypothetical protein YP_002342226.1 766775 R 122587 CDS YP_002342227.1 218767715 906769 complement(767061..767279) 1 NC_003116.1 NMA0779, integral membrane protein, len: 72 aa; similar to TR:O88142 (EMBL:AB012574), vpf77,hypothetical protein from Vibrio parahaemolyticus filamentous bacteriophage Vf12 (77 aa), fasta scores; E(): 0.64, 32.0% identity in 75 aa overlap. Similar to others from Neisseria meningitidis, NMA2002, fasta scores; E(): 2.8e-18, 72.2% identity in 72 aa overlap and NMA1170,fasta scores; E(): 2.8e-18, 72.2% identity in 72 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein 767279 906769 NMA0779 Neisseria meningitidis Z2491 integral membrane protein YP_002342227.1 767061 R 122587 CDS YP_002342228.1 218767716 906770 complement(767362..767565) 1 NC_003116.1 NMA0780, len: 67 aa; unknown, similar to others from Neisseria meningitidis, NMA1794, fasta scores; E(): 2.6e-20, 58.5% identity in 65 aa overlap and NMA1169,fasta scores; E(): 3e-07, 36.1% identity in 61 aa overlap and NMA2001, fasta scores; E(): 3e-07, 36.1% identity in 61 aa overlap; hypothetical protein 767565 906770 NMA0780 Neisseria meningitidis Z2491 hypothetical protein YP_002342228.1 767362 R 122587 CDS YP_002342229.1 218767717 906771 complement(767583..767894) 1 NC_003116.1 NMA0781, len: 103 aa; unknown, similar to others from Neisseria meningitidis, NMA1793, fasta scores; E(): 2.6e-30, 70.1% identity in 97 aa overlap, NMA1168, fasta scores; E(): 4.9e-11, 34.9% identity in 83 aa overlap and NMA2000, fasta scores; E(): 4.9e-11, 34.9% identity in 83 aa overlap; hypothetical protein 767894 906771 NMA0781 Neisseria meningitidis Z2491 hypothetical protein YP_002342229.1 767583 R 122587 CDS YP_002342230.1 218767718 906772 complement(767915..769264) 1 NC_003116.1 NMA0782, phage replication protein, len: 449 aa; shows weak similarity to e.g. TR:O34630 (EMBL:U83796) rstA2, Vibrio cholerae bacteriophage CTXphi protein required for replication and integration (359 aa),fasta scores; E(): 4.5e-10, 27.0% identity in 296 aa overlap. Also similar to TR:O82959 (EMBL:AB015669) ORF C7 from Burkholderia solanacearum plasmid pJTPS1 (444 aa),fasta scores; E (): 3.4e-15, 31.6% identity in 326 aa overlap. Similar to others from Neisseria meningitidis,NMA1792, E(): 0, 50.4% identity in 407 aa overlap,NMA1999, fasta scores; E(): 0, 42.7% identity in 337 aa overlap, and NMA1167, fasta scores; E(): 0, 42.7% identity in 337 aa overlap; phage replication protein 769264 906772 NMA0782 Neisseria meningitidis Z2491 phage replication protein YP_002342230.1 767915 R 122587 CDS YP_002342231.1 218767719 906773 complement(769261..769476) 1 NC_003116.1 NMA0783, len: 71 aa; unknown; hypothetical protein 769476 906773 NMA0783 Neisseria meningitidis Z2491 hypothetical protein YP_002342231.1 769261 R 122587 CDS YP_002342232.1 218767720 906774 769762..770283 1 NC_003116.1 NMA0784, membrane protein, len: 173 aa; unknown, similar to others from Neisseria meningitidis,NMA1989, fasta scores; E(): 0, 82.7% identity in 173 aa overlap and NMA0786, fasta scores; E(): 0, 50.0% identity in 168 aa overlap. Within a region of unusually low GC content. Contains hydrophobic, membrane-spanning regions; membrane protein 770283 906774 NMA0784 Neisseria meningitidis Z2491 membrane protein YP_002342232.1 769762 D 122587 CDS YP_002342233.1 218767721 906775 770333..770782 1 NC_003116.1 NMA0785, len: 149 aa; unknown, similar to the N-terminal half of NMA0787, fasta scores; E(): 4.3e-33,73.5% identity in 132 aa overlap. Within a region of unusually low GC content; hypothetical protein 770782 906775 NMA0785 Neisseria meningitidis Z2491 hypothetical protein YP_002342233.1 770333 D 122587 CDS YP_002342234.1 218767722 906776 770816..771322 1 NC_003116.1 NMA0786, membrane protein, len: 168 aa; unknown, similar to NMA0784, fasta scores; E(): 0, 50.0% identity in 168 aa overlap and NMA1989, fasta scores; E(): 0, 47.6% identity in 168 aa overlap. Within a region of unusually low GC content. Contains hydrophobic, membrane-spanning regions; membrane protein 771322 906776 NMA0786 Neisseria meningitidis Z2491 membrane protein YP_002342234.1 770816 D 122587 CDS YP_002342235.1 218767723 906779 complement(774834..775760) 1 NC_003116.1 NMA0789, probable periplasmic binding protein, len: 308 aa; similar to binding protein components of ABC-transporters and to other binding proteins such as adhesins e.g. SW:ZNUA_ECOLI (EMBL:U38702), znuA,Escherichia coli high-affinity zinc uptake system component (328 aa), fasta scores; E(): 1.4e-13, 27.1% identity in 292 aa overlap and SW:ADHS_STRPA (EMBL:M26130), fimA, Streptococcus parasanguis adhesin B precursor (309 aa), fasta scores; E(): 1.2e-13, 26.0% identity in 304 aa overlap. Contains HD repeats from aa 115-134. Contains Pfam match to entry PF01297 Lipoprotein_4, Adhesion lipoprotein and probable N-terminal signal sequence; periplasmic binding protein 775760 906779 NMA0789 Neisseria meningitidis Z2491 periplasmic binding protein YP_002342235.1 774834 R 122587 CDS YP_002342236.1 218767724 906780 complement(775837..776712) 1 NC_003116.1 NMA0790, probable ABC-transporter membrane protein,len: 291 aa; similar to many e.g. SW:MNTB_SYNY3 (EMBL:L34630), mntB, Synechocystis sp. (strain PCC 6803) manganese transport system membrane protein (306 aa),fasta scores; E(): 2.7e-21, 27.9% identity in 280 aa overlap. Contains Pfam match to entry PF00950 ABC-3, ABC 3 transport family and contains hydrophobic, membrane-spanning regions; ABC-transporter membrane protein 776712 906780 NMA0790 Neisseria meningitidis Z2491 ABC-transporter membrane protein YP_002342236.1 775837 R 122587 CDS YP_002342237.1 218767725 906781 complement(776748..777503) 1 NC_003116.1 NMA0791, probable ABC-transporter ATP-binding protein, len: 251 aa; similar to many e.g. SW:MNTA_SYNY3 (EMBL:L34630), mntA, Synechocystis sp. (strain PCC 6803) manganese transport system ATP-binding protein (260 aa),fasta scores; E(): 2.7e-27, 38.8% identity in 232 aa overlap. Contains Pfam match to entry PF00005 ABC_tran,ABC transporter and PS00017 ATP/GTP-binding site motif A (P-loop); ABC transporter ATP-binding protein 777503 906781 NMA0791 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002342237.1 776748 R 122587 CDS YP_002342238.1 218767726 906782 complement(777791..778156) 1 NC_003116.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 778156 rplS 906782 rplS Neisseria meningitidis Z2491 50S ribosomal protein L19 YP_002342238.1 777791 R 122587 CDS YP_002342239.1 218767727 906783 complement(778172..778921) 1 NC_003116.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 778921 trmD 906783 trmD Neisseria meningitidis Z2491 tRNA (guanine-N(1)-)-methyltransferase YP_002342239.1 778172 R 122587 CDS YP_002342240.1 218767728 906784 complement(778921..779430) 1 NC_003116.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 779430 rimM 906784 rimM Neisseria meningitidis Z2491 16S rRNA-processing protein RimM YP_002342240.1 778921 R 122587 CDS YP_002342241.1 218767729 906785 complement(779446..779691) 1 NC_003116.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 779691 rpsP 906785 rpsP Neisseria meningitidis Z2491 30S ribosomal protein S16 YP_002342241.1 779446 R 122587 CDS YP_002342242.1 218767730 906786 complement(779736..782162) 1 NC_003116.1 NMA0796, unknown, len: 808 aa; shows weak similarity in the N-terminal half to acyl-CoA synthetases e.g. TR:Q9ZER2 (EMBL:AJ012480) Pseudomonas mendocina pimeloyl-CoA synthetase (711 aa), fasta scores; E(): 3.3e-07, 22.0% identity in 496 aa overlap. Also similar to in part to many hypothetical proteins. The C-terminus contains a Pfam match to entry PF00583 Acetyltransf,Acetyltransferase (GNAT) family; hypothetical protein 782162 906786 NMA0796 Neisseria meningitidis Z2491 hypothetical protein YP_002342242.1 779736 R 122587 CDS YP_002342243.1 218767731 906787 complement(782280..783686) 1 NC_003116.1 NMA0797, probable two-component system sensor kinase, len: 468 aa; similar to many e.g. SW:BAES_ECOLI (EMBL:D14054), baeS, Escherichia coli sensor protein (EC 2.7.3.-) (467 aa), fasta scores; E(): 1.1e-21, 28.0% identity in 300 aa overlap. Contains Pfam matches to entry PF00512 signal, Signal carboxyl-terminal domain and to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains hydrophobic, probable membrane-spanning regions; two-component system sensor kinase 783686 906787 NMA0797 Neisseria meningitidis Z2491 two-component system sensor kinase YP_002342243.1 782280 R 122587 CDS YP_002342244.1 218767732 906788 complement(783700..784377) 1 NC_003116.1 NMA0798, probable two-component system regulator,len: 225 aa; similar to many e.g. SW:OMPR_ECOLI (EMBL:J01656), ompR, Escherichia coli transcriptional regulatory protein (239 aa), fasta scores; E(): 1.7e-28,41.8% identity in 232 aa overlap. Contains Pfam matches to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal and to entry PF00072 response_reg,Response regulator receiver domain; two-component system regulator 784377 906788 NMA0798 Neisseria meningitidis Z2491 two-component system regulator YP_002342244.1 783700 R 122587 CDS YP_002342245.1 218767733 906790 complement(784567..786381) 1 NC_003116.1 NMA0800, integral membrane protein, len: 604 aa; unknown, shows very weak similarity to the N-terminal half of TR:AAD35888 (EMBL:AE001748) Thermotoga maritima hypothetical protein (1065 aa), fasta scores; E(): 0.014, 21.7% identity in 465 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein 786381 906790 NMA0800 Neisseria meningitidis Z2491 integral membrane protein YP_002342245.1 784567 R 122587 CDS YP_002342246.1 218767734 906791 complement(786371..786724) 1 NC_003116.1 NMA0801, len: 117 aa; unknown; hypothetical protein 786724 906791 NMA0801 Neisseria meningitidis Z2491 hypothetical protein YP_002342246.1 786371 R 122587 CDS YP_002342247.1 218767735 906792 complement(786740..787345) 1 NC_003116.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 787345 906792 NMA0802 Neisseria meningitidis Z2491 Maf-like protein YP_002342247.1 786740 R 122587 CDS YP_002342248.1 218767736 906793 complement(787398..788168) 1 NC_003116.1 NMA0803, tatC, probable sec-independent protein translocase component, len: 256 aa; similar to many e.g. SW:TATC_ECOLI (EMBL:AJ005830), tatC, mttB, Escherichia coli sec-independent protein translocase (258 aa),fasta scores; E(): 0, 50.2% identity in 247 aa overlap. Contains Pfam match to entry PF00902 UPF0032, MttB family. Contains hydrophobic, membrane-spanning regions; sec-independent protein translocase component 788168 906793 NMA0803 Neisseria meningitidis Z2491 sec-independent protein translocase component YP_002342248.1 787398 R 122587 CDS YP_002342249.1 218767737 906794 complement(788182..788868) 1 NC_003116.1 NMA0804, sec-independent protein translocase component, len: 228 aa; the hydrophobic N-terminus is similar to the N-terminus of TR:O69415 (EMBL:AJ005830), tatB, Escherichia coli sec-independent protein translocase component (171 aa), fasta scores; E(): 0.0011, 38.6% identity in 70 aa overlap. This region is also similar to N-termini from several hypothetical proteins; sec-independent protein translocase component 788868 906794 NMA0804 Neisseria meningitidis Z2491 sec-independent protein translocase component YP_002342249.1 788182 R 122587 CDS YP_002342250.1 218767738 906796 complement(789122..789445) 1 NC_003116.1 NMA0806, nucleotide-binding protein, len: 107 aa; similar to members of the HIT (histidine triad) family e.g. SW:IPK1_RABIT (EMBL:Y11175), hinT, Oryctolagus cuniculus HinT protein (125 aa), fasta scores; E(): 5e-15,40.2% identity in 102 aa overlap. Highly similar to SW:HITA_NEIGO (EMBL:AF003550), hitA, Neisseria gonorrhoeae HitA protein (107 aa), fasta scores; E(): 0, 96.3% identity in 107 aa overlap. Contains Pfam match to entry PF01230 HIT, HIT family and PS00892 HIT family signature; nucleotide-binding protein 789445 906796 NMA0806 Neisseria meningitidis Z2491 nucleotide-binding protein YP_002342250.1 789122 R 122587 CDS YP_002342251.1 218767739 906797 complement(789517..789840) 1 NC_003116.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 789840 hisE 906797 hisE Neisseria meningitidis Z2491 phosphoribosyl-ATP pyrophosphatase YP_002342251.1 789517 R 122587 CDS YP_002342252.1 218767740 906798 complement(789981..791045) 1 NC_003116.1 NMA0808, probable zinc-binding alcohol dehydrogenase, len: 354 aa; similar to many e.g. TR:Q59696 (EMBL:L35343), adh, Pseudomonas putida 2,3-butanediol dehydrogenase (EC 1.1.1.4) (362 aa), fasta scores; E(): 0,38.2% identity in 356 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases and PS00059 Zinc-containing alcohol dehydrogenases signature; zinc-binding alcohol dehydrogenase 791045 906798 NMA0808 Neisseria meningitidis Z2491 zinc-binding alcohol dehydrogenase YP_002342252.1 789981 R 122587 CDS YP_002342253.1 218767741 906799 complement(791408..792565) 1 NC_003116.1 NMA0810, len: 385 aa; unknown, similar to members of the histone deacetylase/acetoin utilization/acetylpolyamine aminohydrolase family e.g. SW:Y245_SYNY3 (EMBL:D90900) Synechocystis sp. (strain PCC 6803) hypothetical protein (304 aa), fasta scores; E(): 8.2e-33, 35.7% identity in 300 aa overlap. Contains Pfam match to entry PF00850 Hist_deacetyl, Histone deacetylase family; hypothetical protein 792565 906799 NMA0810 Neisseria meningitidis Z2491 hypothetical protein YP_002342253.1 791408 R 122587 CDS YP_002342254.1 218767742 906800 792645..792911 1 NC_003116.1 NMA0811, len: 88 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YAJC_ECOLI (EMBL:EG11096),yajC, Escherichia coli hypothetical protein (110 aa),fasta scores; E(): 6.9e-07, 35.2% identity in 88 aa overlap; hypothetical protein 792911 906800 NMA0811 Neisseria meningitidis Z2491 hypothetical protein YP_002342254.1 792645 D 122587 CDS YP_002342255.1 218767743 906801 793120..794976 1 NC_003116.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 794976 secD 906801 secD Neisseria meningitidis Z2491 preprotein translocase subunit SecD YP_002342255.1 793120 D 122587 CDS YP_002342256.1 218767744 906802 794980..795915 1 NC_003116.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 795915 secF 906802 secF Neisseria meningitidis Z2491 preprotein translocase subunit SecF YP_002342256.1 794980 D 122587 CDS YP_002342257.1 218767745 906804 796138..796407 1 NC_003116.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 796407 rpsO 906804 rpsO Neisseria meningitidis Z2491 30S ribosomal protein S15 YP_002342257.1 796138 D 122587 CDS YP_002342258.1 218767746 906805 796788..797912 1 NC_003116.1 NMA0816, probable polyamine permease ATP-binding protein, len: 374 aa; similar to ATP-binding components of many polyamine permeases e.g. SW:POTG_ECOLI (EMBL:M93239),potG, Escherichia coli putrescine transport ATP-binding protein (404 aa), fasta scores; E(): 0, 54.2% identity in 395 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); polyamine permease ATP-binding protein 797912 906805 NMA0816 Neisseria meningitidis Z2491 polyamine permease ATP-binding protein YP_002342258.1 796788 D 122587 CDS YP_002342259.1 218767747 906806 797928..798893 1 NC_003116.1 NMA0817, probable polyamine permease inner membrane protein, len: 321 aa; similar to inner membrane components from many polyamine permeases e.g. SW:POTH_ECOLI (EMBL:M93239), potH, Escherichia coli putrescine transport system permease (317 aa), fasta scores; E(): 0,49.2% identity in 311 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains hydrophobic, probable membrane-spanning regions; polyamine permease inner membrane protein 798893 906806 NMA0817 Neisseria meningitidis Z2491 polyamine permease inner membrane protein YP_002342259.1 797928 D 122587 CDS YP_002342260.1 218767748 906807 798893..799780 1 NC_003116.1 NMA0818, probable polyamine permease inner membrane protein, len: 295 aa; similar to inner membrane components from many polyamine permeases e.g. SW:POTI_ECOLI (EMBL:M93239), potI, Escherichia coli putrescine transport system permease (281 aa), fasta scores; E(): 0,54.7% identity in 278 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains hydrophobic, probable membrane-spanning regions; polyamine permease inner membrane protein 799780 906807 NMA0818 Neisseria meningitidis Z2491 polyamine permease inner membrane protein YP_002342260.1 798893 D 122587 CDS YP_002342261.1 218767749 906808 799906..801201 1 NC_003116.1 NMA0819, oxidoreductase, len: 431 aa; shows very weak similarity to several known oxidoreductases e.g. SW:SAOX_CORS1 (EMBL:U23955), soxB,Corynebacterium sp. sarcosine oxidase beta subunit (EC 1.5.3.1) (405 aa), fasta scores; E(): 6.8e-05, 23.7% identity in 414 aa overlap. Also similar to SW:ORDL_ECOLI (EMBL:U38543), ordL, Escherichia coli probable oxidoreductase (426 aa), fasta scores; E(): 0, 46.2% identity in 433 aa overlap; oxidoreductase 801201 906808 NMA0819 Neisseria meningitidis Z2491 oxidoreductase YP_002342261.1 799906 D 122587 CDS YP_002342262.1 218767750 906809 complement(801446..802750) 1 NC_003116.1 NMA0820, amtB, probable ammonium transporter, len: 434 aa; similar to many of bacterial and eukaryotic origin e.g. TR:O67997 (EMBL:AF005275), amtB, Azospirillum brasilense (Methyl)ammonium transporter (438 aa), fasta scores; E(): 0, 54.7% identity in 428 aa overlap. Contains Pfam match to entry PF00909 Ammonium_transp, Ammonium Transporter Family and PS01219 Ammonium transporters signature. Contains hydrophobic, membrane-spanning regions; ammonium transporter 802750 906809 NMA0820 Neisseria meningitidis Z2491 ammonium transporter YP_002342262.1 801446 R 122587 CDS YP_002342263.1 218767751 906814 complement(805239..806498) 1 NC_003116.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 806498 rho 906814 rho Neisseria meningitidis Z2491 transcription termination factor Rho YP_002342263.1 805239 R 122587 CDS YP_002342264.1 218767752 906815 complement(806718..809102) 1 NC_003116.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 809102 ppsA 906815 ppsA Neisseria meningitidis Z2491 phosphoenolpyruvate synthase YP_002342264.1 806718 R 122587 CDS YP_002342265.1 218767753 906816 809514..810335 1 NC_003116.1 NMA0827, len: 273 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YDIA_ECOLI (EMBL:AE000265) Escherichia coli hypothetical protein (277 aa), fasta scores; E(): 0, 47.4% identity in 270 aa overlap and to the C-terminal half of TR:O49562 (EMBL:AL021960) Arabidopsis thaliana hypothetical protein (403 aa), fasta scores; E(): 3.1e-16, 27.8% identity in 288 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 810335 906816 NMA0827 Neisseria meningitidis Z2491 hypothetical protein YP_002342265.1 809514 D 122587 CDS YP_002342266.1 218767754 906817 complement(810575..811237) 1 NC_003116.1 NMA0828, probable phosphatase, len: 220 aa; similar to many e.g. SW:GPHP_ALCEU (EMBL:M68905), cbbzP,Alcaligenes eutrophus phosphoglycolate phosphatase (231 aa), fasta scores; E(): 1.4e-13, 32.3% identity in 192 aa overlap and to phosphatases found within polyketide biosynthesis operons e.g. TR:AAD31837 (EMBL:AF131879), ansH, Streptomyces collinus phosphatase (268 aa), fasta scores; E(): 1.1e-11, 30.1% identity in 216 aa overlap. Also similar to NMA1688, fasta scores; E(): 2e-11, 27.8% identity in 227 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase; phosphatase 811237 906817 NMA0828 Neisseria meningitidis Z2491 phosphatase YP_002342266.1 810575 R 122587 CDS YP_002342267.1 218767755 906818 complement(811250..812077) 1 NC_003116.1 NMA0829, len: 275 aa; unknown, similar to SW:Y077_HAEIN (EMBL:U32693) Haemophilus influenzae hypothetical protein (288 aa), fasta scores; E(): 0, 48.9% identity in 272 aa overlap; hypothetical protein 812077 906818 NMA0829 Neisseria meningitidis Z2491 hypothetical protein YP_002342267.1 811250 R 122587 CDS YP_002342268.1 218767756 906819 812507..813130 1 NC_003116.1 NMA0830, periplasmic carrier protein, len: 207 aa; similar to e.g. SW:LOLA_ECOLI (EMBL:D49398), lolA,Escherichia coli outer membrane lipoproteins carrier protein precursor (204 aa), fasta scores; E(): 2.2e-11,29.4% identity in 197 aa overlap. Contains a N-terminal signal sequence; periplasmic carrier protein 813130 906819 NMA0830 Neisseria meningitidis Z2491 periplasmic carrier protein YP_002342268.1 812507 D 122587 CDS YP_002342269.1 218767757 906820 813403..814542 1 NC_003116.1 NMA0831, polyamine permease substrate-binding protein, len: 379 aa; similar to SW:POTF_ECOLI (EMBL:M93239), potF, Escherichia coli putrescine-binding periplasmic protein precursor (370 aa),fasta scores; E(): 0, 40.8% identity in 346 aa overlap. Also similar to NMA1786, fasta scores; E(): 0, 60.8% identity in 380 aa overlap and NMA2023, fasta scores; E(): 0, 54.8% identity in 396 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; polyamine permease substrate-binding protein 814542 906820 NMA0831 Neisseria meningitidis Z2491 polyamine permease substrate-binding protein YP_002342269.1 813403 D 122587 CDS YP_002342270.1 218767758 906821 814675..815826 1 NC_003116.1 NMA0832, glycosyl transferase, len: 383 aa; shows very weak similarity to several glycosyltransferases (some ) associated with capsule polysaccharide formation in pathogenic bacteria e.g. TR:AAD24457 (EMBL:AF118389), cps2K, Streptococcus suis glycosyl transferase (276 aa), fasta scores; E(): 1.6e-07, 25.7% identity in 335 aa overlap. Contains 9x NNKQQTT repeats and has an unusually low GC content (31%). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; glycosyl transferase family protein 815826 906821 NMA0832 Neisseria meningitidis Z2491 glycosyl transferase family protein YP_002342270.1 814675 D 122587 CDS YP_002342271.1 218767759 906822 815867..816397 1 NC_003116.1 NMA0833, len: 176 aa; unknown, similar to many hypothetical proteins e.g. part of SW:YRDA_ECOLI (EMBL:U18997) Escherichia coli hypothetical protein (256 aa), fasta scores; E(): 0, 62.4% identity in 173 aa overlap and to part of SW:CAIE_ECOLI (EMBL:X73904), caiE,Escherichia coli carnitine operon protein (203 aa), fasta scores; E(): 6.3e-16, 34.1% identity in 164 aa overlap. Contains a weak Pfam matches to entry PF00132 hexapep,Bacterial transferase hexapeptide (four repeats); hypothetical protein 816397 906822 NMA0833 Neisseria meningitidis Z2491 hypothetical protein YP_002342271.1 815867 D 122587 CDS YP_002342272.1 218767760 906824 complement(816773..818368) 1 NC_003116.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 818368 prfC 906824 prfC Neisseria meningitidis Z2491 peptide chain release factor 3 YP_002342272.1 816773 R 122587 CDS YP_002342273.1 218767761 906825 complement(818475..818870) 1 NC_003116.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 818870 hisI 906825 hisI Neisseria meningitidis Z2491 phosphoribosyl-AMP cyclohydrolase YP_002342273.1 818475 R 122587 CDS YP_002342274.1 218767762 906826 complement(818901..819668) 1 NC_003116.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 819668 hisF 906826 hisF Neisseria meningitidis Z2491 imidazole glycerol phosphate synthase subunit HisF YP_002342274.1 818901 R 122587 CDS YP_002342275.1 218767763 906827 complement(819681..820418) 1 NC_003116.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 820418 hisA 906827 hisA Neisseria meningitidis Z2491 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_002342275.1 819681 R 122587 CDS YP_002342276.1 218767764 906828 complement(820451..821089) 1 NC_003116.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 821089 hisH 906828 hisH Neisseria meningitidis Z2491 imidazole glycerol phosphate synthase subunit HisH YP_002342276.1 820451 R 122587 CDS YP_002342277.1 218767765 906829 complement(821220..822722) 1 NC_003116.1 NMA0841, probable phosphate acyltransferase, len: 500 aa; similar to many phosphate acetyltransferases,except over the N-terminal approx. 200 aa e.g. SW:PTA_ECOLI (EMBL:D17576), pta, Escherichia coli phosphate acetyltransferase (EC 2.3.1.8) (713 aa), fasta scores; E(): 0, 67.6% identity in 346 aa overlap. Contains Pfam match to entry PF01515 PTA_PTB, Phosphate acetyl/butaryl transferase; phosphate acyltransferase 822722 906829 NMA0841 Neisseria meningitidis Z2491 phosphate acyltransferase YP_002342277.1 821220 R 122587 CDS YP_002342278.1 218767766 906830 complement(822907..823965) 1 NC_003116.1 NMA0842, fbpC, probable iron-uptake permease ATP-binding protein, len: 352 aa; similar to many ABC-transporter ATP-binding proteins involved in iron uptake e.g. TR:Q50966 (EMBL:U33937), fpbC, Neisseria gonorrhoeae iron-regulated protein (352 aa), fasta scores; E(): 0, 93.5% identity in 352 aa overlap and SW:SFUC_SERMA (EMBL:M33815), sfuC, Serratia marcescens iron(III)-transport ATP-binding protein (345 aa), fasta scores; E(): 0, 41.8% identity in 352 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter,PS00211 ABC transporters family signature and two PS00017 ATP/GTP-binding site motif A (P-loop); iron-uptake permease ATP-binding protein 823965 906830 NMA0842 Neisseria meningitidis Z2491 iron-uptake permease ATP-binding protein YP_002342278.1 822907 R 122587 CDS YP_002342279.1 218767767 906831 complement(823986..825515) 1 NC_003116.1 NMA0843, fbpB, probable iron-uptake permease inner membrane protein, len: 509 aa; similar to many binding protein dependent permease components e.g. TR:Q50965 (EMBL:U33937), fbpB, Neisseria gonorrhoeae iron-regulated protein (511 aa), fasta scores; E(): 0, 89.8% identity in 512 aa overlap and SW:SFUB_SERMA (EMBL:M33815), sfuB,Serratia marcescens iron(III)-transport system permease (527 aa), fasta scores; E(): 0, 36.6% identity in 497 aa overlap. Contains two Pfam matches to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains hydrophobic, probable membrane-spanning regions; iron-uptake permease inner membrane protein 825515 906831 NMA0843 Neisseria meningitidis Z2491 iron-uptake permease inner membrane protein YP_002342279.1 823986 R 122587 CDS YP_002342280.1 218767768 906832 complement(825571..826566) 1 NC_003116.1 NMA0844, fbpA, major ferric iron binding protein,len: 331 aa; highly similar to many e.g. SW:FBP_NEIME (EMBL:X53467), fbpA, Neisseria meningitidis major ferric iron binding protein (330 aa), fasta scores; E(): 0, 98.8% identity in 331 aa overlap and probably constitutes the periplasmic binding component of an iron permease. Contains a probable N-terminal signal sequence; major ferric iron binding protein 826566 906832 NMA0844 Neisseria meningitidis Z2491 major ferric iron binding protein YP_002342280.1 825571 R 122587 CDS YP_002342281.1 218767769 906834 complement(join(826817..827062,827062..827286)) 1 NC_003116.1 NMA0846; unknown, fused with NMA0845 in MC58 and FAM18; hypothetical protein 827286 906834 NMA0846 Neisseria meningitidis Z2491 hypothetical protein YP_002342281.1 826817 R 122587 CDS YP_002342282.1 218767770 906835 complement(827343..828719) 1 NC_003116.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 828719 argH 906835 argH Neisseria meningitidis Z2491 argininosuccinate lyase YP_002342282.1 827343 R 122587 CDS YP_002342283.1 218767771 906836 complement(828738..829607) 1 NC_003116.1 NMA0848, galU, probable UTP--glucose-1-phosphate uridylyltransferase, len: 289 aa; similar to many e.g. SW:GALU_ECOLI (EMBL:X59940), galU, Escherichia coli UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (301 aa), fasta scores; E(): 0, 50.2% identity in 291 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase; UTP--glucose-1-phosphate uridylyltransferase 829607 906836 NMA0848 Neisseria meningitidis Z2491 UTP--glucose-1-phosphate uridylyltransferase YP_002342283.1 828738 R 122587 CDS YP_002342284.1 218767772 906837 complement(829635..830234) 1 NC_003116.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 830234 906837 NMA0849 Neisseria meningitidis Z2491 deoxyribonucleotide triphosphate pyrophosphatase YP_002342284.1 829635 R 122587 CDS YP_002342285.1 218767773 906838 complement(830227..830460) 1 NC_003116.1 NMA0850, len: 77 aa; unknown; hypothetical protein 830460 906838 NMA0850 Neisseria meningitidis Z2491 hypothetical protein YP_002342285.1 830227 R 122587 CDS YP_002342286.1 218767774 906839 complement(830568..831101) 1 NC_003116.1 NMA0851, ppa, probable inorganic pyrophosphatase,len: 177 aa; similar to many e.g. SW:IPYR_SULAC (EMBL:X81842), ppa, Sulfolobus acidocaldarius inorganic pyrophosphatase (EC 3.6.1.1) (173 aa), fasta scores; E(): 4.5e-20, 41.0% identity in 166 aa overlap. Contains Pfam match to entry PF00719 Pyrophosphatase, Inorganic pyrophosphatase and PS00387 Inorganic pyrophosphatase signature; inorganic pyrophosphatase 831101 906839 NMA0851 Neisseria meningitidis Z2491 inorganic pyrophosphatase YP_002342286.1 830568 R 122587 CDS YP_002342287.1 218767775 906840 complement(831203..831661) 1 NC_003116.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 831661 ntpA 906840 ntpA Neisseria meningitidis Z2491 dATP pyrophosphohydrolase YP_002342287.1 831203 R 122587 CDS YP_002342288.1 218767776 906841 832260..833930 1 NC_003116.1 NMA0853, mafB3, probable adhesin, len: 556 aa; similar, except at the C-terminus, to TR:AAD31039 (EMBL:AF142582), mafB, Neisseria gonorrhoeae adhesin (509 aa), E(): 9.1e-28, 32.0% identity in 425 aa overlap. Also similar to NMA2113, fasta scores; E(): 0, 38.6% identity in 412 aa overlap and NMA0324, fasta scores; (): 1.2e-27,33.5% identity in 376 aa overlap, differing from both at the C-terminus. Contains a probable N-terminal signal sequence; adhesin 833930 906841 NMA0853 Neisseria meningitidis Z2491 adhesin YP_002342288.1 832260 D 122587 CDS YP_002342289.1 218767777 906842 833927..834169 1 NC_003116.1 NMA0854, len: 80 aa; unknown, within a region of unusually low GC content; hypothetical protein 834169 906842 NMA0854 Neisseria meningitidis Z2491 hypothetical protein YP_002342289.1 833927 D 122587 CDS YP_002342290.1 218767778 906843 834247..834492 1 NC_003116.1 NMA0855, len: 81 aa; unknown, within a region of unusually low GC content; hypothetical protein 834492 906843 NMA0855 Neisseria meningitidis Z2491 hypothetical protein YP_002342290.1 834247 D 122587 CDS YP_002342291.1 218767779 906844 834495..834884 1 NC_003116.1 NMA0856, len: 129 aa; unknown, similar to NMA0857,fasta scores; E(): 2.7e-34, 62.8% identity in 129 aa overlap and NMA0858, fasta scores; E(): 0, 67.4% identity in 129 aa overlap. Within a region of unusually low GC content; hypothetical protein 834884 906844 NMA0856 Neisseria meningitidis Z2491 hypothetical protein YP_002342291.1 834495 D 122587 CDS YP_002342292.1 218767780 906845 835000..835449 1 NC_003116.1 NMA0857, len: 149 aa; unknown, similar to NMA0856,fasta scores; E(): 8e-34, 62.8% identity in 129 aa overlap and NMA0858, fasta scores; E(): 9.9e-32, 61.2% identity in 129 aa overlap. Within a region of unusually low GC content; hypothetical protein 835449 906845 NMA0857 Neisseria meningitidis Z2491 hypothetical protein YP_002342292.1 835000 D 122587 CDS YP_002342293.1 218767781 906846 835597..835986 1 NC_003116.1 NMA0858, len: 129 aa; unknown, similar to NMA0856,fasta scores; E(): 0, 67.4% identity in 129 aa overlap and NMA0857, fasta scores; E(): 1.7e-31, 61.2% identity in 129 aa overlap. Within a region of unusually low GC content; hypothetical protein 835986 906846 NMA0858 Neisseria meningitidis Z2491 hypothetical protein YP_002342293.1 835597 D 122587 CDS YP_002342294.1 218767782 906847 complement(836027..837484) 1 NC_003116.1 NMA0859, probable transmembrane potassium transporter, len: 485 aa; similar to many e.g. SW:TRKH_ECOLI (EMBL:M87049), trkH, Escherichia coli TRK system potassium uptake protein (483 aa), fasta scores; E(): 0, 41.8% identity in 486 aa overlap. Contains hydrophobic, probable membrane-spanning regions; transmembrane potassium transporter 837484 906847 NMA0859 Neisseria meningitidis Z2491 transmembrane potassium transporter YP_002342294.1 836027 R 122587 CDS YP_002342295.1 218767783 906848 complement(837499..838329) 1 NC_003116.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 838329 apaH 906848 apaH Neisseria meningitidis Z2491 diadenosine tetraphosphatase YP_002342295.1 837499 R 122587 CDS YP_002342296.1 218767784 906849 complement(838407..838796) 1 NC_003116.1 NMA0861, len: 129 aa; unknown, similar to many hypothetical proteins e.g. SW:YVN1_AZOVI (EMBL:M26752) Azotobacter vinelandii hypothetical protein (127 aa),fasta scores; E(): 2e-29, 66.9% identity in 127 aa overlap. Contains Pfam match to entry PF01042 DUF10,Domain of unknown function and PS01094 Hypothetical YER057c/yjjV family signature; hypothetical protein 838796 906849 NMA0861 Neisseria meningitidis Z2491 hypothetical protein YP_002342296.1 838407 R 122587 CDS YP_002342297.1 218767785 906850 complement(838932..839456) 1 NC_003116.1 NMA0862, nspA, outer membrane protein, len: 174 aa; highly similar to surface antigens from other Neisseria meningitidis isolates e.g. TR:P96943 (EMBL:U52066) Neisseria meningitidis strain 608B outer membrane protein precursor (174 aa), fasta scores; E(): 0, 98.3% identity in 174 aa overlap. Contains an N-terminal signal sequence. Similar to NMA1890, NMA2043 and NMA1676, which contain short indels with respect to nspA; outer membrane protein 839456 906850 NMA0862 Neisseria meningitidis Z2491 outer membrane protein YP_002342297.1 838932 R 122587 CDS YP_002342298.1 218767786 906851 complement(840042..841241) 1 NC_003116.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 841241 906851 NMA0864 Neisseria meningitidis Z2491 coproporphyrinogen III oxidase YP_002342298.1 840042 R 122587 CDS YP_002342299.1 218767787 906852 complement(841274..843799) 1 NC_003116.1 NMA0865, ligA, probable DNA ligase, len: 841 aa; similar to many e.g. SW:DNLJ_RHOMR (EMBL:U10483), ligA,Rhodothermus marinus DNA ligase (EC 6.5.1.2) (712 aa),fasta scores; E(): 0, 40.2% identity in 826 aa overlap. Contains Pfam matches to entry PF01653 DNA_ligase_N,NAD-dependent DNA ligase and to entry PF00533 BRCT, BRCA1 C Terminus (BRCT) domain. Contains PS01056 NAD-dependent DNA ligase signature 2 and PS00017 ATP/GTP-binding site motif A (P-loop); DNA ligase 843799 906852 NMA0865 Neisseria meningitidis Z2491 DNA ligase YP_002342299.1 841274 R 122587 CDS YP_002342300.1 218767788 906853 complement(843947..845233) 1 NC_003116.1 NMA0866, len: 428 aa; unknown, N-terminus is hydrophobic, contains a PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 845233 906853 NMA0866 Neisseria meningitidis Z2491 hypothetical protein YP_002342300.1 843947 R 122587 CDS YP_002342301.1 218767789 906854 complement(845427..845999) 1 NC_003116.1 NMA0867, ampD, probable anhydro-N-acetylmuramyl-tripeptide amidase, len: 190 aa; similar to many e.g. TR:Q46960 (EMBL:U40806), ampD,Enterobacter cloacae anhydro-N-acetylmuramyl-tripeptide amidase (187 aa), fasta scores; E(): 0, 52.9% identity in 172 aa overlap; N-acetyl-anhydromuranmyl-L-alanine amidase 845999 ampD 906854 ampD Neisseria meningitidis Z2491 N-acetyl-anhydromuranmyl-L-alanine amidase YP_002342301.1 845427 R 122587 CDS YP_002342302.1 218767790 906855 846083..847078 1 NC_003116.1 NMA0868, periplasmic protein, len: 331 aa; unknown, similar to many hypothetical proteins e.g. SW:YCEG_HAEIN (EMBL:U32728) Haemophilus influenzae hypothetical protein (347 aa), fasta scores; E(): 0, 44.2% identity in 260 aa overlap. Contains N-terminal signal sequence; hypothetical protein 847078 906855 NMA0868 Neisseria meningitidis Z2491 hypothetical protein YP_002342302.1 846083 D 122587 CDS YP_002342303.1 218767791 906856 847138..847758 1 NC_003116.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 847758 tmk 906856 tmk Neisseria meningitidis Z2491 thymidylate kinase YP_002342303.1 847138 D 122587 CDS YP_002342304.1 218767792 906857 847980..849260 1 NC_003116.1 NMA0870, maeA, probable malate oxidoreductase, len: 426 aa; similar to many e.g. SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus malate oxidoreductase (EC 1.1.1.38) (478 aa), fasta scores; E(): 0, 46.8% identity in 410 aa overlap. Contains PS00331 Malic enzymes signature; malate oxidoreductase 849260 906857 NMA0870 Neisseria meningitidis Z2491 malate oxidoreductase YP_002342304.1 847980 D 122587 CDS YP_002342305.1 218767793 906859 849807..850841 1 NC_003116.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 850841 lpxK 906859 lpxK Neisseria meningitidis Z2491 tetraacyldisaccharide 4'-kinase YP_002342305.1 849807 D 122587 CDS YP_002342306.1 218767794 906860 851041..851628 1 NC_003116.1 NMA0873, periplasmic protein, len: 195 aa; unknown, contains probable N-terminal signal sequence; hypothetical protein 851628 906860 NMA0873 Neisseria meningitidis Z2491 hypothetical protein YP_002342306.1 851041 D 122587 CDS YP_002342307.1 218767795 906861 851697..851879 1 NC_003116.1 NMA0874, len: 60 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:BAA35663 (EMBL:D90730) Escherichia coli hypothetical protein (60 aa), fasta scores; E(): 1.3e-10, 48.3% identity in 60 aa overlap; hypothetical protein 851879 906861 NMA0874 Neisseria meningitidis Z2491 hypothetical protein YP_002342307.1 851697 D 122587 CDS YP_002342308.1 218767796 906862 851876..852637 1 NC_003116.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 852637 kdsB 906862 kdsB Neisseria meningitidis Z2491 3-deoxy-manno-octulosonate cytidylyltransferase YP_002342308.1 851876 D 122587 CDS YP_002342309.1 218767797 906863 852660..853061 1 NC_003116.1 NMA0876, len: 133 aa; unknown, C-terminus contains a Neisseria meningitidis repeat, suggesting that the original C-terminus may have been removed by a recombination event; hypothetical protein 853061 906863 NMA0876 Neisseria meningitidis Z2491 hypothetical protein YP_002342309.1 852660 D 122587 CDS YP_002342310.1 218767798 906864 853115..853279 1 NC_003116.1 NMA0877, len: 54 aa; unknown; hypothetical protein 853279 906864 NMA0877 Neisseria meningitidis Z2491 hypothetical protein YP_002342310.1 853115 D 122587 CDS YP_002342311.1 218767799 906865 853257..853373 1 NC_003116.1 NMA0878, len: 38 aa; unknown; hypothetical protein 853373 906865 NMA0878 Neisseria meningitidis Z2491 hypothetical protein YP_002342311.1 853257 D 122587 CDS YP_002342312.1 218767800 906866 853953..854738 1 NC_003116.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 854738 trpA 906866 trpA Neisseria meningitidis Z2491 tryptophan synthase subunit alpha YP_002342312.1 853953 D 122587 CDS YP_002342313.1 218767801 906867 854775..855647 1 NC_003116.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 855647 accD 906867 accD Neisseria meningitidis Z2491 acetyl-CoA carboxylase subunit beta YP_002342313.1 854775 D 122587 CDS YP_002342314.1 218767802 906868 complement(855707..856318) 1 NC_003116.1 NMA0881, cnp1, periplasmic protein, len: 203 aa; highly similar to TR:Q50984 (EMBL:M84111), cnp1,Neisseria gonorrhoeae cryptic protein precursor (203 aa),fasta scores; E(): 0, 92.1% identity in 203 aa overlap. Reported to be found in pathogenic Neisseria gonorrhoeae and Neisseria meningitidis species, but not in commensal species. Contains probable N-terminal signal sequence; hypothetical protein 856318 906868 NMA0881 Neisseria meningitidis Z2491 hypothetical protein YP_002342314.1 855707 R 122587 CDS YP_002342315.1 218767803 906869 856427..856651 1 NC_003116.1 NMA0882, len: 74 aa; unknown, similar to hypothetical proteins e.g. SW:YRKI_BACSU (EMBL:D84432) Bacillus subtilis hypothetical protein (75 aa), fasta scores; E(): 6.6e-09, 38.0% identity in 71 aa overlap. Contains Pfam match to entry PF01206 UPF0033,Uncharacterized protein family UPF0033 and PS01148 Uncharacterized protein family UPF0033 signature; hypothetical protein 856651 906869 NMA0882 Neisseria meningitidis Z2491 hypothetical protein YP_002342315.1 856427 D 122587 CDS YP_002342316.1 218767804 906870 856664..857257 1 NC_003116.1 NMA0883, lipoprotein, len: 197 aa; unknown, contains probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 857257 906870 NMA0883 Neisseria meningitidis Z2491 lipoprotein YP_002342316.1 856664 D 122587 CDS YP_002342317.1 218767805 906871 857317..858351 1 NC_003116.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 858351 pyrC 906871 pyrC Neisseria meningitidis Z2491 dihydroorotase YP_002342317.1 857317 D 122587 CDS YP_002342318.1 218767806 906872 complement(858717..859142) 1 NC_003116.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 859142 nusB 906872 nusB Neisseria meningitidis Z2491 transcription antitermination protein NusB YP_002342318.1 858717 R 122587 CDS YP_002342319.1 218767807 906873 complement(859220..859696) 1 NC_003116.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 859696 ribH 906873 ribH Neisseria meningitidis Z2491 6,7-dimethyl-8-ribityllumazine synthase YP_002342319.1 859220 R 122587 CDS YP_002342320.1 218767808 906874 complement(859743..860066) 1 NC_003116.1 NMA0887, len: 107 aa; unknown; hypothetical protein 860066 906874 NMA0887 Neisseria meningitidis Z2491 hypothetical protein YP_002342320.1 859743 R 122587 CDS YP_002342321.1 218767809 906875 860233..860952 1 NC_003116.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 860952 rnc 906875 rnc Neisseria meningitidis Z2491 ribonuclease III YP_002342321.1 860233 D 122587 CDS YP_002342322.1 218767810 906876 860999..861922 1 NC_003116.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 861922 era 906876 era Neisseria meningitidis Z2491 GTP-binding protein Era YP_002342322.1 860999 D 122587 CDS YP_002342323.1 218767811 906877 complement(863413..864039) 1 NC_003116.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 864039 trpF 906877 trpF Neisseria meningitidis Z2491 N-(5'-phosphoribosyl)anthranilate isomerase YP_002342323.1 863413 R 122587 CDS YP_002342324.1 218767812 906878 complement(864098..864589) 1 NC_003116.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 864589 greB 906878 greB Neisseria meningitidis Z2491 transcription elongation factor GreB YP_002342324.1 864098 R 122587 CDS YP_002342325.1 218767813 906879 complement(864689..866233) 1 NC_003116.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 866233 purF 906879 purF Neisseria meningitidis Z2491 amidophosphoribosyltransferase YP_002342325.1 864689 R 122587 CDS YP_002342326.1 218767814 906880 complement(866442..866939) 1 NC_003116.1 NMA0894, membrane protein, len: 165 aa; similar to SW:CVPA_ECOL (EMBL:J01666), cvpA, Escherichia coli colicin V production protein (162 aa), fasta scores; E(): 4.7e-10, 31.2% identity in 138 aa overlap. Contains hydrophobic, membrane-spanning regions; hypothetical protein 866939 906880 NMA0894 Neisseria meningitidis Z2491 hypothetical protein YP_002342326.1 866442 R 122587 CDS YP_002342327.1 218767815 906881 complement(866932..867930) 1 NC_003116.1 NMA0895, tpc, tetrapac protein homologue, len: 332 aa; highly similar to TR:Q50991 (EMBL:Z68205), tpc,Neisseria gonorrhoeae tetrapac forming protein involved in natural transformation competence, epithelial cell invasion and cell separation (346 aa), fasta scores; E(): 0, 89.9% identity in 346 aa overlap. Contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; tetrapac protein 867930 906881 NMA0895 Neisseria meningitidis Z2491 tetrapac protein YP_002342327.1 866932 R 122587 CDS YP_002342328.1 218767816 906882 complement(867943..869217) 1 NC_003116.1 NMA0896, folC, bifunctional folylpolyglutamate synthase/dihydrofolate synthase, len: 424 aa; highly similar to many e.g. TR:Q50990 (EMBL:Z68205), folC,Neisseria gonorrhoeae bifunctional folylpolyglutamate synthase/dihydrofolate synthase (EC 6.3.2.17) (EC 6.3.2.12) (424 aa), fasta scores; E(): 0, 93.4% identity in 424 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family; bifunctional folylpolyglutamate synthase/dihydrofolate synthase 869217 906882 NMA0896 Neisseria meningitidis Z2491 bifunctional folylpolyglutamate synthase/dihydrofolate synthase YP_002342328.1 867943 R 122587 CDS YP_002342329.1 218767817 906883 complement(869249..869689) 1 NC_003116.1 NMA0897, folI, transcriptional regulator,len: 146 aa; highly similar to TR:Q50989 (EMBL:Z68205),folI, Neisseria gonorrhoeae transcriptional activator (146 aa), fasta scores; E(): 0, 95.8% identity in 144 aa overlap. Note that activation of folC expression by folI provided in trans has only been demonstrated in Escherichia coli; transcriptional regulator 869689 906883 NMA0897 Neisseria meningitidis Z2491 transcriptional regulator YP_002342329.1 869249 R 122587 CDS YP_002342330.1 218767818 906884 complement(869694..870068) 1 NC_003116.1 NMA0899, len: 124 aa; unknown; hypothetical protein 870068 906884 NMA0899 Neisseria meningitidis Z2491 hypothetical protein YP_002342330.1 869694 R 122587 CDS YP_002342331.1 218767819 906885 complement(870126..870854) 1 NC_003116.1 NMA0900, amino acid permease ATP-binding protein, len: 242 aa; similar to many e.g. SW:GLNQ_BACST (EMBL:M61017), glnQ, Bacillus stearothermophilus glutamine transport ATP-binding protein (242 aa), fasta scores; E(): 0, 63.2% identity in 242 aa overlap and SW:AAPP_RHILV (EMBL:X82596), aapP, Rhizobium leguminosarum general L-amino acid transport ATP-binding protein (257 aa), fasta scores; E(): 0, 56.9% identity in 239 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter,PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); amino acid permease ATP-binding protein 870854 906885 NMA0900 Neisseria meningitidis Z2491 amino acid permease ATP-binding protein YP_002342331.1 870126 R 122587 CDS YP_002342332.1 218767820 906886 complement(871027..871806) 1 NC_003116.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 871806 ksgA 906886 ksgA Neisseria meningitidis Z2491 dimethyladenosine transferase YP_002342332.1 871027 R 122587 CDS YP_002342333.1 218767821 906887 871997..872692 1 NC_003116.1 NMA0903, len: 231 aa; unknown; hypothetical protein 872692 906887 NMA0903 Neisseria meningitidis Z2491 hypothetical protein YP_002342333.1 871997 D 122587 CDS YP_002342334.1 218767822 906888 872877..874079 1 NC_003116.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 874079 trpB 906888 trpB Neisseria meningitidis Z2491 tryptophan synthase subunit beta YP_002342334.1 872877 D 122587 CDS YP_002342335.1 218767823 906889 complement(874258..879579) 1 NC_003116.1 NMA0905, iga, IgA1 protease, len: 1773 aa; highly similar to IgA1 proteases from Neisseria and Haemophilus species e.g. TR:Q51169 (EMBL:X82474), iga, Neisseria meningitidis HF13 IgA1 protease (1561 aa), fasta scores; E(): 0, 77.9% identity in 1784 aa overlap. Also similar to NMA0457, iga2 (29.9% identity in 1339 aa overlap); IgA1 protease 879579 906889 NMA0905 Neisseria meningitidis Z2491 IgA1 protease YP_002342335.1 874258 R 122587 CDS YP_002342336.1 218767824 906890 881651..883726 1 NC_003116.1 NMA0906, comA, competence protein, len: 691 aa; highly similar to SW:COMA_NEIGO (EMBL:S75490), comA,Neisseria gonorrhoeae competence protein essential for natural transformation (691 aa), fasta scores; E(): 0,95.1% identity in 691 aa overlap. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily. Contains hydrophobic, probable membrane-spanning regions; competence protein 883726 906890 NMA0906 Neisseria meningitidis Z2491 competence protein YP_002342336.1 881651 D 122587 CDS YP_002342337.1 218767825 906891 complement(883784..884587) 1 NC_003116.1 NMA0907, comL, competence lipoprotein, len: 267 aa; highly similar to SW:COML_NEIGO (EMBL:Z49895), comL,Neisseria gonorrhoeae competence lipoprotein (267 aa),fasta scores; E(): 0, 98.5% identity in 267 aa overlap. Contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a probable N-terminal signal sequence; competence lipoprotein 884587 906891 NMA0907 Neisseria meningitidis Z2491 competence lipoprotein YP_002342337.1 883784 R 122587 CDS YP_002342338.1 218767826 906892 884586..885710 1 NC_003116.1 NMA0908, rluD, probable ribosomal large subunit pseudouridine synthase D, len: 374 aa; similar to many e.g. SW:RLUD_ECOLI (EMBL:U50134), rluD, Escherichia coli ribosomal large subunit pseudouridine synthase D (EC 4.2.1.70) (326 aa), fasta scores; E(): 0, 49.5% identity in 323 aa overlap. This protein has an N-terminal extension of approx. 20 aa which is not present in otherwise similar proteins. Contains Pfam matches to entry PF01479 S4, S4 domain and to entry PF00849 YABO,Hypothetical yabO/yceC/sfhB family. Contains PS01129 Hypothetical yabO/yceC/sfhB family signature; ribosomal large subunit pseudouridine synthase D 885710 906892 NMA0908 Neisseria meningitidis Z2491 ribosomal large subunit pseudouridine synthase D YP_002342338.1 884586 D 122587 CDS YP_002342339.1 218767827 906893 complement(885863..886810) 1 NC_003116.1 NMA0909, probable transmembrane transport protein,len: 315 aa; similar to many eukaryotic (Na)+ dependent transporters e.g. SW:NTCI_HUMAN (EMBL:U10417), SLC10A2,Homo sapiens ileal sodium/bile acid cotransporter (348 aa), fasta scores; E(): 9.9e-19, 31.4% identity in 287 aa overlap. Also similar to bacterial hypothetical proteins e.g. TR:O34524 (EMBL:AF027868), yocS, Bacillus subtilis transporter (321 aa), fasta scores; E(): 0, 58.1% identity in 313 aa overlap. Similar to NMA0046, fasta scores; E(): 0, 37.4% identity in 310 aa overlap. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein 886810 906893 NMA0909 Neisseria meningitidis Z2491 transmembrane transport protein YP_002342339.1 885863 R 122587 CDS YP_002342340.1 218767828 906894 887369..888148 1 NC_003116.1 NMA0911, len: 259 aa; unknown, similar to many bacterial hypothetical proteins e.g. SW:YFIH_ECOLI (EMBL:U50134), yfiH, Escherichia coli hypothetical protein (243 aa), fasta scores; E(): 0, 50.4% identity in 240 aa overlap; hypothetical protein 888148 906894 NMA0911 Neisseria meningitidis Z2491 hypothetical protein YP_002342340.1 887369 D 122587 CDS YP_002342341.1 218767829 906895 888200..888679 1 NC_003116.1 NMA0912, probable lipoprotein, len; 159 aa; similar to SW:RLPB_ECOLI (EMBL:M18277), rlpB, Escherichia coli rare lipoprotein B precursor (193 aa), fasta scores; E(): 1.9e-07, 30.3% identity in 165 aa overlap. Contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a probable N-terminal signal sequence; lipoprotein 888679 906895 NMA0912 Neisseria meningitidis Z2491 lipoprotein YP_002342341.1 888200 D 122587 CDS YP_002342342.1 218767830 906896 888681..889679 1 NC_003116.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 889679 holA 906896 holA Neisseria meningitidis Z2491 DNA polymerase III subunit delta YP_002342342.1 888681 D 122587 CDS YP_002342343.1 218767831 906897 889800..890219 1 NC_003116.1 NMA0914, membrane protein, len: 139 aa; unknown, contains hydrophobic, membrane-spanning regions; hypothetical protein 890219 906897 NMA0914 Neisseria meningitidis Z2491 hypothetical protein YP_002342343.1 889800 D 122587 CDS YP_002342344.1 218767832 906898 890297..890809 1 NC_003116.1 NMA0915, len: 170 aa; unknown, contains hydrophobic, membrane-spanning regions; hypothetical protein 890809 906898 NMA0915 Neisseria meningitidis Z2491 hypothetical protein YP_002342344.1 890297 D 122587 CDS YP_002342345.1 218767833 906899 complement(890893..891777) 1 NC_003116.1 NMA0916, len: 294 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YICC_ECOLI (EMBL:L10328),yicC, Escherichia coli hypothetical protein (287 aa),fasta scores; E(): 0, 41.0% identity in 290 aa overlap; hypothetical protein 891777 906899 NMA0916 Neisseria meningitidis Z2491 hypothetical protein YP_002342345.1 890893 R 122587 CDS YP_002342346.1 218767834 906900 complement(892264..893136) 1 NC_003116.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 893136 rpoH 906900 rpoH Neisseria meningitidis Z2491 RNA polymerase factor sigma-32 YP_002342346.1 892264 R 122587 CDS YP_002342347.1 218767835 906901 complement(893391..894929) 1 NC_003116.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 894929 lnt 906901 lnt Neisseria meningitidis Z2491 apolipoprotein N-acyltransferase YP_002342347.1 893391 R 122587 CDS YP_002342348.1 218767836 906902 complement(894969..895724) 1 NC_003116.1 NMA0919, similar to hypothetical proteins from Escherichia coli and Mycobacterium tuberculosis e.g. SW:YEDI_ECOLI (EMBL:AE000287), yedI, Escherichia coli hypothetical protein (305 aa), fasta scores; E(): 7.7e-24,60.5% identity in 114 aa overlap; hypothetical protein 895724 906902 NMA0919 Neisseria meningitidis Z2491 hypothetical protein YP_002342348.1 894969 R 122587 CDS YP_002342349.1 218767837 906903 895920..896201 1 NC_003116.1 NMA0921, similar to hypothetical proteins from Escherichia coli e.g. SW:YCGO_ECOLI (EMBL:AE000217), ycgO,Escherichia coli Na(+)/H(+) exchanger (578 aa),blastp score; Expect = 2.3e-11; hypothetical protein 896201 906903 NMA0921 Neisseria meningitidis Z2491 hypothetical protein YP_002342349.1 895920 D 122587 CDS YP_002342350.1 218767838 7163864 896747..897037 1 NC_003116.1 hypothetical protein 897037 7163864 NMA0924 Neisseria meningitidis Z2491 hypothetical protein YP_002342350.1 896747 D 122587 CDS YP_002342351.1 218767839 906904 complement(897012..897503) 1 NC_003116.1 NMA0925, cytochrome C, len: 163 aa; shows very weak similarity to many e.g. SW:C552_THETH (EMBL:M93437), cycA, Thermus aquaticus cytochrome C-552 precursor (148 aa), fasta scores; E(): 0.00017, 33.6% identity in 137 aa overlap. Contains Pfam match to entry PF00034 cytochrome_c, Cytochrome c and PS00190 Cytochrome c family heme-binding site signature. Contains a probable N-terminal signal sequence; cytochrome C 897503 906904 NMA0925 Neisseria meningitidis Z2491 cytochrome C YP_002342351.1 897012 R 122587 CDS YP_002342352.1 218767840 906906 complement(897694..898704) 1 NC_003116.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 898704 hemH 906906 hemH Neisseria meningitidis Z2491 ferrochelatase YP_002342352.1 897694 R 122587 CDS YP_002342353.1 218767841 906907 complement(898786..899901) 1 NC_003116.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 899901 tgt 906907 tgt Neisseria meningitidis Z2491 queuine tRNA-ribosyltransferase YP_002342353.1 898786 R 122587 CDS YP_002342354.1 218767842 906908 900210..902123 1 NC_003116.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 902123 thrS 906908 thrS Neisseria meningitidis Z2491 threonyl-tRNA synthetase YP_002342354.1 900210 D 122587 CDS YP_002342355.1 218767843 906909 902141..902662 1 NC_003116.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 902662 infC 906909 infC Neisseria meningitidis Z2491 translation initiation factor IF-3 YP_002342355.1 902141 D 122587 CDS YP_002342356.1 218767844 906910 902809..903006 1 NC_003116.1 NMA0931, rpmI, probable 50S ribosomal protein L35,len: 65 aa; similar to many e.g. SW:RL35_ECOLI (EMBL:AE000266), rpmI, Escherichia coli 50S ribosomal protein L35 (64 aa), fasta scores; E(): 2.4e-10, 57.8% identity in 64 aa overlap. Contains Pfam match to entry PF01632 Ribosomal_L35p, Ribosomal protein L35 and PS00936 Ribosomal protein L35 signature; 50S ribosomal protein L35 903006 rpmI 906910 rpmI Neisseria meningitidis Z2491 50S ribosomal protein L35 YP_002342356.1 902809 D 122587 CDS YP_002342357.1 218767845 906911 903019..903378 1 NC_003116.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 903378 rplT 906911 rplT Neisseria meningitidis Z2491 50S ribosomal protein L20 YP_002342357.1 903019 D 122587 CDS YP_002342358.1 218767846 906912 903724..904716 1 NC_003116.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 904716 pheS 906912 pheS Neisseria meningitidis Z2491 phenylalanyl-tRNA synthetase subunit alpha YP_002342358.1 903724 D 122587 CDS YP_002342359.1 218767847 906913 904893..905957 1 NC_003116.1 NMA0935, len: 354 aa; unknown, lies in a region of unusually low GC content. Similar to NMA0346, fasta scores; E(): 8.4e-19, 28.9% identity in 339 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 905957 906913 NMA0935 Neisseria meningitidis Z2491 hypothetical protein YP_002342359.1 904893 D 122587 CDS YP_002342360.1 218767848 906914 905964..906482 1 NC_003116.1 NMA0936, len: 172 aa; unknown, lies in a region of unusually low GC content; hypothetical protein 906482 906914 NMA0936 Neisseria meningitidis Z2491 hypothetical protein YP_002342360.1 905964 D 122587 CDS YP_002342361.1 218767849 906915 906518..908881 1 NC_003116.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 908881 pheT 906915 pheT Neisseria meningitidis Z2491 phenylalanyl-tRNA synthetase subunit beta YP_002342361.1 906518 D 122587 CDS YP_002342362.1 218767850 906916 908955..909257 1 NC_003116.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 909257 ihfA 906916 ihfA Neisseria meningitidis Z2491 integration host factor subunit alpha YP_002342362.1 908955 D 122587 CDS YP_002342363.1 218767851 906917 909259..909549 1 NC_003116.1 NMA0939, len: 96 aa; unknown; hypothetical protein 909549 906917 NMA0939 Neisseria meningitidis Z2491 hypothetical protein YP_002342363.1 909259 D 122587 CDS YP_002342364.1 218767852 906918 909879..910364 1 NC_003116.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 910364 fxsA 906918 fxsA Neisseria meningitidis Z2491 FxsA protein YP_002342364.1 909879 D 122587 CDS YP_002342365.1 218767853 906919 910624..910863 1 NC_003116.1 NMA0941, len: 79 aa; unknown; hypothetical protein 910863 906919 NMA0941 Neisseria meningitidis Z2491 hypothetical protein YP_002342365.1 910624 D 122587 CDS YP_002342366.1 218767854 906920 911076..912377 1 NC_003116.1 NMA0942, bioA, probable adenosylmethionine-8-amino-7-oxononanoate aminotransferase, len: 433 aa; similar to many e.g. SW:BIOA_ECOLI (EMBL:J04423), bioA, Escherichia coli adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (429 aa), fasta scores; E(): 0, 58.4% identity in 418 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 912377 906920 NMA0942 Neisseria meningitidis Z2491 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_002342366.1 911076 D 122587 CDS YP_002342367.1 218767855 906921 912374..913021 1 NC_003116.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 913021 bioD 906921 bioD Neisseria meningitidis Z2491 dithiobiotin synthetase YP_002342367.1 912374 D 122587 CDS YP_002342368.1 218767856 906922 913036..913512 1 NC_003116.1 NMA0944, len: 158 aa, unknown, shows very weak similarity in the C-terminus to SW:UBIC_ECOLI (EMBL:M93136), ubiC, Escherichia coli chorismate--pyruvate lyase (EC 4.-.-.-) (164 aa), fasta scores; E(): 0.0086,34.1% identity in 91 aa overlap; hypothetical protein 913512 906922 NMA0944 Neisseria meningitidis Z2491 hypothetical protein YP_002342368.1 913036 D 122587 CDS YP_002342369.1 218767857 906923 913542..914432 1 NC_003116.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 914432 ubiA 906923 ubiA Neisseria meningitidis Z2491 4-hydroxybenzoate octaprenyltransferase YP_002342369.1 913542 D 122587 CDS YP_002342370.1 218767858 906924 914617..915066 1 NC_003116.1 NMA0946, regulatory protein, len: 149 aa; similar to CDS from several rpoN operons e.g. SW:PTSN_ECOLI (EMBL:U12684), ptsN, Escherichia coli nitrogen regulatory IIA protein (EC 2.7.1.69) (163 aa),fasta scores; E(): 9.4e-17, 42.6% identity in 129 aa overlap, which influences transcription of sigma 54-dependent genes. Contains Pfam match to entry PF00359 PTS_EIIA_2, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 and PS00372 PTS EIIA domains phosphorylation site signature 2; regulatory protein 915066 906924 NMA0946 Neisseria meningitidis Z2491 regulatory protein YP_002342370.1 914617 D 122587 CDS YP_002342371.1 218767859 906925 915070..916032 1 NC_003116.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 916032 906925 NMA0947 Neisseria meningitidis Z2491 HPr kinase/phosphorylase YP_002342371.1 915070 D 122587 CDS YP_002342372.1 218767860 906926 916013..916867 1 NC_003116.1 NMA0948, len: 284 aa; similar to many e.g. TR:Q9ZA87 (EMBL:AF088980) Proteus mirabilis protein (284 aa), fasta scores; E(): 0, 44.0% identity in 282 aa overlap. Proteus mirabilis mutated in this gene exhibit reduced virulence in a mouse model of ascending urinary tract infection. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 916867 906926 NMA0948 Neisseria meningitidis Z2491 hypothetical protein YP_002342372.1 916013 D 122587 CDS YP_002342373.1 218767861 906927 916948..917889 1 NC_003116.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 917889 rbgA 906927 rbgA Neisseria meningitidis Z2491 ribosomal biogenesis GTPase YP_002342373.1 916948 D 122587 CDS YP_002342374.1 218767862 906928 917990..918592 1 NC_003116.1 NMA0951, len: 200 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:O83471 (EMBL:AE001223),TP0458, Treponema pallidum hypothetical protein (192 aa),fasta scores; E(): 4.9e-12, 38.2% identity in 173 aa overlap; hypothetical protein 918592 906928 NMA0951 Neisseria meningitidis Z2491 hypothetical protein YP_002342374.1 917990 D 122587 CDS YP_002342375.1 218767863 906929 918776..920449 1 NC_003116.1 NMA0952, recN, probable DNA repair protein, len: 557 aa; similar to many e.g. SW:RECN_ECOLI (EMBL:Y00357),recN, Escherichia coli DNA repair protein (553 aa), fasta scores; E():0, 39.1% identity in 553 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); DNA repair protein 920449 906929 NMA0952 Neisseria meningitidis Z2491 DNA repair protein YP_002342375.1 918776 D 122587 CDS YP_002342376.1 218767864 906931 complement(921567..923186) 1 NC_003116.1 NMA0954, len: 539 aa; unknown, similar to parts of bacterial hypothetical proteins e.g. TR:P77182 (EMBL:AE000321) Escherichia coli hypothetical protein (688 aa), fasta scores; E(): 1.7e-28, 26.8% identity in 477 aa overlap; hypothetical protein 923186 906931 NMA0954 Neisseria meningitidis Z2491 hypothetical protein YP_002342376.1 921567 R 122587 CDS YP_002342377.1 218767865 906932 923282..923674 1 NC_003116.1 NMA0955, len: 130 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:Q51512 (EMBL:X66592) Pseudomonas aeruginosa hypothetical protein (123 aa),fasta scores; E(): 5.6e-22, 56.3% identity in 112 aa overlap; hypothetical protein 923674 906932 NMA0955 Neisseria meningitidis Z2491 hypothetical protein YP_002342377.1 923282 D 122587 CDS YP_002342378.1 218767866 906933 923717..924454 1 NC_003116.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 924454 ubiE 906933 ubiE Neisseria meningitidis Z2491 ubiquinone/menaquinone biosynthesis methyltransferase YP_002342378.1 923717 D 122587 CDS YP_002342379.1 218767867 906934 924674..925153 1 NC_003116.1 NMA0957, len: 159 aa; unknown; hypothetical protein 925153 906934 NMA0957 Neisseria meningitidis Z2491 hypothetical protein YP_002342379.1 924674 D 122587 CDS YP_002342380.1 218767868 906935 complement(925280..925774) 1 NC_003116.1 NMA0958, folK, probable 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine- pyrophosphokinase, len: 164 aa; similar to many e.g. SW:HPPK_ECOLI (EMBL:L06495), folK, Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (158 aa), fasta scores; E(): 1.2e-15, 43.0% identity in 135 aa overlap. Contains fam match to entry PF01288 HPPK,7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase (HPPK); 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine- pyrophosphokinase 925774 906935 NMA0958 Neisseria meningitidis Z2491 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine- pyrophosphokinase YP_002342380.1 925280 R 122587 CDS YP_002342381.1 218767869 906936 complement(925784..926158) 1 NC_003116.1 NMA0959, regulator, len: 124 aa; similar to TR:AAD32201 (EMBL:AF134855), sirB ORF1, Salmonella typhimurium protein affecting expression of a type III secretion system within Salmonella pathogenicity island 1 (129 aa), fasta scores; E(): 3.3e-06, 31.9% identity in 119 aa overlap and TR:Q46755 (EMBL:U18555) Escherichia coli hypothetical protein within kdsA operon (130 aa),fasta scores; E(): 1.3e-06, 29.3% identity in 116 aa overlap; regulator 926158 906936 NMA0959 Neisseria meningitidis Z2491 regulator YP_002342381.1 925784 R 122587 CDS YP_002342382.1 218767870 906937 complement(926212..926778) 1 NC_003116.1 NMA0960, len: 188 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:O34614 (EMBL:AF008220),ytqB, Bacillus subtilis hypothetical protein (194 aa),fasta scores; E(): 3.1e-28, 41.4% identity in 191 aa overlap; hypothetical protein 926778 906937 NMA0960 Neisseria meningitidis Z2491 hypothetical protein YP_002342382.1 926212 R 122587 CDS YP_002342383.1 218767871 906938 complement(926863..927156) 1 NC_003116.1 NMA0961, hfq, probable regulator, len: 97 aa; similar to many e.g. TR:Q56928 (EMBL:D28762), ymr,Yersinia enterocolitica positive regulator of expression of heat-stable enterotoxin gene (101 aa), fasta scores; E(): 3.3e-20, 65.6% identity in 96 aa overlap, TR:AAD38187 (EMBL:AF154075), hfq, Brucella abortus host factor I protein which is a major determinant of virulence in mice (78 aa), fasta scores; E(): 2.4e-11, 51.4% identity in 72 aa overlap and SW:HFQ_ECOLI (EMBL:D00743), hfq,Escherichia coli host factor-I protein for bacteriophage Q beta (101 aa), fasta scores; E(): 1e-19, 63.0% identity in 100 aa overlap; regulator 927156 906938 NMA0961 Neisseria meningitidis Z2491 regulator YP_002342383.1 926863 R 122587 CDS YP_002342384.1 218767872 906939 complement(927285..928223) 1 NC_003116.1 NMA0962, probable D-alanyl-D-alanine-endopeptidase,len: 312 aa; similar to many penicillin-binding proteins e.g. TR:AF156692 (EMBL:AF156692), pbp4, Neisseria gonorrhoeae penicillin-binding protein 4 (312 aa), fasta scores; E(): 0, 98.1% identity in 312 aa overlap and SW:PBP5_PSEAE (EMBL:U62582), pbpG, Pseudomonas aeruginosa penicillin-binding protein 5 precursor (EC 3.4.-.-) (311 aa), fasta scores; E(): 0, 43.8% identity in 240 aa overlap. Similar to part of NMA1095, fasta scores; E(): 1.2e-13, 29.6% identity in 243 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine-endopeptidase 928223 906939 NMA0962 Neisseria meningitidis Z2491 D-alanyl-D-alanine-endopeptidase YP_002342384.1 927285 R 122587 CDS YP_002342385.1 218767873 906940 928481..928984 1 NC_003116.1 NMA0963, len: 167 aa; unknown, similar to many bacterial proteins of unknown function e.g. TR:P72697 (EMBL:D90900), bcp, Synechocystis sp. bacterioferritin comigratory protein (160 aa), fasta scores; E(): 4.3e-22,45.1% identity in 142 aa overlap. Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family; hypothetical protein 928984 906940 NMA0963 Neisseria meningitidis Z2491 hypothetical protein YP_002342385.1 928481 D 122587 CDS YP_002342386.1 218767874 906941 929036..929911 1 NC_003116.1 NMA0964, xerD, probable integrase/recombinase, len: 291 aa; similar to many e.g. SW:XERD_ECOLI (EMBL:M54884),xerD, Escherichia coli integrase/recombinase (298 aa),fasta scores; E(): 0, 48.6% identity in 290 aa overlap. Contains Pfam match to entry PF00589 Phage_integrase,'Phage' integrase family. Similar to NMA0588, fasta scores; E(): 2.9e-30, 35.0% identity in 294 aa overlap; integrase/recombinase 929911 906941 NMA0964 Neisseria meningitidis Z2491 integrase/recombinase YP_002342386.1 929036 D 122587 CDS YP_002342387.1 218767875 906942 930083..930283 1 NC_003116.1 NMA0965, probable ferredoxin, len: 66 aa; similar to many e.g. SW:BFD_ECOLI (EMBL:M27176), bfd, Escherichia coli bacterioferritin-associated ferredoxin (64 aa), fasta scores; E(): 0.47, 28.6% identity in 42 aa overlap; ferredoxin 930283 906942 NMA0965 Neisseria meningitidis Z2491 ferredoxin YP_002342387.1 930083 D 122587 CDS YP_002342388.1 218767876 906943 930449..930682 1 NC_003116.1 NMA0966, thioredoxin, len: 77 aa; shows weak similarity to many e.g. TR:CAB40815 (EMBL:AJ133006),trxA, Listeria monocytogenes thioredoxin (EC 1.8.1.9) (103 aa), fasta scores; E(): 0.41, 33.8% identity in 65 aa overlap and SW:YV35_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis hypothetical protein (97 aa), fasta scores; E(): 4e-05, 29.8% identity in 84 aa overlap. Contains PS00190 Cytochrome c family heme-binding site signature; thioredoxin 930682 906943 NMA0966 Neisseria meningitidis Z2491 thioredoxin YP_002342388.1 930449 D 122587 CDS YP_002342389.1 218767877 906944 complement(931156..932019) 1 NC_003116.1 NMA0967, rfbD, probable dTDP-4-dehydrorhamnose reductase, len: 287 aa; similar to many e.g. SW:RFBD_SALTY (EMBL:X56793), rfbD, Salmonella typhimurium dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) (299 aa),fasta scores; E(): 0, 39.0% identity in 295 aa overlap; dTDP-4-dehydrorhamnose reductase 932019 906944 NMA0967 Neisseria meningitidis Z2491 dTDP-4-dehydrorhamnose reductase YP_002342389.1 931156 R 122587 CDS YP_002342390.1 218767878 906945 932217..933080 1 NC_003116.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 933080 hemH 906945 hemH Neisseria meningitidis Z2491 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002342390.1 932217 D 122587 CDS YP_002342391.1 218767879 906946 933317..935437 1 NC_003116.1 NMA0969, pnp, probable polyribonucleotide nucleotidyltransferase, len: 706 aa; similar to many e.g. SW:PNP_PHOLU (EMBL:X76069), pnp, Photorhabdus luminescens polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (709 aa), fasta scores; E(): 0, 63.7% identity in 703 aa overlap. Contains two Pfam matches to entry PF01138 RNase_PH, 3' exoribonuclease family, Pfam match to entry PF00013 KH-domain, KH domain and Pfam match to entry PF00575 S1, S1 RNA binding domain; polynucleotide phosphorylase 935437 pnp 906946 pnp Neisseria meningitidis Z2491 polynucleotide phosphorylase YP_002342391.1 933317 D 122587 CDS YP_002342392.1 218767880 906947 complement(935510..936178) 1 NC_003116.1 NMA0970, len: 222 aa; unknown; hypothetical protein 936178 906947 NMA0970 Neisseria meningitidis Z2491 hypothetical protein YP_002342392.1 935510 R 122587 CDS YP_002342393.1 218767881 906948 complement(936192..936488) 1 NC_003116.1 NMA0971, lipoprotein, len: 98 aa; unknown,contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 936488 906948 NMA0971 Neisseria meningitidis Z2491 lipoprotein YP_002342393.1 936192 R 122587 CDS YP_002342394.1 218767882 906949 936625..937476 1 NC_003116.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 937476 dapF 906949 dapF Neisseria meningitidis Z2491 diaminopimelate epimerase YP_002342394.1 936625 D 122587 CDS YP_002342395.1 218767883 906950 937473..938078 1 NC_003116.1 NMA0973, probable integral membrane protein, len: 201 aa; unknown. Contains hydrophobic, probable membrane-spanning regions; integral membrane protein 938078 906950 NMA0973 Neisseria meningitidis Z2491 integral membrane protein YP_002342395.1 937473 D 122587 CDS YP_002342396.1 218767884 906951 938272..939204 1 NC_003116.1 NMA0974, cysK, probable cysteine synthase, len: 310 aa; similar to many from bacteria and eukaryotes e.g. SW:CYSK_SPIOL (EMBL:D10476), cysK, Spinacia oleracea cysteine synthase (EC 2.5.1.47) (325 aa), fasta scores; E(): 0, 58.1% identity in 310 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase,Pyridoxal-phosphate dependent enzymes and PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site; cysteine synthase 939204 906951 NMA0974 Neisseria meningitidis Z2491 cysteine synthase YP_002342396.1 938272 D 122587 CDS YP_002342397.1 218767885 906952 939791..940669 1 NC_003116.1 NMA0975, probable integral membrane protein, len: 292 aa; unknown, shows weak similarity to bacterial hypothetical proteins e.g. SW:YDED_ECOLI (EMBL:AE000250),ydeD, Escherichia coli hypothetical protein (266 aa),fasta scores; E(): 1.4e-07, 27.8% identity in 255 aa overlap. Contains hydrophobic, probable membrane-spanning regions; integral membrane protein 940669 906952 NMA0975 Neisseria meningitidis Z2491 integral membrane protein YP_002342397.1 939791 D 122587 CDS YP_002342398.1 218767886 906953 complement(940934..941953) 1 NC_003116.1 NMA0976, lepB, probable signal peptidase I, len: 292 aa; similar to many e.g. SW:LEP_ECOLI (EMBL:K00426),lepB, Escherichia coli signal peptidase I (EC 3.4.21.89) (324 aa), fasta scores; E(): 1.5e-27, 40.9% identity in 257 aa overlap. The N-terminus differs from its homologues. A start codon chosen with reference to the N-terminal membrane-spanning regions found in characterised signal peptidases. Contains two Pfam match to entry PF00461 Peptidase_S26, Signal peptidase I,PS00760 Signal peptidases I lysine active site and PS00761 Signal peptidases I signature 3; signal peptidase I 941953 906953 NMA0976 Neisseria meningitidis Z2491 signal peptidase I YP_002342398.1 940934 R 122587 CDS YP_002342399.1 218767887 906954 complement(942096..943889) 1 NC_003116.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 943889 lepA 906954 lepA Neisseria meningitidis Z2491 GTP-binding protein LepA YP_002342399.1 942096 R 122587 CDS YP_002342400.1 218767888 906955 complement(944034..944735) 1 NC_003116.1 NMA0978, pfs, probable 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, len: 233 aa; similar to many e.g. SW:PFS_ECOLI (EMBL:U24438), pfs, Escherichia coli MTA/SAH nucleosidase (EC 3.2.2.16) (EC 3.2.2.9) (232 aa), fasta scores; E(): 0, 47.8% identity in 228 aa overlap. Contains Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase family; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 944735 906955 NMA0978 Neisseria meningitidis Z2491 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_002342400.1 944034 R 122587 CDS YP_002342401.1 218767889 906956 944921..946033 1 NC_003116.1 NMA0979, pilT2, pilus retraction protein,len: 370 aa; similar to many e.g. SW:PILT_PSEAE (EMBL:M55524), pilT, Pseudomonas aeruginosa twitching mobility protein which complements mutants deficient in this function (344 aa), fasta scores; E(): 0, 43.8% identity in 329 aa overlap. Similar to TR:O85741 (EMBL:AF074716), pilT, from Neisseria meningitidis (strain 8013) (347 aa), fasta scores; E(): 0, 40.9% identity in 335 aa overlap. Shows weaker similarity to bacterial type II secretion proteins e.g. SW:GSPE_KLEPN (EMBL:M32613),pulE, Klebsiella pneumoniae general secretion pathway protein (497 aa), fasta scores; E(): 5.6e-14, 33.1% identity in 281 aa overlap. Also similar to NMA0218, fasta scores; E(): 0, 40.1% identity in 334 aa overlap and NMA0219, fasta scores; E(): 0, 44.8% identity in 348 aa overlap. Contains Pfam match to entry PF00437 GSPII_E,Bacterial type II secretion system protein, PS00662 Bacterial type II secretion system protein E signature and PS00017 ATP/GTP-binding site motif A (P-loop). Also similar to pilT NMA0218 (40.1% identity in 334 aa overlap), and pilU NMA0219 (44.8% identity in 348 aa overlap); pilus retraction protein 946033 906956 NMA0979 Neisseria meningitidis Z2491 pilus retraction protein YP_002342401.1 944921 D 122587 CDS YP_002342402.1 218767890 906957 946067..947044 1 NC_003116.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 947044 holB 906957 holB Neisseria meningitidis Z2491 DNA polymerase III subunit delta' YP_002342402.1 946067 D 122587 CDS YP_002342403.1 218767891 906958 947048..947398 1 NC_003116.1 NMA0981, pilus biogenesis protein, len: 116 aa; similar to TR:Q51538 (EMBL:L42622), pilZ,Pseudomonas aeruginosa protein involved in biogenesis of type 4 fimbriae (118 aa), fasta scores; E(): 9.9e-12,31.5% identity in 108 aa overlap; pilus biogenesis protein 947398 906958 NMA0981 Neisseria meningitidis Z2491 pilus biogenesis protein YP_002342403.1 947048 D 122587 CDS YP_002342404.1 218767892 906959 947403..948182 1 NC_003116.1 NMA0982, len: 259 aa; unknown, similar to many hypothetical proteins e.g. SW:YCFH_ECOLI (EMBL:AE000210),ycfH, Escherichia coli hypothetical protein (265 aa),fasta scores; E(): 0, 44.7% identity in 255 aa overlap. Contains Pfam match to entry PF01026 UPF0006,Uncharacterized protein family and PS01137 Uncharacterized protein family UPF0006 signature 1; hypothetical protein 948182 906959 NMA0982 Neisseria meningitidis Z2491 hypothetical protein YP_002342404.1 947403 D 122587 CDS YP_002342405.1 218767893 906961 948538..948849 1 NC_003116.1 NMA0984, len: 103 aa; unknown, similar to many hypothetical proteins, some of which are glutaredoxin-like e.g. SW:YI46_SYNY3 (EMBL:D90903) Synechocystis sp. hypothetical protein (107 aa), fasta scores; E(): 7.4e-24,62.5% identity in 96 aa overlap. No N-terminal CXXC active site residues are apparent in this CDS; hypothetical protein 948849 906961 NMA0984 Neisseria meningitidis Z2491 hypothetical protein YP_002342405.1 948538 D 122587 CDS YP_002342406.1 218767894 906962 948955..949581 1 NC_003116.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 949581 upp 906962 upp Neisseria meningitidis Z2491 uracil phosphoribosyltransferase YP_002342406.1 948955 D 122587 CDS YP_002342407.1 218767895 906963 949604..949924 1 NC_003116.1 NMA0986, len: 106 aa; unknown; hypothetical protein 949924 906963 NMA0986 Neisseria meningitidis Z2491 hypothetical protein YP_002342407.1 949604 D 122587 CDS YP_002342408.1 218767896 906964 950175..950597 1 NC_003116.1 NMA0987, probable secreted protein, len: 140 aa; unknown, highly similar to TR:O30392 (EMBL:AF003941),gly1ORF1, Neisseria gonorrhoeae PilA-regulated protein (140 aa), fasta scores; E(): 0, 97.9% identity in 140 aa overlap. Found in outer membrane preparations of wild-type N. gonorrhoeae. A knockout of the gly1 locus results in increased toxicity of the strain to human fallopian tube organ cultures. Contains an N-terminal signal sequence; secreted protein 950597 906964 NMA0987 Neisseria meningitidis Z2491 secreted protein YP_002342408.1 950175 D 122587 CDS YP_002342409.1 218767897 906965 950636..951376 1 NC_003116.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 951376 hemD 906965 hemD Neisseria meningitidis Z2491 uroporphyrinogen-III synthase YP_002342409.1 950636 D 122587 CDS YP_002342410.1 218767898 906966 951451..952725 1 NC_003116.1 NMA0989, len: 424 aa; unknown, shows weak similarity to uroporphyrin-III C-methyltransferase from Escherichia coli and Haemophilus influenzae, e.g. SW:HEMX_ECOLI (EMBL:X13406), hemX,Escherichia coli uroporphyrin-III C-methyltransferase (EC 2.1.1.107) (393 aa), fasta scores; E(): 8.1e-17, 25.4% identity in 389 aa overlap; hypothetical protein 952725 906966 NMA0989 Neisseria meningitidis Z2491 hypothetical protein YP_002342410.1 951451 D 122587 CDS YP_002342411.1 218767899 906967 952722..953939 1 NC_003116.1 NMA0990, len: 405 aa; unknown; hypothetical protein 953939 906967 NMA0990 Neisseria meningitidis Z2491 hypothetical protein YP_002342411.1 952722 D 122587 CDS YP_002342412.1 218767900 906968 954014..955078 1 NC_003116.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 955078 hemE 906968 hemE Neisseria meningitidis Z2491 uroporphyrinogen decarboxylase YP_002342412.1 954014 D 122587 CDS YP_002342413.1 218767901 906969 955264..956643 1 NC_003116.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 956643 radA 906969 radA Neisseria meningitidis Z2491 DNA repair protein RadA YP_002342413.1 955264 D 122587 CDS YP_002342414.1 218767902 906970 complement(956919..957398) 1 NC_003116.1 NMA0993, periplasmic protein, len: 159 aa; unknown, similar to TR:O83865 (EMBL:AE001259) Treponema pallidum hypothetical protein (168 aa), fasta scores; E(): 2.1e-16, 35.9% identity in 153 aa overlap. Contains a N-terminal signal sequence; hypothetical protein 957398 906970 NMA0993 Neisseria meningitidis Z2491 hypothetical protein YP_002342414.1 956919 R 122587 CDS YP_002342415.1 218767903 906971 complement(957530..957889) 1 NC_003116.1 NMA0994, periplasmic protein, len: 119 aa; unknown, shows weak similarity to SW:PSPE_ECOLI (EMBL:X57560), pspE, Escherichia coli phage shock protein (104 aa), fasta scores; E(): 1.9e-09, 40.9% identity in 88 aa overlap. Contains Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain. Contains a N-terminal signal sequence; hypothetical protein 957889 906971 NMA0994 Neisseria meningitidis Z2491 hypothetical protein YP_002342415.1 957530 R 122587 CDS YP_002342416.1 218767904 906972 complement(957928..961542) 1 NC_003116.1 NMA0995, recB, probable exodeoxyribonuclease V beta chain, len: 1204 aa; similar to bacterial deoxyribonucleases e.g. SW:EX5B_ECOLI (EMBL:X04581), recB,Escherichia coli exodeoxyribonuclease V beta chain (EC 3.1.11.5) (1180 aa),fasta scores; E(): 0, 32.2% identity in 1241 aa overlap. Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase and two PS00017 ATP/GTP-binding site motif A (P-loop); exodeoxyribonuclease V subunit beta 961542 906972 NMA0995 Neisseria meningitidis Z2491 exodeoxyribonuclease V subunit beta YP_002342416.1 957928 R 122587 CDS YP_002342417.1 218767905 906973 complement(961775..962683) 1 NC_003116.1 NMA0996, len: 302 aa; unknown, similar to TR:P76536 (EMBL:AE000330) Escherichia coli hypothetical protein (308 aa), fasta scores; E(): 0, 49.7% identity in 302 aa overlap and TR:O07180 (EMBL:Z96797) Mycobacterium tuberculosis hypothetical protein (335 aa), fasta scores; E(): 5.3e-33, 34.5% identity in 304 aa overlap; hypothetical protein 962683 906973 NMA0996 Neisseria meningitidis Z2491 hypothetical protein YP_002342417.1 961775 R 122587 CDS YP_002342418.1 218767906 906974 962968..963795 1 NC_003116.1 NMA0997, probable amino acid permease substrate-binding protein, len: 275 aa; similar to many e.g. SW:HISJ_ECOLI (EMBL:U47027), hisJ, Escherichia coli histidine-binding periplasmic protein precursor (260 aa),fasta scores; E(): 5.2e-13, 27.6% identity in 232 aa overlap. Similar to many hypothetical binding proteins e.g. TR:Q9ZKR0 (EMBL:AE001517) Helicobacter pylori J99 amino acid abc transporter, binding protein precursor (257 aa), fasta scores; E(): 0, 54.4% identity in 237 aa overlap. Contains Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, PS01039 Bacterial extracellular solute-binding proteins, family 3 signature and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; amino acid permease 963795 906974 NMA0997 Neisseria meningitidis Z2491 amino acid permease YP_002342418.1 962968 D 122587 CDS YP_002342419.1 218767907 906975 963785..964501 1 NC_003116.1 NMA0999, probable amino acid permease integral membrane protein, len: 238 aa; similar to many e.g. SW:GLNP_ECOLI (EMBL:X14180), glnP, Escherichia coli glutamine transport system permease (219 aa),fasta scores; E(): 1.2e-20, 34.0% identity in 209 aa overlap. Similar to many hypothetical permease integral membrane proteins e.g. TR:Q9ZKR1 (EMBL:AE001517) Helicobacter pylori J99 amino acid abc transporter, permease (237 aa), fasta scores; E(): 0, 58.4% identity in 226 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains hydrophobic, probable membrane-spanning regions; amino acid permease integral membrane protein 964501 906975 NMA0999 Neisseria meningitidis Z2491 amino acid permease integral membrane protein YP_002342419.1 963785 D 122587 CDS YP_002342420.1 218767908 906976 964511..965266 1 NC_003116.1 NMA1000, probable amino acid permease ATP-binding protein, len: 251 aa; similar to many e.g. SW:GLNQ_BACST (EMBL:M61017), glnQ, Bacillus stearothermophilus glutamine transport ATP-binding protein (242 aa), E(): 0, 52.6% identity in 247 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); amino acid permease ATP-binding protein 965266 906976 NMA1000 Neisseria meningitidis Z2491 amino acid permease ATP-binding protein YP_002342420.1 964511 D 122587 CDS YP_002342421.1 218767909 906977 complement(965286..966668) 1 NC_003116.1 NMA1001, pgm, phosphoglucomutase, len: 460 aa; highly similar to SW:PGMU_NEIME (EMBL:U02490), pgm,Neisseria meningitidis strain NMB phosphoglucomutase (EC 5.4.2.2) (460 aa), fasta scores; E(): 0, 94.3% identity in 460 aa overlap. Contains Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase and PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature; phosphoglucomutase 966668 906977 NMA1001 Neisseria meningitidis Z2491 phosphoglucomutase YP_002342421.1 965286 R 122587 CDS YP_002342422.1 218767910 906978 complement(966831..967340) 1 NC_003116.1 NMA1002, ppiB, probable peptidyl-prolyl cis-trans isomerase B, len: 169 aa; similar to many e.g. SW:CYPB_ECOLI (EMBL:M55430), ppiB, Escherichia coli peptidyl-prolyl cis-trans isomerase B (EC 5.2.1.8) (164 aa), fasta scores; E(): 0, 58.9% identity in 163 aa overlap. Also similar to NMA1469, fasta scores; E(): 2.3e-21, 46.3% identity in 162 aa overlap. Contains Pfam match to entry PF00160 pro_isomerase, Peptidyl-prolyl cis-trans isomerase and PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature; peptidyl-prolyl cis-trans isomerase B 967340 906978 NMA1002 Neisseria meningitidis Z2491 peptidyl-prolyl cis-trans isomerase B YP_002342422.1 966831 R 122587 CDS YP_002342423.1 218767911 906979 complement(967459..968874) 1 NC_003116.1 NMA1003, probable transmembrane transport protein,len: 471 aa; similar to many e.g. to part of SW:PH87_YEAST (EMBL:X56909), PHO87, Saccharomyces cerevisiae inorganic phosphate transporter (923 aa), fasta scores; E(): 6.2e-20, 27.1% identity in 425 aa overlap and to hypothetical transporters e.g. SW:Y608_HAEIN (EMBL:U32743), HI0608, Haemophilus influenzae hypothetical protein (461 aa), fasta scores; E(): 0, 56.3% identity in 448 aa overlap. Contains Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region and PS01271 Sodium:sulfate symporter family signature. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein 968874 906979 NMA1003 Neisseria meningitidis Z2491 transmembrane transport protein YP_002342423.1 967459 R 122587 CDS YP_002342424.1 218767912 7163865 complement(969207..969467) 1 NC_003116.1 hypothetical protein 969467 7163865 NMA1003A Neisseria meningitidis Z2491 hypothetical protein YP_002342424.1 969207 R 122587 CDS YP_002342425.1 218767913 906980 complement(969731..970309) 1 NC_003116.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 970309 pth 906980 pth Neisseria meningitidis Z2491 peptidyl-tRNA hydrolase YP_002342425.1 969731 R 122587 CDS YP_002342426.1 218767914 906981 complement(970362..970640) 1 NC_003116.1 NMA1005, len: 92 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YFJF_HAEIN (EMBL:U32723),HI0395, Haemophilus influenzae hypothetical protein (102 aa), fasta scores; E(): 2.6e-14, 48.3% identity in 89 aa overlap; hypothetical protein 970640 906981 NMA1005 Neisseria meningitidis Z2491 hypothetical protein YP_002342426.1 970362 R 122587 CDS YP_002342427.1 218767915 906982 complement(970633..971076) 1 NC_003116.1 NMA1006, len: 147 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:O68560 (EMBL:AF050676) Pseudomonas aeruginosa hypothetical protein (144 aa),fasta scores; E(): 1.8e-17, 34.5% identity in 139 aa overlap; hypothetical protein 971076 906982 NMA1006 Neisseria meningitidis Z2491 hypothetical protein YP_002342427.1 970633 R 122587 CDS YP_002342428.1 218767916 906983 complement(971286..973253) 1 NC_003116.1 NMA1007, ftsH, probable ATP-dependent zinc metallopeptidase, len: 655 aa; similar to many e.g. SW:FTSH_ECOLI (EMBL:M83138), ftsH, Escherichia coli cell division protein (EC 3.4.24.-) (644 aa), fasta scores; E(): 0, 58.5% identity in 646 aa overlap. Contains Pfam matches to entry PF00004 AAA, ATPases associated with various cellular activities (AAA) and to entry PF01434 Peptidase_M41, Peptidase family M41, PS00674 AAA-protein family signature and two PS00017 ATP/GTP-binding site motif A (P-loop). Contains hydrophobic, probable membrane-spanning regions; ATP-dependent zinc metallopeptidase 973253 906983 NMA1007 Neisseria meningitidis Z2491 ATP-dependent zinc metallopeptidase YP_002342428.1 971286 R 122587 CDS YP_002342429.1 218767917 906984 complement(973317..973937) 1 NC_003116.1 NMA1008, ftsJ, probable cell division protein, len: 106 aa; similar to many e.g. SW:FTSJ_ECOLI (EMBL:M83138),ftsJ, Escherichia coli cell division protein (209 aa),fasta scores; E(): 0, 49.0% identity in 204 aa overlap; cell division protein 973937 906984 NMA1008 Neisseria meningitidis Z2491 cell division protein YP_002342429.1 973317 R 122587 CDS YP_002342430.1 218767918 906985 974047..974331 1 NC_003116.1 NMA1009, len: 94 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YHBY_HAEIN (EMBL:U32812),HI1333, Haemophilus influenzae hypothetical protein (99 aa), fasta scores; E(): 5.3e-12, 48.9% identity in 90 aa overlap; hypothetical protein 974331 906985 NMA1009 Neisseria meningitidis Z2491 hypothetical protein YP_002342430.1 974047 D 122587 CDS YP_002342431.1 218767919 906987 974499..975515 1 NC_003116.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 975515 hemB 906987 hemB Neisseria meningitidis Z2491 delta-aminolevulinic acid dehydratase YP_002342431.1 974499 D 122587 CDS YP_002342432.1 218767920 906988 complement(975578..976735) 1 NC_003116.1 NMA1012, probable carbon-sulphur lyase, len: 385 aa; similar to many members of the pyridoxal-phosphate dependent cysteine and methionine metabolism family e.g. SW:MEGL_PSEPU (EMBL:D88554), mdeA, Pseudomonas putida methionine gamma-lyase (EC 4.4.1.11) (398 aa), fasta scores; E(): 0, 39.3% identity in 402 aa overlap and SW:METB_ECOLI (EMBL:K01546), metB, Escherichia coli cystathionine gamma-synthase (EC 4.2.99.9) (386 aa), fasta scores; E(): 0, 39.4% identity in 376 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site; carbon-sulfur lyase 976735 906988 NMA1012 Neisseria meningitidis Z2491 carbon-sulfur lyase YP_002342432.1 975578 R 122587 CDS YP_002342433.1 218767921 906989 976927..977700 1 NC_003116.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis; GTP cyclohydrolase 977700 906989 NMA1013 Neisseria meningitidis Z2491 GTP cyclohydrolase YP_002342433.1 976927 D 122587 CDS YP_002342434.1 218767922 906991 977900..978565 1 NC_003116.1 NMA1015, probable NAD(P)H-flavin oxidoreductase,len: 221 aa; similar to many e.g. SW:NFNB_SALTY (EMBL:X17250), nfnB, Salmonella typhimurium oxygen-insensitive NAD(P)H nitroreductase (EC 1.-.-.-) (217 aa), fasta scores; E(): 8.7e-13, 31.4% identity in 223 aa overlap and SW:NFNB_ECOLI (EMBL:D25414), nfnB,Escherichia coli dihydropteridine reductase (EC 1.6.99.7) (217 aa), fasta scores; E(): 3.6e-11, 31.5% identity in 219 aa overlap. Contains Pfam match to entry PF00881 Nitroreductase, Nitroreductase family; NAD(P)H-flavin oxidoreductase 978565 906991 NMA1015 Neisseria meningitidis Z2491 NAD(P)H-flavin oxidoreductase YP_002342434.1 977900 D 122587 CDS YP_002342435.1 218767923 906992 complement(978620..979378) 1 NC_003116.1 NMA1016, probable RNA-binding protein, len: 252 aa; shows weak similarity to pseudouridine synthases e.g. SW:RSUA_ECOLI (EMBL:U00008), rluA, Escherichia coli ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) (231 aa), fasta scores; E(): 1.4e-09, 30.2% identity in 242 aa overlap. Also shows weak similarity to NMA1573, fasta scores; E(): 4.2e-13, 35.5% identity in 248 aa overlap and NMA1508, fasta scores; E(): 2.7e-10, 26.1% identity in 241 aa overlap. Contains Pfam match to entry PF01479 S4, S4 domain; RNA-binding protein 979378 906992 NMA1016 Neisseria meningitidis Z2491 RNA-binding protein YP_002342435.1 978620 R 122587 CDS YP_002342436.1 218767924 906993 complement(979403..980293) 1 NC_003116.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 980293 ppnK 906993 ppnK Neisseria meningitidis Z2491 inorganic polyphosphate/ATP-NAD kinase YP_002342436.1 979403 R 122587 CDS YP_002342437.1 218767925 906994 complement(980313..980879) 1 NC_003116.1 NMA1018, len: 188 aa; unknown; hypothetical protein 980879 906994 NMA1018 Neisseria meningitidis Z2491 hypothetical protein YP_002342437.1 980313 R 122587 CDS YP_002342438.1 218767926 906995 complement(980930..981706) 1 NC_003116.1 NMA1019, len: 258 aa; unknown, similar to SW:YEEZ_ECOLI (EMBL:AE000293), yeeZ, Escherichia coli hypothetical protein (274 aa), fasta scores; E(): 6e-17,30.9% identity in 256 aa overlap; hypothetical protein 981706 906995 NMA1019 Neisseria meningitidis Z2491 hypothetical protein YP_002342438.1 980930 R 122587 CDS YP_002342439.1 218767927 906996 complement(981761..982411) 1 NC_003116.1 NMA1020, probable tetR-family transcriptional regulator, len: 216 aa; similar to many e.g. to the N-terminus of TR:Q9Z480 (EMBL:AF090987), tetR,Agrobacterium tumefaciens C58 transcriptional repressor (215 aa), fasta scores; E(): 0.00072, 40.0% identity in 75 aa overlap and to regulators e.g. .Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Contains a probable helix-turn-helix motif at aa 32-53 (Score 1664, +4.85 SD); tetR-family transcriptional regulator 982411 906996 NMA1020 Neisseria meningitidis Z2491 tetR-family transcriptional regulator YP_002342439.1 981761 R 122587 CDS YP_002342440.1 218767928 906997 complement(982423..983463) 1 NC_003116.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 983463 murB 906997 murB Neisseria meningitidis Z2491 UDP-N-acetylenolpyruvoylglucosamine reductase YP_002342440.1 982423 R 122587 CDS YP_002342441.1 218767929 906998 complement(983641..985020) 1 NC_003116.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 985020 906998 NMA1022 Neisseria meningitidis Z2491 multidrug efflux protein YP_002342441.1 983641 R 122587 CDS YP_002342442.1 218767930 906999 985355..986506 1 NC_003116.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine; ATP phosphoribosyltransferase 986506 hisZ 906999 hisZ Neisseria meningitidis Z2491 ATP phosphoribosyltransferase YP_002342442.1 985355 D 122587 CDS YP_002342443.1 218767931 907000 986609..987907 1 NC_003116.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 987907 purA 907000 purA Neisseria meningitidis Z2491 adenylosuccinate synthetase YP_002342443.1 986609 D 122587 CDS YP_002342444.1 218767932 907001 988026..988286 1 NC_003116.1 NMA1025, len: 86 aa; unknown; hypothetical protein 988286 907001 NMA1025 Neisseria meningitidis Z2491 hypothetical protein YP_002342444.1 988026 D 122587 CDS YP_002342445.1 218767933 907002 988319..988756 1 NC_003116.1 NMA1026, len: 127 aa; unknown, similar to others from Neisseria meningitidis e.g. NMA1028, fasta scores; E(): 1.3e-13, 35.4% identity in 130 aa overlap, also to NMA1027 and NMA0096; hypothetical protein 988756 907002 NMA1026 Neisseria meningitidis Z2491 hypothetical protein YP_002342445.1 988319 D 122587 CDS YP_002342446.1 218767934 907003 988770..989180 1 NC_003116.1 NMA1027, DNA-binding protein, len: 136 aa; similar to others from Neisseria meningitidis e.g. NMA1028, fasta scores; E(): 7e-21, 42.7% identity in 131 aa overlap, also to NMA0096 and NMA1026. Contains probable helix-turn-helix motif at aa 96-117 (Score 1404, +3.97 SD); DNA-binding protein 989180 907003 NMA1027 Neisseria meningitidis Z2491 DNA-binding protein YP_002342446.1 988770 D 122587 CDS YP_002342447.1 218767935 907004 989297..989689 1 NC_003116.1 NMA1028, DNA-binding protein, len: 130 aa; similar to others from Neisseria meningitidis e.g. NMA1027, fasta scores; E(): 1.4e-20, 42.7% identity in 131 aa overlap, also to NMA0096 and NMA1026. Contains probable helix-turn-helix motif at aa 90-111 (Score 1103, +2.94 SD); DNA-binding protein 989689 907004 NMA1028 Neisseria meningitidis Z2491 DNA-binding protein YP_002342447.1 989297 D 122587 CDS YP_002342448.1 218767936 907006 989952..990455 1 NC_003116.1 NMA1030, len: 167 aa; unknown; hypothetical protein 990455 907006 NMA1030 Neisseria meningitidis Z2491 hypothetical protein YP_002342448.1 989952 D 122587 CDS YP_002342449.1 218767937 907007 complement(990756..991595) 1 NC_003116.1 metalloprotease; heat shock protein HtpX 991595 htpX 907007 htpX Neisseria meningitidis Z2491 heat shock protein HtpX YP_002342449.1 990756 R 122587 CDS YP_002342450.1 218767938 907008 991810..992457 1 NC_003116.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 992457 adk 907008 adk Neisseria meningitidis Z2491 adenylate kinase YP_002342450.1 991810 D 122587 CDS YP_002342451.1 218767939 907009 992983..993723 1 NC_003116.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 993723 pyrF 907009 pyrF Neisseria meningitidis Z2491 orotidine 5'-phosphate decarboxylase YP_002342451.1 992983 D 122587 CDS YP_002342452.1 218767940 907010 993778..994749 1 NC_003116.1 NMA1034, rfaE, probable ADP-heptose synthetase,len: 323 aa; similar to many e.g. SW:RFAE_ECOLI (EMBL:AE000387), rfaE, Escherichia coli ADP-heptose synthase (EC 2.7.-.-) (477 aa), fasta scores; E(): 0,50.5% identity in 309 aa overlap and to TR:AAD32179 (EMBL:AF125564), rfaE, Neisseria meningitidis ADP-heptose synthetase (fragment) (313 aa), fasta scores; E(): 0, 96.8% identity in 313 aa overlap. Contains PS00583 pfkB family of carbohydrate kinases signature 1; DP-heptose synthetase 994749 907010 NMA1034 Neisseria meningitidis Z2491 DP-heptose synthetase YP_002342452.1 993778 D 122587 CDS YP_002342453.1 218767941 907011 994786..996021 1 NC_003116.1 NMA1035, nmgII, probable modification methylase,len: 411 aa; similar to many e.g. SW:MTS2_SHISO (EMBL:M86545), ssoIIM, Shigella sonnei modification methylase (EC ) (379 aa), fasta scores; E(): 6e-30, 31.7% identity in 398 aa overlap and to TR:AAD32180 (EMBL:AF125564), nmgII, Neisseria meningitidis NMB site specific dna methyltransferase (411 aa),E(): 0, 99.3% identity in 411 aa overlap. Similar to others from Neisseria meningitidis e.g. NMA1453, fasta scores; E(): 1.6e-23, 29.4% identity in 432 aa overlap. Contains two Pfam matches to entry PF00145 DNA_methylase,C-5 cytosine-specific DNA methylase, PS00095 C-5 cytosine-specific DNA methylases C-terminal signature and PS00094 C-5 cytosine-specific DNA methylases active site; modification methylase 996021 907011 NMA1035 Neisseria meningitidis Z2491 modification methylase YP_002342453.1 994786 D 122587 CDS YP_002342454.1 218767942 907012 996023..997141 1 NC_003116.1 NMA1036, nmgI, type II restriction endonuclease, len: 372 aa; shows weak similarity to the C-termini of restriction endonucleases e.g. TR:O30359 (EMBL:AF001598), dcrH, Neisseria gonorrhoeae restriction endonuclease (374 aa), fasta scores; E(): 1e-05, 33.0% identity in 109 aa overlap. Similar to TR:AAD32181 (EMBL:AF125564), nmgI, Neisseria meningitidis NMB restriction endonuclease (374 aa), fasta scores; E(): 0,97.9% identity in 374 aa overlap. Lies within a region of unusually low GC content, adjacent to a modification methylase; type II restriction endonuclease 997141 907012 NMA1036 Neisseria meningitidis Z2491 type II restriction endonuclease YP_002342454.1 996023 D 122587 CDS YP_002342455.1 218767943 907013 997182..998186 1 NC_003116.1 NMA1037, rfaD, probable ADP-L-glycero-D-mannoheptose epimerase, len: 334 aa; similar to many e.g. SW:RFAD_ECOLI (EMBL:M33577), rfaD,Escherichia coli ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) (310 aa), fasta scores; E(): 0, 52.7% identity in 328 aa overlap. Also highly similar to TR:Q51061 (EMBL:L07845), gme, Neisseria gonorrhoeae ADP-L-glycero-D-mannoheptose epimerase (334 aa), fasta scores; E(): 0, 97.0% identity in 334 aa overlap. Similar to others from Neisseria meningitidis e.g. NMA0203, fasta scores; E(): 9.3e-10, 25.5% identity in 333 aa overlap,also similar to NMA0189 and NMA0204. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family; ADP-L-glycero-D-mannoheptose epimerase 998186 907013 NMA1037 Neisseria meningitidis Z2491 ADP-L-glycero-D-mannoheptose epimerase YP_002342455.1 997182 D 122587 CDS YP_002342456.1 218767944 907014 998259..999803 1 NC_003116.1 NMA1038, probable type I restriction-modification system protein, len: 514 aa; similar to many e.g. SW:T1M1_ECOLI (EMBL:X13145), hsdM, Escherichia coli type I restriction enzyme protein M (EC 2.1.1.72) (520 aa), fasta scores; E(): 0, 75.8% identity in 512 aa overlap. Contains PS00092 N-6 Adenine-specific DNA methylases signature; type I restriction-modification system protein 999803 907014 NMA1038 Neisseria meningitidis Z2491 type I restriction-modification system protein YP_002342456.1 998259 D 122587 CDS YP_002342457.1 218767945 907015 999800..1000810 1 NC_003116.1 NMA1039, DNA-binding protein, len: 336 aa; similar, in part, to TR:Q9Z627 (EMBL:AF106566), rhuM,Salmonella typhimurium hypothetical protein from SPI-3 pathogenicity island (215 aa), fasta scores; E(): 7.8e-28,43.9% identity in 187 aa overlap. Contains a probable helix-turn-helix motif at aa 27-48 (Score 1542, +4.44 SD); DNA-binding protein 1000810 907015 NMA1039 Neisseria meningitidis Z2491 DNA-binding protein YP_002342457.1 999800 D 122587 CDS YP_002342458.1 218767946 907018 complement(1005418..1007697) 1 NC_003116.1 NMA1045, clpA, probable ATP-dependent protease ATP-binding protein, len: 759 aa; similar to many e.g. SW:CLPA_ECOLI (EMBL:M31045), clpA, Escherichia coli ATP-dependent Clp protease ATP-binding subunit (758 aa),fasta scores; E(): 0, 56.2% identity in 762 aa overlap. Similar to NMA1683, fasta scores; E(): 0, 37.2% identity in 844 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B, PS00870 Chaperonins clpA/B signature 1, PS00871 Chaperonins clpA/B signature 2 and two PS00017 ATP/GTP-binding site motif A (P-loop); ATP-dependent protease ATP-binding protein 1007697 907018 NMA1045 Neisseria meningitidis Z2491 ATP-dependent protease ATP-binding protein YP_002342458.1 1005418 R 122587 CDS YP_002342459.1 218767947 907019 complement(1007701..1008012) 1 NC_003116.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1008012 clpS 907019 clpS Neisseria meningitidis Z2491 ATP-dependent Clp protease adaptor protein ClpS YP_002342459.1 1007701 R 122587 CDS YP_002342460.1 218767948 907020 1008270..1008473 1 NC_003116.1 NMA1047, cspA, probable transcriptional regulator,len: 67 aa; similar to many cold-shock proteins e.g. SW:CSPA_ECOLI (EMBL:M30139), cspA, Escherichia coli cold shock protein (69 aa), fasta scores; E(): 1e-15, 64.5% identity in 62 aa overlap. Contains PS00352 'Cold-shock' DNA-binding domain signature; transcriptional regulator 1008473 907020 NMA1047 Neisseria meningitidis Z2491 transcriptional regulator YP_002342460.1 1008270 D 122587 CDS YP_002342461.1 218767949 907021 complement(1008771..1010102) 1 NC_003116.1 NMA1048, len: 443 aa; unknown, similar to many e.g. SW:PMBA_ECOLI (EMBL:X54152), pmbA, Escherichia coli protein possibly involved in the control of DNA gyrase (450 aa), fasta scores; E(): 0, 50.4% identity in 425 aa overlap. Contains Pfam match to entry PF01523 PmbA_TldD, modulator of DNA gyrase; hypothetical protein 1010102 907021 NMA1048 Neisseria meningitidis Z2491 hypothetical protein YP_002342461.1 1008771 R 122587 CDS YP_002342462.1 218767950 907022 1010193..1010768 1 NC_003116.1 NMA1049, len: 191 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YJGA_HAEIN (EMBL:U32794),HI1151, Haemophilus influenzae hypothetical protein (178 aa), fasta scores; E(): 9.4e-19, 36.4% identity in 176 aa overlap; hypothetical protein 1010768 907022 NMA1049 Neisseria meningitidis Z2491 hypothetical protein YP_002342462.1 1010193 D 122587 CDS YP_002342463.1 218767951 907023 1010815..1011528 1 NC_003116.1 NMA1051, membrane protein, len: 237 aa; unknown, contains probable N-terminal signal sequence and hydrophobic, membrane-spanning region; hypothetical protein 1011528 907023 NMA1051 Neisseria meningitidis Z2491 hypothetical protein YP_002342463.1 1010815 D 122587 CDS YP_002342464.1 218767952 907024 1011597..1013297 1 NC_003116.1 NMA1052, recJ, probable single-stranded-DNA-specific exonuclease, len: 566 aa; similar to many e.g. SW:RECJ_ECOLI (EMBL:M54884), recJ,Escherichia coli single-stranded-DNA-specific exonuclease (EC 3.1.-.-) (577 aa), fasta scores; E(): 0, 47.9% identity in 584 aa overlap. Contains Pfam match to entry PF01368 DHH, DHH family; single-stranded-DNA-specific exonuclease 1013297 907024 NMA1052 Neisseria meningitidis Z2491 single-stranded-DNA-specific exonuclease YP_002342464.1 1011597 D 122587 CDS YP_002342465.1 218767953 907025 1013598..1014959 1 NC_003116.1 NMA1053, pcnB, probable poly(A) polymerase, len: 453 aa; similar to many e.g. SW:PCNB_ECOLI (EMBL:M20574),pcnB, Escherichia coli poly(A) polymerase (EC 2.7.7.19) (472 aa), fasta scores; E(): 0, 41.3% identity in 441 aa overlap; poly(A) polymerase 1014959 907025 NMA1053 Neisseria meningitidis Z2491 poly(A) polymerase YP_002342465.1 1013598 D 122587 CDS YP_002342466.1 218767954 907026 1015129..1015455 1 NC_003116.1 NMA1054, periplasmic protein, len: 108 aa; unknown, contains probable N-terminal signal sequence; hypothetical protein 1015455 907026 NMA1054 Neisseria meningitidis Z2491 hypothetical protein YP_002342466.1 1015129 D 122587 CDS YP_002342467.1 218767955 907027 complement(1015560..1016513) 1 NC_003116.1 NMA1056, len: 317 aa; unknown, similar to many bacterial proteins of the phoH family e.g. SW:PHOL_ECOLI (EMBL:AE000170), ybeZ, Escherichia coli hypothetical protein (359 aa), fasta scores; E(): 0, 58.1% identity in 320 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1016513 907027 NMA1056 Neisseria meningitidis Z2491 hypothetical protein YP_002342467.1 1015560 R 122587 CDS YP_002342468.1 218767956 907030 1018045..1018749 1 NC_003116.1 NMA1059, periplasmic protein, len: 234 aa; unknown, contains probable N-terminal signal sequence; hypothetical protein 1018749 907030 NMA1059 Neisseria meningitidis Z2491 hypothetical protein YP_002342468.1 1018045 D 122587 CDS YP_002342469.1 218767957 907031 complement(1018813..1019379) 1 NC_003116.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1019379 dcd 907031 dcd Neisseria meningitidis Z2491 deoxycytidine triphosphate deaminase YP_002342469.1 1018813 R 122587 CDS YP_002342470.1 218767958 907032 complement(1019445..1019861) 1 NC_003116.1 NMA1061, periplasmic protein, len: 138 aa; unknown, contains probable N-terminal signal sequence; hypothetical protein 1019861 907032 NMA1061 Neisseria meningitidis Z2491 hypothetical protein YP_002342470.1 1019445 R 122587 CDS YP_002342471.1 218767959 907033 complement(1019913..1020812) 1 NC_003116.1 Required for efficient pilin antigenic variation; recombination associated protein 1020812 rdgC 907033 rdgC Neisseria meningitidis Z2491 recombination associated protein YP_002342471.1 1019913 R 122587 CDS YP_002342472.1 218767960 907034 complement(1020843..1022300) 1 NC_003116.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1022300 engA 907034 engA Neisseria meningitidis Z2491 GTP-binding protein EngA YP_002342472.1 1020843 R 122587 CDS YP_002342473.1 218767961 907035 complement(1022454..1023083) 1 NC_003116.1 NMA1064, membrane protein, len: 209 aa; similar to SW:GC_NEIGO (EMBL:AF058711) Neisseria gonorrhoeae unknown protein (209 aa), fasta scores; E(): 0, 98.1% identity in 209 aa overlap and to bacterial hypothetical proteins. Contains hydrophobic, membrane-spanning region; hypothetical protein 1023083 907035 NMA1064 Neisseria meningitidis Z2491 hypothetical protein YP_002342473.1 1022454 R 122587 CDS YP_002342474.1 218767962 907036 complement(1023084..1024379) 1 NC_003116.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1024379 hisS 907036 hisS Neisseria meningitidis Z2491 histidyl-tRNA synthetase YP_002342474.1 1023084 R 122587 CDS YP_002342475.1 218767963 907037 complement(1024473..1025129) 1 NC_003116.1 NMA1066, periplasmic protein, len: 218 aa; shows weak similarity to part of TR:O53037 (EMBL:U68399),hmcC, Haemophilus influenzae protein implicated in haemocin production (198 aa), fasta scores; E(): 4.3e-12,33.6% identity in 146 aa overlap. Also highly similar to other proteins from Neisseria meningitidis, NMA0173, fasta scores; E(): 0, 70.7% identity in 164 aa overlap and NMA0767, fasta scores; E(): 0, 88.3% identity in 128 aa overlap. Contains a probable N-terminal signal sequence; hypothetical protein 1025129 907037 NMA1066 Neisseria meningitidis Z2491 hypothetical protein YP_002342475.1 1024473 R 122587 CDS YP_002342476.1 218767964 907039 complement(1025411..1025947) 1 NC_003116.1 NMA1068, len: 178 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1025947 907039 NMA1068 Neisseria meningitidis Z2491 hypothetical protein YP_002342476.1 1025411 R 122587 CDS YP_002342477.1 218767965 907040 complement(1026115..1026315) 1 NC_003116.1 NMA1070, len: 66 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1026315 907040 NMA1070 Neisseria meningitidis Z2491 hypothetical protein YP_002342477.1 1026115 R 122587 CDS YP_002342478.1 218767966 907041 complement(1026430..1026849) 1 NC_003116.1 NMA1071, len: 139 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1026849 907041 NMA1071 Neisseria meningitidis Z2491 hypothetical protein YP_002342478.1 1026430 R 122587 CDS YP_002342479.1 218767967 907042 complement(1026907..1027272) 1 NC_003116.1 NMA1072, len: 121 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1027272 907042 NMA1072 Neisseria meningitidis Z2491 hypothetical protein YP_002342479.1 1026907 R 122587 CDS YP_002342480.1 218767968 907043 complement(1027254..1027799) 1 NC_003116.1 NMA1073, len: 181 aa; unknown, similar to parts others from Neisseria meningitidis e.g. NMA1083, fasta scores; E(): 3.3e-17, 65.6% identity in 93 aa overlap,also to NMA1078. Lies within a region of unusually low GC content; hypothetical protein 1027799 907043 NMA1073 Neisseria meningitidis Z2491 hypothetical protein YP_002342480.1 1027254 R 122587 CDS YP_002342481.1 218767969 907044 complement(1027962..1028234) 1 NC_003116.1 NMA1074, membrane protein, len: 90 aa; unknown, contains hydrophobic, membrane-spanning regions. Lies within a region of unusually low GC content; hypothetical protein 1028234 907044 NMA1074 Neisseria meningitidis Z2491 hypothetical protein YP_002342481.1 1027962 R 122587 CDS YP_002342482.1 218767970 907045 complement(1028500..1028790) 1 NC_003116.1 hypothetical protein 1028790 907045 NMA1075 Neisseria meningitidis Z2491 hypothetical protein YP_002342482.1 1028500 R 122587 CDS YP_002342483.1 218767971 907047 complement(1029110..1029358) 1 NC_003116.1 NMA1077, len: 82 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1029358 907047 NMA1077 Neisseria meningitidis Z2491 hypothetical protein YP_002342483.1 1029110 R 122587 CDS YP_002342484.1 218767972 907048 complement(1029404..1029772) 1 NC_003116.1 NMA1078, len: 122 aa; unknown, similar to parts others from Neisseria meningitidis e.g. NMA1073, fasta scores; E(): 8.4e-14, 64.6% identity in 79 aa overlap,also to NMA1083. Lies within a region of unusually low GC content; hypothetical protein 1029772 907048 NMA1078 Neisseria meningitidis Z2491 hypothetical protein YP_002342484.1 1029404 R 122587 CDS YP_002342485.1 218767973 907049 complement(1029914..1030159) 1 NC_003116.1 NMA1079, len: 81 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1030159 907049 NMA1079 Neisseria meningitidis Z2491 hypothetical protein YP_002342485.1 1029914 R 122587 CDS YP_002342486.1 218767974 907050 complement(1030388..1030504) 1 NC_003116.1 NMA1080, len: 38 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1030504 907050 NMA1080 Neisseria meningitidis Z2491 hypothetical protein YP_002342486.1 1030388 R 122587 CDS YP_002342487.1 218767975 907051 complement(1030563..1030850) 1 NC_003116.1 NMA1081, membrane protein, len: 95 aa; unknown, contains hydrophobic, membrane-spanning regions, lies within a region of unusually low GC content; hypothetical protein 1030850 907051 NMA1081 Neisseria meningitidis Z2491 hypothetical protein YP_002342487.1 1030563 R 122587 CDS YP_002342488.1 218767976 907052 complement(1031157..1031528) 1 NC_003116.1 NMA1082, len: 123 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1031528 907052 NMA1082 Neisseria meningitidis Z2491 hypothetical protein YP_002342488.1 1031157 R 122587 CDS YP_002342489.1 218767977 907053 complement(1031662..1032105) 1 NC_003116.1 NMA1083, periplasmic protein, len: 147 aa; unknown, similar to parts of other proteins from Neisseria meningitidis e.g. NMA1073, fasta scores; E(): 1.4e-17,65.6% identity in 93 aa overlap, also to NMA1078. Contains probable N-terminal signal sequence. Lies within a region of unusually low GC content; hypothetical protein 1032105 907053 NMA1083 Neisseria meningitidis Z2491 hypothetical protein YP_002342489.1 1031662 R 122587 CDS YP_002342490.1 218767978 907054 complement(1032148..1033017) 1 NC_003116.1 NMA1084, periplasmic protein, len: 289 aa; shows weak similarity to TR:O53036 (EMBL:U68399), hmcD,Haemophilus influenzae protein at haemocin immunity locus (297 aa), fasta scores; E(): 3.7e-07, 24.6% identity in 289 aa overlap. Similar to part of NMA0171, fasta scores; E(): 1.2e-09, 54.7% identity in 53 aa overlap. Contains probable N-terminal signal sequence; hypothetical protein 1033017 907054 NMA1084 Neisseria meningitidis Z2491 hypothetical protein YP_002342490.1 1032148 R 122587 CDS YP_002342491.1 218767979 907055 1033181..1034104 1 NC_003116.1 NMA1085, len: 307 aa; similar to TR:O07166 (EMBL:Z96070) Mycobacterium tuberculosis hypothetical protein (305 aa), fasta scores; E(): 0, 42.9% identity in 282 aa overlap and shows weak similarity to many,including pseudouridine synthases. Contains Pfam match to entry PF00849 YABO, Hypothetical yabO/yceC/sfhB family; hypothetical protein 1034104 907055 NMA1085 Neisseria meningitidis Z2491 hypothetical protein YP_002342491.1 1033181 D 122587 CDS YP_002342492.1 218767980 907056 complement(1034182..1034823) 1 NC_003116.1 NMA1086, len: 213 aa; shows weak similarity to TR:Q9ZD73 (EMBL:AJ235271), RP471, Rickettsia prowazekii hypothetical protein (238 aa), fasta scores; E(): 1.4e-10,30.3% identity in 198 aa overlap; hypothetical protein 1034823 907056 NMA1086 Neisseria meningitidis Z2491 hypothetical protein YP_002342492.1 1034182 R 122587 CDS YP_002342493.1 218767981 907057 complement(1034878..1035669) 1 NC_003116.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 1035669 907057 NMA1087 Neisseria meningitidis Z2491 spermidine synthase YP_002342493.1 1034878 R 122587 CDS YP_002342494.1 218767982 907058 1036052..1036843 1 NC_003116.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 1036843 panB 907058 panB Neisseria meningitidis Z2491 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_002342494.1 1036052 D 122587 CDS YP_002342495.1 218767983 907059 1036966..1037802 1 NC_003116.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 1037802 panC 907059 panC Neisseria meningitidis Z2491 pantoate--beta-alanine ligase YP_002342495.1 1036966 D 122587 CDS YP_002342496.1 218767984 907060 1037967..1039805 1 NC_003116.1 NMA1090, periplasmic protein, len: 612 aa; shows weak similarity to hypothetical proteins e.g. SW:YHE3_PSEAE (EMBL:X82071) Pseudomonas aeruginosa hypothetical protein (576 aa), fasta scores; E(): 1.7e-15,26.4% identity in 613 aa overlap. Contains probable N-terminal signal sequence; hypothetical protein 1039805 907060 NMA1090 Neisseria meningitidis Z2491 hypothetical protein YP_002342496.1 1037967 D 122587 CDS YP_002342497.1 218767985 907061 1039945..1040526 1 NC_003116.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1040526 lolB 907061 lolB Neisseria meningitidis Z2491 outer membrane lipoprotein LolB YP_002342497.1 1039945 D 122587 CDS YP_002342498.1 218767986 907062 1040536..1041381 1 NC_003116.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1041381 ipk 907062 ipk Neisseria meningitidis Z2491 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_002342498.1 1040536 D 122587 CDS YP_002342499.1 218767987 907063 1041803..1042786 1 NC_003116.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1042786 prsA 907063 prsA Neisseria meningitidis Z2491 ribose-phosphate pyrophosphokinase YP_002342499.1 1041803 D 122587 CDS YP_002342500.1 218767988 907064 1042853..1043425 1 NC_003116.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 1043425 907064 NMA1094 Neisseria meningitidis Z2491 50S ribosomal protein L25 YP_002342500.1 1042853 D 122587 CDS YP_002342501.1 218767989 907065 complement(1043550..1044719) 1 NC_003116.1 NMA1095, probable D-alanyl-D-alanine carboxypeptidase, len: 389 aa; similar to many e.g. SW:DACC_ECOLI (EMBL:X06480), dacC, Escherichia coli D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) (400 aa), fasta scores; E(): 0, 36.3% identity in 364 aa overlap. Similar to NMA0962, fasta scores; E(): 8.4e-14,29.6% identity in 243 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase. Contains probable N-terminal signal sequence; D-alanyl-D-alanine carboxypeptidase 1044719 907065 NMA1095 Neisseria meningitidis Z2491 D-alanyl-D-alanine carboxypeptidase YP_002342501.1 1043550 R 122587 CDS YP_002342502.1 218767990 907066 1044867..1046393 1 NC_003116.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 1046393 ilvA 907066 ilvA Neisseria meningitidis Z2491 threonine dehydratase YP_002342502.1 1044867 D 122587 CDS YP_002342503.1 218767991 907067 complement(1046450..1047523) 1 NC_003116.1 NMA1097, cysA, probable sulphate permease ATP-binding protein, len: 357 aa; similar to many e.g. SW:CYSA_ECOLI (EMBL:M32101), cysA, Escherichia coli sulfate transport ATP-binding protein (365 aa), fasta scores; E(): 0, 49.4% identity in 360 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter,PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); sulfate permease ATP-binding protein 1047523 907067 NMA1097 Neisseria meningitidis Z2491 sulfate permease ATP-binding protein YP_002342503.1 1046450 R 122587 CDS YP_002342504.1 218767992 907068 complement(1047520..1048380) 1 NC_003116.1 NMA1098, cysW, probable sulphate permease inner membrane protein, len: 286 aa; similar to many e.g. SW:CYSW_ECOLI (EMBL:M32101), cysW, Escherichia coli sulfate transport system permease (291 aa), fasta scores; E(): 0, 51.7% identity in 265 aa overlap. Contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component and PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains hydrophobic,probable membrane-spanning regions; sulfate permease inner membrane protein 1048380 907068 NMA1098 Neisseria meningitidis Z2491 sulfate permease inner membrane protein YP_002342504.1 1047520 R 122587 CDS YP_002342505.1 218767993 907070 complement(1048758..1049594) 1 NC_003116.1 NMA1100, cysU, probable sulphate permease inner membrane protein, len: 278 aa; similar to many e.g. SW:CYST_ECOLI (EMBL:M32101), cysU, Escherichia coli sulfate transport system permease (277 aa), fasta scores; E(): 0, 48.4% identity in 273 aa overlap. Contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component and PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains hydrophobic,probable membrane-spanning regions; sulfate permease inner membrane protein 1049594 907070 NMA1100 Neisseria meningitidis Z2491 sulfate permease inner membrane protein YP_002342505.1 1048758 R 122587 CDS YP_002342506.1 218767994 907071 1049885..1050217 1 NC_003116.1 NMA1101, len: 110 aa; unknown, Glu-rich protein; hypothetical protein 1050217 907071 NMA1101 Neisseria meningitidis Z2491 hypothetical protein YP_002342506.1 1049885 D 122587 CDS YP_002342507.1 218767995 907072 1050549..1051058 1 NC_003116.1 NMA1102, integral membrane protein, len: 169 aa; similar to bacterial hypothetical proteins e.g. SW:Y318_HAEIN (EMBL:U32717), HI0318, Haemophilus influenzae (172 aa), fasta scores; E(): 0, 56.2% identity in 169 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains hydrophobic, membrane-spanning regions. Lies within a region of unusually low GC content; integral membrane protein 1051058 907072 NMA1102 Neisseria meningitidis Z2491 integral membrane protein YP_002342507.1 1050549 D 122587 CDS YP_002342508.1 218767996 907073 complement(1052308..1052895) 1 NC_003116.1 NMA1104, sodB, probable superoxide dismutase, len: 195 aa; highly similar to many e.g. SW:SODF_BORPE (EMBL:X63055), sodF, Bordetella pertussis superoxide dismutase [Fe] (EC 1.15.1.1) (192 aa), fasta scores; E(): 0, 72.9% identity in 192 aa overlap. Contains Pfam match to entry PF00081 sodfe, Iron/manganese superoxide dismutases (SODM) and PS00088 Manganese and iron superoxide dismutases signature; superoxide dismutase 1052895 907073 NMA1104 Neisseria meningitidis Z2491 superoxide dismutase YP_002342508.1 1052308 R 122587 CDS YP_002342509.1 218767997 907074 1053058..1054464 1 NC_003116.1 unwinds double stranded DNA; replicative DNA helicase 1054464 dnaB 907074 dnaB Neisseria meningitidis Z2491 replicative DNA helicase YP_002342509.1 1053058 D 122587 CDS YP_002342510.1 218767998 907075 1054773..1055438 1 NC_003116.1 NMA1106, len: 221 aa; unknown, N-terminus is similar to the N-termini of fimbrial proteins e.g. TR:Q51528 (EMBL:L48934), fimT, Pseudomonas aeruginosa fimbrial protein (169 aa), fasta scores; E(): 0.00046,31.5% identity in 108 aa overlap. Contains N-terminal signal sequence, similar to that present in others from Neisseria meningitidis: NMA0264, NMA1110,NMA0726, NMA0424, which are all pilin-related; hypothetical protein 1055438 907075 NMA1106 Neisseria meningitidis Z2491 hypothetical protein YP_002342510.1 1054773 D 122587 CDS YP_002342511.1 218767999 907076 1055468..1056082 1 NC_003116.1 NMA1107, membrane protein, len: 204 aa; unknown, N-terminus is similar to the N-terminus of TR:Q57003 (EMBL:L36117), pilV, Pseudomonas aeruginosa gene required for type 4 fimbrial biogenesis (185 aa), fasta scores; E(): 0.00046, 25.1% identity in 183 aa overlap. Contains hydrophobic, membrane-spanning region near the N-terminus; hypothetical protein 1056082 907076 NMA1107 Neisseria meningitidis Z2491 hypothetical protein YP_002342511.1 1055468 D 122587 CDS YP_002342512.1 218768000 907077 1056079..1057077 1 NC_003116.1 NMA1108, membrane protein, len: 332 aa; unknown, contains hydrophobic, membrane-spanning region near the N-terminus; hypothetical protein 1057077 907077 NMA1108 Neisseria meningitidis Z2491 hypothetical protein YP_002342512.1 1056079 D 122587 CDS YP_002342513.1 218768001 907078 1057056..1057649 1 NC_003116.1 NMA1109, membrane protein, len: 197 aa; unknown, contains hydrophobic, membrane-spanning region near the N-terminus; hypothetical protein 1057649 907078 NMA1109 Neisseria meningitidis Z2491 hypothetical protein YP_002342513.1 1057056 D 122587 CDS YP_002342514.1 218768002 907079 1057639..1058127 1 NC_003116.1 NMA1110, probable pilin, len: 162 aa; similar to many e.g. SW:FMI_MORBO (EMBL:M32345) Moraxella bovis fimbrial protein I precursor (159 aa), fasta scores; E(): 6.4e-06, 28.1% identity in 153 aa overlap. Contains Pfam match to entry PF00114 pilin, Pilins (bacterial filaments) and PS00409 Prokaryotic N-terminal methylation site. Contains probable N-terminal signal sequence; pilin 1058127 907079 NMA1110 Neisseria meningitidis Z2491 pilin YP_002342514.1 1057639 D 122587 CDS YP_002342515.1 218768003 907080 complement(1059437..1059919) 1 NC_003116.1 NMA1111, len: 160 aa; shows weak similarity to N-terminal regions of bacterial hypothetical proteins e.g. SW:YGAZ_ECOLI (EMBL:AE000353), ygaZ, Escherichia coli hypothetical protein (245 aa), fasta scores; E(): 1.7e-05,28.4% identity in 116 aa overlap; hypothetical protein 1059919 907080 NMA1111 Neisseria meningitidis Z2491 hypothetical protein YP_002342515.1 1059437 R 122587 CDS YP_002342516.1 218768004 907081 1060062..1060514 1 NC_003116.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1060514 dut 907081 dut Neisseria meningitidis Z2491 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002342516.1 1060062 D 122587 CDS YP_002342517.1 218768005 907082 1060590..1061777 1 NC_003116.1 catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate; succinyldiaminopimelate transaminase 1061777 907082 NMA1113 Neisseria meningitidis Z2491 succinyldiaminopimelate transaminase YP_002342517.1 1060590 D 122587 CDS YP_002342518.1 218768006 907083 1062039..1062818 1 NC_003116.1 NMA1114, len: 259 aa; similar to bacterial hypothetical proteins e.g. SW:YAAA_ECOLI (EMBL:D10483),yaaA, Escherichia coli hypothetical protein (258 aa),fasta scores; E(): 0, 54.9% identity in 257 aa overlap; hypothetical protein 1062818 907083 NMA1114 Neisseria meningitidis Z2491 hypothetical protein YP_002342518.1 1062039 D 122587 CDS YP_002342519.1 218768007 907084 complement(1063489..1064496) 1 NC_003116.1 NMA1115, probable transposase for IS1106A3, len: 335 aa; similar to many e.g. TR:CAB44967 (EMBL:AJ242841),Neisseria meningitidis transposase for insertion element IS1106A3 (335 aa), fasta scores; E(): 0, 97.6% identity in 335 aa overlap; transposase for IS1106A3 1064496 907084 NMA1115 Neisseria meningitidis Z2491 transposase for IS1106A3 YP_002342519.1 1063489 R 122587 CDS YP_002342520.1 218768008 907085 complement(1065658..1067883) 1 NC_003116.1 NMA1116, icd, probable isocitrate dehydrogenase,len: 741 aa; similar to many e.g. SW:IDH_AZOVI (EMBL:D73443), icd, Azotobacter vinelandii isocitrate dehydrogenase (EC 1.1.1.42) (741 aa), fasta scores; E(): 0, 65.6% identity in 735 aa overlap; isocitrate dehydrogenase 1067883 907085 NMA1116 Neisseria meningitidis Z2491 isocitrate dehydrogenase YP_002342520.1 1065658 R 122587 CDS YP_002342521.1 218768009 907087 1068316..1069431 1 NC_003116.1 NMA1118, lst,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3- sialyltransferase, len: 371 aa; highly similar to sialyltransferases from other strains e.g. TR:P72097 (EMBL:U60661), lst, Neisseria meningitidis strains 406Y,NRCC and 4030 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3- sialyltransferase (EC 2.4.99.-) (371 aa), fasta scores; E(): 0, 98.9% identity in 371 aa overlap; CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1069431 907087 NMA1118 Neisseria meningitidis Z2491 CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase YP_002342521.1 1068316 D 122587 CDS YP_002342522.1 218768010 907088 complement(1069595..1070053) 1 NC_003116.1 NMA1119, probable C-type cytochrome, len: 152 aa; similar to many e.g. SW:C554_RHOSH (EMBL:L36880), cycF,Rhodobacter sphaeroides cytochrome C-554 precursor (153 aa), fasta scores; E(): 9.9e-06, 28.4% identity in 148 aa overlap. Contains Pfam match to entry PF01322 Cytochrome_C_2, Cytochrome C', PS00190 Cytochrome c family heme-binding site signature and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; C-type cytochrome 1070053 907088 NMA1119 Neisseria meningitidis Z2491 C-type cytochrome YP_002342522.1 1069595 R 122587 CDS YP_002342523.1 218768011 907089 1070172..1070993 1 NC_003116.1 NMA1120, probable oxidoreductase, len: 273 aa; similar to many oxidoreductases e.g. TR:O54197 (EMBL:AJ000671), car, Streptomyces clavuligerus clavulanate-9-aldehyde reductase (247 aa), fasta scores; E(): 2.1e-23, 36.6% identity in 238 aa overlap and SW:FABG_ECOLI (EMBL:M84991), fabG, Escherichia coli 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) (244 aa), fasta scores; E(): 1.1e-16, 32.8% identity in 201 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and PS00061 Short-chain dehydrogenases/reductases family signature; oxidoreductase 1070993 907089 NMA1120 Neisseria meningitidis Z2491 oxidoreductase YP_002342523.1 1070172 D 122587 CDS YP_002342524.1 218768012 907090 complement(1071044..1071490) 1 NC_003116.1 NMA1121, acyl-CoA hydrolase, len: 148 aa; shows weak similarity to part of SW:CTE2_RAT (EMBL:U49694) Rattus norvegicus cytosolic acyl coenzyme a thioester hydrolase (EC 3.1.2.2) (338 aa), fasta scores; E(): 4.2e-07, 31.0% identity in 113 aa overlap. Also similar to hypothetical proteins e.g. SW:YCIA_HAEIN (EMBL:U32765),HI0827, Haemophilus influenzae hypothetical protein (154 aa), fasta scores; E(): 0, 62.1% identity in 132 aa overlap. Similar to NMA1691, fasta scores; E(): 1.2e-08,27.6% identity in 127 aa overlap. Contains Pfam match to entry PF01662 Acyl-CoA_hydro, Cytosolic long-chain acyl-CoA thioester hydrolase; acyl-CoA hydrolase 1071490 907090 NMA1121 Neisseria meningitidis Z2491 acyl-CoA hydrolase YP_002342524.1 1071044 R 122587 CDS YP_002342525.1 218768013 907091 1071772..1072704 1 NC_003116.1 NMA1122, pip, probable proline iminopeptidase, len: 310 aa; similar to many e.g. SW:PIP_NEIGO (EMBL:Z25461),pip, Neisseria gonorrhoeae proline iminopeptidase (EC 3.4.11.5) (310 aa), fasta scores; E(): 0, 96.5% identity in 310 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold; proline iminopeptidase 1072704 907091 NMA1122 Neisseria meningitidis Z2491 proline iminopeptidase YP_002342525.1 1071772 D 122587 CDS YP_002342526.1 218768014 907092 complement(1072761..1073888) 1 NC_003116.1 NMA1123, lipoprotein, len: 375 aa; unknown, contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a N-terminal signal sequence; lipoprotein 1073888 907092 NMA1123 Neisseria meningitidis Z2491 lipoprotein YP_002342526.1 1072761 R 122587 CDS YP_002342527.1 218768015 907093 complement(1073966..1074841) 1 NC_003116.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 1074841 dapA 907093 dapA Neisseria meningitidis Z2491 dihydrodipicolinate synthase YP_002342527.1 1073966 R 122587 CDS YP_002342528.1 218768016 907094 1075149..1076540 1 NC_003116.1 NMA1126, probable transmembrane transport protein,len: 463 aa; similar to many from both prokaryotes and eukaryotes e.g. SW:UAPC_EMENI (EMBL:X79796), uapC,Emericella nidulans purine permease (580 aa), fasta scores; E(): 4.4e-22, 30.7% identity in 499 aa overlap. Also similar to hypothetical proteins e.g. SW:YGFO_ECOLI (EMBL:U28375), ygfO, Escherichia coli hypothetical protein (485 aa), fasta scores; E(): 0, 69.4% identity in 438 aa overlap. Contains Pfam match to entry PF00860 xan_ur_permease, Xanthine/uracil permeases family and PS01116 Xanthine/uracil permeases family signature. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein 1076540 907094 NMA1126 Neisseria meningitidis Z2491 transmembrane transport protein YP_002342528.1 1075149 D 122587 CDS YP_002342529.1 218768017 907095 complement(1076602..1077354) 1 NC_003116.1 NMA1127, RNA methylase, len: 261 aa; shows weak similarity to SW:TSNR_STRAZ (EMBL:X02392), tsnR,Streptomyces azureus rRNA (adenosine-2'-O-)-methyltransferase (EC 2.1.1.66) (269 aa), blastp scores; Expect = 4.0e-14. Similar to other hypothetical RNA methylases e.g. SW:YJFH_ECOLI (EMBL:U14003), yjfH, Escherichia coli hypothetical tRNA/tRNA methyltransferase (243 aa), fasta scores; E(): 0, 52.3% identity in 241 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family; RNA methylase 1077354 907095 NMA1127 Neisseria meningitidis Z2491 RNA methylase YP_002342529.1 1076602 R 122587 CDS YP_002342530.1 218768018 907096 complement(1077421..1077909) 1 NC_003116.1 NMA1128, membrane protein, len: 162 aa; similar to SW:YQGC_BACSU (EMBL:D84432), yqgC, Bacillus subtilis hypothetical protein (160 aa), fasta scores; E(): 3.6e-10, 34.2% identity in 161 aa overlap. Contains hydrophobic, membrane-spanning regions; hypothetical protein 1077909 907096 NMA1128 Neisseria meningitidis Z2491 hypothetical protein YP_002342530.1 1077421 R 122587 CDS YP_002342531.1 218768019 907097 complement(1077914..1078633) 1 NC_003116.1 Similar to Neisseria meningitidis cytidine and deoxycytidylate deaminase family protein nmb0933 SWALL:Q9JZR1 (EMBL:AE002444) (239 aa) fasta scores: E(): 2.8e-91, 97.49% id in 239 aa, and to Bacillus subtilis hypothetical protein YaaJ yaaJ SWALL:YAAJ_BACSU (SWALL:P21335) (161 aa) fasta scores: E(): 9e-21, 40.66% id in 150 aa; NMA1129, cytosine deaminase, len: 239 aa; shows weak similarity to many e.g. SW:FCA1_CANAL (EMBL:U55194), fca1, Candida albicans cytosine deaminase (EC 3.5.4.1) (150 aa), fasta scores; E(): 5.5e-08, 31.4% identity in 140 aa overlap. Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region and PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature; cytosine deaminase 1078633 907097 NMA1129 Neisseria meningitidis Z2491 cytosine deaminase YP_002342531.1 1077914 R 122587 CDS YP_002342532.1 218768020 907099 complement(1078637..1079578) 1 NC_003116.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 1079578 miaA 907099 miaA Neisseria meningitidis Z2491 tRNA delta(2)-isopentenylpyrophosphate transferase YP_002342532.1 1078637 R 122587 CDS YP_002342533.1 218768021 7163866 complement(1079957..1081330) 1 NC_003116.1 hypothetical protein 1081330 7163866 NMA1131 Neisseria meningitidis Z2491 hypothetical protein YP_002342533.1 1079957 R 122587 CDS YP_002342534.1 218768022 907102 1081568..1082128 1 NC_003116.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 1082128 efp 907102 efp Neisseria meningitidis Z2491 elongation factor P YP_002342534.1 1081568 D 122587 CDS YP_002342535.1 218768023 907103 complement(1082178..1083023) 1 NC_003116.1 NMA1134, lipoprotein, len: 281 aa; unknown, contains appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and probable N-terminal signal sequence; lipoprotein 1083023 907103 NMA1134 Neisseria meningitidis Z2491 lipoprotein YP_002342535.1 1082178 R 122587 CDS YP_002342536.1 218768024 907104 complement(1083140..1083721) 1 NC_003116.1 NMA1135, len: 193 aa; unknown, shows weak similarity to parts of hypothetical proteins e.g. TR:O32813 (EMBL:U80599) Lactococcus lactis hypothetical protein (207 aa), fasta scores; E(): 0.001, 25.6% identity in 121 aa overlap; hypothetical protein 1083721 907104 NMA1135 Neisseria meningitidis Z2491 hypothetical protein YP_002342536.1 1083140 R 122587 CDS YP_002342537.1 218768025 907105 complement(1083718..1084857) 1 NC_003116.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 1084857 metX 907105 metX Neisseria meningitidis Z2491 homoserine O-acetyltransferase YP_002342537.1 1083718 R 122587 CDS YP_002342538.1 218768026 907106 complement(1085479..1085604) 1 NC_003116.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 1085604 rpmJ 907106 rpmJ Neisseria meningitidis Z2491 50S ribosomal protein L36 YP_002342538.1 1085479 R 122587 CDS YP_002342539.1 218768027 907107 complement(1085604..1085879) 1 NC_003116.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1085879 rpmE2 907107 rpmE2 Neisseria meningitidis Z2491 50S ribosomal protein L31 YP_002342539.1 1085604 R 122587 CDS YP_002342540.1 218768028 907108 1086078..1086956 1 NC_003116.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 1086956 metF 907108 metF Neisseria meningitidis Z2491 5,10-methylenetetrahydrofolate reductase YP_002342540.1 1086078 D 122587 CDS YP_002342541.1 218768029 907109 1087095..1089371 1 NC_003116.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 1089371 metE 907109 metE Neisseria meningitidis Z2491 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_002342541.1 1087095 D 122587 CDS YP_002342542.1 218768030 907110 1089650..1090387 1 NC_003116.1 NMA1141, redoxin, len: 245 aa; similar to many from both bacteria and eukaryotes e.g. TR:AAD28242 (EMBL:AF121355) Arabidopsis thaliana peroxiredoxin (162 aa), fasta scores; E(): 2e-17, 39.9% identity in 158 aa overlap. Contains Pfam match to entry PF00578 AhpC-TSA,AhpC/TSA family; redoxin 1090387 907110 NMA1141 Neisseria meningitidis Z2491 redoxin YP_002342542.1 1089650 D 122587 CDS YP_002342543.1 218768031 907111 1090636..1092039 1 NC_003116.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 1092039 lpdA2 907111 lpdA2 Neisseria meningitidis Z2491 dihydrolipoamide dehydrogenase YP_002342543.1 1090636 D 122587 CDS YP_002342544.1 218768032 907112 1092318..1092695 1 NC_003116.1 NMA1143, sdhC, probable succinate dehydrogenase cytochrome B subunit, len: 125 aa; similar to many e.g. SW:DHSC_ECOLI (EMBL:J01619), sdhC, Escherichia coli succinate dehydrogenase cytochrome B-556 subunit (129 aa),fasta scores; E(): 1.4e-14, 39.8% identity in 123 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt,Succinate dehydrogenase cytochrome b subunit and PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. Contains hydrophobic, probable membrane-spanning regions; succinate dehydrogenase cytochrome B subunit 1092695 907112 NMA1143 Neisseria meningitidis Z2491 succinate dehydrogenase cytochrome B subunit YP_002342544.1 1092318 D 122587 CDS YP_002342545.1 218768033 907113 1092689..1093030 1 NC_003116.1 NMA1144, sdhD, probable succinate dehydrogenase hydrophobic membrane anchor protein, len: 113 aa; similar to SW:DHSD_ECOLI (EMBL:J01619), sdhD, Escherichia coli succinate dehydrogenase hydrophobic membrane anchor protein (115 aa), fasta scores; E(): 5e-13, 36.5% identity in 104 aa overlap. Also similar to TR:O83000 (EMBL:AB015757) Rhodoferax fermentans fumarate reductase cytochrome B small subunit (121 aa), fasta scores; E(): 1.8e-21, 48.6% identity in 111 aa overlap. Contains hydrophobic, probable membrane-spanning regions; succinate dehydrogenase hydrophobic membrane anchor protein 1093030 907113 NMA1144 Neisseria meningitidis Z2491 succinate dehydrogenase hydrophobic membrane anchor protein YP_002342545.1 1092689 D 122587 CDS YP_002342546.1 218768034 907114 1093033..1094796 1 NC_003116.1 NMA1145, sdhA, probable succinate dehydrogenase flavoprotein subunit, len: 587 aa; similar to many e.g. SW:DHSA_ECOLI (EMBL:J01619), sdhA, Escherichia coli succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) (588 aa), fasta scores; E(): 0, 56.6% identity in 590 aa overlap. Also similar to TR:O83001 (EMBL:AB015757) Rhodoferax fermentans fumarate reductase flavoprotein subunit (601 aa), fasta scores; E(): 0, 64.2% identity in 592 aa overlap. Similar to NMA2092, fasta scores; E(): 8.6e-31, 33.9% identity in 546 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain and PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site; succinate dehydrogenase flavoprotein subunit 1094796 907114 NMA1145 Neisseria meningitidis Z2491 succinate dehydrogenase flavoprotein subunit YP_002342546.1 1093033 D 122587 CDS YP_002342547.1 218768035 907115 1094916..1095623 1 NC_003116.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 1095623 sdhB 907115 sdhB Neisseria meningitidis Z2491 succinate dehydrogenase iron-sulfur subunit YP_002342547.1 1094916 D 122587 CDS YP_002342548.1 218768036 907116 1095627..1095875 1 NC_003116.1 NMA1147, len: 82 aa; shows weak similarity to bacterial hypothetical proteins e.g. TR:Q9ZCV9 (EMBL:AJ235272), RP599, Rickettsia prowazekii hypothetical protein (87 aa), fasta scores; E(): 0.00085, 30.7% identity in 75 aa overlap; hypothetical protein 1095875 907116 NMA1147 Neisseria meningitidis Z2491 hypothetical protein YP_002342548.1 1095627 D 122587 CDS YP_002342549.1 218768037 907117 1095987..1097270 1 NC_003116.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 1097270 gltA 907117 gltA Neisseria meningitidis Z2491 type II citrate synthase YP_002342549.1 1095987 D 122587 CDS YP_002342550.1 218768038 907118 1097475..1100303 1 NC_003116.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 1100303 sucA 907118 sucA Neisseria meningitidis Z2491 2-oxoglutarate dehydrogenase E1 YP_002342550.1 1097475 D 122587 CDS YP_002342551.1 218768039 907119 1100403..1101614 1 NC_003116.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 1101614 sucB 907119 sucB Neisseria meningitidis Z2491 dihydrolipoamide succinyltransferase YP_002342551.1 1100403 D 122587 CDS YP_002342552.1 218768040 907120 1101979..1103412 1 NC_003116.1 E3 component of 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 1103412 lpdA3 907120 lpdA3 Neisseria meningitidis Z2491 dihydrolipoamide dehydrogenase YP_002342552.1 1101979 D 122587 CDS YP_002342553.1 218768041 907121 1103507..1103794 1 NC_003116.1 NMA1152, membrane protein, len: 95 aa; unknown, contains hydrophobic, membrane-spanning regions and a N-terminal signal sequence; hypothetical protein 1103794 907121 NMA1152 Neisseria meningitidis Z2491 hypothetical protein YP_002342553.1 1103507 D 122587 CDS YP_002342554.1 218768042 907122 1103893..1105059 1 NC_003116.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1105059 sucC 907122 sucC Neisseria meningitidis Z2491 succinyl-CoA synthetase subunit beta YP_002342554.1 1103893 D 122587 CDS YP_002342555.1 218768043 907123 1105070..1105960 1 NC_003116.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 1105960 sucD 907123 sucD Neisseria meningitidis Z2491 succinyl-CoA synthetase subunit alpha YP_002342555.1 1105070 D 122587 CDS YP_002342556.1 218768044 7163867 complement(1106195..1106524) 1 NC_003116.1 NMA1155, len: 120 aa; unknown, shows similarity to parts of hypothetical proteins e.g. SW:YAFM_HAEIN (EMBL:U32706), HI0217, Haemophilus influenzae hypothetical protein (176 aa), fasta scores; E(): 2.6e-15, 42.5% identity in 106 aa overlap. Similar to parts of NMA1675,fasta scores; E(): 8.4e-07, 42.7% identity in 103 aa overlap and NMA0532, fasta scores; E(): 8.4e-07, 42.7% identity in 103 aa overlap; hypothetical protein 1106524 7163867 NMA1155 Neisseria meningitidis Z2491 hypothetical protein YP_002342556.1 1106195 R 122587 CDS YP_002342557.1 218768045 907125 1106803..1107033 1 NC_003116.1 NMA1156, len: 76 aa; unknown, lysine-rich; hypothetical protein 1107033 907125 NMA1156 Neisseria meningitidis Z2491 hypothetical protein YP_002342557.1 1106803 D 122587 CDS YP_002342558.1 218768046 907126 complement(1107199..1107996) 1 NC_003116.1 NMA1157, len: 265 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1107996 907126 NMA1157 Neisseria meningitidis Z2491 hypothetical protein YP_002342558.1 1107199 R 122587 CDS YP_002342559.1 218768047 907127 complement(1108720..1108908) 1 NC_003116.1 NMA1158, len: 62 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1108908 907127 NMA1158 Neisseria meningitidis Z2491 hypothetical protein YP_002342559.1 1108720 R 122587 CDS YP_002342560.1 218768048 907128 complement(1108965..1111811) 1 NC_003116.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1111811 uvrA 907128 uvrA Neisseria meningitidis Z2491 excinuclease ABC subunit A YP_002342560.1 1108965 R 122587 CDS YP_002342561.1 218768049 907129 1111966..1112763 1 NC_003116.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 1112763 907129 NMA1160 Neisseria meningitidis Z2491 phosphatidylserine decarboxylase YP_002342561.1 1111966 D 122587 CDS YP_002342562.1 218768050 907130 complement(1114191..1116485) 1 NC_003116.1 NMA1161, probable outer-membrane receptor protein,len: 764 aa; shows weak similarity to many outer-membrane receptors e.g. TR:O68881 (EMBL:AF055999), phuR,Pseudomonas aeruginosa outer membrane hemin receptor (764 aa), fasta scores; E(): 5.3e-09, 22.5% identity in 746 aa overlap and TR:P72121 (EMBL:D28119) Pseudomonas aeruginosa outer membrane protein C precursor (723 aa), fasta scores; E(): 0.00075, 21.0% identity in 794 aa overlap. Similar to NMA0474, fasta scores; E(): 2e-05, 20.8% identity in 795 aa overlap. Contains probable N-terminal signal sequence; outer-membrane receptor protein 1116485 907130 NMA1161 Neisseria meningitidis Z2491 outer-membrane receptor protein YP_002342562.1 1114191 R 122587 CDS YP_002342563.1 218768051 907132 1116892..1117482 1 NC_003116.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1117482 trpG 907132 trpG Neisseria meningitidis Z2491 anthranilate synthase component II YP_002342563.1 1116892 D 122587 CDS YP_002342564.1 218768052 907133 1117547..1118605 1 NC_003116.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1118605 trpD 907133 trpD Neisseria meningitidis Z2491 anthranilate phosphoribosyltransferase YP_002342564.1 1117547 D 122587 CDS YP_002342565.1 218768053 907136 1119382..1120416 1 NC_003116.1 NMA1167, phage protein, len: 344 aa; shows weak similarity to e.g. TR:O34630 (EMBL:U83796), rstA2,Vibrio cholerae bacteriophage CTXphi protein required for replication and integration (359 aa), fasta scores; E(): 1.5e-09, 27.8% identity in 223 aa overlap. Also similar to TR:O82959 (EMBL:AB015669) ORF C7 from Burkholderia solanacearum plasmid pJTPS1 (444 aa), fasta scores; E(): 1.4e-16, 33.9% identity in 239 aa overlap. Highly similar to others from Neisseria meningitidis, NMA1999, E(): 0,100.0% identity in 344 aa overlap, NMA0782, fasta scores; E(): 0, 42.7% identity in 337 aa overlap, and NMA1792,fasta scores; E(): 0, 43.3% identity in 298 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1120416 907136 NMA1167 Neisseria meningitidis Z2491 hypothetical protein YP_002342565.1 1119382 D 122587 CDS YP_002342566.1 218768054 907137 1120407..1120751 1 NC_003116.1 NMA1168, len: 114 aa; unknown, similar to others from Neisseria meningitidis, NMA2000, fasta scores; E(): 0, 100.0% identity in 114 aa overlap, NMA1793, fasta scores; E(): 1.6e-13, 37.8% identity in 98 aa overlap and NMA0781, fasta scores; E(): 2.3e-10, 34.9% identity in 83 aa overlap; hypothetical protein 1120751 907137 NMA1168 Neisseria meningitidis Z2491 hypothetical protein YP_002342566.1 1120407 D 122587 CDS YP_002342567.1 218768055 907138 1120756..1120953 1 NC_003116.1 NMA1169, len: 65 aa; unknown, similar to others from Neisseria meningitidis, NMA2001, fasta scores; E(): 4.2e-27, 100.0% identity in 65 aa overlap, NMA1794, fasta scores; E(): 4.6e-07, 38.3% identity in 60 aa overlap and NMA0780, fasta scores; E(): 1.3e-06, 36.1% identity in 61 aa overlap; hypothetical protein 1120953 907138 NMA1169 Neisseria meningitidis Z2491 hypothetical protein YP_002342567.1 1120756 D 122587 CDS YP_002342568.1 218768056 907139 1120961..1121245 1 NC_003116.1 NMA1170, integral membrane protein, len: 94 aa; unknown, similar to others from Neisseria meningitidis, NMA2002, fasta scores; E(): 0, 100.0% identity in 94 aa overlap. Contains hydrophobic, membrane-spanning regions, NMA1170, fasta scores; E(): 0,100.0% identity in 94 aa overlap and NMA0779, fasta scores; E(): 1.5e-18, 72.2% identity in 72 aa overlap; integral membrane protein 1121245 907139 NMA1170 Neisseria meningitidis Z2491 integral membrane protein YP_002342568.1 1120961 D 122587 CDS YP_002342569.1 218768057 907140 1121252..1121530 1 NC_003116.1 NMA1171, len: 92 aa; unknown, similar to others from Neisseria meningitidis, NMA2003, fasta scores; E(): 0, 100.0% identity in 92 aa overlap, NMA0778, fasta scores; (): 1.5e-25, 58.7% identity in 92 aa overlap and NMA1796, fasta scores; E(): 8.4e-09, 32.3% identity in 93 aa overlap. C-terminus is hydrophobic; hypothetical protein 1121530 907140 NMA1171 Neisseria meningitidis Z2491 hypothetical protein YP_002342569.1 1121252 D 122587 CDS YP_002342570.1 218768058 907141 1121658..1121975 1 NC_003116.1 NMA1172, len: 105 aa; similar to others from Neisseria meningitidis e.g. TR:O87782 (EMBL:AJ010115) Neisseria meningitidis strain B:15:P1.16 hypothetical protein (fragment) (148 aa), fasta scores; E(): 0, 83.8% identity in 105 aa overlap. Also similar to NMA2004, fasta scores; E(): 4e-25 54.8% identity in 104 aa overlap and NMA0777, fasta scores; E(): 6.7e-16, 57.5% identity in 73 aa overlap. Lies within a region of unusually low GC content; hypothetical protein 1121975 907141 NMA1172 Neisseria meningitidis Z2491 hypothetical protein YP_002342570.1 1121658 D 122587 CDS YP_002342571.1 218768059 907142 1121917..1122357 1 NC_003116.1 NMA1173, probable cell-surface protein, len: 146 aa; highly similar to the N-terminus of TR:O87783 (EMBL:AJ010115), tspB, Neisseria meningitidis strain B:15:P1.16 T-cell and B-cell antigen (partial CDS) (504 aa), fasta scores; E(): 5.9e-29, 68.2% identity in 129 aa overlap. Similar to others from Neisseria meningitidis,e.g. NMA0776, fasta scores; E(): 1.8e-23, 51.0% identity in 145 aa overlap, and NMA1797, fasta scores; E(): 1.8e-23, 51.0% identity in 145 aa overlap (both tspB genes) and NMA2005 (another cell-surface protein), fasta scores, E(): 1.2e-30, 66.2% identity in 133 aa overlap. N-terminal half has low GC content. Contains a probable N-terminal signal sequence; cell-surface protein 1122357 907142 NMA1173 Neisseria meningitidis Z2491 cell-surface protein YP_002342571.1 1121917 D 122587 CDS YP_002342572.1 218768060 907143 1122961..1123428 1 NC_003116.1 NMA1174, len: 155 aa; unknown, similar, except at the N-terminus, to SW:MDAB_ECOLI (EMBL:U18656), mdaB,Escherichia coli modulator of drug activity B ( modulator of topoisomerase IV activity imparting DMP 840,adriamycin and etoposide resistance on overexpression) (193 aa), fasta scores; E(): 0, 63.7% identity in 146 aa overlap. Also similar to hypothetical proteins from bacteria and Schizosaccharomyces pombe e.g. SW:YA05_SCHPO (EMBL:Z49811), SPAC5H10.05C, Schizosaccharomyces pombe hypothetical protein (196 aa), fasta scores; E(): 0, 55.1% identity in 147 aa overlap. Identical, except at the N-terminus, to NMA0600, fasta scores; E(): 0, 99.3% identity in 147 aa overlap; hypothetical protein 1123428 907143 NMA1174 Neisseria meningitidis Z2491 hypothetical protein YP_002342572.1 1122961 D 122587 CDS YP_002342573.1 218768061 907144 complement(1123636..1125021) 1 NC_003116.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1125021 pntB 907144 pntB Neisseria meningitidis Z2491 pyridine nucleotide transhydrogenase YP_002342573.1 1123636 R 122587 CDS YP_002342574.1 218768062 907145 complement(1125087..1125470) 1 NC_003116.1 NMA1176, membrane protein, len: 127 aa; unknown, contains hydrophobic, membrane-spanning regions; hypothetical protein 1125470 907145 NMA1176 Neisseria meningitidis Z2491 hypothetical protein YP_002342574.1 1125087 R 122587 CDS YP_002342575.1 218768063 907146 complement(1125474..1127015) 1 NC_003116.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1127015 pntA 907146 pntA Neisseria meningitidis Z2491 NAD(P) transhydrogenase subunit alpha YP_002342575.1 1125474 R 122587 CDS YP_002342576.1 218768064 907148 1127305..1128138 1 NC_003116.1 NMA1179, serB, probable phosphoserine phosphatase,len: 277 aa; similar, except at N-terminus, to many e.g. SW:SERB_ECOLI (EMBL:X03046), serB, Escherichia coli phosphoserine phosphatase (EC 3.1.3.3) (322 aa), fasta scores; E(): 8.4e-30, 45.7% identity in 234 aa overlap; phosphoserine phosphatase 1128138 907148 NMA1179 Neisseria meningitidis Z2491 phosphoserine phosphatase YP_002342576.1 1127305 D 122587 CDS YP_002342577.1 218768065 907151 1129591..1131183 1 NC_003116.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1131183 purH 907151 purH Neisseria meningitidis Z2491 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002342577.1 1129591 D 122587 CDS YP_002342578.1 218768066 907153 1131796..1132752 1 NC_003116.1 NMA1185, probable transposase, len: 318 aa; similar to many e.g. TR:Q51474 (EMBL:M24471) Alteromonas atlantica CDS within insertion element IS492 which is involved in reversible inactivation of extracellular polysaccharide production (318 aa), fasta scores; E(): 1.3e-28, 33.9% identity in 301 aa overlap. Also shows weak similarity to pilin-inverting genes e.g. SW:PIV_MORLA (EMBL:M34367),piv, Moraxella lacunata pilin gene inverting protein (322 aa), fasta scores; E(): 8.5e-14, 30.4% identity in 313 aa overlap. Highly similar to others from Neisseria meningitidis e.g. NMA0733, fasta scores; E(): 0, 94.3% identity in 279 aa overlap, also NMA2085. Contains Pfam match to entry PF01548 Transposase_9, Transposase; transposase 1132752 907153 NMA1185 Neisseria meningitidis Z2491 transposase YP_002342578.1 1131796 D 122587 CDS YP_002342579.1 218768067 907154 1132848..1133342 1 NC_003116.1 NMA1186, len: 164 aa; unknown, similar to part of TR:Q38494 (EMBL:M64097) bacteriophage Mu protein E16 (195 aa), fasta scores; E(): 2.7e-05, 46.7% identity in 60 aa overlap. Identical to NMA1301 and similar to NMA1867,fasta scores; E(): 1.5e-25, 55.5% identity in 137 aa overlap; hypothetical protein 1133342 907154 NMA1186 Neisseria meningitidis Z2491 hypothetical protein YP_002342579.1 1132848 D 122587 CDS YP_002342580.1 218768068 907155 1133323..1133751 1 NC_003116.1 NMA1187, len: 142 aa; unknown, identical to NMA1302 and similar to NMA1866, fasta scores; E(): 2.4e-10, 29.7% identity in 145 aa overlap; hypothetical protein 1133751 907155 NMA1187 Neisseria meningitidis Z2491 hypothetical protein YP_002342580.1 1133323 D 122587 CDS YP_002342581.1 218768069 907156 1134059..1134604 1 NC_003116.1 NMA1188, amidase, len: 181 aa; shows very weak similarity to TR:P89923 (EMBL:Y11476), ply12,Bacteriophage 12826 N-acetylmuramoyl-L-alanine amidase endolysin (EC 3.5.1.28) (257 aa), fasta scores; E(): 0.16,26.0% identity in 177 aa overlap and to bacterial amidases (some ) e.g. TR:O32421 (EMBL:D76414), lytH,Staphylococcus aureus N-acetylmuramoyl-L-alanine amidase (291 aa), fasta scores; E(): 0.0093, 25.8% identity in 182 aa overlap. Identical to NMA1303 and highly similar to NMA1865, fasta scores, E(): 0, 96.7% identity in 181 aa overlap; amidase 1134604 907156 NMA1188 Neisseria meningitidis Z2491 amidase YP_002342581.1 1134059 D 122587 CDS YP_002342582.1 218768070 907157 1134810..1134974 1 NC_003116.1 NMA1189, len: 54 aa; unknown, identical to NMA1304 and NMA1863; hypothetical protein 1134974 907157 NMA1189 Neisseria meningitidis Z2491 hypothetical protein YP_002342582.1 1134810 D 122587 CDS YP_002342583.1 218768071 907158 1134977..1135213 1 NC_003116.1 NMA1190, len: 78 aa; unknown, identical to NMA1305 and NMA1862; hypothetical protein 1135213 907158 NMA1190 Neisseria meningitidis Z2491 hypothetical protein YP_002342583.1 1134977 D 122587 CDS YP_002342584.1 218768072 907159 1135185..1135604 1 NC_003116.1 NMA1191, len: 139 aa; unknown, highly similar to NMA1306, fasta scores; E(): 0, 97.1% identity in 139 aa overlap and NMA1861, fasta scores; E(): 0, 97.1% identity in 139 aa overlap; hypothetical protein 1135604 907159 NMA1191 Neisseria meningitidis Z2491 hypothetical protein YP_002342584.1 1135185 D 122587 CDS YP_002342585.1 218768073 907160 1135624..1135806 1 NC_003116.1 NMA1192, len: 60 aa; unknown, highly similar to NMA1860, fasta scores; E(): 7.9e-26, 98.3% identity in 60 aa overlap and to part of NMA1307, fasta scores; E(): 6.8e-09, 82.8% identity in 29 aa overlap; hypothetical protein 1135806 907160 NMA1192 Neisseria meningitidis Z2491 hypothetical protein YP_002342585.1 1135624 D 122587 CDS YP_002342586.1 218768074 907161 complement(1135851..1136021) 1 NC_003116.1 NMA1193, len: 56 aa; unknown, identical to NMA1859; hypothetical protein 1136021 907161 NMA1193 Neisseria meningitidis Z2491 hypothetical protein YP_002342586.1 1135851 R 122587 CDS YP_002342587.1 218768075 907162 1136034..1136252 1 NC_003116.1 NMA1194, len: 72 aa; unknown, identical to NMA1858; hypothetical protein 1136252 907162 NMA1194 Neisseria meningitidis Z2491 hypothetical protein YP_002342587.1 1136034 D 122587 CDS YP_002342588.1 218768076 907163 1136249..1136587 1 NC_003116.1 NMA1195, len: 112 aa; unknown, highly similar to part of NMA1308, fasta scores; E(): 2e-20, 84.4% identity in 64 aa overlap and similar to part of NMA1857, fasta scores; E(): 7.2e-17, 47.3% identity in 112 aa overlap; hypothetical protein 1136587 907163 NMA1195 Neisseria meningitidis Z2491 hypothetical protein YP_002342588.1 1136249 D 122587 CDS YP_002342589.1 218768077 907164 1136599..1136865 1 NC_003116.1 NMA1196, len: 88 aa; unknown, highly similar to NMA1310, fasta scores; E(): 6.8e-34, 94.3% identity in 88 aa overlap and similar to NMA1856, fasta scores; E(): 3.5e-11, 45.2% identity in 84 aa overlap; hypothetical protein 1136865 907164 NMA1196 Neisseria meningitidis Z2491 hypothetical protein YP_002342589.1 1136599 D 122587 CDS YP_002342590.1 218768078 907165 1136862..1137059 1 NC_003116.1 NMA1197, len: 65 aa; unknown, similar to NMA1311,fasta scores; E(): 8.2e-14, 56.3% identity in 64 aa overlap and NMA1855, fasta scores; E(): 3.2e-09, 45.5% identity in 66 aa overlap; hypothetical protein 1137059 907165 NMA1197 Neisseria meningitidis Z2491 hypothetical protein YP_002342590.1 1136862 D 122587 CDS YP_002342591.1 218768079 907166 1137062..1137568 1 NC_003116.1 NMA1198, DNA-binding protein, len: 168 aa; highly similar to NMA1312, fasta scores; E(): 0, 73.7% identity in 167 aa overlap and NMA1854, fasta scores; E(): 0, 69.0% identity in 168 aa overlap. Contains probable helix-turn-helix motif at aa 21-42 (Score 1161, +3.14 SD); DNA-binding protein 1137568 907166 NMA1198 Neisseria meningitidis Z2491 DNA-binding protein YP_002342591.1 1137062 D 122587 CDS YP_002342592.1 218768080 907167 complement(1137892..1138899) 1 NC_003116.1 NMA1199, probable transposase for IS1106A3, len: 335 aa; similar to many e.g. TR:CAB44967 (EMBL:AJ242841),Neisseria meningitidis transposase for insertion sequence IS1106A3 (335 aa), fasta scores; E(): 0, 97.3% identity in 335 aa overlap; transposase for IS1106A3 1138899 907167 NMA1199 Neisseria meningitidis Z2491 transposase for IS1106A3 YP_002342592.1 1137892 R 122587 CDS YP_002342593.1 218768081 907168 complement(1139032..1140810) 1 NC_003116.1 NMA1200, probable surface fibril protein, len: 529 aa; similar to the N-terminal regions of TR:Q48152 (EMBL:U38617), hia, Haemophilus influenzae adhesin (1098 aa), fasta scores; E(): 0, 44.0% identity in 627 aa overlap and TR:P71401 (EMBL:U41852), hsf, Haemophilus influenzae type B surface fibril protein (2353 aa), fasta scores; E(): 0, 47.8% identity in 584 aa overlap; surface fibril protein 1140810 907168 NMA1200 Neisseria meningitidis Z2491 surface fibril protein YP_002342593.1 1139032 R 122587 CDS YP_002342594.1 218768082 907169 complement(1142680..1142850) 1 NC_003116.1 NMA1201, probable rubredoxin, len: 56 aa; similar to many e.g. SW:RUBR_ACICA (EMBL:Z46863) Acinetobacter calcoaceticus rubredoxin involved in the hydrocarbon hydroxylating system (54 aa), fasta scores; E(): 1.6e-13,64.2% identity in 53 aa overlap. Contains Pfam match to entry PF00301 rubredoxin, Rubredoxins and PS00202 Rubredoxin signature; rubredoxin 1142850 907169 NMA1201 Neisseria meningitidis Z2491 rubredoxin YP_002342594.1 1142680 R 122587 CDS YP_002342595.1 218768083 907170 complement(1143308..1144399) 1 NC_003116.1 NMA1202, probable acyl-CoA dehydrogenase, len: 363 aa; shows weak similarity to many e.g. SW:IVD_HUMAN (EMBL:M34192), ivd, Homo sapiens isovaleryl-CoA dehydrogenase precursor (EC 1.3.99.10) (423 aa), fasta scores; E(): 2.7e-10, 24.0% identity in 358 aa overlap. Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase; acyl-CoA dehydrogenase 1144399 907170 NMA1202 Neisseria meningitidis Z2491 acyl-CoA dehydrogenase YP_002342595.1 1143308 R 122587 CDS YP_002342596.1 218768084 907171 complement(1144534..1145082) 1 NC_003116.1 NMA1203, len: 182 aa; shows weak similarity to TR:Q53427 (EMBL:S71704), mip, Legionella pneumophila macrophage infectivity potentiator protein (184 aa), fasta scores; E(): 2.9e-08, 26.9% identity in 175 aa overlap; hypothetical protein 1145082 907171 NMA1203 Neisseria meningitidis Z2491 hypothetical protein YP_002342596.1 1144534 R 122587 CDS YP_002342597.1 218768085 907172 complement(1145237..1145608) 1 NC_003116.1 NMA1204, len: 123 aa; unknown; hypothetical protein 1145608 907172 NMA1204 Neisseria meningitidis Z2491 hypothetical protein YP_002342597.1 1145237 R 122587 CDS YP_002342598.1 218768086 907173 complement(1145903..1147594) 1 NC_003116.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 1147594 dld 907173 dld Neisseria meningitidis Z2491 D-lactate dehydrogenase YP_002342598.1 1145903 R 122587 CDS YP_002342599.1 218768087 907174 1148119..1151952 1 NC_003116.1 NMA1206, probable oxidoreductase, len: 1277 aa; the N-terminal half shows weak similarity to several oxidoreductases e.g. TR:Q9ZLW7 (EMBL:AE001480), glcD,Helicobacter pylori J99 glycolate oxidase (459 aa), fasta scores; E(): 1.5e-09, 24.8% identity in 455 aa overlap. The C-terminal half shows weak similarity to iron-sulphur proteins e.g. TR:O67558 (EMBL:AE000748), glpC, Aquifex aeolicus oxido/reductase iron sulfur protein (395 aa), fasta scores; E(): 5.2e-07,22.8% identity in 465 aa overlap. Contains Pfam matches to entry PF01565 FAD_binding_4, FAD binding domain and to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; oxidoreductase 1151952 907174 NMA1206 Neisseria meningitidis Z2491 oxidoreductase YP_002342599.1 1148119 D 122587 CDS YP_002342600.1 218768088 907175 1152029..1153030 1 NC_003116.1 NMA1207, len: 333 aa; similar to many hypothetical proteins e.g. TR:O68273 (EMBL:AF026544) Alcaligenes eutrophus hypothetical protein (322 aa), fasta scores; E(): 0, 47.3% identity in 315 aa overlap. Also similar to SW:NIR3_RHOCA (EMBL:X72382), nifR3, Rhodobacter capsulatus nitrogen regulation protein (not stringently required for nitrogen fixation) (324 aa), fasta scores; E(): 8.1e-19,31.5% identity in 324 aa overlap. Similar to NMA1633,fasta scores; E(): 8.3e-20, 34.0% identity in 244 aa overlap. Contains Pfam match to entry PF01207 UPF0034,Uncharacterized protein family UPF0034 and PS01136 Uncharacterized protein family UPF0034 signature; hypothetical protein 1153030 907175 NMA1207 Neisseria meningitidis Z2491 hypothetical protein YP_002342600.1 1152029 D 122587 CDS YP_002342601.1 218768089 907177 complement(1153921..1154013) 1 NC_003116.1 NMA1209, len: 30 aa; unknown; hypothetical protein 1154013 907177 NMA1209 Neisseria meningitidis Z2491 hypothetical protein YP_002342601.1 1153921 R 122587 CDS YP_002342602.1 218768090 907178 complement(1153976..1154284) 1 NC_003116.1 NMA1210, len: 102 aa; unknown; hypothetical protein 1154284 907178 NMA1210 Neisseria meningitidis Z2491 hypothetical protein YP_002342602.1 1153976 R 122587 CDS YP_002342603.1 218768091 907179 complement(1154336..1154851) 1 NC_003116.1 NMA1211, len: 171 aa; unknown; hypothetical protein 1154851 907179 NMA1211 Neisseria meningitidis Z2491 hypothetical protein YP_002342603.1 1154336 R 122587 CDS YP_002342604.1 218768092 907181 1155868..1155984 1 NC_003116.1 NMA1214, len: 38 aa; unknown; hypothetical protein 1155984 907181 NMA1214 Neisseria meningitidis Z2491 hypothetical protein YP_002342604.1 1155868 D 122587 CDS YP_002342605.1 218768093 907182 1155997..1156170 1 NC_003116.1 NMA1215, len: 57 aa; similar to parts of hypothetical proteins from bacteriophage and bacteria e.g. SW:YO14_BPHP1 (EMBL:U24159) bacteriophage HP1 hypothetical protein (133 aa), fasta scores; E(): 3e-07, 37.5% identity in 56 aa overlap; hypothetical protein 1156170 907182 NMA1215 Neisseria meningitidis Z2491 hypothetical protein YP_002342605.1 1155997 D 122587 CDS YP_002342606.1 218768094 907185 1156173..1156388 1 NC_003116.1 NMA1216, len: 71 aa; unknown; hypothetical protein 1156388 907185 NMA1216 Neisseria meningitidis Z2491 hypothetical protein YP_002342606.1 1156173 D 122587 CDS YP_002342607.1 218768095 907190 1156480..1157364 1 NC_003116.1 NMA1217, probable transposase for IS1106A3, len: 294 aa; highly similar to many e.g. TR:CAB44967 (EMBL:AJ242841) Neisseria meningitidis transposase for insertion sequence IS1106A3 (335 aa), fasta scores; E(): 0, 79.4% identity in 335 aa overlap. The difference in length with respect to TR:CAB44967 is accounted for by a deletion from within the C-terminal region of NMA1217; transposase for IS1106A3 1157364 907190 NMA1217 Neisseria meningitidis Z2491 transposase for IS1106A3 YP_002342607.1 1156480 D 122587 CDS YP_002342608.1 218768096 907196 complement(1158446..1159021) 1 NC_003116.1 NMA1221, phage integrase, len: 191 aa; similar to the C-terminal half of phage integrases e.g. SW:INTA_ECOLI (EMBL:U03737), intA, Escherichia coli prophage CP4-57 integrase (413 aa), fasta scores; E(): 3.1e-06, 30.3% identity in 165 aa overlap; phage integrase 1159021 907196 NMA1221 Neisseria meningitidis Z2491 phage integrase YP_002342608.1 1158446 R 122587 CDS YP_002342609.1 218768097 907197 complement(1159330..1160205) 1 NC_003116.1 NMA1222, len: 291 aa; unknown; hypothetical protein 1160205 907197 NMA1222 Neisseria meningitidis Z2491 hypothetical protein YP_002342609.1 1159330 R 122587 CDS YP_002342610.1 218768098 907198 complement(1160250..1160540) 1 NC_003116.1 NMA1223, len: 96 aa; unknown; hypothetical protein 1160540 907198 NMA1223 Neisseria meningitidis Z2491 hypothetical protein YP_002342610.1 1160250 R 122587 CDS YP_002342611.1 218768099 907200 1160845..1161222 1 NC_003116.1 NMA1225, phage repressor, len: 125 aa; shows weak similarity to SW:RPC_BPPH1 (EMBL:X02799) Bacteriophage phi-105 immunity repressor protein (144 aa),fasta scores; E(): 0.0068, 36.3% identity in 80 aa overlap and to phage repressors. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and probable helix-turn-helix motif at aa 21-42 (Score 1857, +5.51 SD). Lies within a region of unusually low GC content; phage repressor 1161222 907200 NMA1225 Neisseria meningitidis Z2491 phage repressor YP_002342611.1 1160845 D 122587 CDS YP_002342612.1 218768100 907201 1161251..1161496 1 NC_003116.1 NMA1226, len: 81 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1161496 907201 NMA1226 Neisseria meningitidis Z2491 hypothetical protein YP_002342612.1 1161251 D 122587 CDS YP_002342613.1 218768101 907202 1161582..1161674 1 NC_003116.1 NMA1227, len: 30 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1161674 907202 NMA1227 Neisseria meningitidis Z2491 hypothetical protein YP_002342613.1 1161582 D 122587 CDS YP_002342614.1 218768102 907203 1161730..1162698 1 NC_003116.1 NMA1228, len: 322 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1162698 907203 NMA1228 Neisseria meningitidis Z2491 hypothetical protein YP_002342614.1 1161730 D 122587 CDS YP_002342615.1 218768103 907204 1162695..1163177 1 NC_003116.1 NMA1229, membrane protein, len: 160 aa; unknown, contains a N-terminal signal sequence and hydrophobic, membrane-spanning regions. Lies within a region of unusually low GC content; hypothetical protein 1163177 907204 NMA1229 Neisseria meningitidis Z2491 hypothetical protein YP_002342615.1 1162695 D 122587 CDS YP_002342616.1 218768104 907205 1163267..1163770 1 NC_003116.1 NMA1230, len: 167 aa; unknown; hypothetical protein 1163770 907205 NMA1230 Neisseria meningitidis Z2491 hypothetical protein YP_002342616.1 1163267 D 122587 CDS YP_002342617.1 218768105 907208 1164210..1164620 1 NC_003116.1 NMA1233, len: 136 aa; similar to part of TR:Q50995 (EMBL:L36381) Neisseria gonorrhoeae hypothetical protein (172 aa), fasta scores; E(): 9.1e-15, 61.2% identity in 98 aa overlap; hypothetical protein 1164620 907208 NMA1233 Neisseria meningitidis Z2491 hypothetical protein YP_002342617.1 1164210 D 122587 CDS YP_002342618.1 218768106 907209 1164625..1165374 1 NC_003116.1 NMA1234, transposase, len: 249 aa; similar to many e.g. SW:T150_ECOLI (EMBL:X07037) Escherichia coli transposase for insertion sequence IS150 (283 aa), fasta scores; E(): 0, 43.7% identity in 263 aa overlap. Also highly similar to TR:Q50996 (EMBL:L36381) Neisseria gonorrhoeae hypothetical protein (267 aa), fasta scores; E(): 0, 73.4% identity in 267 aa overlap; transposase 1165374 907209 NMA1234 Neisseria meningitidis Z2491 transposase YP_002342618.1 1164625 D 122587 CDS YP_002342619.1 218768107 907210 complement(1166120..1166725) 1 NC_003116.1 NMA1237, len: 201 aa; similar to bacterial hypothetical proteins e.g. SW:YFCN_ECOLI (EMBL:AE000321),yfcN, Escherichia coli hypothetical protein (183 aa),fasta scores; E(): 3.1e-06, 27.5% identity in 178 aa overlap; hypothetical protein 1166725 907210 NMA1237 Neisseria meningitidis Z2491 hypothetical protein YP_002342619.1 1166120 R 122587 CDS YP_002342620.1 218768108 907213 complement(1169774..1170829) 1 NC_003116.1 NMA1243, probable sulphate-binding protein, len: 351 aa; similar to many e.g. SW:SUBI_ECOLI (EMBL:X02519),sbp, Escherichia coli sulfate-binding protein precursor (329 aa), fasta scores; E(): 0, 49.1% identity in 316 aa overlap. Contains Pfam match to entry PF01100 Sulphate_bind, Prokaryotic sulphate- and thiosulphate-binding protein and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; sulfate-binding protein 1170829 907213 NMA1243 Neisseria meningitidis Z2491 sulfate-binding protein YP_002342620.1 1169774 R 122587 CDS YP_002342621.1 218768109 907214 complement(1170935..1171417) 1 NC_003116.1 NMA1244, len: 160 aa; similar to TR:P72792 (EMBL:D90900) Synechocystis sp. (strain PCC 6803) hypothetical protein (160 aa), fasta scores; E(): 1.1e-05,28.8% identity in 160 aa overlap. Shows very weak similarity (not statistically significant) to eukaryotic acetyltransferases e.g. SW:ATDA_MOUSE (EMBL:L10244), sat,Mus musculus diamine acetyltransferase (EC 2.3.1.57) (171 aa), fasta scores; E(): 1, 24.8% identity in 137 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; hypothetical protein 1171417 907214 NMA1244 Neisseria meningitidis Z2491 hypothetical protein YP_002342621.1 1170935 R 122587 CDS YP_002342622.1 218768110 907215 complement(1171464..1172600) 1 NC_003116.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1172600 purK 907215 purK Neisseria meningitidis Z2491 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002342622.1 1171464 R 122587 CDS YP_002342623.1 218768111 907216 complement(1172597..1173142) 1 NC_003116.1 NMA1246, len: 181 aa; unknown, previously sequenced from Neisseria meningitidis Z2491 as TR:CAB44974 (EMBL:AJ242841). Lies within a region of unusually low GC content; hypothetical protein 1173142 907216 NMA1246 Neisseria meningitidis Z2491 hypothetical protein YP_002342623.1 1172597 R 122587 CDS YP_002342624.1 218768112 907217 complement(1173139..1174614) 1 NC_003116.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1174614 trpE 907217 trpE Neisseria meningitidis Z2491 anthranilate synthase component I YP_002342624.1 1173139 R 122587 CDS YP_002342625.1 218768113 907482 complement(1174725..1175090) 1 NC_003116.1 NMA1248, periplasmic protein, len: 121 aa; previously sequenced from Neisseria meningitidis Z2491 as TR:CAB44972 (EMBL:AJ242841). Contains N-terminal signal sequence; hypothetical protein 1175090 907482 NMA1248 Neisseria meningitidis Z2491 hypothetical protein YP_002342625.1 1174725 R 122587 CDS YP_002342626.1 218768114 907550 complement(1175111..1177021) 1 NC_003116.1 NMA1249, abcZ, probable ABC transporter ATP-binding protein, len: 636 aa; previously sequenced from Neisseria meningitidis Z2491 as TR:CAB44971 (EMBL:AJ242841). Similar to many e.g. SW:TLRC_STRFR (EMBL:M57437), tlrC,Streptomyces fradiae tylosin resistance ATP-binding protein (548 aa), blastp score; Expect = 1.5e-53 and SW:UUP_ECOLI (EMBL:AE000197), uup, Escherichia coli ABC transporter ATP-binding protein (635 aa),fasta scores; E(): 0, 47.2% identity in 634 aa overlap. . Similar to many others in Neisseria meningitidis,particularly NMA2101, fasta scores; E(): 0, 39.3% identity in 539 aa overlap. Contains two Pfam matches to entry PF00005 ABC_tran, ABC transporter, two PS00211 ABC transporters family signature and two PS00017 ATP/GTP-binding site motif A (P-loop); ABC transporter ATP-binding protein 1177021 907550 NMA1249 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002342626.1 1175111 R 122587 CDS YP_002342627.1 218768115 907554 complement(1177040..1177684) 1 NC_003116.1 NMA1250, dedA, hypothetical protein, len: 214 aa; previously sequenced from Neisseria meningitidis Z2491 as TR:CAB44970 (EMBL:AJ242841), but with a different predicted start codon. Similar to many e.g. SW:DEDA_ECOLI (EMBL:M68934), dedA, Escherichia coli dedA protein Ded A protein (219 aa), fasta scores; E(): 0, 68.0% identity in 206 aa overlap. Contains Pfam match to entry PF00597 DedA,DedA family; DedA protein NMB_orthologue 1177684 907554 NMA1250 Neisseria meningitidis Z2491 DedA protein NMB_orthologue YP_002342627.1 1177040 R 122587 CDS YP_002342628.1 218768116 907555 complement(1177848..1178666) 1 NC_003116.1 NMA1251, opcA, outer membrane protein precursor,len: 272 aa; previously sequenced from Neisseria meningitidis Z2491 as TR:CAB44969 (EMBL:AJ242841). C-terminus is similar to NMA2183, fasta scores; E(): 1e-05, 29.2% identity in 89 aa overlap. Contains an N-terminal signal sequence; outer membrane protein 1178666 907555 NMA1251 Neisseria meningitidis Z2491 outer membrane protein YP_002342628.1 1177848 R 122587 CDS YP_002342629.1 218768117 907557 1179979..1180986 1 NC_003116.1 NMA1253, probable transposase for IS1106A3, len: 335 aa; previously sequenced as TR:CAB44967 (EMBL:AJ242841); transposase for IS1106A3 1180986 907557 NMA1253 Neisseria meningitidis Z2491 transposase for IS1106A3 YP_002342629.1 1179979 D 122587 CDS YP_002342630.1 218768118 907570 complement(1181711..1182961) 1 NC_003116.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1182961 glyA 907570 glyA Neisseria meningitidis Z2491 serine hydroxymethyltransferase YP_002342630.1 1181711 R 122587 CDS YP_002342631.1 218768119 907578 complement(1183442..1185217) 1 NC_003116.1 NMA1255, ggt, probable gamma-glutamyltranspeptidase, len: 591 aa; similar to many e.g. SW:GGT_BACSU (EMBL:U49358), ggt, Bacillus subtilis gamma-glutamyltranspeptidase precursor (EC 2.3.2.2) (587 aa), fasta scores; E(): 0, 38.2% identity in 573 aa overlap. Contains Pfam match to entry PF01019 G_glu_transpept, Gamma-glutamyltranspeptidase and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; gamma-glutamyltranspeptidase 1185217 907578 NMA1255 Neisseria meningitidis Z2491 gamma-glutamyltranspeptidase YP_002342631.1 1183442 R 122587 CDS YP_002342632.1 218768120 907584 1185786..1186013 1 NC_003116.1 NMA1257, len: 75 aa; unknown; hypothetical protein 1186013 907584 NMA1257 Neisseria meningitidis Z2491 hypothetical protein YP_002342632.1 1185786 D 122587 CDS YP_002342633.1 218768121 907596 1185989..1186207 1 NC_003116.1 NMA1258, len: 72 aa; similar to hypothetical proteins TR:Q9ZJY4 (EMBL:AE001544) Helicobacter pylori J99 hypothetical protein (76 aa), fasta scores; E(): 1.1e-06,47.0% identity in 66 aa overlap and TR:O25839 (EMBL:AE000629) Helicobacter pylori 26695 hypothetical protein (76 aa), fasta scores; E(): 1.3e-06, 45.5% identity in 66 aa overlap; hypothetical protein 1186207 907596 NMA1258 Neisseria meningitidis Z2491 hypothetical protein YP_002342633.1 1185989 D 122587 CDS YP_002342634.1 218768122 907597 complement(1186366..1187340) 1 NC_003116.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 1187340 fbp 907597 fbp Neisseria meningitidis Z2491 fructose-1,6-bisphosphatase YP_002342634.1 1186366 R 122587 CDS YP_002342635.1 218768123 907675 complement(1187586..1188431) 1 NC_003116.1 NMA1260, len: 281 aa; unknown, similar to SW:YHIR_ECOLI (EMBL:U00039), yhiR, Escherichia coli hypothetical protein (280 aa), fasta scores; E(): 0, 42.3% identity in 274 aa overlap and SW:YHIR_HAEIN (EMBL:M62809), HI0441, Haemophilus influenzae hypothetical protein (281 aa), fasta scores; E(): 0, 41.9% identity in 272 aa overlap; hypothetical protein 1188431 907675 NMA1260 Neisseria meningitidis Z2491 hypothetical protein YP_002342635.1 1187586 R 122587 CDS YP_002342636.1 218768124 907676 complement(1188519..1189121) 1 NC_003116.1 NMA1261, integral membrane protein, len: 200 aa; similar to many bacterial hypothetical proteins e.g. SW:YGIH_ECOLI (EMBL:U28379), ygiH, Escherichia coli hypothetical protein (205 aa), fasta scores; E(): 7.8e-26,43.5% identity in 193 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein 1189121 907676 NMA1261 Neisseria meningitidis Z2491 integral membrane protein YP_002342636.1 1188519 R 122587 CDS YP_002342637.1 218768125 907677 1189177..1189533 1 NC_003116.1 NMA1262, folB, probable dihydroneopterin aldolase,len: 118 aa; similar to many e.g. SW:FOLB_BACSU (EMBL:M34053), folB, Bacillus subtilis dihydroneopterin aldolase (EC 4.1.2.25) (120 aa), fasta scores; E(): 3.5e-07, 35.3% identity in 119 aa overlap and SW:FOLB_ECOLI (EMBL:U28379), folB, Escherichia coli probable dihydroneopterin aldolase (122 aa), fasta scores; E(): 9.2e-15, 40.0% identity in 115 aa overlap; dihydroneopterin aldolase 1189533 907677 NMA1262 Neisseria meningitidis Z2491 dihydroneopterin aldolase YP_002342637.1 1189177 D 122587 CDS YP_002342638.1 218768126 907678 1189567..1190103 1 NC_003116.1 NMA1263, len: 178 aa; unknown, similar to many bacterial hypothetical proteins e.g. SW:YQKG_BACSU (EMBL:D84432), yqkG, Bacillus subtilis hypothetical protein (185 aa), fasta scores; E(): 6.9e-21, 37.9% identity in 177 aa overlap. Contains Pfam match to entry PF00293 mutT, Bacterial mutT protein; hypothetical protein 1190103 907678 NMA1263 Neisseria meningitidis Z2491 hypothetical protein YP_002342638.1 1189567 D 122587 CDS YP_002342639.1 218768127 907679 complement(1190759..1191118) 1 NC_003116.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1191118 907679 NMA1264 Neisseria meningitidis Z2491 camphor resistance protein CrcB YP_002342639.1 1190759 R 122587 CDS YP_002342640.1 218768128 907680 complement(1191147..1191827) 1 NC_003116.1 NMA1265, probable integral membrane protein, len: 226 aa; unknown, contains hydrophobic, probable membrane-spanning regions; integral membrane protein 1191827 907680 NMA1265 Neisseria meningitidis Z2491 integral membrane protein YP_002342640.1 1191147 R 122587 CDS YP_002342641.1 218768129 907681 1191992..1195036 1 NC_003116.1 NMA1266, cell-division protein, len: 1014 aa; similar to many e.g. SW:FTSK_ECOLI (EMBL:Z49932),ftsK, Escherichia coli cell division protein (1329 aa),fasta scores; E(): 0, 40.0% identity in 1015 aa overlap,the E.coli protein being approx. 300 aa longer at the N-terminus. Note that this means most of the predicted membrane spans in the E.coli homologue are absent from this protein. Similar over the C-terminal approx. 500 aa to NMA1527, fasta scores; E(): 0, 57.9% identity in 556 aa overlap. Contains Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family and PS00017 ATP/GTP-binding site motif A (P-loop). Contains a probable N-terminal signal sequence and a hydrophobic, probable membrane-spanning region; cell-division protein 1195036 907681 NMA1266 Neisseria meningitidis Z2491 cell-division protein YP_002342641.1 1191992 D 122587 CDS YP_002342642.1 218768130 907682 complement(1195261..1196523) 1 NC_003116.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 1196523 proA 907682 proA Neisseria meningitidis Z2491 gamma-glutamyl phosphate reductase YP_002342642.1 1195261 R 122587 CDS YP_002342643.1 218768131 907683 complement(1196536..1197645) 1 NC_003116.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1197645 proB 907683 proB Neisseria meningitidis Z2491 gamma-glutamyl kinase YP_002342643.1 1196536 R 122587 CDS YP_002342644.1 218768132 907684 1198131..1199684 1 NC_003116.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 1199684 leuA 907684 leuA Neisseria meningitidis Z2491 2-isopropylmalate synthase YP_002342644.1 1198131 D 122587 CDS YP_002342645.1 218768133 907685 1199884..1200546 1 NC_003116.1 NMA1272, len: 220 aa; unknown, shows weak similarity to SW:YECA_ECOLI (EMBL:AE000284), yecA,Escherichia coli hypothetical protein (221 aa), fasta scores; E(): 5.5e-12, 27.2% identity in 228 aa overlap; hypothetical protein 1200546 907685 NMA1272 Neisseria meningitidis Z2491 hypothetical protein YP_002342645.1 1199884 D 122587 CDS YP_002342646.1 218768134 907686 complement(1200629..1201480) 1 NC_003116.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1201480 lgt 907686 lgt Neisseria meningitidis Z2491 prolipoprotein diacylglyceryl transferase YP_002342646.1 1200629 R 122587 CDS YP_002342647.1 218768135 907687 complement(1201551..1202681) 1 NC_003116.1 NMA1274, len: 376 aa; unknown, similar to SW:YPG2_ZYMMO (EMBL:L09649), zm2, Zymomonas mobilis hypothetical protein (380 aa), fasta scores; E(): 0, 47.1% identity in 374 aa overlap. Also similar to parts of Caenorhabditis elegans hypothetical proteins e.g. TR:O76373 (EMBL:AF067618), F56H1.5, Caenorhabditis elegans hypothetical protein (1192 aa), fasta scores; E(): 5e-11,27.1% identity in 317 aa overlap. Contains Pfam match to entry PF00246 Zn_carbOpept, Zinc carboxypeptidase; hypothetical protein 1202681 907687 NMA1274 Neisseria meningitidis Z2491 hypothetical protein YP_002342647.1 1201551 R 122587 CDS YP_002342648.1 218768136 907688 1202851..1203747 1 NC_003116.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1203747 argB 907688 argB Neisseria meningitidis Z2491 acetylglutamate kinase YP_002342648.1 1202851 D 122587 CDS YP_002342649.1 218768137 907690 complement(1205184..1205852) 1 NC_003116.1 NMA1278, len: 222 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:O33611 (EMBL:AB004855) Streptomyces cyaneus protein possibly involved in morphological differentiation (277 aa), fasta scores; E(): 1.5e-15, 29.1% identity in 227 aa overlap and TR:O69629 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical protein (287 aa), fasta scores; E(): 2.1e-15, 30.2% identity in 222 aa overlap; hypothetical protein 1205852 907690 NMA1278 Neisseria meningitidis Z2491 hypothetical protein YP_002342649.1 1205184 R 122587 CDS YP_002342650.1 218768138 907691 complement(1205849..1206580) 1 NC_003116.1 NMA1279, len: 243 aa; similar to SW:YFGE_ECOLI (EMBL:AE000336), yfgE, Escherichia coli hypothetical protein (248 aa), fasta scores; E(): 3.2e-19, 31.3% identity in 230 aa overlap and SW:YFGE_HAEIN (EMBL:U32802), HI1225.1, Haemophilus influenzae hypothetical protein (231 aa), fasta scores; E(): 5.8e-17,30.1% identity in 226 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop), which may be fortuitous; DnaA regulatory inactivator Hda 1206580 907691 NMA1279 Neisseria meningitidis Z2491 DnaA regulatory inactivator Hda YP_002342650.1 1205849 R 122587 CDS YP_002342651.1 218768139 907693 1207416..1207601 1 NC_003116.1 NMA1281, len: 61 aa; unknown; hypothetical protein 1207601 907693 NMA1281 Neisseria meningitidis Z2491 hypothetical protein YP_002342651.1 1207416 D 122587 CDS YP_002342652.1 218768140 907694 complement(1207797..1208678) 1 NC_003116.1 NMA1282, DNA-binding protein, len: 293 aa; unknown, contains probable helix-turn-helix at aa 42-63 (Score 1152, +3.11 SD); DNA-binding protein 1208678 907694 NMA1282 Neisseria meningitidis Z2491 DNA-binding protein YP_002342652.1 1207797 R 122587 CDS YP_002342653.1 218768141 907695 1208726..1208977 1 NC_003116.1 NMA1283, len: 83 aa; unknown; hypothetical protein 1208977 907695 NMA1283 Neisseria meningitidis Z2491 hypothetical protein YP_002342653.1 1208726 D 122587 CDS YP_002342654.1 218768142 907696 1208979..1210952 1 NC_003116.1 NMA1284, phage transposase, len: 657 aa; similar to TR:Q38013 (EMBL:X87627) Bacteriophage D3112 transposase A (690 aa), fasta scores; E(): 0, 34.0% identity in 623 aa overlap. Similar to NMA1882, fasta scores; E(): 0, 41.3% identity in 656 aa overlap. Contains Pfam match to entry PF00552 integrase, Integrase and PS00017 ATP/GTP-binding site motif A (P-loop); phage transposase 1210952 907696 NMA1284 Neisseria meningitidis Z2491 phage transposase YP_002342654.1 1208979 D 122587 CDS YP_002342655.1 218768143 907699 1212171..1212437 1 NC_003116.1 NMA1287, len: 88 aa; unknown, similar to part of NMA1880, fasta scores; E(): 0.0086, 36.5% identity in 63 aa overlap; hypothetical protein 1212437 907699 NMA1287 Neisseria meningitidis Z2491 hypothetical protein YP_002342655.1 1212171 D 122587 CDS YP_002342656.1 218768144 907701 1212430..1212549 1 NC_003116.1 NMA1288, len: 39 aa; unknown; hypothetical protein 1212549 907701 NMA1288 Neisseria meningitidis Z2491 hypothetical protein YP_002342656.1 1212430 D 122587 CDS YP_002342657.1 218768145 907702 1212698..1212820 1 NC_003116.1 NMA1289, len: 40 aa; unknown; hypothetical protein 1212820 907702 NMA1289 Neisseria meningitidis Z2491 hypothetical protein YP_002342657.1 1212698 D 122587 CDS YP_002342658.1 218768146 907703 1212900..1213067 1 NC_003116.1 NMA1290, len: 55 aa; unknown; hypothetical protein 1213067 907703 NMA1290 Neisseria meningitidis Z2491 hypothetical protein YP_002342658.1 1212900 D 122587 CDS YP_002342659.1 218768147 907704 1213177..1213695 1 NC_003116.1 NMA1291, gam, probable host-nuclease inhibitor protein, len: 172 aa; similar to several e.g. SW:VGAM_BPMU (EMBL:X04390), gam, Bacteriophage Mu host-nuclease inhibitor protein (174 aa), fasta scores; E(): 3.9e-24,46.8% identity in 173 aa overlap; host-nuclease inhibitor protein 1213695 907704 NMA1291 Neisseria meningitidis Z2491 host-nuclease inhibitor protein YP_002342659.1 1213177 D 122587 CDS YP_002342660.1 218768148 907705 complement(1213855..1214070) 1 NC_003116.1 NMA1292, len: 71 aa; unknown; hypothetical protein 1214070 907705 NMA1292 Neisseria meningitidis Z2491 hypothetical protein YP_002342660.1 1213855 R 122587 CDS YP_002342661.1 218768149 907706 complement(1214074..1214682) 1 NC_003116.1 NMA1293, phage anti-repressor protein,len: 202 aa; similar to several e.g. TR:Q38585 (EMBL:X95646), ant, Streptococcus thermophilus bacteriophage Sfi21 anti-repressor protein (287 aa), fasta scores; E(): 6.5e-07, 31.3% identity in 134 aa overlap and TR:AAD25485 (EMBL:AF125520), L0142, bacteriophage 933W hypothetical protein (209 aa), fasta scores; E(): 2.7e-17,37.8% identity in 201 aa overlap; phage anti-repressor protein 1214682 907706 NMA1293 Neisseria meningitidis Z2491 phage anti-repressor protein YP_002342661.1 1214074 R 122587 CDS YP_002342662.1 218768150 907707 complement(1214814..1215014) 1 NC_003116.1 NMA1294, len: 66 aa; unknown, similar to NMA1297,fasta scores; E(): 1.4e-08, 43.9% identity in 57 aa overlap and NMA1295, fasta scores; E(): 7.1e-07, 51.1% identity in 47 aa overlap; hypothetical protein 1215014 907707 NMA1294 Neisseria meningitidis Z2491 hypothetical protein YP_002342662.1 1214814 R 122587 CDS YP_002342663.1 218768151 907708 complement(1215215..1215400) 1 NC_003116.1 NMA1295, len: 61 aa; unknown, similar to NMA1297,fasta scores; E(): 2.7e-09, 53.8% identity in 52 aa overlap and NMA1294, fasta scores; E(): 4.1e-06, 51.1% identity in 47 aa overlap; hypothetical protein 1215400 907708 NMA1295 Neisseria meningitidis Z2491 hypothetical protein YP_002342663.1 1215215 R 122587 CDS YP_002342664.1 218768152 907709 complement(1215379..1215480) 1 NC_003116.1 NMA1296, len: 33 aa; unknown; hypothetical protein 1215480 907709 NMA1296 Neisseria meningitidis Z2491 hypothetical protein YP_002342664.1 1215379 R 122587 CDS YP_002342665.1 218768153 907710 complement(1215673..1215840) 1 NC_003116.1 NMA1297, len: 55 aa; unknown, similar to NMA1295,fasta scores; E(): 1.9e-10, 53.8% identity in 52 aa overlap and NMA1294, fasta scores; E(): 1.1e-08, 43.9% identity in 57 aa overlap; hypothetical protein 1215840 907710 NMA1297 Neisseria meningitidis Z2491 hypothetical protein YP_002342665.1 1215673 R 122587 CDS YP_002342666.1 218768154 907711 1216064..1216246 1 NC_003116.1 NMA1298, len: 60 aa; unknown; hypothetical protein 1216246 907711 NMA1298 Neisseria meningitidis Z2491 hypothetical protein YP_002342666.1 1216064 D 122587 CDS YP_002342667.1 218768155 907712 1216363..1216554 1 NC_003116.1 NMA1299, len: 63 aa; unknown; hypothetical protein 1216554 907712 NMA1299 Neisseria meningitidis Z2491 hypothetical protein YP_002342667.1 1216363 D 122587 CDS YP_002342668.1 218768156 907713 1216551..1216967 1 NC_003116.1 NMA1300, membrane protein, len: 138 aa; unknown, contains hydrophobic, membrane-spanning regions; hypothetical protein 1216967 907713 NMA1300 Neisseria meningitidis Z2491 hypothetical protein YP_002342668.1 1216551 D 122587 CDS YP_002342669.1 218768157 907714 1217082..1217576 1 NC_003116.1 NMA1301, len: 164 aa; unknown, similar to part of TR:Q38494 (EMBL:M64097) bacteriophage Mu protein E16 (195 aa), fasta scores; E(): 2.7e-05, 46.7% identity in 60 aa overlap. Identical to NMA1186 and similar to NMA1867,fasta scores; E(): 1.5e-25, 55.5% identity in 137 aa overlap; hypothetical protein 1217576 907714 NMA1301 Neisseria meningitidis Z2491 hypothetical protein YP_002342669.1 1217082 D 122587 CDS YP_002342670.1 218768158 907715 1217557..1217985 1 NC_003116.1 NMA1302, len: 142 aa; unknown, identical to NMA1187 and similar to NMA1866, fasta scores; E(): 1.8e-10, 29.7% identity in 145 aa overlap; hypothetical protein 1217985 907715 NMA1302 Neisseria meningitidis Z2491 hypothetical protein YP_002342670.1 1217557 D 122587 CDS YP_002342671.1 218768159 907716 1218293..1218838 1 NC_003116.1 NMA1303, amidase, len: 181 aa; shows very weak similarity to TR:P89923 (EMBL:Y11476), ply12,Bacteriophage 12826 N-acetylmuramoyl-L-alanine amidase endolysin (EC 3.5.1.28) (257 aa), fasta scores; E(): 0.16,26.0% identity in 177 aa overlap and to bacterial amidases (some ) e.g. TR:O32421 (EMBL:D76414), lytH,Staphylococcus aureus N-acetylmuramoyl-L-alanine amidase (291 aa), fasta scores; E(): 0.0093, 25.8% identity in 182 aa overlap. identical to NMA1188 and highly similar to NMA1864, fasta scores; E(): 0, 96.7% identity in 181 aa overlap; amidase 1218838 907716 NMA1303 Neisseria meningitidis Z2491 amidase YP_002342671.1 1218293 D 122587 CDS YP_002342672.1 218768160 907717 1219044..1219208 1 NC_003116.1 NMA1304, len: 54 aa; unknown, identical to NMA1189 and NMA1863; hypothetical protein 1219208 907717 NMA1304 Neisseria meningitidis Z2491 hypothetical protein YP_002342672.1 1219044 D 122587 CDS YP_002342673.1 218768161 907718 1219211..1219447 1 NC_003116.1 NMA1305, len: 78 aa; unknown, identical to NMA1190 and NMA1862; hypothetical protein 1219447 907718 NMA1305 Neisseria meningitidis Z2491 hypothetical protein YP_002342673.1 1219211 D 122587 CDS YP_002342674.1 218768162 907719 1219419..1219838 1 NC_003116.1 NMA1306, len: 139 aa; unknown, identical to NMA1861 and highly similar to NMA1191, fasta scores; E(): 0, 97.1% identity in 139 aa overlap; hypothetical protein 1219838 907719 NMA1306 Neisseria meningitidis Z2491 hypothetical protein YP_002342674.1 1219419 D 122587 CDS YP_002342675.1 218768163 907720 1219858..1220052 1 NC_003116.1 NMA1307, len: 64 aa; unknown, highly similar to NMA1192, fasta scores; E(): 1.9e-11, 82.8% identity in 29 aa overlap and NMA1860, fasta scores; E(): 1.9e-11, 82.8% identity in 29 aa overlap; hypothetical protein 1220052 907720 NMA1307 Neisseria meningitidis Z2491 hypothetical protein YP_002342675.1 1219858 D 122587 CDS YP_002342676.1 218768164 907721 1220049..1220261 1 NC_003116.1 NMA1308, len: 70 aa; unknown, highly similar to NMA1195, fasta scores; E(): 3.3e-24, 84.4% identity in 64 aa overlap and NMA1157, fasta scores; E(): 1.7e-11, 47.5% identity in 61 aa overlap; hypothetical protein 1220261 907721 NMA1308 Neisseria meningitidis Z2491 hypothetical protein YP_002342676.1 1220049 D 122587 CDS YP_002342677.1 218768165 907722 1220258..1220377 1 NC_003116.1 NMA1309, len: 39 aa; unknown, similar to NMA1195,fasta scores; E(): 6.1e-08, 65.7% identity in 35 aa overlap and NMA1857, fasta scores; E(): 0.036, 42.9% identity in 35 aa overlap; hypothetical protein 1220377 907722 NMA1309 Neisseria meningitidis Z2491 hypothetical protein YP_002342677.1 1220258 D 122587 CDS YP_002342678.1 218768166 907723 1220389..1220655 1 NC_003116.1 NMA1310, len: 88 aa; unknown, highly similar to NMA1196, fasta scores; E(): 3.9e-33, 94.3% identity in 88 aa overlap and similar to NMA1156, fasta scores; E(): 1.5e-10, 44.0% identity in 84 aa overlap; hypothetical protein 1220655 907723 NMA1310 Neisseria meningitidis Z2491 hypothetical protein YP_002342678.1 1220389 D 122587 CDS YP_002342679.1 218768167 907724 1220652..1220849 1 NC_003116.1 NMA1311, len: 65 aa; unknown, similar to NMA1197,fasta scores; E(): 1.1e-14, 56.3% identity in 64 aa overlap and NMA1855, fasta scores; E(): 1.2e-10, 47.0% identity in 66 aa overlap; hypothetical protein 1220849 907724 NMA1311 Neisseria meningitidis Z2491 hypothetical protein YP_002342679.1 1220652 D 122587 CDS YP_002342680.1 218768168 907725 1220851..1221357 1 NC_003116.1 NMA1312, DNA-binding protein, len: 168 aa; unknown, similar to NMA1198, fasta scores; E(): 0, 73.7% identity in 167 aa overlap and NMA1854, fasta scores; E(): 0, 56.3% identity in 167 aa overlap. Contains probable helix-turn-helix motif at aa 21-42 (Score 1051, +2.77 SD); DNA-binding protein 1221357 907725 NMA1312 Neisseria meningitidis Z2491 DNA-binding protein YP_002342680.1 1220851 D 122587 CDS YP_002342681.1 218768169 907726 1221378..1223000 1 NC_003116.1 NMA1313, len: 540 aa; unknown, highly similar to NMA1852, fasta scores; E(): 0, 86.5% identity in 539 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1223000 907726 NMA1313 Neisseria meningitidis Z2491 hypothetical protein YP_002342681.1 1221378 D 122587 CDS YP_002342682.1 218768170 907727 1223000..1224568 1 NC_003116.1 NMA1314, len: 522 aa; unknown, similar to SW:YF01_HAEIN (EMBL:U32826), HI1501, Haemophilus influenzae hypothetical protein (520 aa), fasta scores; E(): 0, 40.2% identity in 518 aa overlap and contains a region similar to SW:YF71_HAEIN (EMBL:U32831), HI1571,Haemophilus influenzae hypothetical protein (79 aa), fasta scores; E(): 7.5e-14, 63.2% identity in 76 aa overlap. Highly similar to NMA1851, fasta scores; E(): 0, 49.0% identity in 510 aa overlap; hypothetical protein 1224568 907727 NMA1314 Neisseria meningitidis Z2491 hypothetical protein YP_002342682.1 1223000 D 122587 CDS YP_002342683.1 218768171 907728 1224555..1225850 1 NC_003116.1 NMA1315, len: 431 aa; unknown, contains regions similar to SW:YF70_HAEIN (EMBL:U32831), HI1570,Haemophilus influenzae hypothetical protein (169 aa),fasta scores; E(): 4.6e-25, 48.7% identity in 154 aa overlap, SW:YF02_HAEIN (EMBL:U32827), HI1502, Haemophilus influenzae hypothetical protein (414 aa), fasta scores; E(): 3.8e-22, 35.4% identity in 237 aa overlap and TR:Q46548 (EMBL:U20249) Bacteroides nodosus plasmid pJIR787 ORF240' (fragment) (240 aa), fasta scores; E(): 4.8e-12, 30.4% identity in 194 aa overlap. Similar to NMA1850, fasta scores; E(): 0, 33.1% identity in 378 aa overlap; hypothetical protein 1225850 907728 NMA1315 Neisseria meningitidis Z2491 hypothetical protein YP_002342683.1 1224555 D 122587 CDS YP_002342684.1 218768172 907732 1228229..1229374 1 NC_003116.1 NMA1320, len: 381 aa; unknown, shows weak similarity to SW:VPP_BPMU (EMBL:X06796) bacteriophage Mu tail protein (379 aa), fasta scores; E(): 1.2e-12, 24.9% identity in 366 aa overlap. Similar to NMA1830, fasta scores; E(): 0, 44.8% identity in 373 aa overlap; hypothetical protein 1229374 907732 NMA1320 Neisseria meningitidis Z2491 hypothetical protein YP_002342684.1 1228229 D 122587 CDS YP_002342685.1 218768173 907733 1229371..1230039 1 NC_003116.1 NMA1321, len: 222 aa; unknown, shows weak similarity to SW:VPV_BPP2 (EMBL:AF063097) bacteriophage P2 baseplate assembly protein V (211 aa), fasta scores; E(): 0.85, 24.4% identity in 221 aa overlap and SW:YF18_HAEIN (EMBL:U32827), HI1518, Haemophilus influenzae hypothetical protein (182 aa), fasta scores; E(): 0.0011, 26.8% identity in 194 aa overlap. Similar to NMA1829, fasta scores; E(): 1.8e-32, 46.7% identity in 197 aa overlap; hypothetical protein 1230039 907733 NMA1321 Neisseria meningitidis Z2491 hypothetical protein YP_002342685.1 1229371 D 122587 CDS YP_002342686.1 218768174 907734 1230139..1230486 1 NC_003116.1 NMA1322, len: 115 aa; unknown, shows weak similarity to SW:YF19_HAEIN (EMBL:U32827), HI1519,Haemophilus influenzae hypothetical protein (135 aa),fasta scores; E(): 0.031, 36.3% identity in 102 aa overlap. Similar to NMA1828, fasta scores; E(): 3.4e-20,51.3% identity in 117 aa overlap; hypothetical protein 1230486 907734 NMA1322 Neisseria meningitidis Z2491 hypothetical protein YP_002342686.1 1230139 D 122587 CDS YP_002342687.1 218768175 907735 1230500..1231555 1 NC_003116.1 NMA1323, len: 351 aa; unknown, similar to bacterial hypothetical proteins including SW:XKDT_BACSU (EMBL:Z70177), xkdT, phage-like element PbsX protein (348 aa), fasta scores; E(): 1.2e-07, 28.0% identity in 361 aa overlap and SW:YF20_HAEIN (EMBL:U32827), HI1520,Haemophilus influenzae hypothetical protein (355 aa),fasta scores; E(): 4.7e-16, 31.5% identity in 321 aa overlap. Similar at the N-terminus to NMA1827, fasta scores; E(): 1.5e-18, 41.4% identity in 152 aa overlap and at the C-terminus to NMA1826, fasta scores; E(): 1e-29,50.8% identity in 185 aa overlap; hypothetical protein 1231555 907735 NMA1323 Neisseria meningitidis Z2491 hypothetical protein YP_002342687.1 1230500 D 122587 CDS YP_002342688.1 218768176 907736 1231552..1232112 1 NC_003116.1 NMA1324, len: 186 aa; unknown, shows weak similarity to SW:YMFQ_ECOLI (EMBL:AE000214), ymfQ,Escherichia coli hypothetical protein (194 aa), fasta scores; E(): 0.0001, 28.2% identity in 195 aa overlap. Similar to NMA1825, fasta scores; E(): 9.6e-24, 42.4% identity in 184 aa overlap; hypothetical protein 1232112 907736 NMA1324 Neisseria meningitidis Z2491 hypothetical protein YP_002342688.1 1231552 D 122587 CDS YP_002342689.1 218768177 907737 1232123..1234096 1 NC_003116.1 NMA1325, phage tail fibre protein, len: 657 aa; similar in part to SW:VPH_BPHP1 (EMBL:U24159) bacteriophage HP1 probable tail fibre protein (925 aa),fasta scores; E(): 0, 48.7% identity in 452 aa overlap. The N-terminus is similar to that of NMA1824, fasta scores; E(): 3.9e-09, 33.3% identity in 147 aa overlap; phage tail fiber protein 1234096 907737 NMA1325 Neisseria meningitidis Z2491 phage tail fiber protein YP_002342689.1 1232123 D 122587 CDS YP_002342690.1 218768178 907740 1235174..1235779 1 NC_003116.1 NMA1328, len: 201 aa; unknown, C-terminal half is similar to SW:YE02_HAEIN (EMBL:U32820), HI1402,Haemophilus influenzae hypothetical protein (68 aa), fasta scores; E(): 1.3e-08, 56.3% identity in 64 aa overlap. Shows weak similarity to NMA1823, E(): 3.6e-07, 28.8% identity in 191 aa overlap; hypothetical protein 1235779 907740 NMA1328 Neisseria meningitidis Z2491 hypothetical protein YP_002342690.1 1235174 D 122587 CDS YP_002342691.1 218768179 907741 1235758..1236054 1 NC_003116.1 NMA1329, len: 98 aa; unknown; hypothetical protein 1236054 907741 NMA1329 Neisseria meningitidis Z2491 hypothetical protein YP_002342691.1 1235758 D 122587 CDS YP_002342692.1 218768180 907744 complement(1237954..1238601) 1 NC_003116.1 NMA1332, periplasmic protein, len: 215 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein 1238601 907744 NMA1332 Neisseria meningitidis Z2491 hypothetical protein YP_002342692.1 1237954 R 122587 CDS YP_002342693.1 218768181 907745 complement(1238598..1238969) 1 NC_003116.1 NMA1334, periplasmic protein, len: 123 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein 1238969 907745 NMA1334 Neisseria meningitidis Z2491 hypothetical protein YP_002342693.1 1238598 R 122587 CDS YP_002342694.1 218768182 907746 complement(1238976..1239647) 1 NC_003116.1 NMA1335, periplasmic protein, len: 223 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein 1239647 907746 NMA1335 Neisseria meningitidis Z2491 hypothetical protein YP_002342694.1 1238976 R 122587 CDS YP_002342695.1 218768183 907747 complement(1239812..1240582) 1 NC_003116.1 NMA1336, oxidoreductase, len: 256 aa; similar to many from both bacterial and eukaryotic sources e.g. weak similarity to SW:TRN1_DATST (EMBL:L20473) Datura stramonium tropinone reductase-I (273 aa), fasta scores; E(): 7.1e-11, 30.2% identity in 205 aa overlap. Similar to SW:YCIK_ECOLI (EMBL:AE000225), yciK, Escherichia coli hypothetical oxidoreductase (252 aa), fasta scores; E(): 6.9e-25, 35.2% identity in 233 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase; short chain dehydrogenase 1240582 907747 NMA1336 Neisseria meningitidis Z2491 short chain dehydrogenase YP_002342695.1 1239812 R 122587 CDS YP_002342696.1 218768184 907748 complement(1240615..1241928) 1 NC_003116.1 NMA1338, oxidoreductase, len: 437 aa; shows weak similarity to phytoene dehydrogenases e.g. TR:Q40406 (EMBL:X78815), pds, Narcissus pseudonarcissus phytoene dehydrogenase precursor (570 aa), fasta scores; E(): 1.6e-06, 24.7% identity in 473 aa overlap. Also to SW:Y4AB_RHISN (EMBL:AE000064), Y4AB, Rhizobium sp. (strain NGR234) hypothetical protein (417 aa), fasta scores; E(): 8.9e-15, 27.3% identity in 444 aa overlap; oxidoreductase 1241928 907748 NMA1338 Neisseria meningitidis Z2491 oxidoreductase YP_002342696.1 1240615 R 122587 CDS YP_002342697.1 218768185 907749 complement(1242009..1242881) 1 NC_003116.1 NMA1339, poly-isoprenyl transferase, len: 290 aa; similar to many phytoene synthases e.g. SW:PSY_CAPAN (EMBL:X68017), psy1, Capsicum annuum phytoene synthase precursor (EC 2.5.1.-) (419 aa), fasta scores; E(): 6.7e-26, 36.0% identity in 278 aa overlap (NMA1339 is shorter at the N-terminus) and TR:CAB39693 (EMBL:AL049485), SC6A5.09, Streptomyces coelicolor phytoene synthase (312 aa0, fasta scores; E(): 1.6e-32, 38.0% identity in 287 aa overlap. Similar to NMA1721, fasta scores; E(): 2e-17, 31.0% identity in 226 aa overlap. Contains Pfam match to entry PF00494 SQS_PSY,Squalene and phytoene synthases; poly-isoprenyl transferase 1242881 907749 NMA1339 Neisseria meningitidis Z2491 poly-isoprenyl transferase YP_002342697.1 1242009 R 122587 CDS YP_002342698.1 218768186 907750 1243052..1244914 1 NC_003116.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 1244914 hscA 907750 hscA Neisseria meningitidis Z2491 chaperone protein HscA YP_002342698.1 1243052 D 122587 CDS YP_002342699.1 218768187 907751 1245237..1245800 1 NC_003116.1 NMA1341, len: 187 aa; unknown; hypothetical protein 1245800 907751 NMA1341 Neisseria meningitidis Z2491 hypothetical protein YP_002342699.1 1245237 D 122587 CDS YP_002342700.1 218768188 907752 1246037..1246597 1 NC_003116.1 NMA1343, len: 186 aa; unknown; hypothetical protein 1246597 907752 NMA1343 Neisseria meningitidis Z2491 hypothetical protein YP_002342700.1 1246037 D 122587 CDS YP_002342701.1 218768189 907753 1246652..1246993 1 NC_003116.1 NMA1344, fdx, probable ferredoxin, len: 113 aa; similar to many e.g. SW:FER_ECOLI (EMBL:M88654), fdx,Escherichia coli ferredoxin 2FE-2S (110 aa), fasta scores; E(): 1.2e-30, 67.3% identity in 110 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains; ferredoxin 1246993 907753 NMA1344 Neisseria meningitidis Z2491 ferredoxin YP_002342701.1 1246652 D 122587 CDS YP_002342702.1 218768190 907754 complement(1247280..1247867) 1 NC_003116.1 NMA1345, len: 195 aa; unknown; hypothetical protein 1247867 907754 NMA1345 Neisseria meningitidis Z2491 hypothetical protein YP_002342702.1 1247280 R 122587 CDS YP_002342703.1 218768191 907755 1248080..1248277 1 NC_003116.1 NMA1347, len: 65 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:O69223 (EMBL:AF010139) Azotobacter vinelandii hypothetical protein (68 aa), fasta scores; E(): 2.9e-14, 56.9% identity in 65 aa overlap; hypothetical protein 1248277 907755 NMA1347 Neisseria meningitidis Z2491 hypothetical protein YP_002342703.1 1248080 D 122587 CDS YP_002342704.1 218768192 907756 complement(1248345..1248746) 1 NC_003116.1 NMA1348, len: 133 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YRFH_ECOLI (EMBL:U18997),yrfH, Escherichia coli hypothetical protein (133 aa),fasta scores; E(): 1.3e-19, 45.5% identity in 132 aa overlap. Contains Pfam match to entry PF01479 S4, S4 domain; hypothetical protein 1248746 907756 NMA1348 Neisseria meningitidis Z2491 hypothetical protein YP_002342704.1 1248345 R 122587 CDS YP_002342705.1 218768193 907757 1248958..1249917 1 NC_003116.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 1249917 accA 907757 accA Neisseria meningitidis Z2491 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_002342705.1 1248958 D 122587 CDS YP_002342706.1 218768194 907758 1250015..1251295 1 NC_003116.1 NMA1350, len: 426 aa; unknown, similar to many bacterial hypothetical proteins e.g. SW:MESJ_ECOLI (EMBL:D49445), mesJ, Escherichia coli cell cycle protein (432 aa), fasta scores; E(): 0, 34.3% identity in 428 aa overlap; hypothetical protein 1251295 907758 NMA1350 Neisseria meningitidis Z2491 hypothetical protein YP_002342706.1 1250015 D 122587 CDS YP_002342707.1 218768195 907759 1251369..1252154 1 NC_003116.1 NMA1351, RNA methyltransferase, len: 261 aa; shows weak similarity to SW:TSNR_STRLU (EMBL:L39157),tsnR, Streptomyces laurentii rRNA (adenosine-2'-O-)-methyltransferase (270 aa), fasta scores; E(): 1.4e-07, 26.1% identity in 253 aa overlap. Similar to many hypothetical proteins e.g. SW:YG73_SYNY3 (EMBL:D90913), SLR1673, Synechocystis sp. (strain PCC 6803) hypothetical tRNA/rRNA methyltransferase (274 aa),fasta scores; E(): 9e-20, 34.1% identity in 267 aa overlap. Shows weak similarity to NMA1127, fasta scores; E(): 1.3e-10, 27.7% identity in 224 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family; RNA methyltransferase 1252154 907759 NMA1351 Neisseria meningitidis Z2491 RNA methyltransferase YP_002342707.1 1251369 D 122587 CDS YP_002342708.1 218768196 907760 1252205..1252441 1 NC_003116.1 NMA1353, lipoprotein, len: 78 aa; unknown,contains a N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, therefore may be a lipoprotein; lipoprotein 1252441 907760 NMA1353 Neisseria meningitidis Z2491 lipoprotein YP_002342708.1 1252205 D 122587 CDS YP_002342709.1 218768197 907761 1252563..1252976 1 NC_003116.1 NMA1354, len: 137 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1252976 907761 NMA1354 Neisseria meningitidis Z2491 hypothetical protein YP_002342709.1 1252563 D 122587 CDS YP_002342710.1 218768198 907762 1252988..1253293 1 NC_003116.1 NMA1355, periplasmic protein, len: 101 aa; unknown, contains a N-terminal signal sequence. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1253293 907762 NMA1355 Neisseria meningitidis Z2491 hypothetical protein YP_002342710.1 1252988 D 122587 CDS YP_002342711.1 218768199 907763 1253355..1254731 1 NC_003116.1 NMA1356, mpl, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso- diaminopimelate ligase, len: 458 aa; similar to SW:MPL_ECOLI (EMBL:U14003), mpl, Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso- diaminopimelate ligase (EC 6.3.2.-) (457 aa), fasta scores; E(): 0, 57.3% identity in 457 aa overlap. Shows weak similarity to NMA2061, fasta scores; E(): 1.5e-19, 28.4% identity in 479 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 1254731 907763 NMA1356 Neisseria meningitidis Z2491 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_002342711.1 1253355 D 122587 CDS YP_002342712.1 218768200 907765 1254938..1255990 1 NC_003116.1 NMA1358, bioB, probable biotin synthase, len: 350 aa; similar to many e.g. SW:BIOB_ECOLI (EMBL:J04423),bioB, Escherichia coli biotin synthase (EC 2.8.1.6) (346 aa), fasta scores; E(): 0, 59.1% identity in 308 aa overlap; biotin synthase 1255990 907765 NMA1358 Neisseria meningitidis Z2491 biotin synthase YP_002342712.1 1254938 D 122587 CDS YP_002342713.1 218768201 907766 complement(1256068..1256703) 1 NC_003116.1 NMA1359, len: 211 aa; unknown; hypothetical protein 1256703 907766 NMA1359 Neisseria meningitidis Z2491 hypothetical protein YP_002342713.1 1256068 R 122587 CDS YP_002342714.1 218768202 907767 complement(1256827..1257066) 1 NC_003116.1 NMA1360, len: 79 aa; unknown; hypothetical protein 1257066 907767 NMA1360 Neisseria meningitidis Z2491 hypothetical protein YP_002342714.1 1256827 R 122587 CDS YP_002342715.1 218768203 907768 complement(1257349..1259208) 1 NC_003116.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1259208 ilvD 907768 ilvD Neisseria meningitidis Z2491 dihydroxy-acid dehydratase YP_002342715.1 1257349 R 122587 CDS YP_002342716.1 218768204 907769 complement(1259381..1261150) 1 NC_003116.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 1261150 cysI 907769 cysI Neisseria meningitidis Z2491 sulfite reductase subunit beta YP_002342716.1 1259381 R 122587 CDS YP_002342717.1 218768205 907770 complement(1261177..1262991) 1 NC_003116.1 NMA1363, cysJ, probable sulphite reductase alpha subunit, len: 604 aa; similar to many e.g. SW:CYSJ_ECOLI (EMBL:M23008), cysJ, Escherichia coli sulfite reductase [NADPH] flavoprotein alpha-component (EC 1.8.1.2) (598 aa), fasta scores; E(): 0, 55.7% identity in 600 aa overlap. Contains Pfam matches to entry PF00667 FAD_binding, FAD binding domain and to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain; sulfite reductase subunit alpha 1262991 907770 NMA1363 Neisseria meningitidis Z2491 sulfite reductase subunit alpha YP_002342717.1 1261177 R 122587 CDS YP_002342718.1 218768206 907771 complement(1262988..1264274) 1 NC_003116.1 NMA1364, cysN, probable sulphate adenylate transferase subunit 1, len: 428 aa; similar to many e.g. SW:CYSN_ECOLI (EMBL:M74586), cysN, Escherichia coli sulfate adenylate transferase subunit 1 (EC 2.7.7.4) (475 aa), fasta scores; E(): 0, 46.8% identity in 432 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU,Elongation factor Tu family, PS00301 GTP-binding elongation factors signature and PS00017 ATP/GTP-binding site motif A (P-loop); sulfate adenylate transferase subunit 1 1264274 907771 NMA1364 Neisseria meningitidis Z2491 sulfate adenylate transferase subunit 1 YP_002342718.1 1262988 R 122587 CDS YP_002342719.1 218768207 907772 complement(1264313..1265236) 1 NC_003116.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 1265236 cysD 907772 cysD Neisseria meningitidis Z2491 sulfate adenylyltransferase subunit 2 YP_002342719.1 1264313 R 122587 CDS YP_002342720.1 218768208 907773 complement(1265274..1266008) 1 NC_003116.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 1266008 cysH 907773 cysH Neisseria meningitidis Z2491 phosphoadenosine phosphosulfate reductase YP_002342720.1 1265274 R 122587 CDS YP_002342721.1 218768209 907774 complement(1266024..1267484) 1 NC_003116.1 NMA1367, cysG, sirohaem synthase, len: 486 aa; highly similar to TR:P95370 (EMBL:Y10177), cysG, Neisseria meningitidis strain MC58 sirohaem synthase (EC 2.1.1.107) (475 aa), fasta scores; E(): 0, 97.5% identity in 474 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases,PS00839 Uroporphyrin-III C-methyltransferase signature 1 and PS00840 Uroporphyrin-III C-methyltransferase signature 2; siroheme synthase 1267484 907774 NMA1367 Neisseria meningitidis Z2491 siroheme synthase YP_002342721.1 1266024 R 122587 CDS YP_002342722.1 218768210 907775 complement(1267781..1268437) 1 NC_003116.1 NMA1368, membrane protein, len: 218 aa; similar to TR:Q46471 (EMBL:U25811) Chromatium vinosum hypothetical protein (231 aa), fasta scores; E(): 1.1e-23,37.9% identity in 211 aa overlap. Contains hydrophobic, membrane-spanning regions. C-terminus contains a poly-Ala tract; hypothetical protein 1268437 907775 NMA1368 Neisseria meningitidis Z2491 hypothetical protein YP_002342722.1 1267781 R 122587 CDS YP_002342723.1 218768211 907776 1268502..1269392 1 NC_003116.1 NMA1369, len: 296 aa; unknown, similar to the C-terminal half of bacterial hypothetical proteins e.g. SW:YJEF_ECOLI (EMBL:U14003), yjeF, Escherichia coli hypothetical protein (515 aa), fasta scores; E(): 7.8e-28,37.8% identity in 278 aa overlap. Contains Pfam match to entry PF01256 UPF0031, Uncharacterized protein family UPF0031; hypothetical protein 1269392 907776 NMA1369 Neisseria meningitidis Z2491 hypothetical protein YP_002342723.1 1268502 D 122587 CDS YP_002342724.1 218768212 907777 1269662..1271473 1 NC_003116.1 NMA1370, typA, probable GTP-binding protein, len: 603 aa; similar to many e.g. SW:TYPA_ECOLI (EMBL:L19201),typA, Escherichia coli GTP-binding protein implicated in regulation of virulence factors, fasta scores; E(): 0,64.1% identity in 599 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family,PS00301 GTP-binding elongation factors signature and PS00017 ATP/GTP-binding site motif A (P-loop); GTP-binding protein 1271473 907777 NMA1370 Neisseria meningitidis Z2491 GTP-binding protein YP_002342724.1 1269662 D 122587 CDS YP_002342725.1 218768213 907778 1272463..1274838 1 NC_003116.1 NMA1371, vacB, probable ribonuclease, len: 791 aa; similar to many e.g. SW:VACB_SHIFL (EMBL:D11024), vacB,Shigella flexneri chromosomal gene required for expression of virulence genes (also in enteroinvasive Escherichia coli) (760 aa), fasta scores; E(): 0, 44.9% identity in 762 aa overlap. May have a post-transcriptional regulatory role. Also similar to SW:RNB_ECOLI (EMBL:X67913), rnb,Escherichia coli exoribonuclease II (EC 3.1.13.1) (644 aa), fasta scores; E(): 0, 30.0% identity in 580 aa overlap. Contains Pfam matches to entry PF00773 RNB,RNB-like proteins and to entry PF00575 S1, S1 RNA binding domain and PS01175 Ribonuclease II family signature; ribonuclease 1274838 907778 NMA1371 Neisseria meningitidis Z2491 ribonuclease YP_002342725.1 1272463 D 122587 CDS YP_002342726.1 218768214 907779 complement(1275177..1276640) 1 NC_003116.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 1276640 guaB 907779 guaB Neisseria meningitidis Z2491 inosine 5'-monophosphate dehydrogenase YP_002342726.1 1275177 R 122587 CDS YP_002342727.1 218768215 907780 complement(1276967..1277428) 1 NC_003116.1 NMA1373, len: 153 aa; unknown; hypothetical protein 1277428 907780 NMA1373 Neisseria meningitidis Z2491 hypothetical protein YP_002342727.1 1276967 R 122587 CDS YP_002342728.1 218768216 907781 complement(1277519..1280077) 1 NC_003116.1 NMA1374, glnD, probable [protein-PII] uridylyltransferase, len: 852 aa; similar to many e.g. SW:GLND_ECOLI (EMBL:M96431), glnD, Escherichia coli [protein-PII] uridylyltransferase (EC 2.7.7.59) (890 aa),fasta scores; E(): 0, 33.1% identity in 865 aa overlap; [protein-PII] uridylyltransferase 1280077 907781 NMA1374 Neisseria meningitidis Z2491 [protein-PII] uridylyltransferase YP_002342728.1 1277519 R 122587 CDS YP_002342729.1 218768217 907782 complement(1280126..1280446) 1 NC_003116.1 NMA1375, transcriptional regulator, len: 106 aa; similar to e.g. regulatory proteins of restriction modification systems e.g. TR:Q52622 (EMBL:M77223), pvuIIC,Proteus vulgaris regulatory transcription factor C (84 aa), fasta scores; E(): 1.8e-05, 42.2% identity in 64 aa overlap. Similar to TR:AAD39136 (EMBL:AF123569), nmeSIC,Neisseria meningitidis strain 800615 (serotype B:4:P1.4) control element (70 aa), fasta scores; E(): 4.3e-05, 46.0% identity in 50 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. Contains a probable helix-turn-helix motif at aa 36-57 (Score 1818,+5.38 SD); transcriptional regulator 1280446 907782 NMA1375 Neisseria meningitidis Z2491 transcriptional regulator YP_002342729.1 1280126 R 122587 CDS YP_002342730.1 218768218 907783 complement(1280770..1281243) 1 NC_003116.1 NMA1376, bfrB, probable bacterioferritin B, len: 157 aa; similar to many e.g. SW:BFRB_NEIGO (EMBL:U76634),bfrB, Neisseria gonorrhoeae bacterioferritin B (157 aa),fasta scores; E(): 0, 99.4% identity in 157 aa overlap and SW:BFR_AZOVI (EMBL:M83692), bfr, Azotobacter vinelandii bacterioferritin (156 aa), fasta scores; E(): 0, 62.2% identity in 156 aa overlap. Similar to NMA1377, fasta scores; E(): 3.1e-17, 39.9% identity in 153 aa overlap; bacterioferritin B 1281243 907783 NMA1376 Neisseria meningitidis Z2491 bacterioferritin B YP_002342730.1 1280770 R 122587 CDS YP_002342731.1 218768219 907784 complement(1281271..1281735) 1 NC_003116.1 NMA1377, bfrA, probable bacterioferritin A, len: 154 aa; similar to many e.g. SW:BFRA_NEIGO (EMBL:U76633),bfrA, Neisseria gonorrhoeae bacterioferritin A (154 aa),fasta scores; E(): 0, 99.4% identity in 154 aa overlap and SW:BFR_PSEPU (EMBL:U66717), bfr, Pseudomonas putida bacterioferritin (154 aa), fasta scores; E(): 0, 61.0% identity in 154 aa overlap. Similar to NMA1376, fasta scores; E(): 2.2e-17, 39.9% identity in 153 aa overlap; bacterioferritin A 1281735 907784 NMA1377 Neisseria meningitidis Z2491 bacterioferritin A YP_002342731.1 1281271 R 122587 CDS YP_002342732.1 218768220 907785 complement(1282199..1283182) 1 NC_003116.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 1283182 lipA 907785 lipA Neisseria meningitidis Z2491 lipoyl synthase YP_002342732.1 1282199 R 122587 CDS YP_002342733.1 218768221 907786 complement(1283175..1283747) 1 NC_003116.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1283747 lipB 907786 lipB Neisseria meningitidis Z2491 lipoate-protein ligase B YP_002342733.1 1283175 R 122587 CDS YP_002342734.1 218768222 907787 complement(1283800..1284075) 1 NC_003116.1 NMA1380, len: 91 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YBED_ECOLI (EMBL:L07636),ybeD, Escherichia coli hypothetical protein (87 aa),fasta scores; E(): 3.1e-08, 37.8% identity in 82 aa overlap; hypothetical protein 1284075 907787 NMA1380 Neisseria meningitidis Z2491 hypothetical protein YP_002342734.1 1283800 R 122587 CDS YP_002342735.1 218768223 907788 1284260..1285330 1 NC_003116.1 NMA1381, probable integral membrane protein, len: 356 aa; similar to many bacterial hypothetical proteins e.g. SW:PERM_ECOLI (EMBL:AE000335), perm, Escherichia coli permease (353 aa), fasta scores; E(): 1.5e-19,26.2% identity in 313 aa overlap. Contains Pfam match to entry PF01594 DUF20, permease. Contains hydrophobic, probable membrane-spanning regions; integral membrane protein 1285330 907788 NMA1381 Neisseria meningitidis Z2491 integral membrane protein YP_002342735.1 1284260 D 122587 CDS YP_002342736.1 218768224 907789 complement(1285437..1286384) 1 NC_003116.1 NMA1382, periplasmic protein, len: 315 aa; similar to many hypothetical proteins found in both bacteria and eukaryotes e.g. TR:O60376 (EMBL:AC004472),P1.11659_4, Homo sapiens hypothetical protein (357 aa),fasta scores; E(): 0, 48.4% identity in 289 aa overlap and TR:Q9ZDK0 (EMBL:AJ235271), RP328, Rickettsia prowazekii hypothetical protein (311 aa), fasta scores; E(): 0, 48.6% identity in 315 aa overlap. Contains Pfam match to entry PF01145 Band_7, Band 7 family. Contains a probable N-terminal signal sequence; hypothetical protein 1286384 907789 NMA1382 Neisseria meningitidis Z2491 hypothetical protein YP_002342736.1 1285437 R 122587 CDS YP_002342737.1 218768225 907790 complement(1286399..1286806) 1 NC_003116.1 NMA1383, membrane protein, len: 135 aa; unknown, contains hydrophobic, membrane-spanning regions; hypothetical protein 1286806 907790 NMA1383 Neisseria meningitidis Z2491 hypothetical protein YP_002342737.1 1286399 R 122587 CDS YP_002342738.1 218768226 907791 1286887..1287546 1 NC_003116.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1287546 ung 907791 ung Neisseria meningitidis Z2491 uracil-DNA glycosylase YP_002342738.1 1286887 D 122587 CDS YP_002342739.1 218768227 7163868 complement(1290250..1290651) 1 NC_003116.1 hypothetical protein 1290651 7163868 NMA1386 Neisseria meningitidis Z2491 hypothetical protein YP_002342739.1 1290250 R 122587 CDS YP_002342740.1 218768228 907794 complement(1290696..1291211) 1 NC_003116.1 NMA1391, periplasmic protein, len: 171 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein 1291211 907794 NMA1391 Neisseria meningitidis Z2491 hypothetical protein YP_002342740.1 1290696 R 122587 CDS YP_002342741.1 218768229 907796 complement(1293624..1294019) 1 NC_003116.1 NMA1394, len: 131 aa; unknown; hypothetical protein 1294019 907796 NMA1394 Neisseria meningitidis Z2491 hypothetical protein YP_002342741.1 1293624 R 122587 CDS YP_002342742.1 218768230 907797 1294192..1295499 1 NC_003116.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1295499 hom 907797 hom Neisseria meningitidis Z2491 homoserine dehydrogenase YP_002342742.1 1294192 D 122587 CDS YP_002342743.1 218768231 907798 1295492..1295926 1 NC_003116.1 NMA1396, membrane protein, len: 144 aa; unknown, contains a hydrophobic, membrane-spanning region; hypothetical protein 1295926 907798 NMA1396 Neisseria meningitidis Z2491 hypothetical protein YP_002342743.1 1295492 D 122587 CDS YP_002342744.1 218768232 907799 complement(1295985..1296254) 1 NC_003116.1 NMA1397, hupB, probable DNA-binding protein, len: 89 aa; similar to many e.g. SW:DBHB_ECOLI (EMBL:X53241),hupB, Escherichia coli DNA-binding protein HU-beta (90 aa), fasta scores; E(): 1.4e-19, 68.5% identity in 89 aa overlap. Similar to NMA1868, fasta scores; E(): 3.6e-21,69.7% identity in 89 aa overlap. Contains Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein and PS00045 Bacterial histone-like DNA-binding proteins signature; DNA-binding protein 1296254 907799 NMA1397 Neisseria meningitidis Z2491 DNA-binding protein YP_002342744.1 1295985 R 122587 CDS YP_002342745.1 218768233 907800 complement(1296436..1298898) 1 NC_003116.1 NMA1398, lon, probable ATP-dependent protease, len: 820 aa; similar to many e.g. SW:LON_ECOLI (EMBL:L12349),lon, Escherichia coli ATP-dependent protease (EC 3.4.21.53) (784 aa), fasta scores; E(): 0, 65.5% identity in 796 aa overlap. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA), PS01046 ATP-dependent serine proteases, lon family,serine active site and PS00017 ATP/GTP-binding site motif A (P-loop); ATP-dependent protease 1298898 907800 NMA1398 Neisseria meningitidis Z2491 ATP-dependent protease YP_002342745.1 1296436 R 122587 CDS YP_002342746.1 218768234 907801 1299257..1300252 1 NC_003116.1 NMA1400, len: 331 aa; unknown, shows weak similarity to parts bacterial hypothetical proteins e.g. TR:CAB49354 (EMBL:AJ248284) Pyrococcus abyssi hypothetical protein (197 aa), fasta scores; E(): 1.5e-06, 33.5% identity in 179 aa overlap. Contains PS00092 N-6 Adenine-specific DNA methylases signature; hypothetical protein 1300252 907801 NMA1400 Neisseria meningitidis Z2491 hypothetical protein YP_002342746.1 1299257 D 122587 CDS YP_002342747.1 218768235 907802 complement(1300324..1302069) 1 NC_003116.1 NMA1401, recD, exodeoxyribonuclease V alpha subunit, len: 581 aa; highly similar to TR:O68924 (EMBL:AF058330), recD, Neisseria gonorrhoeae exodeoxyribonuclease V alpha subunit (581 aa), fasta scores; E(): 0, 95.2% identity in 580 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); exodeoxyribonuclease V subunit alpha 1302069 907802 NMA1401 Neisseria meningitidis Z2491 exodeoxyribonuclease V subunit alpha YP_002342747.1 1300324 R 122587 CDS YP_002342748.1 218768236 907803 complement(1302137..1302832) 1 NC_003116.1 NMA1402, probable ABC-transporter ATP-binding protein, len: 231 aa; similar to many e.g. SW:GLNQ_BACST (EMBL:M61017), glnQ, Bacillus stearothermophilus glutamine transport ATP-binding protein (242 aa), blastp scores; Expect 3.6e-29 and SW:YCFV_ECOLI (EMBL:AE000212), ycfV,Escherichia coli hypothetical ABC transporter ATP-binding protein (233 aa), fasta scores; E(): 0, 53.8% identity in 223 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); ABC transporter ATP-binding protein 1302832 907803 NMA1402 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002342748.1 1302137 R 122587 CDS YP_002342749.1 218768237 907804 complement(1302825..1304072) 1 NC_003116.1 NMA1403, integral membrane protein, len: 415 aa; unknown, similar to many bacterial hypothetical proteins e.g. SW:YCFW_ECOLI (EMBL:AE000212), yxfW,Escherichia coli hypothetical protein (414 aa), fasta scores; E(): 0, 35.3% identity in 405 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein 1304072 907804 NMA1403 Neisseria meningitidis Z2491 integral membrane protein YP_002342749.1 1302825 R 122587 CDS YP_002342750.1 218768238 907806 1304278..1304556 1 NC_003116.1 NMA1405, periplasmic protein, len: 92 aa; unknown, contains a N-terminal signal sequence; hypothetical protein 1304556 907806 NMA1405 Neisseria meningitidis Z2491 hypothetical protein YP_002342750.1 1304278 D 122587 CDS YP_002342751.1 218768239 907807 complement(1304612..1305229) 1 NC_003116.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1305229 recR 907807 recR Neisseria meningitidis Z2491 recombination protein RecR YP_002342751.1 1304612 R 122587 CDS YP_002342752.1 218768240 907808 complement(1305296..1306834) 1 NC_003116.1 NMA1407, peptidyl-prolyl cis-trans isomerase, len: 512 aa; similar to e.g. SW:CYPD_ECOLI (EMBL:AE000150), ppiD, Escherichia coli peptidyl-prolyl cis-trans isomerase D (EC 5.2.1.8) (623 aa), fasta scores; E(): 8.4e-14, 21.7% identity in 608 aa overlap. Contains a probable N-terminal signal sequence; peptidyl-prolyl cis-trans isomerase 1306834 907808 NMA1407 Neisseria meningitidis Z2491 peptidyl-prolyl cis-trans isomerase YP_002342752.1 1305296 R 122587 CDS YP_002342753.1 218768241 907809 complement(1306888..1307262) 1 NC_003116.1 NMA1408, len: 124 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YFFB_ECOLI (EMBL:X57403),yffB, Escherichia coli hypothetical protein (118 aa),fasta scores; E(): 5.8e-15, 38.5% identity in 117 aa overlap; hypothetical protein 1307262 907809 NMA1408 Neisseria meningitidis Z2491 hypothetical protein YP_002342753.1 1306888 R 122587 CDS YP_002342754.1 218768242 907810 1307412..1309040 1 NC_003116.1 NMA1409, probable ABC-transporter ATP-binding protein, len: 542 aa; similar to many e.g. SW:TLRC_STRFR (EMBL:M57437), tlrC, Streptomyces fradiae tylosin resistance ATP-binding protein (548 aa), blastp scores; Expect 1.4e-45 and SW:YBIT_ECOLI (EMBL:AE000184), ybiT,Escherichia coli hypothetical ABC-transporter ATP-binding protein (530 aa), fasta scores; E(): 0, 65.6% identity in 543 aa overlap. Contains two Pfam matches to entry PF00005 ABC_tran, ABC transporter and two PS00017 ATP/GTP-binding site motif A (P-loop); ABC transporter ATP-binding protein 1309040 907810 NMA1409 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002342754.1 1307412 D 122587 CDS YP_002342755.1 218768243 907811 1309112..1310365 1 NC_003116.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 1310365 cca 907811 cca Neisseria meningitidis Z2491 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_002342755.1 1309112 D 122587 CDS YP_002342756.1 218768244 907812 1310588..1310896 1 NC_003116.1 NMA1411, len: 102 aa; unknown; hypothetical protein 1310896 907812 NMA1411 Neisseria meningitidis Z2491 hypothetical protein YP_002342756.1 1310588 D 122587 CDS YP_002342757.1 218768245 907813 1310978..1312009 1 NC_003116.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1312009 ruvB 907813 ruvB Neisseria meningitidis Z2491 Holliday junction DNA helicase RuvB YP_002342757.1 1310978 D 122587 CDS YP_002342758.1 218768246 907814 complement(1312032..1312760) 1 NC_003116.1 NMA1413, rpe, probable ribulose-phosphate 3-epimerase, len: 242 aa; similar to many e.g. SW:RPE_ECOLI (EMBL:Z19601), rpe, Escherichia coli ribulose-phosphate 3-epimerase (EC 5.1.3.1) (225 aa),fasta scores; E(): 0, 66.2% identity in 225 aa overlap. Contains Pfam match to entry PF00834 Ribul_P_3_epim,Ribulose-phosphate 3 epimerase family, PS01085 Ribulose-phosphate 3-epimerase family signature 1 and PS01086 Ribulose-phosphate 3-epimerase family signature 2; ribulose-phosphate 3-epimerase 1312760 907814 NMA1413 Neisseria meningitidis Z2491 ribulose-phosphate 3-epimerase YP_002342758.1 1312032 R 122587 CDS YP_002342759.1 218768247 907815 1313071..1313505 1 NC_003116.1 NMA1414, periplasmic protein, len: 144 aa; shows weak similarity to SW:SPY_ECOLI (EMBL:Y07714), spy,Escherichia coli spheroplast protein (161 aa), fasta scores; E(): 0.0013, 27.6% identity in 134 aa overlap. Contains a N-terminal signal sequence; hypothetical protein 1313505 907815 NMA1414 Neisseria meningitidis Z2491 hypothetical protein YP_002342759.1 1313071 D 122587 CDS YP_002342760.1 218768248 907816 complement(1313518..1314381) 1 NC_003116.1 NMA1415, len: 287 aa; unknown, similar to the C-terminal half of TR:Q55502 (EMBL:D64006) Synechocystis sp. (strain PCC 6803) hypothetical protein (436 aa), fasta scores; E(): 0, 46.9% identity in 241 aa overlap and also to TR:O66668 (EMBL:AE000684), AQ_336, Aquifex aeolicus hypothetical protein (196 aa), fasta scores; E(): 3.4e-19,46.5% identity in 142 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1314381 907816 NMA1415 Neisseria meningitidis Z2491 hypothetical protein YP_002342760.1 1313518 R 122587 CDS YP_002342761.1 218768249 907817 complement(1314389..1315006) 1 NC_003116.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1315006 ribC 907817 ribC Neisseria meningitidis Z2491 riboflavin synthase subunit alpha YP_002342761.1 1314389 R 122587 CDS YP_002342762.1 218768250 907818 complement(1315169..1315747) 1 NC_003116.1 NMA1417, molybdopterin-guanine dinucleotide biosynthesis protein A, len: 192 aa; similar to bacterial mobA genes e.g. SW:MOBA_ECOLI (EMBL:L19201),mobA, Escherichia coli molybdopterin-guanine dinucleotide biosynthesis protein A (194 aa), fasta scores; E(): 1.9e-14, 31.4% identity in 185 aa overlap; molybdopterin-guanine dinucleotide biosynthesis protein A 1315747 907818 NMA1417 Neisseria meningitidis Z2491 molybdopterin-guanine dinucleotide biosynthesis protein A YP_002342762.1 1315169 R 122587 CDS YP_002342763.1 218768251 907819 1315989..1317761 1 NC_003116.1 NMA1418, probable two-component system sensor kinase, len: 590 aa; similar to many e.g. SW:NARX_ECOLI (EMBL:X13360), narX, Escherichia coli nitrate/nitrite sensor protein (EC 2.7.3.-) (598 aa), fasta scores; E(): 3.2e-17, 25.9% identity in 609 aa overlap. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains two hydrophobic, membrane-spanning regions; two-component system sensor kinase 1317761 907819 NMA1418 Neisseria meningitidis Z2491 two-component system sensor kinase YP_002342763.1 1315989 D 122587 CDS YP_002342764.1 218768252 907820 1317758..1318414 1 NC_003116.1 NMA1419, probable two-component system response regulator, len: 218 aa; similar to many e.g. TR:CAB44989 (EMBL:AJ131854), narL, Pseudomonas stutzeri nitrate and nitrite response regulator (218 aa), fasta scores; E(): 8.5e-31, 43.3% identity in 210 aa overlap. Contains probable helix-turn-helix motif at aa 169-190 (Score 1324,+3.70 SD). Contains Pfam matches to entry PF00072 response_reg, Response regulator receiver domain and to entry PF00196 GerE, Bacterial regulatory proteins, luxR family and PS00622 Bacterial regulatory proteins, luxR family signature; two-component system response regulator 1318414 907820 NMA1419 Neisseria meningitidis Z2491 two-component system response regulator YP_002342764.1 1317758 D 122587 CDS YP_002342765.1 218768253 907822 complement(1318885..1319919) 1 NC_003116.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 1319919 purM 907822 purM Neisseria meningitidis Z2491 phosphoribosylaminoimidazole synthetase YP_002342765.1 1318885 R 122587 CDS YP_002342766.1 218768254 907824 1320677..1321351 1 NC_003116.1 NMA1424, len: 224 aa; unknown; hypothetical protein 1321351 907824 NMA1424 Neisseria meningitidis Z2491 hypothetical protein YP_002342766.1 1320677 D 122587 CDS YP_002342767.1 218768255 907825 1321344..1321937 1 NC_003116.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1321937 ribA 907825 ribA Neisseria meningitidis Z2491 GTP cyclohydrolase II YP_002342767.1 1321344 D 122587 CDS YP_002342768.1 218768256 907828 1323578..1324669 1 NC_003116.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II-like protein; functions in riboflavin synthesis; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein 1324669 ribB 907828 ribB Neisseria meningitidis Z2491 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein YP_002342768.1 1323578 D 122587 CDS YP_002342769.1 218768257 907831 complement(1326807..1328117) 1 NC_003116.1 NMA1433, len: 436 aa; unknown, similar to many hypothetical proteins e.g. SW:YCAJ_HAEIN (EMBL:U32833),HI1590, Haemophilus influenzae hypothetical protein (446 aa), fasta scores; E(): 0, 54.0% identity in 437 aa overlap. may have some role in DNA replication or repair as the N-terminal half is similar to yeast replication factors e.g. SW:RFC3_YEAST (EMBL:L18755), rfc3,Saccharomyces cerevisiae replication factor C 40 kD subunit (340 aa), fasta scores; E(): 1.4e-10, 30.5% identity in 233 aa overlap and to bacterial helicase components SW:RUVB_THEMA (EMBL:U38840), ruvB, Thermotoga maritima (334 aa), fasta scores; E(): 1.1e-07, 28.3% identity in 244 aa overlap. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA) and PS00017 ATP/GTP-binding site motif A (P-loop); recombination factor protein RarA 1328117 907831 NMA1433 Neisseria meningitidis Z2491 recombination factor protein RarA YP_002342769.1 1326807 R 122587 CDS YP_002342770.1 218768258 907832 1328366..1328851 1 NC_003116.1 NMA1435, len: 161 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1328851 907832 NMA1435 Neisseria meningitidis Z2491 hypothetical protein YP_002342770.1 1328366 D 122587 CDS YP_002342771.1 218768259 907833 1328851..1329630 1 NC_003116.1 NMA1436, len: 259 aa; unknown, rich in Ser, Thr and Asn, lies within a region of unusually low GC content; hypothetical protein 1329630 907833 NMA1436 Neisseria meningitidis Z2491 hypothetical protein YP_002342771.1 1328851 D 122587 CDS YP_002342772.1 218768260 907834 complement(1329902..1330816) 1 NC_003116.1 NMA1437, probable lysR-family transcriptional regulator, len: 304 aa; shows weak similarity to many e.g. SW:XAPR_ECOLI (EMBL:X63976), xapR, Escherichia coli xanthosine operon regulatory protein (294 aa), fasta scores; E(): 1.6e-11, 23.7% identity in 295 aa overlap and TR:O30441 (EMBL:AF006000), brg1, Bordetella pertussis transcriptional regulator homologue regulated by the oxygen-responsive transcriptional regulator btr (291 aa),fasta scores; E(): 5.4e-13, 28.7% identity in 296 aa overlap. Contains probable helix-turn-helix motif at aa 17-38 (Score 1810, +5.35 SD). Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and PS00044 Bacterial regulatory proteins, lysR family signature; lysR-family transcriptional regulator 1330816 907834 NMA1437 Neisseria meningitidis Z2491 lysR-family transcriptional regulator YP_002342772.1 1329902 R 122587 CDS YP_002342773.1 218768261 907835 1331072..1332541 1 NC_003116.1 NMA1438, integral membrane protein, len: 489 aa; unknown, contains hydrophobic, membrane-spanning regions; integral membrane protein 1332541 907835 NMA1438 Neisseria meningitidis Z2491 integral membrane protein YP_002342773.1 1331072 D 122587 CDS YP_002342774.1 218768262 907836 1332793..1333164 1 NC_003116.1 NMA1439, lipoprotein, len: 123 aa; unknown, contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 1333164 907836 NMA1439 Neisseria meningitidis Z2491 lipoprotein YP_002342774.1 1332793 D 122587 CDS YP_002342775.1 218768263 907837 1333237..1334646 1 NC_003116.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1334646 thrC 907837 thrC Neisseria meningitidis Z2491 threonine synthase YP_002342775.1 1333237 D 122587 CDS YP_002342776.1 218768264 907838 1334693..1335487 1 NC_003116.1 NMA1441, len: 264 aa; unknown; hypothetical protein 1335487 907838 NMA1441 Neisseria meningitidis Z2491 hypothetical protein YP_002342776.1 1334693 D 122587 CDS YP_002342777.1 218768265 907839 1335675..1336451 1 NC_003116.1 NMA1442, fpr, probable ferredoxin--NADP reductase,len: 258 aa; similar to many e.g. SW:FENR_AZOVI (EMBL:L36319), fpr, Azotobacter vinelandii ferredoxin--NADP reductase (EC 1.18.1.2) (257 aa), fasta scores; E(): 0, 69.8% identity in 255 aa overlap. Similar to NMA1664, fasta scores; E(): 1.3e-30, 34.6% identity in 257 aa overlap. Contains Pfam match to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain; ferredoxin--NADP reductase 1336451 907839 NMA1442 Neisseria meningitidis Z2491 ferredoxin--NADP reductase YP_002342777.1 1335675 D 122587 CDS YP_002342778.1 218768266 907841 complement(1337108..1339579) 1 NC_003116.1 NMA1444, probable P-type cation-transporting ATPase, len: 823 aa; similar to many e.g. SW:COPA_ENTHR (EMBL:L13292), copA, Enterococcus hirae copper/potassium-transporting ATPase A (EC 3.6.1.36) (727 aa), fasta scores; E(): 0, 34.0% identity in 744 aa overlap. Similar to NMA1539, fasta scores; E(): 0, 34.4% identity in 735 aa overlap. Contains hydrophobic, probable membrane-spanning regions. Contains two Pfam matches to entry PF00122 E1-E2_ATPase, E1-E2 ATPases and PS00154 E1-E2 ATPases phosphorylation site; P-type cation-transporting ATPase 1339579 907841 NMA1444 Neisseria meningitidis Z2491 P-type cation-transporting ATPase YP_002342778.1 1337108 R 122587 CDS YP_002342779.1 218768267 907842 complement(1339576..1340685) 1 NC_003116.1 NMA1445, len: 369 aa; unknown, similar to many hypothetical proteins contains ATP/GTP-binding domains e.g. SW:HFLX_ECOLI (EMBL:U00005), hflX,Escherichia coli GTP-binding protein (426 aa), fasta scores; E(): 0, 48.5% identity in 375 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1340685 907842 NMA1445 Neisseria meningitidis Z2491 hypothetical protein YP_002342779.1 1339576 R 122587 CDS YP_002342780.1 218768268 907843 complement(1340759..1342039) 1 NC_003116.1 NMA1446, periplasmic protein, len: 426 aa; contains N-terminal signal sequence; hypothetical protein 1342039 907843 NMA1446 Neisseria meningitidis Z2491 hypothetical protein YP_002342780.1 1340759 R 122587 CDS YP_002342781.1 218768269 907844 complement(1342192..1342917) 1 NC_003116.1 NMA1447, len: 241 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:Y882_HAEIN (EMBL:U32770),HI0882, Haemophilus influenzae hypothetical protein (245 aa), fasta scores; E(): 0, 76.9% identity in 212 aa overlap; hypothetical protein 1342917 907844 NMA1447 Neisseria meningitidis Z2491 hypothetical protein YP_002342781.1 1342192 R 122587 CDS YP_002342782.1 218768270 907845 complement(1342990..1343667) 1 NC_003116.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1343667 radC 907845 radC Neisseria meningitidis Z2491 DNA repair protein RadC YP_002342782.1 1342990 R 122587 CDS YP_002342783.1 218768271 907846 complement(1343790..1345139) 1 NC_003116.1 NMA1449, gshA, probable glutamate--cysteine ligase,len: 449 aa; similar to TR:Q56277 (EMBL:U81808), gshA,Thiobacillus ferrooxidans glutamate--cysteine ligase (EC 6.3.2.2) (436 aa), fasta scores; E(): 0, 45.7% identity in 446 aa overlap; glutamate--cysteine ligase 1345139 907846 NMA1449 Neisseria meningitidis Z2491 glutamate--cysteine ligase YP_002342783.1 1343790 R 122587 CDS YP_002342784.1 218768272 907847 1345395..1346804 1 NC_003116.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1346804 leuC 907847 leuC Neisseria meningitidis Z2491 isopropylmalate isomerase large subunit YP_002342784.1 1345395 D 122587 CDS YP_002342785.1 218768273 907848 1346901..1347155 1 NC_003116.1 NMA1451, lipoprotein, len: 84 aa; unknown,contains N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 1347155 907848 NMA1451 Neisseria meningitidis Z2491 lipoprotein YP_002342785.1 1346901 D 122587 CDS YP_002342786.1 218768274 907849 1347217..1347858 1 NC_003116.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1347858 leuD 907849 leuD Neisseria meningitidis Z2491 isopropylmalate isomerase small subunit YP_002342786.1 1347217 D 122587 CDS YP_002342787.1 218768275 907850 1348033..1349304 1 NC_003116.1 NMA1453, DNA modification methylase, len: 423 aa; almost identical to SW:MTN4_NEILA (EMBL:U06074) Neisseria lactamica modification methylase NlaIV (EC ) (423 aa), fasta scores; E(): 0, 99.1% identity in 423 aa overlap and TR:Q59605 (EMBL:U43735), dcmE, Neisseria gonorrhoeae modification methylase (EC ) (423 aa),fasta scores; E(): 0, 97.9% identity in 423 aa overlap. Also similar to others from Neisseria meningitidis e.g. NMA1035, fasta scores; E(): 4.5e-21, 29.2% identity in 432 aa overlap. Contains Pfam match to entry PF00145 DNA_methylase, C-5 cytosine-specific DNA methylase and PS00094 C-5 cytosine-specific DNA methylases active site. Lies within a region of unusually low GC content; DNA modification methylase 1349304 907850 NMA1453 Neisseria meningitidis Z2491 DNA modification methylase YP_002342787.1 1348033 D 122587 CDS YP_002342788.1 218768276 907852 1350085..1351155 1 NC_003116.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1351155 leuB 907852 leuB Neisseria meningitidis Z2491 3-isopropylmalate dehydrogenase YP_002342788.1 1350085 D 122587 CDS YP_002342789.1 218768277 907853 1351318..1351881 1 NC_003116.1 NMA1457, periplasmic protein, len: 187 aa; unknown, contains a N-terminal signal sequence; hypothetical protein 1351881 907853 NMA1457 Neisseria meningitidis Z2491 hypothetical protein YP_002342789.1 1351318 D 122587 CDS YP_002342790.1 218768278 907854 1352342..1353739 1 NC_003116.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 1353739 aspA 907854 aspA Neisseria meningitidis Z2491 aspartate ammonia-lyase YP_002342790.1 1352342 D 122587 CDS YP_002342791.1 218768279 907855 complement(1353811..1354686) 1 NC_003116.1 NMA1460, probable integral membrane protein, len: 291 aa; similar to SW:YD76_HAEIN (EMBL:U32818), HI1376,Haemophilus influenzae hypothetical protein (291 aa),fasta scores; E(): 0, 54.8% identity in 292 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein 1354686 907855 NMA1460 Neisseria meningitidis Z2491 integral membrane protein YP_002342791.1 1353811 R 122587 CDS YP_002342792.1 218768280 907856 complement(1354688..1355410) 1 NC_003116.1 NMA1461, probable dnaJ-family protein, len: 240 aa; unknown, N-terminal approx. 70 aa contains a J-domain,suggesting involvement with hsp70, while the remainder of the protein contains two hydrophobic, membrane-spanning regions. Only the N-terminus shows significant similarity to other proteins e.g. SW:DNAJ_LEGPN (EMBL:U15010), dnaJ, Legionella pneumophila DnaJ protein (379 aa), fasta scores; E(): 1.6e-09,65.6% identity in 64 aa overlap. Contains Pfam match to entry PF00226 DnaJ, DnaJ domain and PS00636 Nt-dnaJ domain signature; dnaJ-family protein 1355410 907856 NMA1461 Neisseria meningitidis Z2491 dnaJ-family protein YP_002342792.1 1354688 R 122587 CDS YP_002342793.1 218768281 907857 complement(1355589..1356068) 1 NC_003116.1 NMA1462, len: 159 aa; unknown, shows weak similarity to SW:EBSC_ENTFA (EMBL:L23802) Enterococcus faecalis regulatory protein (164 aa), fasta scores; E(): 3.6e-08, 23.8% identity in 143 aa overlap and to other bacterial hypothetical proteins e.g. SW:YBAK_ECOLI (EMBL:AE000154), ybaK, Escherichia coli hypothetical protein (159 aa), fasta scores; E(): 1.2e-12,35.7% identity in 157 aa overlap; hypothetical protein 1356068 907857 NMA1462 Neisseria meningitidis Z2491 hypothetical protein YP_002342793.1 1355589 R 122587 CDS YP_002342794.1 218768282 907858 1356143..1356505 1 NC_003116.1 NMA1463, len: 120 aa; unknown, similar to hypothetical proteins e.g. SW:Y117_HAEDU (EMBL:AF017750) Haemophilus ducreyi hypothetical protein (117 aa), fasta scores; E(): 1e-17, 46.8% identity in 111 aa overlap. Contains Pfam match to entry PF01042 DUF10, Domain of unknown function; hypothetical protein 1356505 907858 NMA1463 Neisseria meningitidis Z2491 hypothetical protein YP_002342794.1 1356143 D 122587 CDS YP_002342795.1 218768283 907859 1356537..1357403 1 NC_003116.1 NMA1464, len: 288 aa; unknown, shows very weak similarity to some bacterial hypothetical proteins e.g. SW:UP14_ECOLI (EMBL:U28375), ygfZ, Escherichia coli hypothetical protein (325 aa), fasta scores; E(): 1.2e-07,25.0% identity in 284 aa overlap; hypothetical protein 1357403 907859 NMA1464 Neisseria meningitidis Z2491 hypothetical protein YP_002342795.1 1356537 D 122587 CDS YP_002342796.1 218768284 907860 1357496..1358455 1 NC_003116.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1358455 907860 NMA1465 Neisseria meningitidis Z2491 C32 tRNA thiolase YP_002342796.1 1357496 D 122587 CDS YP_002342797.1 218768285 907861 complement(1358548..1361487) 1 NC_003116.1 NMA1466, probable type III restriction-modification system endonuclease, len: 979 aa; similar to many e.g. SW:T3RE_BPP1 (EMBL:X06287), res, bacteriophage P1 type III restriction-modification system EcoPI enzyme (EC 3.1.21.5) (970 aa), fasta scores; E(): 0, 55.8% identity in 980 aa overlap; type III restriction-modification system endonuclease 1361487 907861 NMA1466 Neisseria meningitidis Z2491 type III restriction-modification system endonuclease YP_002342797.1 1358548 R 122587 CDS YP_002342798.1 218768286 907864 complement(1363554..1364111) 1 NC_003116.1 NMA1469, ppiA, probable peptidyl-prolyl cis-trans isomerase A, len: 185 aa; similar to many e.g. SW:CYPH_ECOLI (EMBL:M55429), ppiB, Escherichia coli probable peptidyl-prolyl cis-trans isomerase A precursor (EC 5.2.1.8) (190 aa), fasta scores; E(): 9.4e-32, 54.9% identity in 182 aa overlap. Also similar to NMA1002, fasta scores; E(): 7.9e-21, 45.7% identity in 162 aa overlap. Contains Pfam match to entry PF00160 pro_isomerase,Peptidyl-prolyl cis-trans isomerase and PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature; peptidyl-prolyl cis-trans isomerase A 1364111 907864 NMA1469 Neisseria meningitidis Z2491 peptidyl-prolyl cis-trans isomerase A YP_002342798.1 1363554 R 122587 CDS YP_002342799.1 218768287 907865 complement(1364176..1365102) 1 NC_003116.1 NMA1470, len: 308 aa; unknown, similar to SW:YEIR_ECOLI (EMBL:AE000307), yeiR, Escherichia coli hypothetical protein (328 aa), fasta scores; E(): 1.1e-27,33.3% identity in 318 aa overlap. Also shows similarity at the N-terminus to SW:COBW_PSEDE (EMBL M62866), cobW,Pseudomonas denitrificans gene involved in cobalamin biosynthesis (353 aa), fasta scores; E(): 6.4e-11, 28.8% identity in 215 aa overlap; hypothetical protein 1365102 907865 NMA1470 Neisseria meningitidis Z2491 hypothetical protein YP_002342799.1 1364176 R 122587 CDS YP_002342800.1 218768288 907866 complement(1365090..1365566) 1 NC_003116.1 NMA1471, cation uptake regulator, len: 158 aa; shows weak similarity to many cation uptake regulator proteins e.g. SW:ZUR_ECOLI (EMBL:U00006), zur, Escherichia coli zinc uptake regulation protein (171 aa), fasta scores; E(): 4.1e-07 30.6% identity in 160 aa overlap and SW:FUR_STAEP (EMBL:X97011), fur, Staphylococcus epidermidis ferric uptake regulation protein (138 aa),fasta scores; E(): 0.22, 22.8% identity in 158 aa overlap. Also similar to a protein identified as a virulence candidate in Pseudomonas aeruginosa TR:P72159 (EMBL:U58365), np20, fasta scores; E(): 1e-07, 37.3% identity in 75 aa overlap; cation uptake regulator 1365566 907866 NMA1471 Neisseria meningitidis Z2491 cation uptake regulator YP_002342800.1 1365090 R 122587 CDS YP_002342801.1 218768289 907867 complement(1365637..1366092) 1 NC_003116.1 NMA1472, probable low molecular weight protein-tyrosine-phosphatase, len: 151 aa; similar to many protein-tyrosine-phosphatases e.g. SW:PTPA_STRCO (EMBL:U37580), ptpA, Streptomyces coelicolor A3(2) low molecular weight protein-tyrosine-phosphatase (EC 3.1.3.48) (164 aa), fasta scores; E(): 3e-16, 39.2% identity in 153 aa overlap and SW:PPAL_SCHPO (EMBL:L33929), stp1, Schizosaccharomyces pombe low molecular weight phosphotyrosine protein phosphatase (EC 3.1.3.48) (156 aa), fasta scores; E(): 2.7e-13, 40.2% identity in 132 aa overlap. Contains Pfam match to entry PF01451 LMWPc, Low molecular weight phosphotyrosine protein phosphatase; protein-tyrosine-phosphatase 1366092 907867 NMA1472 Neisseria meningitidis Z2491 protein-tyrosine-phosphatase YP_002342801.1 1365637 R 122587 CDS YP_002342802.1 218768290 907868 complement(1366217..1367332) 1 NC_003116.1 NMA1473, len: 371 aa; unknown, similar to many bacterial hypothetical proteins e.g. SW:YXAA_BACSU (EMBL:AB005554), yxaA, Bacillus subtilis hypothetical protein (382 aa), fasta scores; E(): 0, 40.2% identity in 378 aa overlap. Lies within a region of unusually low GC content; hypothetical protein 1367332 907868 NMA1473 Neisseria meningitidis Z2491 hypothetical protein YP_002342802.1 1366217 R 122587 CDS YP_002342803.1 218768291 907869 complement(1367446..1368543) 1 NC_003116.1 NMA1474, len: 365 aa; unknown; hypothetical protein 1368543 907869 NMA1474 Neisseria meningitidis Z2491 hypothetical protein YP_002342803.1 1367446 R 122587 CDS YP_002342804.1 218768292 907870 complement(1368626..1370257) 1 NC_003116.1 NMA1475, len: 543 aa; unknown, shares N-terminal similarity with some bacterial hypothetical proteins e.g. TR:O05979 (EMBL:Y11779) Rickettsia prowazekii hypothetical protein (216 aa), fasta scores; E(): 3e-29, 43.8% identity in 185 aa overlap; hypothetical protein 1370257 907870 NMA1475 Neisseria meningitidis Z2491 hypothetical protein YP_002342804.1 1368626 R 122587 CDS YP_002342805.1 218768293 907871 complement(1370357..1370641) 1 NC_003116.1 NMA1476, mercuric ion binding protein,len: 94 aa; similar to many small mercuric ion binding proteins e.g. SW:MERP_ACICA (EMBL:L04303), merP,Acinetobacter calcoaceticus plasmid pKLH2 mercuric transport protein periplasmic component precursor (91 aa),fasta scores; E(): 3e-06, 37.7% identity in 69 aa overlap and SW:MERP_PSEFL (EMBL:X73112), merP, Pseudomonas fluorescens plasmid pMER327 mercuric transport protein periplasmic component precursor (91 aa), fasta scores; E(): 4.9e-06, 36.2% identity in 69 aa overlap. Contains Pfam match to entry PF00403 HMA, Heavy-metal-associated domain; mercuric ion binding protein 1370641 907871 NMA1476 Neisseria meningitidis Z2491 mercuric ion binding protein YP_002342805.1 1370357 R 122587 CDS YP_002342806.1 218768294 907872 1371201..1372637 1 NC_003116.1 NMA1478, polysaccharide modification protein, len: 478 aa; similar to TR:Q51392 (EMBL:U50202),algI, Pseudomonas aeruginosa protein involved in alginate O-acetylation (520 aa), fasta scores; E(): 4.9e-33, 32.9% identity in 444 aa overlap and TR:O70067 (EMBL:AF049357),glg2, Streptococcus mutans CDS involved in intracellular polysaccharide accumulation (420 aa), fasta scores; E(): 1.5e-21, 28.7% identity in 407 aa overlap. Also shows weaker similarity to SW:DLTB_BACSU (EMBL:X73124), dltB,Bacillus subtilis protein involved in biosynthesis of D-alanyl-lipoteichoic acid (395 aa), fasta scores; E(): 3.1e-17, 25.3% identity in 395 aa overlap. Contains hydrophobic, membrane-spanning regions; polysaccharide modification protein 1372637 907872 NMA1478 Neisseria meningitidis Z2491 polysaccharide modification protein YP_002342806.1 1371201 D 122587 CDS YP_002342807.1 218768295 907873 1372648..1373631 1 NC_003116.1 NMA1479, periplasmic protein, len: 327 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein 1373631 907873 NMA1479 Neisseria meningitidis Z2491 hypothetical protein YP_002342807.1 1372648 D 122587 CDS YP_002342808.1 218768296 907874 1373628..1374821 1 NC_003116.1 NMA1480, periplasmic protein, len: 397 aa; unknown, contains a N-terminal signal sequence; hypothetical protein 1374821 907874 NMA1480 Neisseria meningitidis Z2491 hypothetical protein YP_002342808.1 1373628 D 122587 CDS YP_002342809.1 218768297 907875 complement(1375082..1376047) 1 NC_003116.1 NMA1481, probable transposase for IS1655, len: 321 aa; similar to many e.g. SW:TRA4_BACFR (EMBL:M17808) Bacteroides fragilis transposase for insertion sequence element (326 aa), fasta scores; E(): 0, 42.3% identity in 310 aa overlap. Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family. Contains probable helix-turn-helix motif at aa 22-43 (Score 1705, +4.99 SD); transposase for IS1655 1376047 907875 NMA1481 Neisseria meningitidis Z2491 transposase for IS1655 YP_002342809.1 1375082 R 122587 CDS YP_002342810.1 218768298 907876 1376191..1377744 1 NC_003116.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1377744 907876 NMA1482 Neisseria meningitidis Z2491 long-chain-fatty-acid--CoA ligase YP_002342810.1 1376191 D 122587 CDS YP_002342811.1 218768299 907877 complement(1377835..1379817) 1 NC_003116.1 NMA1483, probable transmembrane transport protein,len: 660 aa; similar to many e.g. SW:OPUD_BACSU (EMBL:U50082), opuD, Bacillus subtilis glycine betaine transporter (512 aa), fasta scores; E(): 0, 42.8% identity in 493 aa overlap and SW:BETT_ECOLI (EMBL:X52905), betT,Escherichia coli high-affinity choline transport protein (677 aa), fasta scores; E(): 0, 34.2% identity in 663 aa overlap. Possibly involved in osmotic regulation. Highly similar to SW:YH06_HAEIN (EMBL:U32843), HI1706,Haemophilus influenzae probable transport protein (669 aa), fasta scores; E(): 0, 75.8% identity in 669 aa overlap. Contains hydrophobic, probable membrane-spanning regions. Contains PS01303 BCCT family of transporters signature; transmembrane transport protein 1379817 907877 NMA1483 Neisseria meningitidis Z2491 transmembrane transport protein YP_002342811.1 1377835 R 122587 CDS YP_002342812.1 218768300 907879 1380151..1382157 1 NC_003116.1 NMA1485, gcr, site-specific recombinase, len: 668 aa; highly similar to TR:O05319 (EMBL:U82253) Neisseria gonorrhoeae site-specific recombinase (439 aa), fasta scores; E(): 0, 96.6% identity in 439 aa overlap. GC frameplot and codon usage plots predict a start codon 678 bp upstream of the functionally characterised start codon described in EMBL:U82253. The sequence described in EMBL:U82253 does not extend upstream of codon 188 in our predicted CDS; site-specific recombinase 1382157 907879 NMA1485 Neisseria meningitidis Z2491 site-specific recombinase YP_002342812.1 1380151 D 122587 CDS YP_002342813.1 218768301 907880 1382368..1383333 1 NC_003116.1 NMA1486, probable transposase for IS1655, len: 321 aa; similar to many e.g. SW:TRA4_BACFR (EMBL:M17808) Bacteroides fragilis transposase for insertion sequence element (326 aa), fasta scores; E(): 0, 42.3% identity in 310 aa overlap. Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family. Contains probable helix-turn-helix motif at aa 22-43 (Score 1705, +4.99 SD); transposase for IS1655 1383333 907880 NMA1486 Neisseria meningitidis Z2491 transposase for IS1655 YP_002342813.1 1382368 D 122587 CDS YP_002342814.1 218768302 907881 1383398..1383991 1 NC_003116.1 NMA1487, transposase for IS1016, len: 197 aa; similar to many e.g. TR:Q48234 (EMBL:X59756) ORF from Haemophilus influenzae insertion sequence IS1016-V6 (191 aa), fasta scores; E(): 0, 70.3% identity in 175 aa overlap.; transposase for IS1016 1383991 907881 NMA1487 Neisseria meningitidis Z2491 transposase for IS1016 YP_002342814.1 1383398 D 122587 CDS YP_002342815.1 218768303 907882 complement(1384238..1385230) 1 NC_003116.1 NMA1488, mltB, murein hydrolase, len: 321aa; similar to several eg. SW:P41052 (MLTB_ECOLI) membrane-bound lytic murein transglycosylase from Escherichia coli (361 aa) fasta scores; E(): 0, 38.4% identity in 310 aa overlap. Contains N-terminal signal sequence.; murein hydrolase 1385230 907882 NMA1488 Neisseria meningitidis Z2491 murein hydrolase YP_002342815.1 1384238 R 122587 CDS YP_002342816.1 218768304 907884 complement(1385549..1387102) 1 NC_003116.1 NMA1490, oxidoreductase, len: 517aa; weakly similar to many acyl-dehydrogenases eg. SW:P52042 (ACDS_CLOAB) (379 aa) fasta scores; E(): 0.00073, 20.8% identity in 380 aa overlap.; oxidoreductase 1387102 907884 NMA1490 Neisseria meningitidis Z2491 oxidoreductase YP_002342816.1 1385549 R 122587 CDS YP_002342817.1 218768305 907885 1387161..1391051 1 NC_003116.1 NMA1491, mfd, transcription-repair coupling factor,len: 1296aa; similar to many eg. SW:P30958 (MFD_ECOLI) (1148 aa) fasta scores; E(): 0, 44.2% identity in 1305 aa overlap. Contains Pfam match to entry PF00270 DEAD,DEAD/DEAH box helicase and to entry PF00271 helicase_C,Helicases conserved C-terminal domain; transcription-repair coupling factor 1391051 907885 NMA1491 Neisseria meningitidis Z2491 transcription-repair coupling factor YP_002342817.1 1387161 D 122587 CDS YP_002342818.1 218768306 907886 1391200..1391583 1 NC_003116.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 1391583 panD 907886 panD Neisseria meningitidis Z2491 aspartate alpha-decarboxylase YP_002342818.1 1391200 D 122587 CDS YP_002342819.1 218768307 907887 1391605..1392447 1 NC_003116.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1392447 kdsA 907887 kdsA Neisseria meningitidis Z2491 2-dehydro-3-deoxyphosphooctonate aldolase YP_002342819.1 1391605 D 122587 CDS YP_002342820.1 218768308 907888 1392462..1392902 1 NC_003116.1 NMA1494, unknown, len: 146aa; N-terminal region similar to TR:O66525 (EMBL:AE000675) hypothetical protein (132 aa) fasta scores; E(): 0.005, 29.6% identity in 115 aa overlap.; hypothetical protein 1392902 907888 NMA1494 Neisseria meningitidis Z2491 hypothetical protein YP_002342820.1 1392462 D 122587 CDS YP_002342821.1 218768309 907889 1392950..1394236 1 NC_003116.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1394236 eno 907889 eno Neisseria meningitidis Z2491 phosphopyruvate hydratase YP_002342821.1 1392950 D 122587 CDS YP_002342822.1 218768310 907890 1394250..1394528 1 NC_003116.1 NMA1496, unknown, len: 92aa; similar to SW:Q46894 (YGBQ_ECOLI) hypothetical protein from Escherichia coli (103 aa) fasta scores; E(): 1.1e-10, 46.6% identity in 88 aa overlap.; hypothetical protein 1394528 907890 NMA1496 Neisseria meningitidis Z2491 hypothetical protein YP_002342822.1 1394250 D 122587 CDS YP_002342823.1 218768311 907891 complement(1394569..1394859) 1 NC_003116.1 NMA1497, iron-sulphur binding protein,len: 96aa; similar to SW:P37910 (YFAE_ECOLI) hypothetical protein from Escherichia coli (84 aa) fasta scores; E(): 4.2e-11, 45.8% identity in 83 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and Prosite match to PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.; iron-sulfur binding protein 1394859 907891 NMA1497 Neisseria meningitidis Z2491 iron-sulfur binding protein YP_002342823.1 1394569 R 122587 CDS YP_002342824.1 218768312 907892 complement(1395057..1396190) 1 NC_003116.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 1396190 nrdB 907892 nrdB Neisseria meningitidis Z2491 ribonucleotide-diphosphate reductase subunit beta YP_002342824.1 1395057 R 122587 CDS YP_002342825.1 218768313 907893 complement(1396251..1397438) 1 NC_003116.1 NMA1499, type-II restriction endonuclease,len: 395aa; similar to SW:P14633 (T2E2_ECOLI) restriction endonuclease EcoRII from Escherichia coli (404 aa) fasta scores; E(): 2.9e-29, 34.4% identity in 392 aa overlap.; type-II restriction endonuclease 1397438 907893 NMA1499 Neisseria meningitidis Z2491 type-II restriction endonuclease YP_002342825.1 1396251 R 122587 CDS YP_002342826.1 218768314 907894 complement(1397431..1398444) 1 NC_003116.1 NMA1500, probable modification methylase, len: 337aa; similar to many eg. SW:P05101 (MTS2_SHISO) modification methylase from Shigella sonnei (379 aa) fasta scores; E(): 0, 53.1% identity in 324 aa overlap. Contains Pfam match to entry PF00145 DNA_methylase, C-5 cytosine-specific DNA methylase and Prosite match to PS00095 C-5 cytosine-specific DNA methylases C-terminal signature and PS00094 C-5 cytosine-specific DNA methylases active site.; modification methylase 1398444 907894 NMA1500 Neisseria meningitidis Z2491 modification methylase YP_002342826.1 1397431 R 122587 CDS YP_002342827.1 218768315 907895 complement(1398502..1400781) 1 NC_003116.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1400781 nrdA 907895 nrdA Neisseria meningitidis Z2491 ribonucleotide-diphosphate reductase subunit alpha YP_002342827.1 1398502 R 122587 CDS YP_002342828.1 218768316 907896 1401310..1401621 1 NC_003116.1 NMA1503, unknown, len: 103aa; hypothetical protein 1401621 907896 NMA1503 Neisseria meningitidis Z2491 hypothetical protein YP_002342828.1 1401310 D 122587 CDS YP_002342829.1 218768317 907897 complement(1401933..1402700) 1 NC_003116.1 NMA1504, plsC, 1-acyl-SN-glycerol-3-phosphate acyltransferase, len: 255aa; similar to eg. TR:Q59618 (EMBL:U21807) plsC, 1-acyl-SN-glycerol-3-phosphate acyltransferase from Neisseria meningitidis serogroup B (257 aa) fasta scores; E(): 0, 97.3% identity in 257 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase. Contains membrane spanning hydrophobic regions.; 1-acyl-SN-glycerol-3-phosphate acyltransferase 1402700 907897 NMA1504 Neisseria meningitidis Z2491 1-acyl-SN-glycerol-3-phosphate acyltransferase YP_002342829.1 1401933 R 122587 CDS YP_002342830.1 218768318 907898 complement(1402788..1403615) 1 NC_003116.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1403615 907898 NMA1505 Neisseria meningitidis Z2491 formamidopyrimidine-DNA glycosylase YP_002342830.1 1402788 R 122587 CDS YP_002342831.1 218768319 907899 complement(1403667..1404332) 1 NC_003116.1 NMA1506, unknown, len: 221aa; hypothetical protein 1404332 907899 NMA1506 Neisseria meningitidis Z2491 hypothetical protein YP_002342831.1 1403667 R 122587 CDS YP_002342832.1 218768320 907900 1404510..1406486 1 NC_003116.1 NMA1507, membrane-bound lytic murein transglycosylase, len: 658aa; similar to SW:P23931 (MLTD_ECOLI) membrane-bound lytic murein transglycosylase D precursor from Escherichia coli (452 aa) fasta scores; E(): 5.8e-31, 33.3% identity in 399 aa overlap. Contains three Pfam matches to entry PF01476 PG_binding_2, peptidoglycan binding domain and Pfam match to entry PF01464 SLT, Transglycosylase SLT domain.; membrane bound murein transglycosylase 1406486 907900 NMA1507 Neisseria meningitidis Z2491 membrane bound murein transglycosylase YP_002342832.1 1404510 D 122587 CDS YP_002342833.1 218768321 907901 1406554..1407246 1 NC_003116.1 NMA1508, ribosomal small subunit pseudouridine synthase, len: 230aa; similar to many eg. SW:P33918 (RSUA_ECOLI) RsuA, ribosomal small subunit pseudouridine synthase A from Escherichia coli (231 aa) fasta scores; E(): 1.4e-21, 36.4% identity in 225 aa overlap. Contains Prosite match to PS01149 RsuA family of pseudouridine synthase signature.; ribosomal small subunit pseudouridine synthase 1407246 907901 NMA1508 Neisseria meningitidis Z2491 ribosomal small subunit pseudouridine synthase YP_002342833.1 1406554 D 122587 CDS YP_002342834.1 218768322 907903 1409433..1410089 1 NC_003116.1 NMA1514, cmk, cytidylate kinase, len: 218aa; similar to many eg. SW:P23863 (KCY_ECOLI) cmk, cytidylate kinase from Escherichia coli (227 aa) fasta scores; E(): 1.6e-30, 46.3% identity in 216 aa overlap; cytidylate kinase 1410089 907903 NMA1514 Neisseria meningitidis Z2491 cytidylate kinase YP_002342834.1 1409433 D 122587 CDS YP_002342835.1 218768323 907904 1410244..1411929 1 NC_003116.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1411929 rpsA 907904 rpsA Neisseria meningitidis Z2491 30S ribosomal protein S1 YP_002342835.1 1410244 D 122587 CDS YP_002342836.1 218768324 907905 1411940..1412254 1 NC_003116.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1412254 ihfB 907905 ihfB Neisseria meningitidis Z2491 integration host factor subunit beta YP_002342836.1 1411940 D 122587 CDS YP_002342837.1 218768325 907906 complement(1412605..1413012) 1 NC_003116.1 NMA1517, probable transcriptional regulator, len: 135aa; N-terminal region similar to many eg. SW:P22853 (MERR_BACSR) mercuric resistance operon regulator from Bacillus sp. (strain RC607) (132 aa) fasta scores; E(): 0.00031, 25.5% identity in 110 aa overlap. Also similar to SW:P44558 (Y186_HAEIN) hypothetical transcriptional regulator from Haemophilus influenzae (135 aa) fasta scores; E(): 0, 93.3% identity in 135 aa overlap. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and Prosite match to PS00552 Bacterial regulatory proteins, merR family signature. Also contains probable coiled-coil in the C-terminal region and helix-turn-helix 4-25aa (+3.80 SD).; transcriptional regulator 1413012 907906 NMA1517 Neisseria meningitidis Z2491 transcriptional regulator YP_002342837.1 1412605 R 122587 CDS YP_002342838.1 218768326 907907 1413133..1414269 1 NC_003116.1 NMA1518, adhC, alcohol dehydrogenase class-III,glutathione-dependent formaldehyde dehydrogenase, len: 378aa; similar to many eg. SW:P25437 (ADH3_ECOLI) adhC,alcohol dehydrogenase class-III from Escherichia coli (369 aa) fasta scores; E(): 0, 90.0% identity in 369 aa overlap. Contains Pfam match to entry PF00107 adh_zinc,Zinc-binding dehydrogenases and Prosite match to PS00059 Zinc-containing alcohol dehydrogenases signature.; alcohol dehydrogenase 1414269 907907 NMA1518 Neisseria meningitidis Z2491 alcohol dehydrogenase YP_002342838.1 1413133 D 122587 CDS YP_002342839.1 218768327 907908 1414278..1415105 1 NC_003116.1 NMA1519, esd, esterase D, len: 275aa; similar to SW:P10768 (ESTD_HUMAN) esd, esterase D from Homo sapiens (Human) (282 aa) fasta scores; E(): 0, 52.9% identity in 278 aa overlap. Also similar to SW:P44556 (YAIM_HAEIN) hypothetical protein from Haemophilus influenzae (275 aa) fasta scores; E(): 0, 95.3% identity in 275 aa overlap. Contains Pfam match to entry PF00756 Esterase, esterase.; esterase D 1415105 907908 NMA1519 Neisseria meningitidis Z2491 esterase D YP_002342839.1 1414278 D 122587 CDS YP_002342840.1 218768328 907909 1415498..1416649 1 NC_003116.1 NMA1520, nucleotide-binding protein, len: 383aa; similar to many of undefined function eg. SW:P46442 (YHCM_ECOLI) hypothetical protein from Escherichia coli (375 aa) fasta scores; E(): 0, 38.1% identity in 370 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; nucleotide-binding protein 1416649 907909 NMA1520 Neisseria meningitidis Z2491 nucleotide-binding protein YP_002342840.1 1415498 D 122587 CDS YP_002342841.1 218768329 907910 1416708..1417133 1 NC_003116.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1417133 ndk 907910 ndk Neisseria meningitidis Z2491 nucleoside diphosphate kinase YP_002342841.1 1416708 D 122587 CDS YP_002342842.1 218768330 907911 1417277..1418371 1 NC_003116.1 NMA1522, conserved hypothetical protein, len: 364aa; similar to many eg. SW:Q51385 (YFGB_PSEAE) hypothetical protein from Pseudomonas aeruginosa (379 aa) fasta scores; E(): 0, 57.9% identity in 356 aa overlap.; hypothetical protein 1418371 907911 NMA1522 Neisseria meningitidis Z2491 hypothetical protein YP_002342842.1 1417277 D 122587 CDS YP_002342843.1 218768331 907912 1418374..1419135 1 NC_003116.1 NMA1523, lipoprotein, len: 253aa; similar to TR:O67735 (EMBL:AE000762) hypothetical protein from Aquifex aeolicus (342 aa) fasta scores; E(): 3e-07, 29.7% identity in 195 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and uncleavable N-terminal signal sequence.; lipoprotein 1419135 907912 NMA1523 Neisseria meningitidis Z2491 lipoprotein YP_002342843.1 1418374 D 122587 CDS YP_002342844.1 218768332 907913 1419151..1420416 1 NC_003116.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1420416 ispG 907913 ispG Neisseria meningitidis Z2491 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_002342844.1 1419151 D 122587 CDS YP_002342845.1 218768333 907914 complement(1420469..1421083) 1 NC_003116.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1421083 clpP 907914 clpP Neisseria meningitidis Z2491 ATP-dependent Clp protease proteolytic subunit YP_002342845.1 1420469 R 122587 CDS YP_002342846.1 218768334 907915 complement(1421179..1422492) 1 NC_003116.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1422492 tig 907915 tig Neisseria meningitidis Z2491 trigger factor YP_002342846.1 1421179 R 122587 CDS YP_002342847.1 218768335 907916 complement(1422697..1425000) 1 NC_003116.1 NMA1527, ftsK-like cell division/stress response protein, len: 767aa; similar to many eg. TR:Q9Z3U1 (EMBL:AF095845) cell division/stress response protein from Pseudomonas syringae (801 aa) fasta scores; E(): 0, 44.7% identity in 774 aa overlap. Contains Pfam match to entry PF01580 FtsK_SpoIIIE and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; ftsK-like cell division/stress response protein 1425000 907916 NMA1527 Neisseria meningitidis Z2491 ftsK-like cell division/stress response protein YP_002342847.1 1422697 R 122587 CDS YP_002342848.1 218768336 907917 1425358..1426569 1 NC_003116.1 NMA1528, uraA, uracil permease, len: 403aa; similar to many eg. SW:P41006 (PYRP_BACCL) uracil permease from Bacillus caldolyticus (432 aa) fasta scores; E(): 0, 45.3% identity in 395 aa overlap. Contains Pfam match to entry PF00860 xan_ur_permease, Xanthine/uracil permeases family and Prosite match to PS01116 Xanthine/uracil permeases family signature. Also contains membrane spanning hydrophobic regions.; uracil permease 1426569 907917 NMA1528 Neisseria meningitidis Z2491 uracil permease YP_002342848.1 1425358 D 122587 CDS YP_002342849.1 218768337 907918 complement(1426621..1427103) 1 NC_003116.1 NMA1529, unknown, len: 160aa; hypothetical protein 1427103 907918 NMA1529 Neisseria meningitidis Z2491 hypothetical protein YP_002342849.1 1426621 R 122587 CDS YP_002342850.1 218768338 907920 1427686..1428432 1 NC_003116.1 NMA1532, pss, phosphatidylserine synthase, len: 248aa; similar to many eg. SW:Q48269 (PSS_HELPY) pss,phosphatidylserine synthase from Helicobacter pylori (237 aa) fasta scores; E(): 5.9e-21, 35.7% identity in 221 aa overlap. Contains Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature. Also contains membrane spanning hydrophobic regions.; phosphatidylserine synthase 1428432 907920 NMA1532 Neisseria meningitidis Z2491 phosphatidylserine synthase YP_002342850.1 1427686 D 122587 CDS YP_002342851.1 218768339 907921 1428433..1429239 1 NC_003116.1 NMA1533, conserved hypothetical integral membrane protein, len: 268aa; similar to many eg. SW:P44070 (Y902_HAEIN) hypothetical protein from Haemophilus influenzae (264 aa) fasta scores; E(): 5.1e-23, 33.7% identity in 261 aa overlap. Contains membrane spanning hydrophobic regions.; hypothetical protein 1429239 907921 NMA1533 Neisseria meningitidis Z2491 hypothetical protein YP_002342851.1 1428433 D 122587 CDS YP_002342852.1 218768340 907922 complement(1430027..1430479) 1 NC_003116.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 1430479 rplI 907922 rplI Neisseria meningitidis Z2491 50S ribosomal protein L9 YP_002342852.1 1430027 R 122587 CDS YP_002342853.1 218768341 907923 complement(1430496..1430726) 1 NC_003116.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1430726 rpsR 907923 rpsR Neisseria meningitidis Z2491 30S ribosomal protein S18 YP_002342853.1 1430496 R 122587 CDS YP_002342854.1 218768342 907924 complement(1430733..1431035) 1 NC_003116.1 NMA1536, priB, primosomal replication protein, len: 100aa; similar to many eg. SW:P07013 (PRIB_ECOLI) priB,primosomal replication protein N from Escherichia coli (103 aa) fasta scores; E(): 0.016, 31.2% identity in 77 aa overlap.; primosomal replication protein 1431035 907924 NMA1536 Neisseria meningitidis Z2491 primosomal replication protein YP_002342854.1 1430733 R 122587 CDS YP_002342855.1 218768343 907925 complement(1431036..1431404) 1 NC_003116.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1431404 rpsF 907925 rpsF Neisseria meningitidis Z2491 30S ribosomal protein S6 YP_002342855.1 1431036 R 122587 CDS YP_002342856.1 218768344 907926 complement(1431560..1432510) 1 NC_003116.1 NMA1538, trxB, thioredoxin reductase, len: 316aa; similar to many eg. SW:P09625 (TRXB_ECOLI) trxB,thioredoxin reductase from Escherichia coli (320 aa) fasta scores; E(): 0, 66.7% identity in 312 aa overlap. Contains Prosite match to PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site.; thioredoxin reductase 1432510 907926 NMA1538 Neisseria meningitidis Z2491 thioredoxin reductase YP_002342856.1 1431560 R 122587 CDS YP_002342857.1 218768345 907927 1432649..1434826 1 NC_003116.1 NMA1539, probable cation-transporting ATPase, len: 725aa; similar to many eg. SW:P32113 (COPA_ENTHR) copper/potassium-transporting ATPase A from Enterococcus hirae (834 aa) fasta scores; E(): 0, 40.7% identity in 732 aa overlap. Contains Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPases, Pfam match to entry PF00403 HMA, Heavy-metal-associated domain, Prosite match to PS01047 Heavy-metal-associated domain and Prosite match to PS00154 E1-E2 ATPases phosphorylation site. Also contains membrane spanning hydrophobic regions.; cation-transporting ATPase 1434826 907927 NMA1539 Neisseria meningitidis Z2491 cation-transporting ATPase YP_002342857.1 1432649 D 122587 CDS YP_002342858.1 218768346 907928 1434881..1436767 1 NC_003116.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1436767 uvrC 907928 uvrC Neisseria meningitidis Z2491 excinuclease ABC subunit C YP_002342858.1 1434881 D 122587 CDS YP_002342859.1 218768347 907929 1437010..1438443 1 NC_003116.1 NMA1541, unknown, len: 477aa; hypothetical protein 1438443 907929 NMA1541 Neisseria meningitidis Z2491 hypothetical protein YP_002342859.1 1437010 D 122587 CDS YP_002342860.1 218768348 907930 1438565..1439281 1 NC_003116.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 1439281 trmB 907930 trmB Neisseria meningitidis Z2491 tRNA (guanine-N(7)-)-methyltransferase YP_002342860.1 1438565 D 122587 CDS YP_002342861.1 218768349 907931 1439484..1440086 1 NC_003116.1 NMA1543, Insertion element IS1016 transposase, len: 200aa; similar to many eg. TR:Q48208 (EMBL:X58176) from a compound transposon in Haemophilus influenzae (164 aa) fasta scores; E(): 0, 69.6% identity in 161 aa overlap. Similar to others from Neisseria meningitidis eg. NMA1956,fasta scores; E(): 0, 97.5% identity in 200 aa overlap.; Insertion element IS1016 transposase 1440086 907931 NMA1543 Neisseria meningitidis Z2491 Insertion element IS1016 transposase YP_002342861.1 1439484 D 122587 CDS YP_002342862.1 218768350 907932 complement(1440251..1441015) 1 NC_003116.1 NMA1544, unknown, len: 254aa; lies in a region of unusually low GC content, some N-terminal similarity to TR:AAD38961 (EMBL:AF147978) hypothetical protein from Pseudomonas aeruginosa Bacteriophage D3 (170 aa) fasta scores; E(): 0.00049, 31.5% identity in 111 aa overlap.; hypothetical protein 1441015 907932 NMA1544 Neisseria meningitidis Z2491 hypothetical protein YP_002342862.1 1440251 R 122587 CDS YP_002342863.1 218768351 907933 complement(1441083..1443110) 1 NC_003116.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1443110 uvrB 907933 uvrB Neisseria meningitidis Z2491 excinuclease ABC subunit B YP_002342863.1 1441083 R 122587 CDS YP_002342864.1 218768352 907934 complement(1443439..1444923) 1 NC_003116.1 NMA1546, carboxy-terminal processing protease, len: 494aa; similar to many eg. TR:Q44879 (EMBL:L37094) carboxy-terminal processing protease from Bartonella bacilliformis (434 aa) fasta scores; E(): 0,41.5% identity in 455 aa overlap. Contains Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF).; carboxy-terminal processing protease 1444923 907934 NMA1546 Neisseria meningitidis Z2491 carboxy-terminal processing protease YP_002342864.1 1443439 R 122587 CDS YP_002342865.1 218768353 907935 complement(1445043..1446848) 1 NC_003116.1 NMA1547, secreted lysine-rich protein, peptidase function, len: 601aa; contains probable N-terminal signal sequence and extensive coiled-coil regions and is largely hydrophilic. Also contains Pfam match to entry PF01551 Peptidase_M37.; hypothetical protein 1446848 907935 NMA1547 Neisseria meningitidis Z2491 hypothetical protein YP_002342865.1 1445043 R 122587 CDS YP_002342866.1 218768354 907937 1447176..1447736 1 NC_003116.1 NMA1549, lipoprotein, function unknown,len: 186aa; similar to SW:P08367 (CREA_ECOLI) hypothetical protein from Escherichia coli fasta scores; E(): 1.5e-21,45.9% identity in 146 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; hypothetical protein 1447736 907937 NMA1549 Neisseria meningitidis Z2491 hypothetical protein YP_002342866.1 1447176 D 122587 CDS YP_002342867.1 218768355 907938 1447738..1448286 1 NC_003116.1 NMA1550, conserved hypothetical protein, function unknown, len: 182aa; similar to several eg. SW:P52049 (YQGE_ECOLI) hypothetical protein from Escherichia coli (187 aa) fasta scores; E(): 3.2e-31, 44.1% identity in 188 aa overlap.; hypothetical protein 1448286 907938 NMA1550 Neisseria meningitidis Z2491 hypothetical protein YP_002342867.1 1447738 D 122587 CDS YP_002342868.1 218768356 907939 1448279..1448734 1 NC_003116.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 1448734 907939 NMA1551 Neisseria meningitidis Z2491 Holliday junction resolvase-like protein YP_002342868.1 1448279 D 122587 CDS YP_002342869.1 218768357 907940 complement(1448744..1449400) 1 NC_003116.1 NMA1552, hydrolase, len: 218aa; similar to the C-terminal region of TR:Q46978 (EMBL:Z37980) OPET decarboxylase from Escherichia coli (429 aa) fasta scores; E(): 1.4e-13, 30.7% identity in 199 aa overlap. Also similar to many of undefined function particularly TR:Q9ZHI3 (EMBL:AF061446) hypothetical protein from Chromobacterium violaceum (138 aa) fasta scores; E(): 3.5e-26, 56.2% identity in 137 aa overlap. Contains Pfam match to entry PF01557 FAA_hydrolase.; hydrolase 1449400 907940 NMA1552 Neisseria meningitidis Z2491 hydrolase YP_002342869.1 1448744 R 122587 CDS YP_002342870.1 218768358 907941 complement(1449464..1451176) 1 NC_003116.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1451176 proS 907941 proS Neisseria meningitidis Z2491 prolyl-tRNA synthetase YP_002342870.1 1449464 R 122587 CDS YP_002342871.1 218768359 907942 1451870..1454533 1 NC_003116.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1454533 aceE 907942 aceE Neisseria meningitidis Z2491 pyruvate dehydrogenase subunit E1 YP_002342871.1 1451870 D 122587 CDS YP_002342872.1 218768360 907943 1454683..1456290 1 NC_003116.1 NMA1555, aceF, dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, len: 535aa; similar to many eg. SW:P06959 (ODP2_ECOLI) aceF,dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex from Escherichia coli (629 aa) fasta scores; E(): 0, 56.5% identity in 536 aa overlap. Contains two Pfam matches to entry PF00364 biotin_lipoyl,Biotin-requiring enzymes, Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and two Prosite matches to PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.; dihydrolipoamide acetyltransferase 1456290 aceF 907943 aceF Neisseria meningitidis Z2491 dihydrolipoamide acetyltransferase YP_002342872.1 1454683 D 122587 CDS YP_002342873.1 218768361 907944 1456368..1458152 1 NC_003116.1 NMA1556, lpdA, dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes), len: 594aa; similar to many eg. SW:P00391 (DLDH_ECOLI) lpdA, dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes) from Escherichia coli (473 aa) fasta scores; E(): 0, 63.8% identity in 486 aa overlap. Also similar to TR:Q51188 (EMBL:X84696) from Neisseria meningitidis (594 aa) fasta scores; E(): 0, 97.0% identity in 594 aa overlap. Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes; Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase class-I; Prosite match to PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site and Prosite match to PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site.; dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes) 1458152 907944 NMA1556 Neisseria meningitidis Z2491 dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes) YP_002342873.1 1456368 D 122587 CDS YP_002342874.1 218768362 907945 complement(1458513..1460051) 1 NC_003116.1 NMA1557, unknown, len: 512aa; hypothetical protein 1460051 907945 NMA1557 Neisseria meningitidis Z2491 hypothetical protein YP_002342874.1 1458513 R 122587 CDS YP_002342875.1 218768363 907946 complement(1460188..1462308) 1 NC_003116.1 NMA1558, TonB-dependent receptor protein,len: 706aa; weakly similar to many TonB-dependent receptor proteins eg. SW:P11461 (FATA_VIBAN) ferric anguibactin receptor precursor from Vibrio anguillarum (726 aa) fasta scores; E(): 8.2e-19, 25.5% identity in 722 aa overlap. Contains Pfam match to entry PF00593 TonB_boxC, TonB dependent receptor C-terminal region.; TonB-dependent receptor protein 1462308 907946 NMA1558 Neisseria meningitidis Z2491 TonB-dependent receptor protein YP_002342875.1 1460188 R 122587 CDS YP_002342876.1 218768364 907947 complement(1462567..1463352) 1 NC_003116.1 NMA1559, inositol monophosphate family protein,function unknown, len: 261aa; similar to many other inositol monophosphate family proteins eg. SW:P22783 (SUHB_ECOLI) extragenic suppressor protein from Escherichia coli (267 aa) fasta scores; E(): 0, 44.1% identity in 254 aa overlap. Contains Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family; Prosite match to PS00629 Inositol monophosphatase family signature 1 and Prosite match to PS00630 Inositol monophosphatase family signature 2.; inositol monophosphate family protein 1463352 907947 NMA1559 Neisseria meningitidis Z2491 inositol monophosphate family protein YP_002342876.1 1462567 R 122587 CDS YP_002342877.1 218768365 907948 1463533..1464411 1 NC_003116.1 NMA1560, SpoU methylase family protein, len: 292aa; similar to many others of undefined function which carry a Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family eg. TR:P77438 (EMBL:AE000339) hypothetical protein from Escherichia coli (246 aa) fasta scores; E(): 2.7e-17, 36.2% identity in 260 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family.; SpoU methylase family protein 1464411 907948 NMA1560 Neisseria meningitidis Z2491 SpoU methylase family protein YP_002342877.1 1463533 D 122587 CDS YP_002342878.1 218768366 907949 1464451..1465329 1 NC_003116.1 NMA1561, unknown, len: 292aa; hypothetical protein 1465329 907949 NMA1561 Neisseria meningitidis Z2491 hypothetical protein YP_002342878.1 1464451 D 122587 CDS YP_002342879.1 218768367 907950 1465533..1465874 1 NC_003116.1 NMA1562, unknown, len: 113aa; lies in a region of unusually low GC content.; hypothetical protein 1465874 907950 NMA1562 Neisseria meningitidis Z2491 hypothetical protein YP_002342879.1 1465533 D 122587 CDS YP_002342880.1 218768368 907951 1466222..1467478 1 NC_003116.1 NMA1563, Sun-family protein, len: 418aa; C-terminal similar to many other SUN-family proteins eg. SW:P36929 (SUN_ECOLI) Sun protein from Escherichia coli (429 aa) fasta scores; E(): 1.3e-24, 32.6% identity in 356 aa overlap. Contains Pfam match to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family.; SUN-family protein 1467478 907951 NMA1563 Neisseria meningitidis Z2491 SUN-family protein YP_002342880.1 1466222 D 122587 CDS YP_002342881.1 218768369 907952 1468234..1468668 1 NC_003116.1 NMA1564, unknown, len: 144aa; contains probable coiled-coil in the C-terminal region.; hypothetical protein 1468668 907952 NMA1564 Neisseria meningitidis Z2491 hypothetical protein YP_002342881.1 1468234 D 122587 CDS YP_002342882.1 218768370 907953 complement(1468716..1470059) 1 NC_003116.1 NMA1565, probable aldehyde dehydrogenase, len: 447aa; similar to many eg. SW:P71016 (DHAB_BACSU) betaine aldehyde dehydrogenase from Bacillus subtilis (490 aa) fasta scores; E(): 0, 33.8% identity in 420 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase and Prosite match to PS00070 Aldehyde dehydrogenases cysteine active site.; aldehyde dehydrogenase 1470059 907953 NMA1565 Neisseria meningitidis Z2491 aldehyde dehydrogenase YP_002342882.1 1468716 R 122587 CDS YP_002342883.1 218768371 907954 complement(1470064..1470777) 1 NC_003116.1 NMA1566, conserved hypothetical protein, len: 237aa; similar to many eg. SW:P25743 (YCHE_ECOLI) hypothetical protein from Escherichia coli (215 aa) fasta scores; E(): 1.2e-20, 33.3% identity in 207 aa overlap.; hypothetical protein 1470777 907954 NMA1566 Neisseria meningitidis Z2491 hypothetical protein YP_002342883.1 1470064 R 122587 CDS YP_002342884.1 218768372 907955 1470868..1471158 1 NC_003116.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 1471158 gatC 907955 gatC Neisseria meningitidis Z2491 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_002342884.1 1470868 D 122587 CDS YP_002342885.1 218768373 907956 1471221..1472666 1 NC_003116.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 1472666 gatA 907956 gatA Neisseria meningitidis Z2491 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_002342885.1 1471221 D 122587 CDS YP_002342886.1 218768374 907957 1472663..1473595 1 NC_003116.1 NMA1569, membrane protein, len: 310aa; similar to SW:Q57273 (YB19_HAEIN) hypothetical protein from Haemophilus influenzae (292 aa) fasta scores; E(): 1.9e-32, 37.6% identity in 295 aa overlap. Contains membrane spanning hydrophobic regions.; membrane protein 1473595 907957 NMA1569 Neisseria meningitidis Z2491 membrane protein YP_002342886.1 1472663 D 122587 CDS YP_002342887.1 218768375 907958 1473638..1475068 1 NC_003116.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1475068 gatB 907958 gatB Neisseria meningitidis Z2491 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_002342887.1 1473638 D 122587 CDS YP_002342888.1 218768376 907959 1475160..1476170 1 NC_003116.1 NMA1571, iron/sulphur-binding oxidoreductase, len: 336aa; similar to many eg. SW:P37911 (ASCD_YERPS) CDP-6-deoxy-delta-3,4-glucoseen reductase from Yersinia pseudotuberculosis (328 aa) fasta scores; E(): 0, 40.4% identity in 329 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains; Pfam match to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain and Prosite match to PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.; iron/sulfur-binding oxidoreductase 1476170 907959 NMA1571 Neisseria meningitidis Z2491 iron/sulfur-binding oxidoreductase YP_002342888.1 1475160 D 122587 CDS YP_002342889.1 218768377 907960 complement(1476300..1476932) 1 NC_003116.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1476932 pdxH 907960 pdxH Neisseria meningitidis Z2491 pyridoxamine 5'-phosphate oxidase YP_002342889.1 1476300 R 122587 CDS YP_002342890.1 218768378 907961 1477432..1478202 1 NC_003116.1 NMA1573, pseudouridine synthase, len: 256aa; similar to SW:P35159 (RLUB_BACSU) large subunit pseudouridine synthase B from Bacillus subtilis (229 aa) fasta scores; E(): 1e-21, 39.1% identity in 235 aa overlap. Also similar to many hypothetical proteins eg. SW:P37765 (YCIL_ECOLI) hypothetical protein from Escherichia coli (291 aa) fasta scores; E(): 0, 51.2% identity in 256 aa overlap. Contains Pfam match to entry PF01479 S4, S4 domain and Prosite match to PS01149 RsuA family of pseudouridine synthase signature.; pseudouridine synthase 1478202 907961 NMA1573 Neisseria meningitidis Z2491 pseudouridine synthase YP_002342890.1 1477432 D 122587 CDS YP_002342891.1 218768379 907962 complement(1478271..1479812) 1 NC_003116.1 NMA1574, integral membrane transporter,len: 513aa; weakly similar to several monocarboxylate transporters (eukaryote) eg. SW:P53986 (MOT1_MOUSE) monocarboxylate transporter from Mus musculus (Mouse) (493 aa) fasta scores; E(): 5.7e-10, 23.8% identity in 479 aa overlap. Also similar to TR:Q9ZBV5 (EMBL:AL034443) integral membrane transporter from Streptomyces coelicolor (446 aa) fasta scores; E(): 0, 50.1% identity in 463 aa overlap.; integral membrane transporter 1479812 907962 NMA1574 Neisseria meningitidis Z2491 integral membrane transporter YP_002342891.1 1478271 R 122587 CDS YP_002342892.1 218768380 907963 complement(1481025..1482380) 1 NC_003116.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1482380 xseA 907963 xseA Neisseria meningitidis Z2491 exodeoxyribonuclease VII large subunit YP_002342892.1 1481025 R 122587 CDS YP_002342893.1 218768381 907964 1482577..1483398 1 NC_003116.1 NMA1576, nadE, NH(3)-dependent NAD synthetase, len: 273aa; similar to many egs. SW:Q58747 (NADE_METJA) probable NH(3)-dependent NAD synthetase from Methanococcus jannaschii (259 aa) fasta scores; E(): 3.9e-22, 35.1% identity in 259 aa overlap and SW:P08164 (NADE_BACSU) NH(3)-dependent NAD synthetase from Bacillus subtilis (272 aa) fasta scores; E(): 4.8e-15, 31.8% identity in 236 aa overlap.; NH(3)-dependent NAD synthetase 1483398 907964 NMA1576 Neisseria meningitidis Z2491 NH(3)-dependent NAD synthetase YP_002342893.1 1482577 D 122587 CDS YP_002342894.1 218768382 907965 complement(1483468..1483941) 1 NC_003116.1 NMA1577, unknown, len: 157aa; similar to SW:P39313 (YTFE_ECOLI) hypothetical protein from Escherichia coli (220 aa) fasta scores; E(): 3.7e-26, 45.7% identity in 151 aa overlap.; hypothetical protein 1483941 907965 NMA1577 Neisseria meningitidis Z2491 hypothetical protein YP_002342894.1 1483468 R 122587 CDS YP_002342895.1 218768383 907966 1484244..1484576 1 NC_003116.1 NMA1578, trxA, thioredoxin I, len: 129aa; similar to many eg. SW:P00274 (THIO_ECOLI) trxA, thioredoxin I from Escherichia coli (108 aa) fasta scores; E(): 9.1e-27,61.1% identity in 108 aa overlap. Contains Pfam match to entry PF00085 thiored, Thioredoxin and Prosite match to PS00194 Thioredoxin family active site.; thioredoxin I 1484576 907966 NMA1578 Neisseria meningitidis Z2491 thioredoxin I YP_002342895.1 1484244 D 122587 CDS YP_002342896.1 218768384 907967 complement(1484629..1485576) 1 NC_003116.1 NMA1579, unknown, len: 315aa; similar to the C-terminal region of many eg. SW:P44524 (YCBY_HAEIN) hypothetical protein from Haemophilus influenzae (711 aa) fasta scores; E(): 0, 48.4% identity in 316 aa overlap.; hypothetical protein 1485576 907967 NMA1579 Neisseria meningitidis Z2491 hypothetical protein YP_002342896.1 1484629 R 122587 CDS YP_002342897.1 218768385 907968 1485904..1487292 1 NC_003116.1 NMA1580, probable ATP-dependent RNA helicase, len: 462aa; similar to many eg. SW:P25888 (RHLE_ECOLI) RhlE, ATP-dependent RNA helicase from Escherichia coli (454 aa) fasta scores; E(): 0, 44.0% identity in 466 aa overlap. Contains Pfam match to entry PF00270 DEAD,DEAD/DEAH box helicase; Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain; Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00039 DEAD-box subfamily ATP-dependent helicases signature.; ATP-dependent RNA helicase 1487292 907968 NMA1580 Neisseria meningitidis Z2491 ATP-dependent RNA helicase YP_002342897.1 1485904 D 122587 CDS YP_002342898.1 218768386 907969 complement(1487937..1488491) 1 NC_003116.1 NMA1581, membrane lipoprotein, len: 184aa; contains N-terminal signal sequence, a membrane spanning hydrophobic region and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site; membrane lipoprotein 1488491 907969 NMA1581 Neisseria meningitidis Z2491 membrane lipoprotein YP_002342898.1 1487937 R 122587 CDS YP_002342899.1 218768387 907970 complement(1488576..1489136) 1 NC_003116.1 NMA1582, unknown, len: 186aa; hypothetical protein 1489136 907970 NMA1582 Neisseria meningitidis Z2491 hypothetical protein YP_002342899.1 1488576 R 122587 CDS YP_002342900.1 218768388 907972 1489480..1490673 1 NC_003116.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase 1490673 argD 907972 argD Neisseria meningitidis Z2491 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase YP_002342900.1 1489480 D 122587 CDS YP_002342901.1 218768389 907973 complement(1490738..1491982) 1 NC_003116.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1491982 clpX 907973 clpX Neisseria meningitidis Z2491 ATP-dependent protease ATP-binding subunit ClpX YP_002342901.1 1490738 R 122587 CDS YP_002342902.1 218768390 907974 1492173..1492544 1 NC_003116.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 1492544 rbfA 907974 rbfA Neisseria meningitidis Z2491 ribosome-binding factor A YP_002342902.1 1492173 D 122587 CDS YP_002342903.1 218768391 907975 1492534..1493079 1 NC_003116.1 NMA1587, unknown, len: 543aa; hypothetical protein 1493079 907975 NMA1587 Neisseria meningitidis Z2491 hypothetical protein YP_002342903.1 1492534 D 122587 CDS YP_002342904.1 218768392 907976 1493137..1494057 1 NC_003116.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1494057 truB 907976 truB Neisseria meningitidis Z2491 tRNA pseudouridine synthase B YP_002342904.1 1493137 D 122587 CDS YP_002342905.1 218768393 907979 1496471..1499293 1 NC_003116.1 NMA1591, type III restriction/modification system enzyme, len: 940aa; lies alongside a probable modification methylase. C-terminal similar to that from SW:P08764 (T3RE_BPP1) type III restriction/modification system EcoP1 restriction enzyme (970 aa) fasta scores; E(): 0.0039, 22.3% identity in 412 aa overlap. Also highly similar to TR:Q9ZHV5 (EMBL:AF048762) from Neisseria meningitidis (965 aa) fasta scores; E(): 0, 100.0% identity in 933 aa overlap. Lies in a DNA region of unusually low GC content.; type III restriction/modification system enzyme 1499293 907979 NMA1591 Neisseria meningitidis Z2491 type III restriction/modification system enzyme YP_002342905.1 1496471 D 122587 CDS YP_002342906.1 218768394 907980 complement(1499437..1500609) 1 NC_003116.1 NMA1592, lldA, L-lactate dehydrogenase, len: 390aa; almost identical to TR:Q51135 (EMBL:U58911) lldA,L-lactate dehydrogenase from Neisseria meningitidis (390 aa) fasta scores; E(): 0, 99.7% identity in 390 aa overlap. Contains Pfam match to entry PF01070 FMN_dh,FMN-dependent dehydrogenase and Prosite match to PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site.; L-lactate dehydrogenase 1500609 907980 NMA1592 Neisseria meningitidis Z2491 L-lactate dehydrogenase YP_002342906.1 1499437 R 122587 CDS YP_002342907.1 218768395 907981 1500899..1501345 1 NC_003116.1 NMA1593, conserved hypothetical DNA-binding protein, len: 148aa; similar to many egs. SW:P77484 (YFHP_ECOLI) hypothetical protein from Escherichia coli (162 aa) fasta scores; E(): 1.8e-26,50.7% identity in 146 aa overlap and SW:Q51134 (YLDA_NEIME) hypothetical protein from Neisseria meningitidis (150 aa) fasta scores; E(): 0, 98.5% identity in 131 aa overlap. Contains helix-turn-helix 27-48aa (+2.63 SD).; DNA-binding protein 1501345 907981 NMA1593 Neisseria meningitidis Z2491 DNA-binding protein YP_002342907.1 1500899 D 122587 CDS YP_002342908.1 218768396 907982 1501374..1502588 1 NC_003116.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 1502588 907982 NMA1594 Neisseria meningitidis Z2491 cysteine desulfurase YP_002342908.1 1501374 D 122587 CDS YP_002342909.1 218768397 907984 1502849..1503235 1 NC_003116.1 NMA1596, NifU-like protein, len: 128aa; similar to many eg. TR:P77310 (EMBL:AE000339) NifU protein from Escherichia coli (128 aa) fasta scores; E(): 0, 84.4% identity in 128 aa overlap. Contains Pfam match to entry PF01592 NifU_N.; scaffold protein 1503235 907984 NMA1596 Neisseria meningitidis Z2491 scaffold protein YP_002342909.1 1502849 D 122587 CDS YP_002342910.1 218768398 907985 1503322..1503642 1 NC_003116.1 NMA1597, HesB-like protein, len: 106aa; similar to many HesB-like proteins eg. SW:P36539 (YFHF_ECOLI) hypothetical protein from Escherichia coli (107 aa) fasta scores; E(): 1.2e-27, 66.7% identity in 105 aa overlap. Contains Pfam match to entry PF01521 HesB-like and Prosite match to PS01152 Hypothetical hesB/yadR/yfhF family signature.; HesB-like protein 1503642 907985 NMA1597 Neisseria meningitidis Z2491 HesB-like protein YP_002342910.1 1503322 D 122587 CDS YP_002342911.1 218768399 907986 1503905..1504405 1 NC_003116.1 NMA1598, hscB, chaperone protein, len: 166aa; similar to many eg. SW:P36540 (HSCB_ECOLI) hscB, chaperone protein from Escherichia coli (171 aa) fasta scores; E(): 3.2e-17, 41.3% identity in 160 aa overlap. Contains Pfam match to entry PF00226 DnaJ, DnaJ domain.; chaperone protein 1504405 907986 NMA1598 Neisseria meningitidis Z2491 chaperone protein YP_002342911.1 1503905 D 122587 CDS YP_002342912.1 218768400 907987 1504503..1507253 1 NC_003116.1 NMA1599, gyrA, DNA gyrase subunit A, len: 916aa; similar to many eg. SW:P48371 (GYRA_NEIGO) gyrA, DNA gyrase subunit A from Neisseria gonorrhoeae (916 aa) fasta scores; E(): 0, 97.3% identity in 916 aa overlap. Contains Pfam match to entry PF00521 DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A.; DNA gyrase subunit A 1507253 907987 NMA1599 Neisseria meningitidis Z2491 DNA gyrase subunit A YP_002342912.1 1504503 D 122587 CDS YP_002342913.1 218768401 907988 1507410..1507814 1 NC_003116.1 NMA1600, transposase, len: 134aa; similar to (but missing a central 82aa portion) TR:Q9ZIX7 (EMBL:AF007429) transposase from Haemophilus gallinarum (216 aa) fasta scores; E(): 4.3e-22, 51.6% identity in 215 aa overlap. Contains helix-turn-helix 23-44aa (+3.20 SD).; transposase 1507814 907988 NMA1600 Neisseria meningitidis Z2491 transposase YP_002342913.1 1507410 D 122587 CDS YP_002342914.1 218768402 907993 complement(1508859..1509410) 1 NC_003116.1 NMA1603, unknown, len: 183aa; contains probable coiled-coil regions.; hypothetical protein 1509410 907993 NMA1603 Neisseria meningitidis Z2491 hypothetical protein YP_002342914.1 1508859 R 122587 CDS YP_002342915.1 218768403 907994 complement(1509424..1511070) 1 NC_003116.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1511070 pgi 907994 pgi Neisseria meningitidis Z2491 glucose-6-phosphate isomerase YP_002342915.1 1509424 R 122587 CDS YP_002342916.1 218768404 907995 complement(1511191..1512039) 1 NC_003116.1 NMA1605, probable transcriptional regulator, len: 282aa; weakly similar to SW:P39266 (RPIR_ECOLI) Als operon repressor from Escherichia coli (296 aa) fasta scores; E(): 9.2e-21, 27.9% identity in 258 aa overlap. Also similar to many hypothetical proteins eg. SW:P46118 (YEBK_ECOLI) hypothetical protein from Escherichia coli (289 aa) fasta scores; E(): 0, 42.1% identity in 278 aa overlap. Contains Pfam match to entry PF01380 SIS, SIS domain; Pfam match to entry PF01418 HTH_6,Helix-turn-helix domain, rpiR family and Prosite match to PS00356 Bacterial regulatory proteins, lacI family signature.; transcriptional regulator 1512039 907995 NMA1605 Neisseria meningitidis Z2491 transcriptional regulator YP_002342916.1 1511191 R 122587 CDS YP_002342917.1 218768405 907996 complement(1512089..1513075) 1 NC_003116.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 1513075 glk 907996 glk Neisseria meningitidis Z2491 glucokinase YP_002342917.1 1512089 R 122587 CDS YP_002342918.1 218768406 907997 complement(1513056..1513751) 1 NC_003116.1 NMA1608, pgl, 6-phosphogluconolactonase, len: 231aa; similar to TR:AAD22666 (EMBL:AF029673) pgl,6-phosphogluconolactonase from Pseudomonas aeruginosa (243 aa) fasta scores; E(): 2.9e-26, 41.7% identity in 218 aa overlap.; 6-phosphogluconolactonase 1513751 907997 NMA1608 Neisseria meningitidis Z2491 6-phosphogluconolactonase YP_002342918.1 1513056 R 122587 CDS YP_002342919.1 218768407 907998 complement(1514031..1515476) 1 NC_003116.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1515476 zwf 907998 zwf Neisseria meningitidis Z2491 glucose-6-phosphate 1-dehydrogenase YP_002342919.1 1514031 R 122587 CDS YP_002342920.1 218768408 907999 1516094..1517929 1 NC_003116.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1517929 edd 907999 edd Neisseria meningitidis Z2491 phosphogluconate dehydratase YP_002342920.1 1516094 D 122587 CDS YP_002342921.1 218768409 908000 1518110..1518748 1 NC_003116.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1518748 eda 908000 eda Neisseria meningitidis Z2491 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_002342921.1 1518110 D 122587 CDS YP_002342922.1 218768410 908003 1520242..1521291 1 NC_003116.1 NMA1614, mutY, adenine glycosylase, len: 349aa; similar to many eg. SW:P17802 (MUTY_ECOLI) mutY, adenine glycosylase from Escherichia coli (350 aa) fasta scores; E(): 0, 44.6% identity in 343 aa overlap. Also almost identical to TR:Q9ZF41 (EMBL:AJ001313) mutY, adenine glycosylase from Neisseria meningitidis (346 aa) fasta scores; E(): 0, 99.7% identity in 346 aa overlap. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III and Prosite match to PS00764 Endonuclease III iron-sulfur binding region signature.; adenine glycosylase 1521291 908003 NMA1614 Neisseria meningitidis Z2491 adenine glycosylase YP_002342922.1 1520242 D 122587 CDS YP_002342923.1 218768411 908005 1521454..1521636 1 NC_003116.1 NMA1616, unknown, len: 60aa; hypothetical protein 1521636 908005 NMA1616 Neisseria meningitidis Z2491 hypothetical protein YP_002342923.1 1521454 D 122587 CDS YP_002342924.1 218768412 908006 1521708..1522268 1 NC_003116.1 NMA1617, sodC, superoxide dismutase, len: 186aa; almost identical to SW:Q59623 (SODC_NEIME) sodC,superoxide dismutase from Neisseria meningitidis (186 aa) fasta scores; E(): 0, 99.5% identity in 186 aa overlap. Probably located in the periplasmic space. Contains Pfam match to entry PF00080 sodcu, Copper/zinc superoxide dismutase (SODC) and Prosite match to PS00332 Copper/Zinc superoxide dismutase signature 2.; superoxide dismutase 1522268 908006 NMA1617 Neisseria meningitidis Z2491 superoxide dismutase YP_002342924.1 1521708 D 122587 CDS YP_002342925.1 218768413 908009 complement(1523857..1526085) 1 NC_003116.1 NMA1620, probable cytolysin secretion ABC transporter, len: 742aa; similar to many involved in cytolysin secretion eg. SW:P26760 (RT1B_ACTPL) RTX-1 toxin secretion ATP-binding protein from Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae) (707 aa) fasta scores; E(): 0, 72.7% identity in 699 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter; Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region; Prosite match to PS00211 ABC transporters family signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; cytolysin secretion ABC transporter 1526085 908009 NMA1620 Neisseria meningitidis Z2491 cytolysin secretion ABC transporter YP_002342925.1 1523857 R 122587 CDS YP_002342926.1 218768414 908010 complement(1526885..1527424) 1 NC_003116.1 NMA1621, insertion element IS1016 transposase, len: 179aa; similar to many eg. TR:Q48234 (EMBL:X59756) IS1016 insertion sequence from Haemophilus influenzae (191 aa) fasta scores; E(): 0, 72.6% identity in 175 aa overlap. Similar to others from Neisseria meningitidis eg. NMA2185,fasta scores; E(): 0, 92.7% identity in 179 aa overlap.; insertion element IS1016 transposase 1527424 908010 NMA1621 Neisseria meningitidis Z2491 insertion element IS1016 transposase YP_002342926.1 1526885 R 122587 CDS YP_002342927.1 218768415 908011 1527761..1528195 1 NC_003116.1 NMA1622, unknown, len: 144aa; lies in a region of unusually low GC content.; hypothetical protein 1528195 908011 NMA1622 Neisseria meningitidis Z2491 hypothetical protein YP_002342927.1 1527761 D 122587 CDS YP_002342928.1 218768416 908012 1528206..1528427 1 NC_003116.1 NMA1623, unknown, len: 73aa; lies in a region of unusually low GC content.; hypothetical protein 1528427 908012 NMA1623 Neisseria meningitidis Z2491 hypothetical protein YP_002342928.1 1528206 D 122587 CDS YP_002342929.1 218768417 908013 1528462..1529190 1 NC_003116.1 NMA1624, integral membrane protein, len: 242aa; contains membrane spanning hydrophobic regions. Lies in a region of unusually low GC content.; integral membrane protein 1529190 908013 NMA1624 Neisseria meningitidis Z2491 integral membrane protein YP_002342929.1 1528462 D 122587 CDS YP_002342930.1 218768418 908014 1529177..1530229 1 NC_003116.1 NMA1625, probable RTX-family exoprotein, len: 350aa; similar to regions of Neisseria meningitidis iron-regulated proteins egs. N-terminal region of SW:P55127 (FRPC_NEIME) FrpC (1829 aa) fasta scores; E(): 0, 78.8% identity in 146 aa overlap and N-terminal region of SW:P55126 (FRPA_NEIME) FrpA (1115 aa) fasta scores; E(): 0, 41.6% identity in 394 aa overlap. Contains a membrane spanning hydrophobic region.; RTX family exoprotein 1530229 908014 NMA1625 Neisseria meningitidis Z2491 RTX family exoprotein YP_002342930.1 1529177 D 122587 CDS YP_002342931.1 218768419 908015 1530284..1532377 1 NC_003116.1 NMA1626, probable RTX-family exoprotein, len: 697aa; similar to regions of other RTX-family proteins particularly C-terminal region of SW:P55126 (FRPA_NEIME) iron-regulated protein from Neisseria meningitidis (1115 aa) fasta scores; E(): 0, 99.1% identity in 697 aa overlap and C-terminal region of SW:P55127 (FRPC_NEIME) iron-regulated protein from Neisseria meningitidis (1829 aa) fasta scores; E(): 0, 88.0% identity in 685 aa overlap. Contains three Pfam matches to entry PF00353 hemolysinCabind, Hemolysin-type calcium-binding proteins and three Prosite matches to PS00330 Hemolysin-type calcium-binding region signature.; RTX-family exoprotein 1532377 908015 NMA1626 Neisseria meningitidis Z2491 RTX-family exoprotein YP_002342931.1 1530284 D 122587 CDS YP_002342932.1 218768420 908016 complement(1532719..1535322) 1 NC_003116.1 NMA1627, pepN, aminopeptidase N, len: 867aa; similar to many eg. SW:P04825 (AMPN_ECOLI) pepN,aminopeptidase N from Escherichia coli (869 aa) fasta scores; E(): 0, 48.4% identity in 868 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1, Peptidase family M1 and Prosite match to PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.; aminopeptidase 1535322 pepN 908016 pepN Neisseria meningitidis Z2491 aminopeptidase YP_002342932.1 1532719 R 122587 CDS YP_002342933.1 218768421 908017 complement(1535458..1536252) 1 NC_003116.1 NMA1628, unknown, len: 264aa; similar to TR:Q9ZLF2 (EMBL:AE001495) hypothetical protein from Helicobacter pylori J99 (276 aa) fasta scores; E(): 1.6e-15, 26.0% identity in 273 aa overlap.; hypothetical protein 1536252 908017 NMA1628 Neisseria meningitidis Z2491 hypothetical protein YP_002342933.1 1535458 R 122587 CDS YP_002342934.1 218768422 908019 complement(1537001..1537870) 1 NC_003116.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1537870 908019 NMA1630 Neisseria meningitidis Z2491 lipid A biosynthesis lauroyl acyltransferase YP_002342934.1 1537001 R 122587 CDS YP_002342935.1 218768423 908020 complement(1537921..1538457) 1 NC_003116.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1538457 ruvC 908020 ruvC Neisseria meningitidis Z2491 Holliday junction resolvase YP_002342935.1 1537921 R 122587 CDS YP_002342936.1 218768424 908021 complement(1538460..1538699) 1 NC_003116.1 NMA1632, fis, factor-for-inversion-stimulation protein, len: 79aa; similar to many eg. SW:P11028 (FIS_ECOLI) fis, factor-for-inversion-stimulation protein from Escherichia coli (98 aa) fasta scores; E(): 0, 44.0% identity in 75 aa overlap. Contains probable DNA-binding helix-turn-helix motif (+3.80 SD) 54-75aa. Also contains Pfam match to entry PF00158 sigma54, Sigma-54 transcription factors.; DNA-binding protein Fis 1538699 908021 NMA1632 Neisseria meningitidis Z2491 DNA-binding protein Fis YP_002342936.1 1538460 R 122587 CDS YP_002342937.1 218768425 908022 complement(1538729..1539739) 1 NC_003116.1 NMA1633, conserved hypothetical protein, len: 336aa; similar to many eg. SW:P25717 (YHDG_ECOLI) hypothetical protein from Escherichia coli (321 aa) fasta scores; E(): 0, 53.3% identity in 321 aa overlap. Contains Pfam match to entry PF01207 UPF0034, Uncharacterized protein family UPF0034 and Prosite match to PS01136 Uncharacterized protein family UPF0034 signature.; hypothetical protein 1539739 908022 NMA1633 Neisseria meningitidis Z2491 hypothetical protein YP_002342937.1 1538729 R 122587 CDS YP_002342938.1 218768426 908023 1540105..1541478 1 NC_003116.1 NMA1634, probable ATP-dependent RNA helicase, len: 457aa; similar to many eg. SW:P25888 (RHLE_ECOLI) ATP-dependent RNA helicase from Escherichia coli (454 aa) fasta scores; E(): 0, 46.2% identity in 457 aa overlap. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase; Pfam match to entry PF00271 helicase_C,Helicases conserved C-terminal domain; Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00039 DEAD-box subfamily ATP-dependent helicases signature.; ATP-dependent RNA helicase 1541478 908023 NMA1634 Neisseria meningitidis Z2491 ATP-dependent RNA helicase YP_002342938.1 1540105 D 122587 CDS YP_002342939.1 218768427 908024 1542053..1543180 1 NC_003116.1 NMA1635, unknown, len: 375aa; hypothetical protein 1543180 908024 NMA1635 Neisseria meningitidis Z2491 hypothetical protein YP_002342939.1 1542053 D 122587 CDS YP_002342940.1 218768428 908025 1543210..1544088 1 NC_003116.1 NMA1636, unknown, len: 292aa; hypothetical protein 1544088 908025 NMA1636 Neisseria meningitidis Z2491 hypothetical protein YP_002342940.1 1543210 D 122587 CDS YP_002342941.1 218768429 908027 complement(1544506..1546017) 1 NC_003116.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 1546017 lysS 908027 lysS Neisseria meningitidis Z2491 lysyl-tRNA synthetase YP_002342941.1 1544506 R 122587 CDS YP_002342942.1 218768430 908028 complement(1546172..1547425) 1 NC_003116.1 NMA1639, probable integral membrane protein, len: 417aa; contains probable membrane spanning hydrophobic regions.; integral membrane protein 1547425 908028 NMA1639 Neisseria meningitidis Z2491 integral membrane protein YP_002342942.1 1546172 R 122587 CDS YP_002342943.1 218768431 908029 1547699..1549678 1 NC_003116.1 NMA1640, aminopeptidase, len: 659aa; weakly similar to many both prokaryote and eukaryote eg. TR:Q95333 (EMBL:U55039) aminopeptidase P from Sus scrofa (Pig) (673 aa) fasta scores; E(): 0, 34.8% identity in 632 aa overlap. Contains Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24.; aminopeptidase 1549678 908029 NMA1640 Neisseria meningitidis Z2491 aminopeptidase YP_002342943.1 1547699 D 122587 CDS YP_002342944.1 218768432 908030 complement(1550999..1551820) 1 NC_003116.1 NMA1641, probable insertion element IS1106 transposase, len: 273aa; similar to many transposases particularly SW:Q00840 (TRA6_NEIME) insertion element IS1106 transposase from Neisseria meningitidis (288 aa) fasta scores; E(): 0, 80.8% identity in 265 aa overlap.; insertion element IS1106 transposase 1551820 908030 NMA1641 Neisseria meningitidis Z2491 insertion element IS1106 transposase YP_002342944.1 1550999 R 122587 CDS YP_002342945.1 218768433 908031 complement(1552433..1553620) 1 NC_003116.1 NMA1642, porA, porin, class I outer membrane protein, len: 395aa; highly similar to many eg. TR:Q51240 (EMBL:X52995) porA, class I outer membrane protein from Neisseria meningitidis (392 aa) fasta scores; E(): 0,95.7% identity in 395 aa overlap. Contains Pfam match to entry PF00267 Gram-ve_porins, General diffusion Gram-negative porins and Prosite match to PS00576 General diffusion Gram-negative porins signature. Also similar to NM398, porB (43.7% identity in 398 aa overlap); porin 1553620 908031 NMA1642 Neisseria meningitidis Z2491 porin YP_002342945.1 1552433 R 122587 CDS YP_002342946.1 218768434 908032 complement(1556634..1557110) 1 NC_003116.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1557110 greA 908032 greA Neisseria meningitidis Z2491 transcription elongation factor GreA YP_002342946.1 1556634 R 122587 CDS YP_002342947.1 218768435 908033 1557502..1558803 1 NC_003116.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1558803 aroA 908033 aroA Neisseria meningitidis Z2491 3-phosphoshikimate 1-carboxyvinyltransferase YP_002342947.1 1557502 D 122587 CDS YP_002342948.1 218768436 908034 complement(1558846..1559379) 1 NC_003116.1 NMA1645, lipoprotein, len: 177aa; similar to many over a specific region which corresponds to a conserved domain of unknown function found in lipoproteins eg. SW:Q47151 (YAFL_ECOLI) hypothetical lipoprotein from Escherichia coli (249 aa) fasta scores; E(): 0, 37.2% identity in 156 aa overlap. Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein 1559379 908034 NMA1645 Neisseria meningitidis Z2491 lipoprotein YP_002342948.1 1558846 R 122587 CDS YP_002342949.1 218768437 908035 complement(1559588..1561165) 1 NC_003116.1 NMA1646, phopholipase D-family protein, len: 525aa; similar to many of undefined function eg. SW:P75919 (YMDC_ECOLI) hypothetical protein from Escherichia coli (493 aa) fasta scores; E(): 0, 48.7% identity in 460 aa overlap. Contains two Pfam matches to entry PF00614 PLDc,Phospholipase D. Active site motif. Also contains a membrane spanning hydrophobic region.; phopholipase D-family protein 1561165 908035 NMA1646 Neisseria meningitidis Z2491 phopholipase D-family protein YP_002342949.1 1559588 R 122587 CDS YP_002342950.1 218768438 908036 complement(1561226..1562767) 1 NC_003116.1 NMA1647, probable integral membrane protein, len: 513aa; similar to many with membrane spanning hydrophobic regions eg. SW:P31474 (YIEO_ECOLI) hypothetical protein from Escherichia coli (475 aa) fasta scores; E(): 0, 43.0% identity in 451 aa overlap. Contains membrane spanning hydrophobic regions.; integral membrane protein 1562767 908036 NMA1647 Neisseria meningitidis Z2491 integral membrane protein YP_002342950.1 1561226 R 122587 CDS YP_002342951.1 218768439 908037 1562916..1563695 1 NC_003116.1 NMA1648, conserved hypothetical protein, len: 259aa; similar to others of undefined function eg. TR:O24951 (EMBL:AE000535) conserved hypothetical secreted protein from Helicobacter pylori (242 aa) fasta scores; E(): 0, 40.8% identity in 240 aa overlap.; hypothetical protein 1563695 908037 NMA1648 Neisseria meningitidis Z2491 hypothetical protein YP_002342951.1 1562916 D 122587 CDS YP_002342952.1 218768440 908038 1563692..1564393 1 NC_003116.1 NMA1649, conserved hypothetical protein, len: 233aa; similar to TR:O24949 (EMBL:AE000535) hypothetical protein from Helicobacter pylori (211 aa) fasta scores; E(): 1.9e-11, 29.0% identity in 217 aa overlap.; hypothetical protein 1564393 908038 NMA1649 Neisseria meningitidis Z2491 hypothetical protein YP_002342952.1 1563692 D 122587 CDS YP_002342953.1 218768441 908039 1564390..1565844 1 NC_003116.1 NMA1650, conserved hypothetical iron-sulphur protein, len: 484aa; similar to many eg. TR:O24950 (EMBL:AE000535) conserved hypothetical iron-sulphur protein from Helicobacter pylori (481 aa) fasta scores; E(): 0, 44.4% identity in 450 aa overlap. Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and two Prosite matches to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.; Fe-S protein 1565844 908039 NMA1650 Neisseria meningitidis Z2491 Fe-S protein YP_002342953.1 1564390 D 122587 CDS YP_002342954.1 218768442 908040 complement(1566027..1566512) 1 NC_003116.1 NMA1651, purE, phosphoribosylaminoimidazole carboxylase catalytic subunit, len: 161aa; similar to many eg. SW:P12044 (PUR6_BACSU) purE,phosphoribosylaminoimidazole (162 aa) fasta scores; E(): 0, 66.2% identity in 151 aa overlap. Contains Pfam match to entry PF00731 AIRC, AIR carboxylase, score 300.10,E-value 2.8e-86.; phosphoribosylaminoimidazole carboxylase catalytic subunit 1566512 908040 NMA1651 Neisseria meningitidis Z2491 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_002342954.1 1566027 R 122587 CDS YP_002342955.1 218768443 908041 complement(1566560..1567276) 1 NC_003116.1 NMA1652, periplasmic protein, len: 238aa; contains N-terminal signal sequence. Also contains probable coiled-coil region.; hypothetical protein 1567276 908041 NMA1652 Neisseria meningitidis Z2491 hypothetical protein YP_002342955.1 1566560 R 122587 CDS YP_002342956.1 218768444 908042 complement(1567276..1567944) 1 NC_003116.1 NMA1653, methyltransferase, len: 222aa; similar to many methyltransferases egs. TR:Q50859 (EMBL:U24657) O-methyltransferase from DNA-binding antibiotic biosynthesis cluster of Myxococcus xanthus (220 aa) fasta scores; E(): 2.4e-26, 39.3% identity in 219 aa overlap. Contains Pfam match to entry PF01596 Methyltransf_3.; methyltransferase 1567944 908042 NMA1653 Neisseria meningitidis Z2491 methyltransferase YP_002342956.1 1567276 R 122587 CDS YP_002342957.1 218768445 908044 1568283..1570259 1 NC_003116.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 1570259 mutL 908044 mutL Neisseria meningitidis Z2491 DNA mismatch repair protein YP_002342957.1 1568283 D 122587 CDS YP_002342958.1 218768446 908045 1570354..1572483 1 NC_003116.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 1572483 dnaZX 908045 dnaZX Neisseria meningitidis Z2491 DNA polymerase III subunits gamma and tau YP_002342958.1 1570354 D 122587 CDS YP_002342959.1 218768447 908046 1572563..1572898 1 NC_003116.1 NMA1657, conserved hypothetical protein, len: 111aa; similar to many eg. SW:P44711 (YBAB_HAEIN) hypothetical protein from Haemophilus influenzae (109 aa) fasta scores; E(): 4.8e-19, 58.3% identity in 108 aa overlap. Contains probable coiled-coil region towards the N-terminus.; hypothetical protein 1572898 908046 NMA1657 Neisseria meningitidis Z2491 hypothetical protein YP_002342959.1 1572563 D 122587 CDS YP_002342960.1 218768448 908047 complement(1574167..1575213) 1 NC_003116.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1575213 recA 908047 recA Neisseria meningitidis Z2491 recombinase A YP_002342960.1 1574167 R 122587 CDS YP_002342961.1 218768449 908048 1575434..1576231 1 NC_003116.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1576231 aroD 908048 aroD Neisseria meningitidis Z2491 3-dehydroquinate dehydratase YP_002342961.1 1575434 D 122587 CDS YP_002342962.1 218768450 908049 1576251..1578266 1 NC_003116.1 NMA1660, rep, ATP-dependent DNA helicase, len: 671aa; similar to many eg. SW:P09980 (REP_ECOLI) rep,ATP-deepndent DNA helicase from Escherichia coli (673 aa) fasta scores; E(): 0, 48.1% identity in 669 aa overlap. Contains Pfam match to entry PF00580 UvrD-helicase,UvrD/REP helicase and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; ATP-dependent DNA helicase 1578266 908049 NMA1660 Neisseria meningitidis Z2491 ATP-dependent DNA helicase YP_002342962.1 1576251 D 122587 CDS YP_002342963.1 218768451 908050 complement(1578334..1579392) 1 NC_003116.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1579392 908050 NMA1661 Neisseria meningitidis Z2491 DNA polymerase IV YP_002342963.1 1578334 R 122587 CDS YP_002342964.1 218768452 908053 1583002..1583781 1 NC_003116.1 NMA1664, probable ferredoxin NADP+ reductase, len: 259aa; similar to many ferredoxin NADP+ reductases eg. SW:P28861 (FENR_ECOLI) ferredoxin NADP+ reductase from Escherichia coli (247 aa) fasta scores; E(): 3.7e-22,32.3% identity in 254 aa overlap. Contains Pfam match to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain.; ferredoxin NADP+ reductase 1583781 908053 NMA1664 Neisseria meningitidis Z2491 ferredoxin NADP+ reductase YP_002342964.1 1583002 D 122587 CDS YP_002342965.1 218768453 908054 complement(1583992..1585404) 1 NC_003116.1 NMA1665, DNA polymerase III subunit, len: 470aa; similar to many eg. the central region of SW:P13267 (DPO3_BACSU) DNA polymerase III alpha chain from Bacillus subtilis (1437 aa) fasta scores; E(): 1.1e-11, 30.6% identity in 170 aa overlap. Contains Pfam match to entry PF00929 Exonuclease, Exonuclease.; DNA polymerase III subunit 1585404 908054 NMA1665 Neisseria meningitidis Z2491 DNA polymerase III subunit YP_002342965.1 1583992 R 122587 CDS YP_002342966.1 218768454 908055 1586222..1587397 1 NC_003116.1 NMA1666, unknown, len: 391aa; similar to TR:O25465 (EMBL:AE000589) hypothetical protein from Helicobacter pylori (363 aa) fasta scores; E(): 1.2e-23, 30.7% identity in 387 aa overlap.; hypothetical protein 1587397 908055 NMA1666 Neisseria meningitidis Z2491 hypothetical protein YP_002342966.1 1586222 D 122587 CDS YP_002342967.1 218768455 908056 complement(1587457..1588005) 1 NC_003116.1 NMA1667, inner membrane protein, len: 182aa; contains a membrane spanning hydrophobic region close to the N-terminus.; inner membrane protein 1588005 908056 NMA1667 Neisseria meningitidis Z2491 inner membrane protein YP_002342967.1 1587457 R 122587 CDS YP_002342968.1 218768456 908057 complement(1588008..1589504) 1 NC_003116.1 NMA1668, ferredoxin, len: 498aa; similar to many ferredoxin-like proteins eg. SW:P18396 (FIXG_RHIME) FixG from Rhizobium meliloti (524 aa) fasta scores; E(): 0, 33.8% identity in 461 aa overlap. Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. Contains membrane spanning hydrophobic regions.; ferredoxin 1589504 908057 NMA1668 Neisseria meningitidis Z2491 ferredoxin YP_002342968.1 1588008 R 122587 CDS YP_002342969.1 218768457 908058 1590031..1592010 1 NC_003116.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1592010 tkt 908058 tkt Neisseria meningitidis Z2491 transketolase YP_002342969.1 1590031 D 122587 CDS YP_002342970.1 218768458 908059 1592151..1593539 1 NC_003116.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1593539 fumC 908059 fumC Neisseria meningitidis Z2491 fumarate hydratase YP_002342970.1 1592151 D 122587 CDS YP_002342971.1 218768459 908060 complement(1593604..1594527) 1 NC_003116.1 NMA1671, conserved hypothetical protein, len: 307aa; similar to many eg. SW:P71360 (YHBE_HAEIN) hypothetical protein from Haemophilus influenzae (306 aa) fasta scores; E(): 0, 48.2% identity in 307 aa overlap. Contains two Pfam matches to entry PF00892 DUF6, Integral membrane protein.; hypothetical protein 1594527 908060 NMA1671 Neisseria meningitidis Z2491 hypothetical protein YP_002342971.1 1593604 R 122587 CDS YP_002342972.1 218768460 908061 complement(1594899..1595423) 1 NC_003116.1 NMA1672, ssb, single-stranded binding protein, len: 174aa; similar to many eg. SW:P02339 (SSB_ECOLI) ssb,single-stranded binding protein from Escherichia coli (177 aa) fasta scores; E(): 1.3e-22, 48.1% identity in 181 aa overlap. Contains Pfam match to entry PF00436 SSB,Single-strand binding protein family; Prosite match to PS00736 Single-strand binding protein family signature 2 and Prosite match to PS00735 Single-strand binding protein family signature 1.; ssDNA-binding protein 1595423 908061 NMA1672 Neisseria meningitidis Z2491 ssDNA-binding protein YP_002342972.1 1594899 R 122587 CDS YP_002342973.1 218768461 908062 complement(1595427..1596812) 1 NC_003116.1 NMA1673, probable integral membrane transporter,len: 461aa; similar to many proposed membrane transporters eg. TR:O67276 (EMBL:AE000729) transporter (major facilitator family) from Aquifex aeolicus (392 aa) fasta scores; E(): 0, 41.6% identity in 382 aa overlap. Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter and Prosite match to PS00216 Sugar transport proteins signature 1. Also contains probable membrane spanning hydrophobic regions.; integral membrane transporter 1596812 908062 NMA1673 Neisseria meningitidis Z2491 integral membrane transporter YP_002342973.1 1595427 R 122587 CDS YP_002342974.1 218768462 908063 complement(1596920..1597543) 1 NC_003116.1 NMA1674, transglycosylase, len: 207aa; regions of weak similarity to many eg. SW:P03810 (SLT_ECOLI) soluble lytic murein transglycosylase precursor from Escherichia coli (645 aa) fasta scores; E(): 0.1, 27.7% identity in 141 aa overlap. Contains Pfam match to entry PF01464 SLT, Transglycosylase SLT domain.; transglycosylase 1597543 908063 NMA1674 Neisseria meningitidis Z2491 transglycosylase YP_002342974.1 1596920 R 122587 CDS YP_002342975.1 218768463 908064 complement(1598453..1598869) 1 NC_003116.1 NMA1675, conserved hypothetical protein, len: 138aa; similar to others eg. SW:Q47152 (YAFM_ECOLI) hypothetical protein from Escherichia coli (165 aa) fasta scores; E(): 9.6e-30, 52.0% identity in 127 aa overlap. Also highly similar to NMA0532 form another region of the Neisseria meningitidis chromosome (138 aa) fasta scores; E(): 0, 99.3% identity in 138 aa overlap. Lies within a region of unusually low GC content.; hypothetical protein 1598869 908064 NMA1675 Neisseria meningitidis Z2491 hypothetical protein YP_002342975.1 1598453 R 122587 CDS YP_002342976.1 218768464 908068 1601826..1603334 1 NC_003116.1 NMA1679, ppx/gppA, exopolyphosphatase, len: 502aa; similar to many exophosphatases including SW:P29014 (PPX_ECOLI) ppx, exopolyphosphatase from Escherichia coli (512 aa) fasta scores; E(): 0, 36.5% identity in 501 aa overlap and SW:P25552 (GPPA_ECOLI) guanosine pentaphosphate phosphohydrolase from Escherichia coli (494 aa) fasta scores; E(): 0, 34.3% identity in 499 aa overlap.; exopolyphosphatase 1603334 908068 NMA1679 Neisseria meningitidis Z2491 exopolyphosphatase YP_002342976.1 1601826 D 122587 CDS YP_002342977.1 218768465 908070 complement(1604187..1604528) 1 NC_003116.1 NMA1681, unknown, len: 113aa; hypothetical protein 1604528 908070 NMA1681 Neisseria meningitidis Z2491 hypothetical protein YP_002342977.1 1604187 R 122587 CDS YP_002342978.1 218768466 908071 complement(1604534..1605544) 1 NC_003116.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1605544 trpS 908071 trpS Neisseria meningitidis Z2491 tryptophanyl-tRNA synthetase YP_002342978.1 1604534 R 122587 CDS YP_002342979.1 218768467 908072 1605805..1608384 1 NC_003116.1 NMA1683, clpB, ClpB protein, len: 859aa; similar to many eg. SW:P03815 (CLPB_ECOLI) ClpB protein (ATPase subunit of clp protease) from Escherichia coli (857 aa) fasta scores; E(): 0, 66.4% identity in 857 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B; two Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop); Prosite match to PS00870 Chaperonins clpA/B signature 1 and Prosite match to PS00871 Chaperonins clpA/B signature 2. Also contains coiled-coil regions.; ClpB protein 1608384 908072 NMA1683 Neisseria meningitidis Z2491 ClpB protein YP_002342979.1 1605805 D 122587 CDS YP_002342980.1 218768468 908073 complement(1608471..1609685) 1 NC_003116.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 1609685 908073 NMA1684 Neisseria meningitidis Z2491 aminotransferase YP_002342980.1 1608471 R 122587 CDS YP_002342981.1 218768469 908074 complement(1609774..1609983) 1 NC_003116.1 NMA1685, tautomerase, len: 69aa; similar to many eg. SW:P49172 (DMPI_PSESP) 4-oxalocrotonate tautomerase from Pseudomonas sp. (strain CF600) (62 aa) fasta scores; E(): 0.32, 32.3% identity in 65 aa overlap. Also similar to SW:P45418 (YKDK_ERWCH) hypothetical protein from Erwinia chrysanthemi (73 aa) fasta scores; E(): 2.2e-15, 65.7% identity in 67 aa overlap. Contains Pfam match to entry PF01361 Tautomerase, Tautomerase enzyme.; tautomerase 1609983 908074 NMA1685 Neisseria meningitidis Z2491 tautomerase YP_002342981.1 1609774 R 122587 CDS YP_002342982.1 218768470 908075 1610328..1611134 1 NC_003116.1 NMA1686, periplasmic protein, len: 268aa; similar to SW:P44196 (YE27_HAEIN) hypothetical protein from Haemophilus influenzae (278 aa) fasta scores; E(): 0,44.6% identity in 269 aa overlap. Seems to have a cleavable N-term signal seq.; hypothetical protein 1611134 908075 NMA1686 Neisseria meningitidis Z2491 hypothetical protein YP_002342982.1 1610328 D 122587 CDS YP_002342983.1 218768471 908076 complement(1611192..1612457) 1 NC_003116.1 NMA1687, probable glutamate dehydrogenase, len: 421aa; similar to many eg. SW:P27346 (DHE2_CLODI) NAD-specific glutamate dehydrogenase (421 aa) fasta scores; E(): 0, 56.6% identity in 422 aa overlap. Contains Pfam match to entry PF00208 GLFV_dehydrog,Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; and Prosite match to PS00074 Glu / Leu / Phe / Val dehydrogenases active site.; glutamate dehydrogenase 1612457 908076 NMA1687 Neisseria meningitidis Z2491 glutamate dehydrogenase YP_002342983.1 1611192 R 122587 CDS YP_002342984.1 218768472 908077 1612864..1613571 1 NC_003116.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 1613571 908077 NMA1688 Neisseria meningitidis Z2491 phosphoglycolate phosphatase YP_002342984.1 1612864 D 122587 CDS YP_002342985.1 218768473 908078 1613639..1614100 1 NC_003116.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1614100 recX 908078 recX Neisseria meningitidis Z2491 recombination regulator RecX YP_002342985.1 1613639 D 122587 CDS YP_002342986.1 218768474 908080 1614488..1614970 1 NC_003116.1 NMA1691, acyl-CoA hydrolase, len: 160aa; weakly similar to the N-terminal region of TR:O08652 (EMBL:D88891) acyl-CoA hydrolase from Rattus norvegicus (Rat) (343 aa) fasta scores; E(): 1.7e-10, 32.2% identity in 152 aa overlap. Also similar to SW:O05729 (VDLD_HELPY) VdlD protein from Helicobacter pylori (174 aa) fasta scores; E(): 5.1e-30, 56.5% identity in 138 aa overlap. Contains Pfam match to entry PF01662 Acyl-CoA_hydro.; acyl-CoA hydrolase 1614970 908080 NMA1691 Neisseria meningitidis Z2491 acyl-CoA hydrolase YP_002342986.1 1614488 D 122587 CDS YP_002342987.1 218768475 908081 complement(1615331..1616578) 1 NC_003116.1 NMA1692, membrane peptidase, len: 415aa; similar to the C-terminal region of proposed lipoproteins eg. SW:P33648 (NLPD_ECOLI) lipoprotein from Escherichia coli (379 aa) fasta scores; E(): 3.3e-16, 36.4% identity in 321 aa overlap. Also similar to SW:P44833 (LPPB_HAEIN) outer membrane antigenic lipoprotein from Haemophilus influenzae (405 aa) fasta scores; E(): 1.4e-14, 30.5% identity in 446 aa overlap. Contains Pfam match to entry PF01551 Peptidase_M37, peptidoglycan binding domain; Pfam match to entry PF01476 PG_binding_2, peptidoglycan binding domain; Pfam match to entry PF01476 PG_binding_2, peptidoglycan binding domain and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; membrane peptidase 1616578 908081 NMA1692 Neisseria meningitidis Z2491 membrane peptidase YP_002342987.1 1615331 R 122587 CDS YP_002342988.1 218768476 908082 complement(1616681..1617427) 1 NC_003116.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 1617427 surE 908082 surE Neisseria meningitidis Z2491 stationary phase survival protein SurE YP_002342988.1 1616681 R 122587 CDS YP_002342989.1 218768477 908083 complement(1617444..1619000) 1 NC_003116.1 NMA1694, conserved hypothetical integral membrane protein, len: 526aa; similar to many hypothetical proteins eg. SW:P76262 (YOAE_ECOLI) hypothetical protein from Escherichia coli (518 aa) fasta scores; E(): 0, 46.4% identity in 521 aa overlap. Contains two Pfam match to entry PF00571 CBS, CBS domain and probable membrane spanning hydrophobic regions.; hypothetical protein 1619000 908083 NMA1694 Neisseria meningitidis Z2491 hypothetical protein YP_002342989.1 1617444 R 122587 CDS YP_002342990.1 218768478 908084 complement(1619368..1620156) 1 NC_003116.1 NMA1695, fimbrial assembly protein, len: 262aa; similar to several fimbrial assembly proteins SW:P17834 (FMBI_BACNO) fimbrial assembly protein from Bacteroides nodosus (257 aa) fasta scores; E(): 0, 39.0% identity in 254 aa overlap.; fimbrial assembly protein 1620156 908084 NMA1695 Neisseria meningitidis Z2491 fimbrial assembly protein YP_002342990.1 1619368 R 122587 CDS YP_002342991.1 218768479 908085 complement(1620265..1621698) 1 NC_003116.1 NMA1696, gabD, succinate semialdehyde dehydrogenase, len: 477aa; similar to many eg. SW:P25526 (GABD_ECOLI) gabD, succinate semialdehyde dehydrogenase from Escherichia coli (482 aa) fasta scores; E(): 0, 61.5% identity in 455 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase; Prosite match to PS00070 Aldehyde dehydrogenases cysteine active site and Prosite match to PS00687 Aldehyde dehydrogenases glutamic acid active site.; succinate semialdehyde dehydrogenase 1621698 908085 NMA1696 Neisseria meningitidis Z2491 succinate semialdehyde dehydrogenase YP_002342991.1 1620265 R 122587 CDS YP_002342992.1 218768480 908086 complement(1622362..1622742) 1 NC_003116.1 NMA1697, lipoprotein, len: 126aa; contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 1622742 908086 NMA1697 Neisseria meningitidis Z2491 lipoprotein YP_002342992.1 1622362 R 122587 CDS YP_002342993.1 218768481 908087 1623218..1625299 1 NC_003116.1 NMA1698, probable integral membrane protein (CstA-like), len: 693aa; strongly similar to SW:P15078 (CSTA_ECOLI) CstA, carbon starvation protein from Escherichia coli (701 aa) fasta scores; E(): 0, 62.1% identity in 683 aa overlap. Contains probable membrane-spanning hydrophobic regions.; integral membrane protein (CstA-like) 1625299 908087 NMA1698 Neisseria meningitidis Z2491 integral membrane protein (CstA-like) YP_002342993.1 1623218 D 122587 CDS YP_002342994.1 218768482 908089 1627036..1629804 1 NC_003116.1 NMA1700, outer membrane substrate binding protein, len: 922aa; weakly similar to several transferrin-binding proteins from Neisseria meningitidis eg. SW:Q06987 (TB12_NEIME) transferrin-binding protein (908 aa) fasta scores; E(): 1.9e-07, 23.5% identity in 833 aa overlap. Also similar to SW:P45114 (YC17_HAEIN) probable TonB receptor protein from Haemophilus influenzae (913 aa) fasta scores; E(): 0, 52.4% identity in 931 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS01156 TonB-dependent receptor proteins signature 2. Also contains a N-terminal signal sequence.; outer membrane substrate binding protein 1629804 908089 NMA1700 Neisseria meningitidis Z2491 outer membrane substrate binding protein YP_002342994.1 1627036 D 122587 CDS YP_002342995.1 218768483 908090 complement(1630967..1632184) 1 NC_003116.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 1632184 lysC 908090 lysC Neisseria meningitidis Z2491 aspartate kinase YP_002342995.1 1630967 R 122587 CDS YP_002342996.1 218768484 908091 complement(1632386..1633114) 1 NC_003116.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1633114 rph 908091 rph Neisseria meningitidis Z2491 ribonuclease PH YP_002342996.1 1632386 R 122587 CDS YP_002342997.1 218768485 908092 complement(1633196..1633660) 1 NC_003116.1 NMA1703, conserved hypothetical protein, len: 154aa; similar to many eg. TR:O06153 (EMBL:Z95554) hypothetical protein from Mycobacterium tuberculosis (146 aa) fasta scores; E(): 9.3e-10, 34.5% identity in 148 aa overlap. Contains Pfam match to entry PF00582 Usp,Universal stress protein family.; hypothetical protein 1633660 908092 NMA1703 Neisseria meningitidis Z2491 hypothetical protein YP_002342997.1 1633196 R 122587 CDS YP_002342998.1 218768486 908093 1633877..1634653 1 NC_003116.1 NMA1704, conserved hypothetical protein, len: 258aa; similar to SW:Q46927 (YGDL_ECOLI) hypothetical protein from Escherichia coli (268 aa) fasta scores; E(): 0, 50.6% identity in 253 aa overlap. Contains Pfam match to entry PF00899 ThiF_family, ThiF family.; hypothetical protein 1634653 908093 NMA1704 Neisseria meningitidis Z2491 hypothetical protein YP_002342998.1 1633877 D 122587 CDS YP_002342999.1 218768487 908094 1634898..1635752 1 NC_003116.1 NMA1705, unknown, len: 284aa; similar to many hypothetical proteins eg. SW:P35154 (YPUG_BACSU) hypothetical protein from Bacillus subtilis (251 aa) fasta scores; E(): 2.4e-16, 40.5% identity in 247 aa overlap.; hypothetical protein 1635752 908094 NMA1705 Neisseria meningitidis Z2491 hypothetical protein YP_002342999.1 1634898 D 122587 CDS YP_002343000.1 218768488 908095 1635742..1637001 1 NC_003116.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1637001 pncB 908095 pncB Neisseria meningitidis Z2491 nicotinate phosphoribosyltransferase YP_002343000.1 1635742 D 122587 CDS YP_002343001.1 218768489 908096 1637093..1638811 1 NC_003116.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1638811 argS 908096 argS Neisseria meningitidis Z2491 arginyl-tRNA synthetase YP_002343001.1 1637093 D 122587 CDS YP_002343002.1 218768490 908097 1639365..1640783 1 NC_003116.1 NMA1708, unknown, len: 472aa; N-terminal region highly similar to one previously partially sequenced ie. TR:AAD24875 (EMBL:AF073777) hypothetical protein from Neisseria meningitidis (235 aa) fasta scores; E(): 0,90.8% identity in 196 aa overlap.; hypothetical protein 1640783 908097 NMA1708 Neisseria meningitidis Z2491 hypothetical protein YP_002343002.1 1639365 D 122587 CDS YP_002343003.1 218768491 908098 complement(1641720..1642466) 1 NC_003116.1 NMA1709, binding-protein-dependent transport systems inner membrane protein, len: 248aa; similar to many eg. SW:P41074 (GLTJ_ECOLI) glutamate/aspartate transport system permease from Escherichia coli (246 aa) fasta scores; E(): 0, 31.2% identity in 231 aa overlap. Contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component and Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains membrane-spanning hydrophobic regions; binding-protein-dependent transport systems inner membrane protein 1642466 908098 NMA1709 Neisseria meningitidis Z2491 binding-protein-dependent transport systems inner membrane protein YP_002343003.1 1641720 R 122587 CDS YP_002343004.1 218768492 908099 complement(1642645..1643346) 1 NC_003116.1 NMA1710, nuclease, len: 233aa; similar to SW:P29769 (NUC_SHIFL) micrococcal nuclease from Shigella flexneri (174 aa) fasta scores; E(): 7e-08, 35.8% identity in 151 aa overlap. Contains Pfam match to entry PF00565 SNase, Staphylococcal nuclease homologues and Prosite match to PS01123 Thermonuclease family signature 1.; nuclease 1643346 908099 NMA1710 Neisseria meningitidis Z2491 nuclease YP_002343004.1 1642645 R 122587 CDS YP_002343005.1 218768493 908100 complement(1643385..1644056) 1 NC_003116.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 1644056 rpiA 908100 rpiA Neisseria meningitidis Z2491 ribose-5-phosphate isomerase A YP_002343005.1 1643385 R 122587 CDS YP_002343006.1 218768494 908101 complement(1644133..1644615) 1 NC_003116.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1644615 ispF 908101 ispF Neisseria meningitidis Z2491 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_002343006.1 1644133 R 122587 CDS YP_002343007.1 218768495 908102 complement(1644647..1645336) 1 NC_003116.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1645336 ispD 908102 ispD Neisseria meningitidis Z2491 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002343007.1 1644647 R 122587 CDS YP_002343008.1 218768496 908103 complement(1645333..1646067) 1 NC_003116.1 NMA1714, dnaQ, DNA polymerase III, epsilon chain,len: 244aa; similar to many eg. SW:P03007 (DP3E_ECOLI) dnaQ, DNA polymerase III, epsilon chain from Escherichia coli (243 aa) fasta scores; E(): 0, 45.5% identity in 242 aa overlap. Contains Pfam match to entry PF00929 Exonuclease, Exonuclease.; DNA polymerase III subunit epsilon 1646067 908103 NMA1714 Neisseria meningitidis Z2491 DNA polymerase III subunit epsilon YP_002343008.1 1645333 R 122587 CDS YP_002343009.1 218768497 908104 complement(1646223..1647533) 1 NC_003116.1 NMA1715, integral membrane protein, len: 436aa; weakly similar to many of undefined function eg. TR:O84647 (EMBL:AE001334) proposed efflux protein from Chlamydia trachomatis (559 aa) fasta scores; E(): 1.7e-16,25.1% identity in 442 aa overlap. Contains membrane-spanning hydrophobic regions.; integral membrane protein 1647533 908104 NMA1715 Neisseria meningitidis Z2491 integral membrane protein YP_002343009.1 1646223 R 122587 CDS YP_002343010.1 218768498 908105 complement(1647523..1647711) 1 NC_003116.1 NMA1716, inner membrane protein, len: 62aa; contains a non-cleavable N-terminal signal sequence.; inner membrane protein 1647711 908105 NMA1716 Neisseria meningitidis Z2491 inner membrane protein YP_002343010.1 1647523 R 122587 CDS YP_002343011.1 218768499 908106 complement(1647708..1648007) 1 NC_003116.1 NMA1717, unknown, len: 99aa; hypothetical protein 1648007 908106 NMA1717 Neisseria meningitidis Z2491 hypothetical protein YP_002343011.1 1647708 R 122587 CDS YP_002343012.1 218768500 908107 1648328..1649554 1 NC_003116.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1649554 ackA1 908107 ackA1 Neisseria meningitidis Z2491 acetate kinase YP_002343012.1 1648328 D 122587 CDS YP_002343013.1 218768501 908108 complement(1650068..1651909) 1 NC_003116.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 1651909 dipZ 908108 dipZ Neisseria meningitidis Z2491 thiol:disulfide interchange protein YP_002343013.1 1650068 R 122587 CDS YP_002343014.1 218768502 908109 1652000..1652470 1 NC_003116.1 NMA1720, unknown, len: 156aa; hypothetical protein 1652470 908109 NMA1720 Neisseria meningitidis Z2491 hypothetical protein YP_002343014.1 1652000 D 122587 CDS YP_002343015.1 218768503 908110 complement(1652541..1653371) 1 NC_003116.1 NMA1721, transferase, len: 276aa; similar to a region from many phytoene synthases eg. SW:P37272 (PSY_CAPAN) phytoene synthase from Capsicum annuum (Bell pepper) (419 aa) fasta scores; E(): 3e-17, 31.1% identity in 273 aa overlap. Also similar to hypothetical proteins eg. TR:O06001 (EMBL:X86552) hypothetical protein from Bradyrhizobium japonicum (294 aa) fasta scores; E(): 6.6e-23, 35.8% identity in 257 aa overlap. Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases.; transferase 1653371 908110 NMA1721 Neisseria meningitidis Z2491 transferase YP_002343015.1 1652541 R 122587 CDS YP_002343016.1 218768504 908111 complement(1653440..1653922) 1 NC_003116.1 NMA1722, cis-trans isomerase, len: 160aa; similar to many eg. SW:P30856 (SLYD_ECOLI) SlyD,peptidyl-prolyl cis-trans isomerase from Escherichia coli (196 aa) fasta scores; E(): 8.8e-19, 42.3% identity in 163 aa overlap.; peptidyl-prolyl isomerase 1653922 908111 NMA1722 Neisseria meningitidis Z2491 peptidyl-prolyl isomerase YP_002343016.1 1653440 R 122587 CDS YP_002343017.1 218768505 908112 1654411..1654743 1 NC_003116.1 NMA1723, proline-rich repeat protein, len: 110aa; contains 7x K(LH)(PL)(LP)LK(HL)(LP)(PL)P repeat at 20-89aa.; hypothetical protein 1654743 908112 NMA1723 Neisseria meningitidis Z2491 hypothetical protein YP_002343017.1 1654411 D 122587 CDS YP_002343018.1 218768506 908113 1654801..1656168 1 NC_003116.1 NMA1724, hypothetical protein, len: 455aa; C-terminal strongly similar to TR:Q51113 (EMBL:U23782) hypothetical protein (FRAGMENT) from Neisseria meningitidis (195 aa) fasta scores; E(): 0, 85.1% identity in 195 aa overlap. N-terminal region contains Pfam match to entry PF01565 FAD_binding_4.; hypothetical protein 1656168 908113 NMA1724 Neisseria meningitidis Z2491 hypothetical protein YP_002343018.1 1654801 D 122587 CDS YP_002343019.1 218768507 908114 complement(1656349..1658277) 1 NC_003116.1 NMA1725, virulence associated protein,len: 642aa; strongly similar to TR:Q51112 (EMBL:U23782) from Neisseria meningitidis, designated as similar to Shigella flexneri VirG protein (682 aa) fasta scores; E(): 0, 81.7% identity in 650 aa overlap.; virulence associated protein 1658277 908114 NMA1725 Neisseria meningitidis Z2491 virulence associated protein YP_002343019.1 1656349 R 122587 CDS YP_002343020.1 218768508 908115 complement(1658738..1659190) 1 NC_003116.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1659190 smpB 908115 smpB Neisseria meningitidis Z2491 SsrA-binding protein YP_002343020.1 1658738 R 122587 CDS YP_002343021.1 218768509 908116 complement(1659239..1660249) 1 NC_003116.1 NMA1727, rfaF, ADP-heptose:LPS heptosyltransferase II, len: 455aa; similar to many eg. TR:Q51063 (EMBL:Z37141) rfaF, ADP-heptose:LPS heptosyltransferase II from Neisseria gonorrhoeae (336 aa) fasta scores; E(): 0,96.4% identity in 336 aa overlap. Contains Pfam match to entry PF01075 Heptosyltranf, Heptosyltransferase.; ADP-heptose--LPS heptosyltransferase 1660249 908116 NMA1727 Neisseria meningitidis Z2491 ADP-heptose--LPS heptosyltransferase YP_002343021.1 1659239 R 122587 CDS YP_002343022.1 218768510 908117 complement(1660646..1661515) 1 NC_003116.1 NMA1728, methylated-DNA-protein-cysteine methyltransferase, len: 289aa; C-terminal region similar to the methylated-DNA-protein-cysteine methyltransferase domain of many eg. SW:P19220 (ADAB_BACSU) methylated-DNA-protein-cysteine methyltransferase from Bacillus subtilis (179 aa) fasta scores; E(): 1.2e-20,44.0% identity in 141 aa overlap. C-terminal region contains Pfam match to entry PF01035 Methyltransf_1,6-O-methylguanine DNA methyltransferase and Prosite match to PS00374 Methylated-DNA--protein-cysteine methyltransferase active site.; methylated-DNA--protein-cysteine methyltransferase 1661515 908117 NMA1728 Neisseria meningitidis Z2491 methylated-DNA--protein-cysteine methyltransferase YP_002343022.1 1660646 R 122587 CDS YP_002343023.1 218768511 908118 1661673..1662233 1 NC_003116.1 NMA1729, outer membrane protein, len: 186aa; similar to many hypothetical proteins especially in the N-terminal region eg. SW:P77368 (YBCL_ECOLI) hypothetical protein from Escherichia coli (183 aa) fasta scores; E(): 2.5e-13, 46.0% identity in 113 aa overlap.; hypothetical outer membrane protein 1662233 908118 NMA1729 Neisseria meningitidis Z2491 hypothetical outer membrane protein YP_002343023.1 1661673 D 122587 CDS YP_002343024.1 218768512 908119 complement(1663067..1664212) 1 NC_003116.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 1664212 dapE 908119 dapE Neisseria meningitidis Z2491 succinyl-diaminopimelate desuccinylase YP_002343024.1 1663067 R 122587 CDS YP_002343025.1 218768513 908120 complement(1664326..1664946) 1 NC_003116.1 NMA1731, conserved hypothetical protein, len: 206aa; similar to SW:P44013 (Y552_HAEIN) hypothetical protein from Haemophilus influenzae (207 aa) fasta scores; E(): 0, 59.6% identity in 203 aa overlap.; hypothetical protein 1664946 908120 NMA1731 Neisseria meningitidis Z2491 hypothetical protein YP_002343025.1 1664326 R 122587 CDS YP_002343026.1 218768514 908121 complement(1664980..1665489) 1 NC_003116.1 NMA1732, conserved hypothetical protein, len: 169aa; similar to SW:P43971 (Y243_HAEIN) hypothetical protein from Haemophilus influenzae (172 aa) fasta scores; E(): 0, 49.7% identity in 169 aa overlap.; hypothetical protein 1665489 908121 NMA1732 Neisseria meningitidis Z2491 hypothetical protein YP_002343026.1 1664980 R 122587 CDS YP_002343027.1 218768515 908122 complement(1665584..1666135) 1 NC_003116.1 NMA1733, H.8 outer membrane protein, len: 183aa; strongly similar to SW:P07212 (H8_NEIME) H.8 outer membrane protein from Neisseria meningitidis (183 aa) fasta scores; E(): 0, 96.7% identity in 183 aa overlap. Contains Pfam match to entry PF00127 copper-bind, Copper binding proteins, plastocyanin/azurin family and Prosite match to PS00196 Type-1 copper (blue) proteins signature.; outer membrane protein 1666135 908122 NMA1733 Neisseria meningitidis Z2491 outer membrane protein YP_002343027.1 1665584 R 122587 CDS YP_002343028.1 218768516 908124 1666969..1669719 1 NC_003116.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1669719 secA 908124 secA Neisseria meningitidis Z2491 preprotein translocase subunit SecA YP_002343028.1 1666969 D 122587 CDS YP_002343029.1 218768517 908125 1669864..1671636 1 NC_003116.1 synthesizes RNA primers at the replication forks; DNA primase 1671636 dnaG 908125 dnaG Neisseria meningitidis Z2491 DNA primase YP_002343029.1 1669864 D 122587 CDS YP_002343030.1 218768518 908126 1671823..1673751 1 NC_003116.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 1673751 rpoD 908126 rpoD Neisseria meningitidis Z2491 RNA polymerase sigma factor RpoD YP_002343030.1 1671823 D 122587 CDS YP_002343031.1 218768519 908127 1673919..1674770 1 NC_003116.1 NMA1738, insertion element IS1106 transposase, len: 283aa; similar to other copies eg. SW:Q00840 (TRA6_NEIME) transposase for insertion element IS1106 from Neisseria meningitidis (288 aa) fasta scores; E(): 0, 74.3% identity in 230 aa overlap.; insertion element IS1106 transposase 1674770 908127 NMA1738 Neisseria meningitidis Z2491 insertion element IS1106 transposase YP_002343031.1 1673919 D 122587 CDS YP_002343032.1 218768520 908128 complement(1676324..1679158) 1 NC_003116.1 NMA1739, lbpA, lactoferrin binding protein A, len: 944aa; similar to many eg. TR:Q51187 (EMBL:X79838) lbpA,lactoferrin binding protein A from Neisseria meningitidis (940 aa) fasta scores; E(): 0, 95.4% identity in 944 aa overlap. Contains Pfam match to entry PF00593 TonB_boxC,TonB dependent receptor C-terminal region and Prosite match to PS01156 TonB-dependent receptor proteins signature 2.; lactoferrin binding protein A 1679158 908128 NMA1739 Neisseria meningitidis Z2491 lactoferrin binding protein A YP_002343032.1 1676324 R 122587 CDS YP_002343033.1 218768521 908129 complement(1679155..1681380) 1 NC_003116.1 NMA1740, lbpB, lactoferrin-binding protein, len: 741aa; similar to many eg. TR:AAD31768 (EMBL:AF123380) lbpB, lactoferrin-binding protein from Neisseria meningitidis (741 aa) fasta scores; E(): 0, 83.4% identity in 749 aa overlap. Contains Pfam match to entry PF01298 Lipoprotein_5, Transferrin binding protein and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains potential coiled-coil region around 460aa.; lactoferrin-binding protein 1681380 908129 NMA1740 Neisseria meningitidis Z2491 lactoferrin-binding protein YP_002343033.1 1679155 R 122587 CDS YP_002343034.1 218768522 908131 complement(1684464..1686098) 1 NC_003116.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1686098 pyrG 908131 pyrG Neisseria meningitidis Z2491 CTP synthetase YP_002343034.1 1684464 R 122587 CDS YP_002343035.1 218768523 908132 complement(1686210..1687880) 1 NC_003116.1 NMA1743, fadD, long-chain-fatty-acid--CoA-ligase,len: 556aa; similar to many eg. SW:P29212 (LCFA_ECOLI) fadD, long-chain-fatty-acid--CoA-ligase from Escherichia coli (561 aa) fasta scores; E(): 0, 56.6% identity in 557 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Prosite match to PS00455 AMP-binding domain signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; long-chain-fatty-acid--CoA-ligase 1687880 908132 NMA1743 Neisseria meningitidis Z2491 long-chain-fatty-acid--CoA-ligase YP_002343035.1 1686210 R 122587 CDS YP_002343036.1 218768524 908133 complement(1687951..1689102) 1 NC_003116.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1689102 mnmA 908133 mnmA Neisseria meningitidis Z2491 tRNA-specific 2-thiouridylase MnmA YP_002343036.1 1687951 R 122587 CDS YP_002343037.1 218768525 908138 complement(1689179..1689652) 1 NC_003116.1 NMA1745, unknown, len: 157 aa; similar to hypothetical proteins e.g. TR:O67294 (EMBL:AE000731) Aquifex aeolicus AQ_1253 (151 aa), fasta scores; E(): 1.1e-09, 33.1% identity in 151 aa overlap; hypothetical protein 1689652 908138 NMA1745 Neisseria meningitidis Z2491 hypothetical protein YP_002343037.1 1689179 R 122587 CDS YP_002343038.1 218768526 906026 complement(1689789..1690172) 1 NC_003116.1 NMA1746, dgk, diacylglycerol kinase, len: 127aa; similar to many eg. SW:P00556 (KDGL_ECOLI) dgk,diacylglycerol kinase from Escherichia coli (121 aa) fasta scores; E(): 3.6e-12, 43.5% identity in 108 aa overlap. Contains Pfam match to entry PF01219 DAGK_prokar,Prokaryotic diacylglycerol kinase. Also contains membrane-spanning hydrophobic regions.; diacylglycerol kinase 1690172 906026 NMA1746 Neisseria meningitidis Z2491 diacylglycerol kinase YP_002343038.1 1689789 R 122587 CDS YP_002343039.1 218768527 907674 complement(1690484..1691440) 1 NC_003116.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 1691440 gshB 907674 gshB Neisseria meningitidis Z2491 glutathione synthetase YP_002343039.1 1690484 R 122587 CDS YP_002343040.1 218768528 907673 complement(1691533..1693254) 1 NC_003116.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 1693254 glnS 907673 glnS Neisseria meningitidis Z2491 glutaminyl-tRNA synthetase YP_002343040.1 1691533 R 122587 CDS YP_002343041.1 218768529 907672 complement(1693333..1694106) 1 NC_003116.1 NMA1749, glpR, glycerol 3-phosphate regulon repressor, len: 257aa; similar to many eg. SW:P09392 (GLPR_ECOLI) glpR, glycerol 3-phosphate regulon repressor (252 aa) fasta scores; E(): 0, 43.9% identity in 253 aa overlap. Contains Pfam match to entry PF00455 deoR,Bacterial regulatory proteins, deoR family and Prosite match to PS00894 Bacterial regulatory proteins, deoR family signature. Also contains helix-turn-helix 22-43aa (+4.67 SD).; glycerol 3-phosphate regulon repressor 1694106 907672 NMA1749 Neisseria meningitidis Z2491 glycerol 3-phosphate regulon repressor YP_002343041.1 1693333 R 122587 CDS YP_002343042.1 218768530 907671 complement(1694149..1695051) 1 NC_003116.1 NMA1750, hypothetical integral membrane protein,len: 300aa; similar to many hypothetical proteins eg. TR:BAA35588 (EMBL:D90724) hypothetical protein from Escherichia coli (299 aa) fasta scores; E(): 0, 39.0% identity in 300 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1695051 907671 NMA1750 Neisseria meningitidis Z2491 hypothetical protein YP_002343042.1 1694149 R 122587 CDS YP_002343043.1 218768531 907670 complement(1695200..1695916) 1 NC_003116.1 NMA1751, gntR-family transcriptional regulator, len: 238aa; similar to many proposed transcriptional regulators eg. TR:CAB46933 (EMBL:AL096822) gntR-family transcriptional regulator from Streptomyces coelicolor (216 aa) fasta scores; E(): 5.8e-13, 32.7% identity in 199 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and helix-turn-helix 50-71aa (+3.34 SD).; gntR-family transcriptional regulator 1695916 907670 NMA1751 Neisseria meningitidis Z2491 gntR-family transcriptional regulator YP_002343043.1 1695200 R 122587 CDS YP_002343044.1 218768532 908137 complement(1696485..1696835) 1 NC_003116.1 NMA1753, unknown, len: 116aa; similar to many of undefined function eg. SW:P24246 (YHFA_ECOLI) hypothetical protein from Escherichia coli (134 aa) fasta scores; E(): 1e-23, 51.8% identity in 114 aa overlap.; hypothetical protein 1696835 908137 NMA1753 Neisseria meningitidis Z2491 hypothetical protein YP_002343044.1 1696485 R 122587 CDS YP_002343045.1 218768533 907563 complement(1697025..1697696) 1 NC_003116.1 NMA1754, unknown, len: 223aa; hypothetical protein 1697696 907563 NMA1754 Neisseria meningitidis Z2491 hypothetical protein YP_002343045.1 1697025 R 122587 CDS YP_002343046.1 218768534 907669 complement(1697712..1698338) 1 NC_003116.1 NMA1755, purN, phosphoribosylglycinamide transformylase, len: 208aa; similar to many eg. SW:P08179 (PUR3_ECOLI) purN, phosphoribosylglycinamide transformylase from Escherichia coli (212 aa) fasta scores; E(): 0, 51.8% identity in 193 aa overlap. Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase.; phosphoribosylglycinamide transformylase 1698338 907669 NMA1755 Neisseria meningitidis Z2491 phosphoribosylglycinamide transformylase YP_002343046.1 1697712 R 122587 CDS YP_002343047.1 218768535 907668 complement(1698445..1699263) 1 NC_003116.1 NMA1756, peptidyl-prolyl isomerase, len: 272aa; similar to many eg. TR:O08437 (EMBL:U56832) peptidyl-prolyl isomerase from Aeromonas hydrophila (268 aa) fasta scores; E(): 5.4e-30, 44.5% identity in 265 aa overlap. Contains Pfam match to entry PF00254 FKBP,FKBP-type peptidyl-prolyl cis-trans isomerases; Pfam match to entry PF01346 FKBP_N, Domain amino terminal to FKBP-type peptidyl-prolyl isomerase and Prosite match to PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.; peptidyl-prolyl isomerase 1699263 907668 NMA1756 Neisseria meningitidis Z2491 peptidyl-prolyl isomerase YP_002343047.1 1698445 R 122587 CDS YP_002343048.1 218768536 907667 complement(1699522..1699962) 1 NC_003116.1 NMA1757, holC, DNA polymerase III chi subunit, len: 146aa; similar to SW:P28905 (HOLC_ECOLI) holC, DNA polymerase III chi subunit from Escherichia coli (147 aa) fasta scores; E(): 8.9e-05, 29.9% identity in 147 aa overlap.; DNA polymerase III subunit chi 1699962 907667 NMA1757 Neisseria meningitidis Z2491 DNA polymerase III subunit chi YP_002343048.1 1699522 R 122587 CDS YP_002343049.1 218768537 907666 complement(1700025..1701431) 1 NC_003116.1 NMA1758, pepA, aminopeptidase A, len: 468aa; similar to many aminopeptidases eg. SW:P11648 (AMPA_ECOLI) pepA, aminopeptidase A from Escherichia coli (503 aa) fasta scores; E(): 0, 50.3% identity in 362 aa overlap. Contains Pfam match to entry PF00883 Peptidase_M17,Cytosol aminopeptidase family and Prosite match to PS00631 Cytosol aminopeptidase signature.; aminopeptidase 1701431 907666 NMA1758 Neisseria meningitidis Z2491 aminopeptidase YP_002343049.1 1700025 R 122587 CDS YP_002343050.1 218768538 907665 1701601..1702716 1 NC_003116.1 NMA1759, conserved hypothetical integral membrane protein, len: 371aa; similar to SW:P39340 (YJGP_ECOLI) hypothetical protein from Escherichia coli (366 aa) fasta scores; E(): 2.1e-26, 29.2% identity in 360 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1702716 907665 NMA1759 Neisseria meningitidis Z2491 hypothetical protein YP_002343050.1 1701601 D 122587 CDS YP_002343051.1 218768539 907664 1702713..1703783 1 NC_003116.1 NMA1760, conserved hypothetical integral membrane protein, len: 356aa; similar to many eg. SW:P39341 (YJGQ_ECOLI) hypothetical protein from Escherichia coli (361 aa) fasta scores; E(): 1.1e-32, 28.8% identity in 354 aa overlap. Contains membrane-spanning hydrophobic regions; hypothetical protein 1703783 907664 NMA1760 Neisseria meningitidis Z2491 hypothetical protein YP_002343051.1 1702713 D 122587 CDS YP_002343052.1 218768540 907663 1704093..1706678 1 NC_003116.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 1706678 acnB 907663 acnB Neisseria meningitidis Z2491 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_002343052.1 1704093 D 122587 CDS YP_002343053.1 218768541 907662 1706820..1707815 1 NC_003116.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 1707815 argF 907662 argF Neisseria meningitidis Z2491 ornithine carbamoyltransferase YP_002343053.1 1706820 D 122587 CDS YP_002343054.1 218768542 907661 complement(1708039..1709052) 1 NC_003116.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 1709052 ilvC 907661 ilvC Neisseria meningitidis Z2491 ketol-acid reductoisomerase YP_002343054.1 1708039 R 122587 CDS YP_002343055.1 218768543 907660 complement(1709132..1709425) 1 NC_003116.1 NMA1764, conserved hypothetical protein, len: 97aa; similar to many eg. SW:P94425 (YCNE_BACSU) hypothetical protein from Bacillus subtilis (95 aa) fasta scores; E(): 4.5e-12, 48.6% identity in 74 aa overlap.; hypothetical protein 1709425 907660 NMA1764 Neisseria meningitidis Z2491 hypothetical protein YP_002343055.1 1709132 R 122587 CDS YP_002343056.1 218768544 907659 complement(1709492..1709983) 1 NC_003116.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 1709983 ilvH 907659 ilvH Neisseria meningitidis Z2491 acetolactate synthase 3 regulatory subunit YP_002343056.1 1709492 R 122587 CDS YP_002343057.1 218768545 907658 complement(1709994..1711721) 1 NC_003116.1 NMA1766, ilvI, acetolactate synthase isozyme III large subunit, len: 575aa; similar to many eg. SW:P00893 (ILVI_ECOLI) ilvI, acetolactate synthase isozyme III large subunit from Escherichia coli (574 aa) fasta scores; E(): 0, 57.5% identity in 572 aa overlap. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes and Prosite match to PS00187 Thiamine pyrophosphate enzymes signature.; acetolactate synthase isozyme III large subunit 1711721 907658 NMA1766 Neisseria meningitidis Z2491 acetolactate synthase isozyme III large subunit YP_002343057.1 1709994 R 122587 CDS YP_002343058.1 218768546 907657 1712842..1713495 1 NC_003116.1 NMA1767, lipoprotein, len: 217aa; contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some similarity to several hypothetical proteins eg. TR:Q9ZCW7 (EMBL:AJ235272) hypothetical protein from Rickettsia prowazekii (205 aa) fasta scores; E(): 1.7e-19, 43.9% identity in 139 aa overlap.; lipoprotein 1713495 907657 NMA1767 Neisseria meningitidis Z2491 lipoprotein YP_002343058.1 1712842 D 122587 CDS YP_002343059.1 218768547 907656 1713574..1714227 1 NC_003116.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ; ATP phosphoribosyltransferase 1714227 hisG 907656 hisG Neisseria meningitidis Z2491 ATP phosphoribosyltransferase YP_002343059.1 1713574 D 122587 CDS YP_002343060.1 218768548 907655 1714331..1715230 1 NC_003116.1 NMA1769, unknown, len: 229aa; hypothetical protein 1715230 907655 NMA1769 Neisseria meningitidis Z2491 hypothetical protein YP_002343060.1 1714331 D 122587 CDS YP_002343061.1 218768549 907654 1715227..1716516 1 NC_003116.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1716516 hisD 907654 hisD Neisseria meningitidis Z2491 histidinol dehydrogenase YP_002343061.1 1715227 D 122587 CDS YP_002343062.1 218768550 907653 1716562..1717659 1 NC_003116.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1717659 hisC 907653 hisC Neisseria meningitidis Z2491 histidinol-phosphate aminotransferase YP_002343062.1 1716562 D 122587 CDS YP_002343063.1 218768551 907652 1717839..1718573 1 NC_003116.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1718573 hisB 907652 hisB Neisseria meningitidis Z2491 imidazoleglycerol-phosphate dehydratase YP_002343063.1 1717839 D 122587 CDS YP_002343064.1 218768552 907651 1718668..1719537 1 NC_003116.1 NMA1773, unknown, len: 289aa; similar to many of undefined function eg. TR:Q9ZLJ4 (EMBL:AE001491) dehydrogenase from Helicobacter pylori (285 aa) fasta scores; E(): 0, 44.2% identity in 285 aa overlap.; hypothetical protein 1719537 907651 NMA1773 Neisseria meningitidis Z2491 hypothetical protein YP_002343064.1 1718668 D 122587 CDS YP_002343065.1 218768553 907650 1719815..1720177 1 NC_003116.1 NMA1774, transcriptional regulator, len: 120aa; similar to many of undefined function eg. SW:P42193 (PAPX_ECOLI) Papx protein from Escherichia coli (164 aa) fasta scores; E(): 0.024, 27.6% identity in 116 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family and helix-turn-helix motif 45-66aa (+3.67 SD).; transcriptional regulator 1720177 907650 NMA1774 Neisseria meningitidis Z2491 transcriptional regulator YP_002343065.1 1719815 D 122587 CDS YP_002343066.1 218768554 907649 join(1720208..1720540,1720540..1721214) 1 NC_003116.1 insertion element IS1106A3 transposase 1721214 907649 NMA1775 Neisseria meningitidis Z2491 insertion element IS1106A3 transposase YP_002343066.1 1720208 D 122587 CDS YP_002343067.1 218768555 907647 1721483..1722346 1 NC_003116.1 NMA1777, integral membrane protein, len: 287aa; contains membrane-spanning hydrophobic regions.; integral membrane protein 1722346 907647 NMA1777 Neisseria meningitidis Z2491 integral membrane protein YP_002343067.1 1721483 D 122587 CDS YP_002343068.1 218768556 907646 complement(1722397..1723449) 1 NC_003116.1 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1723449 907646 NMA1778 Neisseria meningitidis Z2491 periplasmic protease YP_002343068.1 1722397 R 122587 CDS YP_002343069.1 218768557 907645 complement(1724296..1724859) 1 NC_003116.1 NMA1779, pgsA,CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, len: 187aa; similar to many eg. SW:P06978 (PGSA_ECOLI) pgsA,CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Escherichia coli (181 aa) fasta scores; E(): 2.3e-31, 51.1% identity in 182 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase and Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature.; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1724859 907645 NMA1779 Neisseria meningitidis Z2491 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_002343069.1 1724296 R 122587 CDS YP_002343070.1 218768558 907643 complement(1725086..1725388) 1 NC_003116.1 NMA1781, doubtful CDS, function unknown, len: 100aa; hypothetical protein 1725388 907643 NMA1781 Neisseria meningitidis Z2491 hypothetical protein YP_002343070.1 1725086 R 122587 CDS YP_002343071.1 218768559 907642 complement(1725670..1726005) 1 NC_003116.1 NMA1782, conserved hypothetical protein, len: 111aa; similar to many eg. SW:Q57498 (YA53_HAEIN) hypothetical protein from Haemophilus influenzae (113 aa) fasta scores; E(): 6.3e-29, 75.9% identity in 112 aa overlap.; hypothetical protein 1726005 907642 NMA1782 Neisseria meningitidis Z2491 hypothetical protein YP_002343071.1 1725670 R 122587 CDS YP_002343072.1 218768560 907641 1726134..1727039 1 NC_003116.1 NMA1783, AraC-family transcriptional regulator,len: 301aa; similar to many eg. TR:AAD44693 (EMBL:AF128627) MtrA AraC-like protein from Neisseria gonorrhoeae (301 aa) fasta scores; E(): 0, 94.0% identity in 301 aa overlap. Contains Pfam match to entry PF00165 HTH_2, Bacterial regulatory helix-turn-helix proteins,araC family.; AraC family transcriptional regulator 1727039 907641 NMA1783 Neisseria meningitidis Z2491 AraC family transcriptional regulator YP_002343072.1 1726134 D 122587 CDS YP_002343073.1 218768561 907640 complement(1727101..1727676) 1 NC_003116.1 NMA1784, unknown, len: 191aa; hypothetical protein 1727676 907640 NMA1784 Neisseria meningitidis Z2491 hypothetical protein YP_002343073.1 1727101 R 122587 CDS YP_002343074.1 218768562 907639 1727736..1728638 1 NC_003116.1 NMA1785, conserved hypothetical integral membrane protein, transport function, len: 300aa; similar to many eg. TR:O83951 (EMBL:AE001266) conserved hypothetical integral membrane protein from Treponema pallidum (294 aa) fasta scores; E(): 2.4e-15, 31.4% identity in 271 aa overlap. Contains Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains membrane-spanning hydrophobic regions.; hypothetical protein 1728638 907639 NMA1785 Neisseria meningitidis Z2491 hypothetical protein YP_002343074.1 1727736 D 122587 CDS YP_002343075.1 218768563 907638 complement(1728679..1729809) 1 NC_003116.1 NMA1786, polyamine permease substrate-binding protein, len: 376aa; similar to many eg. SW:P31133 (POTF_ECOLI) putrescine-binding periplasmic protein (370 aa) fasta scores; E(): 0, 43.2% identity in 347 aa overlap. Also similar to NMA0831 (fasta scores; E(): 0, 60.8% identity in 380 aa overlap) and NMA2023 fasta scores; (E(): 0, 55.2% identity in 377 aa overlap) from Neisseria meningitidis. Contains a cleavable N-terminal signal sequence.; polyamine permease substrate-binding protein 1729809 907638 NMA1786 Neisseria meningitidis Z2491 polyamine permease substrate-binding protein YP_002343075.1 1728679 R 122587 CDS YP_002343076.1 218768564 907637 1730014..1732638 1 NC_003116.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1732638 alaS 907637 alaS Neisseria meningitidis Z2491 alanyl-tRNA synthetase YP_002343076.1 1730014 D 122587 CDS YP_002343077.1 218768565 907636 1732700..1733431 1 NC_003116.1 NMA1789, unknown, len: 243aa; lies in a DNA region of unusually low GC content.; hypothetical protein 1733431 907636 NMA1789 Neisseria meningitidis Z2491 hypothetical protein YP_002343077.1 1732700 D 122587 CDS YP_002343078.1 218768566 907635 1734140..1736551 1 NC_003116.1 NMA1791, unknown, len: 803aa; similar to but approx. 110aa shorter than TR:O30579 (EMBL:AF012532) hypothetical protein from Bacillus subtilis (879 aa) fasta scores; E(): 0, 38.5% identity in 816 aa overlap.; hypothetical protein 1736551 907635 NMA1791 Neisseria meningitidis Z2491 hypothetical protein YP_002343078.1 1734140 D 122587 CDS YP_002343079.1 218768567 907634 1737566..1738834 1 NC_003116.1 NMA1792, unknown, len: 422aa; lies in a DNA region of unusually low GC content.; hypothetical protein 1738834 907634 NMA1792 Neisseria meningitidis Z2491 hypothetical protein YP_002343079.1 1737566 D 122587 CDS YP_002343080.1 218768568 907633 1738846..1739157 1 NC_003116.1 NMA1793, unknown, len: 103aa; lies in a DNA region of unusually low GC content.; hypothetical protein 1739157 907633 NMA1793 Neisseria meningitidis Z2491 hypothetical protein YP_002343080.1 1738846 D 122587 CDS YP_002343081.1 218768569 907632 1739161..1739361 1 NC_003116.1 NMA1794, unknown, len: 66aa; lies in a DNA region of unusually low GC content.; hypothetical protein 1739361 907632 NMA1794 Neisseria meningitidis Z2491 hypothetical protein YP_002343081.1 1739161 D 122587 CDS YP_002343082.1 218768570 907631 1739599..1739829 1 NC_003116.1 NMA1795, unknown, len: 76aa; lies in a DNA region of unusually low GC content and contains membrane-spanning hydrophobic regions.; hypothetical protein 1739829 907631 NMA1795 Neisseria meningitidis Z2491 hypothetical protein YP_002343082.1 1739599 D 122587 CDS YP_002343083.1 218768571 907630 1739857..1740159 1 NC_003116.1 NMA1796, unknown, len: 100aa; lies in a DNA region of unusually low GC content.; hypothetical protein 1740159 907630 NMA1796 Neisseria meningitidis Z2491 hypothetical protein YP_002343083.1 1739857 D 122587 CDS YP_002343084.1 218768572 907629 1740491..1742110 1 NC_003116.1 NMA1797, tspB, TspB protein, len: 539aa; strongly similar to TR:O87783 (EMBL:AJ010115) a potent T-cell and B-cell stimulating Neisseria-specific antigen from Neisseria meningitidis (504 aa) fasta scores; E(): 0,85.6% identity in 465 aa overlap.; TspB protein 1742110 907629 NMA1797 Neisseria meningitidis Z2491 TspB protein YP_002343084.1 1740491 D 122587 CDS YP_002343085.1 218768573 907628 1742413..1742697 1 NC_003116.1 NMA1798, integral membrane protein, len: 94aa; contains a non-cleavable N-terminal signal sequence and membrane-spanning hydrophobic region.; integral membrane protein 1742697 907628 NMA1798 Neisseria meningitidis Z2491 integral membrane protein YP_002343085.1 1742413 D 122587 CDS YP_002343086.1 218768574 907627 1742698..1743885 1 NC_003116.1 NMA1799, unknown, len: 395aa; similar to TR:O82966 (EMBL:AB015669) hypothetical protein from Burkholderia solanacearum (364 aa) fasta scores; E(): 1.1e-20; 31.0% identity in 358 aa overlap.; hypothetical protein 1743885 907627 NMA1799 Neisseria meningitidis Z2491 hypothetical protein YP_002343086.1 1742698 D 122587 CDS YP_002343087.1 218768575 907626 1744100..1745056 1 NC_003116.1 NMA1800, invertase/transposase, len: 318aa; similar to other proposed invertases eg. TR:P72078 (EMBL:U65994) pilin gene inverting protein homolog from Neisseria gonorrhoeae (320 aa) fasta scores; E(): 0, 42.6% identity in 317 aa overlap. Contains Pfam match to entry PF01548 Transposase_9.; invertase/transposase 1745056 907626 NMA1800 Neisseria meningitidis Z2491 invertase/transposase YP_002343087.1 1744100 D 122587 CDS YP_002343088.1 218768576 907625 complement(1745395..1746078) 1 NC_003116.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1746078 gpmA 907625 gpmA Neisseria meningitidis Z2491 phosphoglyceromutase YP_002343088.1 1745395 R 122587 CDS YP_002343089.1 218768577 907624 1746380..1748677 1 NC_003116.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 1748677 parC 907624 parC Neisseria meningitidis Z2491 DNA topoisomerase IV subunit A YP_002343089.1 1746380 D 122587 CDS YP_002343090.1 218768578 907623 1748697..1750214 1 NC_003116.1 NMA1803, two component sensor kinase, len: 505aa; similar to many eg. TR:Q51530 (EMBL:L22436) pilin transcripoitnal regulator (530 aa) fasta scores; E(): 4.3e-22; 25.8% identity in 496 aa overlap. Also strongly similar to TR:P72076 (EMBL:U65994) Rsp from Neisseria gonorrhoeae (572 aa) fasta scores; E(): 0, 75.5% identity in 335 aa overlap. Contains membrane-spanning hydrophobic regions in the N-terminal region and Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain in the C-terminal region.; two component sensor kinase 1750214 907623 NMA1803 Neisseria meningitidis Z2491 two component sensor kinase YP_002343090.1 1748697 D 122587 CDS YP_002343091.1 218768579 907622 1750266..1750733 1 NC_003116.1 NMA1805, two component response regulator,len: 155aa; similar to the N-terminus of many regulators eg. SW:Q00934 (PILR_PSEAE) PilR typeIV fimbriae expression regulator from Pseudomonas aeruginosa (446 aa) fasta scores; E(): 3.2e-14, 41.2% identity in 153 aa overlap. Contains Pfam match to entry PF00072 response_reg,Response regulator receiver domain and Pfam match to entry PF00158 sigma54, Sigma-54 transcription factors and helix-turn-helix motif 130-151 (+3.44 SD).; two component response regulator 1750733 907622 NMA1805 Neisseria meningitidis Z2491 two component response regulator YP_002343091.1 1750266 D 122587 CDS YP_002343092.1 218768580 907621 1750837..1751589 1 NC_003116.1 NMA1806, conserved hypothetical protein, len: 250aa; similar to many eg. SW:P72077 (YHIQ_NEIGO) hypothetical protein from Neisseria gonorrhoeae (250 aa) fasta scores; E(): 0, 95.6% identity in 250 aa overlap.; hypothetical protein 1751589 907621 NMA1806 Neisseria meningitidis Z2491 hypothetical protein YP_002343092.1 1750837 D 122587 CDS YP_002343093.1 218768581 907619 complement(1752924..1754093) 1 NC_003116.1 NMA1808, metZ, O-succinylhomoserine sulfhydrolase,len: 389aa; similar to many eg. SW:P55218 (METZ_PSEAE) metZ, O-succinylhomoserine sulfhydrolase from Pseudomonas aeruginosa (403 aa) fasta scores; E(): 0, 49.9% identity in 381 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme.; O-succinylhomoserine sulfhydrolase 1754093 907619 NMA1808 Neisseria meningitidis Z2491 O-succinylhomoserine sulfhydrolase YP_002343093.1 1752924 R 122587 CDS YP_002343094.1 218768582 907618 complement(1754391..1755152) 1 NC_003116.1 NMA1809, unknown, len: 253aa; hypothetical protein 1755152 907618 NMA1809 Neisseria meningitidis Z2491 hypothetical protein YP_002343094.1 1754391 R 122587 CDS YP_002343095.1 218768583 907617 1755252..1755503 1 NC_003116.1 NMA1810, unknown, len: 83aa; hypothetical protein 1755503 907617 NMA1810 Neisseria meningitidis Z2491 hypothetical protein YP_002343095.1 1755252 D 122587 CDS YP_002343096.1 218768584 907616 1755555..1756361 1 NC_003116.1 NMA1811, hisJ, histidine-binding periplasmic protein, len: 268aa; similar to many eg. SW:Q06758 (HISJ_NEIGO) hisJ, histidine-binding periplasmic protein from Neisseria gonorrhoeae (268 aa) fasta scores; E(): 0,96.6% identity in 268 aa overlap. Contains Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.; histidine-binding periplasmic protein 1756361 907616 NMA1811 Neisseria meningitidis Z2491 histidine-binding periplasmic protein YP_002343096.1 1755555 D 122587 CDS YP_002343097.1 218768585 907615 1756551..1758191 1 NC_003116.1 NMA1812, fumA, fumarate hydratase, len: 546aa; similar to many eg. SW:P00923 (FUMA_ECOLI) fumA, fumarate hydratase from Escherichia coli (547 aa) fasta scores; E(): 4.2e-33, 31.8% identity in 541 aa overlap.; fumarate hydratase 1758191 907615 NMA1812 Neisseria meningitidis Z2491 fumarate hydratase YP_002343097.1 1756551 D 122587 CDS YP_002343098.1 218768586 907614 1758289..1759701 1 NC_003116.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 1759701 trkA 907614 trkA Neisseria meningitidis Z2491 potassium transporter peripheral membrane protein YP_002343098.1 1758289 D 122587 CDS YP_002343099.1 218768587 907613 1760005..1760970 1 NC_003116.1 NMA1814, insertion element IS1655 transposase, len: 321aa; similar to many eg. SW:P37247 (TRA4_BACFR) transposase for insertion element IS4351 from Bacteroides fragilis (326 aa) fasta scores; E(): 0, 41.9% identity in 310 aa overlap. Also N-terminal region almost identical to TR:P72086 (EMBL:U56740) transposase homolog (fragment) from Neisseria meningitidis (104 aa) fasta scores; E(): 0,99.0% identity in 104 aa overlap. Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family and helix-turn-helix motif 22-43aa (+4.99 SD).; insertion element IS1655 transposase 1760970 907613 NMA1814 Neisseria meningitidis Z2491 insertion element IS1655 transposase YP_002343099.1 1760005 D 122587 CDS YP_002343100.1 218768588 907612 1762484..1763290 1 NC_003116.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 1763290 thiD 907612 thiD Neisseria meningitidis Z2491 phosphomethylpyrimidine kinase YP_002343100.1 1762484 D 122587 CDS YP_002343101.1 218768589 907611 complement(1763340..1764194) 1 NC_003116.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1764194 907611 NMA1816 Neisseria meningitidis Z2491 tellurite resistance protein TehB YP_002343101.1 1763340 R 122587 CDS YP_002343102.1 218768590 907610 1764323..1764760 1 NC_003116.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 1764760 rnhA 907610 rnhA Neisseria meningitidis Z2491 ribonuclease H YP_002343102.1 1764323 D 122587 CDS YP_002343103.1 218768591 907609 1766062..1766466 1 NC_003116.1 NMA1818, unknown, len: 143aa; hypothetical protein 1766466 907609 NMA1818 Neisseria meningitidis Z2491 hypothetical protein YP_002343103.1 1766062 D 122587 CDS YP_002343104.1 218768592 907608 1766506..1767690 1 NC_003116.1 NMA1819, conserved hypothetical protein, len: 394aa; regions similar to many eg. TR:O87499 (EMBL:AF081283) hypothetical protein from Escherichia coli (304 aa) fasta scores; E(): 0, 40.5% identity in 306 aa overlap.; hypothetical protein 1767690 907608 NMA1819 Neisseria meningitidis Z2491 hypothetical protein YP_002343104.1 1766506 D 122587 CDS YP_002343105.1 218768593 907607 complement(1767753..1768286) 1 NC_003116.1 NMA1820, gpxA, glutathione peroxidase, len: 177aa; previously sequenced and characterised therefore identical to SW:P52036 (GPXA_NEIME) gpxA, glutathione peroxidase from Neisseria meningitidis (177 aa) fasta scores; E(): 0,100.0% identity in 177 aa overlap. Contains Pfam match to entry PF00255 GSHPx, Glutathione peroxidases; Prosite match to PS00763 Glutathione peroxidases signature 2 and Prosite match to PS00460 Glutathione peroxidases selenocysteine active site.; glutathione peroxidase 1768286 907607 NMA1820 Neisseria meningitidis Z2491 glutathione peroxidase YP_002343105.1 1767753 R 122587 CDS YP_002343106.1 218768594 907606 complement(1768546..1769385) 1 NC_003116.1 NMA1821, conserved hypothetical protein, len: 279aa; similar to SW:P44243 (YF23_HAEIN) hypothetical protein from Haemophilus influenzae (296 aa) fasta scores; E(): 0, 47.3% identity in 277 aa overlap.; hypothetical protein 1769385 907606 NMA1821 Neisseria meningitidis Z2491 hypothetical protein YP_002343106.1 1768546 R 122587 CDS YP_002343107.1 218768595 907605 complement(1769733..1770221) 1 NC_003116.1 NMA1822, unknown, len: 162aa; hypothetical protein 1770221 907605 NMA1822 Neisseria meningitidis Z2491 hypothetical protein YP_002343107.1 1769733 R 122587 CDS YP_002343108.1 218768596 907604 complement(1770222..1770845) 1 NC_003116.1 NMA1823, unknown, len: 207aa; hypothetical protein 1770845 907604 NMA1823 Neisseria meningitidis Z2491 hypothetical protein YP_002343108.1 1770222 R 122587 CDS YP_002343109.1 218768597 907603 complement(1770842..1773124) 1 NC_003116.1 NMA1824, unknown, len: 760aa; hypothetical protein 1773124 907603 NMA1824 Neisseria meningitidis Z2491 hypothetical protein YP_002343109.1 1770842 R 122587 CDS YP_002343110.1 218768598 907602 complement(1773127..1773693) 1 NC_003116.1 NMA1825, unknown, len: 188aa; weakly similar to SW:P75982 (YMFQ_ECOLI) hypothetical protein from Escherichia coli (194 aa) fasta scores; E(): 1.1e-06,26.3% identity in 190 aa overlap.; hypothetical protein 1773693 907602 NMA1825 Neisseria meningitidis Z2491 hypothetical protein YP_002343110.1 1773127 R 122587 CDS YP_002343111.1 218768599 907601 complement(1773690..1774265) 1 NC_003116.1 NMA1826, unknown, len: 191aa; hypothetical protein 1774265 907601 NMA1826 Neisseria meningitidis Z2491 hypothetical protein YP_002343111.1 1773690 R 122587 CDS YP_002343112.1 218768600 907600 complement(1774268..1774753) 1 NC_003116.1 NMA1827, unknown, len: 161aa; hypothetical protein 1774753 907600 NMA1827 Neisseria meningitidis Z2491 hypothetical protein YP_002343112.1 1774268 R 122587 CDS YP_002343113.1 218768601 907599 complement(1774750..1775103) 1 NC_003116.1 NMA1828, unknown, len: 117aa; hypothetical protein 1775103 907599 NMA1828 Neisseria meningitidis Z2491 hypothetical protein YP_002343113.1 1774750 R 122587 CDS YP_002343114.1 218768602 907598 complement(1775164..1775793) 1 NC_003116.1 NMA1829, unknown, len: 209aa; note weak similarity to SW:P31340 (VPV_BPP2) baseplate assembly protein V from Bacteriophage P2 (211 aa) fasta scores; E(): 0.0055, 27.1% identity in 214 aa overlap.; hypothetical protein 1775793 907598 NMA1829 Neisseria meningitidis Z2491 hypothetical protein YP_002343114.1 1775164 R 122587 CDS YP_002343115.1 218768603 907595 complement(1775794..1776933) 1 NC_003116.1 NMA1830, unknown, len: 379aa; note weak similarity to SW:P08558 (VPP_BPMU) 43kD tail protein from Bacteriophage Mu (379 aa) fasta scores; E(): 1.9e-11,26.2% identity in 362 aa overlap.; hypothetical protein 1776933 907595 NMA1830 Neisseria meningitidis Z2491 hypothetical protein YP_002343115.1 1775794 R 122587 CDS YP_002343116.1 218768604 907594 complement(1776917..1778284) 1 NC_003116.1 NMA1831, unknown, len: 455aa; weak similarity to SW:P71389 (VPN_HAEIN) cryptic Mu-phage N protein from Haemophilus influenzae (455 aa) fasta scores; E(): 0,23.3% identity in 463 aa overlap.; hypothetical protein 1778284 907594 NMA1831 Neisseria meningitidis Z2491 hypothetical protein YP_002343116.1 1776917 R 122587 CDS YP_002343117.1 218768605 907593 complement(1778284..1778526) 1 NC_003116.1 NMA1832, unknown, len: 80aa; hypothetical protein 1778526 907593 NMA1832 Neisseria meningitidis Z2491 hypothetical protein YP_002343117.1 1778284 R 122587 CDS YP_002343118.1 218768606 907592 complement(1778654..1780333) 1 NC_003116.1 NMA1833, DNA-binding protein , len: 559aa; contains helix-turn-helix motif 84-105aa (+4.43 SD).; hypothetical protein 1780333 907592 NMA1833 Neisseria meningitidis Z2491 hypothetical protein YP_002343118.1 1778654 R 122587 CDS YP_002343119.1 218768607 907591 complement(1780330..1780578) 1 NC_003116.1 NMA1834, unknown, len: 82aa; hypothetical protein 1780578 907591 NMA1834 Neisseria meningitidis Z2491 hypothetical protein YP_002343119.1 1780330 R 122587 CDS YP_002343120.1 218768608 907590 complement(1780536..1780925) 1 NC_003116.1 NMA1835, unknown, len: 129aa; hypothetical protein 1780925 907590 NMA1835 Neisseria meningitidis Z2491 hypothetical protein YP_002343120.1 1780536 R 122587 CDS YP_002343121.1 218768609 907589 complement(1781054..1781251) 1 NC_003116.1 NMA1836, unknown, len: 65aa; hypothetical protein 1781251 907589 NMA1836 Neisseria meningitidis Z2491 hypothetical protein YP_002343121.1 1781054 R 122587 CDS YP_002343122.1 218768610 907588 complement(1781415..1781879) 1 NC_003116.1 NMA1837, unknown, len: 154aa; hypothetical protein 1781879 907588 NMA1837 Neisseria meningitidis Z2491 hypothetical protein YP_002343122.1 1781415 R 122587 CDS YP_002343123.1 218768611 907587 complement(1781866..1782252) 1 NC_003116.1 NMA1838, DNA-binding protein, len: 128aa; contains helix-turn-helix motif 20-41aa (+2.60 SD).; hypothetical protein 1782252 907587 NMA1838 Neisseria meningitidis Z2491 hypothetical protein YP_002343123.1 1781866 R 122587 CDS YP_002343124.1 218768612 907586 complement(1782428..1782802) 1 NC_003116.1 NMA1840, unknown, len: 124aa; hypothetical protein 1782802 907586 NMA1840 Neisseria meningitidis Z2491 hypothetical protein YP_002343124.1 1782428 R 122587 CDS YP_002343125.1 218768613 907585 complement(1782816..1784243) 1 NC_003116.1 NMA1841, unknown, len: 475aa; similar to TR:P79678 (EMBL:AB000833) sheath protein from Bacteriophage Mu (495 aa) fasta scores; E(): 1.1e-10, 30.8% identity in 500 aa overlap.; hypothetical protein 1784243 907585 NMA1841 Neisseria meningitidis Z2491 hypothetical protein YP_002343125.1 1782816 R 122587 CDS YP_002343126.1 218768614 907583 complement(1784243..1784431) 1 NC_003116.1 NMA1842, unknown, len: 62aa; hypothetical protein 1784431 907583 NMA1842 Neisseria meningitidis Z2491 hypothetical protein YP_002343126.1 1784243 R 122587 CDS YP_002343127.1 218768615 907582 complement(1784428..1785096) 1 NC_003116.1 NMA1843, unknown, len: 222aa; hypothetical protein 1785096 907582 NMA1843 Neisseria meningitidis Z2491 hypothetical protein YP_002343127.1 1784428 R 122587 CDS YP_002343128.1 218768616 907581 complement(1785080..1785505) 1 NC_003116.1 NMA1844, unknown, len: 141aa; similar to SW:P44230 (YF08_HAEIN) hypothetical protein from Haemophilus influenzae (141 aa) fasta scores; E(): 7.3e-10, 32.8% identity in 137 aa overlap.; hypothetical protein 1785505 907581 NMA1844 Neisseria meningitidis Z2491 hypothetical protein YP_002343128.1 1785080 R 122587 CDS YP_002343129.1 218768617 907580 complement(1785502..1785975) 1 NC_003116.1 NMA1845, unknown, len: 157aa; contains coiled-coil region in the N-terminal half.; hypothetical protein 1785975 907580 NMA1845 Neisseria meningitidis Z2491 hypothetical protein YP_002343129.1 1785502 R 122587 CDS YP_002343130.1 218768618 907577 complement(1786013..1786915) 1 NC_003116.1 NMA1847, conserved hypothetical protein, len: 300aa; similar to SW:P44230 (YF05_HAEIN) hypothetical protein from Haemophilus influenzae (308 aa) fasta scores; E(): 0, 53.6% identity in 306 aa overlap.; hypothetical protein 1786915 907577 NMA1847 Neisseria meningitidis Z2491 hypothetical protein YP_002343130.1 1786013 R 122587 CDS YP_002343131.1 218768619 907576 complement(1786937..1788001) 1 NC_003116.1 NMA1848, hypothetical protein, len: 354aa; similar to SW:O05073 (VPI_HAEIN) cryptic Mu phage I protein from Haemophilus influenzae (355 aa) fasta scores; E(): 2.2e-15, 32.2% identity in 360 aa overlap.; hypothetical protein 1788001 907576 NMA1848 Neisseria meningitidis Z2491 hypothetical protein YP_002343131.1 1786937 R 122587 CDS YP_002343132.1 218768620 907575 complement(1788210..1788707) 1 NC_003116.1 NMA1849, unknown, len: 165aa; similar to SW:P45255 (VPG2_HAEIN) hypothetical protein from Haemophilus influenzae (138 aa) fasta scores; E(): 5.6e-11, 38.4% identity in 164 aa overlap.; hypothetical protein 1788707 907575 NMA1849 Neisseria meningitidis Z2491 hypothetical protein YP_002343132.1 1788210 R 122587 CDS YP_002343133.1 218768621 907574 complement(1788811..1790157) 1 NC_003116.1 NMA1850, unknown, len: 448aa; weakly similar to SW:P44226 (YF02_HAEIN) hypothetical protein from Haemophilus influenzae (414 aa) fasta scores; E(): 7.9e-18, 27.3% identity in 362 aa overlap.; hypothetical protein 1790157 907574 NMA1850 Neisseria meningitidis Z2491 hypothetical protein YP_002343133.1 1788811 R 122587 CDS YP_002343134.1 218768622 907573 complement(1790150..1791709) 1 NC_003116.1 NMA1851, conserved hypothetical protein, len: 519aa; similar to SW:P44225 (YF01_HAEIN) hypothetical protein from Haemophilus influenzae (520 aa) fasta scores; E(): 0, 46.2% identity in 511 aa overlap.; hypothetical protein 1791709 907573 NMA1851 Neisseria meningitidis Z2491 hypothetical protein YP_002343134.1 1790150 R 122587 CDS YP_002343135.1 218768623 907572 complement(1791788..1793407) 1 NC_003116.1 NMA1852, unknown, len: 539aa; hypothetical protein 1793407 907572 NMA1852 Neisseria meningitidis Z2491 hypothetical protein YP_002343135.1 1791788 R 122587 CDS YP_002343136.1 218768624 907571 1793419..1793613 1 NC_003116.1 NMA1853, unknown, len: 64aa; hypothetical protein 1793613 907571 NMA1853 Neisseria meningitidis Z2491 hypothetical protein YP_002343136.1 1793419 D 122587 CDS YP_002343137.1 218768625 907569 complement(1793610..1794116) 1 NC_003116.1 NMA1854, DNA-binding protein, len: 168aa; contains helix-turn-helix motif 21-42aa (+3.63 SD).; hypothetical protein 1794116 907569 NMA1854 Neisseria meningitidis Z2491 hypothetical protein YP_002343137.1 1793610 R 122587 CDS YP_002343138.1 218768626 907568 complement(1794119..1794334) 1 NC_003116.1 NMA1855, unknown, len: 71aa; hypothetical protein 1794334 907568 NMA1855 Neisseria meningitidis Z2491 hypothetical protein YP_002343138.1 1794119 R 122587 CDS YP_002343139.1 218768627 907567 complement(1794334..1794615) 1 NC_003116.1 NMA1856, unknown, len: 93aa; contains hydrophilic,hydrophobic and coiled-coil regions.; hypothetical protein 1794615 907567 NMA1856 Neisseria meningitidis Z2491 hypothetical protein YP_002343139.1 1794334 R 122587 CDS YP_002343140.1 218768628 907566 complement(1794612..1794953) 1 NC_003116.1 NMA1857, unknown, len: 113aa; hypothetical protein 1794953 907566 NMA1857 Neisseria meningitidis Z2491 hypothetical protein YP_002343140.1 1794612 R 122587 CDS YP_002343141.1 218768629 907565 complement(1794950..1795168) 1 NC_003116.1 NMA1858, duplicated hypothetical protein, len: 72aa; identical to (but shorter than) another from Neisseria meningitidis NMA1194 fasta scores; E(): 1.8e-32, 100.0% identity in 72 aa overlap.; hypothetical protein 1795168 907565 NMA1858 Neisseria meningitidis Z2491 hypothetical protein YP_002343141.1 1794950 R 122587 CDS YP_002343142.1 218768630 907564 1795181..1795351 1 NC_003116.1 NMA1859, duplicated hypothetical protein, len: 56aa; identical to another from Neisseria meningitidis NMA1193 fasta scores; E(): 6e-26, 100.0% identity in 56 aa overlap.; hypothetical protein 1795351 907564 NMA1859 Neisseria meningitidis Z2491 hypothetical protein YP_002343142.1 1795181 D 122587 CDS YP_002343143.1 218768631 907562 complement(1795396..1795578) 1 NC_003116.1 NMA1860, duplicated hypothetical protein, len: 60aa; almost identical to another from Neisseria meningitidis NMA1192 fasta scores; E(): 8e-26, 98.3% identity in 60 aa overlap.; hypothetical protein 1795578 907562 NMA1860 Neisseria meningitidis Z2491 hypothetical protein YP_002343143.1 1795396 R 122587 CDS YP_002343144.1 218768632 907561 complement(1795598..1796017) 1 NC_003116.1 NMA1861, duplicated hypothetical protein, len: aa; identical/almost identical to two others in Neisseria meningitidis; NMA1306 fasta scores; E(): 0, 100.0% identity in 139 aa overlap and NMA1191 fasta scores; E(): 0, 97.1% identity in 139 aa overlap.; hypothetical protein 1796017 907561 NMA1861 Neisseria meningitidis Z2491 hypothetical protein YP_002343144.1 1795598 R 122587 CDS YP_002343145.1 218768633 907560 complement(1795989..1796225) 1 NC_003116.1 NMA1862, duplicated hypothetical protein, len: 78aa; identical to two others from Neisseria meningitidis; NMA1190 and NMA1305 fasta scores; E(): 2e-31, 100.0% identity in 78 aa overlap.; hypothetical protein 1796225 907560 NMA1862 Neisseria meningitidis Z2491 hypothetical protein YP_002343145.1 1795989 R 122587 CDS YP_002343146.1 218768634 907559 complement(1796228..1796392) 1 NC_003116.1 NMA1863, duplicated hypothetical protein, len: 54aa; identical to two others from Neisseria meningitidis; NMA1189 and NMA1304 fasta scores; E(): 1.7e-22, 100.0% identity in 54 aa overlap.; hypothetical protein 1796392 907559 NMA1863 Neisseria meningitidis Z2491 hypothetical protein YP_002343146.1 1796228 R 122587 CDS YP_002343147.1 218768635 907558 complement(1796598..1797143) 1 NC_003116.1 NMA1864, duplicated hypothetical protein, len: 54aa; almost identical to two others from Neisseria meningitidis; NMA1188 and NMA1303 fasta scores; E(): 0,96.7% identity in 181 aa overlap.; hypothetical protein 1797143 907558 NMA1864 Neisseria meningitidis Z2491 hypothetical protein YP_002343147.1 1796598 R 122587 CDS YP_002343148.1 218768636 907553 complement(1797275..1797952) 1 NC_003116.1 NMA1865, unknown, len: 225aa; hypothetical protein 1797952 907553 NMA1865 Neisseria meningitidis Z2491 hypothetical protein YP_002343148.1 1797275 R 122587 CDS YP_002343149.1 218768637 907552 complement(1797964..1798410) 1 NC_003116.1 NMA1866, integral membrane protein, len: 148aa; contains membrane-spanning hydrophobic region.; integral membrane protein 1798410 907552 NMA1866 Neisseria meningitidis Z2491 integral membrane protein YP_002343149.1 1797964 R 122587 CDS YP_002343150.1 218768638 907551 complement(1798407..1798886) 1 NC_003116.1 NMA1867, unknown, len: 159aa; hypothetical protein 1798886 907551 NMA1867 Neisseria meningitidis Z2491 hypothetical protein YP_002343150.1 1798407 R 122587 CDS YP_002343151.1 218768639 907549 complement(1798917..1799192) 1 NC_003116.1 NMA1868, hupB2, DNA-binding protein HU-beta, len: 91aa; strongly similar to many eg. SW:P02341 (DBHB_ECOLI) DNA-binding protein HU-beta from Escherichia coli (90 aa) fasta scores; E(): 7.1e-17, 57.8% identity in 90 aa overlap. Contains Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein.; DNA-binding protein HU-beta 1799192 907549 NMA1868 Neisseria meningitidis Z2491 DNA-binding protein HU-beta YP_002343151.1 1798917 R 122587 CDS YP_002343152.1 218768640 907548 complement(1799241..1799441) 1 NC_003116.1 NMA1869, unknown, len: 66aa; hypothetical protein 1799441 907548 NMA1869 Neisseria meningitidis Z2491 hypothetical protein YP_002343152.1 1799241 R 122587 CDS YP_002343153.1 218768641 907547 complement(1799442..1800092) 1 NC_003116.1 NMA1870, unknown, len: 216aa; hypothetical protein 1800092 907547 NMA1870 Neisseria meningitidis Z2491 hypothetical protein YP_002343153.1 1799442 R 122587 CDS YP_002343154.1 218768642 907546 complement(1800098..1800709) 1 NC_003116.1 NMA1871, unknown, len: 203aa; hypothetical protein 1800709 907546 NMA1871 Neisseria meningitidis Z2491 hypothetical protein YP_002343154.1 1800098 R 122587 CDS YP_002343155.1 218768643 907545 complement(1800702..1800896) 1 NC_003116.1 NMA1872, unknown, len: 64aa; hypothetical protein 1800896 907545 NMA1872 Neisseria meningitidis Z2491 hypothetical protein YP_002343155.1 1800702 R 122587 CDS YP_002343156.1 218768644 907544 complement(1800868..1801323) 1 NC_003116.1 NMA1873, unknown, len: 151aa; hypothetical protein 1801323 907544 NMA1873 Neisseria meningitidis Z2491 hypothetical protein YP_002343156.1 1800868 R 122587 CDS YP_002343157.1 218768645 907543 complement(1801307..1801684) 1 NC_003116.1 NMA1874, unknown, len: 125aa; hypothetical protein 1801684 907543 NMA1874 Neisseria meningitidis Z2491 hypothetical protein YP_002343157.1 1801307 R 122587 CDS YP_002343158.1 218768646 907542 complement(1801803..1802117) 1 NC_003116.1 NMA1875, unknown, len: 104aa; hypothetical protein 1802117 907542 NMA1875 Neisseria meningitidis Z2491 hypothetical protein YP_002343158.1 1801803 R 122587 CDS YP_002343159.1 218768647 907541 complement(1802114..1802329) 1 NC_003116.1 NMA1876, unknown, len: 71aa; hypothetical protein 1802329 907541 NMA1876 Neisseria meningitidis Z2491 hypothetical protein YP_002343159.1 1802114 R 122587 CDS YP_002343160.1 218768648 907540 complement(1802310..1802474) 1 NC_003116.1 NMA1877, small secreted protein, len: 54aa; contains a non-cleavable N-terminal signal sequence.; small secreted protein 1802474 907540 NMA1877 Neisseria meningitidis Z2491 small secreted protein YP_002343160.1 1802310 R 122587 CDS YP_002343161.1 218768649 907539 complement(1802490..1802642) 1 NC_003116.1 NMA1878, unknown, len: 50aa; hypothetical protein 1802642 907539 NMA1878 Neisseria meningitidis Z2491 hypothetical protein YP_002343161.1 1802490 R 122587 CDS YP_002343162.1 218768650 907538 complement(1802645..1802944) 1 NC_003116.1 NMA1879, unknown, len: 99aa; hypothetical protein 1802944 907538 NMA1879 Neisseria meningitidis Z2491 hypothetical protein YP_002343162.1 1802645 R 122587 CDS YP_002343163.1 218768651 907537 complement(1802934..1803176) 1 NC_003116.1 NMA1880, unknown, len: 80aa; hypothetical protein 1803176 907537 NMA1880 Neisseria meningitidis Z2491 hypothetical protein YP_002343163.1 1802934 R 122587 CDS YP_002343164.1 218768652 907536 complement(1803252..1804166) 1 NC_003116.1 NMA1881, DNA-binding protein, len: 304aa; similar to SW:P96343 (VPB_HAEIN) cryptic Mu-phage DNA transposition protein from Haemophilus influenzae (287 aa) fasta scores; E(): 2.4e-17, 30.6% identity in 281 aa overlap. Contains helix-turn-helix motif 15-36aa (+6.22 SD).; hypothetical protein 1804166 907536 NMA1881 Neisseria meningitidis Z2491 hypothetical protein YP_002343164.1 1803252 R 122587 CDS YP_002343165.1 218768653 907535 complement(1804208..1806253) 1 NC_003116.1 NMA1882, transposase, len: 681aa; similar to TR:Q38013 (EMBL:X87627) transposase from Bacteriophage D3112 of Pseudomonas aeruginosa (690 aa) fasta scores; E(): 3.6e-26, 32.6% identity in 671 aa overlap. Also highly similar to TR:P72094 (EMBL:U56765) transposase homolog (fragment) from Neisseria meningitidis (90 aa) fasta scores; E(): 3.9e-29, 98.9% identity in 90 aa overlap.; transposase 1806253 907535 NMA1882 Neisseria meningitidis Z2491 transposase YP_002343165.1 1804208 R 122587 CDS YP_002343166.1 218768654 907534 complement(1806331..1806594) 1 NC_003116.1 NMA1883, Ner-like DNA-binding protein, len: 87aa; similar to others eg. SW:P06020 (DBNE_BPMU) DNA-binding protein Ner from Bacteriophage Mu (74 aa) fasta scores; E(): 1.2e-10, 51.5% identity in 68 aa overlap. Contains helix-turn-helix motif 25-46aa (+4.35 SD).; Ner-like DNA-binding protein 1806594 907534 NMA1883 Neisseria meningitidis Z2491 Ner-like DNA-binding protein YP_002343166.1 1806331 R 122587 CDS YP_002343167.1 218768655 907533 1806811..1807515 1 NC_003116.1 NMA1884, regulator, len: 234aa; similar to others eg. SW:P14819 (RPC1_BPPH8) repressor protein CI from Bacteriophage phi-80 (235 aa) fasta scores; E(): 4.4e-09, 29.3% identity in 232 aa overlap.; regulator 1807515 907533 NMA1884 Neisseria meningitidis Z2491 regulator YP_002343167.1 1806811 D 122587 CDS YP_002343168.1 218768656 907532 complement(1807617..1807775) 1 NC_003116.1 NMA1885, unknown, len: 52aa; hypothetical protein 1807775 907532 NMA1885 Neisseria meningitidis Z2491 hypothetical protein YP_002343168.1 1807617 R 122587 CDS YP_002343169.1 218768657 907531 complement(1807779..1810034) 1 NC_003116.1 NMA1886, nor, nitric oxide reductase, len: 751aa; similar to many eg. TR:O30368 (EMBL:AF002217) nitric oxide reductase from Alcaligenes eutrophus (762 aa) fasta scores; E(): 0, 61.2% identity in 752 aa overlap. Contains Prosite match to PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature and membrane-spanning hydrophobic regions.; nitric oxide reductase 1810034 907531 NMA1886 Neisseria meningitidis Z2491 nitric oxide reductase YP_002343169.1 1807779 R 122587 CDS YP_002343170.1 218768658 907183 1810404..1811564 1 NC_003116.1 NMA1887, aniA, nitrite reductase, major outer membrane copper-containing protein, len: 386aa; similar to many egs. SW:Q02219 (ANIA_NEIGO) major outer membrane protein from Neisseria gonorrhoeae (392 aa) fasta scores; E(): 0, 95.7% identity in 392 aa overlap and SW:P25006 (NIR_ACHCY) copper-containing nitrite reductase from Achromobacter cycloclastes (378 aa) fasta scores; E(): 1.2e-17, 36.4% identity in 365 aa overlap. Contains a cleavable N-terminal signal sequence and Pfam match to entry PF00394 Cu-oxidase, Multicopper oxidase and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; nitrite reductase, major outer membrane copper-containing protein 1811564 907183 NMA1887 Neisseria meningitidis Z2491 nitrite reductase, major outer membrane copper-containing protein YP_002343170.1 1810404 D 122587 CDS YP_002343171.1 218768659 908134 1811744..1812499 1 NC_003116.1 NMA1888, unknown, len: 251aa; hypothetical protein 1812499 908134 NMA1888 Neisseria meningitidis Z2491 hypothetical protein YP_002343171.1 1811744 D 122587 CDS YP_002343172.1 218768660 907529 complement(1816250..1816807) 1 NC_003116.1 NMA1891, conserved hypothetical protein, len: 185aa; previously sequenced therefore identical to TR:O34773 (EMBL:AF004825) hypothetical protein from Neisseria meningitidis serogroup A (185 aa) fasta scores; E(): 0, 100.0% identity in 185 aa overlap. Also similar to other hypothetical proteins eg. SW:P45244 (YDJA_HAEIN) hypothetical protein from Haemophilus influenzae (184 aa) fasta scores; E(): 0, 50.3% identity in 185 aa overlap.; hypothetical protein 1816807 907529 NMA1891 Neisseria meningitidis Z2491 hypothetical protein YP_002343172.1 1816250 R 122587 CDS YP_002343173.1 218768661 906613 complement(1816883..1818517) 1 NC_003116.1 NMA1892, conserved hypothetical protein, len: 544aa; previously sequenced therefore identical to TR:O34609 (EMBL:AF004825) hypothetical protein from Neisseria meningitidis serogroup A (544 aa) fasta scores; E(): 0, 100.0% identity in 544 aa overlap. Also similar to many other hypothetical proteins eg. SW:P30845 (YJDB_ECOLI) hypothetical protein from Escherichia coli (547 aa) fasta scores; E(): 0, 44.2% identity in 547 aa overlap.; hypothetical protein 1818517 906613 NMA1892 Neisseria meningitidis Z2491 hypothetical protein YP_002343173.1 1816883 R 122587 CDS YP_002343174.1 218768662 906313 complement(1818798..1819904) 1 NC_003116.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1819904 serC 906313 serC Neisseria meningitidis Z2491 phosphoserine aminotransferase YP_002343174.1 1818798 R 122587 CDS YP_002343175.1 218768663 907528 1820251..1820700 1 NC_003116.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 1820700 907528 NMA1895 Neisseria meningitidis Z2491 hypothetical protein YP_002343175.1 1820251 D 122587 CDS YP_002343176.1 218768664 907527 1820713..1822230 1 NC_003116.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1822230 nusA 907527 nusA Neisseria meningitidis Z2491 transcription elongation factor NusA YP_002343176.1 1820713 D 122587 CDS YP_002343177.1 218768665 907526 1822242..1825130 1 NC_003116.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1825130 infB 907526 infB Neisseria meningitidis Z2491 translation initiation factor IF-2 YP_002343177.1 1822242 D 122587 CDS YP_002343178.1 218768666 907525 complement(1825341..1826735) 1 NC_003116.1 NMA1898, integral membrane protein, len: 464aa; N-terminal similar to that of SW:P17196 (EF1A_SULAC) elongation factor 1-alpha from Sulfolobus acidocaldarius (435 aa) fasta scores; E(): 0.25, 31.0% identity in 129 aa overlap. Contains membrane-spanning hydrophobic region.; integral membrane protein 1826735 907525 NMA1898 Neisseria meningitidis Z2491 integral membrane protein YP_002343178.1 1825341 R 122587 CDS YP_002343179.1 218768667 907524 complement(1826797..1828146) 1 NC_003116.1 NMA1899, integral membrane protein, len: 449aa; contains membrane-spanning hydrophobic regions.; integral membrane protein 1828146 907524 NMA1899 Neisseria meningitidis Z2491 integral membrane protein YP_002343179.1 1826797 R 122587 CDS YP_002343180.1 218768668 907522 1828289..1828915 1 NC_003116.1 NMA1900, haemolysin, len: 208aa; similar to SW:P54176 (HLY3_BACCE) hemolysin III from Bacillus cereus (219 aa) fasta scores; E(): 4e-30, 42.1% identity in 202 aa overlap. Contains membrane-spanning hydrophobic regions.; hemolysin 1828915 907522 NMA1900 Neisseria meningitidis Z2491 hemolysin YP_002343180.1 1828289 D 122587 CDS YP_002343181.1 218768669 907521 complement(1828979..1830397) 1 NC_003116.1 NMA1901, sodium:alanine symporter, len: 472aa; similar to many eg. SW:P30144 (DAGA_ALTHA) Na(+)-linked D-alanine glycine permease (542 aa) fasta scores; E(): 0, 32.6% identity in 537 aa overlap. Contains Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family and Prosite match to PS00873 Sodium:alanine symporter family signature. Also contains membrane-spanning hydrophobic regions.; sodium:alanine symporter 1830397 907521 NMA1901 Neisseria meningitidis Z2491 sodium:alanine symporter YP_002343181.1 1828979 R 122587 CDS YP_002343182.1 218768670 907484 1830724..1831452 1 NC_003116.1 NMA1902, conserved hypothetical protein, len: 242aa; similar to many eg. SW:P24237 (YEBC_ECOLI) hypothetical protein from Escherichia coli (246 aa) fasta scores; E(): 0, 57.7% identity in 234 aa overlap.; hypothetical protein 1831452 907484 NMA1902 Neisseria meningitidis Z2491 hypothetical protein YP_002343182.1 1830724 D 122587 CDS YP_002343183.1 218768671 907520 complement(1831511..1832110) 1 NC_003116.1 NMA1903, disulphide bond formation protein, len: 199aa; similar to many eg. SW:P30018 (DSBB_ECOLI) disulphide bond formation protein B from Escherichia coli (176 aa) fasta scores; E(): 4.2e-08,28.6% identity in 161 aa overlap.; disulfide bond formation protein 1832110 907520 NMA1903 Neisseria meningitidis Z2491 disulfide bond formation protein YP_002343183.1 1831511 R 122587 CDS YP_002343184.1 218768672 907518 complement(1832690..1833154) 1 NC_003116.1 NMA1905, AsnC-family transcriptional regulator,len: 154aa; similar to many eg. SW:P19494 (LRP_ECOLI) Lrp leucine-responsive regulatory protein from Escherichia coli (163 aa) fasta scores; E(): 3.7e-31, 56.5% identity in 147 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg, AsnC family.; AsnC family transcriptional regulator 1833154 907518 NMA1905 Neisseria meningitidis Z2491 AsnC family transcriptional regulator YP_002343184.1 1832690 R 122587 CDS YP_002343185.1 218768673 907517 1833479..1834537 1 NC_003116.1 NMA1906, alr, alanine racemase, len: 377aa; similar to many eg. SW:P06655 (ALR1_SALTY) alr, alanine racemase from Salmonella typhimurium (359 aa) fasta scores; E(): 0,41.7% identity in 360 aa overlap. Contains Pfam match to entry PF00842 Ala_racemase, Alanine racemase and Prosite match to PS00395 Alanine racemase pyridoxal-phosphate attachment site.; alanine racemase 1834537 907517 NMA1906 Neisseria meningitidis Z2491 alanine racemase YP_002343185.1 1833479 D 122587 CDS YP_002343186.1 218768674 907514 complement(1835999..1837354) 1 NC_003116.1 NMA1908, conserved hypothetical protein, len: 451aa; similar to TR:Q59059 (EMBL:U67606) hypothetical protein from Methanococcus jannaschii (458 aa) fasta scores; E(): 0, 62.9% identity in 453 aa overlap.; hypothetical protein 1837354 907514 NMA1908 Neisseria meningitidis Z2491 hypothetical protein YP_002343186.1 1835999 R 122587 CDS YP_002343187.1 218768675 907513 complement(1837369..1837641) 1 NC_003116.1 ACT domain-containing protein; hypothetical protein 1837641 907513 NMA1909 Neisseria meningitidis Z2491 hypothetical protein YP_002343187.1 1837369 R 122587 CDS YP_002343188.1 218768676 907512 complement(1837767..1838504) 1 NC_003116.1 NMA1911, periplasmic protein, len: 245aa; contains a cleavable N-terminal signal sequence.; hypothetical protein 1838504 907512 NMA1911 Neisseria meningitidis Z2491 hypothetical protein YP_002343188.1 1837767 R 122587 CDS YP_002343189.1 218768677 907511 complement(1838785..1839696) 1 NC_003116.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1839696 907511 NMA1912 Neisseria meningitidis Z2491 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002343189.1 1838785 R 122587 CDS YP_002343190.1 218768678 907510 1839829..1840422 1 NC_003116.1 NMA1913, unknown, len: 197aa; hypothetical protein 1840422 907510 NMA1913 Neisseria meningitidis Z2491 hypothetical protein YP_002343190.1 1839829 D 122587 CDS YP_002343191.1 218768679 907509 1840534..1841154 1 NC_003116.1 NMA1914, unknown, len: 206aa; hypothetical protein 1841154 907509 NMA1914 Neisseria meningitidis Z2491 hypothetical protein YP_002343191.1 1840534 D 122587 CDS YP_002343192.1 218768680 907508 complement(1841085..1841549) 1 NC_003116.1 NMA1915, DNA transport competence protein,len: 154 aa; region of similarity to SW:P39694 (CME1_BACSU) ComE a late competence operon protein from Bacillus subtilis (205 aa) fasta scores; E(): 9.8e-07,47.6% identity in 63 aa overlap. Previously sequenced therefore almost identical to TR:CAB44958 (EMBL:AJ242837) ComEA protein (fragment) from Neisseria meningitidis serogroup A strain Z2491 (170 aa) fasta scores; E(): 0,100.0% identity in 154 aa overlap. Contains Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif and membrane-spanning hydrophobic region. Identical to NMA2187, and almost identical to NMA0211 (98.7% identity in 154 aa overlap), and NMA0423 (98.7% identity in 154 aa overlap); DNA transport competence protein 1841549 907508 NMA1915 Neisseria meningitidis Z2491 DNA transport competence protein YP_002343192.1 1841085 R 122587 CDS YP_002343193.1 218768681 907507 1847422..1848606 1 NC_003116.1 NMA1916, unknown, len: 394aa; similar to many proposed DNA/pantothenate metabolism flavoproteins eg. SW:P24285 (DFP_ECOLI) from Escherichia coli (430 aa) fasta scores; E(): 0, 39.7% identity in 383 aa overlap.; hypothetical protein 1848606 907507 NMA1916 Neisseria meningitidis Z2491 hypothetical protein YP_002343193.1 1847422 D 122587 CDS YP_002343194.1 218768682 907506 complement(1848673..1850829) 1 NC_003116.1 NMA1917, spoT, guanosine-3',5'-bis(diphosphate) 3'-pyrophophohydrolase, len: 725aa; similar to many eg. SW:P17580 (SPOT_ECOLI) spoT,guanosine-3',5'-bis(diphosphate) 3'-pyrophophohydrolase from Escherichia coli (702 aa) fasta scores; E(): 0, 45.6% identity in 697 aa overlap.; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 1850829 907506 NMA1917 Neisseria meningitidis Z2491 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase YP_002343194.1 1848673 R 122587 CDS YP_002343195.1 218768683 907505 complement(1850922..1851128) 1 NC_003116.1 NMA1918, rpoZ, DNA-directed RNA polymerase omega chain, len: 68aa; similar to SW:P08374 (RPOZ_ECOLI) rpoZ,DNA-directed RNA polymerase omega chain from Escherichia coli (91 aa) fasta scores; E(): 3.1e-10, 55.4% identity in 65 aa overlap.; DNA-directed RNA polymerase subunit omega 1851128 907505 NMA1918 Neisseria meningitidis Z2491 DNA-directed RNA polymerase subunit omega YP_002343195.1 1850922 R 122587 CDS YP_002343196.1 218768684 907504 complement(1851187..1851804) 1 NC_003116.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1851804 gmk 907504 gmk Neisseria meningitidis Z2491 guanylate kinase YP_002343196.1 1851187 R 122587 CDS YP_002343197.1 218768685 907503 1851932..1852531 1 NC_003116.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1852531 apt 907503 apt Neisseria meningitidis Z2491 adenine phosphoribosyltransferase YP_002343197.1 1851932 D 122587 CDS YP_002343198.1 218768686 907186 complement(1852577..1853386) 1 NC_003116.1 NMA1921, conserved hypothetical protein, len: 269aa; similar to many hypothetical proteins eg. TR:Q45494 (EMBL:AF012285) hypothetical protein from Bacillus subtilis (257 aa) fasta scores; E(): 1.7e-25, 32.6% identity in 264 aa overlap. Contains Pfam match to entry PF00592 DUF3, Domain of Unknown Function 3 and Prosite match to PS01229 Hypothetical cof family signature 2.; hypothetical protein 1853386 907186 NMA1921 Neisseria meningitidis Z2491 hypothetical protein YP_002343198.1 1852577 R 122587 CDS YP_002343199.1 218768687 907502 1853690..1855045 1 NC_003116.1 NMA1923, probable protease, len: 451aa; similar to many eg. SW:P76403 (YEGQ_ECOLI) protease from Escherichia coli (453 aa) fasta scores; E(): 0, 60.0% identity in 450 aa overlap. Contains Pfam match to entry PF01136 Peptidase_U32, Peptidase family U32 and Prosite match to PS01276 Peptidase family U32 signature.; protease 1855045 907502 NMA1923 Neisseria meningitidis Z2491 protease YP_002343199.1 1853690 D 122587 CDS YP_002343200.1 218768688 907501 1855179..1855655 1 NC_003116.1 NMA1924, unknown, len: 158aa; hypothetical protein 1855655 907501 NMA1924 Neisseria meningitidis Z2491 hypothetical protein YP_002343200.1 1855179 D 122587 CDS YP_002343201.1 218768689 906589 complement(1858414..1859106) 1 NC_003116.1 NMA1927, hemO, haem utilisation protein, len: 230aa; similar to TR:O69002 (EMBL:AF060193) PigA, iron starvation protein from Pseudomonas aeruginosa (198 aa) fasta scores; E(): 1.3e-20, 37.8% identity in 196 aa overlap. Identified as haem utilisation protein by Zhu et al, J. Bact 182, 439-447 (2000); heme utilisation protein 1859106 906589 NMA1927 Neisseria meningitidis Z2491 heme utilisation protein YP_002343201.1 1858414 R 122587 CDS YP_002343202.1 218768690 907192 1859536..1860840 1 NC_003116.1 NMA1928, hypothetical integral membrane protein,len: 434aa; similar to SW:P43670 (PQIA_ECOLI) paraquat-inducible protein from Escherichia coli (417 aa) fasta scores; E(): 0, 31.9% identity in 414 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1860840 907192 NMA1928 Neisseria meningitidis Z2491 hypothetical protein YP_002343202.1 1859536 D 122587 CDS YP_002343203.1 218768691 907188 1860833..1862494 1 NC_003116.1 NMA1929, hypothetical integral membrane protein,len: 553aa; similar to SW:P43671 (PQIB_ECOLI) paraquat-inducible protein from Escherichia coli (546 aa) fasta scores; E(): 0, 37.0% identity in 549 aa overlap. Contains membrane-spanning hydrophobic regions and a coiled-coil region.; hypothetical protein 1862494 907188 NMA1929 Neisseria meningitidis Z2491 hypothetical protein YP_002343203.1 1860833 D 122587 CDS YP_002343204.1 218768692 907499 1862494..1863012 1 NC_003116.1 NMA1930, lipoprotein, len: 172aa; similar to SW:P75866 (YMBA_ECOLI) hypothetical protein from Escherichia coli (182 aa) fasta scores; E(): 6.3e-08,30.1% identity in 173 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein 1863012 907499 NMA1930 Neisseria meningitidis Z2491 lipoprotein YP_002343204.1 1862494 D 122587 CDS YP_002343205.1 218768693 907498 1863016..1863567 1 NC_003116.1 NMA1931, tag, DNA-3-methyladenine glycosylase I,len: 183aa; similar to many eg. SW:P05100 (3MG1_ECOLI) tag, DNA-3-methyladenine glycosylase I from Escherichia coli (187 aa) fasta scores; E(): 4.1e-13, 39.3% identity in 168 aa overlap.; DNA-3-methyladenine glycosylase I 1863567 907498 NMA1931 Neisseria meningitidis Z2491 DNA-3-methyladenine glycosylase I YP_002343205.1 1863016 D 122587 CDS YP_002343206.1 218768694 907523 1863557..1864198 1 NC_003116.1 NMA1932, lipase, len: 213aa; similar to SW:P29679 (TESA_ECOLI) acyl-CoA thioesterase I from Escherichia coli (208 aa) fasta scores; E(): 1.6e-11,34.9% identity in 172 aa overlap. Contains Pfam match to entry PF00657 Lipase_GDSL, Lipase/Acylhydrolase with GDSL-like motif.; lipase 1864198 907523 NMA1932 Neisseria meningitidis Z2491 lipase YP_002343206.1 1863557 D 122587 CDS YP_002343207.1 218768695 906035 1864473..1864832 1 NC_003116.1 NMA1933, integral membrane protein, len: 119aa; contains membrane-spanning hydrophobic regions.; integral membrane protein 1864832 906035 NMA1933 Neisseria meningitidis Z2491 integral membrane protein YP_002343207.1 1864473 D 122587 CDS YP_002343208.1 218768696 906146 1864863..1867715 1 NC_003116.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 1867715 gcvP 906146 gcvP Neisseria meningitidis Z2491 glycine dehydrogenase YP_002343208.1 1864863 D 122587 CDS YP_002343209.1 218768697 907496 complement(1868180..1869019) 1 NC_003116.1 NMA1936, probable cytochrome, len: 279aa; regions similar to many smaller cytochromes eg. SW:P00123 (C555_CHLLT) cytochromes c-555 from Chlorobium limicola f.sp. thiosulfatophilum (86 aa) fasta scores; E(): 9.9e-06, 41.3% identity in 80 aa overlap. Contains two Pfam matches to entry PF00034 cytochrome_c, Cytochrome c and two Prosite matches to PS00190 Cytochrome c family heme-binding site signature.; cytochrome 1869019 907496 NMA1936 Neisseria meningitidis Z2491 cytochrome YP_002343209.1 1868180 R 122587 CDS YP_002343210.1 218768698 907495 complement(1869444..1870637) 1 NC_003116.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1870637 tyrB 907495 tyrB Neisseria meningitidis Z2491 aromatic amino acid aminotransferase YP_002343210.1 1869444 R 122587 CDS YP_002343211.1 218768699 907494 complement(1870658..1871746) 1 NC_003116.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 1871746 trmA 907494 trmA Neisseria meningitidis Z2491 tRNA (uracil-5-)-methyltransferase YP_002343211.1 1870658 R 122587 CDS YP_002343212.1 218768700 907493 1871893..1872993 1 NC_003116.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1872993 aroC 907493 aroC Neisseria meningitidis Z2491 chorismate synthase YP_002343212.1 1871893 D 122587 CDS YP_002343213.1 218768701 907492 1873085..1873510 1 NC_003116.1 NMA1940, unknown, len: 141aa; hypothetical protein 1873510 907492 NMA1940 Neisseria meningitidis Z2491 hypothetical protein YP_002343213.1 1873085 D 122587 CDS YP_002343214.1 218768702 907491 complement(1873584..1875569) 1 NC_003116.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1875569 parE 907491 parE Neisseria meningitidis Z2491 DNA topoisomerase IV subunit B YP_002343214.1 1873584 R 122587 CDS YP_002343215.1 218768703 907490 complement(1875636..1876160) 1 NC_003116.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 1876160 907490 NMA1942 Neisseria meningitidis Z2491 dinucleoside polyphosphate hydrolase YP_002343215.1 1875636 R 122587 CDS YP_002343216.1 218768704 907489 1876325..1877620 1 NC_003116.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1877620 serS 907489 serS Neisseria meningitidis Z2491 seryl-tRNA synthetase YP_002343216.1 1876325 D 122587 CDS YP_002343217.1 218768705 907488 complement(1877693..1878691) 1 NC_003116.1 NMA1944, ldhA, D-lactate dehydrogenase, len: 332aa; similar to many eg. SW:P52643 (LDHD_ECOLI) ldhA, D-lactate dehydrogenase from Escherichia coli (329 aa) fasta scores; E(): 0, 72.7% identity in 326 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases; Prosite match to PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3; Prosite match to PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2 and Prosite match to PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.; D-lactate dehydrogenase 1878691 907488 NMA1944 Neisseria meningitidis Z2491 D-lactate dehydrogenase YP_002343217.1 1877693 R 122587 CDS YP_002343218.1 218768706 907487 complement(1878816..1879892) 1 NC_003116.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1879892 prfA 907487 prfA Neisseria meningitidis Z2491 peptide chain release factor 1 YP_002343218.1 1878816 R 122587 CDS YP_002343219.1 218768707 906595 complement(1879996..1880850) 1 NC_003116.1 NMA1946, conserved hypothetical protein, len: 284aa; note alternative downstream translational start. Similar to many eg. SW:P39408 (YJJV_ECOLI) hypothetical protein from Escherichia coli (259 aa) fasta scores; E(): 4.2e-23, 33.3% identity in 261 aa overlap. Contains Pfam match to entry PF01026 UPF0006,Uncharacterized protein family.; hypothetical protein 1880850 906595 NMA1946 Neisseria meningitidis Z2491 hypothetical protein YP_002343219.1 1879996 R 122587 CDS YP_002343220.1 218768708 906683 complement(1880890..1881879) 1 NC_003116.1 NMA1947, ans, L-asparaginase, len: 329aa; similar to many eg. SW:P18840 (ASG1_ECOLI) ansA, L-asparaginase I from Escherichia coli (338 aa) fasta scores; E(): 3.6e-28,32.6% identity in 334 aa overlap. Contains Pfam match to entry PF00710 Asparaginase, Asparaginase; Prosite match to PS00144 Asparaginase / glutaminase active site signature 1 and Prosite match to PS00917 Asparaginase / glutaminase active site signature 2.; L-asparaginase 1881879 906683 NMA1947 Neisseria meningitidis Z2491 L-asparaginase YP_002343220.1 1880890 R 122587 CDS YP_002343221.1 218768709 907486 complement(1881946..1882731) 1 NC_003116.1 NMA1948, DedA-family integral membrane protein,len: 261aa; similar to many eg. SW:P45280 (YG29_HAEIN) hypothetical protein from Haemophilus influenzae (212 aa) fasta scores; E(): 0, 58.5% identity in 183 aa overlap. Contains Pfam match to entry PF00597 DedA, DedA family. Also contains membrane-spanning hydrophobic regions.; DedA-family integral membrane protein 1882731 907486 NMA1948 Neisseria meningitidis Z2491 DedA-family integral membrane protein YP_002343221.1 1881946 R 122587 CDS YP_002343222.1 218768710 906601 complement(1882819..1884153) 1 NC_003116.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1884153 glmM 906601 glmM Neisseria meningitidis Z2491 phosphoglucosamine mutase YP_002343222.1 1882819 R 122587 CDS YP_002343223.1 218768711 907184 complement(1884283..1885134) 1 NC_003116.1 NMA1950, dhpS, dihydropteroate synthase, len: 283aa; similar to many egs. SW:P26282 (DHPS_ECOLI) dhpS,dihydropteroate synthase from Escherichia coli (282 aa) fasta scores; E(): 0, 47.6% identity in 269 aa overlap and SW:Q51161 (DHPS_NEIME) dhpS, dihydropteroate synthase from Neisseria meningitidis (283 aa) fasta scores; E(): 0,91.5% identity in 283 aa overlap. Contains Pfam match to entry PF00809 DHPS, Dihydropteroate synthase and PS00793 Dihydropteroate synthase signature 2.; dihydropteroate synthase 1885134 907184 NMA1950 Neisseria meningitidis Z2491 dihydropteroate synthase YP_002343223.1 1884283 R 122587 CDS YP_002343224.1 218768712 908135 1885301..1887523 1 NC_003116.1 NMA1951, uknown, len: 740aa; similar to SW:U11035 (ASMA_ECOLI) AsmA protein from Escherichia coli (617 aa) fasta scores; E(): 0.0047, 19.0% identity in 695 aa overlap.; hypothetical protein 1887523 908135 NMA1951 Neisseria meningitidis Z2491 hypothetical protein YP_002343224.1 1885301 D 122587 CDS YP_002343225.1 218768713 907483 complement(1887587..1889065) 1 NC_003116.1 NMA1952, conserved hypothetical protein, len: 492aa; similar to many eg. SW:P26615 (YIGC_ECOLI) hypothetical protein from Escherichia coli (497 aa) fasta scores; E(): 0, 71.7% identity in 492 aa overlap.; hypothetical protein 1889065 907483 NMA1952 Neisseria meningitidis Z2491 hypothetical protein YP_002343225.1 1887587 R 122587 CDS YP_002343226.1 218768714 907485 complement(1889085..1889600) 1 NC_003116.1 NMA1953, unknown, len: 171aa; hypothetical protein 1889600 907485 NMA1953 Neisseria meningitidis Z2491 hypothetical protein YP_002343226.1 1889085 R 122587 CDS YP_002343227.1 218768715 907481 complement(1889607..1890041) 1 NC_003116.1 NMA1954, integral membrane protein, len: 144aa; contains membrane-spanning hydrophobic regions.; integral membrane protein 1890041 907481 NMA1954 Neisseria meningitidis Z2491 integral membrane protein YP_002343227.1 1889607 R 122587 CDS YP_002343228.1 218768716 907480 complement(1890339..1890773) 1 NC_003116.1 NMA1955, unknown, len: 144aa; hypothetical protein 1890773 907480 NMA1955 Neisseria meningitidis Z2491 hypothetical protein YP_002343228.1 1890339 R 122587 CDS YP_002343229.1 218768717 907479 1890948..1891616 1 NC_003116.1 NMA1956, insertion element IS1016 transposase, len: 222aa; similar to many eg. TR:Q48208 (EMBL:X58176) insertion sequence IS1016 from Haemophilus influenzae (164 aa) fasta scores; E(): 0, 69.6% identity in 161 aa overlap. Similar to others from Neisseria meningitidis eg. NMA2185, fasta scores; E(): 0, 94.8% identity in 211 aa overlap. Contains helix-turn-helix motif 35-56aa (+4.71 SD).; insertion element IS1016 transposase 1891616 907479 NMA1956 Neisseria meningitidis Z2491 insertion element IS1016 transposase YP_002343229.1 1890948 D 122587 CDS YP_002343230.1 218768718 907478 1891823..1892959 1 NC_003116.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1892959 fabF2 907478 fabF2 Neisseria meningitidis Z2491 3-oxoacyl-ACP synthase YP_002343230.1 1891823 D 122587 CDS YP_002343231.1 218768719 907477 1893157..1893921 1 NC_003116.1 NMA1958, lgtF, beta-1,4-glucosyltransferase, len: 254aa; strongly similar to TR:P95373 (EMBL:U58765) lgtF,beta-1,4-glucosyltransferase from Neisseria meningitidis strain CDC8201085; NMB (252 aa) fasta scores; E(): 0,98.4% identity in 252 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases.; beta-1,4-glucosyltransferase 1893921 907477 NMA1958 Neisseria meningitidis Z2491 beta-1,4-glucosyltransferase YP_002343231.1 1893157 D 122587 CDS YP_002343232.1 218768720 907476 1893922..1894986 1 NC_003116.1 NMA1959, rfaK, alpha 1,2 N-acetylglucosamine transferase, len: 354aa; strongly similar to TR:Q51123 (EMBL:U58765) rfaK, alpha 1,2 N-acetylglucosamine transferase from Neisseria meningitidis strain CDC8201085; NMB (354 aa) fasta scores; E(): 0, 96.3% identity in 354 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1.; alpha 1,2 N-acetylglucosamine transferase 1894986 907476 NMA1959 Neisseria meningitidis Z2491 alpha 1,2 N-acetylglucosamine transferase YP_002343232.1 1893922 D 122587 CDS YP_002343233.1 218768721 907475 1895025..1895195 1 NC_003116.1 NMA1960, unknown, len: 56aa; hypothetical protein 1895195 907475 NMA1960 Neisseria meningitidis Z2491 hypothetical protein YP_002343233.1 1895025 D 122587 CDS YP_002343234.1 218768722 907474 1895373..1896710 1 NC_003116.1 NMA1961, probable integral membrane ion transporter, len: 445aa; similar to many proposed transporteres eg. TR:AAD20893 (EMBL:U58765) sodium/chroride ion channel from Neisseria meningitidis strain CDC8201085; NMB (445 aa) fasta scores; E(): 0,97.5% identity in 445 aa overlap. Contain two Pfam matches to entry PF00209 SNF, Sodium:neurotransmitter symporter family and membrane-spanning hydrophobic regions.; integral membrane ion transporter 1896710 907474 NMA1961 Neisseria meningitidis Z2491 integral membrane ion transporter YP_002343234.1 1895373 D 122587 CDS YP_002343235.1 218768723 907473 complement(1896882..1897541) 1 NC_003116.1 NMA1962, hypothetical periplasmic protein, len: 219aa; similar to many of undefined function eg. TR:O07332 (EMBL:U94899) NosX protein from Sinorhizobium meliloti (321 aa) fasta scores; E(): 7.4e-25, 50.7% identity in 150 aa overlap. Contains a cleavable N-terminal signal sequence.; hypothetical periplasmic protein 1897541 907473 NMA1962 Neisseria meningitidis Z2491 hypothetical periplasmic protein YP_002343235.1 1896882 R 122587 CDS YP_002343236.1 218768724 907191 complement(1897550..1898344) 1 NC_003116.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 1898344 thyA 907191 thyA Neisseria meningitidis Z2491 thymidylate synthase YP_002343236.1 1897550 R 122587 CDS YP_002343237.1 218768725 907187 1898767..1900101 1 NC_003116.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1900101 gdhA 907187 gdhA Neisseria meningitidis Z2491 glutamate dehydrogenase YP_002343237.1 1898767 D 122587 CDS YP_002343238.1 218768726 907471 complement(1900390..1901172) 1 NC_003116.1 NMA1965, GntR-family transcriptional regulator,len: 260aa; similar to many eg. SW:P06957 (PDHR_ECOLI) pyruvate dehydrogenase complex repressor from Escherichia coli (254 aa) fasta scores; E(): 2.9e-24, 36.0% identity in 247 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and Prosite match to PS00043 Bacterial regulatory proteins,gntR family signature.; GntR family transcriptional regulator 1901172 907471 NMA1965 Neisseria meningitidis Z2491 GntR family transcriptional regulator YP_002343238.1 1900390 R 122587 CDS YP_002343239.1 218768727 907472 1901600..1901899 1 NC_003116.1 NMA1966, integral membrane protein, len: 99aa; region similar to regions from lactate permeases eg. SW:P33231 (LLDP_ECOLI) L-lactate permease from Escherichia coli (551 aa) fasta scores; E(): 4.1e-07, 48.6% identity in 70 aa overlap.; integral membrane protein 1901899 907472 NMA1966 Neisseria meningitidis Z2491 integral membrane protein YP_002343239.1 1901600 D 122587 CDS YP_002343240.1 218768728 907470 complement(1902277..1903680) 1 NC_003116.1 NMA1968, mtrE, outer membrane lipoprotein,len: 467aa; similar to many especially TR:Q51006 (EMBL:X95635) implicated in resistance to toxic hydrophobic agents in Neisseria gonorrhoeae (467 aa) fasta scores; E(): 0, 92.1% identity in 467 aa overlap. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and coiled-coil regions.; outer membrane lipoprotein 1903680 907470 NMA1968 Neisseria meningitidis Z2491 outer membrane lipoprotein YP_002343240.1 1902277 R 122587 CDS YP_002343241.1 218768729 907468 complement(1903735..1906938) 1 NC_003116.1 NMA1969, mtrD, probable drug efflux protein, len: 1067aa; strongly similar to TR:Q51073 (EMBL:U60099) MtrD protein from Neisseria gonorrhoeae (1067 aa) fasta scores; E(): 0, 96.8% identity in 1067 aa overlap and SW:P31224 (ACRB_ECOLI) acriflavin resistance protein from Escherichia coli (1049 aa) fasta scores; E(): 0, 49.4% identity in 1063 aa overlap. Contains Pfam match to entry PF00873 ACR_tran, AcrB/AcrD/AcrF family.; drug efflux protein 1906938 907468 NMA1969 Neisseria meningitidis Z2491 drug efflux protein YP_002343241.1 1903735 R 122587 CDS YP_002343242.1 218768730 907467 complement(1906950..1908188) 1 NC_003116.1 NMA1970, mtrC, membrane fusion protein, len: 412aa; strongly similar to many eg. SW:P43505 (MTRC_NEIGO) mtrC,membrane fusion protein from Neisseria gonorrhoeae (412 aa) fasta scores; E(): 0, 96.4% identity in 412 aa overlap and SW:P31223 (ACRA_ECOLI) acriflavin resistance protein from Escherichia coli (397 aa) fasta scores; E(): 0, 42.4% identity in 389 aa overlap. Contains Pfam match to entry PF00529 HlyD, HlyD family secretion protein and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and coiled-coil region.; membrane fusion protein 1908188 907467 NMA1970 Neisseria meningitidis Z2491 membrane fusion protein YP_002343242.1 1906950 R 122587 CDS YP_002343243.1 218768731 907469 1908596..1909228 1 NC_003116.1 NMA1971, mtrR, transcriptional regulator, len: 210aa; similar to many eg. SW:P39897 (MTRR_NEIGO) mtrR,transcriptional regulator from Neisseria gonorrhoeae (210 aa) fasta scores; E(): 0, 96.2% identity in 210 aa overlap. Contains Pfam match to entry PF00440 tetR,Bacterial regulatory proteins, tetR family; Prosite match to PS01081 Bacterial regulatory proteins, tetR family signature and helix-turn-helix 32-53aa (+6.17 SD).; transcriptional regulator 1909228 907469 NMA1971 Neisseria meningitidis Z2491 transcriptional regulator YP_002343243.1 1908596 D 122587 CDS YP_002343244.1 218768732 907466 complement(1909507..1909764) 1 NC_003116.1 NMA1972, unknown, len: 85aa; hypothetical protein 1909764 907466 NMA1972 Neisseria meningitidis Z2491 hypothetical protein YP_002343244.1 1909507 R 122587 CDS YP_002343245.1 218768733 907463 1910053..1911621 1 NC_003116.1 NMA1973, hypothetical integral membrane protein,len: 522aa; similar to SW:P46133 (YDAH_ECOLI) hypothetical protein from Escherichia coli (510 aa) fasta scores; E(): 0, 38.5% identity in 520 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1911621 907463 NMA1973 Neisseria meningitidis Z2491 hypothetical protein YP_002343245.1 1910053 D 122587 CDS YP_002343246.1 218768734 907464 complement(1911691..1914900) 1 NC_003116.1 NMA1974, recC, exodeoxyribonuclease V, len: 1069aa; similar to SW:P07648 (EX5C_ECOLI) recC,exodeoxyribonuclease V from Escherichia coli (1122 aa) fasta scores; E(): 0, 32.3% identity in 1110 aa overlap.; exodeoxyribonuclease V 1914900 907464 NMA1974 Neisseria meningitidis Z2491 exodeoxyribonuclease V YP_002343246.1 1911691 R 122587 CDS YP_002343247.1 218768735 907460 complement(1915001..1916410) 1 NC_003116.1 NMA1975, integral membrane protein, len: 469aa; contains membrane-spanning hydrophobic regions. Similar to TR:P72122 (EMBL:D28119) outer membrane protein from Pseudomonas aeruginosa (471 aa) fasta scores; E(): 0, 35.8% identity in 480 aa overlap.; integral membrane protein 1916410 907460 NMA1975 Neisseria meningitidis Z2491 integral membrane protein YP_002343247.1 1915001 R 122587 CDS YP_002343248.1 218768736 907447 complement(1918142..1918753) 1 NC_003116.1 CcoO; FixO; cbb3-type cytochrome c oxidase subunit II 1918753 907447 NMA1979 Neisseria meningitidis Z2491 cbb3-type cytochrome c oxidase subunit II YP_002343248.1 1918142 R 122587 CDS YP_002343249.1 218768737 907454 complement(1918780..1920225) 1 NC_003116.1 CcoN; FixN; cbb3-type cytochrome c oxidase subunit I 1920225 907454 NMA1980 Neisseria meningitidis Z2491 cbb3-type cytochrome c oxidase subunit I YP_002343249.1 1918780 R 122587 CDS YP_002343250.1 218768738 907449 1920531..1922288 1 NC_003116.1 NMA1981, hypothetical protein, len: 585aa; similar to TR:Q55449 (EMBL:D64006) hypothetical protein from Synechocystis sp. (strain PCC 6803) (584 aa) fasta scores; E(): 0, 34.3% identity in 589 aa overlap.; hypothetical protein 1922288 907449 NMA1981 Neisseria meningitidis Z2491 hypothetical protein YP_002343250.1 1920531 D 122587 CDS YP_002343251.1 218768739 907453 1922314..1922781 1 NC_003116.1 NMA1982, hypothetical protein, len: 155aa; similar to TR:O33514 (EMBL:U23145) hypothetical protein from Rhodobacter capsulatus (146 aa) fasta scores; E(): 5.7e-11, 34.6% identity in 130 aa overlap.; hypothetical protein 1922781 907453 NMA1982 Neisseria meningitidis Z2491 hypothetical protein YP_002343251.1 1922314 D 122587 CDS YP_002343252.1 218768740 907458 complement(1923468..1923902) 1 NC_003116.1 NMA1983, exbD, biopolymer transport protein, len: 144aa; previously sequenced therefore identical to SW:P95376 (EXBD_NEIME) exbD, biopolymer transport protein from Neisseria meningitidis (144 aa) fasta scores; E(): 0,100.0% identity in 144 aa overlap. Contains membrane-spanning and coiled-coil regions.; biopolymer transport protein 1923902 907458 NMA1983 Neisseria meningitidis Z2491 biopolymer transport protein YP_002343252.1 1923468 R 122587 CDS YP_002343253.1 218768741 907459 complement(1923905..1924567) 1 NC_003116.1 NMA1984, exbB, biopolymer transport protein, len: 220aa; almost identical to SW:P95375 (EXBB_NEIME) exbB,biopolymer transport protein from Neisseria meningitidis (220 aa) fasta scores; E(): 0, 98.6% identity in 220 aa overlap. Contains Pfam match to entry PF01618 MotA_ExbB and membrane-spanning hydrophobic regions.; biopolymer transport protein 1924567 907459 NMA1984 Neisseria meningitidis Z2491 biopolymer transport protein YP_002343253.1 1923905 R 122587 CDS YP_002343254.1 218768742 907455 complement(1924633..1925475) 1 NC_003116.1 NMA1985, tonB, TonB protein, len: 280aa; almost identical to SW:P95374 (TONB_NEIME) TonB protein from Neisseria meningitidis (278 aa) fasta scores; E(): 0,79.7% identity in 281 aa overlap.; TonB protein 1925475 907455 NMA1985 Neisseria meningitidis Z2491 TonB protein YP_002343254.1 1924633 R 122587 CDS YP_002343255.1 218768743 907452 1925730..1926368 1 NC_003116.1 NMA1986, conserved hypothetical integral membrane protein, len: 212aa; similar to many eg. TR:O67705 (EMBL:AE000759) hypothetical protein from Aquifex aeolicus (217 aa) fasta scores; E(): 2.1e-15, 41.2% identity in 199 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1926368 907452 NMA1986 Neisseria meningitidis Z2491 hypothetical protein YP_002343255.1 1925730 D 122587 CDS YP_002343256.1 218768744 907451 complement(1926820..1927620) 1 NC_003116.1 NMA1988, integral membrane protein, len: 266aa; contains membrane-spanning hydrophobic regions.; integral membrane protein 1927620 907451 NMA1988 Neisseria meningitidis Z2491 integral membrane protein YP_002343256.1 1926820 R 122587 CDS YP_002343257.1 218768745 907448 complement(1927756..1928274) 1 NC_003116.1 NMA1989, hypothetical integral membrane protein,len: 172aa; similar to two others in this strain: NMA0784 fasta scores; E(): 0, 82.7% identity in 173 aa overlap and NMA0786 fasta scores; E(): 47.6% identity in 168 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1928274 907448 NMA1989 Neisseria meningitidis Z2491 hypothetical protein YP_002343257.1 1927756 R 122587 CDS YP_002343258.1 218768746 907450 complement(1928596..1929237) 1 NC_003116.1 cofactor involved in the reduction of disulfides; glutaredoxin 1929237 grxB 907450 grxB Neisseria meningitidis Z2491 glutaredoxin YP_002343258.1 1928596 R 122587 CDS YP_002343259.1 218768747 907446 1929458..1931767 1 NC_003116.1 NMA1991, relA, GTP pyrophosphokinase, len: 769aa; similar to many eg. SW:P11585 (RELA_ECOLI) relA, GTP pyrophosphokinase from Escherichia coli (744 aa) fasta scores; E(): 0, 41.8% identity in 692 aa overlap.; GTP pyrophosphokinase 1931767 907446 NMA1991 Neisseria meningitidis Z2491 GTP pyrophosphokinase YP_002343259.1 1929458 D 122587 CDS YP_002343260.1 218768748 907445 complement(1933011..1934414) 1 NC_003116.1 NMA1994, natC, periplasmic type I secretion system protein, len: 467aa; previously sequenced in Neisseria meningitidis therefore almost identical to TR:AAD30978 (EMBL:AF121772) (467 aa) fasta scores; E(): 0,99.8% identity in 467 aa overlap. Also similar to many others eg. SW:P02930 (TOLC_ECOLI) TolC, type I secretion system protein from Escherichia coli (495 aa) fasta scores; E(): 8.8e-23, 27.6% identity in 439 aa overlap. Contains a coiled-ciol region.; periplasmic type I secretion system protein 1934414 907445 NMA1994 Neisseria meningitidis Z2491 periplasmic type I secretion system protein YP_002343260.1 1933011 R 122587 CDS YP_002343261.1 218768749 907440 complement(1934680..1936044) 1 NC_003116.1 NMA1996, natD', periplasmic type I secretion system protein, N-terminal region, len: 454aa; previously sequenced in Neisseria meningitidis therefore almost identical to N-terminal region of TR:AAD30977 (EMBL:AF121772) (475 aa) fasta scores; E(): 0, 98.9% identity in 439 aa overlap. Also similar to N-terminal region of SW:P09986 (HLY4_ECOLI) haemolysin secretion protein D from Escherichia coli (478 aa) fasta scores; E(): 0, 38.2% identity in 432 aa overlap. Note CDS is incomplete and may be able to frameshift into the downstream CDS due to the presence of a large tandem repeat between these two CDSs.; periplasmic type I secretion system protein 1936044 907440 NMA1996 Neisseria meningitidis Z2491 periplasmic type I secretion system protein YP_002343261.1 1934680 R 122587 CDS YP_002343262.1 218768750 907444 1937519..1938553 1 NC_003116.1 NMA1999, phage protein, len: 344 aa; shows weak similarity to e.g. TR:O34630 (EMBL:U83796), rstA2,Vibrio cholerae bacteriophage CTXphi protein required for replication and integration (359 aa), fasta scores; E(): 1.5e-09, 27.8% identity in 223 aa overlap. Also similar to TR:O82959 (EMBL:AB015669) ORF C7 from Burkholderia solanacearum plasmid pJTPS1 (444 aa), fasta scores; E(): 1.4e-16, 33.9% identity in 239 aa overlap. Highly similar to others from Neisseria meningitidis e.g. NMA1167, E(): 0, 100.0% identity in 344 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1938553 907444 NMA1999 Neisseria meningitidis Z2491 hypothetical protein YP_002343262.1 1937519 D 122587 CDS YP_002343263.1 218768751 907442 1938544..1938888 1 NC_003116.1 NMA2000, len: 114 aa; unknown, similar to others from Neisseria meningitidis e.g. NMA1168, fasta scores; E(): 0, 100.0% identity in 114 aa overlap; hypothetical protein 1938888 907442 NMA2000 Neisseria meningitidis Z2491 hypothetical protein YP_002343263.1 1938544 D 122587 CDS YP_002343264.1 218768752 907439 1938893..1939090 1 NC_003116.1 NMA2001, len: 65 aa; unknown, similar to others from Neisseria meningitidis e.g. NMA1169, fasta scores; E(): 4.2e-27, 100.0% identity in 65 aa overlap; hypothetical protein 1939090 907439 NMA2001 Neisseria meningitidis Z2491 hypothetical protein YP_002343264.1 1938893 D 122587 CDS YP_002343265.1 218768753 907438 1939098..1939382 1 NC_003116.1 NMA2002, len: 94 aa; unknown, similar to others from Neisseria meningitidis e.g. NMA1170, fasta scores; E(): 0, 100.0% identity in 94 aa overlap; hypothetical protein 1939382 907438 NMA2002 Neisseria meningitidis Z2491 hypothetical protein YP_002343265.1 1939098 D 122587 CDS YP_002343266.1 218768754 907437 1939389..1939667 1 NC_003116.1 NMA2003, len: 92 aa; unknown, similar to others from Neisseria meningitidis e.g. NMA2003, fasta scores; E(): 0, 100.0% identity in 92 aa overlap; hypothetical protein 1939667 907437 NMA2003 Neisseria meningitidis Z2491 hypothetical protein YP_002343266.1 1939389 D 122587 CDS YP_002343267.1 218768755 907436 1939780..1940112 1 NC_003116.1 NMA2004, len: 105 aa; similar to others from Neisseria meningitidis e.g. TR:O87782 (EMBL:AJ010115) Neisseria meningitidis strain B:15:P1.16 hypothetical protein (fragment) (148 aa), fasta scores; E(): 1.2e-24,57.3% identity in 110 aa overlap. Also similar to NMA1172,fasta scores; E(): 4e-25 54.8% identity in 104 aa overlap. Lies within a region of unusually low GC content.; hypothetical protein 1940112 907436 NMA2004 Neisseria meningitidis Z2491 hypothetical protein YP_002343267.1 1939780 D 122587 CDS YP_002343268.1 218768756 907435 1940096..1940491 1 NC_003116.1 NMA2005, probable cell-surface protein, len: 146 aa; highly similar to the N-terminus of TR:O87783 (EMBL:AJ010115), tspB, Neisseria meningitidis strain B:15:P1.16 T-cell and B-cell antigen (partial CDS) (504 aa), fasta scores; E(): 7.3e-25, 84.1% identity in 88 aa overlap. Similar to others from Neisseria meningitidis,e.g. NMA0776, fasta scores; E(): 1.9e-20, 61.5% identity in 96 aa overlap, and NMA1797 fasta scores; E(): 7.8e-23,68.0% identity in 97 aa overlap, (both tspB genes) and NMA1173 fasta scores; E(): 2.9e-30, 66.2% identity in 133 aa overlap (another cell-surface protein). N-terminal half has low GC content. Contains a probable N-terminal signal sequence; cell-surface protein 1940491 907435 NMA2005 Neisseria meningitidis Z2491 cell-surface protein YP_002343268.1 1940096 D 122587 CDS YP_002343269.1 218768757 907434 complement(1941209..1941568) 1 NC_003116.1 NMA2006, conserved hypothetical protein, len: 119aa; similar to many eg. TR:O67700 (EMBL:AE000759) hypothetical protein from Aquifex aeolicus (117 aa) fasta scores; E(): 3.6e-15, 42.0% identity in 112 aa overlap.; hypothetical protein 1941568 907434 NMA2006 Neisseria meningitidis Z2491 hypothetical protein YP_002343269.1 1941209 R 122587 CDS YP_002343270.1 218768758 907433 complement(1941591..1942235) 1 NC_003116.1 NMA2007, unknown, len: 214aa; hypothetical protein 1942235 907433 NMA2007 Neisseria meningitidis Z2491 hypothetical protein YP_002343270.1 1941591 R 122587 CDS YP_002343271.1 218768759 907432 complement(1942237..1942773) 1 NC_003116.1 NMA2008, conserved hypothetical protein, len: 178aa; similar to many eg. TR:O67698 (EMBL:AE000759) hypothetical protein from Aquifex aeolicus (186 aa) fasta scores; E(): 1.2e-16, 34.6% identity in 179 aa overlap.; hypothetical protein 1942773 907432 NMA2008 Neisseria meningitidis Z2491 hypothetical protein YP_002343271.1 1942237 R 122587 CDS YP_002343272.1 218768760 907431 complement(1942785..1943882) 1 NC_003116.1 NMA2009, unknown, len: 365aa; hypothetical protein 1943882 907431 NMA2009 Neisseria meningitidis Z2491 hypothetical protein YP_002343272.1 1942785 R 122587 CDS YP_002343273.1 218768761 907430 complement(1943885..1945276) 1 NC_003116.1 NMA2010, hypothetical protein, len: 463aa; weakly similar to TR:Q56292 (EMBL:L18975) hypothetical protein from Thiobacillus ferrooxidans (318 aa) fasta scores; E(): 0.86, 24.6% identity in 349 aa overlap.; hypothetical protein 1945276 907430 NMA2010 Neisseria meningitidis Z2491 hypothetical protein YP_002343273.1 1943885 R 122587 CDS YP_002343274.1 218768762 907429 complement(1945541..1946323) 1 NC_003116.1 NMA2011, conserved hypothetical protein, len: 264aa; highly similar to SW:P45249 (BIOC_HAEIN) biotin synthesis protein from Haemophilus influenzae (260 aa) fasta scores; E(): 0, 92.2% identity in 255 aa overlap. Also weakly similar to SW:P12999 (BIOC_ECOLI) biotin synthesis protein from Escherichia coli (251 aa) fasta scores; E(): 1.8e-07, 25.9% identity in 259 aa overlap.; hypothetical protein 1946323 907429 NMA2011 Neisseria meningitidis Z2491 hypothetical protein YP_002343274.1 1945541 R 122587 CDS YP_002343275.1 218768763 907428 complement(1946311..1946958) 1 NC_003116.1 NMA2012, conserved hypothetical protein, len: 215aa; highly similar to SW:P44251 (YF52_HAEIN) hypothetical protein from Haemophilus influenzae (215 aa) fasta scores; E(): 0, 86.0% identity in 215 aa overlap.; hypothetical protein 1946958 907428 NMA2012 Neisseria meningitidis Z2491 hypothetical protein YP_002343275.1 1946311 R 122587 CDS YP_002343276.1 218768764 907427 complement(1946968..1948110) 1 NC_003116.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1948110 bioF 907427 bioF Neisseria meningitidis Z2491 8-amino-7-oxononanoate synthase YP_002343276.1 1946968 R 122587 CDS YP_002343277.1 218768765 907426 1948333..1949409 1 NC_003116.1 NMA2014, unknown, len: 358aa; hypothetical protein 1949409 907426 NMA2014 Neisseria meningitidis Z2491 hypothetical protein YP_002343277.1 1948333 D 122587 CDS YP_002343278.1 218768766 907425 complement(1949616..1951082) 1 NC_003116.1 NMA2015, integral membrane transport protein, len: 488aa; similar to many eg. SW:Q41364 (SOT1_SPIOL) 2-oxoglutarate/malate translocator from Spinacia oleracea (Spinach) (569 aa) fasta scores; E(): 0,44.2% identity in 480 aa overlap. Contains Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region and several membrane-spanning hydrophobic regions.; integral membrane transport protein 1951082 907425 NMA2015 Neisseria meningitidis Z2491 integral membrane transport protein YP_002343278.1 1949616 R 122587 CDS YP_002343279.1 218768767 907424 complement(1951280..1952203) 1 NC_003116.1 catalyzes the formation of putrescine from agmatine; agmatinase 1952203 speB 907424 speB Neisseria meningitidis Z2491 agmatinase YP_002343279.1 1951280 R 122587 CDS YP_002343280.1 218768768 907423 complement(1952302..1954194) 1 NC_003116.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 1954194 speA 907423 speA Neisseria meningitidis Z2491 arginine decarboxylase YP_002343280.1 1952302 R 122587 CDS YP_002343281.1 218768769 907422 complement(1954361..1954645) 1 NC_003116.1 NMA2018, hypothetical periplasmic protein, len: 94aa; cContains a cleavable N-terminal signal sequence.; hypothetical periplasmic protein 1954645 907422 NMA2018 Neisseria meningitidis Z2491 hypothetical periplasmic protein YP_002343281.1 1954361 R 122587 CDS YP_002343282.1 218768770 907421 complement(1954796..1956604) 1 NC_003116.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1956604 aspS 907421 aspS Neisseria meningitidis Z2491 aspartyl-tRNA synthetase YP_002343282.1 1954796 R 122587 CDS YP_002343283.1 218768771 907420 complement(1956662..1957399) 1 NC_003116.1 NMA2020, integral membrane protein, len: 245aa; similar to TR:Q9Z846 (EMBL:AE001635) hypothetical protein from Chlamydia pneumoniae (223 aa) fasta scores; E(): 1.5e-21, 31.8% identity in 220 aa overlap. Contains membrane-spanning hydrophobic regions.; integral membrane protein 1957399 907420 NMA2020 Neisseria meningitidis Z2491 integral membrane protein YP_002343283.1 1956662 R 122587 CDS YP_002343284.1 218768772 907419 complement(1957506..1958735) 1 NC_003116.1 NMA2021, phopholipase, len: 409aa; similar to, but longer than, many eg. SW:P00631 (PA1_ECOLI) phopholipase A1 from Escherichia coli (289 aa) fasta scores; E(): 1.3e-25, 37.5% identity in 256 aa overlap. Note alternative translational start sites downstream.; phopholipase 1958735 907419 NMA2021 Neisseria meningitidis Z2491 phopholipase YP_002343284.1 1957506 R 122587 CDS YP_002343285.1 218768773 907418 complement(1958814..1959077) 1 NC_003116.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1959077 rpsT 907418 rpsT Neisseria meningitidis Z2491 30S ribosomal protein S20 YP_002343285.1 1958814 R 122587 CDS YP_002343286.1 218768774 907417 1959380..1960522 1 NC_003116.1 NMA2023, polyamine permease substrate-binding protein, len: 407aa; similar to many eg. SW:P31133 (POTF_ECOLI) putrescine-binding periplasmic protein (370 aa) fasta scores; E(): 0, 38.9% identity in 352 aa overlap. Also similar to NMA0831 (fasta scores; E(): 0, 54.8% identity in 396 aa overlap) and NMA2023 fasta scores; (E(): 0, 55.2% identity in 377 aa overlap) from Neisseria meningitidis. Contains a cleavable N-terminal signal sequence.; polyamine permease substrate-binding protein 1960522 907417 NMA2023 Neisseria meningitidis Z2491 polyamine permease substrate-binding protein YP_002343286.1 1959380 D 122587 CDS YP_002343287.1 218768775 907416 complement(1962649..1965381) 1 NC_003116.1 NMA2024, tbpA, transferrin-binding protein A, len: 910aa; previously sequenced therefore identical to TR:Q53348 (EMBL:AF058689). Contains Pfam match to entry PF00593 TonB_boxC, TonB dependent receptor C-terminal region and Prosite match to PS01156 TonB-dependent receptor proteins signature 2.; transferrin-binding protein A 1965381 907416 NMA2024 Neisseria meningitidis Z2491 transferrin-binding protein A YP_002343287.1 1962649 R 122587 CDS YP_002343288.1 218768776 907415 complement(1965468..1967564) 1 NC_003116.1 NMA2025, tbpB, transferrin-binding protein B, len: 698aa; previously sequenced therefore identical to TR:O68937 (EMBL:AF058689). Contains Pfam match to entry PF01298 Lipoprotein_5, Transferrin binding protein and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; transferrin-binding protein B 1967564 907415 NMA2025 Neisseria meningitidis Z2491 transferrin-binding protein B YP_002343288.1 1965468 R 122587 CDS YP_002343289.1 218768777 907414 complement(1969683..1970495) 1 NC_003116.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1970495 glr 907414 glr Neisseria meningitidis Z2491 glutamate racemase YP_002343289.1 1969683 R 122587 CDS YP_002343290.1 218768778 907413 1970697..1971158 1 NC_003116.1 NMA2027, conserved hypothetical protein, len: 153aa; similar to many eg. SW:P31805 (YJEE_ECOLI) hypothetical protein from Escherichia coli (153 aa) fasta scores; E(): 9.3e-26, 48.9% identity in 137 aa overlap.; hypothetical protein 1971158 907413 NMA2027 Neisseria meningitidis Z2491 hypothetical protein YP_002343290.1 1970697 D 122587 CDS YP_002343291.1 218768779 907412 1971155..1972405 1 NC_003116.1 NMA2028, amiC, N-acetylmuramoyl-L-alanine amidase,len: 416aa; similar to many eg. SW:Q46929 (AMIC_ECOLI) amiC, N-acetylmuramoyl-L-alanine amidase from Escherichia coli (417 aa) fasta scores; E(): 0, 51.1% identity in 425 aa overlap. Contains Pfam match to entry PF01520 Amidase_3.; N-acetylmuramoyl-L-alanine amidase 1972405 907412 NMA2028 Neisseria meningitidis Z2491 N-acetylmuramoyl-L-alanine amidase YP_002343291.1 1971155 D 122587 CDS YP_002343292.1 218768780 907411 1972431..1973303 1 NC_003116.1 NMA2029, unknown, len: 290aa; hypothetical protein 1973303 907411 NMA2029 Neisseria meningitidis Z2491 hypothetical protein YP_002343292.1 1972431 D 122587 CDS YP_002343293.1 218768781 907410 complement(1973599..1974741) 1 NC_003116.1 NMA2030, conserved hypothetical protein, len: 380aa; similar to the N-terminal half of many hypothetical proteins eg. SW:P75864 (YCBY_ECOLI) hypothetical protein from Escherichia coli (702 aa) fasta scores; E(): 0, 37.9% identity in 372 aa overlap. Also similar and equal in length to many others eg. SW:Q55156 (Y064_SYNY3) hypothetical protein from Synechocystis sp. (strain PCC 6803) (384 aa) fasta scores; E(): 0, 34.8% identity in 374 aa overlap. Contains Pfam match to entry PF01170 UPF0020,Uncharacterized protein family UPF0020 and Prosite match to PS01261 Uncharacterized protein family UPF0020 signature.; hypothetical protein 1974741 907410 NMA2030 Neisseria meningitidis Z2491 hypothetical protein YP_002343293.1 1973599 R 122587 CDS YP_002343294.1 218768782 907409 complement(1974790..1975212) 1 NC_003116.1 NMA2031, secreted protein, len: 140aa; contains a cleavable N-terminal signal sequence.; secreted protein 1975212 907409 NMA2031 Neisseria meningitidis Z2491 secreted protein YP_002343294.1 1974790 R 122587 CDS YP_002343295.1 218768783 907408 complement(1975205..1976014) 1 NC_003116.1 NMA2032, MutT-related protein, len: 269aa; similar to but larger than many MutT homlogs eg. SW:P44932 (MUTT_HAEIN) MutT protein from Haemophilus influenzae (136 aa) fasta scores; E(): 3.5e-13, 40.6% identity in 128 aa overlap. Contains Pfam match to entry PF00293 mutT,Bacterial mutT protein and Prosite match to PS00893 mutT domain signature.; MutT-like protein 1976014 907408 NMA2032 Neisseria meningitidis Z2491 MutT-like protein YP_002343295.1 1975205 R 122587 CDS YP_002343296.1 218768784 907407 complement(1976091..1976468) 1 NC_003116.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1976468 acpS 907407 acpS Neisseria meningitidis Z2491 4'-phosphopantetheinyl transferase YP_002343296.1 1976091 R 122587 CDS YP_002343297.1 218768785 907405 complement(1976669..1977436) 1 NC_003116.1 NMA2035, conserved hypothetical protein, len: 255aa; weakly similar to many eg. TR:O66527 (EMBL:AE000675) hypothetical protein from Aquifex aeolicus (272 aa) fasta scores; E(): 0.0001, 24.6% identity in 256 aa overlap. Lies in a region of unusually low GC content.; hypothetical protein 1977436 907405 NMA2035 Neisseria meningitidis Z2491 hypothetical protein YP_002343297.1 1976669 R 122587 CDS YP_002343298.1 218768786 907404 complement(1977446..1978225) 1 NC_003116.1 NMA2036, unknown, len: 259aa; Lies in a region of unusually low GC content.; hypothetical protein 1978225 907404 NMA2036 Neisseria meningitidis Z2491 hypothetical protein YP_002343298.1 1977446 R 122587 CDS YP_002343299.1 218768787 907403 complement(1978272..1979000) 1 NC_003116.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 1979000 pdxJ 907403 pdxJ Neisseria meningitidis Z2491 pyridoxine 5'-phosphate synthase YP_002343299.1 1978272 R 122587 CDS YP_002343300.1 218768788 907402 complement(1979024..1979818) 1 NC_003116.1 NMA2038, recO, DNA repair protein (recombination protein o), len: aa; similar to many eg. TR:Q9ZHY2 (EMBL:AF047375) RecO protein from Neisseria gonorrhoeae (247 aa) fasta scores; E(): 0, 80.7% identity in 244 aa overlap.; DNA repair protein (recombination protein o) 1979818 907402 NMA2038 Neisseria meningitidis Z2491 DNA repair protein (recombination protein o) YP_002343300.1 1979024 R 122587 CDS YP_002343301.1 218768789 907401 complement(1979849..1980976) 1 NC_003116.1 NMA2039, pheA, chorismate mutase, len: 375aa; similar to many egs. TR:Q9ZHY3 (EMBL:AF047375) PheA from Neisseria gonorrhoeae (375 aa) fasta scores; E(): 0, 98.7% identity in 375 aa overlap and SW:P27603 (PHEA_PSEST) chorismate mutase from Pseudomonas stutzeri (365 aa) fasta scores; E(): 0, 50.4% identity in 357 aa overlap. Contains Pfam match to entry PF00800 PDT, Prephenate dehydratase and Prosite match to PS00857 Prephenate dehydratase signature 1.; chorismate mutase 1980976 907401 NMA2039 Neisseria meningitidis Z2491 chorismate mutase YP_002343301.1 1979849 R 122587 CDS YP_002343302.1 218768790 907400 complement(1981015..1982247) 1 NC_003116.1 NMA2040, integral membrane efflux protein,len: 410aa; similar to many eg. SW:P28246 (BCR_ECOLI) bicyclomycin resistance protein from Escherichia coli (396 aa) fasta scores; E(): 0, 29.0% identity in 386 aa overlap. Contains membrane-spanning hydrophobic regions.; integral membrane efflux protein 1982247 907400 NMA2040 Neisseria meningitidis Z2491 integral membrane efflux protein YP_002343302.1 1981015 R 122587 CDS YP_002343303.1 218768791 907399 complement(1982766..1983620) 1 NC_003116.1 NMA2041, conserved hypothetical protein, len: 284aa; similar to many hypothetical protein, some of which occur as two seperate CDSs ie. N-terminal region similar to SW:Q57147 (Y976_HAEIN) hypothetical protein from Haemophilus influenzae (128 aa) fasta scores; E(): 1.1e-18, 53.5% identity in 114 aa overlap; C-terminal region similar to SW:O86230 (Y97X_HAEIN) hypothetical protein from Haemophilus influenzae (170 aa) fasta scores; E(): 8.9e-27, 48.1% identity in 156 aa overlap. Contains a Pfam match to entry PF00892 DUF6, Integral membrane protein in both the N and C-terminal regions.; hypothetical protein 1983620 907399 NMA2041 Neisseria meningitidis Z2491 hypothetical protein YP_002343303.1 1982766 R 122587 CDS YP_002343304.1 218768792 907397 complement(1987822..1988634) 1 NC_003116.1 NMA2044, conserved hypothetical protein, len: 270aa; similar to SW:P55175 (Y601_SYNY3) hypothetical protein from Synechocystis sp. (strain PCC 6803) (272 aa) fasta scores; E(): 0, 40.4% identity in 275 aa overlap.; hypothetical protein 1988634 907397 NMA2044 Neisseria meningitidis Z2491 hypothetical protein YP_002343304.1 1987822 R 122587 CDS YP_002343305.1 218768793 907396 1988719..1989591 1 NC_003116.1 NMA2045, oxidoreductase, len: 290aa; similar to many eg. SW:P20692 (TYRA_BACSU) prephenate dehydrogenase from Bacillus subtilis (372 aa) fasta scores; E(): 2.8e-30, 39.4% identity in 284 aa overlap.; oxidoreductase 1989591 907396 NMA2045 Neisseria meningitidis Z2491 oxidoreductase YP_002343305.1 1988719 D 122587 CDS YP_002343306.1 218768794 907395 complement(1989648..1990850) 1 NC_003116.1 NMA2046, hypothetical integral membrane protein,len: 400aa; similar to TR:P95556 (EMBL:Z73914) hypothetical protein from Pseudomonas stutzeri (396 aa) fasta scores; E(): 0, 35.0% identity in 391 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1990850 907395 NMA2046 Neisseria meningitidis Z2491 hypothetical protein YP_002343306.1 1989648 R 122587 CDS YP_002343307.1 218768795 907394 complement(1990847..1991215) 1 NC_003116.1 NMA2047, hypothetical protein, len: 122aa; weakly similar to SW:P71932 (YQ03_MYCTU) hypothetical protein from Mycobacterium tuberculosis (161 aa) fasta scores; E(): 0.017, 32.5% identity in 117 aa overlap.; hypothetical protein 1991215 907394 NMA2047 Neisseria meningitidis Z2491 hypothetical protein YP_002343307.1 1990847 R 122587 CDS YP_002343308.1 218768796 907393 1991389..1991832 1 NC_003116.1 NMA2048, conserved hypothetical protein, len: 147aa; similar to many eg. SW:P21498 (YJEB_ECOLI) hypothetical protein from Escherichia coli (141 aa) fasta scores; E(): 5.9e-23, 47.9% identity in 140 aa overlap.; hypothetical protein 1991832 907393 NMA2048 Neisseria meningitidis Z2491 hypothetical protein YP_002343308.1 1991389 D 122587 CDS YP_002343309.1 218768797 907392 complement(1991959..1992579) 1 NC_003116.1 NMA2049, conserved hypothetical protein, len: 206aa; similar to many eg. SW:P45847 (YCIO_ECOLI) hypothetical protein from Escherichia coli (206 aa) fasta scores; E(): 0, 62.9% identity in 205 aa overlap. Contains Pfam match to entry PF01300 Sua5_yciO_yrdC, SUA5/yciO/yrdC family and Prosite match to PS01147 SUA5/yciO/yrdC family signature.; hypothetical protein 1992579 907392 NMA2049 Neisseria meningitidis Z2491 hypothetical protein YP_002343309.1 1991959 R 122587 CDS YP_002343310.1 218768798 907391 complement(1992937..1994136) 1 NC_003116.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1994136 ackA2 907391 ackA2 Neisseria meningitidis Z2491 acetate kinase YP_002343310.1 1992937 R 122587 CDS YP_002343311.1 218768799 907390 complement(1994550..1995719) 1 NC_003116.1 NMA2051, conserved hypothetical protein, len: 389aa; similar to SW:O07931 (YRAM_BACSU) hypothetical protein from Bacillus subtilis (367 aa) fasta scores; E(): 0, 37.1% identity in 385 aa overlap.; hypothetical protein 1995719 907390 NMA2051 Neisseria meningitidis Z2491 hypothetical protein YP_002343311.1 1994550 R 122587 CDS YP_002343312.1 218768800 907389 complement(1996523..1999129) 1 NC_003116.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1999129 acnA 907389 acnA Neisseria meningitidis Z2491 aconitate hydratase YP_002343312.1 1996523 R 122587 CDS YP_002343313.1 218768801 907388 complement(1999207..1999995) 1 NC_003116.1 NMA2053, conserved hypothetical integral membrane protein, len: 262aa; similar to many eg. SW:P29942 (YCB9_PSEDE) hypothetical protein from Pseudomonas denitrificans (261 aa) fasta scores; E(): 0, 48.4% identity in 256 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1999995 907388 NMA2053 Neisseria meningitidis Z2491 hypothetical protein YP_002343313.1 1999207 R 122587 CDS YP_002343314.1 218768802 907387 complement(2000156..2001310) 1 NC_003116.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 2001310 prpC 907387 prpC Neisseria meningitidis Z2491 methylcitrate synthase YP_002343314.1 2000156 R 122587 CDS YP_002343315.1 218768803 907386 complement(2001396..2002274) 1 NC_003116.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 2002274 prpB 907386 prpB Neisseria meningitidis Z2491 2-methylisocitrate lyase YP_002343315.1 2001396 R 122587 CDS YP_002343316.1 218768804 907385 complement(2002897..2004207) 1 NC_003116.1 NMA2056, conserved hypothetical protein, len: 436aa; similar to many eg. SW:Q57772 (Y326_METJA) hypothetical protein from Methanococcus jannaschii (436 aa) fasta scores; E(): 0, 50.5% identity in 430 aa overlap. Contains Pfam match to entry PF00860 xan_ur_permease, Xanthine/uracil permeases family.; hypothetical protein 2004207 907385 NMA2056 Neisseria meningitidis Z2491 hypothetical protein YP_002343316.1 2002897 R 122587 CDS YP_002343317.1 218768805 907384 complement(2004346..2005524) 1 NC_003116.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 2005524 ftsZ 907384 ftsZ Neisseria meningitidis Z2491 cell division protein FtsZ YP_002343317.1 2004346 R 122587 CDS YP_002343318.1 218768806 907383 complement(2005643..2006887) 1 NC_003116.1 NMA2058, ftsA, cell division protein, len: 414aa; strongly similar to many eg. SW:P06137 (FTSA_ECOLI) ftsA,cell division protein from Escherichia coli (420 aa) fasta scores; E(): 0, 41.9% identity in 420 aa overlap.; cell division protein 2006887 907383 NMA2058 Neisseria meningitidis Z2491 cell division protein YP_002343318.1 2005643 R 122587 CDS YP_002343319.1 218768807 907382 complement(2006973..2007701) 1 NC_003116.1 NMA2059, ftsQ, cell division protein, len: 242aa; similar to many eg. SW:P06136 (FTSQ_ECOLI) ftsQ, cell division protein from Escherichia coli (276 aa) fasta scores; E(): 9.1e-26, 34.7% identity in 239 aa overlap.; cell division protein 2007701 907382 NMA2059 Neisseria meningitidis Z2491 cell division protein YP_002343319.1 2006973 R 122587 CDS YP_002343320.1 218768808 907381 complement(2007691..2008605) 1 NC_003116.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 2008605 ddl 907381 ddl Neisseria meningitidis Z2491 D-alanine--D-alanine ligase YP_002343320.1 2007691 R 122587 CDS YP_002343321.1 218768809 907380 complement(2008718..2010124) 1 NC_003116.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 2010124 murC 907380 murC Neisseria meningitidis Z2491 UDP-N-acetylmuramate--L-alanine ligase YP_002343321.1 2008718 R 122587 CDS YP_002343322.1 218768810 907379 complement(2010282..2011349) 1 NC_003116.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 2011349 murG 907379 murG Neisseria meningitidis Z2491 UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_002343322.1 2010282 R 122587 CDS YP_002343323.1 218768811 907378 complement(2011353..2012660) 1 NC_003116.1 NMA2063, ftsW, cell division protein, len: 435aa; similar to many eg. SW:P16457 (FTSW_ECOLI) ftsW, cell division protein from Escherichia coli (414 aa) fasta scores; E(): 0, 39.3% identity in 394 aa overlap. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein and Prosite match to PS00428 Cell cycle proteins ftsW / rodA / spoVE signature.; cell division protein 2012660 907378 NMA2063 Neisseria meningitidis Z2491 cell division protein YP_002343323.1 2011353 R 122587 CDS YP_002343324.1 218768812 907377 complement(2012804..2014141) 1 NC_003116.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 2014141 murD 907377 murD Neisseria meningitidis Z2491 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002343324.1 2012804 R 122587 CDS YP_002343325.1 218768813 907376 complement(2014226..2014498) 1 NC_003116.1 NMA2065, periplasmic protein, len: 90aa; contains a cleavable N-terminal signal sequence.; hypothetical protein 2014498 907376 NMA2065 Neisseria meningitidis Z2491 hypothetical protein YP_002343325.1 2014226 R 122587 CDS YP_002343326.1 218768814 907375 complement(2014613..2015695) 1 NC_003116.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 2015695 mraY 907375 mraY Neisseria meningitidis Z2491 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002343326.1 2014613 R 122587 CDS YP_002343327.1 218768815 907374 complement(2015789..2015971) 1 NC_003116.1 NMA2067, periplasmic protein, len: 60aa; contains a cleavable N-terminal signal sequence.; hypothetical protein 2015971 907374 NMA2067 Neisseria meningitidis Z2491 hypothetical protein YP_002343327.1 2015789 R 122587 CDS YP_002343328.1 218768816 907373 complement(2015968..2017326) 1 NC_003116.1 NMA2068, murF, UDP-MurNAc-pentapeptide synthetase,len: 452aa; similar to many eg. SW:P11880 (MURF_ECOLI) murF, UDP-MurNAc-pentapeptide synthetase from Escherichia coli (452 aa) fasta scores; E(): 0, 41.0% identity in 456 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family.; UDP-MurNAc-pentapeptide synthetase 2017326 907373 NMA2068 Neisseria meningitidis Z2491 UDP-MurNAc-pentapeptide synthetase YP_002343328.1 2015968 R 122587 CDS YP_002343329.1 218768817 907371 complement(2019121..2020599) 1 NC_003116.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 2020599 murE 907371 murE Neisseria meningitidis Z2491 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_002343329.1 2019121 R 122587 CDS YP_002343330.1 218768818 907370 complement(2020624..2022369) 1 NC_003116.1 NMA2072, penA, penicillin-binding protein 2, len: 581aa; highly similar to many from Neisseria. Identical to SW:P11882 (PBP2_NEIME) from Neisseria meningitidis (581 aa). Contains Pfam match to entry PF00905 Transpeptidase,Penicillin binding protein transpeptidase domain.; penicillin-binding protein 2 2022369 907370 NMA2072 Neisseria meningitidis Z2491 penicillin-binding protein 2 YP_002343330.1 2020624 R 122587 CDS YP_002343331.1 218768819 907369 complement(2022430..2022699) 1 NC_003116.1 NMA2073, small periplasmic protein, len: 89aa; contains a cleavable N-terminal signal sequence.; small periplasmic protein 2022699 907369 NMA2073 Neisseria meningitidis Z2491 small periplasmic protein YP_002343331.1 2022430 R 122587 CDS YP_002343332.1 218768820 907368 complement(2022690..2023676) 1 NC_003116.1 NMA2074, conserved hypothetical protein, len: aa; similar to many eg. SW:P18595 (YABC_ECOLI) hypothetical protein from Escherichia coli (313 aa) fasta scores; E(): 0, 53.3% identity in 315 aa overlap.; S-adenosyl-methyltransferase MraW 2023676 mraW 907368 mraW Neisseria meningitidis Z2491 S-adenosyl-methyltransferase MraW YP_002343332.1 2022690 R 122587 CDS YP_002343333.1 218768821 907367 complement(2023673..2024128) 1 NC_003116.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 2024128 907367 NMA2075 Neisseria meningitidis Z2491 cell division protein MraZ YP_002343333.1 2023673 R 122587 CDS YP_002343334.1 218768822 907366 2024407..2025624 1 NC_003116.1 NMA2076, conserved hypothetical protein, len: 405aa; similar to many eg. TR:Q57456 (EMBL:D64000) hypothetical protein from Synechocystis sp. (strain PCC 6803) (416 aa) fasta scores; E(): 0, 33.2% identity in 371 aa overlap. Note alternative downstream start codons.; hypothetical protein 2025624 907366 NMA2076 Neisseria meningitidis Z2491 hypothetical protein YP_002343334.1 2024407 D 122587 CDS YP_002343335.1 218768823 907365 complement(2026199..2027020) 1 NC_003116.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 2027020 907365 NMA2077 Neisseria meningitidis Z2491 UDP pyrophosphate phosphatase YP_002343335.1 2026199 R 122587 CDS YP_002343336.1 218768824 907364 complement(2027053..2027697) 1 NC_003116.1 NMA2078, thiol:disulphide interchange protein, len: 214aa; weakly similar to many eg. SW:P95460 (DSBA_PSEAE) DsbA, proposed thiol:disulphide interchange protein from Pseudomonas aeruginosa (210 aa) fasta scores; E(): 2.1e-16, 33.5% identity in 203 aa overlap. Contains Pfam match to entry PF01323 DSBA, DSBA oxidoreductase and Prosite match to PS00194 Thioredoxin family active site. Contains a cleavable N-terminal signal sequence.; thiol:disulfide interchange protein 2027697 907364 NMA2078 Neisseria meningitidis Z2491 thiol:disulfide interchange protein YP_002343336.1 2027053 R 122587 CDS YP_002343337.1 218768825 907363 complement(2027700..2028569) 1 NC_003116.1 NMA2079, hypothetical lysine-rich membrane protein,len: 289aa; contains a non-cleavable N-terminal signal sequence.; hypothetical protein 2028569 907363 NMA2079 Neisseria meningitidis Z2491 hypothetical protein YP_002343337.1 2027700 R 122587 CDS YP_002343338.1 218768826 907362 complement(2028669..2030165) 1 NC_003116.1 NMA2080, chelatase, len: 498aa; similar to many eg. SW:P45049 (YIFB_HAEIN) hypothetical protein from Haemophilus influenzae (509 aa) fasta scores; E(): 0,50.0% identity in 500 aa overlap. Contains Pfam match to entry PF01078 Mg_chelatase, Magnesium chelatase, subunit ChlI.; chelatase 2030165 907362 NMA2080 Neisseria meningitidis Z2491 chelatase YP_002343338.1 2028669 R 122587 CDS YP_002343339.1 218768827 907361 complement(2030179..2030532) 1 NC_003116.1 NMA2081, hypothetical protein, len: 117aa; N-terminal region similar to SW:Q46868 (YQIC_ECOLI) hypothetical protein from Escherichia coli (116 aa) fasta scores; E(): 2.7e-06, 40.7% identity in 81 aa overlap. Contains coiled-coil region.; hypothetical protein 2030532 907361 NMA2081 Neisseria meningitidis Z2491 hypothetical protein YP_002343339.1 2030179 R 122587 CDS YP_002343340.1 218768828 907360 2030982..2032508 1 NC_003116.1 NMA2083, putP, sodium/proline symporter, len: 508aa; strongly similar to many eg. SW:P07117 (PUTP_ECOLI) putP, sodium/proline symporter from Escherichia coli (502 aa) fasta scores; E(): 0, 64.1% identity in 504 aa overlap. Contains Pfam match to entry PF00474 SSF,Sodium:solute symporter family, Prosite match to PS00456 Sodium:solute symporter family signature 1 and Prosite match to PS00457 Sodium:solute symporter family signature 2.; sodium/proline symporter 2032508 907360 NMA2083 Neisseria meningitidis Z2491 sodium/proline symporter YP_002343340.1 2030982 D 122587 CDS YP_002343341.1 218768829 907359 2032759..2036364 1 NC_003116.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 2036364 putA 907359 putA Neisseria meningitidis Z2491 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_002343341.1 2032759 D 122587 CDS YP_002343342.1 218768830 907357 complement(2039124..2039894) 1 NC_003116.1 NMA2086, xthA, exodeoxyribonuclease III, len: 256aa; similar to many eg. SW:P09030 (EX3_ECOLI) xthA,exodeoxyribonuclease III from Escherichia coli (268 aa) fasta scores; E(): 1.6e-17, 36.5% identity in 266 aa overlap. Contains Pfam match to entry PF01260 AP_endonucleas1, AP endonuclease family 1 and Prosite match to PS00726 AP endonucleases family 1 signature 1.; exodeoxyribonuclease III 2039894 907357 NMA2086 Neisseria meningitidis Z2491 exodeoxyribonuclease III YP_002343342.1 2039124 R 122587 CDS YP_002343343.1 218768831 907355 complement(2040486..2041367) 1 NC_003116.1 NMA2088, nadC, nicotinate-nucleotide pyrophosphorylase, len: 293aa; similar to many eg. SW:O06594 (NADC_MYCTU) nadC, nicotinate-nucleotide pyrophosphorylase from Mycobacterium tuberculosis (285 aa) fasta scores; E(): 0, 45.5% identity in 277 aa overlap.; nicotinate-nucleotide pyrophosphorylase 2041367 907355 NMA2088 Neisseria meningitidis Z2491 nicotinate-nucleotide pyrophosphorylase YP_002343343.1 2040486 R 122587 CDS YP_002343344.1 218768832 907354 complement(2041596..2042534) 1 NC_003116.1 NMA2089, cytoplasmic membrane protein,len: 312aa; contains a non-cleavable N-terminal signal sequence. Region around 200-300aa similar to region in several hypothetical proteins eg. TR:P74291 (EMBL:D90913) from Synechocystis sp. strain PCC6803 (261 aa) fasta scores; E(): 1.7e-05, 27.1% identity in 129 aa overlap.; cytoplasmic membrane protein 2042534 907354 NMA2089 Neisseria meningitidis Z2491 cytoplasmic membrane protein YP_002343344.1 2041596 R 122587 CDS YP_002343345.1 218768833 907353 2042839..2043951 1 NC_003116.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 2043951 nadA 907353 nadA Neisseria meningitidis Z2491 quinolinate synthetase YP_002343345.1 2042839 D 122587 CDS YP_002343346.1 218768834 907352 2044102..2044437 1 NC_003116.1 NMA2091, integral membrane drug resistance protein, len: 111aa; strongly similar to many drug resistance proteins eg. SW:P14319 (EBR_STAAU) ethidium bromide resistance protein from Staphylococcus aureus (107 aa) fasta scores; E(): 2.5e-17, 53.5% identity in 101 aa overlap. Contains Pfam match to entry PF00893 DUF7,Integral membrane protein.; integral membrane drug resistance protein 2044437 907352 NMA2091 Neisseria meningitidis Z2491 integral membrane drug resistance protein YP_002343346.1 2044102 D 122587 CDS YP_002343347.1 218768835 907351 2044486..2045994 1 NC_003116.1 NMA2092, nadB, L-aspartate oxidase, len: 502aa; similar to many eg. SW:P38032 (NADB_BACSU) nadB,L-aspartate oxidase from Bacillus subtilis (531 aa) fasta scores; E(): 0, 37.3% identity in 507 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain.; L-aspartate oxidase 2045994 907351 NMA2092 Neisseria meningitidis Z2491 L-aspartate oxidase YP_002343347.1 2044486 D 122587 CDS YP_002343348.1 218768836 907350 complement(2046172..2046837) 1 NC_003116.1 NMA2093, pgm2, beta-phosphoglucomutase, len: 221aa; similar to many eg. SW:P71447 (PGMB_LACLA) pgmB,beta-phosphoglucomutase from Lactococcus lactis (subsp. lactis) (221 aa) fasta scores; E(): 0, 68.2% identity in 220 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. Highly similar to the neighbouring gene NMA2097 (fasta scores; E(): 0, 95.9% identity in 221 aa overlap) indicating a duplication event.; beta-phosphoglucomutase 2046837 907350 NMA2093 Neisseria meningitidis Z2491 beta-phosphoglucomutase YP_002343348.1 2046172 R 122587 CDS YP_002343349.1 218768837 907348 complement(2047183..2048235) 1 NC_003116.1 NMA2095, integral membrane efflux protein,len: 350aa; similar to SW:P74311 (Y944_SYNY3) hypothetical protein from Synechocystis sp. (strain PCC 6803) (383 aa) fasta scores; E(): 0, 44.4% identity in 342 aa overlap. Weakly similar to SW:Q06598 (ACR3_YEAST) arsenical resistance protein from Saccharomyces cerevisiae (Baker's yeast) (404 aa) fasta scores; E(): 2.2e-13, 26.4% identity in 382 aa overlap. Lies in a region of unusually low GC content and may therefore be 'recently acquired'. Contains membrane-spanning hydrophobic regions.; integral membrane efflux protein 2048235 907348 NMA2095 Neisseria meningitidis Z2491 integral membrane efflux protein YP_002343349.1 2047183 R 122587 CDS YP_002343350.1 218768838 907346 complement(2048792..2049457) 1 NC_003116.1 NMA2097, pgm1, beta-phosphoglucomutase, len: 221aa; similar to many eg. SW:P71447 (PGMB_LACLA) pgmB,beta-phosphoglucomutase from Lactococcus lactis (subsp. lactis) (221 aa) fasta scores; E(): 0, 66.4% identity in 220 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. Highly similar to the neighbouring gene NMA2093 (fasta scores; E(): 0, 95.9% identity in 221 aa overlap) indicating a duplication event.; beta-phosphoglucomutase 2049457 907346 NMA2097 Neisseria meningitidis Z2491 beta-phosphoglucomutase YP_002343350.1 2048792 R 122587 CDS YP_002343351.1 218768839 907345 complement(2049470..2051728) 1 NC_003116.1 NMA2098, mapA, maltose phosphorylase, len: 752aa; similar to TR:O87772 (EMBL:AJ224340) mapA, maltose phosphorylase from Lactobacillus sanfrancisco (753 aa) fasta scores; E(): 0, 59.9% identity in 749 aa overlap. C-terminus highly similar to the neighbouring gene NMA2094 (fasta scores; E(): 3.5e-32, 98.8% identity in 86 aa overlap) indicating a duplication event.; maltose phosphorylase 2051728 mapA 907345 mapA Neisseria meningitidis Z2491 maltose phosphorylase YP_002343351.1 2049470 R 122587 CDS YP_002343352.1 218768840 907344 complement(2051961..2052971) 1 NC_003116.1 NMA2099, galM, aldose 1-epimerase (mutarotase),len: 336aa; similar to many eg. SW:P21955 (GALM_STRTR) galM, aldose 1-epimerase (mutarotase) from Streptococcus thermophilus (348 aa) fasta scores; E(): 4e-22, 35.3% identity in 340 aa overlap. Contains Pfam match to entry PF01263 Aldose_epim, Aldose 1-epimerase.; aldose 1-epimerase 2052971 907344 NMA2099 Neisseria meningitidis Z2491 aldose 1-epimerase YP_002343352.1 2051961 R 122587 CDS YP_002343353.1 218768841 907343 complement(2052975..2054330) 1 NC_003116.1 NMA2100, integral membrane transport protein, len: 451aa; similar to many eg. SW:Q03411 (STP_SPIOL) sucrose transport protein from Spinacia oleracea (Spinach) (525 aa) fasta scores; E(): 6.5e-07,24.5% identity in 493 aa overlap.; integral membrane transport protein 2054330 907343 NMA2100 Neisseria meningitidis Z2491 integral membrane transport protein YP_002343353.1 2052975 R 122587 CDS YP_002343354.1 218768842 907342 2054717..2056393 1 NC_003116.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 2056393 907342 NMA2101 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002343354.1 2054717 D 122587 CDS YP_002343355.1 218768843 907341 complement(2056453..2056938) 1 NC_003116.1 NMA2102, pgpA, phosphatidylglycerophosphatase A,inner membrane, len: 161aa; similar to SW:P18200 (PGPA_ECOLI) pgpA, phosphatidylglycerophosphatase A from Escherichia coli (172 aa) fasta scores; E(): 6.7e-24,42.1% identity in 145 aa overlap. Contains membrane-spanning hydrophobic regions.; phosphatidylglycerophosphatase A 2056938 907341 NMA2102 Neisseria meningitidis Z2491 phosphatidylglycerophosphatase A YP_002343355.1 2056453 R 122587 CDS YP_002343356.1 218768844 907340 complement(2056931..2057887) 1 NC_003116.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 2057887 thiL 907340 thiL Neisseria meningitidis Z2491 thiamine monophosphate kinase YP_002343356.1 2056931 R 122587 CDS YP_002343357.1 218768845 907339 complement(2058708..2059436) 1 NC_003116.1 NMA2105, rmpM, outer membrane protein class 4, len: 242aa; strongly similar to SW:P38367 (OMP4_NEIME) rmpM,outer membrane protein class 4 from Neisseria meningitidis (240 aa) fasta scores; E(): 0, 99.2% identity in 242 aa overlap. Contains Pfam match to entry PF00691 OmpA, OmpA family and Prosite match to PS01068 OmpA-like domain.; outer membrane protein class 4 2059436 907339 NMA2105 Neisseria meningitidis Z2491 outer membrane protein class 4 YP_002343357.1 2058708 R 122587 CDS YP_002343358.1 218768846 907338 2059800..2060750 1 NC_003116.1 NMA2106, transcriptional regulator, len: 316aa; similar to many eg. SW:P06613 (CYSB_ECOLI) cysB, cys regulon transcriptional activator (324 aa) fasta scores; E(): 0, 50.6% identity in 316 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and Prosite match to PS00044 Bacterial regulatory proteins, lysR family signature.; transcriptional regulator CysB-like protein 2060750 907338 NMA2106 Neisseria meningitidis Z2491 transcriptional regulator CysB-like protein YP_002343358.1 2059800 D 122587 CDS YP_002343359.1 218768847 907337 complement(2060863..2061597) 1 NC_003116.1 NMA2107, anaerobic transcriptional regulatory protein, len: 244aa; similar to many eg. SW:P23926 (ANR_PSEAE) transcriptional activator protein Anr from seudomonas aeruginosa (244 aa) fasta scores; E(): 0, 47.8% identity in 226 aa overlap. Contains Pfam match to entry PF00027 cNMP_binding, Cyclic nucleotide-binding domain and Pfam match to entry PF00325 crp, Bacterial regulatory proteins, crp family. Contains helix-turn-helix motif 190-211aa (+3.65 SD).; anaerobic transcriptional regulatory protein 2061597 907337 NMA2107 Neisseria meningitidis Z2491 anaerobic transcriptional regulatory protein YP_002343359.1 2060863 R 122587 CDS YP_002343360.1 218768848 907336 2061798..2063219 1 NC_003116.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 2063219 hemN 907336 hemN Neisseria meningitidis Z2491 coproporphyrinogen III oxidase YP_002343360.1 2061798 D 122587 CDS YP_002343361.1 218768849 907335 complement(2063572..2065146) 1 NC_003116.1 NMA2109, phosphate permease, len: 524aa; similar to TR:Q50684 (EMBL:Z77163) phosphate permease from Mycobacterium tuberculosis (552 aa) fasta scores; E(): 0, 58.3% identity in 511 aa overlap. Contains Pfam match to entry PF01384 PHO4, Phosphate transporter family.; phosphate permease 2065146 907335 NMA2109 Neisseria meningitidis Z2491 phosphate permease YP_002343361.1 2063572 R 122587 CDS YP_002343362.1 218768850 907334 2065468..2066571 1 NC_003116.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 2066571 anmK 907334 anmK Neisseria meningitidis Z2491 anhydro-N-acetylmuramic acid kinase YP_002343362.1 2065468 D 122587 CDS YP_002343363.1 218768851 907333 2066691..2067632 1 NC_003116.1 NMA2112, mafA2, adhesin, len: 313aa; similar to TR:AAD31038 (EMBL:AF142582) MafA adhesin from Neisseria gonorrhoeae (320 aa) fasta scores; E(): 0, 62.4% identity in 314 aa overlap. Also similar to NMA0325 fasta scores; E(): 0, 62.4% identity in 314 aa overlap.; adhesin MafA2 2067632 907333 NMA2112 Neisseria meningitidis Z2491 adhesin MafA2 YP_002343363.1 2066691 D 122587 CDS YP_002343364.1 218768852 907332 2067636..2069132 1 NC_003116.1 NMA2113, mafB2, adhesin, len: 498aa; similar to TR:AAD31039 (EMBL:AF142582) adhesin MafB from Neisseria gonorrhoeae (509 aa) fasta scores; E(): 0, 30.7% identity in 514 aa overlap. Also similar to NMA0853 fasta scores; E(): 0, 38.6% identity in 412 aa overlap and NMA0324 fasta scores; E(): 0, 31.6% identity in 503 aa overlap.; adhesin MafB2 2069132 907332 NMA2113 Neisseria meningitidis Z2491 adhesin MafB2 YP_002343364.1 2067636 D 122587 CDS YP_002343365.1 218768853 907331 2069147..2069377 1 NC_003116.1 NMA2114, hypothetical protein, len: 2114aa; lies within a region of unusually low GC content.; hypothetical protein 2069377 907331 NMA2114 Neisseria meningitidis Z2491 hypothetical protein YP_002343365.1 2069147 D 122587 CDS YP_002343366.1 218768854 907330 2069526..2070200 1 NC_003116.1 NMA2115, hypothetical protein, len: 224aa; lies within a region of unusually low GC content.; hypothetical protein 2070200 907330 NMA2115 Neisseria meningitidis Z2491 hypothetical protein YP_002343366.1 2069526 D 122587 CDS YP_002343367.1 218768855 907329 2070178..2070459 1 NC_003116.1 NMA2116, hypothetical protein, len: 93aa; lies within a region of unusually low GC content.; hypothetical protein 2070459 907329 NMA2116 Neisseria meningitidis Z2491 hypothetical protein YP_002343367.1 2070178 D 122587 CDS YP_002343368.1 218768856 907328 2070639..2071124 1 NC_003116.1 NMA2117, hypothetical protein, len: 161aa; lies within a region of unusually low GC content.; hypothetical protein 2071124 907328 NMA2117 Neisseria meningitidis Z2491 hypothetical protein YP_002343368.1 2070639 D 122587 CDS YP_002343369.1 218768857 907327 2071193..2071570 1 NC_003116.1 NMA2118, hypothetical protein, len: 125aa; lies within a region of unusually low GC content.; hypothetical protein 2071570 907327 NMA2118 Neisseria meningitidis Z2491 hypothetical protein YP_002343369.1 2071193 D 122587 CDS YP_002343370.1 218768858 907326 2071875..2072276 1 NC_003116.1 NMA2120, hypothetical protein, len: 133aa; lies within a region of unusually low GC content.; hypothetical protein 2072276 907326 NMA2120 Neisseria meningitidis Z2491 hypothetical protein YP_002343370.1 2071875 D 122587 CDS YP_002343371.1 218768859 907325 2072376..2072891 1 NC_003116.1 NMA2121, hypothetical protein, len: 171aa; lies within a region of unusually low GC content.; hypothetical protein 2072891 907325 NMA2121 Neisseria meningitidis Z2491 hypothetical protein YP_002343371.1 2072376 D 122587 CDS YP_002343372.1 218768860 907324 2073056..2074180 1 NC_003116.1 NMA2122, hypothetical protein, len: 374aa; hypothetical protein 2074180 907324 NMA2122 Neisseria meningitidis Z2491 hypothetical protein YP_002343372.1 2073056 D 122587 CDS YP_002343373.1 218768861 907323 complement(2074267..2074542) 1 NC_003116.1 NMA2123, frpC', partial CDS, hypothetical protein, len: 91aa; highly similar to the N-terminus of SW:P55127 (FRPC_NEIME) iron-regulated protein FrpC from Neisseria meningitidis strain FAM20 (1829 aa) fasta scores; E(): 3.4e-29, 96.2% identity in 78 aa overlap.; hypothetical protein 2074542 907323 NMA2123 Neisseria meningitidis Z2491 hypothetical protein YP_002343373.1 2074267 R 122587 CDS YP_002343374.1 218768862 907322 complement(2074559..2075326) 1 NC_003116.1 NMA2124, outer membrane hypothetical protein, len: 255aa; strongly similar to TR:Q08840 (EMBL:L06299) hypothetical protein from Neisseria meningitidis strain FAM20 (271 aa) fasta scores; E(): 0,90.0% identity in 271 aa overlap.; hypothetical protein 2075326 907322 NMA2124 Neisseria meningitidis Z2491 hypothetical protein YP_002343374.1 2074559 R 122587 CDS YP_002343375.1 218768863 907321 complement(2075713..2075988) 1 NC_003116.1 NMA2126, hypothetical protein, len: 91aa; similar to TR:P95364 (EMBL:U82701) hypothetical protein from Neisseria gonorrhoeae (91 aa) fasta scores; E(): 0, 95.6% identity in 91 aa overlap.; hypothetical protein 2075988 907321 NMA2126 Neisseria meningitidis Z2491 hypothetical protein YP_002343375.1 2075713 R 122587 CDS YP_002343376.1 218768864 907320 complement(2075985..2077268) 1 NC_003116.1 NMA2127, integral membrane signal transducer protein, len: 427aa; similar to many eg. TR:P95363 (EMBL:U82701) hypothetical protein from Neisseria gonorrhoeae (427 aa) fasta scores; E(): 0, 97.9% identity in 427 aa overlap and SW:P36670 (AMPG_ECOLI) AmpG, signal transducer protein from Escherichia coli (491 aa) fasta scores; E(): 0, 40.2% identity in 398 aa overlap. Contains membrane-spanning hydrophobic regions.; integral membrane signal transducer protein 2077268 907320 NMA2127 Neisseria meningitidis Z2491 integral membrane signal transducer protein YP_002343376.1 2075985 R 122587 CDS YP_002343377.1 218768865 907319 complement(2077423..2078841) 1 NC_003116.1 NMA2128, glnA, glutamine synthetase, len: 472aa; strongly similar to many eg. TR:P95395 (EMBL:U82856) glnA,glutamine synthetase from Neisseria meningitidis strain M470 (468 aa) fasta scores; E(): 0, 99.6% identity in 468 aa overlap. Contains Pfam match to entry PF00120 gln-synt,Glutamine synthetase; Prosite match to PS00182 Glutamine synthetase class-I adenylation site; Prosite match to PS00181 Glutamine synthetase ATP-binding region signature and Prosite match to PS00180 Glutamine synthetase signature 1.; glutamine synthetase 2078841 907319 NMA2128 Neisseria meningitidis Z2491 glutamine synthetase YP_002343377.1 2077423 R 122587 CDS YP_002343378.1 218768866 907318 2079146..2079961 1 NC_003116.1 NMA2129, aroE, shikimate dehydrogenase, len: 271aa; strongly similar to many eg. TR:P95387 (EMBL:U82840) aroE,shikimate dehydrogenase from Neisseria meningitidis strain 44/76 (269 aa) fasta scores; E(): 0, 98.9% identity in 269 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase.; shikimate dehydrogenase 2079961 907318 NMA2129 Neisseria meningitidis Z2491 shikimate dehydrogenase YP_002343378.1 2079146 D 122587 CDS YP_002343379.1 218768867 907317 2079964..2080665 1 NC_003116.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 2080665 mtgA 907317 mtgA Neisseria meningitidis Z2491 monofunctional biosynthetic peptidoglycan transglycosylase YP_002343379.1 2079964 D 122587 CDS YP_002343380.1 218768868 907316 complement(2081256..2082020) 1 NC_003116.1 NMA2131, ABC transporter ATP-binding protein, len: 254aa; similar to many of undefined function eg. TR:O30650 (EMBL:AF013987) ABC transporter ATP-binding protein from Vibrio cholerae (241 aa) fasta scores; E(): 0, 61.5% identity in 239 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter; Prosite match to PS00211 ABC transporters family signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; ABC transporter ATP-binding protein 2082020 907316 NMA2131 Neisseria meningitidis Z2491 ABC transporter ATP-binding protein YP_002343380.1 2081256 R 122587 CDS YP_002343381.1 218768869 907315 complement(2082064..2082594) 1 NC_003116.1 NMA2132, outer membrane hypothetical protein, len: 176aa; similar to SW:P45074 (YHBN_HAEIN) hypothetical protein from Haemophilus influenzae fasta scores; E(): 4.3e-14, 39.5% identity in 172 aa overlap.; hypothetical protein 2082594 907315 NMA2132 Neisseria meningitidis Z2491 hypothetical protein YP_002343381.1 2082064 R 122587 CDS YP_002343382.1 218768870 907314 complement(2082575..2083156) 1 NC_003116.1 NMA2133, periplasmic hypothetical protein,len: 193aa; hypothetical protein 2083156 907314 NMA2133 Neisseria meningitidis Z2491 hypothetical protein YP_002343382.1 2082575 R 122587 CDS YP_002343383.1 218768871 907313 complement(2083153..2083689) 1 NC_003116.1 NMA2134, conserved hypothetical protein, len: 178aa; similar to many eg. SW:P45396 (YRBI_ECOLI) hypothetical protein from Escherichia coli (188 aa) fasta scores; E(): 1.5e-28, 46.0% identity in 174 aa overlap.; hypothetical protein 2083689 907313 NMA2134 Neisseria meningitidis Z2491 hypothetical protein YP_002343383.1 2083153 R 122587 CDS YP_002343384.1 218768872 907312 complement(2083907..2084881) 1 NC_003116.1 NMA2135, conserved hypothetical protein, len: 324aa; similar to many eg. SW:P45395 (YRBH_ECOLI) hypothetical protein from Escherichia coli (328 aa) fasta scores; E(): 0, 56.2% identity in 313 aa overlap. Contains two Pfam matches to entry PF00571 CBS, CBS domain and Pfam match to entry PF01380 SIS, SIS domain.; hypothetical protein 2084881 907312 NMA2135 Neisseria meningitidis Z2491 hypothetical protein YP_002343384.1 2083907 R 122587 CDS YP_002343385.1 218768873 907311 2084978..2086033 1 NC_003116.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 2086033 tal 907311 tal Neisseria meningitidis Z2491 transaldolase YP_002343385.1 2084978 D 122587 CDS YP_002343386.1 218768874 907310 2086186..2086476 1 NC_003116.1 NMA2137, hypothetical protein, len: 96aa; lies within a region of unusually low GC content.; hypothetical protein 2086476 907310 NMA2137 Neisseria meningitidis Z2491 hypothetical protein YP_002343386.1 2086186 D 122587 CDS YP_002343387.1 218768875 907309 2086493..2087380 1 NC_003116.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 2087380 907309 NMA2138 Neisseria meningitidis Z2491 glutamyl-Q tRNA(Asp) synthetase YP_002343387.1 2086493 D 122587 CDS YP_002343388.1 218768876 907308 complement(2087450..2088460) 1 NC_003116.1 NMA2139, conserved hypothetical protein, len: 336aa; similar to many eg. SW:P32695 (YJBN_ECOLI) hypothetical protein from Escherichia coli (330 aa) fasta scores; E(): 0, 54.4% identity in 318 aa overlap. Contains Pfam match to entry PF01207 UPF0034, Uncharacterized protein family UPF0034 and Prosite match to PS01136 Uncharacterized protein family UPF0034 signature.; tRNA-dihydrouridine synthase A 2088460 907308 NMA2139 Neisseria meningitidis Z2491 tRNA-dihydrouridine synthase A YP_002343388.1 2087450 R 122587 CDS YP_002343389.1 218768877 907307 complement(2088491..2088982) 1 NC_003116.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 2088982 907307 NMA2140 Neisseria meningitidis Z2491 D-tyrosyl-tRNA(Tyr) deacylase YP_002343389.1 2088491 R 122587 CDS YP_002343390.1 218768878 907306 complement(2089056..2089775) 1 NC_003116.1 NMA2141, hypothetical protein, len: 239aa; hypothetical protein 2089775 907306 NMA2141 Neisseria meningitidis Z2491 hypothetical protein YP_002343390.1 2089056 R 122587 CDS YP_002343391.1 218768879 907305 complement(2089885..2090751) 1 NC_003116.1 NMA2142, periplasmic hypothetical protein,len: 288aa; similar to SW:P37566 (YACD_BACSU) hypothetical protein from Bacillus subtilis (297 aa) fasta scores; E(): 7.7e-08, 22.6% identity in 292 aa overlap. Contains a cleavable N-terminal signal sequence.; hypothetical protein 2090751 907305 NMA2142 Neisseria meningitidis Z2491 hypothetical protein YP_002343391.1 2089885 R 122587 CDS YP_002343392.1 218768880 907304 complement(2090800..2091078) 1 NC_003116.1 NMA2143, conserved hypothetical protein, len: 92aa; similar to many eg. SW:P29943 (YCB1_PSEDE) hypothetical protein from Pseudomonas denitrificans (93 aa) fasta scores; E(): 4.2e-07, 37.8% identity in 90 aa overlap.; hypothetical protein 2091078 907304 NMA2143 Neisseria meningitidis Z2491 hypothetical protein YP_002343392.1 2090800 R 122587 CDS YP_002343393.1 218768881 907303 complement(2091078..2091368) 1 NC_003116.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 2091368 907303 NMA2144 Neisseria meningitidis Z2491 YciI-like protein YP_002343393.1 2091078 R 122587 CDS YP_002343394.1 218768882 907302 complement(2091371..2091901) 1 NC_003116.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 2091901 907302 NMA2145 Neisseria meningitidis Z2491 intracellular septation protein A YP_002343394.1 2091371 R 122587 CDS YP_002343395.1 218768883 907301 2092107..2094749 1 NC_003116.1 NMA2146, tspA, Neisseria-specific antigen protein,len: 880aa; identical to TR:O86394 (EMBL:AJ010113) tspA,Neisseria-specific antigen protein from Neisseria meningitidis strain B:15:P1.16. (880 aa).; hypothetical protein 2094749 907301 NMA2146 Neisseria meningitidis Z2491 hypothetical protein YP_002343395.1 2092107 D 122587 CDS YP_002343396.1 218768884 907300 complement(2094922..2095338) 1 NC_003116.1 NMA2147, gloA, lactoylglutathione lyase, len: 138aa; identical to SW:O33393 (LGUL_NEIME) gloA,lactoylglutathione lyase from Neisseria meningitidis strain B:15:P1.16 (138 aa). Similar to SW:Q60003 (LGUL_SALTY) gloA, lactoylglutathione lyase from Salmonella typhimurium (135 aa) fasta scores; E(): 0,67.7% identity in 127 aa overlap. Contains Pfam match to entry PF00903 Glyoxalase, Glyoxalase and Prosite match to PS00934 Glyoxalase I signature 1.; lactoylglutathione lyase 2095338 907300 NMA2147 Neisseria meningitidis Z2491 lactoylglutathione lyase YP_002343396.1 2094922 R 122587 CDS YP_002343397.1 218768885 907299 complement(2095362..2096531) 1 NC_003116.1 NMA2148, periplasmic hypothetical protein,len: 389aa; similar to SW:P45576 (YCIM_ECOLI) hypothetical protein from Escherichia coli (389 aa) fasta scores; E(): 1.5e-32, 29.2% identity in 387 aa overlap. Contains a cleavable N-terminal signal sequence.; tetratricopeptide repeat protein 2096531 907299 NMA2148 Neisseria meningitidis Z2491 tetratricopeptide repeat protein YP_002343397.1 2095362 R 122587 CDS YP_002343398.1 218768886 907298 complement(2096542..2096856) 1 NC_003116.1 NMA2149, inner membrane hypothetical protein, len: 104aa; weakly similar to TR:O32045 (EMBL:Z99118) hypothetical protein from Bacillus subtilis (107 aa) fasta scores; E(): 0.18, 35.0% identity in 80 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 2096856 907298 NMA2149 Neisseria meningitidis Z2491 hypothetical protein YP_002343398.1 2096542 R 122587 CDS YP_002343399.1 218768887 907296 2097166..2098164 1 NC_003116.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 2098164 ilvE 907296 ilvE Neisseria meningitidis Z2491 branched-chain amino acid aminotransferase YP_002343399.1 2097166 D 122587 CDS YP_002343400.1 218768888 907295 complement(2098349..2099134) 1 NC_003116.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 2099134 fabI 907295 fabI Neisseria meningitidis Z2491 enoyl-(acyl carrier protein) reductase YP_002343400.1 2098349 R 122587 CDS YP_002343401.1 218768889 907294 complement(2099289..2100110) 1 NC_003116.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 2100110 dapD 907294 dapD Neisseria meningitidis Z2491 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_002343401.1 2099289 R 122587 CDS YP_002343402.1 218768890 907293 complement(2100277..2101920) 1 NC_003116.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 2101920 pgi 907293 pgi Neisseria meningitidis Z2491 glucose-6-phosphate isomerase YP_002343402.1 2100277 R 122587 CDS YP_002343403.1 218768891 907292 2102277..2103509 1 NC_003116.1 NMA2155, pilG, pilus-assembly protein, len: 410aa; strongly similar to many eg. TR:Q57076 (EMBL:U32588) pilG,pilus-assembly protein from Neisseria gonorrhoeae (410 aa) fasta scores; E(): 0, 99.3% identity in 410 aa overlap. Contains Pfam match to entry PF00482 GSPII_F, Bacterial type II secretion system protein F domain and Prosite match to PS00874 Bacterial type II secretion system protein F signature. Also contains membrane-spanning hydrophobic regions.; pilus-assembly protein 2103509 907292 NMA2155 Neisseria meningitidis Z2491 pilus-assembly protein YP_002343403.1 2102277 D 122587 CDS YP_002343404.1 218768892 907291 2103583..2104443 1 NC_003116.1 NMA2156, pilD, type IV prepilin leader peptidase,len: 286aa; strongly similar to many eg. SW:P33566 (LEP3_NEIGO) pilD, type IV prepilin peptidase from Neisseria gonorrhoeae (286 aa) fasta scores; E(): 0, 96.1% identity in 285 aa overlap. Contains Pfam match to entry PF01478 Peptidase_C20, Type III leader peptidase family and membrane-spanning hydrophobic regions.; type IV prepilin leader peptidase 2104443 907291 NMA2156 Neisseria meningitidis Z2491 type IV prepilin leader peptidase YP_002343404.1 2103583 D 122587 CDS YP_002343405.1 218768893 907290 2104445..2105077 1 NC_003116.1 NMA2157, conserved hypothetical protein, len: 210aa; similar to many eg. SW:P36679 (YACE_ECOLI) hypothetical protein from Escherichia coli (206 aa) fasta scores; E(): 2.1e-19, 37.9% identity in 195 aa overlap. Contains Pfam match to entry PF01121 UPF0038,Uncharacterized protein family UPF0038 and Prosite match to PS01294 Uncharacterized protein family UPF0038 signature.; hypothetical protein 2105077 907290 NMA2157 Neisseria meningitidis Z2491 hypothetical protein YP_002343405.1 2104445 D 122587 CDS YP_002343406.1 218768894 907289 2105070..2105279 1 NC_003116.1 NMA2158, conserved hypothetical protein, len: 69aa; similar to others eg. TR:O69083 (EMBL:AF062531) hypothetical protein from Pseudomonas putida GB-1 (66 aa) fasta scores; E(): 1.4e-10, 50.8% identity in 61 aa overlap.; hypothetical protein 2105279 907289 NMA2158 Neisseria meningitidis Z2491 hypothetical protein YP_002343406.1 2105070 D 122587 CDS YP_002343407.1 218768895 907288 complement(2105364..2107040) 1 NC_003116.1 NMA2159, pilF, type IV pilus assembly protein, len: 558aa; strongly similar to many eg. SW:P37094 (PILF_NEIGO) pilF, type IV pilus assembly protein from Neisseria gonorrhoeae (558 aa) fasta scores; E(): 0, 99.3% identity in 558 aa overlap. Contains Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein; Prosite match to PS00662 Bacterial type II secretion system protein E signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; type IV pilus assembly protein 2107040 907288 NMA2159 Neisseria meningitidis Z2491 type IV pilus assembly protein YP_002343407.1 2105364 R 122587 CDS YP_002343408.1 218768896 907287 complement(2107484..2107930) 1 NC_003116.1 NMA2160, conserved hypothetical protein, len: 148aa; similar to many eg. SW:P44110 (YEAL_HAEIN) hypothetical protein from Haemophilus influenzae (150 aa) fasta scores; E(): 0, 63.3% identity in 147 aa overlap.; hypothetical protein 2107930 907287 NMA2160 Neisseria meningitidis Z2491 hypothetical protein YP_002343408.1 2107484 R 122587 CDS YP_002343409.1 218768897 907286 complement(2107935..2108909) 1 NC_003116.1 NMA2161, ispB, octaprenyl-diphosphate synthase,len: 324aa; similar to many eg. SW:P19641 (ISPB_ECOLI) ispB, octaprenyl-diphosphate synthase from Escherichia coli (323 aa) fasta scores; E(): 0, 53.4% identity in 320 aa overlap. Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases; Prosite match to PS00444 Polyprenyl synthetases signature 2 and Prosite match to PS00723 Polyprenyl synthetases signature 1.; octaprenyl-diphosphate synthase 2108909 907286 NMA2161 Neisseria meningitidis Z2491 octaprenyl-diphosphate synthase YP_002343409.1 2107935 R 122587 CDS YP_002343410.1 218768898 907285 2109133..2109441 1 NC_003116.1 NMA2162, rplU, 50S ribosomal protein L21, len: 102aa; strongly similar to many eg. SW:P02422 (RL21_ECOLI) rplU, 50S ribosomal protein L21 from Escherichia coli (103 aa) fasta scores; E(): 5.3e-21, 54.9% identity in 102 aa overlap. Contains Pfam match to entry PF00829 Ribosomal_L21p, Ribosomal prokaryotic L21 protein and Prosite match to PS01169 Ribosomal protein L21 signature.; 50S ribosomal protein L21 2109441 rplU 907285 rplU Neisseria meningitidis Z2491 50S ribosomal protein L21 YP_002343410.1 2109133 D 122587 CDS YP_002343411.1 218768899 907284 2109466..2109738 1 NC_003116.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 2109738 rpmA 907284 rpmA Neisseria meningitidis Z2491 50S ribosomal protein L27 YP_002343411.1 2109466 D 122587 CDS YP_002343412.1 218768900 907283 2110077..2111261 1 NC_003116.1 NMA2164, monooxygenase, len: 394aa; similar to many eg. SW:P25535 (VISC_ECOLI) hypothetical monooxygenase from Escherichia coli (400 aa) fasta scores; E(): 2.2e-27; 28.3% identity in 392 aa overlap and SW:P52019 (ERG1_MOUSE) squalene monooxygenase from Mus musculus (Mouse) (572 aa) fasta scores; E(): 0, 23.4% identity in 381 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase, Monooxygenase.; hypothetical protein 2111261 907283 NMA2164 Neisseria meningitidis Z2491 hypothetical protein YP_002343412.1 2110077 D 122587 CDS YP_002343413.1 218768901 907282 complement(2111532..2111687) 1 NC_003116.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2111687 rpmG 907282 rpmG Neisseria meningitidis Z2491 50S ribosomal protein L33 YP_002343413.1 2111532 R 122587 CDS YP_002343414.1 218768902 907281 complement(2111719..2111952) 1 NC_003116.1 required for 70S ribosome assembly; 50S ribosomal protein L28 2111952 rpmB 907281 rpmB Neisseria meningitidis Z2491 50S ribosomal protein L28 YP_002343414.1 2111719 R 122587 CDS YP_002343415.1 218768903 907279 complement(2112202..2113752) 1 NC_003116.1 NMA2168, emrB, multidrug resistance translocase,len: 516aa; strongly similar to many eg. SW:P27304 (EMRB_ECOLI) emrB, multidrug resistance translocase (512 aa) fasta scores; E(): 0, 57.5% identity in 504 aa overlap. Contains membrane-spanning hydrophobic regions.; multidrug resistance translocase 2113752 907279 NMA2168 Neisseria meningitidis Z2491 multidrug resistance translocase YP_002343415.1 2112202 R 122587 CDS YP_002343416.1 218768904 907278 complement(2113752..2114936) 1 NC_003116.1 NMA2169, emrA, multidrug resistance translocase,len: 394aa; similar to many eg. SW:P27303 (EMRA_ECOLI) emrA, multidrug resistance translocase from Escherichia coli (390 aa) fasta scores; E(): 0, 44.8% identity in 386 aa overlap. Contains Pfam match to entry PF00529 HlyD,HlyD family secretion protein; multidrug resistance translocase 2114936 907278 NMA2169 Neisseria meningitidis Z2491 multidrug resistance translocase YP_002343416.1 2113752 R 122587 CDS YP_002343417.1 218768905 907277 2115348..2115821 1 NC_003116.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2115821 907277 NMA2170 Neisseria meningitidis Z2491 7-cyano-7-deazaguanine reductase YP_002343417.1 2115348 D 122587 CDS YP_002343418.1 218768906 907276 2115898..2116584 1 NC_003116.1 NMA2171, conserved hypothetical inner membrane protein, len: 228aa; similar to many eg. SW:P37619 (YHHQ_ECOLI) hypothetical protein from Escherichia coli (221 aa) fasta scores; E(): 0, 66.5% identity in 209 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 2116584 907276 NMA2171 Neisseria meningitidis Z2491 hypothetical protein YP_002343418.1 2115898 D 122587 CDS YP_002343419.1 218768907 907275 complement(2117120..2118412) 1 NC_003116.1 NMA2172, conserved hypothetical protein, peptidase, len: 430aa; similar to many eg. SW:P44693 (YEBA_HAEIN) hypothetical protein from Haemophilus influenzae (475 aa) fasta scores; E(): 4.6e-23, 31.0% identity in 387 aa overlap. Contains Pfam match to entry PF01551 Peptidase_M37.; hypothetical protein 2118412 907275 NMA2172 Neisseria meningitidis Z2491 hypothetical protein YP_002343419.1 2117120 R 122587 CDS YP_002343420.1 218768908 907274 2118490..2119458 1 NC_003116.1 NMA2173, hypothetical protein, len: 322aa; hypothetical protein 2119458 907274 NMA2173 Neisseria meningitidis Z2491 hypothetical protein YP_002343420.1 2118490 D 122587 CDS YP_002343421.1 218768909 907273 complement(2119659..2121131) 1 NC_003116.1 NMA2174, conserved hypothetical protein, len: 490aa; similar to many eg. TR:Q9ZF57 (EMBL:AF118122) outer membrane protein from Neisseria meningitidis strain 8013#6 (488 aa) fasta scores; E(): 0,99.2% identity in 488 aa overlap and TR:O85049 (EMBL:AF039312) hypothetical protein from Moraxella catarrhalis (512 aa) fasta scores; E(): 0, 41.5% identity in 458 aa overlap.; hypothetical protein 2121131 907273 NMA2174 Neisseria meningitidis Z2491 hypothetical protein YP_002343421.1 2119659 R 122587 CDS YP_002343422.1 218768910 907272 complement(2121367..2123226) 1 NC_003116.1 NMA2175, vapA, virulence associated protein, len: 619aa; strongly similar to TR:Q9ZF58 (EMBL:AF118122) vapA, virulence associated protein from Neisseria meningitidis strain 8013#6 (619 aa) fasta scores; E(): 0, 98.4% identity in 619 aa overlap.; virulence associated protein 2123226 907272 NMA2175 Neisseria meningitidis Z2491 virulence associated protein YP_002343422.1 2121367 R 122587 CDS YP_002343423.1 218768911 907271 complement(2124655..2124900) 1 NC_003116.1 NMA2176, hypothetical protein, len: 81aa; hypothetical protein 2124900 907271 NMA2176 Neisseria meningitidis Z2491 hypothetical protein YP_002343423.1 2124655 R 122587 CDS YP_002343424.1 218768912 907270 2125003..2125440 1 NC_003116.1 NMA2177, conserved hypothetical inner membrane protein, len: 145aa; similar to many eg. TR:Q9ZJD5 (EMBL:AE001560) hypothetical protein from Helicobacter pylori J99 (148 aa) fasta scores; E(): 3.9e-15, 40.7% identity in 145 aa overlap. Contains membrane-spanning hydrophobic regions.; conserved hypothetical inner membrane protein 2125440 907270 NMA2177 Neisseria meningitidis Z2491 conserved hypothetical inner membrane protein YP_002343424.1 2125003 D 122587 CDS YP_002343425.1 218768913 907269 2125452..2125928 1 NC_003116.1 NMA2178, conserved hypothetical protein, len: 158aa; similar to TR:Q55960 (EMBL:D64005) hypothetical protein from Synechocystis sp. (strain PCC 6803) (154 aa) fasta scores; E(): 5.8e-28, 44.5% identity in 155 aa overlap.; hypothetical protein 2125928 907269 NMA2178 Neisseria meningitidis Z2491 hypothetical protein YP_002343425.1 2125452 D 122587 CDS YP_002343426.1 218768914 907268 complement(2126278..2126766) 1 NC_003116.1 NMA2179, folA, dihydrofolate reductase, len: 162aa; similar to many eg. SW:P12833 (DYR3_SALTY) dhfrIII,dihydrofolate reductase type III from Salmonella typhimurium (162 aa) fasta scores; E(): 2.1e-26, 50.7% identity in 152 aa overlap. Contains Pfam match to entry PF00186 DiHfolate_red, Dihydrofolate reductase and Prosite match to PS00075 Dihydrofolate reductase signature.; dihydrofolate reductase 2126766 907268 NMA2179 Neisseria meningitidis Z2491 dihydrofolate reductase YP_002343426.1 2126278 R 122587 CDS YP_002343427.1 218768915 907267 complement(2126834..2127889) 1 NC_003116.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 2127889 aroG 907267 aroG Neisseria meningitidis Z2491 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002343427.1 2126834 R 122587 CDS YP_002343428.1 218768916 907266 2127943..2128308 1 NC_003116.1 NMA2181, hypothetical protein (improbable CDS),len: 121aa; hypothetical protein 2128308 907266 NMA2181 Neisseria meningitidis Z2491 hypothetical protein YP_002343428.1 2127943 D 122587 CDS YP_002343429.1 218768917 907265 2128354..2128446 1 NC_003116.1 NMA2182, hypothetical protein (improbable CDS),len: 30aa; hypothetical protein 2128446 907265 NMA2182 Neisseria meningitidis Z2491 hypothetical protein YP_002343429.1 2128354 D 122587 CDS YP_002343430.1 218768918 907262 complement(2129169..2129822) 1 NC_003116.1 NMA2185, insertion element IS1016C2 transposase, len: 217aa; similar to many eg. TR:Q48234 (EMBL:X59756) insertion sequence IS1016-V6 from Haemophilus influenzae (191 aa) fasta scores; E(): 0,70.3% identity in 175 aa overlap. Also highly similar to many others from Neisseria meningitidis eg. NMA0471,NMA0769.; insertion element IS1016C2 transposase 2129822 907262 NMA2185 Neisseria meningitidis Z2491 insertion element IS1016C2 transposase YP_002343430.1 2129169 R 122587 CDS YP_002343431.1 218768919 907261 complement(2129942..2130400) 1 NC_003116.1 NMA2186, hypothetical protein, len: 152aa; similar to TR:CAB44963 (EMBL:AJ242838) hypothetical protein from Neisseria meningitidis serogroup C strain FAM18 (148 aa) fasta scores; E(): 0, 97.2% identity in 145 aa overlap; hypothetical protein 2130400 907261 NMA2186 Neisseria meningitidis Z2491 hypothetical protein YP_002343431.1 2129942 R 122587 CDS YP_002343432.1 218768920 907260 complement(2130512..2130976) 1 NC_003116.1 NMA2187, DNA transport competence protein,len: 154 aa; region of similarity to SW:P39694 (CME1_BACSU) ComE a late competence operon protein from Bacillus subtilis (205 aa) fasta scores; E(): 9.8e-07,47.6% identity in 63 aa overlap. Previously sequenced therefore identical to TR:CAB44958 (EMBL:AJ242837) ComEA protein (fragment) from Neisseria meningitidis serogroup A strain Z2491 (170 aa) fasta scores; E(): 0, 100.0% identity in 154 aa overlap. Contains Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif and membrane-spanning hydrophobic region. Identical to NMA1915, and almost identical to NMA0211 (98.7% identity in 154 aa overlap), and NMA0423 (98.7% identity in 154 aa overlap); DNA transport competence protein 2130976 907260 NMA2187 Neisseria meningitidis Z2491 DNA transport competence protein YP_002343432.1 2130512 R 122587 CDS YP_002343433.1 218768921 907258 complement(2136776..2137582) 1 NC_003116.1 NMA2189, hypothetical inner membrane protein, len: 268aa; weakly similar to many eg. TR:P76599 (EMBL:AE000347) hypothetical protein from Escherichia coli (288 aa) fasta scores; E(): 8.2e-13, 27.3% identity in 249 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 2137582 907258 NMA2189 Neisseria meningitidis Z2491 hypothetical protein YP_002343433.1 2136776 R 122587 CDS YP_002343434.1 218768922 907257 2137803..2139173 1 NC_003116.1 NMA2190, ffh, signal recognition particle protein,len: 456aa; strongly similar to many eg. SW:P07019 (SR54_ECOLI) ffh, signal recognition particle protein from Escherichia coli (453 aa) fasta scores; E(): 0, 67.3% identity in 455 aa overlap. Contains Pfam match to entry PF00448 SRP54, SRP54-type protein; Prosite match to PS00300 SRP54-type proteins GTP-binding domain signature and potential coiled-coil region close to the N-terminus.; signal recognition particle protein 2139173 907257 NMA2190 Neisseria meningitidis Z2491 signal recognition particle protein YP_002343434.1 2137803 D 122587 CDS YP_002343435.1 218768923 907256 complement(2139504..2140199) 1 NC_003116.1 NMA2191, thiol:disulphide interchange protein, len: 231aa; weakly similar to many eg. SW:P2499 (DSBA_ECOLI) DsbA, thiol:disulphide interchange protein from Escherichia coli (208 aa) fasta scores; E(): 5.3e-10,30.8% identity in 198 aa overlap. Also similar to NMA2209 (fasta scores; E(): 0, 73.5% identity in 230 aa overlap). Contains Pfam match to entry PF01323 DSBA, DSBA oxidoreductase and Prosite match to PS00194 Thioredoxin family active site. Contains a cleavable N-terminal signal sequence.; thiol:disulfide interchange protein 2140199 907256 NMA2191 Neisseria meningitidis Z2491 thiol:disulfide interchange protein YP_002343435.1 2139504 R 122587 CDS YP_002343436.1 218768924 907255 complement(2140370..2141029) 1 NC_003116.1 NMA2192, conserved hypothetical protein, len: 219aa; similar to TR:O25892 (EMBL:AE000635) hypothetical protein from Helicobacter pylori (Campylobacter pylori) (224 aa) fasta scores; E(): 0, 47.5% identity in 223 aa overlap. Lies in a region of unusually low GC content.; hypothetical protein 2141029 907255 NMA2192 Neisseria meningitidis Z2491 hypothetical protein YP_002343436.1 2140370 R 122587 CDS YP_002343437.1 218768925 907254 complement(2141227..2143338) 1 NC_003116.1 NMA2193, TonB-dependent receptor protein,len: 703aa; similar to many eg. SW:P48632 (FPVA_PSEAE) ferripyoverdine receptor from Pseudomonas aeruginosa (813 aa) fasta scores; E(): 2.4e-18, 24.1% identity in 602 aa overlap. Contains Pfam match to entry PF00593 TonB_boxC,TonB dependent receptor C-terminal region.; TonB-dependent receptor protein 2143338 907254 NMA2193 Neisseria meningitidis Z2491 TonB-dependent receptor protein YP_002343437.1 2141227 R 122587 CDS YP_002343438.1 218768926 907253 complement(2143524..2144129) 1 NC_003116.1 NMA2195, hypothetical protein, len: 201aa; similar to SW:P37261 (YC08_YEAST) hypothetical protein from Saccharomyces cerevisiae (Baker's yeast) (192 aa) fasta scores; E(): 3.2e-12, 32.1% identity in 184 aa overlap.; hypothetical protein 2144129 907253 NMA2195 Neisseria meningitidis Z2491 hypothetical protein YP_002343438.1 2143524 R 122587 CDS YP_002343439.1 218768927 907252 complement(2144178..2144576) 1 NC_003116.1 NMA2196, conserved hypothetical inner membrane protein, len: 132aa; similar to many eg. SW:P44069 (Y886_HAEIN) hypothetical protein from Haemophilus influenzae (134 aa) fasta scores; E(): 5.1e-24, 55.0% identity in 129 aa overlap. Contains membrane-spanning hydrophobic regions.; conserved hypothetical inner membrane protein 2144576 907252 NMA2196 Neisseria meningitidis Z2491 conserved hypothetical inner membrane protein YP_002343439.1 2144178 R 122587 CDS YP_002343440.1 218768928 907251 2144684..2145595 1 NC_003116.1 NMA2197, probable LysR-family transcriptional regulator, len: 303aa; similar to many eg. TR:AAD33772 (EMBL:AF139107) hypothetical transcriptional activator from Pseudomonas aeruginosa (306 aa) fasta scores; E(): 6.1e-29, 33.4% identity in 290 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and Prosite match to PS00044 Bacterial regulatory proteins, lysR family signature.; LysR-family transcriptional regulator 2145595 907251 NMA2197 Neisseria meningitidis Z2491 LysR-family transcriptional regulator YP_002343440.1 2144684 D 122587 CDS YP_002343441.1 218768929 907250 2145585..2146886 1 NC_003116.1 NMA2198, phr, deoxyribodopyrimidine photolyase,len: 433aa; similar to many eg. SW:P00914 (PHR_ECOLI) phr,deoxyribodopyrimidine photolyase from Escherichia coli (472 aa) fasta scores; E(): 8.2e-15, 30.4% identity in 457 aa overlap. Contains Pfam match to entry PF00875 DNA_photolyase, DNA photolyase and Prosite match to PS00394 DNA photolyases class 1 signature 1.; deoxyribodopyrimidine photolyase 2146886 907250 NMA2198 Neisseria meningitidis Z2491 deoxyribodopyrimidine photolyase YP_002343441.1 2145585 D 122587 CDS YP_002343442.1 218768930 7163869 complement(join(2146979..2147200,2147199..2147207)) 1 NC_003116.1 NMA2199, hypothetical inner membrane protein, len: 76aa; contains membrane-spanning hydrophobic regions.; hypothetical protein 2147207 7163869 NMA2199 Neisseria meningitidis Z2491 hypothetical protein YP_002343442.1 2146979 R 122587 CDS YP_002343443.1 218768931 907248 2147279..2149429 1 NC_003116.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 2149429 dinG 907248 dinG Neisseria meningitidis Z2491 ATP-dependent DNA helicase DinG YP_002343443.1 2147279 D 122587 CDS YP_002343444.1 218768932 907247 2149465..2150079 1 NC_003116.1 NMA2201, hypothetical protein, len: 204aa; similar to SW:P33218 (YEBE_ECOLI) hypothetical protein from Escherichia coli (219 aa) fasta scores; E(): 3.1e-07,29.2% identity in 212 aa overlap.; hypothetical protein 2150079 907247 NMA2201 Neisseria meningitidis Z2491 hypothetical protein YP_002343444.1 2149465 D 122587 CDS YP_002343445.1 218768933 907246 complement(2150174..2152042) 1 NC_003116.1 NMA2202, inner membrane trans-acylase, len: 622aa; similar to TR:P74874 (EMBL:U65941) OafA integral membrane trans-acylase from Salmonella typhimurium (609 aa) fasta scores; E(): 4.9e-23, 31.4% identity in 488 aa overlap. Regions of similarity to others eg. 40-280aa similar to SW:P43993 (Y392_HAEIN) hypothetical protein from Haemophilus influenzae (245 aa) fasta scores; E(): 0, 60.7% identity in 239 aa overlap. Contains membrane-spanning hydrophobic regions.; inner membrane trans-acylase 2152042 907246 NMA2202 Neisseria meningitidis Z2491 inner membrane trans-acylase YP_002343445.1 2150174 R 122587 CDS YP_002343446.1 218768934 907245 complement(2152123..2153493) 1 NC_003116.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 2153493 purB 907245 purB Neisseria meningitidis Z2491 adenylosuccinate lyase YP_002343446.1 2152123 R 122587 CDS YP_002343447.1 218768935 907244 complement(2153565..2154197) 1 NC_003116.1 NMA2204, hypothetical protein, len: 210aa; similar to TR:Q46063 (EMBL:X81379) hypothetical protein from Corynebacterium glutamicum (211 aa) fasta scores; E(): 5.7e-30, 52.5% identity in 160 aa overlap.; hypothetical protein 2154197 907244 NMA2204 Neisseria meningitidis Z2491 hypothetical protein YP_002343447.1 2153565 R 122587 CDS YP_002343448.1 218768936 907243 2154506..2156386 1 NC_003116.1 NMA2205, hypothetical protein, len: 635aa; hypothetical protein 2156386 907243 NMA2205 Neisseria meningitidis Z2491 hypothetical protein YP_002343448.1 2154506 D 122587 CDS YP_002343449.1 218768937 907242 complement(2157620..2158663) 1 NC_003116.1 NMA2206, rotamase, len: 347aa; weakly similar to many eg. SW:P21202 (SURA_ECOLI) SurA, survival protein from Escherichia coli (428 aa) fasta scores; E(): 4.7e-09, 26.1% identity in 303 aa overlap. Contains Pfam match to entry PF00639 Rotamase, PPIC-type PPIASE domain and PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature; rotamase 2158663 907242 NMA2206 Neisseria meningitidis Z2491 rotamase YP_002343449.1 2157620 R 122587 CDS YP_002343450.1 218768938 907241 complement(2158786..2161194) 1 NC_003116.1 NMA2207, solvent tolerance protein, len: 802aa; similar to SW:P31554 (OSTA_ECOLI) solvent tolerance protein from Escherichia coli (784 aa) fasta scores; E(): 1.4e-30, 27.9% identity in 768 aa overlap.; solvent tolerance protein 2161194 907241 NMA2207 Neisseria meningitidis Z2491 solvent tolerance protein YP_002343450.1 2158786 R 122587 CDS YP_002343451.1 218768939 907240 2161264..2162268 1 NC_003116.1 NMA2208, hypothetical protein, len: 334aa; similar to TR:AAD22455 (EMBL:AF116284) hypothetical protein from Pseudomonas aeruginosa (338 aa) fasta scores; E(): 0,44.0% identity in 332 aa overlap.; hypothetical protein 2162268 907240 NMA2208 Neisseria meningitidis Z2491 hypothetical protein YP_002343451.1 2161264 D 122587 CDS YP_002343452.1 218768940 907239 complement(2162325..2163023) 1 NC_003116.1 NMA2209, thiol:disulphide interchange protein, len: 232aa; weakly similar to many eg. SW:P52234 (DSBA_ERWCH) DsbA, thiol:disulphide interchange protein from Erwinia chrysanthemi (207 aa) fasta scores; E(): 7e-06, 26.4% identity in 193 aa overlap. Also similar to NMA2191 (fasta scores; E(): 0, 73.5% identity in 230 aa overlap). Contains Pfam match to entry PF01323 DSBA, DSBA oxidoreductase and Prosite match to PS00194 Thioredoxin family active site. Contains a cleavable N-terminal signal sequence.; thiol:disulfide interchange protein 2163023 907239 NMA2209 Neisseria meningitidis Z2491 thiol:disulfide interchange protein YP_002343452.1 2162325 R 122587 CDS YP_002343453.1 218768941 907238 2163482..2165020 1 NC_003116.1 NMA2210, inner membrane virulence factor protein, len: 512aa; similar to many MviN virulence factor homologs eg. SW:P37169 (MVIN_SALTY) from Salmonella typhimurium (524 aa) fasta scores; E(): 0, 63.5% identity in 509 aa overlap. Contains membrane-spanning hydrophobic regions.; inner membrane virulence factor protein 2165020 907238 NMA2210 Neisseria meningitidis Z2491 inner membrane virulence factor protein YP_002343453.1 2163482 D 122587 CDS YP_002343454.1 218768942 907237 2165153..2166109 1 NC_003116.1 NMA2211, conserved hypothetical protein, len: 318aa; similar to many eg. SW:P45524 (YHET_ECOLI) hypothetical protein from Escherichia coli (340 aa) fasta scores; E(): 0, 36.6% identity in 314 aa overlap. Contains PS01133 Uncharacterized protein family UPF0017 signature.; hypothetical protein 2166109 907237 NMA2211 Neisseria meningitidis Z2491 hypothetical protein YP_002343454.1 2165153 D 122587 CDS YP_002343455.1 218768943 907236 2166160..2166942 1 NC_003116.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 2166942 trpC 907236 trpC Neisseria meningitidis Z2491 indole-3-glycerol-phosphate synthase YP_002343455.1 2166160 D 122587 CDS YP_002343456.1 218768944 907235 2167007..2169307 1 NC_003116.1 NMA2213, recQ, ATP-dependent DNA helicase, len: 801aa; similar to many eg. SW:P15043 (RECQ_ECOLI) recQ,ATP-dependent DNA helicase from Escherichia coli (607 aa) fasta scores; E(): 0, 47.1% identity in 594 aa overlap. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase; Pfam match to entry PF00271 helicase_C,Helicases conserved C-terminal domain and two Pfam matches to entry PF00570 HRDC, HRDC domain.; ATP-dependent DNA helicase 2169307 907235 NMA2213 Neisseria meningitidis Z2491 ATP-dependent DNA helicase YP_002343456.1 2167007 D 122587 CDS YP_002343457.1 218768945 907234 complement(2169450..2170076) 1 NC_003116.1 NMA2214, hypothetical protein, len: 208aa; hypothetical protein 2170076 907234 NMA2214 Neisseria meningitidis Z2491 hypothetical protein YP_002343457.1 2169450 R 122587 CDS YP_002343458.1 218768946 907233 complement(2170152..2170940) 1 NC_003116.1 NMA2215, hypothetical protein, len: 262aa; hypothetical protein 2170940 907233 NMA2215 Neisseria meningitidis Z2491 hypothetical protein YP_002343458.1 2170152 R 122587 CDS YP_002343459.1 218768947 907232 complement(2170774..2171712) 1 NC_003116.1 NMA2216, hydrolase, len: 312aa; similar to TR:O67982 (EMBL:AF003947) 3-oxoadipate enol-lactone-hydrolase/4-carboxymuconolactone-decarboxyla se from Rhodococcus opacus (400 aa) fasta scores; E(): 3.9e-10, 28.7% identity in 265 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.; hydrolase 2171712 907232 NMA2216 Neisseria meningitidis Z2491 hydrolase YP_002343459.1 2170774 R 122587 CDS YP_002343460.1 218768948 907231 2171684..2172409 1 NC_003116.1 NMA2217, hypothetical protein, len: 246aa; similar to others of undefined function eg. SW:P31773 (COMF_HAEIN) competence protein from Haemophilus influenzae (229 aa) fasta scores; E(): 1.4e-17, 32.5% identity in 231 aa overlap.; hypothetical protein 2172409 907231 NMA2217 Neisseria meningitidis Z2491 hypothetical protein YP_002343460.1 2171684 D 122587 CDS YP_002343461.1 218768949 907230 2172474..2172938 1 NC_003116.1 NMA2218, tRNA/rRNA methyltransferase, len: 154aa; similar to many eg. SW:P33899 (YIBK_ECOLI) hypothetical tRNA/rRNA methyltransferase from Escherichia coli (157 aa) fasta scores; E(): 0, 62.3% identity in 154 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family.; tRNA/rRNA methyltransferase 2172938 907230 NMA2218 Neisseria meningitidis Z2491 tRNA/rRNA methyltransferase YP_002343461.1 2172474 D 122587 CDS YP_002343462.1 218768950 907229 2173066..2173785 1 NC_003116.1 NMA2219, periplasmic protein, len: 239aa; weakly similar to many of undefined function eg. TRNEW:AAD32233 (EMBL:AF147448) from Pseudomonas aeruginosa (342 aa) fasta scores; E(): 4.2e-24, 40.5% identity in 232 aa overlap.; hypothetical protein 2173785 907229 NMA2219 Neisseria meningitidis Z2491 hypothetical protein YP_002343462.1 2173066 D 122587 CDS YP_002343463.1 218768951 907228 2173785..2174165 1 NC_003116.1 NMA2220, hypothetical protein, len: 126aa; hypothetical protein 2174165 907228 NMA2220 Neisseria meningitidis Z2491 hypothetical protein YP_002343463.1 2173785 D 122587 CDS YP_002343464.1 218768952 907227 2174247..2174831 1 NC_003116.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2174831 ruvA 907227 ruvA Neisseria meningitidis Z2491 Holliday junction DNA helicase RuvA YP_002343464.1 2174247 D 122587 CDS YP_002343465.1 218768953 907225 2174994..2176850 1 NC_003116.1 NMA2223, probable ABC transporter, len: 618aa; similar to many eg. SW:Q57180 (YA51_HAEIN) hypothetical ABC transporter from Haemophilus influenzae (614 aa) fasta scores; E(): 0, 76.5% identity in 614 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter; Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00211 ABC transporters family signature; ABC transporter 2176850 907225 NMA2223 Neisseria meningitidis Z2491 ABC transporter YP_002343465.1 2174994 D 122587 CDS YP_002343466.1 218768954 907224 2176855..2177778 1 NC_003116.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 2177778 907224 NMA2224 Neisseria meningitidis Z2491 ribosome-associated GTPase YP_002343466.1 2176855 D 122587 CDS YP_002343467.1 218768955 907223 2178042..2178266 1 NC_003116.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 2178266 907223 NMA2225 Neisseria meningitidis Z2491 exodeoxyribonuclease VII small subunit YP_002343467.1 2178042 D 122587 CDS YP_002343468.1 218768956 907222 2178250..2179146 1 NC_003116.1 NMA2226, ispA, geranyltranstransferase, len: 298aa; similar to many eg. SW:P22939 (ISPA_ECOLI) ispA,geranyltranstransferase from Escherichia coli (299 aa) fasta scores; E(): 0, 49.1% identity in 289 aa overlap. Contains Pfam match to entry PF00348 polyprenyl_synt,Polyprenyl synthetases; Prosite match to PS00723 Polyprenyl synthetases signature 1 and Prosite match to PS00444 Polyprenyl synthetases signature 2.; geranyltranstransferase 2179146 907222 NMA2226 Neisseria meningitidis Z2491 geranyltranstransferase YP_002343468.1 2178250 D 122587 CDS YP_002343469.1 218768957 907221 complement(2179255..2179605) 1 NC_003116.1 NMA2227, hypothetical inner membrane protein, len: 116aa; Contains membrane-spanning hydrophobic regions.; hypothetical protein 2179605 907221 NMA2227 Neisseria meningitidis Z2491 hypothetical protein YP_002343469.1 2179255 R 122587 CDS YP_002343470.1 218768958 907220 complement(2179666..2181111) 1 NC_003116.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2181111 nuoN 907220 nuoN Neisseria meningitidis Z2491 NADH dehydrogenase subunit N YP_002343470.1 2179666 R 122587 CDS YP_002343471.1 218768959 907219 complement(2181121..2182617) 1 NC_003116.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2182617 nuoM 907219 nuoM Neisseria meningitidis Z2491 NADH dehydrogenase subunit M YP_002343471.1 2181121 R 122587 CDS YP_002343472.1 218768960 907218 complement(2182654..2184369) 1 NC_003116.1 NMA2230, hypothetical protein, len: 571aa; weakly similar to many eg. TR:O34810 (EMBL:AE000641) hypothetical protein from Helicobacter pylori (Campylobacter pylori) (578 aa) fasta scores; E(): 3e-21, 23.2% identity in 604 aa overlap. Lies in a region of unusually low GC content.; hypothetical protein 2184369 907218 NMA2230 Neisseria meningitidis Z2491 hypothetical protein YP_002343472.1 2182654 R 122587 CDS