-- dump date 20140619_163809 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 122587000001 SEQ_END SEQ_END NC_003116.1 2184406 2184406 DR NC_003116.1; contig end 2184406..2184406 Neisseria meningitidis Z2491 YP_002341564.1 CDS NMA0001 NC_003116.1 38 358 R NMA0001, unknown, len: 106 aa; hypothetical protein complement(38..358) Neisseria meningitidis Z2491 906018 YP_002341565.1 CDS nuoL NC_003116.1 414 2438 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(414..2438) Neisseria meningitidis Z2491 906019 YP_002341566.1 CDS NMA0003 NC_003116.1 2487 2828 R NMA0003, unknown, len: 113 aa; hypothetical protein complement(2487..2828) Neisseria meningitidis Z2491 906020 YP_002341567.1 CDS NMA0004 NC_003116.1 2952 3527 R NMA0004, unknown, len: 191 aa; similar to hypothetical proteins e.g. Y977_HAEIN HI0977 (191 aa),fasta scores; E(): 0; 80.5% identity in 190 aa overlap, and to proteins involved in cell cycle e.g. TR:O54679 (EMBL:AF036487) Lactococcus lactis Plasmid pNZ4000 mobilization protein (200 aa), fasta scores; E(): 0, 55.1% identity in 167 aa overlap, and FIC_ECOLI cell filamentation protein FIC (200 aa), fasta scores; E(): 0.093, 29.4% identity in 126 aa overlap; hypothetical protein complement(2952..3527) Neisseria meningitidis Z2491 906021 YP_002341568.1 CDS nuoK NC_003116.1 3561 3866 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(3561..3866) Neisseria meningitidis Z2491 906022 YP_002341569.1 CDS NMA0006 NC_003116.1 3863 4534 R NMA0006, nuoJ, NADH dehydrogenase I chain J, len: 223 aa; similar to many e.g. NUOJ_RHOCA NADH dehydrogenase I chain J (EC 1.6.5.3) (202 aa), fatsa scores; E(): 9.7e-21; 41.3% identity in 201 aa overlap. Contains Pfam match to entry PF00499 oxidored_q3,NADH-ubiquinone/plastoquinone oxidoreductase chain 6; NADH dehydrogenase I subunit J complement(3863..4534) Neisseria meningitidis Z2491 906023 YP_002341570.1 CDS NMA0007 NC_003116.1 4570 5277 R NMA0007, unknown, len: 235 aa; hypothetical protein complement(4570..5277) Neisseria meningitidis Z2491 906024 YP_002341571.1 CDS nuoI NC_003116.1 5308 5787 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(5308..5787) Neisseria meningitidis Z2491 906025 YP_002341572.1 CDS NMA0009 NC_003116.1 5867 6943 R NMA0009, nuoH, NADH dehydrogenase I chain H, len: 358 aa; similar to many e.g. NUOH_RHOCA NADH dehydrogenase I chain H (EC 1.6.5.3) (345 aa), fasta scores; E(): 0,46.4% identity in 332 aa overlap. Contains Pfam match to entry PF00146 NADHdh, NADH dehydrogenases, and PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2; NADH dehydrogenase I subunit H complement(5867..6943) Neisseria meningitidis Z2491 906027 YP_002341573.1 CDS nuoG NC_003116.1 6946 9207 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G complement(6946..9207) Neisseria meningitidis Z2491 906028 YP_002341574.1 CDS NMA0011 NC_003116.1 9489 9758 R NMA0011, unknown, len: 89 aa; similar to TR:O33368 (EMBL:AJ002423) N.g. hypothetical 11.4 kd protein (94 aa),fasta scores; E(): 1.1e-16; 53.0% identity in 83 aa overlap. Also similar to NMA0292, fasta scores; E(): 5.4e-19; 54.2% identity in 83 aa overlap; hypothetical protein complement(9489..9758) Neisseria meningitidis Z2491 906029 YP_002341575.1 CDS NMA0013 NC_003116.1 10044 10481 R NMA0013, unknown, len: 145 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein complement(10044..10481) Neisseria meningitidis Z2491 906031 YP_002341576.1 CDS NMA0014 NC_003116.1 10481 11782 R NMA0014, nuoF, NADH dehydrogenase I chain F, len: 433 aa; similar to many e.g. NQO1_THETH NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3) (438 aa), fasta scores; E(): 0; 50.0% identity in 414 aa overlap, and SW:NUOF_ECOLI P31979 NADH dehydrogenase I chain F (EC 1.6.5.3) (445 aa), blastp scores Expect = 2.8e-93. Contains PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2; NADH dehydrogenase I subunit F complement(10481..11782) Neisseria meningitidis Z2491 906032 YP_002341577.1 CDS nuoE NC_003116.1 12172 12645 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(12172..12645) Neisseria meningitidis Z2491 906033 YP_002341578.1 CDS nuoD NC_003116.1 12645 13901 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D complement(12645..13901) Neisseria meningitidis Z2491 906034 YP_002341579.1 CDS nuoC NC_003116.1 13891 14484 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C complement(13891..14484) Neisseria meningitidis Z2491 906036 YP_002341580.1 CDS nuoB NC_003116.1 14497 14979 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(14497..14979) Neisseria meningitidis Z2491 906037 YP_002341581.1 CDS NMA0019 NC_003116.1 14970 15326 R NMA0019, nuoA, NADH dehydrogenase I chain A, len: 118 aa; similar to many eg. NU3M_PLASU NADH-ubiquinone oxidoreductase chain 3 (EC 1.6.5.3) (117 aa), fastscores; E(): 8.3e-28, 55.3% identity in 114 aa overlap, and NUOA_ECOLI P33597 NADH dehydrogenase I chain A (EC 1.6.5.3) (147 aa), blastp scores; Expect = 7.1e-17; 33% identity in 112 aa overlap. Contains Pfam match to entry PF00507 oxidored_q4, NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; NADH dehydrogenase I subunit A complement(14970..15326) Neisseria meningitidis Z2491 906038 YP_002341582.1 CDS NMA0020 NC_003116.1 15777 17261 R NMA0020, probable integral membrane protein, len: 494 aa; weak similarity to TR:O33279 (EMBL:AL008687) Mycobacterium tuberculosis spermidine synthase speE (523 aa), fasta scores; E(): 0.00015, 24.1% identity in 406 aa overlap. Contains several membrane spanning domains in N-terminal half; integral membrane protein complement(15777..17261) Neisseria meningitidis Z2491 906039 YP_002341583.1 CDS NMA0021 NC_003116.1 17251 17871 R NMA0021, probable integral membrane protein, len: 206 aa; weak similarity to TR:CAB42042 (EMBL:AL049754) Streptomyces coelicolor spermidine synthase SCH10.33c (554 aa), fasta scores; E(): 0.0013, 25.8% identity in 194 aa overlap. Contains several membrane spanning domains; integral membrane protein complement(17251..17871) Neisseria meningitidis Z2491 906040 YP_002341584.1 CDS NMA0022 NC_003116.1 18070 18447 R NMA0022, transposase for IS1016, len: 125 aa; 91.3% identity to TR:AAD31037 (EMBL:AF142582) N.g. MAFI (104 aa), and highly similar to part of TR:Q48234 (EMBL:X59756) Haemophilus influenzae insertion sequence IS1016-V6 (191 aa), fasta scores; E(): 2e-12, 67.9% identity in 53 aa overlap; IS1016 transposase complement(18070..18447) Neisseria meningitidis Z2491 906041 YP_002341585.1 CDS NMA0023 NC_003116.1 18500 18829 D NMA0023, unknown, len: 109 aa; hypothetical protein 18500..18829 Neisseria meningitidis Z2491 906042 YP_002341586.1 CDS NMA0024 NC_003116.1 18983 19198 D NMA0024, unknown, len: 71 aa; similar to NMA0323,fasta scores; E(): 5.6e-11, 46.4% identity in 69 aa overlap; hypothetical protein 18983..19198 Neisseria meningitidis Z2491 906043 YP_002341587.1 CDS NMA0025 NC_003116.1 19388 19927 R NMA0025, unknown, len: 179 aa; hypothetical protein complement(19388..19927) Neisseria meningitidis Z2491 906044 YP_002341588.1 CDS NMA0027 NC_003116.1 20284 22491 R NMA0027, uvrD, probable DNA helicase II, len 735 aa; similar to e.g. UVRD_ECOLI DNA helicase II (EC 3.6.1.-) (720 aa), fasta scores; E(): 0, 48.0% identity in 736 aa overlap. Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase, and PS00017 ATP/GTP-binding site motif A (P-loop); DNA helicase II complement(20284..22491) Neisseria meningitidis Z2491 906045 YP_002341589.1 CDS NMA0028 NC_003116.1 22675 23322 D NMA0028, unknown, len: 215 aa; similar to hypothetical proteins e.g. YBGJ_HAEIN HI1731 (213 aa),fasta scores; E(): 0, 59.0% identity in 212 aa overlap; hypothetical protein 22675..23322 Neisseria meningitidis Z2491 906046 YP_002341590.1 CDS NMA0029 NC_003116.1 23319 24248 D NMA0029, unknown, len: 309 aa; similar to hypothetical proteins e.g. YBGK_HAEIN HI1730 (309 aa),fasta scores; E(): 0, 59.6% identity in 307 aa overlap. Also some similarity to part of DUR1_YEAST urea amidolyase (1835 aa), fasta scores; E(): 2.1e-12, 27.6% identity in 323 aa overlap; hypothetical protein 23319..24248 Neisseria meningitidis Z2491 906047 YP_002341591.1 CDS NMA0030 NC_003116.1 24235 24972 D NMA0030, unknown, len: 245 aa; similar to hypothetical proteins e.g. YBGL_HAEIN HI1729 (257 aa),fasta scores; E(): 0, 59.6% identity in 245 aa overlap, and to LAMB_EMENI Emericella nidulans lactam utilization protein LAMB (262 aa), fasta scores; E(): 3.3e-13, 39.1% identity in 128 aa overlap; LamB/YcsF family protein 24235..24972 Neisseria meningitidis Z2491 906048 YP_002341592.1 CDS NMA0031 NC_003116.1 25101 26294 D NMA0031, probable transmembrane transport protein,len: 397 aa; similar to many diverse transport proteins e.g. BRNQ_HAEIN branched-chain amino acid transport system carrier protein (436 aa), fasta scores; E(): 6.7e-06,23.7% identity in 371 aa overlap, and TYRP_HAEIN tyrosine-specific transport protein 1 (400 aa), fasta scores; E(): 0.25, 24.9% identity in 213 aa overlap; transmembrane transport protein 25101..26294 Neisseria meningitidis Z2491 906049 YP_002341593.1 CDS NMA0032 NC_003116.1 26402 27094 D NMA0032, unknown, len: 230 aa; similar to NMA0403,fasta scores; E(): 0, 53.5% identity in 230 aa overlap; hypothetical protein 26402..27094 Neisseria meningitidis Z2491 906050 YP_002341594.1 CDS NMA0033 NC_003116.1 27359 28324 D NMA0033, probable transposase for IS1655, len: 321 aa; similar to many e.g. TRA4_BACFR transposase for insertion sequence element IS4351 (326 aa), fasta scores; E(): 0, 41.6% identity in 310 aa overlap. Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family, score 373.60, E-value 2e-108; transposase for IS1655 27359..28324 Neisseria meningitidis Z2491 906051 YP_002341595.1 CDS NMA0035 NC_003116.1 28626 31316 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(28626..31316) Neisseria meningitidis Z2491 906052 YP_002341596.1 CDS NMA0036 NC_003116.1 31491 31826 R NMA0036, unknown, len: 111 aa; hypothetical protein complement(31491..31826) Neisseria meningitidis Z2491 906053 YP_002341597.1 CDS NMA0037 NC_003116.1 32080 32553 R NMA0037, unknown, len: 157 aa; hypothetical protein complement(32080..32553) Neisseria meningitidis Z2491 906054 YP_002341598.1 CDS NMA0038 NC_003116.1 32606 32887 R NMA0038, unknown, len: 93 aa; highly similar to NMA2116, fasta scores; E(): 0, 88.2% identity in 93 aa overlap; hypothetical protein complement(32606..32887) Neisseria meningitidis Z2491 906055 YP_002341599.1 CDS NMA0039 NC_003116.1 32974 33297 R NMA0039, unknown, len: 107 aa; hypothetical protein complement(32974..33297) Neisseria meningitidis Z2491 906056 YP_002341600.1 CDS pyrD NC_003116.1 33630 34637 R catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 complement(33630..34637) Neisseria meningitidis Z2491 906059 YP_002341601.1 CDS acpP NC_003116.1 34869 35105 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 34869..35105 Neisseria meningitidis Z2491 906060 YP_002341602.1 CDS fabF NC_003116.1 35272 36519 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 35272..36519 Neisseria meningitidis Z2491 906061 YP_002341603.1 CDS NMA0046 NC_003116.1 36762 37718 R NMA0046, probable transmembrane transport protein,len: 318 aa; similar to members of the SBF family e.g. TR:O34524 (EMBL:AF027868) B. subtilis transporter YOCS (321 aa), fasta scores; E(): 0, 37.7% identity in 305 aa overlap, and NTCI_HUMAN ileal sodium/bile acid cotransporter (348 aa), fasta scores; E(): 2.4e-13, 27.8% identity in 252 aa overlap; transmembrane transport protein complement(36762..37718) Neisseria meningitidis Z2491 906062 YP_002341604.1 CDS NMA0047 NC_003116.1 38144 39361 D NMA0047, probable transmembrane transport protein,len: 405 aa; similar to e.g. YHJX_ECOLI hypothetical protein (402 aa), fasta scores; E(): 7.9e-17, 24.7% identity in 397 aa overlap, and TR:Q51330 (EMBL:U40075) Oxalobacter formigenes oxalate:formate antiport protein (418 aa), fasta scores; E(): 1.5e-16, 26.8% identity in 377 aa overlap; transmembrane transport protein 38144..39361 Neisseria meningitidis Z2491 906063 YP_002341605.1 CDS NMA0048 NC_003116.1 39717 40850 D NMA0048, pglA, glycosyltransferase, len: 377 aa; almost identical to TR:O87893 (EMBL:U73942) N.m. glycosyltransferase involved in pilin glycosylation (376 aa), fasta scores; E(): 0, 98.9% identity in 377 aa overlap. Also similar to many others e.g. TR:Q53982 (EMBL:M96064) Shigella dysenteriae RFP protein (377 aa),fasta scores; E(): 0, 48.5% identity in 377 aa overlap,Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, and (g)14 tract at aa 246; glycosyltransferase 39717..40850 Neisseria meningitidis Z2491 906064 YP_002341606.1 CDS NMA0049 NC_003116.1 41790 42641 R NMA0049, probable RNA polymerase sigma factor, len: 283 aa; similar to many members of the sigma-54 family e.g. RP54_ALCEU RNA polymerase sigma-54 factor (493 aa),fasta scores; E(): 4.7e-11, 31.4% identity in 303 aa overlap, and RP54_ECOLI RNA polymerase sigma-54 factor (477 aa), fasta scores; E(): 0.034, 32.2% identity in 273 aa overlap. Contains PS00718 Sigma-54 factors family signature 2; RNA polymerase sigma factor complement(41790..42641) Neisseria meningitidis Z2491 906065 YP_002341607.1 CDS NMA0050 NC_003116.1 42989 44503 D NMA0050, katA, catalase, len: 504 aa; highly similar to many e.g. CATA_HAEIN catalase (EC 1.11.1.6) (508 aa), fasta scores; E(): 0, 91.7% identity in 507 aa overlap. Contains Pfam match to entry PF00199 catalase,Catalase, PS00438 Catalase proximal active site signature, and PS00437 Catalase proximal heme-ligand signature; catalase 42989..44503 Neisseria meningitidis Z2491 906066 YP_002341608.1 CDS NMA0052 NC_003116.1 44988 45554 D NMA0052, probable integral membrane protein, len: 188 aa; similar to hypothetical proteins belonging to the UPF0059 family e.g. YEBN_ECOLI (206 aa), fasta scores; E(): 1.5e-29, 48.9% identity in 186 aa overlap; integral membrane protein 44988..45554 Neisseria meningitidis Z2491 906068 YP_002341609.1 CDS NMA0054 NC_003116.1 45987 48023 R NMA0054, prlC, probable oligopeptidase A, len: 678 aa; similar to many e.g. OPDA_ECOLI oligopeptidase A (EC 3.4.24.70) (680 aa), fasta scores; E(): 0, 49.9% identity in 679 aa overlap. Contains Pfam match to entry PF01432 Peptidase_M3, Peptidase family M3, and PS00017 ATP/GTP-binding site motif A (P-loop); oligopeptidase A complement(45987..48023) Neisseria meningitidis Z2491 906070 YP_002341610.1 CDS NMA0055 NC_003116.1 48111 49097 R NMA0055, probable integral membrane protein, len: 328 aa; integral membrane protein complement(48111..49097) Neisseria meningitidis Z2491 906071 YP_002341611.1 CDS gyrB NC_003116.1 49253 51643 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 49253..51643 Neisseria meningitidis Z2491 906072 YP_002341612.1 CDS NMA0057 NC_003116.1 51962 53281 D NMA0057, sdaA, probable L-serine dehydratase, len: 439 aa; similar to many e.g. SDHL_STRCO L-serine dehydratase (EC 4.3.1.17) (455 aa), fasta scores; E(): 0,51.7% identity in 433 aa overlap; L-serine dehydratase 51962..53281 Neisseria meningitidis Z2491 906073 YP_002341613.1 CDS NMA0060 NC_003116.1 54687 56663 R NMA0060, probable transmembrane transport protein,len; 658 aa; similar to e.g. KEFB_ECOLI glutathione-regulated potassium-efflux system protein KEFB (601 aa), fasta scores; E(): 0, 33.6% identity in 563 aa overlap, Contains PS00213 Lipocalin signature; transmembrane transport protein complement(54687..56663) Neisseria meningitidis Z2491 906075 YP_002341614.1 CDS NMA0061 NC_003116.1 56812 57651 D NMA0061, probable ferredoxin, len: 279 aa; similar to e.g. YDGM_ECOLI ferredoxin-like protein (192 aa), fasta scores; E(): 2.7e-23, 52.9% identity in 153 aa overlap. Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains., and 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; ferredoxin 56812..57651 Neisseria meningitidis Z2491 906076 YP_002341615.1 CDS NMA0062 NC_003116.1 57851 58882 D NMA0062, gapA, glyceraldehyde 3-phosphate dehydrogenase, len: 343 aa; similar to many e.g. G3PP_ALCEU glyceraldehyde 3-phosphate dehydrogenase,plasmid (EC 1.1.1.2842) (336 aa), fasta scores; E(): 0,67.4% identity in 331 aa overlap. Contains Pfam match to entry PF00044 gpdh, glyceraldehyde 3-phosphate dehydrogenases, and PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. Also similar to gapC, NMA0246,fasta scores; E(): 0, 50.7% identity in 341 aa overlap; glyceraldehyde 3-phosphate dehydrogenase 57851..58882 Neisseria meningitidis Z2491 906077 YP_002341616.1 CDS aat NC_003116.1 59138 59863 R leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase complement(59138..59863) Neisseria meningitidis Z2491 906078 YP_002341617.1 CDS NMA0064 NC_003116.1 59933 60367 R NMA0064, fur, ferric uptake regulation protein,len: 144 aa; almost identical to FUR_NEIME ferric uptake regulation protein (144 aa), fasta scores; E(): 0, 99.3% identity in 144 aa overlap. Contains Pfam match to entry PF01475 FUR, Ferric uptake regulator family E-value 1.3e-68; ferric uptake regulation protein complement(59933..60367) Neisseria meningitidis Z2491 906079 YP_002341618.1 CDS NMA0065 NC_003116.1 60586 60963 D NMA0065, probable lipoprotein, len: 125 aa; similar to hypothetical proteins e.g. SMPA_ECOLI small protein A (113 aa), fasta scores; E(): 1.5e-06, 39.8% identity in 103 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 60586..60963 Neisseria meningitidis Z2491 906080 YP_002341619.1 CDS dapB NC_003116.1 60973 61782 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 60973..61782 Neisseria meningitidis Z2491 906081 YP_002341620.1 CDS NMA0067 NC_003116.1 62042 62341 R NMA0067, unknown, len: 99 aa; hypothetical protein complement(62042..62341) Neisseria meningitidis Z2491 906082 YP_002341621.1 CDS lpxB NC_003116.1 62708 63862 R catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase complement(62708..63862) Neisseria meningitidis Z2491 906084 YP_002341622.1 CDS NMA0070 NC_003116.1 63928 64920 R NMA0070, rluC, probable ribosomal large subunit pseudouridine synthase C, len: 330 aa; similar to many e.g. RLUC_ECOLI ribosomal large subunit pseudouridine synthase C (EC 4.2.1.70) (319 aa), fasta scores; E(): 0,53.7% identity in 311 aa overlap. Contains Pfam match to entry PF00849 YABO, Hypothetical yabO/yceC/sfhB family, and PS01129 Hypothetical yabO/yceC/sfhB family signature; ribosomal large subunit pseudouridine synthase C complement(63928..64920) Neisseria meningitidis Z2491 906085 YP_002341623.1 CDS NMA0071 NC_003116.1 65414 68173 D NMA0071, rne, probable ribonuclease E, len: 919 aa; similar to e.g. RNE_ECOLI ribonuclease E (EC 3.1.4.-) (1061 aa), fasta scores; E(): 0, 44.3% identity in 979 aa overlap. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain; ribonuclease E 65414..68173 Neisseria meningitidis Z2491 906086 YP_002341624.1 CDS pdxA NC_003116.1 68960 69949 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(68960..69949) Neisseria meningitidis Z2491 906087 YP_002341625.1 CDS NMA0073 NC_003116.1 70109 71536 D NMA0073, probable amino-acid transport protein,len: 475 aa; similar to e.g. ALST_BACSU amino acid carrier protein ALST (465 aa), fasta scores; E(): 0, 49.3% identity in 469 aa overlap, and DAGA_ALTHA Na(+)-linked D-alanine glycine permease (542 aa), fasta scores; E(): 0,44.2% identity in 303 aa overlap. Contains Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family, PS00873 Sodium:alanine symporter family signature, and (cgc)5 sequence at aa 291; amino-acid transport protein 70109..71536 Neisseria meningitidis Z2491 906088 YP_002341626.1 CDS gidA NC_003116.1 71870 73756 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 71870..73756 Neisseria meningitidis Z2491 906089 YP_002341627.1 CDS rnhB NC_003116.1 73825 74409 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 73825..74409 Neisseria meningitidis Z2491 906090 YP_002341628.1 CDS NMA0076 NC_003116.1 75357 76130 R NMA0076, parA family protein, len: 257 aa; similar to many e.g. SOJ_BACSU SOJ protein (253 aa), fasta scores; E(): 0, 55.6% identity in 248 aa overlap. Contains Pfam match to entry PF00991 ParA, ParA family ATPase; parA family protein complement(75357..76130) Neisseria meningitidis Z2491 906091 YP_002341629.1 CDS gidB NC_003116.1 76229 76852 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(76229..76852) Neisseria meningitidis Z2491 906092 YP_002341630.1 CDS NMA0078 NC_003116.1 76948 77433 R NMA0078, probable integral membrane protein, len: 161 aa. Contains four probable transmembrane domains; integral membrane protein complement(76948..77433) Neisseria meningitidis Z2491 906093 YP_002341631.1 CDS NMA0079 NC_003116.1 77843 78970 D NMA0079, probable integral membrane protein, len: 375 aa; similar to hypothetical proteins e.g. YEEA_ECOLI (352 aa), fasta scores; E(): 1.9e-20, 27.9% identity in 348 aa overlap; integral membrane protein 77843..78970 Neisseria meningitidis Z2491 906094 YP_002341632.1 CDS frr NC_003116.1 79151 79708 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 79151..79708 Neisseria meningitidis Z2491 906095 YP_002341633.1 CDS NMA0081 NC_003116.1 79764 80510 D NMA0081, uppS, UDP diphosphate synthase, len: 248 aa; similar to e.g. UPPS_ECOLI UDP PYROPHOSPHATE SYNTHETASE (EC 2.5.1.31) (252 aa), fasta scores; E(): 0, 51.6% identity in 246 aa overlap, and to TR:O82827 (EMBL:AB004319) Micrococcus luteus UDP diphosphate synthase (249 aa), fasta scores; E(): 0, 45.4% identity in 229 aa overlap. Contains Pfam match to entry PF01255 UPF0015, Uncharacterized protein family UPF0015, score 372.10, E-value 5.6e-108, and PS01066 Uncharacterized protein family UPF0015 signature; UDP diphosphate synthase 79764..80510 Neisseria meningitidis Z2491 906096 YP_002341634.1 CDS NMA0082 NC_003116.1 80513 81310 D NMA0082, cdsA, probable phosphatidate cytidylyltransferase, len: 265 aa; similar to many e.g. CDSA_PSEAE phosphatidate cytidylyltransferase (EC 2.7.7.41) (271 aa), fasta scores; E(): 0, 44.2% identity in 269 aa overlap. Contains Pfam match to entry PF01148 Cytidylyltrans, Phosphatidate cytidylyltransferase, and PS01315 Phosphatidate cytidylyltransferase signature; phosphatidate cytidylyltransferase 80513..81310 Neisseria meningitidis Z2491 906097 YP_002341635.1 CDS dxr NC_003116.1 81366 82550 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 81366..82550 Neisseria meningitidis Z2491 906098 YP_002341636.1 CDS NMA0084 NC_003116.1 82585 83925 D NMA0084, probable integral membrane protein, len: 446 aa; similar to many hypothetical proteins e.g. YAEL_ECOLI (450 aa), fasta scores; E(): 0, 38.4% identity in 456 aa overlap. Contains 2x Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF), and PS00142 Neutral zinc metallopeptidases, zinc-binding region signature; integral membrane protein 82585..83925 Neisseria meningitidis Z2491 906099 YP_002341637.1 CDS NMA0085 NC_003116.1 83982 86375 D NMA0085, omp85, outer membrane protein OMP85, len: 797 aa; almost identical to TR:O30912 (EMBL:AF021245) N.m. strain HH outer membrane protein OMP85 (797 aa), fasta scores; E(): 0, 99.6% identity in 797 aa overlap, and similar to e.g. D152_HAEIN protective surface antigen D15 precursor (795 aa), fasta scores; E(): 0, 31.6% identity in 813 aa overlap. Contains Pfam match to entry PF01103 Bac_surface_Ag, Bacterial surface antigen, PS00017 ATP/GTP-binding site motif A (P-loop), and N-terminal signal sequence; outer membrane protein OMP85 83982..86375 Neisseria meningitidis Z2491 906100 YP_002341638.1 CDS NMA0086 NC_003116.1 86441 86941 D NMA0086, outer membrane protein, len: 166 aa; similar to e.g. OMPH_YEREN cationic 19 kd outer membrane protein precursor (164 aa), fasta scores; E(): 1.1e-05, 25.0% identity in 164 aa overlap, and HLPA_ECOLI histone-like protein HLP-1 precursor (161 aa), fasta scores; E(): 0.00038, 26.3% identity in 167 aa overlap. Contains N-terminal signal sequence; hypothetical protein 86441..86941 Neisseria meningitidis Z2491 906101 YP_002341639.1 CDS lpxD NC_003116.1 86974 88017 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 86974..88017 Neisseria meningitidis Z2491 906102 YP_002341640.1 CDS fabZ NC_003116.1 88053 88502 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 88053..88502 Neisseria meningitidis Z2491 906103 YP_002341641.1 CDS NMA0089 NC_003116.1 88813 89493 D NMA0089, unknown, len; 226 aa; hypothetical protein 88813..89493 Neisseria meningitidis Z2491 906104 YP_002341642.1 CDS lpxA NC_003116.1 89536 90312 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 89536..90312 Neisseria meningitidis Z2491 906105 YP_002341643.1 CDS NMA0091 NC_003116.1 90669 92060 D NMA0091, probable amino-acid transporter, len: 463 aa; similar to members of the sodium:alanine symporter family e.g. Y883_HAEIN P44917 hypothetical protein HI0883 (456 aa), fasta scores; E(): 0, 52.6% identity in 454 aa overlap, and DAGA_ALTHA P30144 Na(+)-linked D-alanine glycine permease (542 aa), fasta scores; E(): 0, 36.1% identity in 540 aa overlap. Contains Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family, and PS00873 Sodium:alanine symporter family signature E-value 6e-162; amino-acid transporter 90669..92060 Neisseria meningitidis Z2491 906106 YP_002341644.1 CDS dadA NC_003116.1 92139 93395 D catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 92139..93395 Neisseria meningitidis Z2491 906107 YP_002341645.1 CDS NMA0093 NC_003116.1 93576 94385 D NMA0093, probable integral membrane protein, len: 269 aa; similar to hypothetical proteins e.g. YGIE_ECOLI P24198 (257 aa), fasta scores; E(): 5.8e-28, 36.8% identity in 261 aa overlap; zinc transporter ZupT 93576..94385 Neisseria meningitidis Z2491 906108 YP_002341646.1 CDS valS NC_003116.1 94482 97319 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 94482..97319 Neisseria meningitidis Z2491 906109 YP_002341647.1 CDS NMA0095 NC_003116.1 97474 97629 D NMA0095, unknown, len: 51 aa; hypothetical protein 97474..97629 Neisseria meningitidis Z2491 906110 YP_002341648.1 CDS NMA0096 NC_003116.1 97690 98079 R NMA0096, unknown, len: 129 aa; similar to NMA1028,fasta scores; E(): 1.7e-19, 45.2% identity in 126 aa overlap, NMA1027, fasta scores; E(): 1.6e-12, 36.4% identity in 118 aa overlap, NMA1026, fasta scores; E(): 5.4e-10, 30.4% identity in 125 aa overlap, and the N-terminus of NMA1636, fasta scores; E(): 1.4e-06, 44.3% identity in 61 aa overlap; hypothetical protein complement(97690..98079) Neisseria meningitidis Z2491 906111 YP_002341649.1 CDS NMA0098 NC_003116.1 98653 99573 R NMA0098, oxyR, hydrogen peroxide-inducible genes activator, len: 306 aa; similar to e.g. OXYR_ECOLI P11721 hydrogen peroxide-inducible genes activator (305 aa), fasta scores; E(): 0, 37.5% identity in 280 aa overlap. Contains Pfam match to entry PF00126 HTH_1,Bacterial regulatory helix-turn-helix protein, lysR family, and PS00044 Bacterial regulatory proteins, lysR family signature; hydrogen peroxide-inducible genes activator complement(98653..99573) Neisseria meningitidis Z2491 906112 YP_002341650.1 CDS NMA0099 NC_003116.1 99577 99840 R works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(99577..99840) Neisseria meningitidis Z2491 906113 YP_002341651.1 CDS NMA0100 NC_003116.1 99844 100659 R NMA0100, minD, probable septum site-determining protein, len: 271 aa; highly similar to e.g. MIND_ECOLI P18197 septum site-determining protein MIND (269 aa),fasta scores; E(): 0, 73.8% identity in 271 aa overlap. Contains Pfam match to entry PF00991 ParA, ParA family ATPase, and PS00017 ATP/GTP-binding site motif A (P-loop) E-value 5.8e-05; septum site-determining protein complement(99844..100659) Neisseria meningitidis Z2491 906114 YP_002341652.1 CDS minC NC_003116.1 100688 101401 R blocks the formation of polar Z-ring septums; septum formation inhibitor complement(100688..101401) Neisseria meningitidis Z2491 906115 YP_002341653.1 CDS rplQ NC_003116.1 101548 101916 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(101548..101916) Neisseria meningitidis Z2491 906116 YP_002341654.1 CDS rpoA NC_003116.1 101940 102926 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(101940..102926) Neisseria meningitidis Z2491 906117 YP_002341655.1 CDS rpsD NC_003116.1 102952 103572 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(102952..103572) Neisseria meningitidis Z2491 906118 YP_002341656.1 CDS rpsK NC_003116.1 103592 103987 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(103592..103987) Neisseria meningitidis Z2491 906119 YP_002341657.1 CDS rpsM NC_003116.1 104007 104369 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(104007..104369) Neisseria meningitidis Z2491 906120 YP_002341658.1 CDS rpmJ NC_003116.1 104435 104548 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(104435..104548) Neisseria meningitidis Z2491 906121 YP_002341659.1 CDS infA NC_003116.1 104569 104787 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(104569..104787) Neisseria meningitidis Z2491 906122 YP_002341660.1 CDS secY NC_003116.1 104792 106102 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(104792..106102) Neisseria meningitidis Z2491 906123 YP_002341661.1 CDS rplO NC_003116.1 106114 106548 R late assembly protein; 50S ribosomal protein L15 complement(106114..106548) Neisseria meningitidis Z2491 906124 YP_002341662.1 CDS rpmD NC_003116.1 106550 106735 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(106550..106735) Neisseria meningitidis Z2491 906125 YP_002341663.1 CDS rpsE NC_003116.1 106728 107246 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(106728..107246) Neisseria meningitidis Z2491 906126 YP_002341664.1 CDS rplR NC_003116.1 107265 107618 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(107265..107618) Neisseria meningitidis Z2491 906127 YP_002341665.1 CDS rplF NC_003116.1 107632 108165 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(107632..108165) Neisseria meningitidis Z2491 906128 YP_002341666.1 CDS rpsH NC_003116.1 108179 108571 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(108179..108571) Neisseria meningitidis Z2491 906129 YP_002341667.1 CDS rpsN NC_003116.1 108587 108892 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(108587..108892) Neisseria meningitidis Z2491 906130 YP_002341668.1 CDS rplE NC_003116.1 108895 109434 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(108895..109434) Neisseria meningitidis Z2491 906131 YP_002341669.1 CDS rplX NC_003116.1 109444 109767 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(109444..109767) Neisseria meningitidis Z2491 906132 YP_002341670.1 CDS rplN NC_003116.1 109779 110147 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(109779..110147) Neisseria meningitidis Z2491 906133 YP_002341671.1 CDS rpsQ NC_003116.1 110369 110632 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(110369..110632) Neisseria meningitidis Z2491 906134 YP_002341672.1 CDS rpmC NC_003116.1 110632 110823 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(110632..110823) Neisseria meningitidis Z2491 906135 YP_002341673.1 CDS rplP NC_003116.1 110823 111239 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(110823..111239) Neisseria meningitidis Z2491 906136 YP_002341674.1 CDS rpsC NC_003116.1 111223 111915 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(111223..111915) Neisseria meningitidis Z2491 906137 YP_002341675.1 CDS rplV NC_003116.1 111925 112254 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(111925..112254) Neisseria meningitidis Z2491 906138 YP_002341676.1 CDS rpsS NC_003116.1 112263 112541 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(112263..112541) Neisseria meningitidis Z2491 906139 YP_002341677.1 CDS rplB NC_003116.1 112548 113381 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(112548..113381) Neisseria meningitidis Z2491 906140 YP_002341678.1 CDS rplW NC_003116.1 113387 113707 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(113387..113707) Neisseria meningitidis Z2491 906141 YP_002341679.1 CDS rplD NC_003116.1 113698 114318 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(113698..114318) Neisseria meningitidis Z2491 906142 YP_002341680.1 CDS rplC NC_003116.1 114318 114962 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(114318..114962) Neisseria meningitidis Z2491 906143 YP_002341681.1 CDS NMA0131 NC_003116.1 115181 115864 R NMA0131, ATP/GTP binding protein, len: 227 aa; some similarity in ATP/GTP binding domain to TR:Q9ZL99 (EMBL:AE001499) Helicobacter pylori J99 hypothetical protein (404 aa), fasta scores; E(): 0.00018, 37.3% identity in 102 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Also similar to upstream gene NMA0132 (43.2% identity in 229 aa overlap); hypothetical protein complement(115181..115864) Neisseria meningitidis Z2491 906144 YP_002341682.1 CDS NMA0132 NC_003116.1 115873 116928 R NMA0132, ATP/GTP binding protein, len: 351 aa; similar to downstream gene NMA0131 (43.2% identity in 229 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein complement(115873..116928) Neisseria meningitidis Z2491 906145 YP_002341683.1 CDS NMA0132A NC_003116.1 116903 117163 R NMA0132A, unknown, len: 86 aa; contains G(9) homopolymeric tract; hypothetical protein complement(116903..117163) Neisseria meningitidis Z2491 906147 YP_002341684.1 CDS rpsJ NC_003116.1 117216 117527 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(117216..117527) Neisseria meningitidis Z2491 906148 YP_002341685.1 CDS tufA1 NC_003116.1 117545 118729 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(117545..118729) Neisseria meningitidis Z2491 906149 YP_002341686.1 CDS fusA NC_003116.1 118817 120922 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(118817..120922) Neisseria meningitidis Z2491 906150 YP_002341687.1 CDS rpsG NC_003116.1 120941 121411 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(120941..121411) Neisseria meningitidis Z2491 906151 YP_002341688.1 CDS rpsL NC_003116.1 121529 121900 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(121529..121900) Neisseria meningitidis Z2491 906152 YP_002341689.1 CDS NMA0138 NC_003116.1 122079 122228 R NMA0138, unknown, len: 49 aa; similar to the extreme C-terminus of Moraxella catarrhalis TR:O85087 (EMBL:AF043131) hypothetical 60.4 kd protein (538 aa),fasta scores; E(): 2.6e-07, 34.7% identity in 49 aa overlap. Also similar to the C-terminus of NMA1678 (60.9% identity in 46 aa overlap), NMA0476 (43.5% identity in 46 aa overlap), and NMA2174 (33.3% identity in 48 aa overlap); hypothetical protein complement(122079..122228) Neisseria meningitidis Z2491 906153 YP_002341690.1 CDS NMA0139 NC_003116.1 122225 122482 R NMA0139, periplasmic protein, len: 85 aa; contains N-terminal signal sequence; hypothetical protein complement(122225..122482) Neisseria meningitidis Z2491 906154 YP_002341691.1 CDS NMA0140 NC_003116.1 122531 122680 R NMA0140, unknown, len: 49 aa; hypothetical protein complement(122531..122680) Neisseria meningitidis Z2491 906155 YP_002341692.1 CDS rpoC NC_003116.1 122773 126948 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(122773..126948) Neisseria meningitidis Z2491 906156 YP_002341693.1 CDS rpoB NC_003116.1 127100 131278 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(127100..131278) Neisseria meningitidis Z2491 906157 YP_002341694.1 CDS rplL NC_003116.1 131469 131840 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(131469..131840) Neisseria meningitidis Z2491 906158 YP_002341695.1 CDS rplJ NC_003116.1 131898 132398 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(131898..132398) Neisseria meningitidis Z2491 906159 YP_002341696.1 CDS rplA NC_003116.1 132628 133323 R in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 complement(132628..133323) Neisseria meningitidis Z2491 906160 YP_002341697.1 CDS rplK NC_003116.1 133323 133757 R binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(133323..133757) Neisseria meningitidis Z2491 906161 YP_002341698.1 CDS nusG NC_003116.1 133858 134394 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(133858..134394) Neisseria meningitidis Z2491 906162 YP_002341699.1 CDS secE NC_003116.1 134396 134674 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(134396..134674) Neisseria meningitidis Z2491 906163 YP_002341700.1 CDS tufA2 NC_003116.1 134871 136055 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(134871..136055) Neisseria meningitidis Z2491 906164 YP_002341701.1 CDS NMA0150 NC_003116.1 136472 136723 R NMA0150, probable ferredoxin, len: 83 aa; similar to e.g. FER_CHRVI fP00208 erredoxin (82 aa), fasta scores; E(): 1.7e-20, 70.5% identity in 78 aa overlap. Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains, and PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; ferredoxin complement(136472..136723) Neisseria meningitidis Z2491 906165 YP_002341702.1 CDS NMA0151 NC_003116.1 136846 137415 R NMA0151, DNA methylase, len: 189 aa; similar to hypothetical proteins containing methylase signatures e.g. YHHF_ECOLI P10120 (198 aa), fasta scores; E(): 3.1e-19, 38.2% identity in 186 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00092 N-6 Adenine-specific DNA methylases signature; DNA methylase complement(136846..137415) Neisseria meningitidis Z2491 906166 YP_002341703.1 CDS NMA0153 NC_003116.1 137504 137884 R NMA0153, unknown, len: 126 aa; similar to TR:Q51849 (EMBL:U39043) Pasteurella haemolytica hypothetical protein (100 aa), fasta scores; E(): 1.2e-05, 35.7% identity in 84 aa overlap. Contains Pfam match to entry PF01381 HTH_3,Helix-turn-helix; hypothetical protein complement(137504..137884) Neisseria meningitidis Z2491 906167 YP_002341704.1 CDS NMA0154 NC_003116.1 138003 138554 D NMA0154, probable integral membrane protein, len: 183 aa; integral membrane protein 138003..138554 Neisseria meningitidis Z2491 906168 YP_002341705.1 CDS NMA0155 NC_003116.1 138574 139269 D NMA0155, unknown, len: 231 aa; hypothetical protein 138574..139269 Neisseria meningitidis Z2491 906169 YP_002341706.1 CDS topA NC_003116.1 139342 141648 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity; DNA topoisomerase I complement(139342..141648) Neisseria meningitidis Z2491 906170 YP_002341707.1 CDS NMA0157 NC_003116.1 141720 142181 R NMA0157, unknown, len: 153 aa; some similarity to SMG_ECOLI P30853 SMG protein (157 aa), fasta scores; E(): 1.1e-05, 27.3% identity in 132 aa overlap; hypothetical protein complement(141720..142181) Neisseria meningitidis Z2491 906171 YP_002341708.1 CDS NMA0158 NC_003116.1 142207 143394 R NMA0158, dprA, DprA homolog, len: 395 aa; similar to SMF_HAEIN P43862 SMF protein (DNA processing chain A) thought to be involved in DNA uptake (373 aa), fasta scores; E(): 1.9e-29, 40.1% identity in 324 aa overlap, and to hypothetical proteins e.g. SMF_ECOLI P30852 SMF protein (374 aa), fasta scores; E(): 2.3e-27, 37.2% identity in 360 aa overlap; DprA-like protein complement(142207..143394) Neisseria meningitidis Z2491 906172 YP_002341709.1 CDS NMA0159 NC_003116.1 143485 144762 R NMA0159, probable two-component trancriptional regulator, len: 425 aa; similar to many e.g. NTRX_AZOCA Q04849 nitrogen assimilation regulatory protein NTRX (454 aa), fasta scores; E(): 4.5e-15, 34.9% identity in 458 aa overlap, and HYDG_ECOLI P14375 transcriptional regulatory protein HYDG (441 aa), fasta scores; E(): 1.6e-14, 29.0% identity in 448 aa overlap. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain, and Pfam match to entry PF00158 sigma54, Sigma-54 transcription factors; two-component transcriptional regulator complement(143485..144762) Neisseria meningitidis Z2491 906173 YP_002341710.1 CDS NMA0160 NC_003116.1 144755 146875 R NMA0160, probable two-component sensor, len: 706 aa; similar to many e.g. NTRY_AZOCA Q04850 nitrogen regulation protein NTRY (EC 2.7.3.-) (771 aa), fasta scores; E(): 0, 29.8% identity in 721 aa overlap, and ATOS_ECOLI Q06067 sensor protein ATOS (EC 2.7.3.-) (608 aa), fasta scores; E(): 2.4e-16, 25.3% identity in 439 aa overlap. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins and Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain, and four transmembrane domains; two-component sensor complement(144755..146875) Neisseria meningitidis Z2491 906174 YP_002341711.1 CDS NMA0161 NC_003116.1 146875 147474 R NMA0161, unknown, len: 199 aa; hypothetical protein complement(146875..147474) Neisseria meningitidis Z2491 906175 YP_002341712.1 CDS NMA0162 NC_003116.1 147440 148699 R NMA0162, SUN homolog, len: 419 aa; similar to many e.g. SUN_ECOLI P36929 SUN protein (FMU protein) (429 aa),fasta scores; E(): 0, 41.2% identity in 427 aa overlap. Contains Pfam match to entry PF01189 Nol1_Nop2_Sun,NOL1/NOP2/sun family. Also similar to NMA1563 (29.9% identity in 371 aa overlap); SUN-like protein complement(147440..148699) Neisseria meningitidis Z2491 906176 YP_002341713.1 CDS NMA0163 NC_003116.1 148778 149704 R NMA0163, fmt, methionyl-tRNA formyltransferase,len: 308 aa; similar to many e.g. FMT_ECOLI P23882 methionyl-tRNA formyltransferase (EC 2.1.2.9) (314 aa),fasta scores; E(): 0, 51.5% identity in 303 aa overlap. Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase; methionyl-tRNA formyltransferase complement(148778..149704) Neisseria meningitidis Z2491 906177 YP_002341714.1 CDS def NC_003116.1 149791 150294 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(149791..150294) Neisseria meningitidis Z2491 906178 YP_002341715.1 CDS NMA0165 NC_003116.1 150478 151695 D NMA0165, probable periplasmic protein, len: 405 aa; has short segment of similarity (encompassing PFAM domain) to TR:O51302 (EMBL:AE001138) Borrelia burgdorferi hypothetical 44.2 kd protein BB0323 (377 aa), fasta scores; E(): 0.0006, 46.0% identity in 50 aa overlap, and XKDP_BACSU P54335 phage-like element PBSX protein XKDP (235 aa), fasta scores; E(): 0.0083, 50.0% identity in 40 aa overlap. Contains Pfam match to entry PF01476 PG_binding_2, peptidoglycan binding domain and N-terminal signal sequence; hypothetical protein 150478..151695 Neisseria meningitidis Z2491 906179 YP_002341716.1 CDS NMA0166 NC_003116.1 151758 152423 R NMA0166, probable integral membrane protein, len: 211 aa; contains two membrane spanning domains near N-terminus; integral membrane protein complement(151758..152423) Neisseria meningitidis Z2491 906180 YP_002341717.1 CDS pyrI NC_003116.1 152488 152946 R involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase complement(152488..152946) Neisseria meningitidis Z2491 906181 YP_002341718.1 CDS pyrB NC_003116.1 152956 153876 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase complement(152956..153876) Neisseria meningitidis Z2491 906182 YP_002341719.1 CDS NMA0169 NC_003116.1 154112 154954 D NMA0169, unknown, len: 280 aa; some similarity in C-terminus to hypothetical proteins e.g. TR:O07579 (EMBL:Y14082) Bacillus subtilis hypothetical 16.4 kd protein YHDJ (142 aa), fasta scores; E(): 4.6e-06, 29.9% identity in 134 aa overlap, and PHNO_ECOLI P16691 PHNO protein (144 aa), fasta scores; E(): 0.00012, 31.9% identity in 144 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; hypothetical protein 154112..154954 Neisseria meningitidis Z2491 906183 YP_002341720.1 CDS NMA0170 NC_003116.1 154951 155109 D NMA0170, probable lipoprotein, len: 52 aa; contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 154951..155109 Neisseria meningitidis Z2491 906184 YP_002341721.1 CDS NMA0171 NC_003116.1 155236 155955 D NMA0171, unknown, len: 239 aa; similar in part to NMA1084 (54.7% identity in 53 aa overlap), and NMA1073 (40.4% identity in 104 aa overlap); hypothetical protein 155236..155955 Neisseria meningitidis Z2491 906185 YP_002341722.1 CDS NMA0171A NC_003116.1 156030 156266 D NMA0171A, integral membrane protein, len: 78 aa; contains two transmembrane domains; integral membrane protein 156030..156266 Neisseria meningitidis Z2491 906186 YP_002341723.1 CDS NMA0173 NC_003116.1 156247 156905 D NMA0173, unknown, len: 373 aa; some similarity to TR:O53037 (EMBL:U68399) Haemophilus influenzae haemocin processing protein hmcC (198 aa), fasta scores; E(): 2.6e-11, 35.5% identity in 141 aa overlap, and the trhe N-terminus of TR:O87239 (EMBL:AE001272) Lactococcus lactis plasmid pMRC01 predicted cytolysin B transport protein (708 aa), fasta scores; E(): 9.1e-05, 29.0% identity in 138 aa overlap. Also similar to NMA1066 (70.7% identity in 164 aa overlap), and NMA0767 (69.4% identity in 124 aa overlap). Frameshifted at (C)6 tract w.r.t NmC sequence. Coding sequence has been spliced to give intact translation; hypothetical protein join(156247..156339,156339..156905) Neisseria meningitidis Z2491 906188 YP_002341724.1 CDS NMA0174 NC_003116.1 157181 157732 R NMA0174, probable integral membrane protein, len: 183 aa; contains multiple hydrophobic transmembrane domains; integral membrane protein complement(157181..157732) Neisseria meningitidis Z2491 906189 YP_002341725.1 CDS NMA0177 NC_003116.1 158717 160189 D NMA0177, pykA, pyruvate kinase, len: 490 aa; similar to many e.g. KPY2_ECOLI P14178 pyruvate kinase II (EC 2.7.1.40) (PK-2) (479 aa), fasta scores; E(): 0, 49.9% identity in 491 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase; pyruvate kinase 158717..160189 Neisseria meningitidis Z2491 906192 YP_002341726.1 CDS NMA0178 NC_003116.1 160499 161893 D NMA0178, probable outer membrane protein, len: 464 aa; weak similarity to several e.g. TR:Q00754 (EMBL:Q00754) Haemophilus influenzae outer membrane protein P1 precursor (449 aa), fasta scores; E(): 1.2e-07,27.6% identity in 474 aa overlap, TR:O51857 (EMBL:AF006691) Pseudomonas putida plasmid pRE4 outer membrane protein IPBH (492 aa), fasta scores; E(): 1.3e-05, 22.6% identity in 487 aa overlap, and FADL_ECOLI P10384 long-chain fatty acid transport protein precursor (448 aa), fasta scores; E(): 0.00035, 25.2% identity in 428 aa overlap. Contains N-terminal signal sequence; outer membrane protein 160499..161893 Neisseria meningitidis Z2491 906193 YP_002341727.1 CDS NMA0181 NC_003116.1 163021 163218 R NMA0181, unknown, len: 65 aa; hypothetical protein complement(163021..163218) Neisseria meningitidis Z2491 906196 YP_002341728.1 CDS NMA0182 NC_003116.1 163229 164245 R NMA0182, probable lipoprotein, len: 338 aa. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein complement(163229..164245) Neisseria meningitidis Z2491 906197 YP_002341729.1 CDS NMA0183 NC_003116.1 164344 165558 R NMA0183, gltS, sodium/glutamate symport carrier protein, len: 404 aa; similar to many e.g. GLTS_ECOLI P19933 sodium/glutamate symport carrier protein (glutamate permease) (401 aa), fasta scores; E(): 0, 50.9% identity in 393 aa overlap; sodium/glutamate symport carrier protein complement(164344..165558) Neisseria meningitidis Z2491 906198 YP_002341730.1 CDS NMA0184 NC_003116.1 165776 167182 R NMA0184, unknown, len: 468 aa; some similarity to hypothetical proteins e.g. YBEQ_ECOLI P77234 hypothetical 37.3 kd protein in leuS-gltL intergenic region (327 aa),fasta scores E(): 8.4e-07, 29.6% identity in 301 aa overlap; hypothetical protein complement(165776..167182) Neisseria meningitidis Z2491 906199 YP_002341731.1 CDS NMA0185 NC_003116.1 167551 168810 R NMA0185, lipB, capsule polysaccharide modification protein, len: 419 aa; almost identical to LIPB_NEIME Q05014 capsule polysaccharide modification protein (419 aa), fasta scores; E(): 0, 99.8% identity in 419 aa overlap, and similar to e.g. KSS5_ECOLI P42218 capsule polysaccharide export protein KPSS (389 aa), fasta scores; E(): 0, 38.3% identity in 400 aa overlap; capsule polysaccharide modification protein complement(167551..168810) Neisseria meningitidis Z2491 906200 YP_002341732.1 CDS NMA0186 NC_003116.1 168947 171061 R NMA0186, lipA, capsule polysaccharide modification protein, len: 704 aa; almost identical to, but longer than, LIPA_NEIME Q05013 capsule polysaccharide modification protein (400 aa), fasta scores; E(): 0, 97.1% identity in 383 aa overlap, and similar to e.g. KSC5_ECOLI P42217 capsule polysaccharide export protein KPSC (675 aa), fasta scores; E(): 0, 48.9% identity in 687 aa overlap. Contains PS00214 Cytosolic fatty-acid binding proteins signature; capsule polysaccharide modification protein complement(168947..171061) Neisseria meningitidis Z2491 906201 YP_002341733.1 CDS NMA0187 NC_003116.1 171085 171639 R NMA0187, rfbC2, dTDP-4-dehydrorhamnose 3,5-epimerase, len: 184 aa; almost identical to TR:Q51155 (EMBL:L09189) N. meningitidis B1940 rfbC (333 aa), fasta scores; E(): 0, 94.5% identity in 181 aa overlap, and similar to many e.g. RFBC_NEIGO P37763 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (328 aa), fasta scores; E(): 0, 83.5% identity in 176 aa overlap. Contains Pfam match to entry PF00908 dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. Also highly similar to rfbC, NMA0206 (98.3% identity in 181 aa overlap); dTDP-D-glucose 4,6-dehydratase complement(171085..171639) Neisseria meningitidis Z2491 906202 YP_002341734.1 CDS NMA0188 NC_003116.1 171678 172544 R NMA0188, rfbA2, glucose-1-phosphate thymidylyltransferase, len: 288 aa; almost identical to RFBA_NEIME P55255 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) (288 aa), fasta scores; E(): 0, 99.3% identity in 288 aa overlap, and similar to many e.g. RFBA_NEIGO P37762 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) (288 aa), fasta scores; E(): 0, 88.5% identity in 288 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. Identical to rfbA, NMA0205; glucose-1-phosphate thymidylyltransferase complement(171678..172544) Neisseria meningitidis Z2491 906203 YP_002341735.1 CDS NMA0189 NC_003116.1 172650 173675 R NMA0189, rfbB2, dTDP-glucose 4,6-dehydratase, len: 341 aa; identical to TR:AAD23919 (EMBL:AF083467) N. meningitidis MA-1 dTDP-D-glucose 4,6-dehydratase (341 aa), and similar to e.g. RFBB_NEIGO P37761 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) (346 aa), fasta scores; E(): 0, 92.4% identity in 340 aa overlap. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family. Identical to rfbB, NMA0204; dTDP-glucose 4,6-dehydratase complement(172650..173675) Neisseria meningitidis Z2491 906204 YP_002341736.1 CDS NMA0190 NC_003116.1 173791 174408 R NMA0190, galE2', truncated UDP-glucose 4-epimerase,len: 205 aa; almost identical to TR:Q51291 (EMBL:L20496) N. meningitidis MC58 truncated UDP-glucose 4-epimerase (galE2) (205 aa), fasta scores; E(): 0, 97.1% identity in 205 aa overlap, and similar to the N-terminus of many e.g. GALE_NEIGO Q05026 UDP-glucose 4-epimerase (EC 5.1.3.2) (338 aa), fasta scores; E(): 0, 87.9% identity in 206 aa overlap. Contains Pfam match to entry PF01370 Epimerase,NAD dependent epimerase/dehydratase family. Almost identical to the C-terminus of galE, NMA0203 (95.6% identity in 206 aa overlap); truncated UDP-glucose 4-epimerase complement(173791..174408) Neisseria meningitidis Z2491 906205 YP_002341737.1 CDS NMA0194 NC_003116.1 175860 178133 R NMA0194, transcriptional accessory protein, len: 757 aa; similar to hypothetical proteins e.g. YHGF_ECOLI P46837 hypothetical 85.1 kd protein in greB-feoA intergenic region (773 aa), fasta scores; E(): 0, 61.7% identity in 772 aa overlap, and to TEX_BORPE Q45388 transcriptional accessory protein TEX (791 aa), fasta scores; E(): 0, 60.4% identity in 770 aa overlap. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain; transcriptional accessory protein complement(175860..178133) Neisseria meningitidis Z2491 906208 YP_002341738.1 CDS NMA0195 NC_003116.1 178197 178847 R NMA0195, ctrD, probable capsule polysaccharide export ATP-binding protein, len: 216 aa; almost identical to CTRD_NEIME P32016 capsule polysaccharide export ATP-binding protein (216 aa), fasta scores; E(): 0, 93.5% identity in 216 aa overlap, and similar to e.g. KST5_ECOLI P24586 polysialic acid transport ATP-binding protein KPST (224 aa), fasta scores; E(): 0, 42.3% identity in 215 aa overlap. Contains Pfam match to entry PF00005 ABC_tran,ABC transporter, PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature; capsule polysaccharide export ATP-binding protein complement(178197..178847) Neisseria meningitidis Z2491 906209 YP_002341739.1 CDS NMA0196 NC_003116.1 178844 179641 R NMA0196, ctrC, capsule polysaccharide export inner-membrane protein, len: 265 aa; highly similar to CTRC_NEIME P32015 capsule polysaccharide export inner-membrane protein CTRC (265 aa), fasta scores; E(): 0, 79.2% identity in 265 aa overlap, and similar to e.g. BEX2_HAEIN P19391 capsule polysaccharide export inner-membrane protein CTRC (265 aa), fasta scores; E(): 0, 67.2% identity in 265 aa overlap. Contains Pfam match to entry PF01061 ABC2_membrane, ABC-2 type transporter, and PS00890 ABC-2 type transport system integral membrane proteins signature; capsule polysaccharide export inner-membrane protein complement(178844..179641) Neisseria meningitidis Z2491 906210 YP_002341740.1 CDS NMA0197 NC_003116.1 179641 180804 R NMA0197, ctrB, capsule polysaccharide export inner-membrane protein, len: 387 aa; highly similar to CTRB_NEIME P32014 capsule polysaccharide export inner-membrane protein CTRB (387 aa), fasta scores; E(): 0, 84.0% identity in 387 aa overlap, and similar to e.g. BEXC_HAEIN P22930 capsule polysaccharide export inner-membrane protein BEXC (377 aa), fasta scores; E(): 0, 58.6% identity in 379 aa overlap; capsule polysaccharide export inner-membrane protein complement(179641..180804) Neisseria meningitidis Z2491 906211 YP_002341741.1 CDS NMA0198 NC_003116.1 180819 181982 R NMA0198, ctrA, capsule polysaccharide export outer membrane protein, len: 387 aa; almost identical to CTR2_NEIME P32758 capsule polysaccharide export outer membrane protein CTRA precursor (387 aa), fasta scores; E(): 0, 99.7% identity in 387 aa overlap, and similar to e.g. BEXD_HAEIN P22236 capsule polysaccharide export protein BEXD (394 aa), fasta scores; E(): 0, 53.8% identity in 385 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; capsule polysaccharide export outer membrane protein complement(180819..181982) Neisseria meningitidis Z2491 906212 YP_002341742.1 CDS NMA0199 NC_003116.1 182201 183319 D NMA0199, sacA, UDP-N-acetyl-D-glucosamine 2-epimerase, len: 372 aa; almost identical to TR:O68214 (EMBL:AF019760) N. meningitidis F8229 UDP-N-acetyl-D-glucosamine 2-epimerase (372 aa), fasta scores; E(): 0, 99.7% identity in 372 aa overlap, and similar to e.g. WECB_ECOLI P27828 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) (376 aa), fasta scores; E(): 0,58.2% identity in 373 aa overlap; UDP-N-acetyl-D-glucosamine 2-epimerase 182201..183319 Neisseria meningitidis Z2491 906213 YP_002341743.1 CDS NMA0200 NC_003116.1 183321 184958 D NMA0200, sacB, capsule biosynthesis protein, len: 545 aa; almost identical to TR:O68215 (EMBL:AF019760) N. meningitidis F8229 SACB (545 aa), fasta scores; E(): 0, 99.4% identity in 545 aa overlap, and similar to hypothetical proteins e.g. TR:O06628 (EMBL:Z95618) hypothetical 60.3 kd protein Rv0806c (532 aa), fasta scores; E(): 0, 35.0% identity in 380 aa overlap; capsule biosynthesis protein 183321..184958 Neisseria meningitidis Z2491 906214 YP_002341744.1 CDS NMA0201 NC_003116.1 185031 185774 D NMA0201, sacC, capsule biosynthesis protein, len: 247 aa; identical to TR:O68216 (EMBL:AF019760) N. meningitidis F8229 SACC, (247 aa); capsule biosynthesis protein 185031..185774 Neisseria meningitidis Z2491 906215 YP_002341745.1 CDS NMA0202 NC_003116.1 185776 186639 D NMA0202, sacD, capsule biosynthesis protein, len: 287 aa; identical to TR:O68217 (EMBL:AF019760) N. meningitidis F8229 SACD (287 aa); capsule biosynthesis protein 185776..186639 Neisseria meningitidis Z2491 906216 YP_002341746.1 CDS NMA0203 NC_003116.1 186684 187703 D NMA0203, galE, UDP-glucose 4-epimerase, len: 339 aa; almost identical to GALE_NEIME Q59624 UDP-glucose 4-epimerase (EC 5.1.3.2) (339 aa), fasta scores; E(): 0,97.6% identity in 339 aa overlap, and similar toi many e.g. GALE_ECOLI P09147 UDP-glucose 4-epimerase (EC 5.1.3.2) (338 aa), fasta scores; E(): 0, 56.3% identity in 336 aa overlap. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family. Also similar in C-terminus to galE2' NMA0190 (95.6% identity in 206 aa overlap); UDP-glucose 4-epimerase 186684..187703 Neisseria meningitidis Z2491 906217 YP_002341747.1 CDS NMA0204 NC_003116.1 187819 188844 D NMA0204, rfbB, dTDP-glucose 4,6-dehydratase, len: 341 aa; identical to TR:AAD23919 (EMBL:AF083467) N. meningitidis MA-1 dTDP-D-glucose 4,6-dehydratase (341 aa), and similar to e.g. RFBB_NEIGO P37761 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) (346 aa), fasta scores; E(): 0, 92.4% identity in 340 aa overlap. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family. Identical to rfbB2, NMA0189; dTDP-glucose 4,6-dehydratase 187819..188844 Neisseria meningitidis Z2491 906218 YP_002341748.1 CDS NMA0205 NC_003116.1 188950 189816 D NMA0205, rfbA, glucose-1-phosphate thymidylyltransferase, len: 288 aa; almost identical to RFBA_NEIME P55255 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) (288 aa), fasta scores; E(): 0, 99.3% identity in 288 aa overlap, and similar to many e.g. RFBA_NEIGO P37762 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) (288 aa), fasta scores; E(): 0, 88.5% identity in 288 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. Identical to rfbA2, NMA0188; glucose-1-phosphate thymidylyltransferase 188950..189816 Neisseria meningitidis Z2491 906219 YP_002341749.1 CDS NMA0206 NC_003116.1 189855 190427 D NMA0206, rfbC, dTDP-4-dehydrorhamnose 3,5-epimerase, len: 184 aa; almost identical to TR:Q51155 (EMBL:L09189) N. meningitidis B1940 rfbC (333 aa), fasta scores; E(): 0, 93.1% identity in 189 aa overlap, and similar to many e.g. RFBC_NEIGO P37763 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (328 aa), fasta scores; E(): 0, 84.2% identity in 184 aa overlap. Contains Pfam match to entry PF00908 dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase; dTDP-4-dehydrorhamnose 3,5-epimerase 189855..190427 Neisseria meningitidis Z2491 906220 YP_002341750.1 CDS NMA0207 NC_003116.1 190470 192488 R NMA0207, probable integral membrane protein, len: 672 aa; similar to several hypothetical integral membrane proteins e.g. Y561_HAEIN P44016 hypothetical protein HI0561/560 (633 aa), fasta scores; E(): 0, 65.0% identity in 640 aa overlap; integral membrane protein complement(190470..192488) Neisseria meningitidis Z2491 906221 YP_002341751.1 CDS NMA0209 NC_003116.1 192683 193804 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ complement(192683..193804) Neisseria meningitidis Z2491 906222 YP_002341752.1 CDS NMA0210 NC_003116.1 193851 194012 D NMA0210, unknown, len: 53 aa; hypothetical protein 193851..194012 Neisseria meningitidis Z2491 906223 YP_002341753.1 CDS NMA0211 NC_003116.1 194074 194538 R NMA0211, DNA transport competence protein,len: 154 aa; region of similarity to SW:P39694 (CME1_BACSU) ComE a late competence operon protein from Bacillus subtilis (205 aa) fasta scores; E(): 6.2e-07,47.6% identity in 63 aa overlap. Almost identical to TR:CAB44958 (EMBL:AJ242837) ComEA protein (fragment) from Neisseria meningitidis serogroup A strain Z2491 (170 aa) fasta scores; E(): 0, 98.7% identity in 154 aa overlap. Contains Pfam match to entry PF00633 HHH,Helix-hairpin-helix motif and membrane-spanning hydrophobic region. Identical to NMA0423, and almost identical to NMA1915 (98.7% identity in 154 aa overlap), and NMA2187 (98.7% identity in 154 aa overlap); DNA transport competence protein complement(194074..194538) Neisseria meningitidis Z2491 906224 YP_002341754.1 CDS NMA0213 NC_003116.1 200338 200754 R NMA0213, dksA, DnaK suppressor protein,len: 138 aa; similar to e.g. DKSA_ECOLI P18274 DNAK suppressor protein (151 aa), fasta scores; opt: 376 z-score: 466.7 E(): 1.2e-18, 44.4% identity in 124 aa overlap. Contains Pfam match to entry PF01258 zf_dskA_traR, Prokaryotic dksA/traR C4-type zinc finger; DnaK suppressor protein complement(200338..200754) Neisseria meningitidis Z2491 906226 YP_002341755.1 CDS NMA0215 NC_003116.1 200901 201692 R NMA0215, proC, probable pyrroline-5-carboxylate reductase, len: 263 aa; similar to many e.g. PROC_HAEIN P00373 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (271 aa), fasta scores; E(): 4.8e-32, 39.3% identity in 267 aa overlap. Contains Pfam match to entry PF01089 P5CR, Delta 1-pyrroline-5-carboxylate reductase; pyrroline-5-carboxylate reductase complement(200901..201692) Neisseria meningitidis Z2491 906227 YP_002341756.1 CDS NMA0216 NC_003116.1 201741 202148 R NMA0216, probable lipoprotein, len: 135 aa. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein complement(201741..202148) Neisseria meningitidis Z2491 906228 YP_002341757.1 CDS NMA0217 NC_003116.1 202148 202834 R NMA0217, unknown, len: 228 aa; similar to hypothetical proteins e.g. YPT5_PSEAE P24562 (230 aa),fasta scores; E(): 0, 51.5% identity in 227 aa overlap. Pfam match to entry PF01168 UPF0001, Uncharacterized protein family UPF0001; hypothetical protein complement(202148..202834) Neisseria meningitidis Z2491 906229 YP_002341758.1 CDS NMA0218 NC_003116.1 202954 203997 D NMA0218, pilT, pilus retraction protein,len: 347 aa; almost identical to TR:O85741 (EMBL:AF074716) Neisseria meningitidis PILT (347 aa), fasta scores; E(): 0, 99.4% identity in 347 aa overlap, and similar to e.g. PILT_PSEAE P24559 twitching mobility protein (344 aa),fasta scores; E(): 0, 66.6% identity in 344 aa overlap. Contains Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein, PS00017 ATP/GTP-binding site motif A (P-loop), and PS00662 Bacterial type II secretion system protein E signature. Also similar to pilT2 NMA0979 (40.6% identity in 335 aa overlap), and pilU NMA0219 (33.7% identity in 335 aa overlap); pilus retraction protein 202954..203997 Neisseria meningitidis Z2491 906230 YP_002341759.1 CDS NMA0219 NC_003116.1 204160 205386 D NMA0219, pilU, pilT-like protein, len: 408 aa; almost identical to TR:Q06582 (EMBL:L11719) Neisseria gonorrhoeae twitching motility protein homolog (180 aa),fasta scores; E(): 0, 97.8% identity in 180 aa overlap, and similar to TR:Q51532 (EMBL:L27667) Pseudomonas aeruginosa PILU (382 aa), fasta scores; E(): 0, 44.3% identity in 368 aa overlap. Contains 2x Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein, and PS00017 ATP/GTP-binding site motif A (P-loop). Also similar to pilT2 NMA0979 (44.8% identity in 348 aa overlap) and pilT NMA0218 (33.7% identity in 335 aa overlap); twitching motility protein PilT 204160..205386 Neisseria meningitidis Z2491 906231 YP_002341760.1 CDS NMA0220 NC_003116.1 205672 207822 D NMA0220, probable integral membrane protein, len: 716 aa; simlar to several hypothetical proteins e.g. YCCS_HAEIN P44289 HI1680 (718 aa), fasta scores; E(): 0,48.2% identity in 709 aa overlap, and YCCS_ECOLI P75870 (720 aa), fasta scores; E(): 0, 36.2% identity in 704 aa overlap. Highly similar in part to YOR2_NEIGO O33369 (417 aa), fasta scores; E(): 0, 81.1% identity in 355 aa overlap. Contains two sets of six transmembrane domains between aa 1-150 and aa 370-500; integral membrane protein 205672..207822 Neisseria meningitidis Z2491 906232 YP_002341761.1 CDS NMA0221 NC_003116.1 209578 210585 R NMA0221, probable transposase for IS1106, len: 335 aa; almost identical to many e.g. TR:CAB44967 (EMBL:AJ242841) N. meningitidis transposase for IS1106A3 (335 aa), fasta scores; E(): 0, 97.0% identity in 335 aa overlap; transposase for IS1106 complement(209578..210585) Neisseria meningitidis Z2491 906233 YP_002341762.1 CDS NMA0222 NC_003116.1 211062 212519 D NMA0222, probable peptide transporter, len: 485 aa; simlar to hypothetical proteins e.g. YCLF_BACSU P94408 (492 aa), fasta scores; E(): 0, 38.6% identity in 484 aa overlap, and to DTPT_LACLA P36574 di-/tripeptide transporter (463 aa), fasta scores; E(): 0, 36.7% identity in 463 aa overlap. Contains Pfam match to entry PF00854 PTR2, Peptide transporter family, and PS01023 PTR2 family proton/oligopeptide symporters signature 2; peptide transporter 211062..212519 Neisseria meningitidis Z2491 906234 YP_002341763.1 CDS prfB NC_003116.1 213431 214534 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(213431..214534) Neisseria meningitidis Z2491 906236 YP_002341764.1 CDS NMA0225 NC_003116.1 214637 215539 R NMA0225, lipoprotein, len: 300 aa; similar to hypothetical proteins e.g. YCHK_ECOLI (314 aa), fasta scores; E(): 1.2e-17, 36.6% identity in 194 aa overlap. Contains Pfam match to entry PF01173 UPF0028,Uncharacterized protein family UPF0028, N-terminal signal sequence, and PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein complement(214637..215539) Neisseria meningitidis Z2491 906237 YP_002341765.1 CDS NMA0226 NC_003116.1 215872 216321 D NMA0226, probable integral membrane protein, len: 149 aa; similar to YG02_HAEIN P44270 HI1602 (151 aa),fasta scores; E(): 1.5e-32, 58.8% identity in 136 aa overlap. Also similar to NMA2196 (34.1% identity in 129 aa overlap); integral membrane protein 215872..216321 Neisseria meningitidis Z2491 906238 YP_002341766.1 CDS NMA0227 NC_003116.1 216395 216703 D NMA0227, probable periplasmic protein, len: 102 aa; similar to YG01_HAEIN P44269 HI1601 precursor (95 aa),fasta scores; E(): 3.9e-09, 48.0% identity in 100 aa overlap. Contains N-terminal signal sequence; hypothetical protein 216395..216703 Neisseria meningitidis Z2491 906239 YP_002341767.1 CDS NMA0228 NC_003116.1 216819 217661 D NMA0228, unknown, len: 280 aa; similar to YG00_HAEIN P44268 HI1600 (317 aa), fasta scores; E(): 0,66.0% identity in 294 aa overlap; hypothetical protein 216819..217661 Neisseria meningitidis Z2491 906240 YP_002341768.1 CDS NMA0229 NC_003116.1 217651 218397 D NMA0229, unknown, len: 248 aa; similar to YF99_HAEIN P44267 HI1599 (238 aa), fasta scores; E(): 1.3e-24, 36.1% identity in 227 aa overlap; hypothetical protein 217651..218397 Neisseria meningitidis Z2491 906241 YP_002341769.1 CDS NMA0230 NC_003116.1 218419 219006 D Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 218419..219006 Neisseria meningitidis Z2491 906242 YP_002341770.1 CDS NMA0233 NC_003116.1 219450 219872 D NMA0233, probable lipoprotein, len: 140 aa. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 219450..219872 Neisseria meningitidis Z2491 906243 YP_002341771.1 CDS NMA0237 NC_003116.1 222047 222649 R NMA0237, unknown, len: 200 aa; similar to hypothetical proteins e.g. YRDC_ECOLI P45748 (190 aa),fasta scores; E(): 4.4e-20, 41.7% identity in 168 aa overlap. Contains Pfam match to entry PF01300 Sua5_yciO_yrdC, SUA5/yciO/yrdC family, PS01147 SUA5/yciO/yrdC family signature, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; hypothetical protein complement(222047..222649) Neisseria meningitidis Z2491 906246 YP_002341772.1 CDS purD NC_003116.1 222683 223954 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(222683..223954) Neisseria meningitidis Z2491 906247 YP_002341773.1 CDS NMA0239 NC_003116.1 224111 224428 D NMA0239, unknowwn, len: 105 aa; hypothetical protein 224111..224428 Neisseria meningitidis Z2491 906248 YP_002341774.1 CDS NMA0240 NC_003116.1 224480 225091 R NMA0240, unknown, len: 203 aa; similar to hypothetical proteins e.g. YIGZ_ECOLI P27862 (205 aa),fasta scores; E(): 6.5e-16, 36.3% identity in 160 aa overlap. Contains Pfam match to entry PF01205 UPF0029,Uncharacterized protein family UPF0029, and PS00910 Uncharacterized protein family UPF0029 signature; hypothetical protein complement(224480..225091) Neisseria meningitidis Z2491 906249 YP_002341775.1 CDS NMA0241 NC_003116.1 225154 226089 R NMA0241, etfA, electron transfer flavoprotein alpha-subunit, len: 311 aa; highly similar to many e.g. ETFA_BRAJA P53573 electron transfer flavoprotein alpha-subunit (314 aa), fasta scores; E(): 0, 59.4% identity in 310 aa overlap, and ETFA_HUMAN P13804 electron transfer flavoprotein alpha-subunit (333 aa), fasta scores; E(): 0, 55.1% identity in 312 aa overlap. Contains Pfam match to entry PF00766 ETF_alpha, Electron transfer flavoprotein alpha subunit; electron transfer flavoprotein subunit alpha complement(225154..226089) Neisseria meningitidis Z2491 906250 YP_002341776.1 CDS NMA0242 NC_003116.1 226100 226849 R NMA0242, etfB, flaX, electron transfer flavoprotein beta-subunit, len: 249 aa; almost identical to TR:Q51129 (EMBL:U40862) N. meningitidis FLAX (249 aa), fasta scores; E(): 0,97.2% identity in 249 aa overlap, and highly similar to e.g. ETFB_BRAJA P53575 electron transfer flavoprotein beta-subunit (249 aa), fasta scores; E(): 0,62.7% identity in 249 aa overlap, and ETFB_HUMAN P38117 electron transfer flavoprotein beta-subunit (255 aa),fasta scores; E(): 0, 55.6% identity in 252 aa overlap. Contains Pfam match to entry PF01012 ETF_beta, Electron transfer flavoprotein beta subunit; electron transfer flavoprotein subunit beta complement(226100..226849) Neisseria meningitidis Z2491 906251 YP_002341777.1 CDS NMA0243 NC_003116.1 227075 228043 R NMA0243, rfaC, lipopolysaccharide heptosyltransferase I, len: 322 aa; almost identical to TR:Q51122 (EMBL:U35454) N. meningitidis heptosyltransferase I (322 aa), fasta scores; E(): 0,97.8% identity in 322 aa overlap, and similar to e.g. RFAC_ECOLI P24173 lipopolysaccharide heptosyltransferase-1 (319 aa), fasta scores; E(): 0, 40.8% identity in 287 aa overlap. Contains Pfam match to entry PF01075 Heptosyltranf, Heptosyltransferase; lipopolysaccharide heptosyltransferase I complement(227075..228043) Neisseria meningitidis Z2491 906252 YP_002341778.1 CDS NMA0244 NC_003116.1 228080 228715 R NMA0244, pncA, probable nicotinamidase, len: 211 aa; similar to e.g. PNCA_ECOLI P21369 pyrazinamidase/nicotinamidase [includes: pyrazinamidase (EC 3.5.1.-) (PZASE); nicotinamidase (EC 3.5.1.19) (nicotine deamidase)] (213 aa), fasta scores; E(): 7e-09,32.5% identity in 212 aa overlap; nicotinamidase complement(228080..228715) Neisseria meningitidis Z2491 906253 YP_002341779.1 CDS NMA0245 NC_003116.1 228830 229510 D NMA0245, unknown, len: 226 aa; similar to hypothetical proteins e.g. YAEB_ECOLI P28634 (235 aa),fasta scores; opt: 578 z-score: 695.1 E(): 2.3e-31 41.8% identity in 232 aa overlap; hypothetical protein 228830..229510 Neisseria meningitidis Z2491 906254 YP_002341780.1 CDS NMA0246 NC_003116.1 229768 230772 R NMA0246, gapC, glyceraldehyde 3-phosphate dehydrogenase C, len: 334 aa; highly similar to many e.g. G3P_CLOPA Q59309 glyceraldehyde 3-phosphate dehydrogenase (EC 1.1.1.2842) (334 aa), fasta scores; E(): 0, 75.9% identity in 328 aa overlap, and G3P3_ECOLI P33898 glyceraldehyde 3-phosphate dehydrogenase C (EC 1.1.1.2842) (332 aa), fasta scores; E(): 0, 57.1% identity in 331 aa overlap. Contains Pfam match to entry PF00044 gpdh,glyceraldehyde 3-phosphate dehydrogenases, and PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. Also similar to gapA, NMA0062 (50.7% identity in 341 aa overlap); glyceraldehyde 3-phosphate dehydrogenase C complement(229768..230772) Neisseria meningitidis Z2491 906255 YP_002341781.1 CDS mutS NC_003116.1 231216 233810 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 231216..233810 Neisseria meningitidis Z2491 906256 YP_002341782.1 CDS NMA0248 NC_003116.1 233934 234425 R NMA0248, acetyltransferase, len: 163 aa; contains weak similarity to predicted acetyltransferases e.g. TR:Q50708 (EMBL:Z77165) M. tuberculosis ribosomal-protein-alanine acetyltransferase (158 aa),fasta scores; E(): 0.00045, 30.5% identity in 154 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; acetyltransferase complement(233934..234425) Neisseria meningitidis Z2491 906257 YP_002341783.1 CDS NMA0249 NC_003116.1 234429 234770 R NMA0249, probable periplasmic protein, len: 113 aa; contains probable N-terminal signal sequence and coiled-coil domain around aa 50; hypothetical protein complement(234429..234770) Neisseria meningitidis Z2491 906258 YP_002341784.1 CDS gltX NC_003116.1 234845 236239 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(234845..236239) Neisseria meningitidis Z2491 906259 YP_002341785.1 CDS NMA0251 NC_003116.1 236355 237011 R NMA0251, probable periplasmic protein, len: 218 aa; some similarity to e.g. TR:O07474 (EMBL:U61158) Staphylococcus gallinarum GDMH protein involved in antibiotic gallidermin secretion (330 aa), fasta scores; E(): 1.5e-06, 29.5% identity in 129 aa overlap, and SANA_ECOLI P33017 SANA protein involved in the barrier function of the cell envelope (239 aa), fasta scores; E(): 0.00013, 23.6% identity in 212 aa overlap. Contains N-terminal signal sequence; hypothetical protein complement(236355..237011) Neisseria meningitidis Z2491 906260 YP_002341786.1 CDS NMA0252 NC_003116.1 237008 237361 R NMA0252, probable oxidoreductase, len: 117 aa; similar to YFGD_ECOLI P76569 hypothetical protein (119 aa), fasta scores; E(): 1.2e-23, 53.9% identity in 115 aa overlap, and to e.g. ARC2_ECOLI P52147 arsenate reductase (141 aa), fasta scores; E(): 8.3e-12, 35.9% identity in 117 aa overlap; oxidoreductase complement(237008..237361) Neisseria meningitidis Z2491 906261 YP_002341787.1 CDS NMA0253 NC_003116.1 237485 237967 D NMA0253, probable periplasmic thiredoxin, len: 160 aa; similar to e.g. TLPA_BRAJA P43221 thiol:disulfide interchange protein TLPA (221 aa), fasta scores; E(): 7.4e-08, 30.7% identity in 153 aa overlap; periplasmic thiredoxin 237485..237967 Neisseria meningitidis Z2491 906262 YP_002341788.1 CDS NMA0254 NC_003116.1 238162 238812 D NMA0254, ftsE, probable ABC transporter ATP-binding protein, len: 305 aa; similar to e.g. FTSE_ECOLI P10115 cell division ATP-binding protein FTSE (222 aa), fasta scores; E(): 0, 50.2% identity in 215 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter; ABC transporter ATP-binding protein 238162..238812 Neisseria meningitidis Z2491 906263 YP_002341789.1 CDS NMA0255 NC_003116.1 238809 239726 D NMA0255, ftsX, probable ABC transporter integral membrane protein, len: 305 aa; similar to e.g. FTSX_ECOLI P10122 cell division protein FTSX (352 aa), fasta scores; E(): 2.6e-20, 29.5% identity in 288 aa overlap; ABC transporter 238809..239726 Neisseria meningitidis Z2491 906264 YP_002341790.1 CDS NMA0256 NC_003116.1 239818 240066 D NMA0256, unknown, len: 82 aa; similar to hypothetical proteins e.g. YV22_SYNY3 P73055 SSR3122 (85 aa), fasta scores; E(): 1.5e-06, 35.7% identity in 84 aa overlap, and YRBA_ECOLI P43781 (84 aa), fasta scores; E(): 6e-06, 31.5% identity in 73 aa overlap; hypothetical protein 239818..240066 Neisseria meningitidis Z2491 906265 YP_002341791.1 CDS pgk NC_003116.1 240133 241311 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(240133..241311) Neisseria meningitidis Z2491 906266 YP_002341792.1 CDS murA NC_003116.1 241392 242645 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(241392..242645) Neisseria meningitidis Z2491 906267 YP_002341793.1 CDS NMA0259 NC_003116.1 243161 244135 R NMA0259, probable transmembrane transport protein,len: 324 aa; similar to hypothetical membrane proteins e.g. YGJT_ECOLI P42601 (321 aa), fasta scores; E(): 0,55.5% identity in 301 aa overlap, and to TERC_ALCSP P18780 tellurium resistance protein TERC (346 aa), fasta scores; E(): 1.4e-11, 34.8% identity in 345 aa overlap; transmembrane transport protein complement(243161..244135) Neisseria meningitidis Z2491 906268 YP_002341794.1 CDS NMA0260 NC_003116.1 244168 244617 R NMA0260, probable integral membrane protein, len: 149 aa; similar to TR:O26032 (EMBL:AE000648) Helicabacter pylori HP1502 (145 aa), fasta scores; E(): 2.3e-09, 29.5% identity in 149 aa overlap; integral membrane protein complement(244168..244617) Neisseria meningitidis Z2491 906269 YP_002341795.1 CDS kdtA NC_003116.1 244658 245929 R catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase complement(244658..245929) Neisseria meningitidis Z2491 906270 YP_002341796.1 CDS gnd NC_003116.1 245992 247440 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(245992..247440) Neisseria meningitidis Z2491 906271 YP_002341797.1 CDS lpxC NC_003116.1 248626 249549 R zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase complement(248626..249549) Neisseria meningitidis Z2491 906272 YP_002341798.1 CDS NMA0264 NC_003116.1 250476 250988 R NMA0264, pilE, fimbrial protein precursor (pilin),len: 170 aa; highly similar to e.g. FMM1_NEIME P05431 fimbrial protein precursor (pilin) (167 aa), fasta scores; E(): 0, 85.2% identity in 169 aa overlap. Contains Pfam match to entry PF00114 pilin, and PS00409 Prokaryotic N-terminal methylation site; fimbrial protein (pilin) complement(250476..250988) Neisseria meningitidis Z2491 906273 YP_002341799.1 CDS NMA0272 NC_003116.1 256488 256850 R NMA0272, pilS8, pilin, partial CDS, len: 113 aa; highly similar to e.g. FMD3_NEIGO Q00046 fimbrial protein MS11-D3A precursor (L-pilin) (180 aa), fasta scores; E(): 1.3e-16, 63.0% identity in 81 aa overlap; truncated pilin complement(256488..256850) Neisseria meningitidis Z2491 906281 YP_002341800.1 CDS NMA0273 NC_003116.1 256879 257208 R NMA0273, fbp, peptidyl-prolyl cis-trans isomerase,len: 109aa; almost identical to FKBP_NEIME P25138 FK506-binding protein (peptidyl-prolyl cis-trans isomerase) (PPIASE) (EC 5.2.1.8) (109 aa), fasta scores; E(): 0, 97.2% identity in 109 aa overlap. Contains Pfam match to entry PF00254 FKBP, FKBP-type peptidyl-prolyl cis-trans isomerases, PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1, and PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. Also similar to NMA1756 (45.9% identity in 98 aa overlap); peptidyl-prolyl cis-trans isomerase complement(256879..257208) Neisseria meningitidis Z2491 906282 YP_002341801.1 CDS NMA0274 NC_003116.1 257779 258732 D NMA0274, glycerate dehydrogenase, len: 322 aa; similar to DHGY_METEX Q59516 glycerate dehydrogenase (EC 1.1.1.29) (313 aa), fasta scores; E(): 0, 47.8% identity in 316 aa overlap, and to e.g. SERA_RAT O08651 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) (533 aa),fasta scores; E(): 2.4e-26, 31.4% identity in 322 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH,D-isomer specific 2-hydroxyacid dehydrogenases, PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2, and PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3; glycerate dehydrogenase 257779..258732 Neisseria meningitidis Z2491 906283 YP_002341802.1 CDS metG NC_003116.1 258807 260864 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(258807..260864) Neisseria meningitidis Z2491 906284 YP_002341803.1 CDS glmS NC_003116.1 260980 262818 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(260980..262818) Neisseria meningitidis Z2491 906285 YP_002341804.1 CDS NMA0277 NC_003116.1 263100 263618 D NMA0277, probable lipoprotein, len: 172 aa. Contains N-terminal signal sequence, and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 263100..263618 Neisseria meningitidis Z2491 906286 YP_002341805.1 CDS NMA0279 NC_003116.1 264036 265361 R NMA0279, probable membrane-bound lytic murein transglycosylase, len: 441 aa; similar to MLTA_ECOLI P46885 membrane-bound lytic murein transglycosylase A precursor (EC 3.2.1.-) (365 aa), fasta scores; E(): 1.4e-16, 27.7% identity in 441 aa overlap. Contains N-terminal signal sequence, and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; membrane-bound lytic murein transglycosylase complement(264036..265361) Neisseria meningitidis Z2491 906287 YP_002341806.1 CDS NMA0280 NC_003116.1 265572 266411 D NMA0280, probable integral membrane protein, len: 279 aa; similar to hypothetical membrane proteins e.g. YCDN_ECOLI P75901 (276 aa), fasta scores; E(): 0, 51.5% identity in 274 aa overlap; integral membrane protein 265572..266411 Neisseria meningitidis Z2491 906288 YP_002341807.1 CDS NMA0281 NC_003116.1 266408 267574 D NMA0281, probable lipoprotein, len: 388 aa; similar to hypothetical proteins e.g. YCDO_ECOLI P75902 (375 aa),fasta scores; E(): 0, 62.8% identity in 360 aa overlap. Contains N-terminal signals sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; hypothetical protein 266408..267574 Neisseria meningitidis Z2491 906289 YP_002341808.1 CDS NMA0282 NC_003116.1 267838 269103 D NMA0282, periplasmic protein, len: 421 aa; similar to e.g. YCDB_ECOLI P31545 hypothetical lipoprotein (423 aa), fasta scores; E(): 0, 49.5% identity in 424 aa overlap. Contains N-terminal signal sequence; hypothetical protein 267838..269103 Neisseria meningitidis Z2491 906290 YP_002341809.1 CDS NMA0283 NC_003116.1 269175 269504 R NMA0283, phnA, PhnA protein NMB_orthologue, len: 109 aa; similar to many e.g. PHNA_ECOLI P16680 PHNA protein (111 aa), fasta scores; E(): 4.7e-25, 68.2% identity in 110 aa overlap; PhnA protein NMB_orthologue complement(269175..269504) Neisseria meningitidis Z2491 906291 YP_002341810.1 CDS NMA0284 NC_003116.1 269581 270951 R NMA0284, glmU, UDP-N-acetylglucosamine pyrophosphorylase, len: 456 aa; similar to amny e.g. GLMU_NEIGO Q50986 UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (456 aa), fasta scores; E(): 0, 91.7% identity in 456 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase, and 2x Pfam match to entry PF00132 hexapep,Bacterial transferase hexapeptide (four repeats); UDP-N-acetylglucosamine pyrophosphorylase complement(269581..270951) Neisseria meningitidis Z2491 906292 YP_002341811.1 CDS NMA0287 NC_003116.1 272044 273045 D NMA0287, tbpA, probable thiamin-binding periplasmic protein, len: 333 aa; similar to e.g. TBPA_ECOLI P31550 thiamin-binding periplasmic protein precursor (327 aa),fasta scores; E(): 3.3e-21, 30.9% identity in 333 aa overlap. Contains N-terminal signal sequence; thiamin-binding periplasmic protein 272044..273045 Neisseria meningitidis Z2491 906295 YP_002341812.1 CDS NMA0288 NC_003116.1 273139 273987 D NMA0288, probable integral membrane protein, len: 282 aa; similar to hypothetical integral membrane proteins e.g. YGGB_ECOLI P11666 (286 aa), fasta scores; E(): 7.2e-31, 34.3% identity in 268 aa overlap. Contains Pfam match to entry PF00924 UPF0003, Uncharacterized protein family UPF0003; integral membrane protein 273139..273987 Neisseria meningitidis Z2491 906296 YP_002341813.1 CDS NMA0289 NC_003116.1 274013 274498 D NMA0289, unknown, len: 161 aa; similar to hypothetical proteins e.g. YGAD_ENTAG P51967 (164 aa),fasta scores; E(): 3.4e-26, 55.9% identity in 152 aa overlap, and to the C-terminus of CINA_STRPN P54184 competence-damage protein (418 aa), fasta scores; E(): 7e-11, 37.1% identity in 151 aa overlap; hypothetical protein 274013..274498 Neisseria meningitidis Z2491 906297 YP_002341814.1 CDS NMA0290 NC_003116.1 274600 276168 R NMA0290, pilB, probable peptide methionine sulfoxide reductase, len: 522 aa; almost identical to PMSR_NEIGO P14930 peptide methionine sulfoxide reductase (521 aa), fasta scores; E(): 0, 88.0% identity in 527 aa overlap, and similar in C-terminus to e.g. PMSR_STRPN P35593 peptide methionine sulfoxide reductase (312 aa),fasta scores; E(): 4.9e-31, 51.7% identity in 317 aa overlap, and in N-terminus to e.g. THIO_STRCO P52230 thioredoxin (110 aa), blastp scores; Expect = 0.0028, 30% identity in 107 aa overlap; trifunctional thioredoxin/methionine sulfoxide reductase A/B protein complement(274600..276168) Neisseria meningitidis Z2491 906298 YP_002341815.1 CDS NMA0291 NC_003116.1 276314 277579 D NMA0291, pilA, ftsY, probable signal recognition particle protein, len: 421 aa; almost identical to PILA_NEIME O30391 probable signal recognition particle protein (421 aa), fasta scores; E(): 0, 97.9% identity in 421 aa overlap, and highly similar to e.g. FTSY_ECOLI P10121 cell division protein FTSY (497 aa), fasta scores; E(): 0, 47.6% identity in 412 aa overlap. Contains Pfam match to entry PF00448 SRP54, SRP54-type protein, PS00017 ATP/GTP-binding site motif A (P-loop), and PS00300 SRP54-type proteins GTP-binding domain signature; signal recognition particle protein 276314..277579 Neisseria meningitidis Z2491 906299 YP_002341816.1 CDS NMA0292 NC_003116.1 278168 278452 D NMA0292, unknown, len: aa; almost identical to TR:O33368 (EMBL:AJ002423) N. gonorrhoeae hypothetical 11.4 kd protein (94 aa), fasta scores; E(): 0, 96.8% identity in 94 aa overlap. Also similar to NMA0011, fasta scores; E(): 5.4e-19; 54.2% identity in 83 aa overlap; hypothetical protein 278168..278452 Neisseria meningitidis Z2491 906300 YP_002341817.1 CDS NMA0293 NC_003116.1 279084 282250 D NMA0293, pilC2, pilus-associated protein,pseudogene, len: 30 aa; N-terminus identical to the N-terminus of TR:O05925 (EMBL:Y13021) N. meningitidis FAM20 pilC2 (1048 aa). C-terminus highly similar to the C-terminus of TR:O05925 (EMBL:Y13021) N. meningitidis FAM20 pilC2 (6248 bp), fasta scores; E(): 0, 75.2% identity in 1036 aa overlap. Contains a (g)11 tract at aa 27 that, if variable, would allow translation as an intact CDS. Also similar to NMA0609, pilC1 (intact) (90% identity in 30 aa overlap and 82.8% identity in 1050 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Coding sequence has been spliced to give intact translation; hypothetical protein join(279084..279167,279167..282250) Neisseria meningitidis Z2491 906301 YP_002341818.1 CDS NMA0295 NC_003116.1 283684 287799 R NMA0295, probable periplasmic protein, len: 1371 aa; some similarity to YTFN_ECOLI P39321 hypothetical 136.8 kd protein (1259 aa), fasta scores; E(): 2.2e-17,21.6% identity in 1403 aa overlap. Contains N-terminal signal sequence; hypothetical protein complement(283684..287799) Neisseria meningitidis Z2491 906302 YP_002341819.1 CDS NMA0296 NC_003116.1 287908 289755 R NMA0296, probable outer membrane protein, len: 615 aa; some similarity to e.g. YTFM_ECOLI P39320 hypothetical protein (577 aa), fasta scores; E(): 2.3e-20, 23.4% identity in 569 aa overlap, and to TR:P95359 (EMBL:U81959) N. gonorrhoeae outer membrane protein omp85 (792 aa),fasta scores; E(): 0.0031, 23.2% identity in 595 aa overlap; outer membrane protein complement(287908..289755) Neisseria meningitidis Z2491 906303 YP_002341820.1 CDS NMA0298 NC_003116.1 290320 291549 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 290320..291549 Neisseria meningitidis Z2491 906304 YP_002341821.1 CDS NMA0299 NC_003116.1 291661 293154 D NMA0299, probable periplasmic protein, len: 497 aa; contains N-terminal signal sequence; hypothetical protein 291661..293154 Neisseria meningitidis Z2491 906305 YP_002341822.1 CDS NMA0300 NC_003116.1 293229 293444 R NMA0300, probable integral membrane protein, len: 71 aa; integral membrane protein complement(293229..293444) Neisseria meningitidis Z2491 906306 YP_002341823.1 CDS NMA0301 NC_003116.1 293437 293652 R NMA0301, unknonwn, len: 71 aa; hypothetical protein complement(293437..293652) Neisseria meningitidis Z2491 906307 YP_002341824.1 CDS argG NC_003116.1 293859 295202 R catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase complement(293859..295202) Neisseria meningitidis Z2491 906308 YP_002341825.1 CDS NMA0304 NC_003116.1 295327 296127 D NMA0304, unknown, len: 266 aa; similar to hypothetical proteins e.g. TR:AAD42399 (EMBL:AF157493) Zymomonas mobilis hypothetical competence-damage protein ZM10ORF4 (253 aa), fasta scores; E(): 8.4e-12, 31.1% identity in 209 aa overlap, and weakly simar to the N-terminus of e.g. CINA_BACSU P46323 competence-damage protein (416 aa), fasta scores; E(): 0.00012, 25.6% identity in 254 aa overlap; hypothetical protein 295327..296127 Neisseria meningitidis Z2491 906309 YP_002341826.1 CDS NMA0305 NC_003116.1 296167 297153 D NMA0305, probable protease, len: 328 aa; similar to part of e.g. SPPA_SYNY3 P73689 protease IV homolog (610 aa), fasta scores; E(): 1.4e-14, 32.7% identity in 211 aa overlap, and SPPA_ECOLI P08395 protease IV (618 aa), fasta scores; E(): 2.5e-10, 29.2% identity in 271 aa overlap. Contains Pfam match to entry PF01343 Peptidase_U7,Peptidase family U7; protease 296167..297153 Neisseria meningitidis Z2491 906310 YP_002341827.1 CDS NMA0307 NC_003116.1 298110 298484 R NMA0307, unknown, len: 124 aa; similar to upstream gene NMA0320 (45.6% identity in 125 aa overlap); hypothetical protein complement(298110..298484) Neisseria meningitidis Z2491 906314 YP_002341828.1 CDS NMA0307A NC_003116.1 298481 298609 R hypothetical protein complement(298481..298609) Neisseria meningitidis Z2491 7163863 YP_002341829.1 CDS NMA0308 NC_003116.1 298657 299013 R NMA0308, unknown, len: 118 aa; hypothetical protein complement(298657..299013) Neisseria meningitidis Z2491 906315 YP_002341830.1 CDS NMA0310 NC_003116.1 299156 299500 R NMA0310, unknown, len: 114 aa; hypothetical protein complement(299156..299500) Neisseria meningitidis Z2491 906320 YP_002341831.1 CDS NMA0311 NC_003116.1 299659 300060 R NMA0311, unknown, len: 133 aa; similar to NMA2120 (32.8% identity in 128 aa overlap); hypothetical protein complement(299659..300060) Neisseria meningitidis Z2491 906321 YP_002341832.1 CDS NMA0314 NC_003116.1 300863 301180 R NMA0314, unknown, len: 105 aa; hypothetical protein complement(300863..301180) Neisseria meningitidis Z2491 906323 YP_002341833.1 CDS NMA0316 NC_003116.1 301872 302174 R NMA0316, unknown, len 100 aa; hypothetical protein complement(301872..302174) Neisseria meningitidis Z2491 906324 YP_002341834.1 CDS NMA0317 NC_003116.1 302197 302466 R NMA0317, unknown, len: 89 aa; hypothetical protein complement(302197..302466) Neisseria meningitidis Z2491 906325 YP_002341835.1 CDS NMA0318 NC_003116.1 302487 302693 R NMA0318, unknown, len: 68 aa; hypothetical protein complement(302487..302693) Neisseria meningitidis Z2491 906326 YP_002341836.1 CDS NMA0320 NC_003116.1 303514 303885 R NMA0320, unknown, len: 123 aa. Similar to NMA0307 (45.6% identity in 125 aa overlap); hypothetical protein complement(303514..303885) Neisseria meningitidis Z2491 906327 YP_002341837.1 CDS NMA0321 NC_003116.1 303882 304088 R NMA0321, unknown, len: 68 aa; hypothetical protein complement(303882..304088) Neisseria meningitidis Z2491 906328 YP_002341838.1 CDS NMA0322 NC_003116.1 304091 304252 R NMA0322, unknown, len: 53 aa; hypothetical protein complement(304091..304252) Neisseria meningitidis Z2491 906329 YP_002341839.1 CDS NMA0323 NC_003116.1 304265 304471 R NMA0323, unknown, len: 68 aa. Similar to NMA0024 (46.4% identity in 69 aa overlap); hypothetical protein complement(304265..304471) Neisseria meningitidis Z2491 906330 YP_002341840.1 CDS NMA0324 NC_003116.1 304481 305929 R NMA0324, mafB, adhesin, len: 492 aa; almost identical to TR:AAD31039 (EMBL:AF142582) Neisseria gonorrhoeae MS11 adhesin MAFB (509 aa), fasta scores; E(): 0, 72.6% identity in 503 aa overlap, but varying in the C-terminus. An identical sequence to the C-terminus is present in NMA0319 (mafB'). NMA0319, NMA0315, NMA0313 and NMA0309 contain perfect direct repeats from this gene, and may represent alternative C-termini. Contains N-terminal signal sequence. Also similar to NMA2113 (31.4% identity in 500 aa overlap), and NMA0853 (33.5% identity in 376 aa overlap); adhesin complement(304481..305929) Neisseria meningitidis Z2491 906331 YP_002341841.1 CDS NMA0325 NC_003116.1 305969 306931 R NMA0325, mafA, adhesin, len: 320 aa; almost identical to TR:AAD31038 (EMBL:AF142582) Neisseria gonorrhoeae MS11 adhesin MAFA (320 aa), fastaa scores; E(): 0, 98.4% identity in 320 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; adhesin complement(305969..306931) Neisseria meningitidis Z2491 906332 YP_002341842.1 CDS pyrH NC_003116.1 307114 307833 R Catalyzes the phosphorylation of UMP to UDP; uridylate kinase complement(307114..307833) Neisseria meningitidis Z2491 906333 YP_002341843.1 CDS tsf NC_003116.1 308156 309010 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(308156..309010) Neisseria meningitidis Z2491 906334 YP_002341844.1 CDS rpsB NC_003116.1 309139 309867 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(309139..309867) Neisseria meningitidis Z2491 906335 YP_002341845.1 CDS NMA0329 NC_003116.1 310068 310277 R NMA0329, integral membrane protein, len: 69 aa; integral membrane protein complement(310068..310277) Neisseria meningitidis Z2491 906336 YP_002341846.1 CDS NMA0330 NC_003116.1 310355 310936 D NMA0330, unknown, len: 193 aa; similar to hypothetical proteins e.g. YGFA_HAEIN P44905 hypothetical protein HI0858 (187 aa), fasta scores; E(): 5e-11, 27.8% identity in 194 aa overlap, and to e.g. FTHC_HUMAN P49914 5-formyltetrahydrofolate cyclo-ligase (202 aa), fasta scores; E(): 6.7e-07, 24.1% identity in 191 aa overlap; hypothetical protein 310355..310936 Neisseria meningitidis Z2491 906337 YP_002341847.1 CDS NMA0331 NC_003116.1 310997 311587 D NMA0331, unknown, len: 196 aa; similar to hypothetical proteins e.g. TR:O54394 (EMBL:U81516) hypothetical 24.4 kd protein (216 aa), fasta scores; E(): 4.2e-19, 37.2% identity in 199 aa overlap; hypothetical protein 310997..311587 Neisseria meningitidis Z2491 906338 YP_002341848.1 CDS mqo NC_003116.1 312124 313590 D malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 312124..313590 Neisseria meningitidis Z2491 906339 YP_002341849.1 CDS NMA0335 NC_003116.1 313778 314338 R NMA0335, adhesin component, len: 186 aa; similar to TR:P94741 (EMBL:D78153) Eikenella corrodens component protein of adhesin complex (226 aa), fasta scores; E(): 3.9e-08, 43.9% identity in 98 aa overlap; adhesin component complement(313778..314338) Neisseria meningitidis Z2491 906340 YP_002341850.1 CDS NMA0336 NC_003116.1 314390 314689 R NMA0336, unknown, len: 99 aa; hypothetical protein complement(314390..314689) Neisseria meningitidis Z2491 906341 YP_002341851.1 CDS NMA0337 NC_003116.1 314844 315623 R NMA0337, map, methionine aminopeptidase, len: 259 aa; similar to many e.g. AMPM_ECOLI P07906 methionine aminopeptidase (EC 3.4.11.18) (264 aa), fasta scores; E(): 0, 56.4% identity in 257 aa overlap. Contains Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24, and PS00680 Methionine aminopeptidase subfamily 1 signature; methionine aminopeptidase complement(314844..315623) Neisseria meningitidis Z2491 906342 YP_002341852.1 CDS NMA0338 NC_003116.1 315663 316256 R NMA0338, probable periplasmic protein, len: 197 aa; contains N-terminal signal sequence and P-,E-rich C-terminal region; hypothetical protein complement(315663..316256) Neisseria meningitidis Z2491 906343 YP_002341853.1 CDS NMA0339 NC_003116.1 316321 316929 R NMA0339, probable lipoprotein, len: 202 aa; similar to hypothetical proteins e.g. YRAP_ECOLI P45467 (191 aa),fasta scores; E(): 4.8e-14, 35.0% identity in 183 aa overlap, and to HLY2_ACTPL P46028 Actinobacillus pleuropneumoniae 21 KD hemolysin precursor (194 aa), fasta scores; E(): 9.2e-10, 32.3% identity in 164 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein complement(316321..316929) Neisseria meningitidis Z2491 906344 YP_002341854.1 CDS gmhA NC_003116.1 316993 317586 R catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase complement(316993..317586) Neisseria meningitidis Z2491 906345 YP_002341855.1 CDS NMA0341 NC_003116.1 317591 317938 R NMA0341, unknown, len: 115 aa; similar to hypothetical proteins e.g. YRAN_ECOLI P45465 (131 aa),fasta scores; E(): 7.4e-11, 37.7% identity in 114 aa overlap; hypothetical protein complement(317591..317938) Neisseria meningitidis Z2491 906346 YP_002341856.1 CDS NMA0342 NC_003116.1 317991 318866 D NMA0342, unknown, len: 291 aa; similar to many hypothetical proteins e.g. YRAL_ECOLI P45528 (286 aa),fasta scores; E(): 0, 44.4% identity in 284 aa overlap. Contains Pfam match to entry PF00590 TP_methylase,Tetrapyrrole (Corrin/Porphyrin) Methylases; hypothetical protein 317991..318866 Neisseria meningitidis Z2491 906347 YP_002341857.1 CDS NMA0343 NC_003116.1 318901 319305 R NMA0343, cybB, probable cytochrome B561, len: 134 aa; similar to e.g. C561_ECOLI P08732 cytochrome B561 (176 aa), fasta scores; E(): 0.00015, 30.6% identity in 134 aa overlap; cytochrome B561 complement(318901..319305) Neisseria meningitidis Z2491 906348 YP_002341858.1 CDS obgE NC_003116.1 320559 321713 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 320559..321713 Neisseria meningitidis Z2491 906351 YP_002341859.1 CDS NMA0346 NC_003116.1 321796 322845 D NMA0346, probable ATP-binding protein, len: 349 aa; Also similar to NMA0935 (28.7% identity in 338 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); ATP-binding protein 321796..322845 Neisseria meningitidis Z2491 906352 YP_002341860.1 CDS cysS NC_003116.1 322855 324954 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 322855..324954 Neisseria meningitidis Z2491 906353 YP_002341861.1 CDS NMA0348 NC_003116.1 325037 325816 D NMA0348, nuclease, len: 259 aa; similar to EXOA_BACSU P37454 exodeoxyribonuclease (252 aa), fasta scores; E(): 0, 39.0% identity in 251 aa overlap, and TR:Q51380 (EMBL:U38241) Pseudomonas aeruginosa catabolite repression control protein (259 aa), fasta scores; E(): 0,37.3% identity in 255 aa overlap, and APE1_HUMAN P27695 DNA-(apurinic or apyrimidinic site) lyase (317 aa), fasta scores; E(): 0, 35.8% identity in 254 aa overlap. Contains Pfam match to entry PF01260 AP_endonucleas1, AP endonuclease family 1, and PS00726 AP endonucleases family 1 signature 1. Also similar to NMA2086, xthA (29.5% identity in 268 aa overlap); nuclease 325037..325816 Neisseria meningitidis Z2491 906354 YP_002341862.1 CDS NMA0349 NC_003116.1 325803 326147 D NMA0349, probable integral membrane protein, len: 114 aa; contains three transmembrane domain; integral membrane protein 325803..326147 Neisseria meningitidis Z2491 906355 YP_002341863.1 CDS NMA0350 NC_003116.1 326157 326687 D NMA0350, unknown, len: 176 aa; hypothetical protein 326157..326687 Neisseria meningitidis Z2491 906356 YP_002341864.1 CDS NMA0351 NC_003116.1 326780 327895 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(326780..327895) Neisseria meningitidis Z2491 906357 YP_002341865.1 CDS NMA0353 NC_003116.1 328071 328652 D NMA0353, probable integral membrane protein, len: 193 aa; some similarity to YF60_HAEIN P44253 hypothetical protein HI1560 (156 aa), fasta scores; E(): 0.0012, 28.1% identity in 128 aa overlap; integral membrane protein 328071..328652 Neisseria meningitidis Z2491 906358 YP_002341866.1 CDS NMA0354 NC_003116.1 328714 329568 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(328714..329568) Neisseria meningitidis Z2491 906359 YP_002341867.1 CDS NMA0356 NC_003116.1 330283 330789 D NMA0356, transferase, len: 168 aa; similar to e.g. TR:Q43999 (EMBL:U07639) Alcaligenes eutrophus H16 autotrophic growth (aut) gene (164 aa), fasta scores; E(): 0, 59.4% identity in 160 aa overlap, and to C-terminus of RFAE_ECOLI P76658 ADP-heptose synthase (477 aa), fasta scores; E(): 1.4e-22, 50.4% identity in 137 aa overlap. Contains Pfam match to entry PF01467 Cytidylyltransf,Cytidylyltransferase; transferase 330283..330789 Neisseria meningitidis Z2491 906360 YP_002341868.1 CDS birA NC_003116.1 330786 332564 D activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins and catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; bifunctional biotin--[acetyl-CoA-carboxylase] ligase/pantothenate kinase 330786..332564 Neisseria meningitidis Z2491 906361 YP_002341869.1 CDS NMA0358 NC_003116.1 332677 333501 D NMA0358, probable periplasmic protein, len: 274 aa. Contains N-terminal signal sequence and probable coiled-coil domain from approx aa 70-100; hypothetical protein 332677..333501 Neisseria meningitidis Z2491 906362 YP_002341870.1 CDS thiG NC_003116.1 334264 335052 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(334264..335052) Neisseria meningitidis Z2491 906364 YP_002341871.1 CDS NMA0362 NC_003116.1 335266 335460 R NMA0362, unknown, len: 64 aa; hypothetical protein complement(335266..335460) Neisseria meningitidis Z2491 906365 YP_002341872.1 CDS NMA0363 NC_003116.1 335882 336499 R NMA0363, thiE, thiamin-phosphate pyrophosphorylase,len: 205 aa; THIE_ECOLI P30137 thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) (211 aa), fasta scores; E(): 1.3e-32, 52.1% identity in 188 aa overlap. Contains PS00012 Phosphopantetheine attachment site; thiamin-phosphate pyrophosphorylase complement(335882..336499) Neisseria meningitidis Z2491 906366 YP_002341873.1 CDS NMA0364 NC_003116.1 336520 337620 R NMA0364, probable oxidoreductase, len: 366 aa; similar to e.g. TR:O34292 (EMBL:AF004408) Rhizobium etli amino acid oxidase flavoprotein thiO (327 aa),fasta scores; E(): 1.1e-23, 36.2% identity in 351 aa overlap, and GLOX_BACSU O31616 glycine oxidase (369 aa),fasta scores; E(): 1e-08, 24.3% identity in 350 aa overlap; oxidoreductase complement(336520..337620) Neisseria meningitidis Z2491 906367 YP_002341874.1 CDS NMA0365 NC_003116.1 337526 338839 R NMA0365, probable permease, len: 437 aa; similar to e.g. CODB_ECOLI P25525 cytosine permease (419 aa), fasta scores; E(): 3.8e-14, 26.0% identity in 369 aa overlap; permease complement(337526..338839) Neisseria meningitidis Z2491 906368 YP_002341875.1 CDS NMA0367 NC_003116.1 339126 340568 D NMA0367, tldD, TLDD protein homolog, len: 480 aa; TLDD_ECOLI P46473 TLDD protein (481 aa), fasta scores; E(): 0, 53.9% identity in 477 aa overlap; TLDD protein-like protein 339126..340568 Neisseria meningitidis Z2491 906370 YP_002341876.1 CDS NMA0370 NC_003116.1 342177 343565 D NMA0370, probable integral membrane protein, len: 462 aa; similar to hypothetical proteins e.g. Y325_HAEIN P44640 hypothetical protein HI0325 (450 aa), fasta scores; E(): 0, 49.8% identity in 464 aa overlap; integral membrane protein 342177..343565 Neisseria meningitidis Z2491 906373 YP_002341877.1 CDS slyX NC_003116.1 343566 343790 D NMA0371, slyX, SLYX protein homolog, len: 74 aa; simlar to SLYX_HAEIN P44759 SLYX protein homolog (73 aa),fasta scores; E(): 0.0017, 33.8% identity in 74 aa overlap, and SLYX_ECOLI P30857 SLYX protein (72 aa), fasta scores; E(): 0.24, 32.4% identity in 68 aa overlap; hypothetical protein 343566..343790 Neisseria meningitidis Z2491 906374 YP_002341878.1 CDS NMA0373 NC_003116.1 344185 344955 R NMA0373, thiF, probable ThiF protein, len: 256 aa; similar to e.g. THIF_ECOLI P30138 THIF protein (251 aa),fasta scores; E(): 0, 43.1% identity in 246 aa overlap, and MOEB_ECOLI P12282 molybdopterin biosynthesis MOEB protein. (249 aa), fasta scores; E(): 0, 43.9% identity in 244 aa overlap (note that N.m. does not have NMB_orthologues of any other molybdopterin biosynthesis proteins). Contains Pfam match to entry PF00899 ThiF_family, ThiF family; ThiF protein complement(344185..344955) Neisseria meningitidis Z2491 906376 YP_002341879.1 CDS ppc NC_003116.1 345121 347823 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 345121..347823 Neisseria meningitidis Z2491 906377 YP_002341880.1 CDS gpsA NC_003116.1 347946 348935 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 347946..348935 Neisseria meningitidis Z2491 906378 YP_002341881.1 CDS NMA0376 NC_003116.1 348990 349319 D NMA0376, unknown, len: 109 aa; contains several coiled-coil domains; hypothetical protein 348990..349319 Neisseria meningitidis Z2491 906379 YP_002341882.1 CDS NMA0377 NC_003116.1 349330 349635 D NMA0377, unknown, len: 101 aa; some similarity to YGFE_ECOLI P45580 (109 aa), fasta scores; E(): 0.00018,29.5% identity in 95 aa overlap; hypothetical protein 349330..349635 Neisseria meningitidis Z2491 906380 YP_002341883.1 CDS rplM NC_003116.1 349998 350429 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 349998..350429 Neisseria meningitidis Z2491 906381 YP_002341884.1 CDS rpsI NC_003116.1 350439 350831 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 350439..350831 Neisseria meningitidis Z2491 906382 YP_002341885.1 CDS NMA0381 NC_003116.1 351086 352015 R NMA0381, metR, probable transcriptional activator protein METR, len: 309 aa; similar to METR_HAEIN P45349 transcriptional activator protein METR (309 aa), fasta scores; E(): 0, 68.4% identity in 304 aa overlap, and METR_ECOLI P19797 transcriptional activator protein METR (317 aa), fasta scores; E(): 0, 44.0% identity in 298 aa overlap. Contains Pfam match to entry PF00126 HTH_1,Bacterial regulatory helix-turn-helix protein, lysR family, and PS00044 Bacterial regulatory proteins, lysR family signature; transcriptional activator protein METR complement(351086..352015) Neisseria meningitidis Z2491 906384 YP_002341886.1 CDS NMA0382 NC_003116.1 352146 352895 D NMA0382, unknown, len: 249 aa; similar to hypothetical proteins e.g. YBGI_HAEIN Q57354 hypothetical protein HI0105 (279 aa), fasta scores; E(): 0, 49.8% identity in 241 aa overlap; hypothetical protein 352146..352895 Neisseria meningitidis Z2491 906385 YP_002341887.1 CDS NMA0383 NC_003116.1 353018 353599 D NMA0383, petA, ubiquinol-cytochrome c reductase iron-sulfur subunit, len: 193 aa; similar to many e.g. UCRI_CHRVI O31214 ubiquinol-cytochrome c reductase iron-sulfur subunit (EC 1.10.2.2) (207 aa), fasta scores; E(): 0, 59.6% identity in 193 aa overlap. Contains Pfam match to entry PF00355 Rieske, Rieske iron-sulfur protein, and PS00200 Rieske iron-sulfur protein signature 2; ubiquinol-cytochrome c reductase iron-sulfur subunit 353018..353599 Neisseria meningitidis Z2491 906386 YP_002341888.1 CDS NMA0384 NC_003116.1 353618 354967 D NMA0384, petB, cytochrome B, len: 449 aa; similar to many e.g. CYB_CHRVI O31215 Chromatium vinosum cytochrome B (EC 1.10.2.2) (411 aa), fasta scores; E(): 0,62.9% identity in 407 aa overlap. Contains Pfam match to entry PF00033 cytochrome_b_N, Cytochrome b(N-terminal)/b6/petB, Pfam match to entry PF00032 cytochrome_b_C, Cytochrome b(C-terminal)/b6/petD, and PS00192 Cytochrome b/b6 heme-ligand signature; cytochrome B 353618..354967 Neisseria meningitidis Z2491 906387 YP_002341889.1 CDS NMA0385 NC_003116.1 354982 355770 D NMA0385, petC, cytochrome C1 precursor, len: 262 aa; similar to e.g. CY1_CHRVI O31216 cytochrome C1 precursor (244 aa), fasta scores; E(): 2.8e-27, 47.1% identity in 255 aa overlap. Contains PS00190 Cytochrome c family heme-binding site signature; cytochrome C1 precursor 354982..355770 Neisseria meningitidis Z2491 906388 YP_002341890.1 CDS NMA0386 NC_003116.1 356109 357893 D NMA0386, probable periplasmic protein, len: 594 aa; similar to YIGN_ECOLI P27850 hypothetical 54.7 kd protein (475 aa), fasta scores; E(): 0, 44.3% identity in 404 aa overlap. Contains N-terminal signal sequence and several coiled-coil domains in N-terminal half; hypothetical protein 356109..357893 Neisseria meningitidis Z2491 906389 YP_002341891.1 CDS NMA0387 NC_003116.1 358099 358731 R NMA0387, hydrolase, len: 210 aa; similar to many hypothetical proteins belonging to the glyoxalase II family e.g. YCBL_ECOLI P75849 (215 aa), fasta scores; E(): 0, 47.1% identity in 208 aa overlap. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily; hydrolase complement(358099..358731) Neisseria meningitidis Z2491 906390 YP_002341892.1 CDS NMA0388 NC_003116.1 358822 359646 D catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA; DNA ligase 358822..359646 Neisseria meningitidis Z2491 906391 YP_002341893.1 CDS hpt NC_003116.1 359715 360278 D Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 359715..360278 Neisseria meningitidis Z2491 906392 YP_002341894.1 CDS NMA0390 NC_003116.1 360359 360796 D NMA0390, probable sugar transport PTS system IIA component, len: 145 aa; simlar to e.g. PTFA_BACSU P26379 PTS system, fructose-specific IIA component (EC 2.7.1.69) (146 aa), fasta scores; E(): 0.053, 26.2% identity in 103 aa overlap, and the N-terminal domain of PTNA_ECOLI P08186 PTS system, mannose-specific IIAB component (322 aa),fasta scores; E(): 8.8e-06, 30.1% identity in 136 aa overlap; sugar transport PTS system IIA component 360359..360796 Neisseria meningitidis Z2491 906393 YP_002341895.1 CDS NMA0391 NC_003116.1 360865 361134 D NMA0391, ptsH, probable sugar transport PTS system phosphocarrier protein HPR, len: aa; similar to many e.g PTHP_ALCEU P23537 phosphocarrier protein HPR (89 aa),fasta scores; E(): 2.6e-17, 59.6% identity in 89 aa overlap. Contains Pfam match to entry PF00381 PTS-HPr, PTS HPr component phosphorylation sites, and PS00012 Phosphopantetheine attachment site; sugar transport PTS system phosphocarrier protein HPR 360865..361134 Neisseria meningitidis Z2491 906394 YP_002341896.1 CDS NMA0392 NC_003116.1 361134 362909 D NMA0392, ptsI, probable phosphoenolpyruvate-protein phosphotransferase (phosphotransferase system, enzyme I),len: aa; similar to many e.g. PT1_ALCEU P23536 phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (592 aa), fasta scores; E(): 0, 46.1% identity in 583 aa overlap. Contains 2x Pfam match to entry PF00391 PEP-utilizers, PEP-utilizing enzymes, and PS00742 PEP-utilizing enzymes signature 2; phosphoenolpyruvate-protein phosphotransferase 361134..362909 Neisseria meningitidis Z2491 906395 YP_002341897.1 CDS NMA0393 NC_003116.1 363353 364291 R NMA0393, probable ABC-transport system ATP-binding protein, len: 312 aa; similar to e.g. POTA_ECOLI P23858 spermidine/putrescine transport atp-binding protein POTA (378 aa), fasta scores; E(): 0, 44.5% identity in 281 aa overlap. Contains Pfam match to entry PF00005 ABC_tran,ABC transporter, PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature; ABC transporter ATP-binding protein complement(363353..364291) Neisseria meningitidis Z2491 906396 YP_002341898.1 CDS NMA0394 NC_003116.1 364300 365175 R NMA0394, unknown, len:291 aa; some similarity to N-terminus of TNR3_SCHPO P41888 thiamine pyrophosphokinase (569 aa), fasta scores; E(): 4.7e-18, 30.4% identity in 260 aa overlap; hypothetical protein complement(364300..365175) Neisseria meningitidis Z2491 906397 YP_002341899.1 CDS thiC NC_003116.1 365773 367674 D required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 365773..367674 Neisseria meningitidis Z2491 906400 YP_002341900.1 CDS NMA0398 NC_003116.1 369454 370443 R NMA0398, porB, porin, major outer membrane protein P.I, len: 329 aa; almost identical to many e.g. OMB2_NEIME P30688 major outer membrane protein P.IB precursor (331 aa), fasta scores; E(): 0, 94.9% identity in 331 aa overlap. Contains Pfam match to entry PF00267 Gram-ve_porins, General diffusion Gram-negative porins, and PS00576 General diffusion Gram-negative porins signature. Also similar to NMA1642, porA (43.7% identity in 398 aa overlap); porin complement(369454..370443) Neisseria meningitidis Z2491 906401 YP_002341901.1 CDS NMA0400 NC_003116.1 371688 372005 R NMA0400, chpA, PEMK-like protein, len: 105 aa; simlar to e.g. CHPA_ECOLI P33645 PEMK-like protein 1 (MAZF protein) (111 aa), fasta scores; E(): 7e-06, 38.9% identity in 72 aa overlap, and PEMK_ECOLI P13976 Plasmid IncFII R100 PEMK protein (133 aa), fasta scores; E(): 5.9e-05, 32.7% identity in 107 aa overlap; PEMK-like protein complement(371688..372005) Neisseria meningitidis Z2491 906402 YP_002341902.1 CDS NMA0401 NC_003116.1 371999 372238 R NMA0401, unknonwn, len: 79 aa; hypothetical protein complement(371999..372238) Neisseria meningitidis Z2491 906403 YP_002341903.1 CDS truA NC_003116.1 372361 373158 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(372361..373158) Neisseria meningitidis Z2491 906404 YP_002341904.1 CDS NMA0403 NC_003116.1 374566 375258 R NMA0403, unknown, len: 230 aa; almost identical to TR:AAD38302 (EMBL:AF036242) N. meningitidis NMB hypothetical 26.3 kd protein (230 aa), fasta scores; E(): 0, 97.4% identity in 230 aa overlap, and similar to TR:O28566 (EMBL:AE000985) Archaeoglobus fulgidus AF1707 (219 aa), fasta scores; E(): 5.6e-06, 25.1% identity in 215 aa overlap. Also similar to NMA0032 (53.5% identity in 230 aa overlap); hypothetical protein complement(374566..375258) Neisseria meningitidis Z2491 906405 YP_002341905.1 CDS NMA0404 NC_003116.1 375255 375998 R NMA0404, nlaB, probable 1-acyl-SN-glycerol-3-phosphate acyltransferase, len: 247 aa; identical to TR:AAD38301 (EMBL:AF036242) N. meningitidis NMB lysophosphatidic acid acyltransferase homolog (247 aa), and similar to many e.g. PLSC_BORBU Q59188 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) (250 aa), fasta scores; E(): 4e-11, 31.4% identity in 226 aa overlap. Also similar to NMA1504, plsC (23.6% identity in 148 aa overlap). Contains N-terminal signal sequence; 1-acyl-SN-glycerol-3-phosphate acyltransferase complement(375255..375998) Neisseria meningitidis Z2491 906406 YP_002341906.1 CDS NMA0405 NC_003116.1 376027 376590 R Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase complement(376027..376590) Neisseria meningitidis Z2491 906407 YP_002341907.1 CDS NMA0408 NC_003116.1 377328 378980 D NMA0408, probable integral membrane protein, len: 550 aa; highly similar to Y275_HAEIN P43975 hypothetical protein HI0275 (551 aa), fasta scores; E(): 0, 68.4% identity in 551 aa overlap; integral membrane protein 377328..378980 Neisseria meningitidis Z2491 906409 YP_002341908.1 CDS NMA0409 NC_003116.1 379050 380291 R NMA0409, probable amino-acid transport protein,len: 413 aa; similar to many e.g. MTR_ECOLI P22306 tryptophan-specific transport protein (414 aa), fasta scores; E(): 0, 47.1% identity in 408 aa overlap,TNAB_ECOLI P23173 low affinity tryptophan permease (415 aa), fasta scores; E(): 0, 43.5% identity in 409 aa overlap, and TYRP_ECOLI P18199 tyrosine-specific transport protein (403 aa), fasta scores; E(): 0, 36.9% identity in 401 aa overlap. Contains PS00594 Aromatic amino acids permeases signature; amino-acid transport protein complement(379050..380291) Neisseria meningitidis Z2491 906410 YP_002341909.1 CDS ubiG NC_003116.1 380455 381171 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 380455..381171 Neisseria meningitidis Z2491 906411 YP_002341910.1 CDS thrB NC_003116.1 381201 382124 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine; homoserine kinase 381201..382124 Neisseria meningitidis Z2491 906412 YP_002341911.1 CDS NMA0412 NC_003116.1 382463 382981 R NMA0412, probable glucokinase, len: 172 aa; similar to e.g. GNTK_SCHPO Q10242 probable gluconokinase (EC 2.7.1.12) (193 aa), fasta scores; E(): 1.8e-17, 41.5% identity in 176 aa overlap, GNTV_ECOLI P39208 thermosensitive gluconokinase (EC 2.7.1.12) (187 aa),fasta scores; E(): 2e-15, 41.8% identity in 134 aa overlap, and GNTK_ECOLI P46859 thermoresistant gluconokinase (EC 2.7.1.12) (175 aa), fasta scores; E(): 1.2e-16, 37.4% identity in 163 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); glucokinase complement(382463..382981) Neisseria meningitidis Z2491 906413 YP_002341912.1 CDS NMA0413 NC_003116.1 383001 384386 R NMA0413, gntP, probable gluconate permease, len: 461 aa; similar to many e.g. GNTP_BACSU Q9ZIJ1 gluconate permease (448 aa), fasta scores; E(): 0, 37.1% identity in 453 aa overlap; gluconate permease complement(383001..384386) Neisseria meningitidis Z2491 906414 YP_002341913.1 CDS NMA0414 NC_003116.1 384727 386319 D NMA0414, probable permease, len: 530 aa; similar to many e.g. YABK_ECOLI P31549 (536 aa), fasta scores; E(): 1.1e-14, 28.0% identity in 517 aa overlap, and MODB_ECOLI P09834 molybdenum transport system permease (229 aa), fasta scores; E(): 9.1e-12, 29.8% identity in 198 aa overlap. Contains 2x Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, and PS00402 Binding-protein-dependent transport systems inner membrane comp sign; permease 384727..386319 Neisseria meningitidis Z2491 906415 YP_002341914.1 CDS NMA0415 NC_003116.1 386348 386947 D NMA0415, unknown, len: 199 aa; similar to hypothetical proteins e.g. TR:O34872 (EMBL:AF008220) Bacillus subtilis YTIB (187 aa), fasta scores; E(): 0,55.4% identity in 184 aa overlap, and to CYNT_ECOLI P17582 carbonic anhydrase (EC 4.2.1.1) (219 aa), fasta scores; E(): 0.067, 31.5% identity in 108 aa overlap; hypothetical protein 386348..386947 Neisseria meningitidis Z2491 906416 YP_002341915.1 CDS NMA0416 NC_003116.1 386944 387537 D NMA0416, unknown, len: 197 aa; similar to many hypothetical proteins, e.g. YQEJ_BACSU P54455 (189 aa),fasta scores; E(): 1.7e-17, 35.5% identity in 203 aa overlap; hypothetical protein 386944..387537 Neisseria meningitidis Z2491 906417 YP_002341916.1 CDS NMA0417 NC_003116.1 387596 387982 D NMA0417, unknown, len: 128 aa; similar to many hypothetical proteins, e.g. YBEB_ECOLI P05848 (105 aa),fasta scores; E(): 3e-10, 36.4% identity in 110 aa overlap; hypothetical protein 387596..387982 Neisseria meningitidis Z2491 906418 YP_002341917.1 CDS NMA0418 NC_003116.1 388036 388506 D SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 388036..388506 Neisseria meningitidis Z2491 906419 YP_002341918.1 CDS NMA0419 NC_003116.1 388579 388845 D NMA0419, unknown, len: 88 aa; similar to many hypothetical proteins, e.g. YGGX_ECOLI P52065 (90 aa),fasta scores; E(): 8.2e-15, 44.3% identity in 88 aa overlap. Contains GC(6) repeat near C-terminus; hypothetical protein 388579..388845 Neisseria meningitidis Z2491 906420 YP_002341919.1 CDS NMA0420 NC_003116.1 389002 389685 D NMA0420, probable integral membrane protein, len: 227 aa; similar to many hypothetical proteins, e.g. YCCA_ECOLI P06967 (219 aa), fasta scores; E(): 2.5e-18,36.7% identity in 215 aa overlap. Contains Pfam match to entry PF01027 UPF0005, Uncharacterized protein family; integral membrane protein 389002..389685 Neisseria meningitidis Z2491 906421 YP_002341920.1 CDS coaD NC_003116.1 389809 390321 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 389809..390321 Neisseria meningitidis Z2491 906422 YP_002341921.1 CDS NMA0422 NC_003116.1 390347 391009 D NMA0422, probable psedouridine synthase, len: 220 aa; similar to hypothetical proteins e.g. Y042_HAEIN P43930 hypothetical protein HI0042 (224 aa), fasta scores; E(): 0, 51.9% identity in 214 aa overlap, and to ribosomal psedouridine synthases e.g. RLUA_ECOLI P39219 ribosomal large subunit pseudouridine synthase A (218 aa), fasta scores; E(): 9.3e-12, 33.5% identity in 182 aa overlap. Contains Pfam match to entry PF00849 YABO, Hypothetical yabO/yceC/sfhB family, and PS01129 Hypothetical yabO/yceC/sfhB family signature; psedouridine synthase 390347..391009 Neisseria meningitidis Z2491 906423 YP_002341922.1 CDS NMA0423 NC_003116.1 396694 397158 D NMA0423, DNA transport competence protein,len: 154 aa; region of similarity to SW:P39694 (CME1_BACSU) ComE a late competence operon protein from Bacillus subtilis (205 aa) fasta scores; E(): 6.2e-07,47.6% identity in 63 aa overlap. Almost identical to TR:CAB44958 (EMBL:AJ242837) ComEA protein (fragment) from Neisseria meningitidis serogroup A strain Z2491 (170 aa) fasta scores; E(): 0, 98.7% identity in 154 aa overlap. Contains Pfam match to entry PF00633 HHH,Helix-hairpin-helix motif and membrane-spanning hydrophobic region. Identical to NMA0211, and almost identical to NMA1915 (98.7% identity in 154 aa overlap), and NMA2187 (98.7% identity in 154 aa overlap); DNA transport competence protein 396694..397158 Neisseria meningitidis Z2491 906424 YP_002341923.1 CDS NMA0424 NC_003116.1 397246 397695 D NMA0424, probable pilin, len: 149 aa; similar to e.g. FMM1_NEIGO P02974 fimbrial protein precursor (pilin) (165 aa), fasta scores; E(): 0.00029, 24.7% identity in 154 aa overlap. Contains PS00409 Prokaryotic N-terminal methylation site; pilin 397246..397695 Neisseria meningitidis Z2491 906425 YP_002341924.1 CDS NMA0425 NC_003116.1 397856 398125 R NMA0425, unknown, len: 89 aa; hypothetical protein complement(397856..398125) Neisseria meningitidis Z2491 906426 YP_002341925.1 CDS NMA0427 NC_003116.1 398752 399807 D NMA0427, probable modification methylase (cytosine-specific DNA methylase), len: 351 aa; similar to many e.g. MTD2_HERAU P25265 modification methylase HgiDII (EC ) (354 aa), fasta scores; E(): 0, 39.7% identity in 345 aa overlap. Contains 2x Pfam match to entry PF00145 DNA_methylase, C-5 cytosine-specific DNA methylase; cytosine-specific DNA methylase 398752..399807 Neisseria meningitidis Z2491 906428 YP_002341926.1 CDS NMA0428 NC_003116.1 399821 401467 D NMA0428, conserved hypothetical protein, len: 560aa; similar to many of undefined function eg. SW:P25280 (YD3M_HERAU) hypothetical protein from Herpetosiphon aurantiacus (Herpetosiphon giganteus) (611 aa) fasta scores; E(): 2.6e-15, 30.1% identity in 369 aa overlap. Lies in a region of unusually low GC content. Also shows weak similarity to SW:P70754 (MUTL_AQUPY) DNA mismatch repair protein from Aquifex pyrophilus (426 aa) fasta scores; E(): 4.4, 26.4% identity in 292 aa overlap.; hypothetical protein 399821..401467 Neisseria meningitidis Z2491 906429 YP_002341927.1 CDS NMA0429 NC_003116.1 401471 401893 D NMA0429, vsr, patch repair protein, len: 140aa; similar to SW:P09184 (VSR_ECOLI) vsr, patch repair protein from Escherichia coli (156 aa) fasta scores; E(): 9.8e-21,39.3% identity in 122 aa overlap. Lies in a region of unusually low GC content.; patch repair protein 401471..401893 Neisseria meningitidis Z2491 906430 YP_002341928.1 CDS NMA0430 NC_003116.1 401916 405041 R NMA0430, DNA helicase, len: 1041aa; regions similar to many eg. SW:P43329 (HRPA_ECOLI) ATP-dependent helicase from Escherichia coli (1281 aa) fasta scores; E(): 0, 30.6% identity in 1035 aa overlap. Contains a direct degenerate repeat (408-473, 474-531) which is absent from homologues.; DNA helicase complement(401916..405041) Neisseria meningitidis Z2491 906431 YP_002341929.1 CDS NMA0431 NC_003116.1 405107 406381 R NMA0431, inner membrane protein, len: 424aa; contains membrane-spanning hydrophobic regions. Lies in a region of unusually low GC content.; inner membrane protein complement(405107..406381) Neisseria meningitidis Z2491 906432 YP_002341930.1 CDS NMA0432 NC_003116.1 406562 407689 R NMA0432, hypothetical protein, len: 375aa; hypothetical protein complement(406562..407689) Neisseria meningitidis Z2491 906433 YP_002341931.1 CDS NMA0433 NC_003116.1 407790 409181 R NMA0433, hrpA', ATP-dependent DNA helicase, len: 495aa; similar to regions of many eg. SW:P43329 (HRPA_ECOLI) hrpA, ATP-dependent DNA helicase from Escherichia coli (1281 aa) fasta scores; E(): 0, 64.5% identity in 453 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; ATP-dependent DNA helicase complement(407790..409181) Neisseria meningitidis Z2491 906434 YP_002341932.1 CDS NMA0434 NC_003116.1 409371 410780 R NMA0434, hypothetical inner membrane protein, len: 469aa; similar to SW:P37019 (YADQ_ECOLI) hypothetical protein from Escherichia coli (436 aa) fasta scores; E(): 1e-18, 29.2% identity in 449 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein complement(409371..410780) Neisseria meningitidis Z2491 906435 YP_002341933.1 CDS argJ NC_003116.1 410943 412163 R bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase complement(410943..412163) Neisseria meningitidis Z2491 906436 YP_002341934.1 CDS NMA0436 NC_003116.1 412230 412922 R NMA0436, hypothetical inner membrane protein, len: 230aa; similar to many eg. SW:P33373 (YOHK_ECOLI) hypothetical protein from Escherichia coli (231 aa) fasta scores; E(): 4.3e-26, 39.0% identity in 218 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein complement(412230..412922) Neisseria meningitidis Z2491 906437 YP_002341935.1 CDS NMA0437 NC_003116.1 412922 413266 R NMA0437, hypothetical inner membrane protein, len: 114aa; similar to many eg. SW:P39591 (YWBH_BACSU) hypothetical protein from Bacillus subtilis (128 aa) fasta scores; E(): 1.9e-07, 36.0% identity in 111 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein complement(412922..413266) Neisseria meningitidis Z2491 906438 YP_002341936.1 CDS NMA0439 NC_003116.1 413411 413629 R NMA0439, hypothetical protein, len: 72aa; hypothetical protein complement(413411..413629) Neisseria meningitidis Z2491 906440 YP_002341937.1 CDS NMA0440 NC_003116.1 413648 414490 R NMA0440, hypothetical outer membrane protein, len: 280aa; C-terminal region similar to many eg. SW:P76190 (YDHO_ECOLI) hypothetical protein from Escherichia coli (271 aa) fasta scores; E(): 1.2e-18, 50.9% identity in 116 aa overlap, similar to NMA1645 fasta scores; E(): 2.4e-20,45.8% identity in 120 aa overlap and contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family, includes several lipoproteins. N-terminal region contains 4 x EQPVLP(V/I)NR(A/V)PARRAGNADELIG(N/S)AMGL(N/L) repeat.; hypothetical outer membrane protein complement(413648..414490) Neisseria meningitidis Z2491 906441 YP_002341938.1 CDS hslO NC_003116.1 414735 415643 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 414735..415643 Neisseria meningitidis Z2491 906442 YP_002341939.1 CDS NMA0442 NC_003116.1 415729 417183 R NMA0442, hypothetical inner membrane protein, len: 484aa; similar to many proposed transporters eg. TR:P73368 (EMBL:D90905) proposed Mg2+ transporter from Synechocystis sp. (strain PCC 6803) (463 aa) fasta scores; E(): 0, 30.6% identity in 422 aa overlap. Contains two Pfam matches to entry PF00571 CBS, CBS domain.; hypothetical protein complement(415729..417183) Neisseria meningitidis Z2491 906443 YP_002341940.1 CDS NMA0444 NC_003116.1 417417 418169 R NMA0444, probable hydroxyacylglutathione hydrolase,len: 250aa; similar to many eg. SW:Q47677 (GLO2_ECOLI) probable hydroxyacylglutathione hydrolase from Escherichia coli (251 aa) fasta scores; E(): 2.6e-26, 37.5% identity in 259 aa overlap. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily.; hydroxyacylglutathione hydrolase complement(417417..418169) Neisseria meningitidis Z2491 906444 YP_002341941.1 CDS purL NC_003116.1 418264 422226 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(418264..422226) Neisseria meningitidis Z2491 906445 YP_002341942.1 CDS NMA0447 NC_003116.1 422690 423028 D NMA0447, glnB, nitrogen regulatory protein P-II 1,len: 112aa; similar to many eg. SW:P05826 (GLNB_ECOLI) glnB, nitrogen regulatory protein P-II 1 from Escherichia coli (112 aa) fasta scores; E(): 1.9e-31, 74.1% identity in 112 aa overlap. Contains Pfam match to entry PF00543 P-II, Nitrogen regulatory protein P-II; Prosite match to PS00496 P-II protein urydylation site and Prosite match to PS00638 P-II protein C-terminal region signature; nitrogen regulatory protein P-II 1 422690..423028 Neisseria meningitidis Z2491 906446 YP_002341943.1 CDS NMA0448 NC_003116.1 423084 423842 R NMA0448, probable ABC transporter ATP-binding subunit, len: 252aa; similar to many probable transporters eg. TR:P94420 (EMBL:D50453) from Bacillus subtilis (252 aa) fasta scores; E(): 0, 46.4% identity in 250 aa overlap. Contains Pfam match to entry PF00005 ABC_tran,ABC transporter; Prosite match to PS00211 ABC transporters family signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; ABC transporter ATP-binding protein complement(423084..423842) Neisseria meningitidis Z2491 906447 YP_002341944.1 CDS NMA0449 NC_003116.1 423973 424554 R NMA0449, hypothetical protein, len: 193aa; hypothetical protein complement(423973..424554) Neisseria meningitidis Z2491 906448 YP_002341945.1 CDS NMA0450 NC_003116.1 424599 425546 R NMA0450, inner membrane transport protein,len: 315aa; similar to many transport proteins eg. SW:P37737 (FATC_VIBAN) anguibactin transport protein from Vibrio anguillarum (317 aa) fasta scores; E(): 9.2e-27,29.3% identity in 307 aa overlap. Contains Pfam match to entry PF01032 FecCD_family, FecCD transport family; Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and membrane-spanning hydrophobic regions.; inner membrane transport protein complement(424599..425546) Neisseria meningitidis Z2491 906449 YP_002341946.1 CDS NMA0451 NC_003116.1 425563 426531 R NMA0451, inner membrane transport protein,len: 322aa; similar to many transport proteins eg. SW:P37738 (FATD_VIBAN) anguibactin transport protein from Vibrio anguillarum (314 aa) fasta scores; E(): 0, 38.1% identity in 310 aa overlap. Contains Pfam match to entry PF01032 FecCD_family, FecCD transport family and membrane-spanning hydrophobic regions.; inner membrane transport protein complement(425563..426531) Neisseria meningitidis Z2491 906450 YP_002341947.1 CDS NMA0452 NC_003116.1 426802 427767 R NMA0452, fetB, probable ferric enterobactin periplasmic binding protein, len: 321aa; similar to many eg. SW:P11460 (FATB_VIBAN) anguibactin binding protein from Vibrio anguillarum (322 aa) fasta scores; E(): 3.7e-22, 30.8% identity in 302 aa overlap and TR:AAD29611 (EMBL:AF115385) ferric enterobactin periplasmic binding protein from Neisseria gonorrhoeae (323 aa) fasta scores; E(): 0, 96.3% identity in 323 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site; membrane transport solute-binding protein complement(426802..427767) Neisseria meningitidis Z2491 906451 YP_002341948.1 CDS NMA0453 NC_003116.1 428465 430609 R NMA0453, fetA, probable ferric enterobactin receptor, len: 714aa; similar to many eg. TR:AAD29612 (EMBL:AF115385) FetA, ferric enterobactin receptor from Neisseria gonorrhoeae (713 aa) fasta scores; E(): 0, 95.0% identity in 714 aa overlap. Contains two Prosite match to PS01156 TonB-dependent receptor proteins signature 2.; iron-regulated outer membrane protein complement(428465..430609) Neisseria meningitidis Z2491 906452 YP_002341949.1 CDS trmE NC_003116.1 432471 433817 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(432471..433817) Neisseria meningitidis Z2491 906453 YP_002341950.1 CDS NMA0455 NC_003116.1 433948 434103 D NMA0455, hypothetical protein, len: 51aa; hypothetical protein 433948..434103 Neisseria meningitidis Z2491 906454 YP_002341951.1 CDS NMA0456 NC_003116.1 434100 434531 D NMA0456, inner membrane protein, len: 143aa; contains membrane-spanning hydrophobic regions.; inner membrane protein 434100..434531 Neisseria meningitidis Z2491 906455 YP_002341952.1 CDS NMA0457 NC_003116.1 434665 439014 D NMA0457, iga2, IgA-specific serine endopeptidase,len: 1449aa; similar to many eg. SW:P09790 (IGA_NEIGO) iga, IgA-specific serine endopeptidase from Neisseria gonorrhoeae (1532 aa) fasta scores; E(): 0, 28.8% identity in 1594 aa overlap. Contains Prosite match to PS00135 Serine proteases, trypsin family, serine active site. Also similar to NMA0905, iga (29.9% identity in 1339 aa overlap); IgA-specific serine endopeptidase 434665..439014 Neisseria meningitidis Z2491 906456 YP_002341953.1 CDS NMA0458 NC_003116.1 439330 440442 R NMA0458, transposase for insertion element IS1106A3, len: 370aa; similar to many eg. TR:CAB44967 (EMBL:AJ242841) transposase for insertion element IS1106A3 from Neisseria meningitidis serogroup A strain Z2491 (this strain) (335 aa) fasta scores; E(): 0, 84.6% identity in 370 aa overlap. Also similar to many others on this chromosome eg. NMA1115 (fasta scores; E(): 0, 85.7% identity in 370 aa overlap).; transposase for insertion element IS1106A3 complement(439330..440442) Neisseria meningitidis Z2491 906457 YP_002341954.1 CDS NMA0459 NC_003116.1 440504 441175 R NMA0459, hypothetical protein, len: 223aa; similar to TRNEW:AAD39623 (EMBL:AF069302) hypothetical protein from Pediococcus pentosaceus (231 aa) fasta scores; E(): 2.6e-27, 38.1% identity in 223 aa overlap.; hypothetical protein complement(440504..441175) Neisseria meningitidis Z2491 906458 YP_002341955.1 CDS NMA0462 NC_003116.1 441995 444811 R NMA0462, polA, DNA polymerase I, len: 938aa; similar to many eg. SW:P00582 (DPO1_ECOLI) polA, DNA polymerase I from Escherichia coli (928 aa) fasta scores; E(): 0, 52.5% identity in 946 aa overlap. Contains Pfam match to entry PF00476 DNA_pol_A, DNA polymerase family A; Pfam match to entry PF01367 5_3_exonuclease, 5'-3' exonuclease and Prosite match to PS00447 DNA polymerase family A signature.; DNA polymerase I complement(441995..444811) Neisseria meningitidis Z2491 906460 YP_002341956.1 CDS NMA0463 NC_003116.1 444957 445463 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(444957..445463) Neisseria meningitidis Z2491 906461 YP_002341957.1 CDS NMA0464 NC_003116.1 445485 445904 R NMA0464, hypothetical protein, len: 139aa; similar to SW:P44078 (Y931_HAEIN) hypothetical protein from Haemophilus influenzae (161 aa) fasta scores; E(): 7.7e-13, 40.7% identity in 123 aa overlap.; hypothetical protein complement(445485..445904) Neisseria meningitidis Z2491 906462 YP_002341958.1 CDS NMA0465 NC_003116.1 445930 446946 R NMA0465, hypothetical inner membrane protein, len: 338aa; similar to SW:P45290 (YEIH_HAEIN) hypothetical protein from Haemophilus influenzae (338 aa) fasta scores; E(): 0, 93.2% identity in 338 aa overlap. Contains membrane-spanning hydrophobic regions. Lies in a region of unusually low GC content.; hypothetical protein complement(445930..446946) Neisseria meningitidis Z2491 906463 YP_002341959.1 CDS cyaY NC_003116.1 446973 447296 R defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein complement(446973..447296) Neisseria meningitidis Z2491 906464 YP_002341960.1 CDS NMA0467 NC_003116.1 447367 447537 D NMA0467, lipoprotein, len: 56aa; similar to SW:P17323 (LPPL_PSEAE) lipopeptide from Pseudomonas aeruginosa (46 aa) fasta scores; E(): 1.2, 44.4% identity in 45 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein 447367..447537 Neisseria meningitidis Z2491 906465 YP_002341961.1 CDS NMA0468 NC_003116.1 447548 448768 D NMA0468, lysA, diaminopimelate decarboxylase, len: 406aa; similar to many eg. SW:P19572 (DCDA_PSEAE) lysA,diaminopimelate decarboxylase from Pseudomonas aeruginosa (415 aa) fasta scores; E(): 0, 59.0% identity in 400 aa overlap. Contains Pfam match to entry PF00278 Orn_DAP_Arg_deC, Pyridoxal-dependent decarboxylase and Prosite match to PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2.; diaminopimelate decarboxylase 447548..448768 Neisseria meningitidis Z2491 906466 YP_002341962.1 CDS NMA0470 NC_003116.1 448917 450452 R NMA0470, sodium-dependent inner membrane transport protein, len: 511aa; similar to many eg. SW:P44849 (Y736_HAEIN) hypothetical sodium-dependent transporter (508 aa) fasta scores; E(): 0, 59.7% identity in 506 aa overlap. Contains membrane-spanning hydrophobic regions; two Pfam matches to entry PF00209 SNF, Sodium:neurotransmitter symporter family and Prosite match to PS00610 Sodium:neurotransmitter symporter family signature 1.; sodium-dependent inner membrane transport protein complement(448917..450452) Neisseria meningitidis Z2491 906467 YP_002341963.1 CDS NMA0471 NC_003116.1 450665 451318 R NMA0471, insertion element IS1016 transposase, len: 217 aa; similar to many eg. TR:Q48234 (EMBL:X59756) insertion sequence IS1016-V6 from Haemophilus influenzae (191 aa) fasta scores; E(): 0, 70.3% identity in 175 aa overlap. Also similar to many others on this chromosome eg. NMA2185 (fasta scores; E(): 0, 97.7% identity in 217 aa overlap).; insertion element IS1016 transposase complement(450665..451318) Neisseria meningitidis Z2491 906468 YP_002341964.1 CDS groES NC_003116.1 451547 451837 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 451547..451837 Neisseria meningitidis Z2491 906469 YP_002341965.1 CDS groEL NC_003116.1 451930 453564 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 451930..453564 Neisseria meningitidis Z2491 906470 YP_002341966.1 CDS NMA0474 NC_003116.1 454152 456584 R NMA0474, hpuB, haemoglobin-haptoglobin-utilization protein, len: 810aa; strongly similar to many eg. SW:P96949 (U73112) hpuB,haemoglobin-haptoglobin-utilization protein from Neisseria meningitidis strain DNM2 (810 aa) fasta scores; E(): 0,96.5% identity in 810 aa overlap. Contains Pfam match to entry PF00593 TonB_boxC, TonB dependent receptor C-terminal region.; hemoglobin-haptoglobin-utilization protein complement(454152..456584) Neisseria meningitidis Z2491 906471 YP_002341967.1 CDS NMA0475 NC_003116.1 456615 457688 R NMA0475, hpuA, haemoglobin-haptoglobin-utilization protein, len: 357aa; similar to many eg. TR:P96948 (EMBL:U73112) hpuA, haemoglobin-haptoglobin-utilization protein from Neisseria meningitidis strain DNM2 (341 aa) fasta scores; E(): 0, 77.4% identity in 359 aa overlap.; hemoglobin-haptoglobin-utilization protein complement(456615..457688) Neisseria meningitidis Z2491 906472 YP_002341968.1 CDS NMA0476 NC_003116.1 458956 460473 D NMA0476, hypothetical periplasmic protein, len: 505aa; weakly similar to hypothetical proteins eg. TR:Q9ZF57 (EMBL:AF118122) outer membrane protein from Neisseria meningitidis (488 aa) fasta scores; E(): 5e-16, 26.3% identity in 452 aa overlap; hypothetical periplasmic protein 458956..460473 Neisseria meningitidis Z2491 906473 YP_002341969.1 CDS NMA0477 NC_003116.1 460532 462328 R NMA0477, para-aminobenzoate synthase component I, len: 598aa; regions similar to many eg. SW:P05041 (PABB_ECOLI) para-aminobenzoate synthase component I from Escherichia coli (453 aa) fasta scores; E(): 8.5e-29, 41.2% identity in 284 aa overlap. Contains Pfam match to entry PF01063 aminotran_4, Aminotransferase class IV and; para-aminobenzoate synthase component I complement(460532..462328) Neisseria meningitidis Z2491 906474 YP_002341970.1 CDS NMA0478 NC_003116.1 463713 466919 R NMA0478, outer membrane peptidase, len: 1068aa; similar to many eg. similar to a group of proteins described as outer membrane antigens or peptidases egs. SW:P31631 (SSA1_PASHA) serotype-specific antigen I from Pasteurella haemolytica (932 aa) fasta scores; E(): 5.7e-22, 26.1% identity in 509 aa overlap and SW:P09489 (PRTS_SERMA) extracellular serine protease from Serratia marcescens (1045 aa) fasta scores; E(): 1.8e-10, 23.7% identity in 1074 aa overlap. Contains two Pfam matches to entry PF00082 Peptidase_S8, Subtilase family; and Prosite match to PS00138 Serine proteases, subtilase family,serine active site.; outer membrane peptidase complement(463713..466919) Neisseria meningitidis Z2491 906475 YP_002341971.1 CDS aldA NC_003116.1 468118 469560 R NAD-linked; aldehyde dehydrogenase complement(468118..469560) Neisseria meningitidis Z2491 906476 YP_002341972.1 CDS NMA0481 NC_003116.1 469595 469795 R NMA0481, unknown, len: 66 aa; hypothetical protein complement(469595..469795) Neisseria meningitidis Z2491 906477 YP_002341973.1 CDS NMA0482 NC_003116.1 469804 470193 R NMA0482, unknown, len: 129 aa; hypothetical protein complement(469804..470193) Neisseria meningitidis Z2491 906478 YP_002341974.1 CDS NMA0483 NC_003116.1 470401 471318 R NMA0483, transcriptional regulator, len: 305aa; C-terminal region weakly similar to that of many eg. SW:Q00753 (MSMR_STRMU) msm operon regulatory protein from Streptococcus mutans (278 aa) fasta scores; E(): 9.4e-05, 30.2% identity in 96 aa overlap. Contains Pfam match to entry PF00165 HTH_2, Bacterial regulatory helix-turn-helix proteins, araC family and Prosite match to PS00041 Bacterial regulatory proteins, araC family signature.; transcriptional regulator complement(470401..471318) Neisseria meningitidis Z2491 906479 YP_002341975.1 CDS NMA0485 NC_003116.1 471431 472291 D NMA0485, probable ABC transport ATP-binding subunit, len: 286aa; similar to many eg. TR:Q9Z402 (EMBL:AF106002) toluene tolerance protein from Pseudomonas putida (269 aa) fasta scores; E(): 0, 50.8% identity in 260 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter; Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00211 ABC transporters family signature.; ABC transporter ATP binding protein 471431..472291 Neisseria meningitidis Z2491 906480 YP_002341976.1 CDS NMA0486 NC_003116.1 472339 473115 D NMA0486, ABC transport inner membrane subunit, len: 258aa; similar to many eg. TR:Q9Z401 (EMBL:AF106002) toluene tolerance protein from Pseudomonas putida (265 aa) fasta scores; E(): 0, 51.0% identity in 255 aa overlap. Lies downstream from an ABC transport ATP-binding subunit (NMA0485) and contains membrane-spanning hydrophobic regions.; ABC transporter inner membrane protein 472339..473115 Neisseria meningitidis Z2491 906481 YP_002341977.1 CDS NMA0487 NC_003116.1 473166 473660 D NMA0487, outer membrane transport protein,len: 164aa; similar to many eg. TR:Q9Z400 (EMBL:AF106002) toluene tolerance protein from Pseudomonas putida (161 aa) fasta scores; E(): 1.3e-19, 51.7% identity in 147 aa overlap. Appears to lie in an operon downstream of an ABC transporter (NMA0485 and NMA0486). Contains Contains a cleavable N-terminal signal sequence and membrane-spanning hydrophobic regions.; outer membrane transport protein 473166..473660 Neisseria meningitidis Z2491 906482 YP_002341978.1 CDS NMA0488 NC_003116.1 473697 474287 D NMA0488, periplasmic transport protein,len: 196aa; weakly similar to many eg. TR:Q9Z3Z9 (EMBL:AF106002) toluene tolerance protein from Pseudomonas putida (215 aa) fasta scores; E(): 0.0041, 24.2% identity in 211 aa overlap. Contains a cleavable N-terminal signal sequence and appears to lie in a transport operon.; periplasmic transport protein 473697..474287 Neisseria meningitidis Z2491 906483 YP_002341979.1 CDS NMA0489 NC_003116.1 474320 474622 D NMA0489, hypothetical protein, len: 100aa; similar to SW:Q57407 (YA83_HAEIN) hypothetical protein from Haemophilus influenzae (105 aa) fasta scores; E(): 0.65,29.5% identity in 88 aa overlap.; hypothetical protein 474320..474622 Neisseria meningitidis Z2491 906484 YP_002341980.1 CDS NMA0490 NC_003116.1 474619 475458 D NMA0490, periplasmic/outer membrane protein, len: 279aa; similar to many eg. SW:P43262 (VACJ_SHIFL) lipoprotein required for intercellular spreading of Shigella flexneri (251 aa) fasta scores; E(): 1.8e-14, 31.7% identity in 221 aa overlap. Seems to have a cleavable N-term signal seq.; periplasmic/outer membrane protein 474619..475458 Neisseria meningitidis Z2491 906485 YP_002341981.1 CDS NMA0491 NC_003116.1 475463 475945 D NMA0491, hypothetical protein, len: 160aa; hypothetical protein 475463..475945 Neisseria meningitidis Z2491 906486 YP_002341982.1 CDS NMA0492 NC_003116.1 475945 476328 D NMA0492, conserved hypothetical protein, len: 127aa; similar to many eg. SW:P77712 (YBAW_ECOLI) hypothetical protein from Escherichia coli (132 aa) fasta scores; E(): 3.1e-15, 40.2% identity in 127 aa overlap.; hypothetical protein 475945..476328 Neisseria meningitidis Z2491 906487 YP_002341983.1 CDS NMA0493 NC_003116.1 476325 476813 D NMA0493, periplasmic protein, len: 162aa; similar to many of undefined function eg. TR:O66542 (EMBL:AE000675) from Aquifex aeolicus (146 aa) fasta scores; E(): 1.3e-06, 32.0% identity in 128 aa overlap. Contains a cleavable N-terminal signal sequence.; hypothetical protein 476325..476813 Neisseria meningitidis Z2491 906488 YP_002341984.1 CDS NMA0494 NC_003116.1 476895 477407 R NMA0494, acetyltransferase, len: 170aa; similar to many eg. SW:P07464 (THGA_ECOLI) thiogalactoside transacetylase from Escherichia coli (203 aa) fasta scores; E(): 6.3e-10, 32.1% identity in 140 aa overlap. Contains two Pfam match to entry PF00132 hexapep,Bacterial transferase hexapeptide (four repeats).; acetyltransferase complement(476895..477407) Neisseria meningitidis Z2491 906489 YP_002341985.1 CDS rpmE NC_003116.1 477642 477857 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 477642..477857 Neisseria meningitidis Z2491 906490 YP_002341986.1 CDS NMA0496 NC_003116.1 478160 478801 D NMA0496, cad, cadmium resistance protein, len: 213aa; strongly similar to TR:O05469 (EMBL:U76550) cadD,cadmium resistance protein from Staphylococcus aureus (209 aa) fasta scores; E(): 0, 55.5% identity in 209 aa overlap. Lies in a region of unusually low GC content.; cadmium resistance protein 478160..478801 Neisseria meningitidis Z2491 906491 YP_002341987.1 CDS NMA0497 NC_003116.1 478957 480633 D NMA0497, probable inner membrane protein, len: 558aa; similar to many eg. TR:P76473 (EMBL:AE000315) hypothetical protein from Escherichia coli (550 aa) fasta scores; E(): 5.4e-05, 25.1% identity in 379 aa overlap. Contains membrane-spanning hydrophobic regions.; inner membrane protein 478957..480633 Neisseria meningitidis Z2491 906492 YP_002341988.1 CDS NMA0498 NC_003116.1 480735 481340 D NMA0498, regF, probable regulator of pilE expression, len: 201aa; similar to TR:O33374 (EMBL:X99693) regF, regulator of pilE expression from Neisseria gonorrhoeae (201 aa) fasta scores; E(): 0, 98.0% identity in 201 aa overlap and SW:P05838 (SSPA_ECOLI) stringent starvation protein A from Escherichia coli (211 aa) fasta scores; E(): 3.3e-32, 45.8% identity in 201 aa overlap. Also similar to many glutathione transferases eg. TR:O24595 (EMBL:Y12862) glutathione transferase from Zea mays (Maize) (224 aa) fasta scores; E(): 2.3e-13, 32.3% identity in 195 aa overlap. Contains Pfam match to entry PF00043 GST, Glutathione S-transferases.; regulator of pilE expression 480735..481340 Neisseria meningitidis Z2491 906493 YP_002341989.1 CDS regG NC_003116.1 481412 481804 D NMA0499, regG, regulator of pilE expression, may act in concert with regF (NMA0498) len: 130aa; similar to TR:O33375 (EMBL:X99693) regG (FRAGMENT), regulator of pilE expression from Neisseria gonorrhoeae (65 aa) fasta scores; E(): 2.6e-25, 98.5% identity in 65 aa overlap and SW:P25663 (SSPB_ECOLI) stringent starvation protein B from Escherichia coli (165 aa) fasta scores; E(): 6.7e-17, 46.6% identity in 118 aa overlap.; ClpXP protease specificity-enhancing factor 481412..481804 Neisseria meningitidis Z2491 906494 YP_002341990.1 CDS NMA0501 NC_003116.1 482129 482575 R NMA0501, conserved hypothetical protein, len: 148aa; similar to many eg. TR:P71480 (EMBL:U63641) hypothetical protein from Legionella pneumophila (146 aa) fasta scores; E(): 1.3e-19, 46.3% identity in 147 aa overlap.; hypothetical protein complement(482129..482575) Neisseria meningitidis Z2491 906496 YP_002341991.1 CDS rpsU NC_003116.1 482707 482919 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(482707..482919) Neisseria meningitidis Z2491 906497 YP_002341992.1 CDS NMA0503 NC_003116.1 483208 485058 R NMA0503, transglycosylase, len: 616aa; weakly similar to many eg. SW:P03810 (SLT_ECOLI) soluble lytic transglycosylase from Escherichia coli (645 aa) fasta scores; E(): 9.8e-21, 24.8% identity in 592 aa overlap. Contains Pfam match to entry PF01464 SLT,Transglycosylase SLT domain and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; transglycosylase complement(483208..485058) Neisseria meningitidis Z2491 906498 YP_002341993.1 CDS NMA0504 NC_003116.1 485588 486325 D NMA0504, probable ABC transport ATP-binding subunit, len: 249aa; similar to many eg. SW:P30750 (ABC_ECOLI) ATP-binding protein ABC from Escherichia coli (343 aa) fasta scores; E(): 0, 50.6% identity in 243 aa overlap. Contains Pfam match to entry PF00005 ABC_tran,ABC transporter; Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00211 ABC transporters family signature.; ABC transporter ATP-binding protein 485588..486325 Neisseria meningitidis Z2491 906499 YP_002341994.1 CDS NMA0505 NC_003116.1 486327 487013 D NMA0505, probable inner membrane transport protein,len: 228aa; similar to many eg. SW:P31547 (YAEE_ECOLI) hypothetical ABC transporter permease from Escherichia coli (217 aa) fasta scores; E(): 7e-28, 43.1% identity in 209 aa overlap. Lies immediately downstream of a ABC transport ATP-binding subunit and contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component.; inner membrane transport protein 486327..487013 Neisseria meningitidis Z2491 906500 YP_002341995.1 CDS NMA0506 NC_003116.1 487103 487966 D NMA0506, lipoprotein, len: 287aa; similar to many eg. SW:P28635 (YAEC_ECOLI) hypothetical lipoprotein from Escherichia coli (271 aa) fasta scores; E(): 4.7e-27, 39.4% identity in 277 aa overlap. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein 487103..487966 Neisseria meningitidis Z2491 906501 YP_002341996.1 CDS NMA0507 NC_003116.1 488028 488597 R NMA0507, probable decarboxylase, len: 189aa; similar to many eg. SW:P33751 (PAD1_YEAST) phenylacrylic acid decarboxylase from Saccharomyces cerevisiae (Baker's yeast) (242 aa) fasta scores; E(): 1e-30, 42.2% identity in 185 aa overlap.; aromatic acid decarboxylase complement(488028..488597) Neisseria meningitidis Z2491 906502 YP_002341997.1 CDS NMA0508 NC_003116.1 488755 489615 D NMA0508, chromosome segregation proteins,len: 286aa; similar to many eg. SW:P26497 (SP0J_BACSU) stage 0 sporulation protein from Bacillus subtilis (282 aa) fasta scores; E(): 0, 41.3% identity in 286 aa overlap. Contains helix-turn-helix motifs 132-153aa (+5.12 SD) and 143-164aa (+5.01 SD).; chromosome segregation proteins 488755..489615 Neisseria meningitidis Z2491 906503 YP_002341998.1 CDS NMA0510 NC_003116.1 489750 490088 D NMA0510, hypothetical protein, len: 112aa; contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a helix-turn-helix motif 32-53aa (+2.63 SD).; hypothetical protein 489750..490088 Neisseria meningitidis Z2491 906504 YP_002341999.1 CDS NMA0511 NC_003116.1 490197 490961 D NMA0511, insertion element IS1655 transposase, len: 254aa; similar to many eg. SW:P37247 (TRA4_BACFR) insertion element IS4351 transposase from Bacteroides fragilis (326 aa) fasta scores; E(): 3e-29, 38.5% identity in 252 aa overlap. Also similar to many others on this chromosome eg. NMA1486 (fasta scores; E(): 0, 100.0% identity in 254 aa overlap). Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family. Contains helix-turn-helix motif 22-43aa (+4.99 SD).; insertion element IS1655 transposase 490197..490961 Neisseria meningitidis Z2491 906505 YP_002342000.1 CDS NMA0512 NC_003116.1 491540 491893 D NMA0512, atpI, probable ATP synthase I, inner membrane protein, len: 117aa; weakly similar to many eg. SW:P03808 (ATPZ_ECOLI) atpI, probable ATP synthase I from Escherichia coli (125 aa) fasta scores; E(): 0.93, 25.5% identity in 102 aa overlap. Contains membrane-spanning hydrophobic regions.; ATP synthase I 491540..491893 Neisseria meningitidis Z2491 906506 YP_002342001.1 CDS atpB NC_003116.1 491883 492749 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 491883..492749 Neisseria meningitidis Z2491 906507 YP_002342002.1 CDS atpE NC_003116.1 492806 493042 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 492806..493042 Neisseria meningitidis Z2491 906508 YP_002342003.1 CDS atpF NC_003116.1 493113 493583 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 493113..493583 Neisseria meningitidis Z2491 906509 YP_002342004.1 CDS atpH NC_003116.1 493588 494121 D produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 493588..494121 Neisseria meningitidis Z2491 906510 YP_002342005.1 CDS atpA NC_003116.1 494132 495679 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 494132..495679 Neisseria meningitidis Z2491 906511 YP_002342006.1 CDS atpG NC_003116.1 495704 496579 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 495704..496579 Neisseria meningitidis Z2491 906512 YP_002342007.1 CDS atpD NC_003116.1 496617 498014 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 496617..498014 Neisseria meningitidis Z2491 906513 YP_002342008.1 CDS atpC NC_003116.1 498025 498447 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 498025..498447 Neisseria meningitidis Z2491 906514 YP_002342009.1 CDS glyQ NC_003116.1 498802 499707 D glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 498802..499707 Neisseria meningitidis Z2491 906515 YP_002342010.1 CDS NMA0522 NC_003116.1 499784 500194 D NMA0522, hypothetical protein, len: 136aa; similar to SW:P44649 (YGGL_HAEIN) hypothetical protein from Haemophilus influenzae (114 aa) fasta scores; E(): 0.015,32.1% identity in 106 aa overlap.; hypothetical protein 499784..500194 Neisseria meningitidis Z2491 906516 YP_002342011.1 CDS glyS NC_003116.1 500215 502278 D glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 500215..502278 Neisseria meningitidis Z2491 906517 YP_002342012.1 CDS NMA0524 NC_003116.1 502343 503383 D NMA0524, lgtA, lacto-N-neotetraose biosynthesis glycosyl tranferase, len: 346 aa; highly similar to TR:Q51115 (EMBL:U25839), lgtA, Neisseria meningitidis lacto-N-neotetraose biosynthesis glycosyl tranferase (333 aa), fasta scores; E(): 0, 94.3% identity in 333 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; lacto-N-neotetraose biosynthesis glycosyl transferase 502343..503383 Neisseria meningitidis Z2491 906518 YP_002342013.1 CDS NMA0525 NC_003116.1 503383 504222 D NMA0525, lgtB, lacto-N-neotetraose biosynthesis glycosyl tranferase, len:279 aa; highly similar to SW:LGTB_NEIME (EMBL:U25839), lgtB, Neisseria meningitidis MC58 lacto-N-neotetraose biosynthesis glycosyl tranferase (275 aa), fasta scores; E(): 0, 92.5% identity in 279 aa overlap. Highly similar to NMA0527, fasta scores; E(): 0,75.7% identity in 280 aa overlap; lacto-N-neotetraose biosynthesis glycosyl transferase 503383..504222 Neisseria meningitidis Z2491 906519 YP_002342014.1 CDS NMA0527 NC_003116.1 504371 505177 D NMA0527, lgtB2, lacto-N-neotetraose biosynthesis glycosyl tranferase, len: 268 aa; highly similar to SW:LGTB_NEIME (EMBL:U25839), lgtB, Neisseria meningitidis MC58 lacto-N-neotetraose biosynthesis glycosyl tranferase (275 aa), fasta scores; E(): 0, 72.9% identity in 280 aa overlap. Highly similar to NMA0525, fasta scores; E(): 0,75.7% identity in 280 aa overlap; lacto-N-neotetraose biosynthesis glycosyl transferase 504371..505177 Neisseria meningitidis Z2491 906521 YP_002342015.1 CDS NMA0528 NC_003116.1 507126 507851 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(507126..507851) Neisseria meningitidis Z2491 906522 YP_002342016.1 CDS NMA0529 NC_003116.1 508060 508854 D NMA0529, len: 264 aa; unknown, similar to SW:SUHB_ECOLI (EMBL:M34828), suhB, Escherichia coli protein which affects sigma 32 synthesis (267 aa), fasta scores; E(): 4e-18, 34.8% identity in 184 aa overlap and to homologues from other bacteria. Also similar to eukaryotic myo-inositol-1(or 4)-monophosphatases e.g. SW:MYOP_RAT (EMBL:U84038), impA1, Rattus norvegicus myo-inositol-1(or 4)-monophosphatase (277 aa), fasta scores; E(): 4.2e-17, 34.8% identity in 204 aa overlap. Also similar to NMA1559, fasta scores; E(): 5e-19, 35.2% identity in 179 aa overlap. Contains Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family and PS00629 Inositol monophosphatase family signature 1; hypothetical protein 508060..508854 Neisseria meningitidis Z2491 906523 YP_002342017.1 CDS fabG NC_003116.1 512369 513115 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(512369..513115) Neisseria meningitidis Z2491 906529 YP_002342018.1 CDS guaA NC_003116.1 513177 514742 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(513177..514742) Neisseria meningitidis Z2491 906530 YP_002342019.1 CDS NMA0535 NC_003116.1 514842 516707 R NMA0535, probable ABC transporter ATP-binding protein, len: 621 aa; similar to many e.g. SW:MSBA_ECOLI (EMBL:Z11796), msbA, Escherichia coli essential ABC transporter involved in lipid A and phospholipid biosynthesis (582 aa), fasta scores; E(): 0, 35.2% identity in 597 aa overlap. Contains Pfam matches to entry PF00664 ABC_membrane, ABC transporter transmembrane region and to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Contains hydrophobic, probable membrane-spanning regions; ABC transporter ATP-binding protein complement(514842..516707) Neisseria meningitidis Z2491 906531 YP_002342020.1 CDS NMA0536 NC_003116.1 516845 517771 R NMA0536, fabD, probable malonyl CoA-acyl carrier protein transacylase, len: 308 aa; similar to many e.g. SW:FABD_ECOLI (EMBL:M87040), fabD, Escherichia coli malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (308 aa), fasta scores; E(): 0, 57.0% identity in 305 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain; malonyl CoA-acyl carrier protein transacylase complement(516845..517771) Neisseria meningitidis Z2491 906532 YP_002342021.1 CDS NMA0537 NC_003116.1 517957 518322 R NMA0537, integral membrane protein, len: 121 aa; unknown, in part similar to TR:P94519 (EMBL:Z75208), ysdA, Bacillus subtilis hypothetical protein (89 aa), fasta scores; E(): 3.1e-05, 39.3% identity in 84 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein complement(517957..518322) Neisseria meningitidis Z2491 906533 YP_002342022.1 CDS fabH NC_003116.1 518369 519331 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase complement(518369..519331) Neisseria meningitidis Z2491 906534 YP_002342023.1 CDS NMA0540 NC_003116.1 519581 520006 R NMA0540, len: 141 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(519581..520006) Neisseria meningitidis Z2491 906535 YP_002342024.1 CDS NMA0541 NC_003116.1 520024 520275 R NMA0541, len: 83 aa, unknown, lies within a region of unusually low GC content; hypothetical protein complement(520024..520275) Neisseria meningitidis Z2491 906536 YP_002342025.1 CDS plsX NC_003116.1 520411 521466 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX complement(520411..521466) Neisseria meningitidis Z2491 906537 YP_002342026.1 CDS NMA0543 NC_003116.1 521554 522081 R NMA0543, len: 175 aa; shows very weak similarity to TR:P74916 (EMBL:D37928), gpt, Thermus aquaticus purine phosphoribosyltransferase (154 aa), fasta scores; E(): 8.7e-05, 27.8% identity in 158 aa overlap and to hypothetical proteins e.g. TR:CAB49024 (EMBL:AJ248283) purine phosphoribosyltransferase related protein (153 aa),fasta scores; E(): 2.5e-09, 30.1% identity in 163 aa overlap; hypothetical protein complement(521554..522081) Neisseria meningitidis Z2491 906538 YP_002342027.1 CDS rpmF NC_003116.1 522409 522588 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(522409..522588) Neisseria meningitidis Z2491 906539 YP_002342028.1 CDS NMA0545 NC_003116.1 522622 523125 R NMA0545, len: 167 aa; unknown, shows weak similarity to SW:YCED_ECOLI (EMBL:M29698), yceD,Escherichia coli hypothetical protein (17=3 aa), fasta scores; E(): 1.3e-07, 32.0% identity in 172 aa overlap and SW:YCED_HAEIN (EMBL:U20229), HI0159, Haemophilus influenzae hypothetical protein (174 aa), fasta scores; E(): 4.5e-06,30.6% identity in 173 aa overlap; hypothetical protein complement(522622..523125) Neisseria meningitidis Z2491 906540 YP_002342029.1 CDS maf NC_003116.1 523273 523863 D Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 523273..523863 Neisseria meningitidis Z2491 906541 YP_002342030.1 CDS NMA0547 NC_003116.1 523910 524635 D NMA0547, len: 241 aa; unknown, similar to many hypothetical proteins e.g. SW:YRAL_ECOLI (EMBL:U18997),yraL, Escherichia coli hypothetical protein (286 aa),fasta scores; E(): 5.6e-14, 31.1% identity in 235 aa overlap. Also similar to NMA0342, fasta scores; E(): 1.6e-14, 30.4% identity in 217 aa overlap; hypothetical protein 523910..524635 Neisseria meningitidis Z2491 906542 YP_002342031.1 CDS NMA0548 NC_003116.1 524716 526353 R functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC complement(524716..526353) Neisseria meningitidis Z2491 906543 YP_002342032.1 CDS NMA0549 NC_003116.1 526525 526815 R NMA0549, len: 96 aa; unknown, similar to hypothetical proteins found downstream of rnpA and elsewhere in many bacteria e.g. SW:YIDD_ECOLI (EMBL:M11056), yidD, Escherichia coli hypothetical protein (85 aa), fasta scores; E(): 3.1e-14, 52.9% identity in 68 aa overlap. Also similar to TR:Q44066 (EMBL:L36462), hlyA,Aeromonas hydrophila haemolysin (85 aa), fasta scores; E(): 3.1e-14, 52.9% identity in 68 aa overlap. GC frameplot suggests a start codon overlapping the stop codon of rnpA. However, similarity to other sequences suggests a start codon at codon 24 or 28. The true position is therefore uncertain; hypothetical protein complement(526525..526815) Neisseria meningitidis Z2491 906544 YP_002342033.1 CDS rnpA NC_003116.1 526812 527177 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(526812..527177) Neisseria meningitidis Z2491 906545 YP_002342034.1 CDS rpmH NC_003116.1 527180 527314 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(527180..527314) Neisseria meningitidis Z2491 906546 YP_002342035.1 CDS dnaA NC_003116.1 527602 529158 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 527602..529158 Neisseria meningitidis Z2491 906547 YP_002342036.1 CDS dnaN NC_003116.1 529238 530341 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 529238..530341 Neisseria meningitidis Z2491 906548 YP_002342037.1 CDS NMA0554 NC_003116.1 530526 531119 R NMA0554, transposase for IS1016, len: 197 aa; similar to many e.g. TR:Q48234 (EMBL:X59756) ORF from Haemophilus influenzae insertion sequence IS1016-V6 (191 aa), fasta scores; E(): 0, 69.7% identity in 175 aa overlap; transposase for IS1016 complement(530526..531119) Neisseria meningitidis Z2491 906549 YP_002342038.1 CDS ppk NC_003116.1 531352 533409 R catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase complement(531352..533409) Neisseria meningitidis Z2491 906550 YP_002342039.1 CDS NMA0556 NC_003116.1 533578 534021 R NMA0556, periplasmic protein, len: 147 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein complement(533578..534021) Neisseria meningitidis Z2491 906551 YP_002342040.1 CDS NMA0557 NC_003116.1 534028 534543 R NMA0557, mlp, lipoprotein, len: 171 aa; highly similar to TR:Q51103 (EMBL:U16284), mlp, Neisseria meningitidis BNCV lipoprotein not expressed by Neisseria gonorrhoeae (171 aa), fasta scores; E(): 0, 97.1% identity in 171 aa overlap. Contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein complement(534028..534543) Neisseria meningitidis Z2491 906552 YP_002342041.1 CDS leuS NC_003116.1 534813 537545 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 534813..537545 Neisseria meningitidis Z2491 906553 YP_002342042.1 CDS NMA0560 NC_003116.1 537775 538566 D NMA0560, drg, probable type II restriction endonuclease, len: 263 aa; similar to SW:T2D1_STRPN (EMBL:M14340), dpnC, Streptococcus pneumoniae type II restriction endonuclease (254 aa), fasta scores; E(): 0,43.4% identity in 256 aa overlap. Highly similar to TR:AAD34293 (EMBL:AF091143), drg, Neisseria meningitidis BL2 endonuclease (254 aa), fasta scores; E(): 0,100.0% identity in 252 aa overlap. Lies within a region of unusually low GC content; type II restriction endonuclease 537775..538566 Neisseria meningitidis Z2491 906554 YP_002342043.1 CDS NMA0562 NC_003116.1 538898 539779 D NMA0562, len: 293 aa; unknown, shows weak similarity, except at the N-terminus, to hypothetical proteins from bacteria and yeast e.g. SW:YGGG_ECOLI (EMBL:M32363), yggG, Escherichia coli hypothetical protein (252 aa), fasta scores; E(): 1.3e-07 23.4% identity in 256 aa overlap. The predicted start codon is uncertain; fasta similarities and GC frameplot suggest that the start codon would be at approx. codon 17 where a potential signal sequence and lipoprotein attachment site would then be predicted. As no candidate sites are present, the nearest upstream alternative has been used. Lies within a region of unusually low GC content; hypothetical protein 538898..539779 Neisseria meningitidis Z2491 906556 YP_002342044.1 CDS NMA0564 NC_003116.1 540161 540472 R NMA0564, DNA-binding protein, len: 103 aa; unknown, similar to TR:Q57459 (EMBL:X75356) Coxiella burnetii plasmid QpH1 hypothetical protein (114 aa), fasta scores; E(): 3.5e-15, 49.0% identity in 96 aa overlap. Contains Pfam match to entry PF01381 HTH_3,Helix-turn-helix. Contains probable helix-turn-helix motif at aa 58-79 (Score 1781, +5.25 SD); DNA-binding protein complement(540161..540472) Neisseria meningitidis Z2491 906558 YP_002342045.1 CDS NMA0565 NC_003116.1 540469 540837 R NMA0565, len: 122 aa; unknown, similar to TR:Q45933 (EMBL:X85964) Coxiella burnetii plasmid QpDV hypothetical protein (121 aa), fasta scores; E(): 3.5e-14, 39.2% identity in 120 aa overlap; hypothetical protein complement(540469..540837) Neisseria meningitidis Z2491 906559 YP_002342046.1 CDS secG NC_003116.1 541736 542086 R NMA0569, secG, probable protein-export integral membrane protein, len: 116 aa; similar to SW:SECG_ECOLI (EMBL:D16463), secG, Escherichia coli protein-export membrane protein (110 aa), fasta scores; E(): 2.9e-09,38.6% identity in 101 aa overlap. Contains a probable N-terminal signal sequence and a hydrophobic, probable membrane-spanning region; preprotein translocase subunit SecG complement(541736..542086) Neisseria meningitidis Z2491 906562 YP_002342047.1 CDS tpiA NC_003116.1 542093 542848 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(542093..542848) Neisseria meningitidis Z2491 906563 YP_002342048.1 CDS NMA0571 NC_003116.1 543026 543553 D NMA0571, len: 175 aa; unknown, similar to hypothetical proteins from bacteria and eukaryotes e.g. SW:YKG9_YEAST (EMBL:X75780), YKL069W, Saccharomyces cerevisiae hypothetical protein (180 aa), fasta scores; E(): 1.3e-20, 37.7% identity in 167 aa overlap and SW:YEBR_ECOLI (EMBL:AE000277), yebR, Escherichia coli hypothetical protein (183 aa), fasta scores; E(): 1.4e-20,44.0% identity in 150 aa overlap; hypothetical protein 543026..543553 Neisseria meningitidis Z2491 906564 YP_002342049.1 CDS NMA0572 NC_003116.1 543655 544311 D NMA0572, probable protein-L-isoaspartate O-methyltransferase, len: 218 aa; similar to many e.g. SW:PIMT_ECOLI (EMBL:M63493), pcm, Escherichia coli protein-L-isoaspartate O-methyltransferase (EC 2.1.1.77) (207 aa), fasta scores; E(): 1.5e-17, 38.7% identity in 186 aa overlap. Contains Pfam match to entry PF01135 PCMT,Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); protein-L-isoaspartate O-methyltransferase 543655..544311 Neisseria meningitidis Z2491 906565 YP_002342050.1 CDS NMA0573 NC_003116.1 544391 544714 D NMA0573, len: 107 aa; unknown, shows weak similarity SW:GLPE_ECOLI (EMBL:M96795), glpE, Escherichia coli protein of unknown function (108 aa), fasta scores; E(): 4.6e-06, 31.8% identity in 85 aa overlap and to other hypothetical protein of similar length. Also shows weak similarity to the C-termini of longer hypothetical proteins e.g. TR:O05860 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical protein (392 aa), fasta scores; E(): 8.9e-10, 39.0% identity in 100 aa overlap. Contains Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain; hypothetical protein 544391..544714 Neisseria meningitidis Z2491 906566 YP_002342051.1 CDS NMA0575 NC_003116.1 545129 547306 R NMA0575, probable ferric siderophore receptor protein, len: 725 aa; similar to many ferric siderophore receptors e.g. TR:AAD26430 (EMBL:AF135154), fauA,Bordetella pertussis FERRIC alcaligin siderophore receptor (734 aa), fasta scores; E(): 0, 33.1% identity in 721 aa overlap. Contains Pfam match to entry PF00593 TonB_boxC,TonB dependent receptor C-terminal region. Contains a probable N-terminal signal sequence; ferric siderophore receptor protein complement(545129..547306) Neisseria meningitidis Z2491 906568 YP_002342052.1 CDS NMA0576 NC_003116.1 547420 547743 R NMA0576, len: 107 aa; unknown, shows weak similarity to TR:P96597 (EMBL:AB001488), ydbB, Bacillus subtilis hypothetical protein (113 aa), fasta scores; E(): 2.7e-05, 33.3% identity in 66 aa overlap; hypothetical protein complement(547420..547743) Neisseria meningitidis Z2491 906569 YP_002342053.1 CDS NMA0577 NC_003116.1 548781 549746 R NMA0577, fetB2, probable ferric enterobactin transporter binding protein, len: 321 aa; similar to TR:AAD29611 (EMBL:AF115385), fetB, Neisseria gonorrhoeae ferric enterobactin transporter periplasmic binding protein (323 aa), fasta scores; E(): 0, 50.6% identity in 314 aa overlap. Contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Similar to NMA0452, fasta scores; E(): 0, 50.0% identity in 314 aa overlap; ferric enterobactin transporter binding protein complement(548781..549746) Neisseria meningitidis Z2491 906570 YP_002342054.1 CDS NMA0578 NC_003116.1 549982 550938 D NMA0578, araC-family transcriptional regulator, len: 318 aa; shows similarity to known transcriptional regulators only at the C-terminus, in the helix-turn-helix region e.g. TR:O52834 (EMBL:AJ000061), alcR, Bordetella bronchiseptica regulator of alcaligin siderophore synthesis (303 aa), fasta scores; E(): 5.2e-06, 32.9% identity in 140 aa overlap. Contains a probable helix-turn-helix motif at aa 236-257 (Score 2068,+6.23 SD). Contains Pfam match to entry PF00165 HTH_2,Bacterial regulatory helix-turn-helix proteins, araC family; araC-family transcriptional regulator 549982..550938 Neisseria meningitidis Z2491 906571 YP_002342055.1 CDS NMA0579 NC_003116.1 551052 553067 R NMA0579, prolyl endopeptidase, len: 671 aa; shows weak similarity to known prolyl endopeptidases e.g. SW:PPCE_AERHY (EMBL:D14005) Aeromonas hydrophila prolyl endopeptidase (EC 3.4.21.26) (689 aa), fasta scores; E(): 3.5e-31, 25.5% identity in 666 aa overlap and SW:PPCF_FLAME (EMBL:M81461) Flavobacterium meningosepticum prolyl endopeptidase precursor (EC 3.4.21.26) (705 aa),fasta scores; E(): 1.8e-28, 24.7% identity in 684 aa overlap. Contains Pfam match to entry PF00326 Peptidase_S9, Prolyl oligopeptidase family; prolyl endopeptidase complement(551052..553067) Neisseria meningitidis Z2491 906572 YP_002342056.1 CDS argA NC_003116.1 553268 554578 R catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase complement(553268..554578) Neisseria meningitidis Z2491 906573 YP_002342057.1 CDS NMA0581 NC_003116.1 554575 555009 R NMA0581, len: 144 aa; unknown; hypothetical protein complement(554575..555009) Neisseria meningitidis Z2491 906574 YP_002342058.1 CDS pyrE NC_003116.1 555083 555724 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(555083..555724) Neisseria meningitidis Z2491 906575 YP_002342059.1 CDS NMA0583 NC_003116.1 555786 556523 R NMA0583, len: 245 aa; unknown; hypothetical protein complement(555786..556523) Neisseria meningitidis Z2491 906576 YP_002342060.1 CDS NMA0584 NC_003116.1 556517 556957 R NMA0584, acetyltransferase, len: 146 aa; shows weak similarity to SW:RIMI_ECOLI (EMBL:X06117),rimI, Escherichia coli ribosomal-protein-alanine acetyltransferase (148 aa), fasta scores; E(): 1.4e-11,40.8% identity in 120 aa overlap. Also similar to hypothetical acetyltransferases. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; acetyltransferase complement(556517..556957) Neisseria meningitidis Z2491 906577 YP_002342061.1 CDS NMA0585 NC_003116.1 556954 557631 R NMA0585, len: 225 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YEAZ_ECOLI (EMBL:AE000275),yeaZ, Escherichia coli hypothetical protein (231 aa),fasta scores; E(): 6.7e-13, 35.2% identity in 227 aa overlap; hypothetical protein complement(556954..557631) Neisseria meningitidis Z2491 906578 YP_002342062.1 CDS NMA0586 NC_003116.1 557771 558613 R NMA0586, lipoprotein, len: 280 aa; unknown, contains a N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein complement(557771..558613) Neisseria meningitidis Z2491 906579 YP_002342063.1 CDS fba NC_003116.1 558939 560003 R class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase complement(558939..560003) Neisseria meningitidis Z2491 906580 YP_002342064.1 CDS NMA0588 NC_003116.1 560197 561114 D NMA0588, xerC, probable integrase/recombinase, len: 305 aa; similar to many e.g. SW:XERC_ECOLI (EMBL:M87049),xerC, Escherichia coli integrase/recombinase (298 aa),fasta scores; E(): 0, 43.7% identity in 300 aa overlap. Similar to NMA0964, fasta scores; E(): 4.4e-28, 35.0% identity in 294 aa overlap. Contains Pfam match to entry PF00589 Phage_integrase, 'Phage' integrase family; integrase/recombinase 560197..561114 Neisseria meningitidis Z2491 906581 YP_002342065.1 CDS dxs NC_003116.1 561199 563112 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 561199..563112 Neisseria meningitidis Z2491 906582 YP_002342066.1 CDS NMA0590 NC_003116.1 563197 564525 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(563197..564525) Neisseria meningitidis Z2491 906583 YP_002342067.1 CDS hemL NC_003116.1 565358 566641 D Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 565358..566641 Neisseria meningitidis Z2491 906585 YP_002342068.1 CDS orn NC_003116.1 567140 567703 R 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease complement(567140..567703) Neisseria meningitidis Z2491 906586 YP_002342069.1 CDS prmA NC_003116.1 567721 568608 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase complement(567721..568608) Neisseria meningitidis Z2491 906587 YP_002342070.1 CDS NMA0596 NC_003116.1 568869 570230 R NMA0596, accC, probable acetyl-CoA carboxylase biotin carboxylase component, len: 453 aa; similar to many e.g. SW:ACCC_PSEAE (EMBL:L14612), accC, Pseudomonas aeruginosa biotin carboxylase (EC 6.3.4.14) (449 aa),fasta scores; E(): 0, 68.2% identity in 444 aa overlap. Contains Pfam match to entry PF00289 CPSase_L_chain,Carbamoyl-phosphate synthase (CPSase), PS00866 Carbamoyl-phosphate synthase subdomain signature 1 and PS00867 Carbamoyl-phosphate synthase subdomain signature 2; acetyl-CoA carboxylase biotin carboxylase component complement(568869..570230) Neisseria meningitidis Z2491 906588 YP_002342071.1 CDS accB NC_003116.1 570343 570798 R composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit complement(570343..570798) Neisseria meningitidis Z2491 906590 YP_002342072.1 CDS queA NC_003116.1 571154 572194 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 571154..572194 Neisseria meningitidis Z2491 906592 YP_002342073.1 CDS NMA0600 NC_003116.1 572565 573143 R NMA0600, len: 192 aa; unknown, similar to SW:MDAB_ECOLI (EMBL:U18656), mdaB, Escherichia coli modulator of drug activity B ( modulator of topoisomerase IV activity imparting DMP 840, adriamycin and etoposide resistance on overexpression) (193 aa),fasta scores; E(): 0, 59.2% identity in 191 aa overlap. Also similar to hypothetical proteins from bacteria and Schizosaccharomyces pombe e.g. SW:YA05_SCHPO (EMBL:Z49811), SPAC5H10.05C, Schizosaccharomyces pombe hypothetical protein (196 aa), E(): 0, 55.7% identity in 192 aa overlap. Identical, except at the N-terminus, to NMA1174, fasta scores; E(): 0, 99.3% identity in 147 aa overlap; hypothetical protein complement(572565..573143) Neisseria meningitidis Z2491 906593 YP_002342074.1 CDS NMA0601 NC_003116.1 573382 574281 D NMA0601, probable lysR-family transcriptional regulator, len: 299 aa; similar to many e.g. TR:P72131 (EMBL:U35068), ptxR, Pseudomonas aeruginosa positive regulator of exotoxin A production (312 aa), fasta scores; E(): 7.4e-24, 31.9% identity in 295 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and PS00044 Bacterial regulatory proteins, lysR family signature. Contains probable helix-turn-helix motif at aa 19-40 (Score 1196, +3.26 SD); lysR-family transcriptional regulator 573382..574281 Neisseria meningitidis Z2491 906594 YP_002342075.1 CDS carB NC_003116.1 574508 577723 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(574508..577723) Neisseria meningitidis Z2491 906596 YP_002342076.1 CDS NMA0603 NC_003116.1 577730 578278 R NMA0603, len: 182 aa; unknown, lies within a region of unusually low GC content. Shows weak similarity to NMA2217, fasta scores; E(): 4.4e-05, 23.8% identity in 185 aa overlap; hypothetical protein complement(577730..578278) Neisseria meningitidis Z2491 906597 YP_002342077.1 CDS NMA0604 NC_003116.1 578281 578844 R NMA0604, len: 187 aa; unknown, shows very weak similarity to the C-termini of SW:CMF3_BACSU (EMBL:Z18629), comFC, Bacillus subtilis competence protein (229 aa), fasta scores; E(): 0.077, 25.3% identity in 150 aa overlap and TR:AAD36651 (EMBL:AE001803), TM1584,Thermotoga maritima competence protein (202 aa),fasta scores; E(): 0.003, 26.1% identity in 142 aa overlap. Lies within a region of unusually low GC content; hypothetical protein complement(578281..578844) Neisseria meningitidis Z2491 906598 YP_002342078.1 CDS NMA0605 NC_003116.1 579695 580084 R NMA0605, len: 129 aa; unknown, similar to ORFs present between the carA and carB genes of other Neisseria spp. e.g. TR:Q9ZIE8 (EMBL:AF029362) Neisseria gonorrhoeae ORF (129 aa), fasta scores; E(): 0, 91.5% identity in 129 aa overlap and to CDS from other bacteria e.g. SW:YCJD_ECOLI (EMBL:AE000227), ycjD, Escherichia coli hop (117 aa), fasta scores; E(): 1.7e-20, 46.0% identity in 113 aa overlap; hypothetical protein complement(579695..580084) Neisseria meningitidis Z2491 906599 YP_002342079.1 CDS NMA0606 NC_003116.1 580081 580260 R NMA0606, len: 59 aa; unknown; hypothetical protein complement(580081..580260) Neisseria meningitidis Z2491 906600 YP_002342080.1 CDS NMA0607 NC_003116.1 580363 580500 R NMA0607, len: 45 aa; unknown, highly similar to part of TR:Q50992 (EMBL:L36381), sucA, Neisseria gonorrhoeae 2-oxoglutarate dehydrogenase E1 component (partial CDS) (582 aa), fasta scores; E(): 8.4e-17, 93.0% identity in 43 aa overlap. Up to codon 87 in TR:Q50992 the sequence is markedly different from other sucA homologues, including sucA from this strain; hypothetical protein complement(580363..580500) Neisseria meningitidis Z2491 906602 YP_002342081.1 CDS carA NC_003116.1 580546 581679 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(580546..581679) Neisseria meningitidis Z2491 906603 YP_002342082.1 CDS NMA0609 NC_003116.1 583916 587029 R NMA0609, pilC1, pilus-associated protein, len: 1037; highly similar to many other pilus-associated proteins from Neisseris spp. e.g. TR:O05924 (EMBL:Y13020),pilC1 from Neisseria meningitidis FAM20 (1038 aa), fasta scores; E(): 0, 78.0% identity in 1043 aa overlap. Contains 2 PS00017 ATP/GTP-binding site motif A (P-loop); pilus-associated protein complement(583916..587029) Neisseria meningitidis Z2491 906604 YP_002342083.1 CDS NMA0611 NC_003116.1 587959 589038 R NMA0611, len: 375 aa; unknown, similar to many hypothetical proteins from both bacteria and eukaryotes e.g. SW:MRP_ECOLI (EMBL:U00007), mrp, Escherichia coli hypothetical protein (379 aa), fasta scores; E(): 0, 45.2% identity in 372 aa overlap. Contains a region similar to NMA0076, fasta scores; E(): 1.2e-06, 24.1% identity in 266 aa overlap and NMA0100, fasta scores; E(): 2.4e-05, 26.3% identity in 262 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein complement(587959..589038) Neisseria meningitidis Z2491 906606 YP_002342084.1 CDS NMA0612 NC_003116.1 589403 589912 D NMA0612, periplasmic thioredoxin, len: 169 aa; similar to many e.g. shows weak similarity to SW:CCMG_PARDE (EMBL:Z71971), ccmG, Paracoccus denitrificans periplasmic protein-disulfide oxidoreductase (179 aa), fasta scores; E(): 7e-05, 26.5% identity in 136 aa overlap and similar to SW:THIX_HAEIN (EMBL:U32791),HI1115, Haemophilus influenzae thioredoxin-like protein (167 aa), fasta scores; E(): 7.6e-26, 42.4% identity in 170 aa overlap. Contains a probable N-terminal signal sequence; periplasmic thioredoxin 589403..589912 Neisseria meningitidis Z2491 906607 YP_002342085.1 CDS NMA0613 NC_003116.1 590256 590696 D NMA0613, probable marR-family transcriptional regulator, len: 146 aa; shows weak similarity to TR:P94314 (EMBL:U64802), cinR, Butyrivibrio fibrisolvens transcriptional repressor of cinnamoyl ester hydrolase (142 aa), fasta scores; E(): 0.0013, 30.3% identity in 145 aa overlap and SW:HPCR_ECOLI (EMBL:S56952), hpaR,Escherichia coli homoprotocatechuate degradative operon repressor (148 aa), fasta scores; E(): 8.3e-26, 55.7% identity in 131 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family and PS01117 Bacterial regulatory proteins, marR family signature; marR-family transcriptional regulator 590256..590696 Neisseria meningitidis Z2491 906608 YP_002342086.1 CDS NMA0614 NC_003116.1 590811 591311 D NMA0614, probable NADH:FMN oxidoreductase, len: 166 aa; similar to many NADH:FMN redox coupling protein components from multi-component monooxygenases e.g. TR:Q57501 (EMBL:Z37980), hpaC, Escherichia coli 4-hydroxyphenylacetate 3-monooxygenase coupling protein (170 aa), fasta scores; E(): 5.7e-24, 43.8% identity in 153 aa overlap and TR:O87008 (EMBL:U83405), tftC,Burkholderia cepacia chlorophenol-4-monooxygenase component 1 (179 aa), fasta scores; E(): 3.1e-15, 35.0% identity in 163 aa overlap; NADH:FMN oxidoreductase 590811..591311 Neisseria meningitidis Z2491 906609 YP_002342087.1 CDS NMA0615 NC_003116.1 591329 592024 D NMA0615, sugar-phosphate nucleotidyl transferase, len: 231 aa; Similar to the N-terminal regions of many e.g. TR:O08245 (EMBL:Y10907), mtmD,Streptomyces argillaceus TDP-D-glucose synthase (355 aa),fasta scores; E(): 4.2e-11, 30.7% identity in 241 aa overlap and SW:RFBA_XANCA (EMBL:L2394), rfbA, Xanthomonas campestris glucose-1-phosphate thymidylyltransferase involved in lipopolysaccharide biosynthesis (295 aa),fasta scores; E(): 9.1e-10, 31.7% identity in 240 aa overlap. Of a similar length to TR:AAD22456 (EMBL:AF116284) Pseudomonas aeruginosa hypothetical protein located downstream of a virulence factor (224 aa), fasta scores; E(): 0, 54.0% identity in 226 aa overlap. Similar to NMA0205, fasta scores; E(): 7.2e-09,27.9% identity in 247 aa overlap and NMA0188, fasta scores; E(): 7.2e-09, 27.9% identity in 247 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase,Nucleotidyl transferase; sugar-phosphate nucleotidyl transferase 591329..592024 Neisseria meningitidis Z2491 906610 YP_002342088.1 CDS NMA0616 NC_003116.1 592270 592701 R NMA0616, probable integral membrane protein, len: 143 aa; similar to bacterial hypothetical proteins e.g. SW:YCB6_PSEDE (EMBL:M62866) Pseudomonas denitrificans hypothetical protein (141 aa), fasta scores; E(): 1.4e-30,55.4% identity in 139 aa overlap. Contains Pfam match to entry PF00892 DUF6, Integral membrane protein. Contains hydrophobic, probable membrane-spanning regions; integral membrane protein complement(592270..592701) Neisseria meningitidis Z2491 906611 YP_002342089.1 CDS fhs NC_003116.1 592876 594552 D catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 592876..594552 Neisseria meningitidis Z2491 906612 YP_002342090.1 CDS NMA0618 NC_003116.1 594667 595758 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 594667..595758 Neisseria meningitidis Z2491 906614 YP_002342091.1 CDS NMA0619 NC_003116.1 596020 597888 D NMA0619, lipopolysaccharide modification acyltransferase, len: 622 aa; similar to TR:P74874 (EMBL:U65941), oafA, Salmonella typhimurium integral membrane protein responsible for acetylation of the O-antigen (609 aa), fasta scores; E(): 0, 28.0% identity in 624 aa overlap and to TR:P72134 (EMBL:U50396), wbpC,Pseudomonas aeruginosa CDS involved in O-antigen (629 aa),fasta scores; E(): 0, 33.8% identity in 619 aa overlap. Also similar to several CDS from Caenorhabditis elegans e.g. TR:O02306 (EMBL:Z81147), T09E11.4, Caenorhabditis elegans hypothetical protein (650 aa), fasta scores; E(): 1.3e-24, 29.9% identity in 344 aa overlap. Contains hydrophobic, probable membrane-spanning regions; lipopolysaccharide modification acyltransferase 596020..597888 Neisseria meningitidis Z2491 906615 YP_002342092.1 CDS NMA0620 NC_003116.1 597950 599245 D NMA0620, tyrS, probable tyrosyl-tRNA synthetase,len: 431 aa; similar to many e.g. SW:SYY_ECOLI (EMBL:J01719), tyrS, Escherichia coli tyrosyl-tRNA synthetase (EC 6.1.1.1) (423 aa), fasta scores; E(): 0,63.1% identity in 431 aa overlap. Contains Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y) and PS00178 Aminoacyl-transfer RNA synthetases class-I signature; tyrosyl-tRNA synthetase 597950..599245 Neisseria meningitidis Z2491 906616 YP_002342093.1 CDS ribF NC_003116.1 599508 600464 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 599508..600464 Neisseria meningitidis Z2491 906617 YP_002342094.1 CDS ileS NC_003116.1 600606 603395 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 600606..603395 Neisseria meningitidis Z2491 906618 YP_002342095.1 CDS lspA NC_003116.1 604582 605079 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 604582..605079 Neisseria meningitidis Z2491 906619 YP_002342096.1 CDS ispH NC_003116.1 605108 606076 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 605108..606076 Neisseria meningitidis Z2491 906620 YP_002342097.1 CDS NMA0625 NC_003116.1 606164 606643 R NMA0625, phosphatase, len: 159 aa; shows weak similarity to phosphoglycolate phosphatases e.g. SW:GPHC_ALCEU (EMBL:M68904), cbbzC, Alcaligenes eutrophus chromosomal phosphoglycolate phosphatase (231 aa), fasta scores; E(): 6.5e-08, 30.2% identity in 172 aa overlap and SW:GPH_ECOLI (EMBL:Z19601), gph, Escherichia coli phosphoglycolate phosphatase (252 aa), fasta scores; E(): 4.2e-05, 23.1% identity in 173 aa overlap. The N-terminus may have been removed by insertion of the neighbouring IS element as this CDS appears to be shorter; phosphatase complement(606164..606643) Neisseria meningitidis Z2491 906621 YP_002342098.1 CDS NMA0629 NC_003116.1 609568 609894 R NMA0629, len: 108 aa; unknown; hypothetical protein complement(609568..609894) Neisseria meningitidis Z2491 906624 YP_002342099.1 CDS NMA0630 NC_003116.1 609887 610801 R NMA0630, len: 304 aa; unknown, shows weak similarity to TR:BAA80229 (EMBL:AP000061), APE1240,Aeropyrum pernix hypothetical protein (340 aa), fasta scores; E(): 0.00016, 27.1% identity in 266 aa overlap; hypothetical protein complement(609887..610801) Neisseria meningitidis Z2491 906625 YP_002342100.1 CDS NMA0631 NC_003116.1 610868 614116 R NMA0631, len: 1082 aa; unknown; hypothetical protein complement(610868..614116) Neisseria meningitidis Z2491 906626 YP_002342101.1 CDS NMA0632 NC_003116.1 614394 617828 R NMA0632, dnaE, probable DNA polymerase III, alpha subunit, len: 1144 aa; similar to many e.g. SW:DP3A_VIBCH (EMBL:U30472), dnaE, Vibrio cholerae DNA polymerase III,alpha subunit (EC 2.7.7.7) (1159 aa), fasta scores; E(): 0, 46.2% identity in 1170 aa overlap; DNA polymerase III subunit alpha complement(614394..617828) Neisseria meningitidis Z2491 906627 YP_002342102.1 CDS NMA0633 NC_003116.1 618360 618593 D NMA0633, len: 77 aa; unknown, similar to SW:YBCJ_ECOLI (EMBL:D10588), ybcJ, Escherichia coli hypothetical protein (70 aa), fasta scores; E(): 7.7e-07,47.8% identity in 67 aa overlap and to the N-terminal half of TR:Q48692 (EMBL:X89367) Lactococcus lactis hypothetical protein (120 aa), fasta scores; E(): 5.4e-05, 43.9% identity in 66 aa overlap; hypothetical protein 618360..618593 Neisseria meningitidis Z2491 906629 YP_002342103.1 CDS NMA0634 NC_003116.1 618565 618780 D NMA0634, len: 71 aa; unknown; hypothetical protein 618565..618780 Neisseria meningitidis Z2491 906630 YP_002342104.1 CDS NMA0635 NC_003116.1 619076 619912 D NMA0635, len: 278 aa; unknown, similar to hypothetical proteins e.g. SW:YCIV_HAEIN (EMBL:U32820),HI1400, Haemophilus influenzae hypothetical protein (274 aa), fasta scores; E(): 0, 45.8% identity in 275 aa overlap and TR:Q9ZQI9 (EMBL:AC006218), F17L24.11,Arabidopsis thaliana hypothetical protein (312 aa), fasta scores; E(): 4.5e-20, 33.0% identity in 227 aa overlap; hypothetical protein 619076..619912 Neisseria meningitidis Z2491 906631 YP_002342105.1 CDS avtA NC_003116.1 619964 621256 R transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase complement(619964..621256) Neisseria meningitidis Z2491 906632 YP_002342106.1 CDS NMA0637 NC_003116.1 621312 623222 R NMA0637, pglD, pilin glycosylation protein, len: 636 aa; highly similar to TR:AAC25981 (EMBL:AF014804) pglD from Neisseria meningitidis MC58 (636 aa), fasta scores; E(): 0, 96.7% identity in 636 aa overlap. Similar to many genes implicated in lipopolysaccharide biosynthesis e.g. TR:O05349 (EMBL:Y07788), rfbU, Vibrio cholerae mannosyl-transferase essential for O-antigen biosynthesis (621 aa), fasta scores; E(): 0, 47.7% identity in 616 aa overlap; pilin glycosylation protein complement(621312..623222) Neisseria meningitidis Z2491 906633 YP_002342107.1 CDS NMA0638 NC_003116.1 623270 624445 R NMA0638, pglC, pilin glycosylation protein, len: 404 aa; highly similar to TR:AAC25980 (EMBL:AF014804) pglC from Neisseria meningitidis MC58 (391 aa), fasta scores; E(): 0, 95.1% identity in 391 aa overlap. Contains Pfam match to entry PF01041 DegT_DnrJ_EryC1,DegT/DnrJ/EryC1/StrS family; pilin glycosylation protein complement(623270..624445) Neisseria meningitidis Z2491 906634 YP_002342108.1 CDS NMA0639 NC_003116.1 624523 625764 R NMA0639, pglB, pilin glycosylation protein, len: 413 aa; highly similar to TR:AAC25979 (EMBL:AF014804) pglB from Neisseria meningitidis MC58 (413 aa), fasta scores; E(): 0, 94.6% identity in 410 aa overlap. Possibly a transferase; N-terminal half is similar to the C-terminal half of e.g. SW:RFBP_SALTY (EMBL:X56793), rfbP, Salmonella typhimurium UDP-phosphate galactosephosphotransferase (476 aa), blastp scores; Expect = 1.5e-24. Contains an hydrophobic, membrane-spanning region near the N-terminus. Contains Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats); pilin glycosylation protein complement(624523..625764) Neisseria meningitidis Z2491 906635 YP_002342109.1 CDS NMA0640 NC_003116.1 625757 626920 R NMA0640, len: 387 aa; unknown, shows very weak similarity to galactosyl transferases e.g. SW:RFAB_SALTY (EMBL:AF026386), rfaB, Salmonella typhimurium lipopolysaccharide 1,6-galactosyltransferase (359 aa),fasta scores; E(): 0.053, 25.3% identity in 324 aa overlap; hypothetical protein complement(625757..626920) Neisseria meningitidis Z2491 906636 YP_002342110.1 CDS NMA0641 NC_003116.1 626940 628021 R NMA0641, glycosyl transferase, pseudogene,len: 1079 bp; shows weak similarity to the C-terminal half of many e.g. SW:CAPM_STAAU (EMBL:U10927), capM,Staphylococcus aureus type 1 capsular polysaccharide biosynthesis protein (380 aa), fasta scores; E(): 6.4e-09,26.8% identity in 190 aa overlap and TR:O84910 (EMBL:AF010183), wbpZ, Pseudomonas aeruginosa glycosyltransferase involved in A-band polysaccharide biosynthesis (381 aa), fasta scores; E(): 9e-07, 25.7% identity in 191 aa overlap. Also similar to NMA1057, fasta scores; E(): 1.3e-06, 28.7% identity in 129 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1,Glycosyl transferases group 1. Contains a g{16} repeat which would allow this to be translated as an intact CDS,if variable; hypothetical protein complement(join(626940..627518,627521..628021)) Neisseria meningitidis Z2491 906637 YP_002342111.1 CDS NMA0643 NC_003116.1 628018 629439 R NMA0643, lipopolysaccharide biosynthesis translocase, len: 473 aa; shows weak similarity to several proteins implicated in lipopolysaccharide biosynthesis e.g. TR:Q56050 (EMBL:U40830), epsM, Streptococcus thermophilus eps cluster gene (473 aa), fasta scores; E(): 3.8e-10, 20.4% identity in 471 aa overlap and TR:Q56865 (EMBL:U46859), wzx, Yersinia enterocolitica O-antigen 'flippase' (429 aa), fasta scores; E(): 3.2e-05,21.7% identity in 392 aa overlap. Contains hydrophobic,probable membrane-spanning regions; lipopolysaccharide biosynthesis translocase complement(628018..629439) Neisseria meningitidis Z2491 906638 YP_002342112.1 CDS NMA0644 NC_003116.1 629634 630743 R NMA0644, ribD, probable diaminohydroxyphosphoribosylaminopyrimidine deaminase/phosphoribosylamino)uracil reductase, len: 369 aa; similar to many e.g. SW:RIBD_ACTPL (EMBL:U27202),ribD, Actinobacillus pleuropneumoniae diaminohydroxyphosphoribosylaminopyrimidine deaminase/phosphoribosylamino)uracil reductase (EC 3.5.4.26) (EC 1.1.1.193) (410 aa), fasta scores; E(): 0,42.4% identity in 323 aa overlap. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature and PS00017 ATP/GTP-binding site motif A (P-loop); diaminohydroxyphosphoribosylaminopyrimidine deaminase/phosphoribosylamino)uracil reductase complement(629634..630743) Neisseria meningitidis Z2491 906639 YP_002342113.1 CDS nrdR NC_003116.1 630775 631239 R NMA0645, len: 154 aa; unknown, similar to many bacterial hypothetical proteins e.g. TR:O50470 (EMBL:AJ002783) Neisseria gonorrhoeae hypothetical protein (partial CDS) (109 aa), fasta scores; E(): 0, 93.5% identity in 108 aa overlap; transcriptional regulator NrdR complement(630775..631239) Neisseria meningitidis Z2491 906640 YP_002342114.1 CDS NMA0646 NC_003116.1 631269 632111 R NMA0646, len: 280 aa; unknown, highly similar to TR:O50469 (EMBL:AJ002783), yafJ, Neisseria gonorrhoeae hypothetical protein (280 aa), fasta scores; E(): 0, 93.6% identity in 281 aa overlap and similar to SW:YAFJ_ECOLI (EMBL:D38582), yafJ, Escherichia coli hypothetical protein (255 aa), fasta scores; E(): 0, 51.8% identity in 255 aa overlap and to other bacterial hypothetical proteins; hypothetical protein complement(631269..632111) Neisseria meningitidis Z2491 906641 YP_002342115.1 CDS aroB NC_003116.1 632755 633834 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(632755..633834) Neisseria meningitidis Z2491 906642 YP_002342116.1 CDS aroK NC_003116.1 633914 634426 R catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase complement(633914..634426) Neisseria meningitidis Z2491 906643 YP_002342117.1 CDS NMA0650 NC_003116.1 635588 637873 R NMA0650, pilQ, pilus secretin, len: 761 aa; highly similar to secretins from Neisseria spp. e.g. TR:Q9ZHF3 (EMBL:AF066056), pilQ, Neisseria meningitidis strain H44/76 (serogroup B) secretin precursor (766 aa), fasta scores; E(): 0, 84.9% identity in 766 aa overlap. Contains 5 copies of the small basic repeat PAKQQAAA (with slight degeneracy). Contains Pfam match to entry PF00263 Bac_GSPproteins, Bacterial type II secretion system protein and PS00875 Bacterial type II secretion system protein D signature. Contains a probable N-terminal signal sequence; pilus secretin complement(635588..637873) Neisseria meningitidis Z2491 906644 YP_002342118.1 CDS NMA0651 NC_003116.1 637892 638437 R NMA0651, pilP, pilus assembly protein, len: 181 aa; highly similar to TR:Q50971 (EMBL:U40596), pilP, Neisseria gonorrhoeae type IV pilus biogenesis protein (180 aa),fasta scores; E(): 0, 96.7% identity in 181 aa overlap. Contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; pilus assembly protein complement(637892..638437) Neisseria meningitidis Z2491 906645 YP_002342119.1 CDS NMA0652 NC_003116.1 638455 639102 R NMA0652, pilO, pilus assembly protein, len: 215 aa; highly similar to TR:Q50970 (EMBL:U40596), pilO, Neisseria gonorrhoeae type IV pilus biogenesis protein (215 aa),fasta scores; E(): 0, 98.6% identity in 215 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains an hydrophobic, membrane-spanning region; pilus assembly protein complement(638455..639102) Neisseria meningitidis Z2491 906646 YP_002342120.1 CDS NMA0653 NC_003116.1 639103 639702 R NMA0653, pilN, probable pilus assembly protein,len: 199 aa; similar to TR:Q52540 (EMBL:L28837), pilN,Pseudomonas syringae gene required for pilus expression (199 aa), fasta scores; E(): 1.5e-13, 27.9% identity in 197 aa overlap and highly similar to TR:O05129 (EMBL:U72876), pilN, Neisseria gonorrhoeae FA19 pilN (203 aa), fasta scores; E(): 0, 81.0% identity in 179 aa overlap (divergent at the C-terminus). Contains an hydrophobic, membrane-spanning region; pilus assembly protein complement(639103..639702) Neisseria meningitidis Z2491 906647 YP_002342121.1 CDS NMA0654 NC_003116.1 639705 640820 R NMA0654, pilM, probable pilus assembly protein,len: 371 aa; similar to TR:Q51351 (EMBL:U12892), pilM,Pseudomonas aeruginosa type 4 fimbrial assembly protein (354 aa), fasta scores; E(): 1.5e-17, 25.6% identity in 347 aa overlap and highly similar to TR:O05130 (EMBL:U72876), pilM, Neisseria gonorrhoeae FA19 pilM (371 aa), fasta scores; E(): 0, 94.6% identity in 371 aa overlap; pilus assembly protein complement(639705..640820) Neisseria meningitidis Z2491 906648 YP_002342122.1 CDS NMA0655 NC_003116.1 640972 643368 D NMA0655, ponA, penicillin-binding protein 1, len: 798 aa; previously sequenced as TR:O05194 (EMBL:U80933) Neisseria meningitidis Z2491 penicillin-binding protein 1 (798 aa), fasta scores; E(): 0, 100.0% identity in 798 aa overlap. Contains Pfam matches to entry PF00912 Transglycosyl, Transglycosylase and to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain. Contains probable N-terminal signal sequence; penicillin-binding protein 1 640972..643368 Neisseria meningitidis Z2491 906649 YP_002342123.1 CDS engB NC_003116.1 643489 644118 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(643489..644118) Neisseria meningitidis Z2491 906650 YP_002342124.1 CDS NMA0658 NC_003116.1 644324 644947 D NMA0658, cyc, probable cytochrome C, len: 207 aa; similar to many e.g. SW:CYC4_PSEST (EMBL:U05988), cc4,Pseudomonas stutzeri cytochrome C4 precursor (210 aa),fasta scores; E(): 1e-19, 34.9% identity in 212 aa overlap. Contains two Pfam matches to entry PF00034 cytochrome_c, Cytochrome c and two PS00190 Cytochrome c family heme-binding site signature. Contains a probable N-terminal signal sequence; cytochrome C 644324..644947 Neisseria meningitidis Z2491 906651 YP_002342125.1 CDS NMA0659 NC_003116.1 645224 647176 D NMA0659, membrane protein, len: 650 aa; similar to TR:Q9ZG10 (EMBL:AF089765), resB, Thiobacillus ferrooxidans cytochrome C biosynthesis protein (591 aa), fasta scores; E(): 0, 32.0% identity in 659 aa overlap. Shows weak similarity to TR:O50041 (EMBL:U71000),ccs1, Chlamydomonas reinhardtii nuclear gene required for the post-translational assembly of chloroplast cytochrome C (613 aa), fasta scores; E(): 4.2e-05, 26.2% identity in 305 aa overlap. Contains a N-terminal signal sequence and hydrophobic, membrane-spanning regions; hypothetical protein 645224..647176 Neisseria meningitidis Z2491 906652 YP_002342126.1 CDS NMA0660 NC_003116.1 647169 648356 D NMA0660, probable membrane protein, len: 395 aa; similar to chloroplast genes required for cytochrome C biosynthesis e.g SW:CCSA_CHLRE (EMBL:U15556), ccsA,Chlamydomonas reinhardtii cytochrome C biogenesis protein (353 aa), fasta scores; E(): 1e-30, 36.1% identity in 266 aa overlap. Also similar to bacterial hypothetical proteins e.g. TR:Q9ZG09 (EMBL:AF089766), resC,Thiobacillus ferrooxidans cytochrome C-type biogenesis protein (381 aa), fasta scores; E(): 0, 45.2% identity in 378 aa overlap. Contains hydrophobic, probable membrane-spanning regions; hypothetical protein 647169..648356 Neisseria meningitidis Z2491 906653 YP_002342127.1 CDS gcp NC_003116.1 648473 649537 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 648473..649537 Neisseria meningitidis Z2491 906654 YP_002342128.1 CDS NMA0662 NC_003116.1 649581 650477 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(649581..650477) Neisseria meningitidis Z2491 906655 YP_002342129.1 CDS metK NC_003116.1 650823 651992 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 650823..651992 Neisseria meningitidis Z2491 906656 YP_002342130.1 CDS NMA0664 NC_003116.1 652241 652883 D transposase for IS1016 join(652241..652693,652692..652883) Neisseria meningitidis Z2491 906657 YP_002342131.1 CDS NMA0665 NC_003116.1 652959 654368 R NMA0665, probable peptidase, len: 469 aa; similar to many e.g. TR:O85665 (EMBL:AF071224), pbp3, Neisseria gonorrhoeae penicillin binding protein 3 (469 aa), fasta scores; E(): 0, 96.6% identity in 469 aa overlap and SW:PBP4_ECOLI (EMBL:X59460), dacB, Escherichia coli penicillin-binding protein (477 aa), fasta scores; E(): 7.9e-21, 27.0% identity in 456 aa overlap. Contains probable N-terminal signal sequence; peptidase complement(652959..654368) Neisseria meningitidis Z2491 906659 YP_002342132.1 CDS NMA0666 NC_003116.1 654533 655099 D NMA0666, probable oxidoreductase, len: 188 aa; similar to TR:AAD37373 (EMBL:AF145234), nqr, Arabidopsis thaliana NADPH:quinone oxidoreductase 9196 aa), fasta scores; E(): 2.9e-13, 35.7% identity in 168 aa overlap and to bacterial hypothetical proteins; oxidoreductase 654533..655099 Neisseria meningitidis Z2491 906660 YP_002342133.1 CDS NMA0668 NC_003116.1 655668 656981 D NMA0668, probable transmembrane transport protein,len: 437 aa; similar to e.g. SW:CITM_BACSU (EMBL:U62003),citM, Bacillus subtilis Mg2+/citrate complex secondary transporter (433 aa), fasta scores; E(): 0, 33.2% identity in 437 aa overlap. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein 655668..656981 Neisseria meningitidis Z2491 906661 YP_002342134.1 CDS NMA0670 NC_003116.1 657370 658620 D NMA0670, two-component system sensor kinase, len: 416 aa; similar to several sensor kinases e.g. SW:IRLS_BURPS (EMBL:AF005358), irlS, Burkholderia pseudomallei sensor protein (464 aa), fasta scores; E(): 4.7e-16, 26.8% identity in 381 aa overlap. Also similar to SW:YGIY_ECOLI (EMBL:U28377), ygiY, Escherichia coli probable sensor protein (449 aa), fasta scores; E(): 8.7e-28, 31.6% identity in 335 aa overlap. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain. Contains an hydrophobic, membrane-spanning region; two-component system sensor kinase 657370..658620 Neisseria meningitidis Z2491 906663 YP_002342135.1 CDS NMA0672 NC_003116.1 658879 660372 R NMA0672, len: 497 aa; unknown, similar to the N-terminal half of SW:RNE_ECOLI (EMBL:AE000209), rne,Escherichia coli ribonuclease E (1061 aa), fasta scores; E(): 0, 35.6% identity in 464 aa overlap and to SW:CAFA_ECOLI (EMBL:X57166), cafA, Escherichia coli cytoplasmic axial filament protein (488 aa), fasta scores; E(): 0, 49.5% identity in 491 aa overlap. Also similar to many bacterial hypothetical proteins. Similar to the N-terminal half of NMA0071 (rne), fasta scores; E(): 0,33.0% identity in 482 aa overlap; hypothetical protein complement(658879..660372) Neisseria meningitidis Z2491 906665 YP_002342136.1 CDS NMA0673 NC_003116.1 660586 660843 D NMA0673, glutaredoxin, len: 85 aa; similar to many e.g. SW:GLR3_ECOLI (EMBL:U00039), grxC,Escherichia coli glutaredoxin 3 (82 aa), fasta scores; E(): 5.4e-11, 47.5% identity in 80 aa overlap. Contains PS00194 Thioredoxin family active site; glutaredoxin 660586..660843 Neisseria meningitidis Z2491 906666 YP_002342137.1 CDS secB NC_003116.1 660864 661307 D molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 660864..661307 Neisseria meningitidis Z2491 906667 YP_002342138.1 CDS NMA0675 NC_003116.1 661393 663435 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 661393..663435 Neisseria meningitidis Z2491 906668 YP_002342139.1 CDS argC NC_003116.1 664694 665737 R catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase complement(664694..665737) Neisseria meningitidis Z2491 906669 YP_002342140.1 CDS NMA0677 NC_003116.1 665734 666027 R NMA0677, len: 97 aa; unknown, contains a region similar to NMA0700, fasta scores; E(): 6.1e-09, 64.4% identity in 45 aa overlap; hypothetical protein complement(665734..666027) Neisseria meningitidis Z2491 906670 YP_002342141.1 CDS NMA0680 NC_003116.1 667552 667779 D NMA0680, lipoprotein, len: 75 aa; unknown,contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains one hydrophobic, membrane-spanning region. Lies within a region of unusually low GC content; lipoprotein 667552..667779 Neisseria meningitidis Z2491 906673 YP_002342142.1 CDS NMA0681 NC_003116.1 667772 668125 D NMA0681, len: 117 aa; unknown; hypothetical protein 667772..668125 Neisseria meningitidis Z2491 906674 YP_002342143.1 CDS NMA0684 NC_003116.1 670145 670447 D NMA0684, len: 100 aa; unknown; hypothetical protein 670145..670447 Neisseria meningitidis Z2491 906676 YP_002342144.1 CDS NMA0685 NC_003116.1 670462 670632 D NMA0685, len: 56 aa; unknown; hypothetical protein 670462..670632 Neisseria meningitidis Z2491 906677 YP_002342145.1 CDS NMA0687 NC_003116.1 671031 672773 D NMA0687, probable periplasmic protein, len: 580 aa; similar to hemolysin activating proteins e.g. SW:HLYB_SERMA (EMBL:M22618), shlB, Serratia marcescens protein required for extracellular secretion and activation of hemoysin (557 aa), fasta scores; E(): 1.7e-07, 25.1% identity in 542 aa overlap and to SW:FHAC_BORPE (EMBL:X64876), fhaC, Bordetella pertussis hemolysin activator-like protein (584 aa), fasta scores; E(): 9.7e-08, 25.8% identity in 577 aa overlap. Contains a region identical to TR:P72090 (EMBL:U56747) Neisseria meningitidis strain Z2491 sequence found in Z2491 but not in Neisseria gonorrhoeae strain MS11, fasta scores; E(): 2.4e-23, 100.0% identity in 69 aa overlap. Contains a probable N-terminal signal sequence; hypothetical protein 671031..672773 Neisseria meningitidis Z2491 906679 YP_002342146.1 CDS NMA0688 NC_003116.1 672883 678930 D NMA0688, len: 2015 aa; similar to the N-terminal half of SW:FHAB_BORPE (EMBL:M60351), fhaB, Bordetella pertussis filamentous haemagglutinin (3591 aa), fasta scores; E(): 8.4e-25, 22.8% identity in 1884 aa overlap and to SW:HLYA_PROMI (EMBL:M30186), hmpA, Proteus mirabilis calcium-independent hemolysin (1577 aa), fasta scores; E(): 1.9e-09, 22.9% identity in 1692 aa overlap. Contains a region identical to TR:P72087 (EMBL:U56741) Neisseria meningitidis strain Z2491 sequence found in Z2491 but not in Neisseria gonorrhoeae strain MS11, fasta scores; E(): 2.3e-32, 100.0% identity in 117 aa overlap. The C-terminal region is highly similar to NMA0690, fasta scores; E(): 0, 70.6% identity in 571 aa overlap and NMA0962, fasta scores; E(): 0, 54.0% identity in 622 aa overlap. Also contains a sequence motif ILAYSKLVAGTVSGVVGGDVNTAANAAKVAIENNLL (codon 1629 to codon 1664) which occurs (with some degeneracy) within NMA0690,NMA0692 and NMA0695; hemagglutinin 672883..678930 Neisseria meningitidis Z2491 906680 YP_002342147.1 CDS NMA0689 NC_003116.1 678935 679318 D NMA0689, len: 127 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 678935..679318 Neisseria meningitidis Z2491 906681 YP_002342148.1 CDS NMA0690 NC_003116.1 679568 682249 D NMA0690, len: 893 aa; unknown, highly similar to the C-terminal region of NMA0688, fasta scores; E(): 0,70.6% identity in 571 aa overlap and to NMA0992, fasta scores; E(): 0, 71.9% identity in 620 aa overlap. Also contains a sequence motif ILAYSKLVAGTVSGVVGGDVNAAANAAEVAVKNNQL (codon 540 to codon 575) which occurs (with some degeneracy) within NMA0688,NMA0692, and NMA0695. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 679568..682249 Neisseria meningitidis Z2491 906682 YP_002342149.1 CDS NMA0691 NC_003116.1 682265 682696 D NMA0691, len: 143 aa; unknown, Asn-rich N-terminus,lies within a region of unusually low GC content; hypothetical protein 682265..682696 Neisseria meningitidis Z2491 906684 YP_002342150.1 CDS NMA0692 NC_003116.1 682841 685342 D NMA0692, len: 692 aa; unknown, contains an Ala-rich region from aa 330-400 approx. Highly similar to NMA0690,fasta scores; E(): 0, 71.9% identity in 620 aa overlap and to the C-terminal region of NMA0688, fasta scores; E(): 0,54.0% identity in 622 aa overlap. The Ala-rich region is not well conserved in NMA0690 and NMA0688. Also contains a sequence motif IAYSQIIAGSAVALVKGDVNTAVNAATVAVENNSL (codon 586 to codon 620) which occurs (with some degeneracy) within NMA0688, NMA0690, and NMA0695. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 682841..685342 Neisseria meningitidis Z2491 906685 YP_002342151.1 CDS NMA0693 NC_003116.1 685339 685827 D NMA0693, len: 162 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 685339..685827 Neisseria meningitidis Z2491 906686 YP_002342152.1 CDS NMA0694 NC_003116.1 686015 686287 D NMA0694, len: 90 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 686015..686287 Neisseria meningitidis Z2491 906687 YP_002342153.1 CDS NMA0695 NC_003116.1 686491 687459 D NMA0695, len: 322 aa; unknown, contains an sequence motif ITAYSKLVAGTASAVVGGDVNTAANAAQIAVENNTL (codon 22 to codon 57) which occurs (with some degeneracy) at different positions within NMA0688, NMA0690 and NMA0692; hypothetical protein 686491..687459 Neisseria meningitidis Z2491 906688 YP_002342154.1 CDS NMA0696 NC_003116.1 687462 688397 D NMA0696, len: 311 aa; unknown; hypothetical protein 687462..688397 Neisseria meningitidis Z2491 906689 YP_002342155.1 CDS NMA0696A NC_003116.1 688810 689160 D NMA0696A, len: 311 aa; unknown; hypothetical protein 688810..689160 Neisseria meningitidis Z2491 906690 YP_002342156.1 CDS NMA0697 NC_003116.1 689167 689346 D NMA0697, len: 59 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 689167..689346 Neisseria meningitidis Z2491 906691 YP_002342157.1 CDS NMA0698 NC_003116.1 689728 690186 D NMA0698, periplasmic protein, len: 152 aa; unknown, contains a probable N-terminal signal sequence and lies within a region of unusually low GC content; hypothetical protein 689728..690186 Neisseria meningitidis Z2491 906692 YP_002342158.1 CDS rbn NC_003116.1 690700 691926 R RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; this protein contains a C-terminal extension of unknown function; ribonuclease BN/unknown domain fusion protein complement(690700..691926) Neisseria meningitidis Z2491 906694 YP_002342159.1 CDS NMA0702 NC_003116.1 692470 693129 D NMA0702, len: 219 aa; similar to TR:Q52925 (EMBL:Z50189), exsB, Rhizobium meliloti regulator of succinoglycan biosynthesis (not a transcriptional regulator) (234 aa), fasta scores; E(): 3.1e-15, 32.7% identity in 205 aa overlap. Also similar to many hbacterial ypothetical proteins e.g. SW:YBAX_HAEIN (EMBL:U32798), HI1191, Haemophilus influenzae hypothetical protein (196 aa), fasta scores; E(): 0, 79.2% identity in 173 aa overlap; hypothetical protein 692470..693129 Neisseria meningitidis Z2491 906696 YP_002342160.1 CDS NMA0703 NC_003116.1 693157 693675 D NMA0703, len: 172 aa; unknown; hypothetical protein 693157..693675 Neisseria meningitidis Z2491 906697 YP_002342161.1 CDS NMA0704 NC_003116.1 693682 694104 D NMA0704, len: 140 aa; similar to many hypothetical proteins e.g. SW:YB90_HAEIN (EMBL:U32798), HI1190,Haemophilus influenzae hypothetical protein (141 aa),fasta scores; E(): 5.1e-32, 58.0% identity in 138 aa overlap. Shows very weak similarity to eukaryotic 6-pyruvoyl-tetrahydropterin synthases e.g. SW:PTPS_RAT (EMBL:M77850), pts, Rattus norvegicus 6-pyruvoyl tetrahydrobiopterin synthase precursor (EC 4.6.1.10) (144 aa), fasta scores; E(): 0.0062, 27.3% identity in 154 aa overlap. Contains Pfam match to entry PF01242 PTPS,6-pyruvoyl tetrahydropterin synthase; hypothetical protein 693682..694104 Neisseria meningitidis Z2491 906698 YP_002342162.1 CDS NMA0706 NC_003116.1 694373 694744 D NMA0706, membrane protein, len: 123 aa; similar to SW:YTRP_LACLA (EMBL:M87483) Lactococcus lactis (subsp. lactis) hypothetical protein (119 aa), fasta scores; E(): 9.2e-11, 39.7% identity in 116 aa overlap. Contains hydrophobic, membrane-spanning regions; hypothetical protein 694373..694744 Neisseria meningitidis Z2491 906699 YP_002342163.1 CDS NMA0707 NC_003116.1 694741 695379 D NMA0707, len: 212 aa; similar to many bacterial hypothetical proteins e.g. SW:YGCF_HAEIN (EMBL:U32798),HI1189, Haemophilus influenzae hypothetical protein (211 aa), fasta scores; E(): 0, 61.4% identity in 202 aa overlap; hypothetical protein 694741..695379 Neisseria meningitidis Z2491 906700 YP_002342164.1 CDS NMA0708 NC_003116.1 696057 697142 R hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase complement(696057..697142) Neisseria meningitidis Z2491 906701 YP_002342165.1 CDS NMA0709 NC_003116.1 697199 698719 R NMA0709, probable integral membrane protein, len: 506 aa; similar to bacterial hypothetical proteins e.g. SW:YF86_HAEIN (EMBL:U32832), HI1586, Haemophilus influenzae hypothetical protein (519 aa), fasta scores; E(): 0, 60.7% identity in 507 aa overlap. Contains hydrophobic, probable membrane-spanning regions; integral membrane protein complement(697199..698719) Neisseria meningitidis Z2491 906702 YP_002342166.1 CDS NMA0710 NC_003116.1 698921 700420 R NMA0710, probable periplasmic serine protease, len: 499 aa; similar to many e.g. TR:Q57155 (EMBL:U49151),mucD, Pseudomonas aeruginosa gene from locus affecting conversion to mucoidy in cystic fibrosis (474 aa), fasta scores; E(): 0, 49.8% identity in 454 aa overlap and SW:HTRA_ECOLI (EMBL:M36536), htrA, Escherichia coli protease DO precursor (EC 3.4.21.-) (474 aa), fasta scores; E(): 0, 33.5% identity in 457 aa overlap. Contains two Pfam matches to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF), Pfam match to entry PF00089 trypsin, Trypsin and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; serine protease complement(698921..700420) Neisseria meningitidis Z2491 906703 YP_002342167.1 CDS NMA0711 NC_003116.1 700558 701187 R NMA0711, nth, probable endonuclease III, len: 209 aa; similar to many e.g. SW:END3_ECOLI (EMBL:J02857), nth,Escherichia coli endonuclease III (EC 4.2.99.18) (211 aa),fasta scores; E(): 0, 72.1% identity in 208 aa overlap. Contains Pfam match to entry PF00730 Endonuclease_3,Endonuclease III and PS01155 Endonuclease III family signature; endonuclease III complement(700558..701187) Neisseria meningitidis Z2491 906704 YP_002342168.1 CDS NMA0712 NC_003116.1 701233 701646 R NMA0712, membrane protein, len: 137 aa; similar to e.g. SW:YQAA_ECOLI (EMBL:AE000353), yqaA,Escherichia coli hypothetical protein (142 aa), fasta scores; E(): 1.1e-12, 34.8% identity in 141 aa overlap. Contains hydrophobic, membrane-spanning regions; hypothetical protein complement(701233..701646) Neisseria meningitidis Z2491 906705 YP_002342169.1 CDS NMA0714 NC_003116.1 702236 703459 D NMA0714, probable transmembrane hexose transporter,len: 407 aa; similar to sugar transporters e.g. SW:GLUP_BRUAB (EMBL:U43785), gluP, Brucella abortus glucose/galactose transporter (412 aa), fasta scores; E(): 0, 52.9% identity in 403 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains hydrophobic, probable membrane-spanning regions; transmembrane hexose transporter 702236..703459 Neisseria meningitidis Z2491 906706 YP_002342170.1 CDS NMA0715 NC_003116.1 703750 705129 D NMA0715, probable transmembrane transport protein,len: 459 aa; similar to SW:NHAC_BACFI (EMBL:U61539), nhaC,Bacillus firmus Na(+)/H(+) antiporter (462 aa), fasta scores; E(): 0, 36.5% identity in 446 aa overlap and to transporters. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein 703750..705129 Neisseria meningitidis Z2491 906707 YP_002342171.1 CDS NMA0716 NC_003116.1 705258 706082 R NMA0716, len: 274 aa; shows weak similarity to SW:HLYC_TREHY (EMBL:X73141), tlyC, Treponema hyodysenteriae hemolysin C (268 aa), fasta scores; E(): 7.4e-23, 33.7% identity in 252 aa overlap. Also similar to many hypothetical proteins e.g. SW:YBEX_ECOLI (EMBL:AE000170), ybeX, Escherichia coli hypothetical protein (292 aa), fasta scores; E(): 0, 51.1% identity in 266 aa overlap. Shows weak similarity to the C-terminal half of NMA1694, E(): 9.5e-17, 26.4% identity in 242 aa overlap. The membrane-spanning regions of NMA1694 do not lie within this region. Contains two Pfam matches to entry PF00571 CBS, CBS domain; hypothetical protein complement(705258..706082) Neisseria meningitidis Z2491 906708 YP_002342172.1 CDS NMA0717 NC_003116.1 706084 706599 R NMA0717, len: 171 aa; similar to many bacterial hypothetical proteins e.g. SW:YBEY_ECOLI (EMBL:AE000170),ybeY, Escherichia coli hypothetical protein (155 aa),fasta scores; E(): 1.9e-24, 47.5% identity in 139 aa overlap; hypothetical protein complement(706084..706599) Neisseria meningitidis Z2491 906709 YP_002342173.1 CDS hemC NC_003116.1 706718 707653 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 706718..707653 Neisseria meningitidis Z2491 906710 YP_002342174.1 CDS aspC NC_003116.1 708160 709353 R catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(708160..709353) Neisseria meningitidis Z2491 906711 YP_002342175.1 CDS NMA0720 NC_003116.1 709435 709932 R NMA0720, len: 165 aa; unknown; hypothetical protein complement(709435..709932) Neisseria meningitidis Z2491 906712 YP_002342176.1 CDS NMA0721 NC_003116.1 710048 710251 D NMA0721, len: 67 aa; unknown; hypothetical protein 710048..710251 Neisseria meningitidis Z2491 906713 YP_002342177.1 CDS NMA0722 NC_003116.1 710419 712005 R NMA0722, probable transmembrane transport protein,len: 528 aa; shows weak similarity to lactate permeases e.g. SW:LLDP_ECOLI (EMBL:L13970), lldP, Escherichia coli L-lactate permease (551 aa), fasta scores; E(): 2.4e-29,25.3% identity in 550 aa overlap. Also similar to many hypothetical lactate permeases e.g. SW:YC18_HAEIN (EMBL:U32801), HI1218, Haemophilus influenzae L-lactate permease (532 aa), fasta scores; E(): 0, 57.3% identity in 527 aa overlap. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein complement(710419..712005) Neisseria meningitidis Z2491 906714 YP_002342178.1 CDS NMA0723 NC_003116.1 712274 712996 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(712274..712996) Neisseria meningitidis Z2491 906715 YP_002342179.1 CDS NMA0724 NC_003116.1 713245 716730 D NMA0724, len: 1161 aa; unknown, contains two coiled-coil domains and shows weak similarity to many bacterial hypothetical proteins (also with coiled-coil domains) e.g. TR:O59462 (EMBL:AP000007), PH1798,Pyrococcus horikoshii hypothetical protein (1179 aa),fasta scores; E(): 0, 23.7% identity in 1217 aa overlap. Also shows weak similarity to coiled-coil-containing eukaryotic proteins involved in chromosome maintenance e.g. SW:XCPE_XENLA (EMBL:U13674), xcap-E, Xenopus laevis chromosome assembly protein (1203 aa), fasta scores; E(): 4.9e-16, 22.1% identity in 1198 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 713245..716730 Neisseria meningitidis Z2491 906716 YP_002342180.1 CDS adhA NC_003116.1 717081 718121 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(717081..718121) Neisseria meningitidis Z2491 906717 YP_002342181.1 CDS NMA0726 NC_003116.1 718410 718799 R NMA0726, probable pilin, len: 129 aa; similar to many type IV pilins e.g. TR:Q60148 (EMBL:L76605), pilE,Pseudomonas aeruginosa fimbrial protein precursor (141 aa), fasta scores; E(): 1.8e-09, 37.5% identity in 128 aa overlap and TR:AAD27895 (EMBL:AF027189), comF,Acinetobacter sp. BD413 pilin-like competence factor involved in natural transformation (141 aa), fasta scores; E(): 3.9e-07, 34.9% identity in 126 aa overlap. Similar to NMA0424, fasta scores; E(): 2e-11, 32.8% identity in 131 aa overlap, NMA1110, fasta scores; E(): 4.1e-07, 31.9% identity in 141 aa overlap and NMA0264, fasta scores; E(): 4.3e-07, 41.2% identity in 68 aa overlap. Contains PS00409 Prokaryotic N-terminal methylation site and a probable N-terminal signal sequence; pilin complement(718410..718799) Neisseria meningitidis Z2491 906718 YP_002342182.1 CDS NMA0728 NC_003116.1 719025 720203 D NMA0728, probable periplasmic protein, len: 392 aa; shows weak similarity to proteins encoding membrane transport functions e.g. SW:ACRA_ECOLI (EMBL:M94248),acrA, Escherichia coli acriflavin resistance protein (397 aa), fasta scores; E(): 1.3e-08, 26.9% identity in 338 aa overlap and SW:MTRC_NEIGO (EMBL:U14993), mtrC, Neisseria gonorrhoeae membrane fusion protein (412 aa), fasta scores; E(): 3.7e-07, 26.3% identity in 396 aa overlap. Contains probable N-terminal signal sequence; hypothetical protein 719025..720203 Neisseria meningitidis Z2491 906719 YP_002342183.1 CDS NMA0729 NC_003116.1 720269 722203 D NMA0729, probable ABC transporter ATP-binding protein, len: 644 aa; similar to many e.g. SW:YBJZ_ECOLI (EMBL:AE000189), ybjZ, Escherichia coli hypothetical ABC transporter ATP-binding protein (648 aa), fasta scores; E(): 0, 52.2% identity in 648 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Contains hydrophobic, probable membrane-spanning regions; ABC transporter ATP-binding protein 720269..722203 Neisseria meningitidis Z2491 906720 YP_002342184.1 CDS NMA0730 NC_003116.1 722619 723401 R NMA0730, thiol:disulphide interchange protein, len: 260 aa; shows weak similarity to thiol:disulphide interchange proteins e.g. SW:DSBC_ECOLI (EMBL:M54884), dsbC, Escherichia coli thiol:disulfide interchange protein (236 aa), fasta scores; E(): 1.6e-13,27.7% identity in 231 aa overlap and SW:DSBC_ERWCH (EMBL:X76687), dsbC, Erwinia chrysanthemi thiol:disulfide interchange protein (238 aa), fasta scores; E(): 4.1e-11,24.5% identity in 220 aa overlap. Contains a probable N-terminal signal sequence. Cys 148 and Cys 151 are conserved in known thiol:disulphide interchange proteins; thiol:disulfide interchange protein complement(722619..723401) Neisseria meningitidis Z2491 906721 YP_002342185.1 CDS priA NC_003116.1 723540 725729 D binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 723540..725729 Neisseria meningitidis Z2491 906722 YP_002342186.1 CDS NMA0732 NC_003116.1 725776 726849 R NMA0732, probable integral membrane protein, len: 357 aa; unknown, contains hydrophobic, probable membrane-spanning regions; integral membrane protein complement(725776..726849) Neisseria meningitidis Z2491 906723 YP_002342187.1 CDS NMA0733 NC_003116.1 726897 727772 R NMA0733, probable transposase, len: 291 aa; similar to many e.g. similar to many e.g. TR:Q51474 (EMBL:M24471) Alteromonas atlantica CDS within insertion element IS492 which is involved in reversible inactivation of extracellular polysaccharide production (318 aa), fasta scores; E(): 1.6e-26, 34.8% identity in 267 aa overlap. Also shows weak similarity to pilin-inverting genes e.g. SW:PIV_MORLA (EMBL:M34367), piv, Moraxella acunata pilin gene inverting protein (322 aa), fasta scores; E(): 3.3e-11, 30.7% identity in 264 aa overlap. Highly similar to others from Neisseria meningitidis e.g. NMA1185, E(): 0, 94.3% identity in 279 aa overlap, also NMA2085. Contains Pfam match to entry PF01548 Transposase_9,Transposase; transposase complement(726897..727772) Neisseria meningitidis Z2491 906724 YP_002342188.1 CDS NMA0734 NC_003116.1 727827 728777 R NMA0734, probable transposase for IS1106A3, len: 316 aa; similar to many e.g. TR:CAB44967 (EMBL:AJ242841),Neisseria meningitidis transposase for insertion sequence IS1106A3 (335 aa), fasta scores; E(): 0, 97.2% identity in 282 aa overlap; transposase for IS1106A3 complement(727827..728777) Neisseria meningitidis Z2491 906725 YP_002342189.1 CDS dnaK NC_003116.1 729844 731772 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(729844..731772) Neisseria meningitidis Z2491 906727 YP_002342190.1 CDS NMA0737 NC_003116.1 731980 732252 R NMA0737, len: 90 aa; unknown; hypothetical protein complement(731980..732252) Neisseria meningitidis Z2491 906728 YP_002342191.1 CDS NMA0738 NC_003116.1 732438 733124 D NMA0738, transcriptional regulator, len: 228 aa; shows weak similarity to phage repressors e.g. SW:RPC1_BPPH8 (EMBL:X13065) bacteriophage phi-80 repressor protein (235 aa), fasta scores; E(): 5.9e-11, 30.3% identity in 234 aa overlap. Also similar to other transcriptional regulators e.g. SW:PRTR_PSEAE (EMBL:D12706), prtR, Pseudomonas aeruginosa pyosin repressor protein (256 aa), fasta scores; E(): 2.5e-05,26.7% identity in 247 aa overlap. Similar to NMA1884,fasta scores; E(): 0, 53.4% identity in 232 aa overlap; transcriptional regulator 732438..733124 Neisseria meningitidis Z2491 906729 YP_002342192.1 CDS NMA0739 NC_003116.1 733256 733594 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 733256..733594 Neisseria meningitidis Z2491 906730 YP_002342193.1 CDS NMA0740 NC_003116.1 733754 734218 D NMA0740, len: 154 aa; unknown; hypothetical protein 733754..734218 Neisseria meningitidis Z2491 906731 YP_002342194.1 CDS ubiB NC_003116.1 734253 735764 D an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 734253..735764 Neisseria meningitidis Z2491 906732 YP_002342195.1 CDS NMA0742 NC_003116.1 736121 736939 R NMA0742, cysE, probable serine acetyltransferase,len: 272 aa; similar to many e.g. SW:CYSE_ECOLI (EMBL:M15745), cysE, Escherichia coli serine acetyltransferase (EC 2.3.1.30) (273 aa), fasta scores; E(): 0, 57.0% identity in 251 aa overlap. Contains Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) and PS00101 Hexapeptide-repeat containing-transferases signature; serine acetyltransferase complement(736121..736939) Neisseria meningitidis Z2491 906733 YP_002342196.1 CDS NMA0744 NC_003116.1 737123 737701 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 737123..737701 Neisseria meningitidis Z2491 906734 YP_002342197.1 CDS NMA0745 NC_003116.1 737825 738040 R NMA0745, periplasmic protein, len: 71 aa; similar to SW:Y173_HAEIN (EMBL:U32702) Haemophilus influenzae hypothetical protein (86 aa), fasta scores; E(): 1.5e-10, 50.8% identity in 65 aa overlap. Contains a N-terminal signal sequence; hypothetical protein complement(737825..738040) Neisseria meningitidis Z2491 906735 YP_002342198.1 CDS NMA0746 NC_003116.1 738066 739121 R NMA0746, apbE, probable thiamine biosynthesis protein, len: 351 aa; similar to e.g. SW:APBE_SALTY (EMBL:AF035376), apbE, Salmonella typhimurium thiamine biosynthesis lipoprotein apbE precursor (350 aa), fasta scores; E(): 0, 38.7% identity in 349 aa overlap. Contains a probable N-terminal signal sequence; thiamine biosynthesis protein complement(738066..739121) Neisseria meningitidis Z2491 906736 YP_002342199.1 CDS nqrF NC_003116.1 739274 740491 R uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit F complement(739274..740491) Neisseria meningitidis Z2491 906737 YP_002342200.1 CDS nqrE NC_003116.1 740505 741098 R Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.; Na(+)-translocating NADH-quinone reductase subunit E complement(740505..741098) Neisseria meningitidis Z2491 906738 YP_002342201.1 CDS nqrD NC_003116.1 741102 741728 R Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit D complement(741102..741728) Neisseria meningitidis Z2491 906739 YP_002342202.1 CDS nqrC NC_003116.1 741728 742504 R uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit C complement(741728..742504) Neisseria meningitidis Z2491 906740 YP_002342203.1 CDS nqrB NC_003116.1 742497 743729 R uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit B complement(742497..743729) Neisseria meningitidis Z2491 906741 YP_002342204.1 CDS nqrA NC_003116.1 743732 745075 R uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit A complement(743732..745075) Neisseria meningitidis Z2491 906742 YP_002342205.1 CDS NMA0753 NC_003116.1 745423 746844 R NMA0753, membrane protein, len: 473 aa; shows very weak similarity to SW:Y753_SYNY3 (EMBL:D90917) Synechocystis sp. (strain PCC 6803) hypothetical membrane protein (449 aa), fasta scores; E(): 1.7e-05, 23.9% identity in 481 aa overlap. Contains hydrophobic, membrane-spanning regions; hypothetical protein complement(745423..746844) Neisseria meningitidis Z2491 906743 YP_002342206.1 CDS NMA0754 NC_003116.1 747202 747561 R NMA0754, membrane protein, len: 119 aa; similar to SW:YBAN_ECOLI (EMBL:AE000153), ybaN,Escherichia coli hypothetical protein, len: 125 aa, fasta scores; E(): 6.4e-17, 41.0% identity in 117 aa overlap and TR:Q51668 (EMBL:U34346) Paracoccus denitrificans hypothetical protein (fragment) (115 aa), fasta scores; E(): 8.5e-15, 36.5% identity in 115 aa overlap. Contains hydrophobic, membrane-spanning region; hypothetical protein complement(747202..747561) Neisseria meningitidis Z2491 906744 YP_002342207.1 CDS NMA0755 NC_003116.1 747558 748163 R NMA0755, len: 201 aa; unknown; hypothetical protein complement(747558..748163) Neisseria meningitidis Z2491 906745 YP_002342208.1 CDS NMA0756 NC_003116.1 748210 748692 R NMA0756, probable AsnC-family transcriptional regulator, len: 160 aa; similar to many e.g. SW:BKDR_PSEPU (EMBL:M57613), bkdR, Pseudomonas putida branched-chain keto acid dehydrogenase complex operon transcriptional regulator (161 aa), fasta scores; E(): 1.2e-23, 43.3% identity in 150 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg, AsnC family; AsnC-family transcriptional regulator complement(748210..748692) Neisseria meningitidis Z2491 906746 YP_002342209.1 CDS gcvT NC_003116.1 749198 750304 D catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 749198..750304 Neisseria meningitidis Z2491 906748 YP_002342210.1 CDS gcvH NC_003116.1 750467 750853 D part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 750467..750853 Neisseria meningitidis Z2491 906749 YP_002342211.1 CDS hemA NC_003116.1 751005 752252 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 751005..752252 Neisseria meningitidis Z2491 906750 YP_002342212.1 CDS NMA0761 NC_003116.1 752579 753100 D NMA0761, regulatory protein, len: 173 aa; similar to the N-termini of several nosR proteins e.g. TR:O68483 (EMBL:AF047430), nosR, Sinorhizobium meliloti regulatory protein (755 aa), fasta scores; E(): 1.8e-12,38.3% identity in 115 aa overlap; regulatory protein 752579..753100 Neisseria meningitidis Z2491 906751 YP_002342213.1 CDS NMA0762 NC_003116.1 753154 754188 D NMA0762, hypothetical protein, len: 344 aa; unknown function, similar to part of several nosD proteins e.g. SW:NOSD_PSEST (EMBL:X53676), nosD, Pseudomonas stutzeri copper-binding periplasmic protein precursor (436 aa),fasta scores; E(): 9.8e-29, 39.0% identity in 331 aa overlap; hypothetical protein 753154..754188 Neisseria meningitidis Z2491 906752 YP_002342214.1 CDS NMA0763 NC_003116.1 754216 754866 D NMA0763, probable ABC-transporter ATP-binding protein, len: 216 aa; similar to many ABC-transporter ATP-binding proteins e.g. SW:NOSF_PSEST (EMBL:X53676),nosF, Pseudomonas stutzeri copper transport ATP-binding protein (308 aa), fasta scores; E(): 5.2e-33, 50.5% identity in 200 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); ABC transporter ATP-binding protein 754216..754866 Neisseria meningitidis Z2491 906753 YP_002342215.1 CDS NMA0765 NC_003116.1 755084 755578 D NMA0765, lipoprotein, len: 164 aa; similar to several nosL proteins e.g. TR:O07331 (EMBL:U94899),nosL, Sinorhizobium meliloti outer-membrane lipoprotein (185 aa), fasta scores; E(): 2.4e-27, 45.1% identity in 164 aa overlap. Contains probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 755084..755578 Neisseria meningitidis Z2491 906755 YP_002342216.1 CDS NMA0766 NC_003116.1 755666 757327 R NMA0766, probable electron transfer flavoprotein-ubiquinone oxidoreductase, len: 553 aa; similar to many eukaryotic enzymes e.g. SW:ETFD_HUMAN (EMBL:S69232), etfdH, Homo sapiens electron transfer flavoprotein-ubiquinone oxidoreductase precursor (EC 1.5.5.1) (617 aa), fasta scores; E(): 0, 56.6% identity in 558 aa overlap. Also shows weaker similarity to several bacterial fixC proteins e.g. SW:FIXC_AZOCA (EMBL:X55450),fixC, Azorhizobium caulinodans electron transfer quinone reductase (435 aa), fasta scores; E(): 3.4e-11,24.6% identity in 398 aa overlap; electron transfer flavoprotein-ubiquinone oxidoreductase complement(755666..757327) Neisseria meningitidis Z2491 906756 YP_002342217.1 CDS NMA0767 NC_003116.1 757457 757873 R NMA0767, unknown, len: 138 aa; shows weak similarity to part of TR:O53037 (EMBL:U68399), hmcC,Haemophilus influenzae protein implicated in haemocin production (198 aa), fasta scores; E(): 1.1e-06, 30.9% identity in 110 aa overlap. Also highly similar to other proteins from Neisseria meningitidis, NMA0173, fasta scores; 70.7% identity in 164 aa overlap and NMA1066,fasta scores; 88.3% identity in 128 aa overlap; hypothetical protein complement(757457..757873) Neisseria meningitidis Z2491 906757 YP_002342218.1 CDS NMA0768 NC_003116.1 758873 759838 D NMA0768, probable transposase for IS1655, len: 321 aa; similar to many e.g. SW:TRA4_BACFR (EMBL:M17808) Bacteroides fragilis transposase for insertion sequence element (326 aa), fasta scores; E(): 0, 41.6% identity in 310 aa overlap. Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family. Contains probable helix-turn-helix motif at aa 22-34 (Score 1705, +4.99 SD); transposase for IS1655 758873..759838 Neisseria meningitidis Z2491 906758 YP_002342219.1 CDS NMA0769 NC_003116.1 760370 761023 R NMA0769, transposase for IS1016, len: 217 aa; similar to many e.g. TR:Q48234 (EMBL:X59756) ORF from Haemophilus influenzae insertion sequence IS1016-V6 (191 aa), fasta scores; E(): 0, 66.5% identity in 188 aa overlap; transposase for IS1016 complement(760370..761023) Neisseria meningitidis Z2491 906759 YP_002342220.1 CDS NMA0772 NC_003116.1 761709 762674 R NMA0772, probable DNA-invertase, len: 321 aa; similar to site-specific pilin-gene invertases from Moraxella e.g. SW:PIV_MORBO (EMBL:M32345), piv, Moraxella bovis pilin gene inverting protein (322 aa), fasta scores; E(): 2.8e-23, 30.0% identity in 320 aa overlap. Also similar to TR:P72078 (EMBL:U65994) Neisseria gonorrhoeae pilin gene inverting protein homolog (320 aa), fasta scores; E(): 0, 47.1% identity in 323 aa overlap. Similar to others from Neisseria meningitidis e.g. NMA1800 (318 aa), fasta scores; E(): 0, 40.9% identity in 318 aa overlap. Contains Pfam match to entry PF01548 Transposase_9, Transposase; DNA-invertase complement(761709..762674) Neisseria meningitidis Z2491 906762 YP_002342221.1 CDS NMA0773 NC_003116.1 762890 763138 D NMA0773, len: 82 aa; unknown; hypothetical protein 762890..763138 Neisseria meningitidis Z2491 906763 YP_002342222.1 CDS NMA0774 NC_003116.1 763535 764593 R NMA0774, unknown, len: 352 aa; similar to hypothetical proteins from bacteriophage and plasmids e.g. TR:O82966 (EMBL:AB015669) ORFC6 from Burkholderia solanacearum plasmid pJTPS1 (364 aa), fasta scores; E(): 9.7e-24, 30.9% identity in 366 aa overlap and TR:Q38198 (EMBL:M57538) unknown protein from bacteriophage Cf1c (388 aa), fasta scores; E(): 1.2e-16, 25.5% identity in 357 aa overlap. Similar to NMA1799, fasta scores; E(): 0, 40.4% identity in 369 aa overlap. Contains 2 PS00017 ATP/GTP-binding site motif A (P-loop), which may be fortuitous; hypothetical protein complement(763535..764593) Neisseria meningitidis Z2491 906764 YP_002342223.1 CDS NMA0775 NC_003116.1 764596 764883 R NMA0775, integral membrane protein, len: 95 aa; unknown, shows weak similarity to NMA1798, fasta scores; E(): 4.5e-07, 34.8% identity in 92 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein complement(764596..764883) Neisseria meningitidis Z2491 906765 YP_002342224.1 CDS NMA0776 NC_003116.1 764885 766399 R NMA0776, probable cell-surface protein, len; 504 aa; highly similar to TR:O87783 (EMBL:AJ010115), tspB,Neisseria meningitidis strain B:15:P1.16 T-cell and B-cell antigen (partial CDS) (504 aa), fasta scores; E(): 0,54.8% identity in 485 aa overlap. Similar to others from Neisseria meningitidis, NMA1797, fasta scores; E(): 0,58.4% identity in 474 aa overlap, NMA1173, fasta scores; E(): 2.9e-21, 51.0% identity in 145 aa overlap and NMA2005, fasta scores; E(): 8.6e-19, 61.5% identity in 96 aa overlap. Contains a probable N-terminal signal sequence; cell-surface protein complement(764885..766399) Neisseria meningitidis Z2491 906766 YP_002342225.1 CDS NMA0777 NC_003116.1 766341 766646 R NMA0777, len: 101 aa; unknown, similar to others from Neisseria meningitidis, NMA1172, fasta scores; E(): 5.1e-16, 57.5% identity in 73 aa overlap and NMA2004,fasta scores; E(): 1.8e-14, 47.6% identity in 105 aa overlap; hypothetical protein complement(766341..766646) Neisseria meningitidis Z2491 906767 YP_002342226.1 CDS NMA0778 NC_003116.1 766775 767050 R NMA0778, unknown, len: 91 aa; shows weak similarity to TR:O82955 (EMBL:AB015669) ORF C4 from Burkholderia solanacearum plasmid pJTPS1 (111 aa), fasta scores; E(): 0.0061, 26.0% identity in 104 aa overlap. Similar to others from Neisseria meningitidis, NMA1171, fasta scores; E(): 3.1e-25, 58.7% identity in 92 aa overlap, NMA2003,fasta scores; E(): 3.1e-25, 58.7% identity in 92 aa overlap and NMA1796, fasta scores; E(): 5.9e-10, 30.4% identity in 92 aa overlap; hypothetical protein complement(766775..767050) Neisseria meningitidis Z2491 906768 YP_002342227.1 CDS NMA0779 NC_003116.1 767061 767279 R NMA0779, integral membrane protein, len: 72 aa; similar to TR:O88142 (EMBL:AB012574), vpf77,hypothetical protein from Vibrio parahaemolyticus filamentous bacteriophage Vf12 (77 aa), fasta scores; E(): 0.64, 32.0% identity in 75 aa overlap. Similar to others from Neisseria meningitidis, NMA2002, fasta scores; E(): 2.8e-18, 72.2% identity in 72 aa overlap and NMA1170,fasta scores; E(): 2.8e-18, 72.2% identity in 72 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein complement(767061..767279) Neisseria meningitidis Z2491 906769 YP_002342228.1 CDS NMA0780 NC_003116.1 767362 767565 R NMA0780, len: 67 aa; unknown, similar to others from Neisseria meningitidis, NMA1794, fasta scores; E(): 2.6e-20, 58.5% identity in 65 aa overlap and NMA1169,fasta scores; E(): 3e-07, 36.1% identity in 61 aa overlap and NMA2001, fasta scores; E(): 3e-07, 36.1% identity in 61 aa overlap; hypothetical protein complement(767362..767565) Neisseria meningitidis Z2491 906770 YP_002342229.1 CDS NMA0781 NC_003116.1 767583 767894 R NMA0781, len: 103 aa; unknown, similar to others from Neisseria meningitidis, NMA1793, fasta scores; E(): 2.6e-30, 70.1% identity in 97 aa overlap, NMA1168, fasta scores; E(): 4.9e-11, 34.9% identity in 83 aa overlap and NMA2000, fasta scores; E(): 4.9e-11, 34.9% identity in 83 aa overlap; hypothetical protein complement(767583..767894) Neisseria meningitidis Z2491 906771 YP_002342230.1 CDS NMA0782 NC_003116.1 767915 769264 R NMA0782, phage replication protein, len: 449 aa; shows weak similarity to e.g. TR:O34630 (EMBL:U83796) rstA2, Vibrio cholerae bacteriophage CTXphi protein required for replication and integration (359 aa),fasta scores; E(): 4.5e-10, 27.0% identity in 296 aa overlap. Also similar to TR:O82959 (EMBL:AB015669) ORF C7 from Burkholderia solanacearum plasmid pJTPS1 (444 aa),fasta scores; E (): 3.4e-15, 31.6% identity in 326 aa overlap. Similar to others from Neisseria meningitidis,NMA1792, E(): 0, 50.4% identity in 407 aa overlap,NMA1999, fasta scores; E(): 0, 42.7% identity in 337 aa overlap, and NMA1167, fasta scores; E(): 0, 42.7% identity in 337 aa overlap; phage replication protein complement(767915..769264) Neisseria meningitidis Z2491 906772 YP_002342231.1 CDS NMA0783 NC_003116.1 769261 769476 R NMA0783, len: 71 aa; unknown; hypothetical protein complement(769261..769476) Neisseria meningitidis Z2491 906773 YP_002342232.1 CDS NMA0784 NC_003116.1 769762 770283 D NMA0784, membrane protein, len: 173 aa; unknown, similar to others from Neisseria meningitidis,NMA1989, fasta scores; E(): 0, 82.7% identity in 173 aa overlap and NMA0786, fasta scores; E(): 0, 50.0% identity in 168 aa overlap. Within a region of unusually low GC content. Contains hydrophobic, membrane-spanning regions; membrane protein 769762..770283 Neisseria meningitidis Z2491 906774 YP_002342233.1 CDS NMA0785 NC_003116.1 770333 770782 D NMA0785, len: 149 aa; unknown, similar to the N-terminal half of NMA0787, fasta scores; E(): 4.3e-33,73.5% identity in 132 aa overlap. Within a region of unusually low GC content; hypothetical protein 770333..770782 Neisseria meningitidis Z2491 906775 YP_002342234.1 CDS NMA0786 NC_003116.1 770816 771322 D NMA0786, membrane protein, len: 168 aa; unknown, similar to NMA0784, fasta scores; E(): 0, 50.0% identity in 168 aa overlap and NMA1989, fasta scores; E(): 0, 47.6% identity in 168 aa overlap. Within a region of unusually low GC content. Contains hydrophobic, membrane-spanning regions; membrane protein 770816..771322 Neisseria meningitidis Z2491 906776 YP_002342235.1 CDS NMA0789 NC_003116.1 774834 775760 R NMA0789, probable periplasmic binding protein, len: 308 aa; similar to binding protein components of ABC-transporters and to other binding proteins such as adhesins e.g. SW:ZNUA_ECOLI (EMBL:U38702), znuA,Escherichia coli high-affinity zinc uptake system component (328 aa), fasta scores; E(): 1.4e-13, 27.1% identity in 292 aa overlap and SW:ADHS_STRPA (EMBL:M26130), fimA, Streptococcus parasanguis adhesin B precursor (309 aa), fasta scores; E(): 1.2e-13, 26.0% identity in 304 aa overlap. Contains HD repeats from aa 115-134. Contains Pfam match to entry PF01297 Lipoprotein_4, Adhesion lipoprotein and probable N-terminal signal sequence; periplasmic binding protein complement(774834..775760) Neisseria meningitidis Z2491 906779 YP_002342236.1 CDS NMA0790 NC_003116.1 775837 776712 R NMA0790, probable ABC-transporter membrane protein,len: 291 aa; similar to many e.g. SW:MNTB_SYNY3 (EMBL:L34630), mntB, Synechocystis sp. (strain PCC 6803) manganese transport system membrane protein (306 aa),fasta scores; E(): 2.7e-21, 27.9% identity in 280 aa overlap. Contains Pfam match to entry PF00950 ABC-3, ABC 3 transport family and contains hydrophobic, membrane-spanning regions; ABC-transporter membrane protein complement(775837..776712) Neisseria meningitidis Z2491 906780 YP_002342237.1 CDS NMA0791 NC_003116.1 776748 777503 R NMA0791, probable ABC-transporter ATP-binding protein, len: 251 aa; similar to many e.g. SW:MNTA_SYNY3 (EMBL:L34630), mntA, Synechocystis sp. (strain PCC 6803) manganese transport system ATP-binding protein (260 aa),fasta scores; E(): 2.7e-27, 38.8% identity in 232 aa overlap. Contains Pfam match to entry PF00005 ABC_tran,ABC transporter and PS00017 ATP/GTP-binding site motif A (P-loop); ABC transporter ATP-binding protein complement(776748..777503) Neisseria meningitidis Z2491 906781 YP_002342238.1 CDS rplS NC_003116.1 777791 778156 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(777791..778156) Neisseria meningitidis Z2491 906782 YP_002342239.1 CDS trmD NC_003116.1 778172 778921 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(778172..778921) Neisseria meningitidis Z2491 906783 YP_002342240.1 CDS rimM NC_003116.1 778921 779430 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(778921..779430) Neisseria meningitidis Z2491 906784 YP_002342241.1 CDS rpsP NC_003116.1 779446 779691 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(779446..779691) Neisseria meningitidis Z2491 906785 YP_002342242.1 CDS NMA0796 NC_003116.1 779736 782162 R NMA0796, unknown, len: 808 aa; shows weak similarity in the N-terminal half to acyl-CoA synthetases e.g. TR:Q9ZER2 (EMBL:AJ012480) Pseudomonas mendocina pimeloyl-CoA synthetase (711 aa), fasta scores; E(): 3.3e-07, 22.0% identity in 496 aa overlap. Also similar to in part to many hypothetical proteins. The C-terminus contains a Pfam match to entry PF00583 Acetyltransf,Acetyltransferase (GNAT) family; hypothetical protein complement(779736..782162) Neisseria meningitidis Z2491 906786 YP_002342243.1 CDS NMA0797 NC_003116.1 782280 783686 R NMA0797, probable two-component system sensor kinase, len: 468 aa; similar to many e.g. SW:BAES_ECOLI (EMBL:D14054), baeS, Escherichia coli sensor protein (EC 2.7.3.-) (467 aa), fasta scores; E(): 1.1e-21, 28.0% identity in 300 aa overlap. Contains Pfam matches to entry PF00512 signal, Signal carboxyl-terminal domain and to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains hydrophobic, probable membrane-spanning regions; two-component system sensor kinase complement(782280..783686) Neisseria meningitidis Z2491 906787 YP_002342244.1 CDS NMA0798 NC_003116.1 783700 784377 R NMA0798, probable two-component system regulator,len: 225 aa; similar to many e.g. SW:OMPR_ECOLI (EMBL:J01656), ompR, Escherichia coli transcriptional regulatory protein (239 aa), fasta scores; E(): 1.7e-28,41.8% identity in 232 aa overlap. Contains Pfam matches to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal and to entry PF00072 response_reg,Response regulator receiver domain; two-component system regulator complement(783700..784377) Neisseria meningitidis Z2491 906788 YP_002342245.1 CDS NMA0800 NC_003116.1 784567 786381 R NMA0800, integral membrane protein, len: 604 aa; unknown, shows very weak similarity to the N-terminal half of TR:AAD35888 (EMBL:AE001748) Thermotoga maritima hypothetical protein (1065 aa), fasta scores; E(): 0.014, 21.7% identity in 465 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein complement(784567..786381) Neisseria meningitidis Z2491 906790 YP_002342246.1 CDS NMA0801 NC_003116.1 786371 786724 R NMA0801, len: 117 aa; unknown; hypothetical protein complement(786371..786724) Neisseria meningitidis Z2491 906791 YP_002342247.1 CDS NMA0802 NC_003116.1 786740 787345 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(786740..787345) Neisseria meningitidis Z2491 906792 YP_002342248.1 CDS NMA0803 NC_003116.1 787398 788168 R NMA0803, tatC, probable sec-independent protein translocase component, len: 256 aa; similar to many e.g. SW:TATC_ECOLI (EMBL:AJ005830), tatC, mttB, Escherichia coli sec-independent protein translocase (258 aa),fasta scores; E(): 0, 50.2% identity in 247 aa overlap. Contains Pfam match to entry PF00902 UPF0032, MttB family. Contains hydrophobic, membrane-spanning regions; sec-independent protein translocase component complement(787398..788168) Neisseria meningitidis Z2491 906793 YP_002342249.1 CDS NMA0804 NC_003116.1 788182 788868 R NMA0804, sec-independent protein translocase component, len: 228 aa; the hydrophobic N-terminus is similar to the N-terminus of TR:O69415 (EMBL:AJ005830), tatB, Escherichia coli sec-independent protein translocase component (171 aa), fasta scores; E(): 0.0011, 38.6% identity in 70 aa overlap. This region is also similar to N-termini from several hypothetical proteins; sec-independent protein translocase component complement(788182..788868) Neisseria meningitidis Z2491 906794 YP_002342250.1 CDS NMA0806 NC_003116.1 789122 789445 R NMA0806, nucleotide-binding protein, len: 107 aa; similar to members of the HIT (histidine triad) family e.g. SW:IPK1_RABIT (EMBL:Y11175), hinT, Oryctolagus cuniculus HinT protein (125 aa), fasta scores; E(): 5e-15,40.2% identity in 102 aa overlap. Highly similar to SW:HITA_NEIGO (EMBL:AF003550), hitA, Neisseria gonorrhoeae HitA protein (107 aa), fasta scores; E(): 0, 96.3% identity in 107 aa overlap. Contains Pfam match to entry PF01230 HIT, HIT family and PS00892 HIT family signature; nucleotide-binding protein complement(789122..789445) Neisseria meningitidis Z2491 906796 YP_002342251.1 CDS hisE NC_003116.1 789517 789840 R catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase complement(789517..789840) Neisseria meningitidis Z2491 906797 YP_002342252.1 CDS NMA0808 NC_003116.1 789981 791045 R NMA0808, probable zinc-binding alcohol dehydrogenase, len: 354 aa; similar to many e.g. TR:Q59696 (EMBL:L35343), adh, Pseudomonas putida 2,3-butanediol dehydrogenase (EC 1.1.1.4) (362 aa), fasta scores; E(): 0,38.2% identity in 356 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases and PS00059 Zinc-containing alcohol dehydrogenases signature; zinc-binding alcohol dehydrogenase complement(789981..791045) Neisseria meningitidis Z2491 906798 YP_002342253.1 CDS NMA0810 NC_003116.1 791408 792565 R NMA0810, len: 385 aa; unknown, similar to members of the histone deacetylase/acetoin utilization/acetylpolyamine aminohydrolase family e.g. SW:Y245_SYNY3 (EMBL:D90900) Synechocystis sp. (strain PCC 6803) hypothetical protein (304 aa), fasta scores; E(): 8.2e-33, 35.7% identity in 300 aa overlap. Contains Pfam match to entry PF00850 Hist_deacetyl, Histone deacetylase family; hypothetical protein complement(791408..792565) Neisseria meningitidis Z2491 906799 YP_002342254.1 CDS NMA0811 NC_003116.1 792645 792911 D NMA0811, len: 88 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YAJC_ECOLI (EMBL:EG11096),yajC, Escherichia coli hypothetical protein (110 aa),fasta scores; E(): 6.9e-07, 35.2% identity in 88 aa overlap; hypothetical protein 792645..792911 Neisseria meningitidis Z2491 906800 YP_002342255.1 CDS secD NC_003116.1 793120 794976 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 793120..794976 Neisseria meningitidis Z2491 906801 YP_002342256.1 CDS secF NC_003116.1 794980 795915 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 794980..795915 Neisseria meningitidis Z2491 906802 YP_002342257.1 CDS rpsO NC_003116.1 796138 796407 D primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 796138..796407 Neisseria meningitidis Z2491 906804 YP_002342258.1 CDS NMA0816 NC_003116.1 796788 797912 D NMA0816, probable polyamine permease ATP-binding protein, len: 374 aa; similar to ATP-binding components of many polyamine permeases e.g. SW:POTG_ECOLI (EMBL:M93239),potG, Escherichia coli putrescine transport ATP-binding protein (404 aa), fasta scores; E(): 0, 54.2% identity in 395 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); polyamine permease ATP-binding protein 796788..797912 Neisseria meningitidis Z2491 906805 YP_002342259.1 CDS NMA0817 NC_003116.1 797928 798893 D NMA0817, probable polyamine permease inner membrane protein, len: 321 aa; similar to inner membrane components from many polyamine permeases e.g. SW:POTH_ECOLI (EMBL:M93239), potH, Escherichia coli putrescine transport system permease (317 aa), fasta scores; E(): 0,49.2% identity in 311 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains hydrophobic, probable membrane-spanning regions; polyamine permease inner membrane protein 797928..798893 Neisseria meningitidis Z2491 906806 YP_002342260.1 CDS NMA0818 NC_003116.1 798893 799780 D NMA0818, probable polyamine permease inner membrane protein, len: 295 aa; similar to inner membrane components from many polyamine permeases e.g. SW:POTI_ECOLI (EMBL:M93239), potI, Escherichia coli putrescine transport system permease (281 aa), fasta scores; E(): 0,54.7% identity in 278 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains hydrophobic, probable membrane-spanning regions; polyamine permease inner membrane protein 798893..799780 Neisseria meningitidis Z2491 906807 YP_002342261.1 CDS NMA0819 NC_003116.1 799906 801201 D NMA0819, oxidoreductase, len: 431 aa; shows very weak similarity to several known oxidoreductases e.g. SW:SAOX_CORS1 (EMBL:U23955), soxB,Corynebacterium sp. sarcosine oxidase beta subunit (EC 1.5.3.1) (405 aa), fasta scores; E(): 6.8e-05, 23.7% identity in 414 aa overlap. Also similar to SW:ORDL_ECOLI (EMBL:U38543), ordL, Escherichia coli probable oxidoreductase (426 aa), fasta scores; E(): 0, 46.2% identity in 433 aa overlap; oxidoreductase 799906..801201 Neisseria meningitidis Z2491 906808 YP_002342262.1 CDS NMA0820 NC_003116.1 801446 802750 R NMA0820, amtB, probable ammonium transporter, len: 434 aa; similar to many of bacterial and eukaryotic origin e.g. TR:O67997 (EMBL:AF005275), amtB, Azospirillum brasilense (Methyl)ammonium transporter (438 aa), fasta scores; E(): 0, 54.7% identity in 428 aa overlap. Contains Pfam match to entry PF00909 Ammonium_transp, Ammonium Transporter Family and PS01219 Ammonium transporters signature. Contains hydrophobic, membrane-spanning regions; ammonium transporter complement(801446..802750) Neisseria meningitidis Z2491 906809 YP_002342263.1 CDS rho NC_003116.1 805239 806498 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(805239..806498) Neisseria meningitidis Z2491 906814 YP_002342264.1 CDS ppsA NC_003116.1 806718 809102 R catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase complement(806718..809102) Neisseria meningitidis Z2491 906815 YP_002342265.1 CDS NMA0827 NC_003116.1 809514 810335 D NMA0827, len: 273 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YDIA_ECOLI (EMBL:AE000265) Escherichia coli hypothetical protein (277 aa), fasta scores; E(): 0, 47.4% identity in 270 aa overlap and to the C-terminal half of TR:O49562 (EMBL:AL021960) Arabidopsis thaliana hypothetical protein (403 aa), fasta scores; E(): 3.1e-16, 27.8% identity in 288 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 809514..810335 Neisseria meningitidis Z2491 906816 YP_002342266.1 CDS NMA0828 NC_003116.1 810575 811237 R NMA0828, probable phosphatase, len: 220 aa; similar to many e.g. SW:GPHP_ALCEU (EMBL:M68905), cbbzP,Alcaligenes eutrophus phosphoglycolate phosphatase (231 aa), fasta scores; E(): 1.4e-13, 32.3% identity in 192 aa overlap and to phosphatases found within polyketide biosynthesis operons e.g. TR:AAD31837 (EMBL:AF131879), ansH, Streptomyces collinus phosphatase (268 aa), fasta scores; E(): 1.1e-11, 30.1% identity in 216 aa overlap. Also similar to NMA1688, fasta scores; E(): 2e-11, 27.8% identity in 227 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase; phosphatase complement(810575..811237) Neisseria meningitidis Z2491 906817 YP_002342267.1 CDS NMA0829 NC_003116.1 811250 812077 R NMA0829, len: 275 aa; unknown, similar to SW:Y077_HAEIN (EMBL:U32693) Haemophilus influenzae hypothetical protein (288 aa), fasta scores; E(): 0, 48.9% identity in 272 aa overlap; hypothetical protein complement(811250..812077) Neisseria meningitidis Z2491 906818 YP_002342268.1 CDS NMA0830 NC_003116.1 812507 813130 D NMA0830, periplasmic carrier protein, len: 207 aa; similar to e.g. SW:LOLA_ECOLI (EMBL:D49398), lolA,Escherichia coli outer membrane lipoproteins carrier protein precursor (204 aa), fasta scores; E(): 2.2e-11,29.4% identity in 197 aa overlap. Contains a N-terminal signal sequence; periplasmic carrier protein 812507..813130 Neisseria meningitidis Z2491 906819 YP_002342269.1 CDS NMA0831 NC_003116.1 813403 814542 D NMA0831, polyamine permease substrate-binding protein, len: 379 aa; similar to SW:POTF_ECOLI (EMBL:M93239), potF, Escherichia coli putrescine-binding periplasmic protein precursor (370 aa),fasta scores; E(): 0, 40.8% identity in 346 aa overlap. Also similar to NMA1786, fasta scores; E(): 0, 60.8% identity in 380 aa overlap and NMA2023, fasta scores; E(): 0, 54.8% identity in 396 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; polyamine permease substrate-binding protein 813403..814542 Neisseria meningitidis Z2491 906820 YP_002342270.1 CDS NMA0832 NC_003116.1 814675 815826 D NMA0832, glycosyl transferase, len: 383 aa; shows very weak similarity to several glycosyltransferases (some ) associated with capsule polysaccharide formation in pathogenic bacteria e.g. TR:AAD24457 (EMBL:AF118389), cps2K, Streptococcus suis glycosyl transferase (276 aa), fasta scores; E(): 1.6e-07, 25.7% identity in 335 aa overlap. Contains 9x NNKQQTT repeats and has an unusually low GC content (31%). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; glycosyl transferase family protein 814675..815826 Neisseria meningitidis Z2491 906821 YP_002342271.1 CDS NMA0833 NC_003116.1 815867 816397 D NMA0833, len: 176 aa; unknown, similar to many hypothetical proteins e.g. part of SW:YRDA_ECOLI (EMBL:U18997) Escherichia coli hypothetical protein (256 aa), fasta scores; E(): 0, 62.4% identity in 173 aa overlap and to part of SW:CAIE_ECOLI (EMBL:X73904), caiE,Escherichia coli carnitine operon protein (203 aa), fasta scores; E(): 6.3e-16, 34.1% identity in 164 aa overlap. Contains a weak Pfam matches to entry PF00132 hexapep,Bacterial transferase hexapeptide (four repeats); hypothetical protein 815867..816397 Neisseria meningitidis Z2491 906822 YP_002342272.1 CDS prfC NC_003116.1 816773 818368 R stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 complement(816773..818368) Neisseria meningitidis Z2491 906824 YP_002342273.1 CDS hisI NC_003116.1 818475 818870 R PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase complement(818475..818870) Neisseria meningitidis Z2491 906825 YP_002342274.1 CDS hisF NC_003116.1 818901 819668 R catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF complement(818901..819668) Neisseria meningitidis Z2491 906826 YP_002342275.1 CDS hisA NC_003116.1 819681 820418 R catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase complement(819681..820418) Neisseria meningitidis Z2491 906827 YP_002342276.1 CDS hisH NC_003116.1 820451 821089 R with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH complement(820451..821089) Neisseria meningitidis Z2491 906828 YP_002342277.1 CDS NMA0841 NC_003116.1 821220 822722 R NMA0841, probable phosphate acyltransferase, len: 500 aa; similar to many phosphate acetyltransferases,except over the N-terminal approx. 200 aa e.g. SW:PTA_ECOLI (EMBL:D17576), pta, Escherichia coli phosphate acetyltransferase (EC 2.3.1.8) (713 aa), fasta scores; E(): 0, 67.6% identity in 346 aa overlap. Contains Pfam match to entry PF01515 PTA_PTB, Phosphate acetyl/butaryl transferase; phosphate acyltransferase complement(821220..822722) Neisseria meningitidis Z2491 906829 YP_002342278.1 CDS NMA0842 NC_003116.1 822907 823965 R NMA0842, fbpC, probable iron-uptake permease ATP-binding protein, len: 352 aa; similar to many ABC-transporter ATP-binding proteins involved in iron uptake e.g. TR:Q50966 (EMBL:U33937), fpbC, Neisseria gonorrhoeae iron-regulated protein (352 aa), fasta scores; E(): 0, 93.5% identity in 352 aa overlap and SW:SFUC_SERMA (EMBL:M33815), sfuC, Serratia marcescens iron(III)-transport ATP-binding protein (345 aa), fasta scores; E(): 0, 41.8% identity in 352 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter,PS00211 ABC transporters family signature and two PS00017 ATP/GTP-binding site motif A (P-loop); iron-uptake permease ATP-binding protein complement(822907..823965) Neisseria meningitidis Z2491 906830 YP_002342279.1 CDS NMA0843 NC_003116.1 823986 825515 R NMA0843, fbpB, probable iron-uptake permease inner membrane protein, len: 509 aa; similar to many binding protein dependent permease components e.g. TR:Q50965 (EMBL:U33937), fbpB, Neisseria gonorrhoeae iron-regulated protein (511 aa), fasta scores; E(): 0, 89.8% identity in 512 aa overlap and SW:SFUB_SERMA (EMBL:M33815), sfuB,Serratia marcescens iron(III)-transport system permease (527 aa), fasta scores; E(): 0, 36.6% identity in 497 aa overlap. Contains two Pfam matches to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains hydrophobic, probable membrane-spanning regions; iron-uptake permease inner membrane protein complement(823986..825515) Neisseria meningitidis Z2491 906831 YP_002342280.1 CDS NMA0844 NC_003116.1 825571 826566 R NMA0844, fbpA, major ferric iron binding protein,len: 331 aa; highly similar to many e.g. SW:FBP_NEIME (EMBL:X53467), fbpA, Neisseria meningitidis major ferric iron binding protein (330 aa), fasta scores; E(): 0, 98.8% identity in 331 aa overlap and probably constitutes the periplasmic binding component of an iron permease. Contains a probable N-terminal signal sequence; major ferric iron binding protein complement(825571..826566) Neisseria meningitidis Z2491 906832 YP_002342281.1 CDS NMA0846 NC_003116.1 826817 827286 R NMA0846; unknown, fused with NMA0845 in MC58 and FAM18; hypothetical protein complement(join(826817..827062,827062..827286)) Neisseria meningitidis Z2491 906834 YP_002342282.1 CDS argH NC_003116.1 827343 828719 R catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase complement(827343..828719) Neisseria meningitidis Z2491 906835 YP_002342283.1 CDS NMA0848 NC_003116.1 828738 829607 R NMA0848, galU, probable UTP--glucose-1-phosphate uridylyltransferase, len: 289 aa; similar to many e.g. SW:GALU_ECOLI (EMBL:X59940), galU, Escherichia coli UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (301 aa), fasta scores; E(): 0, 50.2% identity in 291 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase; UTP--glucose-1-phosphate uridylyltransferase complement(828738..829607) Neisseria meningitidis Z2491 906836 YP_002342284.1 CDS NMA0849 NC_003116.1 829635 830234 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase complement(829635..830234) Neisseria meningitidis Z2491 906837 YP_002342285.1 CDS NMA0850 NC_003116.1 830227 830460 R NMA0850, len: 77 aa; unknown; hypothetical protein complement(830227..830460) Neisseria meningitidis Z2491 906838 YP_002342286.1 CDS NMA0851 NC_003116.1 830568 831101 R NMA0851, ppa, probable inorganic pyrophosphatase,len: 177 aa; similar to many e.g. SW:IPYR_SULAC (EMBL:X81842), ppa, Sulfolobus acidocaldarius inorganic pyrophosphatase (EC 3.6.1.1) (173 aa), fasta scores; E(): 4.5e-20, 41.0% identity in 166 aa overlap. Contains Pfam match to entry PF00719 Pyrophosphatase, Inorganic pyrophosphatase and PS00387 Inorganic pyrophosphatase signature; inorganic pyrophosphatase complement(830568..831101) Neisseria meningitidis Z2491 906839 YP_002342287.1 CDS ntpA NC_003116.1 831203 831661 R converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase complement(831203..831661) Neisseria meningitidis Z2491 906840 YP_002342288.1 CDS NMA0853 NC_003116.1 832260 833930 D NMA0853, mafB3, probable adhesin, len: 556 aa; similar, except at the C-terminus, to TR:AAD31039 (EMBL:AF142582), mafB, Neisseria gonorrhoeae adhesin (509 aa), E(): 9.1e-28, 32.0% identity in 425 aa overlap. Also similar to NMA2113, fasta scores; E(): 0, 38.6% identity in 412 aa overlap and NMA0324, fasta scores; (): 1.2e-27,33.5% identity in 376 aa overlap, differing from both at the C-terminus. Contains a probable N-terminal signal sequence; adhesin 832260..833930 Neisseria meningitidis Z2491 906841 YP_002342289.1 CDS NMA0854 NC_003116.1 833927 834169 D NMA0854, len: 80 aa; unknown, within a region of unusually low GC content; hypothetical protein 833927..834169 Neisseria meningitidis Z2491 906842 YP_002342290.1 CDS NMA0855 NC_003116.1 834247 834492 D NMA0855, len: 81 aa; unknown, within a region of unusually low GC content; hypothetical protein 834247..834492 Neisseria meningitidis Z2491 906843 YP_002342291.1 CDS NMA0856 NC_003116.1 834495 834884 D NMA0856, len: 129 aa; unknown, similar to NMA0857,fasta scores; E(): 2.7e-34, 62.8% identity in 129 aa overlap and NMA0858, fasta scores; E(): 0, 67.4% identity in 129 aa overlap. Within a region of unusually low GC content; hypothetical protein 834495..834884 Neisseria meningitidis Z2491 906844 YP_002342292.1 CDS NMA0857 NC_003116.1 835000 835449 D NMA0857, len: 149 aa; unknown, similar to NMA0856,fasta scores; E(): 8e-34, 62.8% identity in 129 aa overlap and NMA0858, fasta scores; E(): 9.9e-32, 61.2% identity in 129 aa overlap. Within a region of unusually low GC content; hypothetical protein 835000..835449 Neisseria meningitidis Z2491 906845 YP_002342293.1 CDS NMA0858 NC_003116.1 835597 835986 D NMA0858, len: 129 aa; unknown, similar to NMA0856,fasta scores; E(): 0, 67.4% identity in 129 aa overlap and NMA0857, fasta scores; E(): 1.7e-31, 61.2% identity in 129 aa overlap. Within a region of unusually low GC content; hypothetical protein 835597..835986 Neisseria meningitidis Z2491 906846 YP_002342294.1 CDS NMA0859 NC_003116.1 836027 837484 R NMA0859, probable transmembrane potassium transporter, len: 485 aa; similar to many e.g. SW:TRKH_ECOLI (EMBL:M87049), trkH, Escherichia coli TRK system potassium uptake protein (483 aa), fasta scores; E(): 0, 41.8% identity in 486 aa overlap. Contains hydrophobic, probable membrane-spanning regions; transmembrane potassium transporter complement(836027..837484) Neisseria meningitidis Z2491 906847 YP_002342295.1 CDS apaH NC_003116.1 837499 838329 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(837499..838329) Neisseria meningitidis Z2491 906848 YP_002342296.1 CDS NMA0861 NC_003116.1 838407 838796 R NMA0861, len: 129 aa; unknown, similar to many hypothetical proteins e.g. SW:YVN1_AZOVI (EMBL:M26752) Azotobacter vinelandii hypothetical protein (127 aa),fasta scores; E(): 2e-29, 66.9% identity in 127 aa overlap. Contains Pfam match to entry PF01042 DUF10,Domain of unknown function and PS01094 Hypothetical YER057c/yjjV family signature; hypothetical protein complement(838407..838796) Neisseria meningitidis Z2491 906849 YP_002342297.1 CDS NMA0862 NC_003116.1 838932 839456 R NMA0862, nspA, outer membrane protein, len: 174 aa; highly similar to surface antigens from other Neisseria meningitidis isolates e.g. TR:P96943 (EMBL:U52066) Neisseria meningitidis strain 608B outer membrane protein precursor (174 aa), fasta scores; E(): 0, 98.3% identity in 174 aa overlap. Contains an N-terminal signal sequence. Similar to NMA1890, NMA2043 and NMA1676, which contain short indels with respect to nspA; outer membrane protein complement(838932..839456) Neisseria meningitidis Z2491 906850 YP_002342298.1 CDS NMA0864 NC_003116.1 840042 841241 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(840042..841241) Neisseria meningitidis Z2491 906851 YP_002342299.1 CDS NMA0865 NC_003116.1 841274 843799 R NMA0865, ligA, probable DNA ligase, len: 841 aa; similar to many e.g. SW:DNLJ_RHOMR (EMBL:U10483), ligA,Rhodothermus marinus DNA ligase (EC 6.5.1.2) (712 aa),fasta scores; E(): 0, 40.2% identity in 826 aa overlap. Contains Pfam matches to entry PF01653 DNA_ligase_N,NAD-dependent DNA ligase and to entry PF00533 BRCT, BRCA1 C Terminus (BRCT) domain. Contains PS01056 NAD-dependent DNA ligase signature 2 and PS00017 ATP/GTP-binding site motif A (P-loop); DNA ligase complement(841274..843799) Neisseria meningitidis Z2491 906852 YP_002342300.1 CDS NMA0866 NC_003116.1 843947 845233 R NMA0866, len: 428 aa; unknown, N-terminus is hydrophobic, contains a PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein complement(843947..845233) Neisseria meningitidis Z2491 906853 YP_002342301.1 CDS ampD NC_003116.1 845427 845999 R NMA0867, ampD, probable anhydro-N-acetylmuramyl-tripeptide amidase, len: 190 aa; similar to many e.g. TR:Q46960 (EMBL:U40806), ampD,Enterobacter cloacae anhydro-N-acetylmuramyl-tripeptide amidase (187 aa), fasta scores; E(): 0, 52.9% identity in 172 aa overlap; N-acetyl-anhydromuranmyl-L-alanine amidase complement(845427..845999) Neisseria meningitidis Z2491 906854 YP_002342302.1 CDS NMA0868 NC_003116.1 846083 847078 D NMA0868, periplasmic protein, len: 331 aa; unknown, similar to many hypothetical proteins e.g. SW:YCEG_HAEIN (EMBL:U32728) Haemophilus influenzae hypothetical protein (347 aa), fasta scores; E(): 0, 44.2% identity in 260 aa overlap. Contains N-terminal signal sequence; hypothetical protein 846083..847078 Neisseria meningitidis Z2491 906855 YP_002342303.1 CDS tmk NC_003116.1 847138 847758 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 847138..847758 Neisseria meningitidis Z2491 906856 YP_002342304.1 CDS NMA0870 NC_003116.1 847980 849260 D NMA0870, maeA, probable malate oxidoreductase, len: 426 aa; similar to many e.g. SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus malate oxidoreductase (EC 1.1.1.38) (478 aa), fasta scores; E(): 0, 46.8% identity in 410 aa overlap. Contains PS00331 Malic enzymes signature; malate oxidoreductase 847980..849260 Neisseria meningitidis Z2491 906857 YP_002342305.1 CDS lpxK NC_003116.1 849807 850841 D transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 849807..850841 Neisseria meningitidis Z2491 906859 YP_002342306.1 CDS NMA0873 NC_003116.1 851041 851628 D NMA0873, periplasmic protein, len: 195 aa; unknown, contains probable N-terminal signal sequence; hypothetical protein 851041..851628 Neisseria meningitidis Z2491 906860 YP_002342307.1 CDS NMA0874 NC_003116.1 851697 851879 D NMA0874, len: 60 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:BAA35663 (EMBL:D90730) Escherichia coli hypothetical protein (60 aa), fasta scores; E(): 1.3e-10, 48.3% identity in 60 aa overlap; hypothetical protein 851697..851879 Neisseria meningitidis Z2491 906861 YP_002342308.1 CDS kdsB NC_003116.1 851876 852637 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 851876..852637 Neisseria meningitidis Z2491 906862 YP_002342309.1 CDS NMA0876 NC_003116.1 852660 853061 D NMA0876, len: 133 aa; unknown, C-terminus contains a Neisseria meningitidis repeat, suggesting that the original C-terminus may have been removed by a recombination event; hypothetical protein 852660..853061 Neisseria meningitidis Z2491 906863 YP_002342310.1 CDS NMA0877 NC_003116.1 853115 853279 D NMA0877, len: 54 aa; unknown; hypothetical protein 853115..853279 Neisseria meningitidis Z2491 906864 YP_002342311.1 CDS NMA0878 NC_003116.1 853257 853373 D NMA0878, len: 38 aa; unknown; hypothetical protein 853257..853373 Neisseria meningitidis Z2491 906865 YP_002342312.1 CDS trpA NC_003116.1 853953 854738 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 853953..854738 Neisseria meningitidis Z2491 906866 YP_002342313.1 CDS accD NC_003116.1 854775 855647 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 854775..855647 Neisseria meningitidis Z2491 906867 YP_002342314.1 CDS NMA0881 NC_003116.1 855707 856318 R NMA0881, cnp1, periplasmic protein, len: 203 aa; highly similar to TR:Q50984 (EMBL:M84111), cnp1,Neisseria gonorrhoeae cryptic protein precursor (203 aa),fasta scores; E(): 0, 92.1% identity in 203 aa overlap. Reported to be found in pathogenic Neisseria gonorrhoeae and Neisseria meningitidis species, but not in commensal species. Contains probable N-terminal signal sequence; hypothetical protein complement(855707..856318) Neisseria meningitidis Z2491 906868 YP_002342315.1 CDS NMA0882 NC_003116.1 856427 856651 D NMA0882, len: 74 aa; unknown, similar to hypothetical proteins e.g. SW:YRKI_BACSU (EMBL:D84432) Bacillus subtilis hypothetical protein (75 aa), fasta scores; E(): 6.6e-09, 38.0% identity in 71 aa overlap. Contains Pfam match to entry PF01206 UPF0033,Uncharacterized protein family UPF0033 and PS01148 Uncharacterized protein family UPF0033 signature; hypothetical protein 856427..856651 Neisseria meningitidis Z2491 906869 YP_002342316.1 CDS NMA0883 NC_003116.1 856664 857257 D NMA0883, lipoprotein, len: 197 aa; unknown, contains probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 856664..857257 Neisseria meningitidis Z2491 906870 YP_002342317.1 CDS pyrC NC_003116.1 857317 858351 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 857317..858351 Neisseria meningitidis Z2491 906871 YP_002342318.1 CDS nusB NC_003116.1 858717 859142 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(858717..859142) Neisseria meningitidis Z2491 906872 YP_002342319.1 CDS ribH NC_003116.1 859220 859696 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(859220..859696) Neisseria meningitidis Z2491 906873 YP_002342320.1 CDS NMA0887 NC_003116.1 859743 860066 R NMA0887, len: 107 aa; unknown; hypothetical protein complement(859743..860066) Neisseria meningitidis Z2491 906874 YP_002342321.1 CDS rnc NC_003116.1 860233 860952 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 860233..860952 Neisseria meningitidis Z2491 906875 YP_002342322.1 CDS era NC_003116.1 860999 861922 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 860999..861922 Neisseria meningitidis Z2491 906876 YP_002342323.1 CDS trpF NC_003116.1 863413 864039 R catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase complement(863413..864039) Neisseria meningitidis Z2491 906877 YP_002342324.1 CDS greB NC_003116.1 864098 864589 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB complement(864098..864589) Neisseria meningitidis Z2491 906878 YP_002342325.1 CDS purF NC_003116.1 864689 866233 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(864689..866233) Neisseria meningitidis Z2491 906879 YP_002342326.1 CDS NMA0894 NC_003116.1 866442 866939 R NMA0894, membrane protein, len: 165 aa; similar to SW:CVPA_ECOL (EMBL:J01666), cvpA, Escherichia coli colicin V production protein (162 aa), fasta scores; E(): 4.7e-10, 31.2% identity in 138 aa overlap. Contains hydrophobic, membrane-spanning regions; hypothetical protein complement(866442..866939) Neisseria meningitidis Z2491 906880 YP_002342327.1 CDS NMA0895 NC_003116.1 866932 867930 R NMA0895, tpc, tetrapac protein homologue, len: 332 aa; highly similar to TR:Q50991 (EMBL:Z68205), tpc,Neisseria gonorrhoeae tetrapac forming protein involved in natural transformation competence, epithelial cell invasion and cell separation (346 aa), fasta scores; E(): 0, 89.9% identity in 346 aa overlap. Contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; tetrapac protein complement(866932..867930) Neisseria meningitidis Z2491 906881 YP_002342328.1 CDS NMA0896 NC_003116.1 867943 869217 R NMA0896, folC, bifunctional folylpolyglutamate synthase/dihydrofolate synthase, len: 424 aa; highly similar to many e.g. TR:Q50990 (EMBL:Z68205), folC,Neisseria gonorrhoeae bifunctional folylpolyglutamate synthase/dihydrofolate synthase (EC 6.3.2.17) (EC 6.3.2.12) (424 aa), fasta scores; E(): 0, 93.4% identity in 424 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family; bifunctional folylpolyglutamate synthase/dihydrofolate synthase complement(867943..869217) Neisseria meningitidis Z2491 906882 YP_002342329.1 CDS NMA0897 NC_003116.1 869249 869689 R NMA0897, folI, transcriptional regulator,len: 146 aa; highly similar to TR:Q50989 (EMBL:Z68205),folI, Neisseria gonorrhoeae transcriptional activator (146 aa), fasta scores; E(): 0, 95.8% identity in 144 aa overlap. Note that activation of folC expression by folI provided in trans has only been demonstrated in Escherichia coli; transcriptional regulator complement(869249..869689) Neisseria meningitidis Z2491 906883 YP_002342330.1 CDS NMA0899 NC_003116.1 869694 870068 R NMA0899, len: 124 aa; unknown; hypothetical protein complement(869694..870068) Neisseria meningitidis Z2491 906884 YP_002342331.1 CDS NMA0900 NC_003116.1 870126 870854 R NMA0900, amino acid permease ATP-binding protein, len: 242 aa; similar to many e.g. SW:GLNQ_BACST (EMBL:M61017), glnQ, Bacillus stearothermophilus glutamine transport ATP-binding protein (242 aa), fasta scores; E(): 0, 63.2% identity in 242 aa overlap and SW:AAPP_RHILV (EMBL:X82596), aapP, Rhizobium leguminosarum general L-amino acid transport ATP-binding protein (257 aa), fasta scores; E(): 0, 56.9% identity in 239 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter,PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); amino acid permease ATP-binding protein complement(870126..870854) Neisseria meningitidis Z2491 906885 YP_002342332.1 CDS ksgA NC_003116.1 871027 871806 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(871027..871806) Neisseria meningitidis Z2491 906886 YP_002342333.1 CDS NMA0903 NC_003116.1 871997 872692 D NMA0903, len: 231 aa; unknown; hypothetical protein 871997..872692 Neisseria meningitidis Z2491 906887 YP_002342334.1 CDS trpB NC_003116.1 872877 874079 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 872877..874079 Neisseria meningitidis Z2491 906888 YP_002342335.1 CDS NMA0905 NC_003116.1 874258 879579 R NMA0905, iga, IgA1 protease, len: 1773 aa; highly similar to IgA1 proteases from Neisseria and Haemophilus species e.g. TR:Q51169 (EMBL:X82474), iga, Neisseria meningitidis HF13 IgA1 protease (1561 aa), fasta scores; E(): 0, 77.9% identity in 1784 aa overlap. Also similar to NMA0457, iga2 (29.9% identity in 1339 aa overlap); IgA1 protease complement(874258..879579) Neisseria meningitidis Z2491 906889 YP_002342336.1 CDS NMA0906 NC_003116.1 881651 883726 D NMA0906, comA, competence protein, len: 691 aa; highly similar to SW:COMA_NEIGO (EMBL:S75490), comA,Neisseria gonorrhoeae competence protein essential for natural transformation (691 aa), fasta scores; E(): 0,95.1% identity in 691 aa overlap. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily. Contains hydrophobic, probable membrane-spanning regions; competence protein 881651..883726 Neisseria meningitidis Z2491 906890 YP_002342337.1 CDS NMA0907 NC_003116.1 883784 884587 R NMA0907, comL, competence lipoprotein, len: 267 aa; highly similar to SW:COML_NEIGO (EMBL:Z49895), comL,Neisseria gonorrhoeae competence lipoprotein (267 aa),fasta scores; E(): 0, 98.5% identity in 267 aa overlap. Contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a probable N-terminal signal sequence; competence lipoprotein complement(883784..884587) Neisseria meningitidis Z2491 906891 YP_002342338.1 CDS NMA0908 NC_003116.1 884586 885710 D NMA0908, rluD, probable ribosomal large subunit pseudouridine synthase D, len: 374 aa; similar to many e.g. SW:RLUD_ECOLI (EMBL:U50134), rluD, Escherichia coli ribosomal large subunit pseudouridine synthase D (EC 4.2.1.70) (326 aa), fasta scores; E(): 0, 49.5% identity in 323 aa overlap. This protein has an N-terminal extension of approx. 20 aa which is not present in otherwise similar proteins. Contains Pfam matches to entry PF01479 S4, S4 domain and to entry PF00849 YABO,Hypothetical yabO/yceC/sfhB family. Contains PS01129 Hypothetical yabO/yceC/sfhB family signature; ribosomal large subunit pseudouridine synthase D 884586..885710 Neisseria meningitidis Z2491 906892 YP_002342339.1 CDS NMA0909 NC_003116.1 885863 886810 R NMA0909, probable transmembrane transport protein,len: 315 aa; similar to many eukaryotic (Na)+ dependent transporters e.g. SW:NTCI_HUMAN (EMBL:U10417), SLC10A2,Homo sapiens ileal sodium/bile acid cotransporter (348 aa), fasta scores; E(): 9.9e-19, 31.4% identity in 287 aa overlap. Also similar to bacterial hypothetical proteins e.g. TR:O34524 (EMBL:AF027868), yocS, Bacillus subtilis transporter (321 aa), fasta scores; E(): 0, 58.1% identity in 313 aa overlap. Similar to NMA0046, fasta scores; E(): 0, 37.4% identity in 310 aa overlap. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein complement(885863..886810) Neisseria meningitidis Z2491 906893 YP_002342340.1 CDS NMA0911 NC_003116.1 887369 888148 D NMA0911, len: 259 aa; unknown, similar to many bacterial hypothetical proteins e.g. SW:YFIH_ECOLI (EMBL:U50134), yfiH, Escherichia coli hypothetical protein (243 aa), fasta scores; E(): 0, 50.4% identity in 240 aa overlap; hypothetical protein 887369..888148 Neisseria meningitidis Z2491 906894 YP_002342341.1 CDS NMA0912 NC_003116.1 888200 888679 D NMA0912, probable lipoprotein, len; 159 aa; similar to SW:RLPB_ECOLI (EMBL:M18277), rlpB, Escherichia coli rare lipoprotein B precursor (193 aa), fasta scores; E(): 1.9e-07, 30.3% identity in 165 aa overlap. Contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a probable N-terminal signal sequence; lipoprotein 888200..888679 Neisseria meningitidis Z2491 906895 YP_002342342.1 CDS holA NC_003116.1 888681 889679 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 888681..889679 Neisseria meningitidis Z2491 906896 YP_002342343.1 CDS NMA0914 NC_003116.1 889800 890219 D NMA0914, membrane protein, len: 139 aa; unknown, contains hydrophobic, membrane-spanning regions; hypothetical protein 889800..890219 Neisseria meningitidis Z2491 906897 YP_002342344.1 CDS NMA0915 NC_003116.1 890297 890809 D NMA0915, len: 170 aa; unknown, contains hydrophobic, membrane-spanning regions; hypothetical protein 890297..890809 Neisseria meningitidis Z2491 906898 YP_002342345.1 CDS NMA0916 NC_003116.1 890893 891777 R NMA0916, len: 294 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YICC_ECOLI (EMBL:L10328),yicC, Escherichia coli hypothetical protein (287 aa),fasta scores; E(): 0, 41.0% identity in 290 aa overlap; hypothetical protein complement(890893..891777) Neisseria meningitidis Z2491 906899 YP_002342346.1 CDS rpoH NC_003116.1 892264 893136 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(892264..893136) Neisseria meningitidis Z2491 906900 YP_002342347.1 CDS lnt NC_003116.1 893391 894929 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(893391..894929) Neisseria meningitidis Z2491 906901 YP_002342348.1 CDS NMA0919 NC_003116.1 894969 895724 R NMA0919, similar to hypothetical proteins from Escherichia coli and Mycobacterium tuberculosis e.g. SW:YEDI_ECOLI (EMBL:AE000287), yedI, Escherichia coli hypothetical protein (305 aa), fasta scores; E(): 7.7e-24,60.5% identity in 114 aa overlap; hypothetical protein complement(894969..895724) Neisseria meningitidis Z2491 906902 YP_002342349.1 CDS NMA0921 NC_003116.1 895920 896201 D NMA0921, similar to hypothetical proteins from Escherichia coli e.g. SW:YCGO_ECOLI (EMBL:AE000217), ycgO,Escherichia coli Na(+)/H(+) exchanger (578 aa),blastp score; Expect = 2.3e-11; hypothetical protein 895920..896201 Neisseria meningitidis Z2491 906903 YP_002342350.1 CDS NMA0924 NC_003116.1 896747 897037 D hypothetical protein 896747..897037 Neisseria meningitidis Z2491 7163864 YP_002342351.1 CDS NMA0925 NC_003116.1 897012 897503 R NMA0925, cytochrome C, len: 163 aa; shows very weak similarity to many e.g. SW:C552_THETH (EMBL:M93437), cycA, Thermus aquaticus cytochrome C-552 precursor (148 aa), fasta scores; E(): 0.00017, 33.6% identity in 137 aa overlap. Contains Pfam match to entry PF00034 cytochrome_c, Cytochrome c and PS00190 Cytochrome c family heme-binding site signature. Contains a probable N-terminal signal sequence; cytochrome C complement(897012..897503) Neisseria meningitidis Z2491 906904 YP_002342352.1 CDS hemH NC_003116.1 897694 898704 R protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase complement(897694..898704) Neisseria meningitidis Z2491 906906 YP_002342353.1 CDS tgt NC_003116.1 898786 899901 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(898786..899901) Neisseria meningitidis Z2491 906907 YP_002342354.1 CDS thrS NC_003116.1 900210 902123 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 900210..902123 Neisseria meningitidis Z2491 906908 YP_002342355.1 CDS infC NC_003116.1 902141 902662 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 902141..902662 Neisseria meningitidis Z2491 906909 YP_002342356.1 CDS rpmI NC_003116.1 902809 903006 D NMA0931, rpmI, probable 50S ribosomal protein L35,len: 65 aa; similar to many e.g. SW:RL35_ECOLI (EMBL:AE000266), rpmI, Escherichia coli 50S ribosomal protein L35 (64 aa), fasta scores; E(): 2.4e-10, 57.8% identity in 64 aa overlap. Contains Pfam match to entry PF01632 Ribosomal_L35p, Ribosomal protein L35 and PS00936 Ribosomal protein L35 signature; 50S ribosomal protein L35 902809..903006 Neisseria meningitidis Z2491 906910 YP_002342357.1 CDS rplT NC_003116.1 903019 903378 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 903019..903378 Neisseria meningitidis Z2491 906911 YP_002342358.1 CDS pheS NC_003116.1 903724 904716 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 903724..904716 Neisseria meningitidis Z2491 906912 YP_002342359.1 CDS NMA0935 NC_003116.1 904893 905957 D NMA0935, len: 354 aa; unknown, lies in a region of unusually low GC content. Similar to NMA0346, fasta scores; E(): 8.4e-19, 28.9% identity in 339 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 904893..905957 Neisseria meningitidis Z2491 906913 YP_002342360.1 CDS NMA0936 NC_003116.1 905964 906482 D NMA0936, len: 172 aa; unknown, lies in a region of unusually low GC content; hypothetical protein 905964..906482 Neisseria meningitidis Z2491 906914 YP_002342361.1 CDS pheT NC_003116.1 906518 908881 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 906518..908881 Neisseria meningitidis Z2491 906915 YP_002342362.1 CDS ihfA NC_003116.1 908955 909257 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 908955..909257 Neisseria meningitidis Z2491 906916 YP_002342363.1 CDS NMA0939 NC_003116.1 909259 909549 D NMA0939, len: 96 aa; unknown; hypothetical protein 909259..909549 Neisseria meningitidis Z2491 906917 YP_002342364.1 CDS fxsA NC_003116.1 909879 910364 D F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 909879..910364 Neisseria meningitidis Z2491 906918 YP_002342365.1 CDS NMA0941 NC_003116.1 910624 910863 D NMA0941, len: 79 aa; unknown; hypothetical protein 910624..910863 Neisseria meningitidis Z2491 906919 YP_002342366.1 CDS NMA0942 NC_003116.1 911076 912377 D NMA0942, bioA, probable adenosylmethionine-8-amino-7-oxononanoate aminotransferase, len: 433 aa; similar to many e.g. SW:BIOA_ECOLI (EMBL:J04423), bioA, Escherichia coli adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (429 aa), fasta scores; E(): 0, 58.4% identity in 418 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 911076..912377 Neisseria meningitidis Z2491 906920 YP_002342367.1 CDS bioD NC_003116.1 912374 913021 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 912374..913021 Neisseria meningitidis Z2491 906921 YP_002342368.1 CDS NMA0944 NC_003116.1 913036 913512 D NMA0944, len: 158 aa, unknown, shows very weak similarity in the C-terminus to SW:UBIC_ECOLI (EMBL:M93136), ubiC, Escherichia coli chorismate--pyruvate lyase (EC 4.-.-.-) (164 aa), fasta scores; E(): 0.0086,34.1% identity in 91 aa overlap; hypothetical protein 913036..913512 Neisseria meningitidis Z2491 906922 YP_002342369.1 CDS ubiA NC_003116.1 913542 914432 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 913542..914432 Neisseria meningitidis Z2491 906923 YP_002342370.1 CDS NMA0946 NC_003116.1 914617 915066 D NMA0946, regulatory protein, len: 149 aa; similar to CDS from several rpoN operons e.g. SW:PTSN_ECOLI (EMBL:U12684), ptsN, Escherichia coli nitrogen regulatory IIA protein (EC 2.7.1.69) (163 aa),fasta scores; E(): 9.4e-17, 42.6% identity in 129 aa overlap, which influences transcription of sigma 54-dependent genes. Contains Pfam match to entry PF00359 PTS_EIIA_2, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 and PS00372 PTS EIIA domains phosphorylation site signature 2; regulatory protein 914617..915066 Neisseria meningitidis Z2491 906924 YP_002342371.1 CDS NMA0947 NC_003116.1 915070 916032 D catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 915070..916032 Neisseria meningitidis Z2491 906925 YP_002342372.1 CDS NMA0948 NC_003116.1 916013 916867 D NMA0948, len: 284 aa; similar to many e.g. TR:Q9ZA87 (EMBL:AF088980) Proteus mirabilis protein (284 aa), fasta scores; E(): 0, 44.0% identity in 282 aa overlap. Proteus mirabilis mutated in this gene exhibit reduced virulence in a mouse model of ascending urinary tract infection. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 916013..916867 Neisseria meningitidis Z2491 906926 YP_002342373.1 CDS rbgA NC_003116.1 916948 917889 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 916948..917889 Neisseria meningitidis Z2491 906927 YP_002342374.1 CDS NMA0951 NC_003116.1 917990 918592 D NMA0951, len: 200 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:O83471 (EMBL:AE001223),TP0458, Treponema pallidum hypothetical protein (192 aa),fasta scores; E(): 4.9e-12, 38.2% identity in 173 aa overlap; hypothetical protein 917990..918592 Neisseria meningitidis Z2491 906928 YP_002342375.1 CDS NMA0952 NC_003116.1 918776 920449 D NMA0952, recN, probable DNA repair protein, len: 557 aa; similar to many e.g. SW:RECN_ECOLI (EMBL:Y00357),recN, Escherichia coli DNA repair protein (553 aa), fasta scores; E():0, 39.1% identity in 553 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); DNA repair protein 918776..920449 Neisseria meningitidis Z2491 906929 YP_002342376.1 CDS NMA0954 NC_003116.1 921567 923186 R NMA0954, len: 539 aa; unknown, similar to parts of bacterial hypothetical proteins e.g. TR:P77182 (EMBL:AE000321) Escherichia coli hypothetical protein (688 aa), fasta scores; E(): 1.7e-28, 26.8% identity in 477 aa overlap; hypothetical protein complement(921567..923186) Neisseria meningitidis Z2491 906931 YP_002342377.1 CDS NMA0955 NC_003116.1 923282 923674 D NMA0955, len: 130 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:Q51512 (EMBL:X66592) Pseudomonas aeruginosa hypothetical protein (123 aa),fasta scores; E(): 5.6e-22, 56.3% identity in 112 aa overlap; hypothetical protein 923282..923674 Neisseria meningitidis Z2491 906932 YP_002342378.1 CDS ubiE NC_003116.1 923717 924454 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 923717..924454 Neisseria meningitidis Z2491 906933 YP_002342379.1 CDS NMA0957 NC_003116.1 924674 925153 D NMA0957, len: 159 aa; unknown; hypothetical protein 924674..925153 Neisseria meningitidis Z2491 906934 YP_002342380.1 CDS NMA0958 NC_003116.1 925280 925774 R NMA0958, folK, probable 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine- pyrophosphokinase, len: 164 aa; similar to many e.g. SW:HPPK_ECOLI (EMBL:L06495), folK, Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (158 aa), fasta scores; E(): 1.2e-15, 43.0% identity in 135 aa overlap. Contains fam match to entry PF01288 HPPK,7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase (HPPK); 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine- pyrophosphokinase complement(925280..925774) Neisseria meningitidis Z2491 906935 YP_002342381.1 CDS NMA0959 NC_003116.1 925784 926158 R NMA0959, regulator, len: 124 aa; similar to TR:AAD32201 (EMBL:AF134855), sirB ORF1, Salmonella typhimurium protein affecting expression of a type III secretion system within Salmonella pathogenicity island 1 (129 aa), fasta scores; E(): 3.3e-06, 31.9% identity in 119 aa overlap and TR:Q46755 (EMBL:U18555) Escherichia coli hypothetical protein within kdsA operon (130 aa),fasta scores; E(): 1.3e-06, 29.3% identity in 116 aa overlap; regulator complement(925784..926158) Neisseria meningitidis Z2491 906936 YP_002342382.1 CDS NMA0960 NC_003116.1 926212 926778 R NMA0960, len: 188 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:O34614 (EMBL:AF008220),ytqB, Bacillus subtilis hypothetical protein (194 aa),fasta scores; E(): 3.1e-28, 41.4% identity in 191 aa overlap; hypothetical protein complement(926212..926778) Neisseria meningitidis Z2491 906937 YP_002342383.1 CDS NMA0961 NC_003116.1 926863 927156 R NMA0961, hfq, probable regulator, len: 97 aa; similar to many e.g. TR:Q56928 (EMBL:D28762), ymr,Yersinia enterocolitica positive regulator of expression of heat-stable enterotoxin gene (101 aa), fasta scores; E(): 3.3e-20, 65.6% identity in 96 aa overlap, TR:AAD38187 (EMBL:AF154075), hfq, Brucella abortus host factor I protein which is a major determinant of virulence in mice (78 aa), fasta scores; E(): 2.4e-11, 51.4% identity in 72 aa overlap and SW:HFQ_ECOLI (EMBL:D00743), hfq,Escherichia coli host factor-I protein for bacteriophage Q beta (101 aa), fasta scores; E(): 1e-19, 63.0% identity in 100 aa overlap; regulator complement(926863..927156) Neisseria meningitidis Z2491 906938 YP_002342384.1 CDS NMA0962 NC_003116.1 927285 928223 R NMA0962, probable D-alanyl-D-alanine-endopeptidase,len: 312 aa; similar to many penicillin-binding proteins e.g. TR:AF156692 (EMBL:AF156692), pbp4, Neisseria gonorrhoeae penicillin-binding protein 4 (312 aa), fasta scores; E(): 0, 98.1% identity in 312 aa overlap and SW:PBP5_PSEAE (EMBL:U62582), pbpG, Pseudomonas aeruginosa penicillin-binding protein 5 precursor (EC 3.4.-.-) (311 aa), fasta scores; E(): 0, 43.8% identity in 240 aa overlap. Similar to part of NMA1095, fasta scores; E(): 1.2e-13, 29.6% identity in 243 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine-endopeptidase complement(927285..928223) Neisseria meningitidis Z2491 906939 YP_002342385.1 CDS NMA0963 NC_003116.1 928481 928984 D NMA0963, len: 167 aa; unknown, similar to many bacterial proteins of unknown function e.g. TR:P72697 (EMBL:D90900), bcp, Synechocystis sp. bacterioferritin comigratory protein (160 aa), fasta scores; E(): 4.3e-22,45.1% identity in 142 aa overlap. Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family; hypothetical protein 928481..928984 Neisseria meningitidis Z2491 906940 YP_002342386.1 CDS NMA0964 NC_003116.1 929036 929911 D NMA0964, xerD, probable integrase/recombinase, len: 291 aa; similar to many e.g. SW:XERD_ECOLI (EMBL:M54884),xerD, Escherichia coli integrase/recombinase (298 aa),fasta scores; E(): 0, 48.6% identity in 290 aa overlap. Contains Pfam match to entry PF00589 Phage_integrase,'Phage' integrase family. Similar to NMA0588, fasta scores; E(): 2.9e-30, 35.0% identity in 294 aa overlap; integrase/recombinase 929036..929911 Neisseria meningitidis Z2491 906941 YP_002342387.1 CDS NMA0965 NC_003116.1 930083 930283 D NMA0965, probable ferredoxin, len: 66 aa; similar to many e.g. SW:BFD_ECOLI (EMBL:M27176), bfd, Escherichia coli bacterioferritin-associated ferredoxin (64 aa), fasta scores; E(): 0.47, 28.6% identity in 42 aa overlap; ferredoxin 930083..930283 Neisseria meningitidis Z2491 906942 YP_002342388.1 CDS NMA0966 NC_003116.1 930449 930682 D NMA0966, thioredoxin, len: 77 aa; shows weak similarity to many e.g. TR:CAB40815 (EMBL:AJ133006),trxA, Listeria monocytogenes thioredoxin (EC 1.8.1.9) (103 aa), fasta scores; E(): 0.41, 33.8% identity in 65 aa overlap and SW:YV35_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis hypothetical protein (97 aa), fasta scores; E(): 4e-05, 29.8% identity in 84 aa overlap. Contains PS00190 Cytochrome c family heme-binding site signature; thioredoxin 930449..930682 Neisseria meningitidis Z2491 906943 YP_002342389.1 CDS NMA0967 NC_003116.1 931156 932019 R NMA0967, rfbD, probable dTDP-4-dehydrorhamnose reductase, len: 287 aa; similar to many e.g. SW:RFBD_SALTY (EMBL:X56793), rfbD, Salmonella typhimurium dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) (299 aa),fasta scores; E(): 0, 39.0% identity in 295 aa overlap; dTDP-4-dehydrorhamnose reductase complement(931156..932019) Neisseria meningitidis Z2491 906944 YP_002342390.1 CDS hemH NC_003116.1 932217 933080 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 932217..933080 Neisseria meningitidis Z2491 906945 YP_002342391.1 CDS pnp NC_003116.1 933317 935437 D NMA0969, pnp, probable polyribonucleotide nucleotidyltransferase, len: 706 aa; similar to many e.g. SW:PNP_PHOLU (EMBL:X76069), pnp, Photorhabdus luminescens polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (709 aa), fasta scores; E(): 0, 63.7% identity in 703 aa overlap. Contains two Pfam matches to entry PF01138 RNase_PH, 3' exoribonuclease family, Pfam match to entry PF00013 KH-domain, KH domain and Pfam match to entry PF00575 S1, S1 RNA binding domain; polynucleotide phosphorylase 933317..935437 Neisseria meningitidis Z2491 906946 YP_002342392.1 CDS NMA0970 NC_003116.1 935510 936178 R NMA0970, len: 222 aa; unknown; hypothetical protein complement(935510..936178) Neisseria meningitidis Z2491 906947 YP_002342393.1 CDS NMA0971 NC_003116.1 936192 936488 R NMA0971, lipoprotein, len: 98 aa; unknown,contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein complement(936192..936488) Neisseria meningitidis Z2491 906948 YP_002342394.1 CDS dapF NC_003116.1 936625 937476 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 936625..937476 Neisseria meningitidis Z2491 906949 YP_002342395.1 CDS NMA0973 NC_003116.1 937473 938078 D NMA0973, probable integral membrane protein, len: 201 aa; unknown. Contains hydrophobic, probable membrane-spanning regions; integral membrane protein 937473..938078 Neisseria meningitidis Z2491 906950 YP_002342396.1 CDS NMA0974 NC_003116.1 938272 939204 D NMA0974, cysK, probable cysteine synthase, len: 310 aa; similar to many from bacteria and eukaryotes e.g. SW:CYSK_SPIOL (EMBL:D10476), cysK, Spinacia oleracea cysteine synthase (EC 2.5.1.47) (325 aa), fasta scores; E(): 0, 58.1% identity in 310 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase,Pyridoxal-phosphate dependent enzymes and PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site; cysteine synthase 938272..939204 Neisseria meningitidis Z2491 906951 YP_002342397.1 CDS NMA0975 NC_003116.1 939791 940669 D NMA0975, probable integral membrane protein, len: 292 aa; unknown, shows weak similarity to bacterial hypothetical proteins e.g. SW:YDED_ECOLI (EMBL:AE000250),ydeD, Escherichia coli hypothetical protein (266 aa),fasta scores; E(): 1.4e-07, 27.8% identity in 255 aa overlap. Contains hydrophobic, probable membrane-spanning regions; integral membrane protein 939791..940669 Neisseria meningitidis Z2491 906952 YP_002342398.1 CDS NMA0976 NC_003116.1 940934 941953 R NMA0976, lepB, probable signal peptidase I, len: 292 aa; similar to many e.g. SW:LEP_ECOLI (EMBL:K00426),lepB, Escherichia coli signal peptidase I (EC 3.4.21.89) (324 aa), fasta scores; E(): 1.5e-27, 40.9% identity in 257 aa overlap. The N-terminus differs from its homologues. A start codon chosen with reference to the N-terminal membrane-spanning regions found in characterised signal peptidases. Contains two Pfam match to entry PF00461 Peptidase_S26, Signal peptidase I,PS00760 Signal peptidases I lysine active site and PS00761 Signal peptidases I signature 3; signal peptidase I complement(940934..941953) Neisseria meningitidis Z2491 906953 YP_002342399.1 CDS lepA NC_003116.1 942096 943889 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(942096..943889) Neisseria meningitidis Z2491 906954 YP_002342400.1 CDS NMA0978 NC_003116.1 944034 944735 R NMA0978, pfs, probable 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, len: 233 aa; similar to many e.g. SW:PFS_ECOLI (EMBL:U24438), pfs, Escherichia coli MTA/SAH nucleosidase (EC 3.2.2.16) (EC 3.2.2.9) (232 aa), fasta scores; E(): 0, 47.8% identity in 228 aa overlap. Contains Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase family; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(944034..944735) Neisseria meningitidis Z2491 906955 YP_002342401.1 CDS NMA0979 NC_003116.1 944921 946033 D NMA0979, pilT2, pilus retraction protein,len: 370 aa; similar to many e.g. SW:PILT_PSEAE (EMBL:M55524), pilT, Pseudomonas aeruginosa twitching mobility protein which complements mutants deficient in this function (344 aa), fasta scores; E(): 0, 43.8% identity in 329 aa overlap. Similar to TR:O85741 (EMBL:AF074716), pilT, from Neisseria meningitidis (strain 8013) (347 aa), fasta scores; E(): 0, 40.9% identity in 335 aa overlap. Shows weaker similarity to bacterial type II secretion proteins e.g. SW:GSPE_KLEPN (EMBL:M32613),pulE, Klebsiella pneumoniae general secretion pathway protein (497 aa), fasta scores; E(): 5.6e-14, 33.1% identity in 281 aa overlap. Also similar to NMA0218, fasta scores; E(): 0, 40.1% identity in 334 aa overlap and NMA0219, fasta scores; E(): 0, 44.8% identity in 348 aa overlap. Contains Pfam match to entry PF00437 GSPII_E,Bacterial type II secretion system protein, PS00662 Bacterial type II secretion system protein E signature and PS00017 ATP/GTP-binding site motif A (P-loop). Also similar to pilT NMA0218 (40.1% identity in 334 aa overlap), and pilU NMA0219 (44.8% identity in 348 aa overlap); pilus retraction protein 944921..946033 Neisseria meningitidis Z2491 906956 YP_002342402.1 CDS holB NC_003116.1 946067 947044 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 946067..947044 Neisseria meningitidis Z2491 906957 YP_002342403.1 CDS NMA0981 NC_003116.1 947048 947398 D NMA0981, pilus biogenesis protein, len: 116 aa; similar to TR:Q51538 (EMBL:L42622), pilZ,Pseudomonas aeruginosa protein involved in biogenesis of type 4 fimbriae (118 aa), fasta scores; E(): 9.9e-12,31.5% identity in 108 aa overlap; pilus biogenesis protein 947048..947398 Neisseria meningitidis Z2491 906958 YP_002342404.1 CDS NMA0982 NC_003116.1 947403 948182 D NMA0982, len: 259 aa; unknown, similar to many hypothetical proteins e.g. SW:YCFH_ECOLI (EMBL:AE000210),ycfH, Escherichia coli hypothetical protein (265 aa),fasta scores; E(): 0, 44.7% identity in 255 aa overlap. Contains Pfam match to entry PF01026 UPF0006,Uncharacterized protein family and PS01137 Uncharacterized protein family UPF0006 signature 1; hypothetical protein 947403..948182 Neisseria meningitidis Z2491 906959 YP_002342405.1 CDS NMA0984 NC_003116.1 948538 948849 D NMA0984, len: 103 aa; unknown, similar to many hypothetical proteins, some of which are glutaredoxin-like e.g. SW:YI46_SYNY3 (EMBL:D90903) Synechocystis sp. hypothetical protein (107 aa), fasta scores; E(): 7.4e-24,62.5% identity in 96 aa overlap. No N-terminal CXXC active site residues are apparent in this CDS; hypothetical protein 948538..948849 Neisseria meningitidis Z2491 906961 YP_002342406.1 CDS upp NC_003116.1 948955 949581 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 948955..949581 Neisseria meningitidis Z2491 906962 YP_002342407.1 CDS NMA0986 NC_003116.1 949604 949924 D NMA0986, len: 106 aa; unknown; hypothetical protein 949604..949924 Neisseria meningitidis Z2491 906963 YP_002342408.1 CDS NMA0987 NC_003116.1 950175 950597 D NMA0987, probable secreted protein, len: 140 aa; unknown, highly similar to TR:O30392 (EMBL:AF003941),gly1ORF1, Neisseria gonorrhoeae PilA-regulated protein (140 aa), fasta scores; E(): 0, 97.9% identity in 140 aa overlap. Found in outer membrane preparations of wild-type N. gonorrhoeae. A knockout of the gly1 locus results in increased toxicity of the strain to human fallopian tube organ cultures. Contains an N-terminal signal sequence; secreted protein 950175..950597 Neisseria meningitidis Z2491 906964 YP_002342409.1 CDS hemD NC_003116.1 950636 951376 D catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 950636..951376 Neisseria meningitidis Z2491 906965 YP_002342410.1 CDS NMA0989 NC_003116.1 951451 952725 D NMA0989, len: 424 aa; unknown, shows weak similarity to uroporphyrin-III C-methyltransferase from Escherichia coli and Haemophilus influenzae, e.g. SW:HEMX_ECOLI (EMBL:X13406), hemX,Escherichia coli uroporphyrin-III C-methyltransferase (EC 2.1.1.107) (393 aa), fasta scores; E(): 8.1e-17, 25.4% identity in 389 aa overlap; hypothetical protein 951451..952725 Neisseria meningitidis Z2491 906966 YP_002342411.1 CDS NMA0990 NC_003116.1 952722 953939 D NMA0990, len: 405 aa; unknown; hypothetical protein 952722..953939 Neisseria meningitidis Z2491 906967 YP_002342412.1 CDS hemE NC_003116.1 954014 955078 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 954014..955078 Neisseria meningitidis Z2491 906968 YP_002342413.1 CDS radA NC_003116.1 955264 956643 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 955264..956643 Neisseria meningitidis Z2491 906969 YP_002342414.1 CDS NMA0993 NC_003116.1 956919 957398 R NMA0993, periplasmic protein, len: 159 aa; unknown, similar to TR:O83865 (EMBL:AE001259) Treponema pallidum hypothetical protein (168 aa), fasta scores; E(): 2.1e-16, 35.9% identity in 153 aa overlap. Contains a N-terminal signal sequence; hypothetical protein complement(956919..957398) Neisseria meningitidis Z2491 906970 YP_002342415.1 CDS NMA0994 NC_003116.1 957530 957889 R NMA0994, periplasmic protein, len: 119 aa; unknown, shows weak similarity to SW:PSPE_ECOLI (EMBL:X57560), pspE, Escherichia coli phage shock protein (104 aa), fasta scores; E(): 1.9e-09, 40.9% identity in 88 aa overlap. Contains Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain. Contains a N-terminal signal sequence; hypothetical protein complement(957530..957889) Neisseria meningitidis Z2491 906971 YP_002342416.1 CDS NMA0995 NC_003116.1 957928 961542 R NMA0995, recB, probable exodeoxyribonuclease V beta chain, len: 1204 aa; similar to bacterial deoxyribonucleases e.g. SW:EX5B_ECOLI (EMBL:X04581), recB,Escherichia coli exodeoxyribonuclease V beta chain (EC 3.1.11.5) (1180 aa),fasta scores; E(): 0, 32.2% identity in 1241 aa overlap. Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase and two PS00017 ATP/GTP-binding site motif A (P-loop); exodeoxyribonuclease V subunit beta complement(957928..961542) Neisseria meningitidis Z2491 906972 YP_002342417.1 CDS NMA0996 NC_003116.1 961775 962683 R NMA0996, len: 302 aa; unknown, similar to TR:P76536 (EMBL:AE000330) Escherichia coli hypothetical protein (308 aa), fasta scores; E(): 0, 49.7% identity in 302 aa overlap and TR:O07180 (EMBL:Z96797) Mycobacterium tuberculosis hypothetical protein (335 aa), fasta scores; E(): 5.3e-33, 34.5% identity in 304 aa overlap; hypothetical protein complement(961775..962683) Neisseria meningitidis Z2491 906973 YP_002342418.1 CDS NMA0997 NC_003116.1 962968 963795 D NMA0997, probable amino acid permease substrate-binding protein, len: 275 aa; similar to many e.g. SW:HISJ_ECOLI (EMBL:U47027), hisJ, Escherichia coli histidine-binding periplasmic protein precursor (260 aa),fasta scores; E(): 5.2e-13, 27.6% identity in 232 aa overlap. Similar to many hypothetical binding proteins e.g. TR:Q9ZKR0 (EMBL:AE001517) Helicobacter pylori J99 amino acid abc transporter, binding protein precursor (257 aa), fasta scores; E(): 0, 54.4% identity in 237 aa overlap. Contains Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, PS01039 Bacterial extracellular solute-binding proteins, family 3 signature and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; amino acid permease 962968..963795 Neisseria meningitidis Z2491 906974 YP_002342419.1 CDS NMA0999 NC_003116.1 963785 964501 D NMA0999, probable amino acid permease integral membrane protein, len: 238 aa; similar to many e.g. SW:GLNP_ECOLI (EMBL:X14180), glnP, Escherichia coli glutamine transport system permease (219 aa),fasta scores; E(): 1.2e-20, 34.0% identity in 209 aa overlap. Similar to many hypothetical permease integral membrane proteins e.g. TR:Q9ZKR1 (EMBL:AE001517) Helicobacter pylori J99 amino acid abc transporter, permease (237 aa), fasta scores; E(): 0, 58.4% identity in 226 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains hydrophobic, probable membrane-spanning regions; amino acid permease integral membrane protein 963785..964501 Neisseria meningitidis Z2491 906975 YP_002342420.1 CDS NMA1000 NC_003116.1 964511 965266 D NMA1000, probable amino acid permease ATP-binding protein, len: 251 aa; similar to many e.g. SW:GLNQ_BACST (EMBL:M61017), glnQ, Bacillus stearothermophilus glutamine transport ATP-binding protein (242 aa), E(): 0, 52.6% identity in 247 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); amino acid permease ATP-binding protein 964511..965266 Neisseria meningitidis Z2491 906976 YP_002342421.1 CDS NMA1001 NC_003116.1 965286 966668 R NMA1001, pgm, phosphoglucomutase, len: 460 aa; highly similar to SW:PGMU_NEIME (EMBL:U02490), pgm,Neisseria meningitidis strain NMB phosphoglucomutase (EC 5.4.2.2) (460 aa), fasta scores; E(): 0, 94.3% identity in 460 aa overlap. Contains Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase and PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature; phosphoglucomutase complement(965286..966668) Neisseria meningitidis Z2491 906977 YP_002342422.1 CDS NMA1002 NC_003116.1 966831 967340 R NMA1002, ppiB, probable peptidyl-prolyl cis-trans isomerase B, len: 169 aa; similar to many e.g. SW:CYPB_ECOLI (EMBL:M55430), ppiB, Escherichia coli peptidyl-prolyl cis-trans isomerase B (EC 5.2.1.8) (164 aa), fasta scores; E(): 0, 58.9% identity in 163 aa overlap. Also similar to NMA1469, fasta scores; E(): 2.3e-21, 46.3% identity in 162 aa overlap. Contains Pfam match to entry PF00160 pro_isomerase, Peptidyl-prolyl cis-trans isomerase and PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature; peptidyl-prolyl cis-trans isomerase B complement(966831..967340) Neisseria meningitidis Z2491 906978 YP_002342423.1 CDS NMA1003 NC_003116.1 967459 968874 R NMA1003, probable transmembrane transport protein,len: 471 aa; similar to many e.g. to part of SW:PH87_YEAST (EMBL:X56909), PHO87, Saccharomyces cerevisiae inorganic phosphate transporter (923 aa), fasta scores; E(): 6.2e-20, 27.1% identity in 425 aa overlap and to hypothetical transporters e.g. SW:Y608_HAEIN (EMBL:U32743), HI0608, Haemophilus influenzae hypothetical protein (461 aa), fasta scores; E(): 0, 56.3% identity in 448 aa overlap. Contains Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region and PS01271 Sodium:sulfate symporter family signature. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein complement(967459..968874) Neisseria meningitidis Z2491 906979 YP_002342424.1 CDS NMA1003A NC_003116.1 969207 969467 R hypothetical protein complement(969207..969467) Neisseria meningitidis Z2491 7163865 YP_002342425.1 CDS pth NC_003116.1 969731 970309 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(969731..970309) Neisseria meningitidis Z2491 906980 YP_002342426.1 CDS NMA1005 NC_003116.1 970362 970640 R NMA1005, len: 92 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YFJF_HAEIN (EMBL:U32723),HI0395, Haemophilus influenzae hypothetical protein (102 aa), fasta scores; E(): 2.6e-14, 48.3% identity in 89 aa overlap; hypothetical protein complement(970362..970640) Neisseria meningitidis Z2491 906981 YP_002342427.1 CDS NMA1006 NC_003116.1 970633 971076 R NMA1006, len: 147 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:O68560 (EMBL:AF050676) Pseudomonas aeruginosa hypothetical protein (144 aa),fasta scores; E(): 1.8e-17, 34.5% identity in 139 aa overlap; hypothetical protein complement(970633..971076) Neisseria meningitidis Z2491 906982 YP_002342428.1 CDS NMA1007 NC_003116.1 971286 973253 R NMA1007, ftsH, probable ATP-dependent zinc metallopeptidase, len: 655 aa; similar to many e.g. SW:FTSH_ECOLI (EMBL:M83138), ftsH, Escherichia coli cell division protein (EC 3.4.24.-) (644 aa), fasta scores; E(): 0, 58.5% identity in 646 aa overlap. Contains Pfam matches to entry PF00004 AAA, ATPases associated with various cellular activities (AAA) and to entry PF01434 Peptidase_M41, Peptidase family M41, PS00674 AAA-protein family signature and two PS00017 ATP/GTP-binding site motif A (P-loop). Contains hydrophobic, probable membrane-spanning regions; ATP-dependent zinc metallopeptidase complement(971286..973253) Neisseria meningitidis Z2491 906983 YP_002342429.1 CDS NMA1008 NC_003116.1 973317 973937 R NMA1008, ftsJ, probable cell division protein, len: 106 aa; similar to many e.g. SW:FTSJ_ECOLI (EMBL:M83138),ftsJ, Escherichia coli cell division protein (209 aa),fasta scores; E(): 0, 49.0% identity in 204 aa overlap; cell division protein complement(973317..973937) Neisseria meningitidis Z2491 906984 YP_002342430.1 CDS NMA1009 NC_003116.1 974047 974331 D NMA1009, len: 94 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YHBY_HAEIN (EMBL:U32812),HI1333, Haemophilus influenzae hypothetical protein (99 aa), fasta scores; E(): 5.3e-12, 48.9% identity in 90 aa overlap; hypothetical protein 974047..974331 Neisseria meningitidis Z2491 906985 YP_002342431.1 CDS hemB NC_003116.1 974499 975515 D catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 974499..975515 Neisseria meningitidis Z2491 906987 YP_002342432.1 CDS NMA1012 NC_003116.1 975578 976735 R NMA1012, probable carbon-sulphur lyase, len: 385 aa; similar to many members of the pyridoxal-phosphate dependent cysteine and methionine metabolism family e.g. SW:MEGL_PSEPU (EMBL:D88554), mdeA, Pseudomonas putida methionine gamma-lyase (EC 4.4.1.11) (398 aa), fasta scores; E(): 0, 39.3% identity in 402 aa overlap and SW:METB_ECOLI (EMBL:K01546), metB, Escherichia coli cystathionine gamma-synthase (EC 4.2.99.9) (386 aa), fasta scores; E(): 0, 39.4% identity in 376 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site; carbon-sulfur lyase complement(975578..976735) Neisseria meningitidis Z2491 906988 YP_002342433.1 CDS NMA1013 NC_003116.1 976927 977700 D similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis; GTP cyclohydrolase 976927..977700 Neisseria meningitidis Z2491 906989 YP_002342434.1 CDS NMA1015 NC_003116.1 977900 978565 D NMA1015, probable NAD(P)H-flavin oxidoreductase,len: 221 aa; similar to many e.g. SW:NFNB_SALTY (EMBL:X17250), nfnB, Salmonella typhimurium oxygen-insensitive NAD(P)H nitroreductase (EC 1.-.-.-) (217 aa), fasta scores; E(): 8.7e-13, 31.4% identity in 223 aa overlap and SW:NFNB_ECOLI (EMBL:D25414), nfnB,Escherichia coli dihydropteridine reductase (EC 1.6.99.7) (217 aa), fasta scores; E(): 3.6e-11, 31.5% identity in 219 aa overlap. Contains Pfam match to entry PF00881 Nitroreductase, Nitroreductase family; NAD(P)H-flavin oxidoreductase 977900..978565 Neisseria meningitidis Z2491 906991 YP_002342435.1 CDS NMA1016 NC_003116.1 978620 979378 R NMA1016, probable RNA-binding protein, len: 252 aa; shows weak similarity to pseudouridine synthases e.g. SW:RSUA_ECOLI (EMBL:U00008), rluA, Escherichia coli ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) (231 aa), fasta scores; E(): 1.4e-09, 30.2% identity in 242 aa overlap. Also shows weak similarity to NMA1573, fasta scores; E(): 4.2e-13, 35.5% identity in 248 aa overlap and NMA1508, fasta scores; E(): 2.7e-10, 26.1% identity in 241 aa overlap. Contains Pfam match to entry PF01479 S4, S4 domain; RNA-binding protein complement(978620..979378) Neisseria meningitidis Z2491 906992 YP_002342436.1 CDS ppnK NC_003116.1 979403 980293 R catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase complement(979403..980293) Neisseria meningitidis Z2491 906993 YP_002342437.1 CDS NMA1018 NC_003116.1 980313 980879 R NMA1018, len: 188 aa; unknown; hypothetical protein complement(980313..980879) Neisseria meningitidis Z2491 906994 YP_002342438.1 CDS NMA1019 NC_003116.1 980930 981706 R NMA1019, len: 258 aa; unknown, similar to SW:YEEZ_ECOLI (EMBL:AE000293), yeeZ, Escherichia coli hypothetical protein (274 aa), fasta scores; E(): 6e-17,30.9% identity in 256 aa overlap; hypothetical protein complement(980930..981706) Neisseria meningitidis Z2491 906995 YP_002342439.1 CDS NMA1020 NC_003116.1 981761 982411 R NMA1020, probable tetR-family transcriptional regulator, len: 216 aa; similar to many e.g. to the N-terminus of TR:Q9Z480 (EMBL:AF090987), tetR,Agrobacterium tumefaciens C58 transcriptional repressor (215 aa), fasta scores; E(): 0.00072, 40.0% identity in 75 aa overlap and to regulators e.g. .Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Contains a probable helix-turn-helix motif at aa 32-53 (Score 1664, +4.85 SD); tetR-family transcriptional regulator complement(981761..982411) Neisseria meningitidis Z2491 906996 YP_002342440.1 CDS murB NC_003116.1 982423 983463 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(982423..983463) Neisseria meningitidis Z2491 906997 YP_002342441.1 CDS NMA1022 NC_003116.1 983641 985020 R NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein complement(983641..985020) Neisseria meningitidis Z2491 906998 YP_002342442.1 CDS hisZ NC_003116.1 985355 986506 D May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine; ATP phosphoribosyltransferase 985355..986506 Neisseria meningitidis Z2491 906999 YP_002342443.1 CDS purA NC_003116.1 986609 987907 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 986609..987907 Neisseria meningitidis Z2491 907000 YP_002342444.1 CDS NMA1025 NC_003116.1 988026 988286 D NMA1025, len: 86 aa; unknown; hypothetical protein 988026..988286 Neisseria meningitidis Z2491 907001 YP_002342445.1 CDS NMA1026 NC_003116.1 988319 988756 D NMA1026, len: 127 aa; unknown, similar to others from Neisseria meningitidis e.g. NMA1028, fasta scores; E(): 1.3e-13, 35.4% identity in 130 aa overlap, also to NMA1027 and NMA0096; hypothetical protein 988319..988756 Neisseria meningitidis Z2491 907002 YP_002342446.1 CDS NMA1027 NC_003116.1 988770 989180 D NMA1027, DNA-binding protein, len: 136 aa; similar to others from Neisseria meningitidis e.g. NMA1028, fasta scores; E(): 7e-21, 42.7% identity in 131 aa overlap, also to NMA0096 and NMA1026. Contains probable helix-turn-helix motif at aa 96-117 (Score 1404, +3.97 SD); DNA-binding protein 988770..989180 Neisseria meningitidis Z2491 907003 YP_002342447.1 CDS NMA1028 NC_003116.1 989297 989689 D NMA1028, DNA-binding protein, len: 130 aa; similar to others from Neisseria meningitidis e.g. NMA1027, fasta scores; E(): 1.4e-20, 42.7% identity in 131 aa overlap, also to NMA0096 and NMA1026. Contains probable helix-turn-helix motif at aa 90-111 (Score 1103, +2.94 SD); DNA-binding protein 989297..989689 Neisseria meningitidis Z2491 907004 YP_002342448.1 CDS NMA1030 NC_003116.1 989952 990455 D NMA1030, len: 167 aa; unknown; hypothetical protein 989952..990455 Neisseria meningitidis Z2491 907006 YP_002342449.1 CDS htpX NC_003116.1 990756 991595 R metalloprotease; heat shock protein HtpX complement(990756..991595) Neisseria meningitidis Z2491 907007 YP_002342450.1 CDS adk NC_003116.1 991810 992457 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 991810..992457 Neisseria meningitidis Z2491 907008 YP_002342451.1 CDS pyrF NC_003116.1 992983 993723 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 992983..993723 Neisseria meningitidis Z2491 907009 YP_002342452.1 CDS NMA1034 NC_003116.1 993778 994749 D NMA1034, rfaE, probable ADP-heptose synthetase,len: 323 aa; similar to many e.g. SW:RFAE_ECOLI (EMBL:AE000387), rfaE, Escherichia coli ADP-heptose synthase (EC 2.7.-.-) (477 aa), fasta scores; E(): 0,50.5% identity in 309 aa overlap and to TR:AAD32179 (EMBL:AF125564), rfaE, Neisseria meningitidis ADP-heptose synthetase (fragment) (313 aa), fasta scores; E(): 0, 96.8% identity in 313 aa overlap. Contains PS00583 pfkB family of carbohydrate kinases signature 1; DP-heptose synthetase 993778..994749 Neisseria meningitidis Z2491 907010 YP_002342453.1 CDS NMA1035 NC_003116.1 994786 996021 D NMA1035, nmgII, probable modification methylase,len: 411 aa; similar to many e.g. SW:MTS2_SHISO (EMBL:M86545), ssoIIM, Shigella sonnei modification methylase (EC ) (379 aa), fasta scores; E(): 6e-30, 31.7% identity in 398 aa overlap and to TR:AAD32180 (EMBL:AF125564), nmgII, Neisseria meningitidis NMB site specific dna methyltransferase (411 aa),E(): 0, 99.3% identity in 411 aa overlap. Similar to others from Neisseria meningitidis e.g. NMA1453, fasta scores; E(): 1.6e-23, 29.4% identity in 432 aa overlap. Contains two Pfam matches to entry PF00145 DNA_methylase,C-5 cytosine-specific DNA methylase, PS00095 C-5 cytosine-specific DNA methylases C-terminal signature and PS00094 C-5 cytosine-specific DNA methylases active site; modification methylase 994786..996021 Neisseria meningitidis Z2491 907011 YP_002342454.1 CDS NMA1036 NC_003116.1 996023 997141 D NMA1036, nmgI, type II restriction endonuclease, len: 372 aa; shows weak similarity to the C-termini of restriction endonucleases e.g. TR:O30359 (EMBL:AF001598), dcrH, Neisseria gonorrhoeae restriction endonuclease (374 aa), fasta scores; E(): 1e-05, 33.0% identity in 109 aa overlap. Similar to TR:AAD32181 (EMBL:AF125564), nmgI, Neisseria meningitidis NMB restriction endonuclease (374 aa), fasta scores; E(): 0,97.9% identity in 374 aa overlap. Lies within a region of unusually low GC content, adjacent to a modification methylase; type II restriction endonuclease 996023..997141 Neisseria meningitidis Z2491 907012 YP_002342455.1 CDS NMA1037 NC_003116.1 997182 998186 D NMA1037, rfaD, probable ADP-L-glycero-D-mannoheptose epimerase, len: 334 aa; similar to many e.g. SW:RFAD_ECOLI (EMBL:M33577), rfaD,Escherichia coli ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) (310 aa), fasta scores; E(): 0, 52.7% identity in 328 aa overlap. Also highly similar to TR:Q51061 (EMBL:L07845), gme, Neisseria gonorrhoeae ADP-L-glycero-D-mannoheptose epimerase (334 aa), fasta scores; E(): 0, 97.0% identity in 334 aa overlap. Similar to others from Neisseria meningitidis e.g. NMA0203, fasta scores; E(): 9.3e-10, 25.5% identity in 333 aa overlap,also similar to NMA0189 and NMA0204. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family; ADP-L-glycero-D-mannoheptose epimerase 997182..998186 Neisseria meningitidis Z2491 907013 YP_002342456.1 CDS NMA1038 NC_003116.1 998259 999803 D NMA1038, probable type I restriction-modification system protein, len: 514 aa; similar to many e.g. SW:T1M1_ECOLI (EMBL:X13145), hsdM, Escherichia coli type I restriction enzyme protein M (EC 2.1.1.72) (520 aa), fasta scores; E(): 0, 75.8% identity in 512 aa overlap. Contains PS00092 N-6 Adenine-specific DNA methylases signature; type I restriction-modification system protein 998259..999803 Neisseria meningitidis Z2491 907014 YP_002342457.1 CDS NMA1039 NC_003116.1 999800 1000810 D NMA1039, DNA-binding protein, len: 336 aa; similar, in part, to TR:Q9Z627 (EMBL:AF106566), rhuM,Salmonella typhimurium hypothetical protein from SPI-3 pathogenicity island (215 aa), fasta scores; E(): 7.8e-28,43.9% identity in 187 aa overlap. Contains a probable helix-turn-helix motif at aa 27-48 (Score 1542, +4.44 SD); DNA-binding protein 999800..1000810 Neisseria meningitidis Z2491 907015 YP_002342458.1 CDS NMA1045 NC_003116.1 1005418 1007697 R NMA1045, clpA, probable ATP-dependent protease ATP-binding protein, len: 759 aa; similar to many e.g. SW:CLPA_ECOLI (EMBL:M31045), clpA, Escherichia coli ATP-dependent Clp protease ATP-binding subunit (758 aa),fasta scores; E(): 0, 56.2% identity in 762 aa overlap. Similar to NMA1683, fasta scores; E(): 0, 37.2% identity in 844 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B, PS00870 Chaperonins clpA/B signature 1, PS00871 Chaperonins clpA/B signature 2 and two PS00017 ATP/GTP-binding site motif A (P-loop); ATP-dependent protease ATP-binding protein complement(1005418..1007697) Neisseria meningitidis Z2491 907018 YP_002342459.1 CDS clpS NC_003116.1 1007701 1008012 R involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS complement(1007701..1008012) Neisseria meningitidis Z2491 907019 YP_002342460.1 CDS NMA1047 NC_003116.1 1008270 1008473 D NMA1047, cspA, probable transcriptional regulator,len: 67 aa; similar to many cold-shock proteins e.g. SW:CSPA_ECOLI (EMBL:M30139), cspA, Escherichia coli cold shock protein (69 aa), fasta scores; E(): 1e-15, 64.5% identity in 62 aa overlap. Contains PS00352 'Cold-shock' DNA-binding domain signature; transcriptional regulator 1008270..1008473 Neisseria meningitidis Z2491 907020 YP_002342461.1 CDS NMA1048 NC_003116.1 1008771 1010102 R NMA1048, len: 443 aa; unknown, similar to many e.g. SW:PMBA_ECOLI (EMBL:X54152), pmbA, Escherichia coli protein possibly involved in the control of DNA gyrase (450 aa), fasta scores; E(): 0, 50.4% identity in 425 aa overlap. Contains Pfam match to entry PF01523 PmbA_TldD, modulator of DNA gyrase; hypothetical protein complement(1008771..1010102) Neisseria meningitidis Z2491 907021 YP_002342462.1 CDS NMA1049 NC_003116.1 1010193 1010768 D NMA1049, len: 191 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YJGA_HAEIN (EMBL:U32794),HI1151, Haemophilus influenzae hypothetical protein (178 aa), fasta scores; E(): 9.4e-19, 36.4% identity in 176 aa overlap; hypothetical protein 1010193..1010768 Neisseria meningitidis Z2491 907022 YP_002342463.1 CDS NMA1051 NC_003116.1 1010815 1011528 D NMA1051, membrane protein, len: 237 aa; unknown, contains probable N-terminal signal sequence and hydrophobic, membrane-spanning region; hypothetical protein 1010815..1011528 Neisseria meningitidis Z2491 907023 YP_002342464.1 CDS NMA1052 NC_003116.1 1011597 1013297 D NMA1052, recJ, probable single-stranded-DNA-specific exonuclease, len: 566 aa; similar to many e.g. SW:RECJ_ECOLI (EMBL:M54884), recJ,Escherichia coli single-stranded-DNA-specific exonuclease (EC 3.1.-.-) (577 aa), fasta scores; E(): 0, 47.9% identity in 584 aa overlap. Contains Pfam match to entry PF01368 DHH, DHH family; single-stranded-DNA-specific exonuclease 1011597..1013297 Neisseria meningitidis Z2491 907024 YP_002342465.1 CDS NMA1053 NC_003116.1 1013598 1014959 D NMA1053, pcnB, probable poly(A) polymerase, len: 453 aa; similar to many e.g. SW:PCNB_ECOLI (EMBL:M20574),pcnB, Escherichia coli poly(A) polymerase (EC 2.7.7.19) (472 aa), fasta scores; E(): 0, 41.3% identity in 441 aa overlap; poly(A) polymerase 1013598..1014959 Neisseria meningitidis Z2491 907025 YP_002342466.1 CDS NMA1054 NC_003116.1 1015129 1015455 D NMA1054, periplasmic protein, len: 108 aa; unknown, contains probable N-terminal signal sequence; hypothetical protein 1015129..1015455 Neisseria meningitidis Z2491 907026 YP_002342467.1 CDS NMA1056 NC_003116.1 1015560 1016513 R NMA1056, len: 317 aa; unknown, similar to many bacterial proteins of the phoH family e.g. SW:PHOL_ECOLI (EMBL:AE000170), ybeZ, Escherichia coli hypothetical protein (359 aa), fasta scores; E(): 0, 58.1% identity in 320 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein complement(1015560..1016513) Neisseria meningitidis Z2491 907027 YP_002342468.1 CDS NMA1059 NC_003116.1 1018045 1018749 D NMA1059, periplasmic protein, len: 234 aa; unknown, contains probable N-terminal signal sequence; hypothetical protein 1018045..1018749 Neisseria meningitidis Z2491 907030 YP_002342469.1 CDS dcd NC_003116.1 1018813 1019379 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(1018813..1019379) Neisseria meningitidis Z2491 907031 YP_002342470.1 CDS NMA1061 NC_003116.1 1019445 1019861 R NMA1061, periplasmic protein, len: 138 aa; unknown, contains probable N-terminal signal sequence; hypothetical protein complement(1019445..1019861) Neisseria meningitidis Z2491 907032 YP_002342471.1 CDS rdgC NC_003116.1 1019913 1020812 R Required for efficient pilin antigenic variation; recombination associated protein complement(1019913..1020812) Neisseria meningitidis Z2491 907033 YP_002342472.1 CDS engA NC_003116.1 1020843 1022300 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(1020843..1022300) Neisseria meningitidis Z2491 907034 YP_002342473.1 CDS NMA1064 NC_003116.1 1022454 1023083 R NMA1064, membrane protein, len: 209 aa; similar to SW:GC_NEIGO (EMBL:AF058711) Neisseria gonorrhoeae unknown protein (209 aa), fasta scores; E(): 0, 98.1% identity in 209 aa overlap and to bacterial hypothetical proteins. Contains hydrophobic, membrane-spanning region; hypothetical protein complement(1022454..1023083) Neisseria meningitidis Z2491 907035 YP_002342474.1 CDS hisS NC_003116.1 1023084 1024379 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1023084..1024379) Neisseria meningitidis Z2491 907036 YP_002342475.1 CDS NMA1066 NC_003116.1 1024473 1025129 R NMA1066, periplasmic protein, len: 218 aa; shows weak similarity to part of TR:O53037 (EMBL:U68399),hmcC, Haemophilus influenzae protein implicated in haemocin production (198 aa), fasta scores; E(): 4.3e-12,33.6% identity in 146 aa overlap. Also highly similar to other proteins from Neisseria meningitidis, NMA0173, fasta scores; E(): 0, 70.7% identity in 164 aa overlap and NMA0767, fasta scores; E(): 0, 88.3% identity in 128 aa overlap. Contains a probable N-terminal signal sequence; hypothetical protein complement(1024473..1025129) Neisseria meningitidis Z2491 907037 YP_002342476.1 CDS NMA1068 NC_003116.1 1025411 1025947 R NMA1068, len: 178 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(1025411..1025947) Neisseria meningitidis Z2491 907039 YP_002342477.1 CDS NMA1070 NC_003116.1 1026115 1026315 R NMA1070, len: 66 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(1026115..1026315) Neisseria meningitidis Z2491 907040 YP_002342478.1 CDS NMA1071 NC_003116.1 1026430 1026849 R NMA1071, len: 139 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(1026430..1026849) Neisseria meningitidis Z2491 907041 YP_002342479.1 CDS NMA1072 NC_003116.1 1026907 1027272 R NMA1072, len: 121 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(1026907..1027272) Neisseria meningitidis Z2491 907042 YP_002342480.1 CDS NMA1073 NC_003116.1 1027254 1027799 R NMA1073, len: 181 aa; unknown, similar to parts others from Neisseria meningitidis e.g. NMA1083, fasta scores; E(): 3.3e-17, 65.6% identity in 93 aa overlap,also to NMA1078. Lies within a region of unusually low GC content; hypothetical protein complement(1027254..1027799) Neisseria meningitidis Z2491 907043 YP_002342481.1 CDS NMA1074 NC_003116.1 1027962 1028234 R NMA1074, membrane protein, len: 90 aa; unknown, contains hydrophobic, membrane-spanning regions. Lies within a region of unusually low GC content; hypothetical protein complement(1027962..1028234) Neisseria meningitidis Z2491 907044 YP_002342482.1 CDS NMA1075 NC_003116.1 1028500 1028790 R hypothetical protein complement(1028500..1028790) Neisseria meningitidis Z2491 907045 YP_002342483.1 CDS NMA1077 NC_003116.1 1029110 1029358 R NMA1077, len: 82 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(1029110..1029358) Neisseria meningitidis Z2491 907047 YP_002342484.1 CDS NMA1078 NC_003116.1 1029404 1029772 R NMA1078, len: 122 aa; unknown, similar to parts others from Neisseria meningitidis e.g. NMA1073, fasta scores; E(): 8.4e-14, 64.6% identity in 79 aa overlap,also to NMA1083. Lies within a region of unusually low GC content; hypothetical protein complement(1029404..1029772) Neisseria meningitidis Z2491 907048 YP_002342485.1 CDS NMA1079 NC_003116.1 1029914 1030159 R NMA1079, len: 81 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(1029914..1030159) Neisseria meningitidis Z2491 907049 YP_002342486.1 CDS NMA1080 NC_003116.1 1030388 1030504 R NMA1080, len: 38 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(1030388..1030504) Neisseria meningitidis Z2491 907050 YP_002342487.1 CDS NMA1081 NC_003116.1 1030563 1030850 R NMA1081, membrane protein, len: 95 aa; unknown, contains hydrophobic, membrane-spanning regions, lies within a region of unusually low GC content; hypothetical protein complement(1030563..1030850) Neisseria meningitidis Z2491 907051 YP_002342488.1 CDS NMA1082 NC_003116.1 1031157 1031528 R NMA1082, len: 123 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(1031157..1031528) Neisseria meningitidis Z2491 907052 YP_002342489.1 CDS NMA1083 NC_003116.1 1031662 1032105 R NMA1083, periplasmic protein, len: 147 aa; unknown, similar to parts of other proteins from Neisseria meningitidis e.g. NMA1073, fasta scores; E(): 1.4e-17,65.6% identity in 93 aa overlap, also to NMA1078. Contains probable N-terminal signal sequence. Lies within a region of unusually low GC content; hypothetical protein complement(1031662..1032105) Neisseria meningitidis Z2491 907053 YP_002342490.1 CDS NMA1084 NC_003116.1 1032148 1033017 R NMA1084, periplasmic protein, len: 289 aa; shows weak similarity to TR:O53036 (EMBL:U68399), hmcD,Haemophilus influenzae protein at haemocin immunity locus (297 aa), fasta scores; E(): 3.7e-07, 24.6% identity in 289 aa overlap. Similar to part of NMA0171, fasta scores; E(): 1.2e-09, 54.7% identity in 53 aa overlap. Contains probable N-terminal signal sequence; hypothetical protein complement(1032148..1033017) Neisseria meningitidis Z2491 907054 YP_002342491.1 CDS NMA1085 NC_003116.1 1033181 1034104 D NMA1085, len: 307 aa; similar to TR:O07166 (EMBL:Z96070) Mycobacterium tuberculosis hypothetical protein (305 aa), fasta scores; E(): 0, 42.9% identity in 282 aa overlap and shows weak similarity to many,including pseudouridine synthases. Contains Pfam match to entry PF00849 YABO, Hypothetical yabO/yceC/sfhB family; hypothetical protein 1033181..1034104 Neisseria meningitidis Z2491 907055 YP_002342492.1 CDS NMA1086 NC_003116.1 1034182 1034823 R NMA1086, len: 213 aa; shows weak similarity to TR:Q9ZD73 (EMBL:AJ235271), RP471, Rickettsia prowazekii hypothetical protein (238 aa), fasta scores; E(): 1.4e-10,30.3% identity in 198 aa overlap; hypothetical protein complement(1034182..1034823) Neisseria meningitidis Z2491 907056 YP_002342493.1 CDS NMA1087 NC_003116.1 1034878 1035669 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(1034878..1035669) Neisseria meningitidis Z2491 907057 YP_002342494.1 CDS panB NC_003116.1 1036052 1036843 D catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 1036052..1036843 Neisseria meningitidis Z2491 907058 YP_002342495.1 CDS panC NC_003116.1 1036966 1037802 D catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 1036966..1037802 Neisseria meningitidis Z2491 907059 YP_002342496.1 CDS NMA1090 NC_003116.1 1037967 1039805 D NMA1090, periplasmic protein, len: 612 aa; shows weak similarity to hypothetical proteins e.g. SW:YHE3_PSEAE (EMBL:X82071) Pseudomonas aeruginosa hypothetical protein (576 aa), fasta scores; E(): 1.7e-15,26.4% identity in 613 aa overlap. Contains probable N-terminal signal sequence; hypothetical protein 1037967..1039805 Neisseria meningitidis Z2491 907060 YP_002342497.1 CDS lolB NC_003116.1 1039945 1040526 D Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1039945..1040526 Neisseria meningitidis Z2491 907061 YP_002342498.1 CDS ipk NC_003116.1 1040536 1041381 D An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1040536..1041381 Neisseria meningitidis Z2491 907062 YP_002342499.1 CDS prsA NC_003116.1 1041803 1042786 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1041803..1042786 Neisseria meningitidis Z2491 907063 YP_002342500.1 CDS NMA1094 NC_003116.1 1042853 1043425 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 1042853..1043425 Neisseria meningitidis Z2491 907064 YP_002342501.1 CDS NMA1095 NC_003116.1 1043550 1044719 R NMA1095, probable D-alanyl-D-alanine carboxypeptidase, len: 389 aa; similar to many e.g. SW:DACC_ECOLI (EMBL:X06480), dacC, Escherichia coli D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) (400 aa), fasta scores; E(): 0, 36.3% identity in 364 aa overlap. Similar to NMA0962, fasta scores; E(): 8.4e-14,29.6% identity in 243 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase. Contains probable N-terminal signal sequence; D-alanyl-D-alanine carboxypeptidase complement(1043550..1044719) Neisseria meningitidis Z2491 907065 YP_002342502.1 CDS ilvA NC_003116.1 1044867 1046393 D threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 1044867..1046393 Neisseria meningitidis Z2491 907066 YP_002342503.1 CDS NMA1097 NC_003116.1 1046450 1047523 R NMA1097, cysA, probable sulphate permease ATP-binding protein, len: 357 aa; similar to many e.g. SW:CYSA_ECOLI (EMBL:M32101), cysA, Escherichia coli sulfate transport ATP-binding protein (365 aa), fasta scores; E(): 0, 49.4% identity in 360 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter,PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); sulfate permease ATP-binding protein complement(1046450..1047523) Neisseria meningitidis Z2491 907067 YP_002342504.1 CDS NMA1098 NC_003116.1 1047520 1048380 R NMA1098, cysW, probable sulphate permease inner membrane protein, len: 286 aa; similar to many e.g. SW:CYSW_ECOLI (EMBL:M32101), cysW, Escherichia coli sulfate transport system permease (291 aa), fasta scores; E(): 0, 51.7% identity in 265 aa overlap. Contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component and PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains hydrophobic,probable membrane-spanning regions; sulfate permease inner membrane protein complement(1047520..1048380) Neisseria meningitidis Z2491 907068 YP_002342505.1 CDS NMA1100 NC_003116.1 1048758 1049594 R NMA1100, cysU, probable sulphate permease inner membrane protein, len: 278 aa; similar to many e.g. SW:CYST_ECOLI (EMBL:M32101), cysU, Escherichia coli sulfate transport system permease (277 aa), fasta scores; E(): 0, 48.4% identity in 273 aa overlap. Contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component and PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains hydrophobic,probable membrane-spanning regions; sulfate permease inner membrane protein complement(1048758..1049594) Neisseria meningitidis Z2491 907070 YP_002342506.1 CDS NMA1101 NC_003116.1 1049885 1050217 D NMA1101, len: 110 aa; unknown, Glu-rich protein; hypothetical protein 1049885..1050217 Neisseria meningitidis Z2491 907071 YP_002342507.1 CDS NMA1102 NC_003116.1 1050549 1051058 D NMA1102, integral membrane protein, len: 169 aa; similar to bacterial hypothetical proteins e.g. SW:Y318_HAEIN (EMBL:U32717), HI0318, Haemophilus influenzae (172 aa), fasta scores; E(): 0, 56.2% identity in 169 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains hydrophobic, membrane-spanning regions. Lies within a region of unusually low GC content; integral membrane protein 1050549..1051058 Neisseria meningitidis Z2491 907072 YP_002342508.1 CDS NMA1104 NC_003116.1 1052308 1052895 R NMA1104, sodB, probable superoxide dismutase, len: 195 aa; highly similar to many e.g. SW:SODF_BORPE (EMBL:X63055), sodF, Bordetella pertussis superoxide dismutase [Fe] (EC 1.15.1.1) (192 aa), fasta scores; E(): 0, 72.9% identity in 192 aa overlap. Contains Pfam match to entry PF00081 sodfe, Iron/manganese superoxide dismutases (SODM) and PS00088 Manganese and iron superoxide dismutases signature; superoxide dismutase complement(1052308..1052895) Neisseria meningitidis Z2491 907073 YP_002342509.1 CDS dnaB NC_003116.1 1053058 1054464 D unwinds double stranded DNA; replicative DNA helicase 1053058..1054464 Neisseria meningitidis Z2491 907074 YP_002342510.1 CDS NMA1106 NC_003116.1 1054773 1055438 D NMA1106, len: 221 aa; unknown, N-terminus is similar to the N-termini of fimbrial proteins e.g. TR:Q51528 (EMBL:L48934), fimT, Pseudomonas aeruginosa fimbrial protein (169 aa), fasta scores; E(): 0.00046,31.5% identity in 108 aa overlap. Contains N-terminal signal sequence, similar to that present in others from Neisseria meningitidis: NMA0264, NMA1110,NMA0726, NMA0424, which are all pilin-related; hypothetical protein 1054773..1055438 Neisseria meningitidis Z2491 907075 YP_002342511.1 CDS NMA1107 NC_003116.1 1055468 1056082 D NMA1107, membrane protein, len: 204 aa; unknown, N-terminus is similar to the N-terminus of TR:Q57003 (EMBL:L36117), pilV, Pseudomonas aeruginosa gene required for type 4 fimbrial biogenesis (185 aa), fasta scores; E(): 0.00046, 25.1% identity in 183 aa overlap. Contains hydrophobic, membrane-spanning region near the N-terminus; hypothetical protein 1055468..1056082 Neisseria meningitidis Z2491 907076 YP_002342512.1 CDS NMA1108 NC_003116.1 1056079 1057077 D NMA1108, membrane protein, len: 332 aa; unknown, contains hydrophobic, membrane-spanning region near the N-terminus; hypothetical protein 1056079..1057077 Neisseria meningitidis Z2491 907077 YP_002342513.1 CDS NMA1109 NC_003116.1 1057056 1057649 D NMA1109, membrane protein, len: 197 aa; unknown, contains hydrophobic, membrane-spanning region near the N-terminus; hypothetical protein 1057056..1057649 Neisseria meningitidis Z2491 907078 YP_002342514.1 CDS NMA1110 NC_003116.1 1057639 1058127 D NMA1110, probable pilin, len: 162 aa; similar to many e.g. SW:FMI_MORBO (EMBL:M32345) Moraxella bovis fimbrial protein I precursor (159 aa), fasta scores; E(): 6.4e-06, 28.1% identity in 153 aa overlap. Contains Pfam match to entry PF00114 pilin, Pilins (bacterial filaments) and PS00409 Prokaryotic N-terminal methylation site. Contains probable N-terminal signal sequence; pilin 1057639..1058127 Neisseria meningitidis Z2491 907079 YP_002342515.1 CDS NMA1111 NC_003116.1 1059437 1059919 R NMA1111, len: 160 aa; shows weak similarity to N-terminal regions of bacterial hypothetical proteins e.g. SW:YGAZ_ECOLI (EMBL:AE000353), ygaZ, Escherichia coli hypothetical protein (245 aa), fasta scores; E(): 1.7e-05,28.4% identity in 116 aa overlap; hypothetical protein complement(1059437..1059919) Neisseria meningitidis Z2491 907080 YP_002342516.1 CDS dut NC_003116.1 1060062 1060514 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1060062..1060514 Neisseria meningitidis Z2491 907081 YP_002342517.1 CDS NMA1113 NC_003116.1 1060590 1061777 D catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate; succinyldiaminopimelate transaminase 1060590..1061777 Neisseria meningitidis Z2491 907082 YP_002342518.1 CDS NMA1114 NC_003116.1 1062039 1062818 D NMA1114, len: 259 aa; similar to bacterial hypothetical proteins e.g. SW:YAAA_ECOLI (EMBL:D10483),yaaA, Escherichia coli hypothetical protein (258 aa),fasta scores; E(): 0, 54.9% identity in 257 aa overlap; hypothetical protein 1062039..1062818 Neisseria meningitidis Z2491 907083 YP_002342519.1 CDS NMA1115 NC_003116.1 1063489 1064496 R NMA1115, probable transposase for IS1106A3, len: 335 aa; similar to many e.g. TR:CAB44967 (EMBL:AJ242841),Neisseria meningitidis transposase for insertion element IS1106A3 (335 aa), fasta scores; E(): 0, 97.6% identity in 335 aa overlap; transposase for IS1106A3 complement(1063489..1064496) Neisseria meningitidis Z2491 907084 YP_002342520.1 CDS NMA1116 NC_003116.1 1065658 1067883 R NMA1116, icd, probable isocitrate dehydrogenase,len: 741 aa; similar to many e.g. SW:IDH_AZOVI (EMBL:D73443), icd, Azotobacter vinelandii isocitrate dehydrogenase (EC 1.1.1.42) (741 aa), fasta scores; E(): 0, 65.6% identity in 735 aa overlap; isocitrate dehydrogenase complement(1065658..1067883) Neisseria meningitidis Z2491 907085 YP_002342521.1 CDS NMA1118 NC_003116.1 1068316 1069431 D NMA1118, lst,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3- sialyltransferase, len: 371 aa; highly similar to sialyltransferases from other strains e.g. TR:P72097 (EMBL:U60661), lst, Neisseria meningitidis strains 406Y,NRCC and 4030 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3- sialyltransferase (EC 2.4.99.-) (371 aa), fasta scores; E(): 0, 98.9% identity in 371 aa overlap; CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1068316..1069431 Neisseria meningitidis Z2491 907087 YP_002342522.1 CDS NMA1119 NC_003116.1 1069595 1070053 R NMA1119, probable C-type cytochrome, len: 152 aa; similar to many e.g. SW:C554_RHOSH (EMBL:L36880), cycF,Rhodobacter sphaeroides cytochrome C-554 precursor (153 aa), fasta scores; E(): 9.9e-06, 28.4% identity in 148 aa overlap. Contains Pfam match to entry PF01322 Cytochrome_C_2, Cytochrome C', PS00190 Cytochrome c family heme-binding site signature and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; C-type cytochrome complement(1069595..1070053) Neisseria meningitidis Z2491 907088 YP_002342523.1 CDS NMA1120 NC_003116.1 1070172 1070993 D NMA1120, probable oxidoreductase, len: 273 aa; similar to many oxidoreductases e.g. TR:O54197 (EMBL:AJ000671), car, Streptomyces clavuligerus clavulanate-9-aldehyde reductase (247 aa), fasta scores; E(): 2.1e-23, 36.6% identity in 238 aa overlap and SW:FABG_ECOLI (EMBL:M84991), fabG, Escherichia coli 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) (244 aa), fasta scores; E(): 1.1e-16, 32.8% identity in 201 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and PS00061 Short-chain dehydrogenases/reductases family signature; oxidoreductase 1070172..1070993 Neisseria meningitidis Z2491 907089 YP_002342524.1 CDS NMA1121 NC_003116.1 1071044 1071490 R NMA1121, acyl-CoA hydrolase, len: 148 aa; shows weak similarity to part of SW:CTE2_RAT (EMBL:U49694) Rattus norvegicus cytosolic acyl coenzyme a thioester hydrolase (EC 3.1.2.2) (338 aa), fasta scores; E(): 4.2e-07, 31.0% identity in 113 aa overlap. Also similar to hypothetical proteins e.g. SW:YCIA_HAEIN (EMBL:U32765),HI0827, Haemophilus influenzae hypothetical protein (154 aa), fasta scores; E(): 0, 62.1% identity in 132 aa overlap. Similar to NMA1691, fasta scores; E(): 1.2e-08,27.6% identity in 127 aa overlap. Contains Pfam match to entry PF01662 Acyl-CoA_hydro, Cytosolic long-chain acyl-CoA thioester hydrolase; acyl-CoA hydrolase complement(1071044..1071490) Neisseria meningitidis Z2491 907090 YP_002342525.1 CDS NMA1122 NC_003116.1 1071772 1072704 D NMA1122, pip, probable proline iminopeptidase, len: 310 aa; similar to many e.g. SW:PIP_NEIGO (EMBL:Z25461),pip, Neisseria gonorrhoeae proline iminopeptidase (EC 3.4.11.5) (310 aa), fasta scores; E(): 0, 96.5% identity in 310 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold; proline iminopeptidase 1071772..1072704 Neisseria meningitidis Z2491 907091 YP_002342526.1 CDS NMA1123 NC_003116.1 1072761 1073888 R NMA1123, lipoprotein, len: 375 aa; unknown, contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a N-terminal signal sequence; lipoprotein complement(1072761..1073888) Neisseria meningitidis Z2491 907092 YP_002342527.1 CDS dapA NC_003116.1 1073966 1074841 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(1073966..1074841) Neisseria meningitidis Z2491 907093 YP_002342528.1 CDS NMA1126 NC_003116.1 1075149 1076540 D NMA1126, probable transmembrane transport protein,len: 463 aa; similar to many from both prokaryotes and eukaryotes e.g. SW:UAPC_EMENI (EMBL:X79796), uapC,Emericella nidulans purine permease (580 aa), fasta scores; E(): 4.4e-22, 30.7% identity in 499 aa overlap. Also similar to hypothetical proteins e.g. SW:YGFO_ECOLI (EMBL:U28375), ygfO, Escherichia coli hypothetical protein (485 aa), fasta scores; E(): 0, 69.4% identity in 438 aa overlap. Contains Pfam match to entry PF00860 xan_ur_permease, Xanthine/uracil permeases family and PS01116 Xanthine/uracil permeases family signature. Contains hydrophobic, probable membrane-spanning regions; transmembrane transport protein 1075149..1076540 Neisseria meningitidis Z2491 907094 YP_002342529.1 CDS NMA1127 NC_003116.1 1076602 1077354 R NMA1127, RNA methylase, len: 261 aa; shows weak similarity to SW:TSNR_STRAZ (EMBL:X02392), tsnR,Streptomyces azureus rRNA (adenosine-2'-O-)-methyltransferase (EC 2.1.1.66) (269 aa), blastp scores; Expect = 4.0e-14. Similar to other hypothetical RNA methylases e.g. SW:YJFH_ECOLI (EMBL:U14003), yjfH, Escherichia coli hypothetical tRNA/tRNA methyltransferase (243 aa), fasta scores; E(): 0, 52.3% identity in 241 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family; RNA methylase complement(1076602..1077354) Neisseria meningitidis Z2491 907095 YP_002342530.1 CDS NMA1128 NC_003116.1 1077421 1077909 R NMA1128, membrane protein, len: 162 aa; similar to SW:YQGC_BACSU (EMBL:D84432), yqgC, Bacillus subtilis hypothetical protein (160 aa), fasta scores; E(): 3.6e-10, 34.2% identity in 161 aa overlap. Contains hydrophobic, membrane-spanning regions; hypothetical protein complement(1077421..1077909) Neisseria meningitidis Z2491 907096 YP_002342531.1 CDS NMA1129 NC_003116.1 1077914 1078633 R Similar to Neisseria meningitidis cytidine and deoxycytidylate deaminase family protein nmb0933 SWALL:Q9JZR1 (EMBL:AE002444) (239 aa) fasta scores: E(): 2.8e-91, 97.49% id in 239 aa, and to Bacillus subtilis hypothetical protein YaaJ yaaJ SWALL:YAAJ_BACSU (SWALL:P21335) (161 aa) fasta scores: E(): 9e-21, 40.66% id in 150 aa; NMA1129, cytosine deaminase, len: 239 aa; shows weak similarity to many e.g. SW:FCA1_CANAL (EMBL:U55194), fca1, Candida albicans cytosine deaminase (EC 3.5.4.1) (150 aa), fasta scores; E(): 5.5e-08, 31.4% identity in 140 aa overlap. Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region and PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature; cytosine deaminase complement(1077914..1078633) Neisseria meningitidis Z2491 907097 YP_002342532.1 CDS miaA NC_003116.1 1078637 1079578 R IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase complement(1078637..1079578) Neisseria meningitidis Z2491 907099 YP_002342533.1 CDS NMA1131 NC_003116.1 1079957 1081330 R hypothetical protein complement(1079957..1081330) Neisseria meningitidis Z2491 7163866 YP_002342534.1 CDS efp NC_003116.1 1081568 1082128 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 1081568..1082128 Neisseria meningitidis Z2491 907102 YP_002342535.1 CDS NMA1134 NC_003116.1 1082178 1083023 R NMA1134, lipoprotein, len: 281 aa; unknown, contains appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and probable N-terminal signal sequence; lipoprotein complement(1082178..1083023) Neisseria meningitidis Z2491 907103 YP_002342536.1 CDS NMA1135 NC_003116.1 1083140 1083721 R NMA1135, len: 193 aa; unknown, shows weak similarity to parts of hypothetical proteins e.g. TR:O32813 (EMBL:U80599) Lactococcus lactis hypothetical protein (207 aa), fasta scores; E(): 0.001, 25.6% identity in 121 aa overlap; hypothetical protein complement(1083140..1083721) Neisseria meningitidis Z2491 907104 YP_002342537.1 CDS metX NC_003116.1 1083718 1084857 R Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase complement(1083718..1084857) Neisseria meningitidis Z2491 907105 YP_002342538.1 CDS rpmJ NC_003116.1 1085479 1085604 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 complement(1085479..1085604) Neisseria meningitidis Z2491 907106 YP_002342539.1 CDS rpmE2 NC_003116.1 1085604 1085879 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(1085604..1085879) Neisseria meningitidis Z2491 907107 YP_002342540.1 CDS metF NC_003116.1 1086078 1086956 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 1086078..1086956 Neisseria meningitidis Z2491 907108 YP_002342541.1 CDS metE NC_003116.1 1087095 1089371 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 1087095..1089371 Neisseria meningitidis Z2491 907109 YP_002342542.1 CDS NMA1141 NC_003116.1 1089650 1090387 D NMA1141, redoxin, len: 245 aa; similar to many from both bacteria and eukaryotes e.g. TR:AAD28242 (EMBL:AF121355) Arabidopsis thaliana peroxiredoxin (162 aa), fasta scores; E(): 2e-17, 39.9% identity in 158 aa overlap. Contains Pfam match to entry PF00578 AhpC-TSA,AhpC/TSA family; redoxin 1089650..1090387 Neisseria meningitidis Z2491 907110 YP_002342543.1 CDS lpdA2 NC_003116.1 1090636 1092039 D Catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 1090636..1092039 Neisseria meningitidis Z2491 907111 YP_002342544.1 CDS NMA1143 NC_003116.1 1092318 1092695 D NMA1143, sdhC, probable succinate dehydrogenase cytochrome B subunit, len: 125 aa; similar to many e.g. SW:DHSC_ECOLI (EMBL:J01619), sdhC, Escherichia coli succinate dehydrogenase cytochrome B-556 subunit (129 aa),fasta scores; E(): 1.4e-14, 39.8% identity in 123 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt,Succinate dehydrogenase cytochrome b subunit and PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. Contains hydrophobic, probable membrane-spanning regions; succinate dehydrogenase cytochrome B subunit 1092318..1092695 Neisseria meningitidis Z2491 907112 YP_002342545.1 CDS NMA1144 NC_003116.1 1092689 1093030 D NMA1144, sdhD, probable succinate dehydrogenase hydrophobic membrane anchor protein, len: 113 aa; similar to SW:DHSD_ECOLI (EMBL:J01619), sdhD, Escherichia coli succinate dehydrogenase hydrophobic membrane anchor protein (115 aa), fasta scores; E(): 5e-13, 36.5% identity in 104 aa overlap. Also similar to TR:O83000 (EMBL:AB015757) Rhodoferax fermentans fumarate reductase cytochrome B small subunit (121 aa), fasta scores; E(): 1.8e-21, 48.6% identity in 111 aa overlap. Contains hydrophobic, probable membrane-spanning regions; succinate dehydrogenase hydrophobic membrane anchor protein 1092689..1093030 Neisseria meningitidis Z2491 907113 YP_002342546.1 CDS NMA1145 NC_003116.1 1093033 1094796 D NMA1145, sdhA, probable succinate dehydrogenase flavoprotein subunit, len: 587 aa; similar to many e.g. SW:DHSA_ECOLI (EMBL:J01619), sdhA, Escherichia coli succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) (588 aa), fasta scores; E(): 0, 56.6% identity in 590 aa overlap. Also similar to TR:O83001 (EMBL:AB015757) Rhodoferax fermentans fumarate reductase flavoprotein subunit (601 aa), fasta scores; E(): 0, 64.2% identity in 592 aa overlap. Similar to NMA2092, fasta scores; E(): 8.6e-31, 33.9% identity in 546 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain and PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site; succinate dehydrogenase flavoprotein subunit 1093033..1094796 Neisseria meningitidis Z2491 907114 YP_002342547.1 CDS sdhB NC_003116.1 1094916 1095623 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 1094916..1095623 Neisseria meningitidis Z2491 907115 YP_002342548.1 CDS NMA1147 NC_003116.1 1095627 1095875 D NMA1147, len: 82 aa; shows weak similarity to bacterial hypothetical proteins e.g. TR:Q9ZCV9 (EMBL:AJ235272), RP599, Rickettsia prowazekii hypothetical protein (87 aa), fasta scores; E(): 0.00085, 30.7% identity in 75 aa overlap; hypothetical protein 1095627..1095875 Neisseria meningitidis Z2491 907116 YP_002342549.1 CDS gltA NC_003116.1 1095987 1097270 D type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 1095987..1097270 Neisseria meningitidis Z2491 907117 YP_002342550.1 CDS sucA NC_003116.1 1097475 1100303 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 1097475..1100303 Neisseria meningitidis Z2491 907118 YP_002342551.1 CDS sucB NC_003116.1 1100403 1101614 D component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 1100403..1101614 Neisseria meningitidis Z2491 907119 YP_002342552.1 CDS lpdA3 NC_003116.1 1101979 1103412 D E3 component of 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 1101979..1103412 Neisseria meningitidis Z2491 907120 YP_002342553.1 CDS NMA1152 NC_003116.1 1103507 1103794 D NMA1152, membrane protein, len: 95 aa; unknown, contains hydrophobic, membrane-spanning regions and a N-terminal signal sequence; hypothetical protein 1103507..1103794 Neisseria meningitidis Z2491 907121 YP_002342554.1 CDS sucC NC_003116.1 1103893 1105059 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1103893..1105059 Neisseria meningitidis Z2491 907122 YP_002342555.1 CDS sucD NC_003116.1 1105070 1105960 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 1105070..1105960 Neisseria meningitidis Z2491 907123 YP_002342556.1 CDS NMA1155 NC_003116.1 1106195 1106524 R NMA1155, len: 120 aa; unknown, shows similarity to parts of hypothetical proteins e.g. SW:YAFM_HAEIN (EMBL:U32706), HI0217, Haemophilus influenzae hypothetical protein (176 aa), fasta scores; E(): 2.6e-15, 42.5% identity in 106 aa overlap. Similar to parts of NMA1675,fasta scores; E(): 8.4e-07, 42.7% identity in 103 aa overlap and NMA0532, fasta scores; E(): 8.4e-07, 42.7% identity in 103 aa overlap; hypothetical protein complement(1106195..1106524) Neisseria meningitidis Z2491 7163867 YP_002342557.1 CDS NMA1156 NC_003116.1 1106803 1107033 D NMA1156, len: 76 aa; unknown, lysine-rich; hypothetical protein 1106803..1107033 Neisseria meningitidis Z2491 907125 YP_002342558.1 CDS NMA1157 NC_003116.1 1107199 1107996 R NMA1157, len: 265 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(1107199..1107996) Neisseria meningitidis Z2491 907126 YP_002342559.1 CDS NMA1158 NC_003116.1 1108720 1108908 R NMA1158, len: 62 aa; unknown, lies within a region of unusually low GC content; hypothetical protein complement(1108720..1108908) Neisseria meningitidis Z2491 907127 YP_002342560.1 CDS uvrA NC_003116.1 1108965 1111811 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(1108965..1111811) Neisseria meningitidis Z2491 907128 YP_002342561.1 CDS NMA1160 NC_003116.1 1111966 1112763 D catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 1111966..1112763 Neisseria meningitidis Z2491 907129 YP_002342562.1 CDS NMA1161 NC_003116.1 1114191 1116485 R NMA1161, probable outer-membrane receptor protein,len: 764 aa; shows weak similarity to many outer-membrane receptors e.g. TR:O68881 (EMBL:AF055999), phuR,Pseudomonas aeruginosa outer membrane hemin receptor (764 aa), fasta scores; E(): 5.3e-09, 22.5% identity in 746 aa overlap and TR:P72121 (EMBL:D28119) Pseudomonas aeruginosa outer membrane protein C precursor (723 aa), fasta scores; E(): 0.00075, 21.0% identity in 794 aa overlap. Similar to NMA0474, fasta scores; E(): 2e-05, 20.8% identity in 795 aa overlap. Contains probable N-terminal signal sequence; outer-membrane receptor protein complement(1114191..1116485) Neisseria meningitidis Z2491 907130 YP_002342563.1 CDS trpG NC_003116.1 1116892 1117482 D TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1116892..1117482 Neisseria meningitidis Z2491 907132 YP_002342564.1 CDS trpD NC_003116.1 1117547 1118605 D Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1117547..1118605 Neisseria meningitidis Z2491 907133 YP_002342565.1 CDS NMA1167 NC_003116.1 1119382 1120416 D NMA1167, phage protein, len: 344 aa; shows weak similarity to e.g. TR:O34630 (EMBL:U83796), rstA2,Vibrio cholerae bacteriophage CTXphi protein required for replication and integration (359 aa), fasta scores; E(): 1.5e-09, 27.8% identity in 223 aa overlap. Also similar to TR:O82959 (EMBL:AB015669) ORF C7 from Burkholderia solanacearum plasmid pJTPS1 (444 aa), fasta scores; E(): 1.4e-16, 33.9% identity in 239 aa overlap. Highly similar to others from Neisseria meningitidis, NMA1999, E(): 0,100.0% identity in 344 aa overlap, NMA0782, fasta scores; E(): 0, 42.7% identity in 337 aa overlap, and NMA1792,fasta scores; E(): 0, 43.3% identity in 298 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1119382..1120416 Neisseria meningitidis Z2491 907136 YP_002342566.1 CDS NMA1168 NC_003116.1 1120407 1120751 D NMA1168, len: 114 aa; unknown, similar to others from Neisseria meningitidis, NMA2000, fasta scores; E(): 0, 100.0% identity in 114 aa overlap, NMA1793, fasta scores; E(): 1.6e-13, 37.8% identity in 98 aa overlap and NMA0781, fasta scores; E(): 2.3e-10, 34.9% identity in 83 aa overlap; hypothetical protein 1120407..1120751 Neisseria meningitidis Z2491 907137 YP_002342567.1 CDS NMA1169 NC_003116.1 1120756 1120953 D NMA1169, len: 65 aa; unknown, similar to others from Neisseria meningitidis, NMA2001, fasta scores; E(): 4.2e-27, 100.0% identity in 65 aa overlap, NMA1794, fasta scores; E(): 4.6e-07, 38.3% identity in 60 aa overlap and NMA0780, fasta scores; E(): 1.3e-06, 36.1% identity in 61 aa overlap; hypothetical protein 1120756..1120953 Neisseria meningitidis Z2491 907138 YP_002342568.1 CDS NMA1170 NC_003116.1 1120961 1121245 D NMA1170, integral membrane protein, len: 94 aa; unknown, similar to others from Neisseria meningitidis, NMA2002, fasta scores; E(): 0, 100.0% identity in 94 aa overlap. Contains hydrophobic, membrane-spanning regions, NMA1170, fasta scores; E(): 0,100.0% identity in 94 aa overlap and NMA0779, fasta scores; E(): 1.5e-18, 72.2% identity in 72 aa overlap; integral membrane protein 1120961..1121245 Neisseria meningitidis Z2491 907139 YP_002342569.1 CDS NMA1171 NC_003116.1 1121252 1121530 D NMA1171, len: 92 aa; unknown, similar to others from Neisseria meningitidis, NMA2003, fasta scores; E(): 0, 100.0% identity in 92 aa overlap, NMA0778, fasta scores; (): 1.5e-25, 58.7% identity in 92 aa overlap and NMA1796, fasta scores; E(): 8.4e-09, 32.3% identity in 93 aa overlap. C-terminus is hydrophobic; hypothetical protein 1121252..1121530 Neisseria meningitidis Z2491 907140 YP_002342570.1 CDS NMA1172 NC_003116.1 1121658 1121975 D NMA1172, len: 105 aa; similar to others from Neisseria meningitidis e.g. TR:O87782 (EMBL:AJ010115) Neisseria meningitidis strain B:15:P1.16 hypothetical protein (fragment) (148 aa), fasta scores; E(): 0, 83.8% identity in 105 aa overlap. Also similar to NMA2004, fasta scores; E(): 4e-25 54.8% identity in 104 aa overlap and NMA0777, fasta scores; E(): 6.7e-16, 57.5% identity in 73 aa overlap. Lies within a region of unusually low GC content; hypothetical protein 1121658..1121975 Neisseria meningitidis Z2491 907141 YP_002342571.1 CDS NMA1173 NC_003116.1 1121917 1122357 D NMA1173, probable cell-surface protein, len: 146 aa; highly similar to the N-terminus of TR:O87783 (EMBL:AJ010115), tspB, Neisseria meningitidis strain B:15:P1.16 T-cell and B-cell antigen (partial CDS) (504 aa), fasta scores; E(): 5.9e-29, 68.2% identity in 129 aa overlap. Similar to others from Neisseria meningitidis,e.g. NMA0776, fasta scores; E(): 1.8e-23, 51.0% identity in 145 aa overlap, and NMA1797, fasta scores; E(): 1.8e-23, 51.0% identity in 145 aa overlap (both tspB genes) and NMA2005 (another cell-surface protein), fasta scores, E(): 1.2e-30, 66.2% identity in 133 aa overlap. N-terminal half has low GC content. Contains a probable N-terminal signal sequence; cell-surface protein 1121917..1122357 Neisseria meningitidis Z2491 907142 YP_002342572.1 CDS NMA1174 NC_003116.1 1122961 1123428 D NMA1174, len: 155 aa; unknown, similar, except at the N-terminus, to SW:MDAB_ECOLI (EMBL:U18656), mdaB,Escherichia coli modulator of drug activity B ( modulator of topoisomerase IV activity imparting DMP 840,adriamycin and etoposide resistance on overexpression) (193 aa), fasta scores; E(): 0, 63.7% identity in 146 aa overlap. Also similar to hypothetical proteins from bacteria and Schizosaccharomyces pombe e.g. SW:YA05_SCHPO (EMBL:Z49811), SPAC5H10.05C, Schizosaccharomyces pombe hypothetical protein (196 aa), fasta scores; E(): 0, 55.1% identity in 147 aa overlap. Identical, except at the N-terminus, to NMA0600, fasta scores; E(): 0, 99.3% identity in 147 aa overlap; hypothetical protein 1122961..1123428 Neisseria meningitidis Z2491 907143 YP_002342573.1 CDS pntB NC_003116.1 1123636 1125021 R catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase complement(1123636..1125021) Neisseria meningitidis Z2491 907144 YP_002342574.1 CDS NMA1176 NC_003116.1 1125087 1125470 R NMA1176, membrane protein, len: 127 aa; unknown, contains hydrophobic, membrane-spanning regions; hypothetical protein complement(1125087..1125470) Neisseria meningitidis Z2491 907145 YP_002342575.1 CDS pntA NC_003116.1 1125474 1127015 R forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha complement(1125474..1127015) Neisseria meningitidis Z2491 907146 YP_002342576.1 CDS NMA1179 NC_003116.1 1127305 1128138 D NMA1179, serB, probable phosphoserine phosphatase,len: 277 aa; similar, except at N-terminus, to many e.g. SW:SERB_ECOLI (EMBL:X03046), serB, Escherichia coli phosphoserine phosphatase (EC 3.1.3.3) (322 aa), fasta scores; E(): 8.4e-30, 45.7% identity in 234 aa overlap; phosphoserine phosphatase 1127305..1128138 Neisseria meningitidis Z2491 907148 YP_002342577.1 CDS purH NC_003116.1 1129591 1131183 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1129591..1131183 Neisseria meningitidis Z2491 907151 YP_002342578.1 CDS NMA1185 NC_003116.1 1131796 1132752 D NMA1185, probable transposase, len: 318 aa; similar to many e.g. TR:Q51474 (EMBL:M24471) Alteromonas atlantica CDS within insertion element IS492 which is involved in reversible inactivation of extracellular polysaccharide production (318 aa), fasta scores; E(): 1.3e-28, 33.9% identity in 301 aa overlap. Also shows weak similarity to pilin-inverting genes e.g. SW:PIV_MORLA (EMBL:M34367),piv, Moraxella lacunata pilin gene inverting protein (322 aa), fasta scores; E(): 8.5e-14, 30.4% identity in 313 aa overlap. Highly similar to others from Neisseria meningitidis e.g. NMA0733, fasta scores; E(): 0, 94.3% identity in 279 aa overlap, also NMA2085. Contains Pfam match to entry PF01548 Transposase_9, Transposase; transposase 1131796..1132752 Neisseria meningitidis Z2491 907153 YP_002342579.1 CDS NMA1186 NC_003116.1 1132848 1133342 D NMA1186, len: 164 aa; unknown, similar to part of TR:Q38494 (EMBL:M64097) bacteriophage Mu protein E16 (195 aa), fasta scores; E(): 2.7e-05, 46.7% identity in 60 aa overlap. Identical to NMA1301 and similar to NMA1867,fasta scores; E(): 1.5e-25, 55.5% identity in 137 aa overlap; hypothetical protein 1132848..1133342 Neisseria meningitidis Z2491 907154 YP_002342580.1 CDS NMA1187 NC_003116.1 1133323 1133751 D NMA1187, len: 142 aa; unknown, identical to NMA1302 and similar to NMA1866, fasta scores; E(): 2.4e-10, 29.7% identity in 145 aa overlap; hypothetical protein 1133323..1133751 Neisseria meningitidis Z2491 907155 YP_002342581.1 CDS NMA1188 NC_003116.1 1134059 1134604 D NMA1188, amidase, len: 181 aa; shows very weak similarity to TR:P89923 (EMBL:Y11476), ply12,Bacteriophage 12826 N-acetylmuramoyl-L-alanine amidase endolysin (EC 3.5.1.28) (257 aa), fasta scores; E(): 0.16,26.0% identity in 177 aa overlap and to bacterial amidases (some ) e.g. TR:O32421 (EMBL:D76414), lytH,Staphylococcus aureus N-acetylmuramoyl-L-alanine amidase (291 aa), fasta scores; E(): 0.0093, 25.8% identity in 182 aa overlap. Identical to NMA1303 and highly similar to NMA1865, fasta scores, E(): 0, 96.7% identity in 181 aa overlap; amidase 1134059..1134604 Neisseria meningitidis Z2491 907156 YP_002342582.1 CDS NMA1189 NC_003116.1 1134810 1134974 D NMA1189, len: 54 aa; unknown, identical to NMA1304 and NMA1863; hypothetical protein 1134810..1134974 Neisseria meningitidis Z2491 907157 YP_002342583.1 CDS NMA1190 NC_003116.1 1134977 1135213 D NMA1190, len: 78 aa; unknown, identical to NMA1305 and NMA1862; hypothetical protein 1134977..1135213 Neisseria meningitidis Z2491 907158 YP_002342584.1 CDS NMA1191 NC_003116.1 1135185 1135604 D NMA1191, len: 139 aa; unknown, highly similar to NMA1306, fasta scores; E(): 0, 97.1% identity in 139 aa overlap and NMA1861, fasta scores; E(): 0, 97.1% identity in 139 aa overlap; hypothetical protein 1135185..1135604 Neisseria meningitidis Z2491 907159 YP_002342585.1 CDS NMA1192 NC_003116.1 1135624 1135806 D NMA1192, len: 60 aa; unknown, highly similar to NMA1860, fasta scores; E(): 7.9e-26, 98.3% identity in 60 aa overlap and to part of NMA1307, fasta scores; E(): 6.8e-09, 82.8% identity in 29 aa overlap; hypothetical protein 1135624..1135806 Neisseria meningitidis Z2491 907160 YP_002342586.1 CDS NMA1193 NC_003116.1 1135851 1136021 R NMA1193, len: 56 aa; unknown, identical to NMA1859; hypothetical protein complement(1135851..1136021) Neisseria meningitidis Z2491 907161 YP_002342587.1 CDS NMA1194 NC_003116.1 1136034 1136252 D NMA1194, len: 72 aa; unknown, identical to NMA1858; hypothetical protein 1136034..1136252 Neisseria meningitidis Z2491 907162 YP_002342588.1 CDS NMA1195 NC_003116.1 1136249 1136587 D NMA1195, len: 112 aa; unknown, highly similar to part of NMA1308, fasta scores; E(): 2e-20, 84.4% identity in 64 aa overlap and similar to part of NMA1857, fasta scores; E(): 7.2e-17, 47.3% identity in 112 aa overlap; hypothetical protein 1136249..1136587 Neisseria meningitidis Z2491 907163 YP_002342589.1 CDS NMA1196 NC_003116.1 1136599 1136865 D NMA1196, len: 88 aa; unknown, highly similar to NMA1310, fasta scores; E(): 6.8e-34, 94.3% identity in 88 aa overlap and similar to NMA1856, fasta scores; E(): 3.5e-11, 45.2% identity in 84 aa overlap; hypothetical protein 1136599..1136865 Neisseria meningitidis Z2491 907164 YP_002342590.1 CDS NMA1197 NC_003116.1 1136862 1137059 D NMA1197, len: 65 aa; unknown, similar to NMA1311,fasta scores; E(): 8.2e-14, 56.3% identity in 64 aa overlap and NMA1855, fasta scores; E(): 3.2e-09, 45.5% identity in 66 aa overlap; hypothetical protein 1136862..1137059 Neisseria meningitidis Z2491 907165 YP_002342591.1 CDS NMA1198 NC_003116.1 1137062 1137568 D NMA1198, DNA-binding protein, len: 168 aa; highly similar to NMA1312, fasta scores; E(): 0, 73.7% identity in 167 aa overlap and NMA1854, fasta scores; E(): 0, 69.0% identity in 168 aa overlap. Contains probable helix-turn-helix motif at aa 21-42 (Score 1161, +3.14 SD); DNA-binding protein 1137062..1137568 Neisseria meningitidis Z2491 907166 YP_002342592.1 CDS NMA1199 NC_003116.1 1137892 1138899 R NMA1199, probable transposase for IS1106A3, len: 335 aa; similar to many e.g. TR:CAB44967 (EMBL:AJ242841),Neisseria meningitidis transposase for insertion sequence IS1106A3 (335 aa), fasta scores; E(): 0, 97.3% identity in 335 aa overlap; transposase for IS1106A3 complement(1137892..1138899) Neisseria meningitidis Z2491 907167 YP_002342593.1 CDS NMA1200 NC_003116.1 1139032 1140810 R NMA1200, probable surface fibril protein, len: 529 aa; similar to the N-terminal regions of TR:Q48152 (EMBL:U38617), hia, Haemophilus influenzae adhesin (1098 aa), fasta scores; E(): 0, 44.0% identity in 627 aa overlap and TR:P71401 (EMBL:U41852), hsf, Haemophilus influenzae type B surface fibril protein (2353 aa), fasta scores; E(): 0, 47.8% identity in 584 aa overlap; surface fibril protein complement(1139032..1140810) Neisseria meningitidis Z2491 907168 YP_002342594.1 CDS NMA1201 NC_003116.1 1142680 1142850 R NMA1201, probable rubredoxin, len: 56 aa; similar to many e.g. SW:RUBR_ACICA (EMBL:Z46863) Acinetobacter calcoaceticus rubredoxin involved in the hydrocarbon hydroxylating system (54 aa), fasta scores; E(): 1.6e-13,64.2% identity in 53 aa overlap. Contains Pfam match to entry PF00301 rubredoxin, Rubredoxins and PS00202 Rubredoxin signature; rubredoxin complement(1142680..1142850) Neisseria meningitidis Z2491 907169 YP_002342595.1 CDS NMA1202 NC_003116.1 1143308 1144399 R NMA1202, probable acyl-CoA dehydrogenase, len: 363 aa; shows weak similarity to many e.g. SW:IVD_HUMAN (EMBL:M34192), ivd, Homo sapiens isovaleryl-CoA dehydrogenase precursor (EC 1.3.99.10) (423 aa), fasta scores; E(): 2.7e-10, 24.0% identity in 358 aa overlap. Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase; acyl-CoA dehydrogenase complement(1143308..1144399) Neisseria meningitidis Z2491 907170 YP_002342596.1 CDS NMA1203 NC_003116.1 1144534 1145082 R NMA1203, len: 182 aa; shows weak similarity to TR:Q53427 (EMBL:S71704), mip, Legionella pneumophila macrophage infectivity potentiator protein (184 aa), fasta scores; E(): 2.9e-08, 26.9% identity in 175 aa overlap; hypothetical protein complement(1144534..1145082) Neisseria meningitidis Z2491 907171 YP_002342597.1 CDS NMA1204 NC_003116.1 1145237 1145608 R NMA1204, len: 123 aa; unknown; hypothetical protein complement(1145237..1145608) Neisseria meningitidis Z2491 907172 YP_002342598.1 CDS dld NC_003116.1 1145903 1147594 R component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase complement(1145903..1147594) Neisseria meningitidis Z2491 907173 YP_002342599.1 CDS NMA1206 NC_003116.1 1148119 1151952 D NMA1206, probable oxidoreductase, len: 1277 aa; the N-terminal half shows weak similarity to several oxidoreductases e.g. TR:Q9ZLW7 (EMBL:AE001480), glcD,Helicobacter pylori J99 glycolate oxidase (459 aa), fasta scores; E(): 1.5e-09, 24.8% identity in 455 aa overlap. The C-terminal half shows weak similarity to iron-sulphur proteins e.g. TR:O67558 (EMBL:AE000748), glpC, Aquifex aeolicus oxido/reductase iron sulfur protein (395 aa), fasta scores; E(): 5.2e-07,22.8% identity in 465 aa overlap. Contains Pfam matches to entry PF01565 FAD_binding_4, FAD binding domain and to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; oxidoreductase 1148119..1151952 Neisseria meningitidis Z2491 907174 YP_002342600.1 CDS NMA1207 NC_003116.1 1152029 1153030 D NMA1207, len: 333 aa; similar to many hypothetical proteins e.g. TR:O68273 (EMBL:AF026544) Alcaligenes eutrophus hypothetical protein (322 aa), fasta scores; E(): 0, 47.3% identity in 315 aa overlap. Also similar to SW:NIR3_RHOCA (EMBL:X72382), nifR3, Rhodobacter capsulatus nitrogen regulation protein (not stringently required for nitrogen fixation) (324 aa), fasta scores; E(): 8.1e-19,31.5% identity in 324 aa overlap. Similar to NMA1633,fasta scores; E(): 8.3e-20, 34.0% identity in 244 aa overlap. Contains Pfam match to entry PF01207 UPF0034,Uncharacterized protein family UPF0034 and PS01136 Uncharacterized protein family UPF0034 signature; hypothetical protein 1152029..1153030 Neisseria meningitidis Z2491 907175 YP_002342601.1 CDS NMA1209 NC_003116.1 1153921 1154013 R NMA1209, len: 30 aa; unknown; hypothetical protein complement(1153921..1154013) Neisseria meningitidis Z2491 907177 YP_002342602.1 CDS NMA1210 NC_003116.1 1153976 1154284 R NMA1210, len: 102 aa; unknown; hypothetical protein complement(1153976..1154284) Neisseria meningitidis Z2491 907178 YP_002342603.1 CDS NMA1211 NC_003116.1 1154336 1154851 R NMA1211, len: 171 aa; unknown; hypothetical protein complement(1154336..1154851) Neisseria meningitidis Z2491 907179 YP_002342604.1 CDS NMA1214 NC_003116.1 1155868 1155984 D NMA1214, len: 38 aa; unknown; hypothetical protein 1155868..1155984 Neisseria meningitidis Z2491 907181 YP_002342605.1 CDS NMA1215 NC_003116.1 1155997 1156170 D NMA1215, len: 57 aa; similar to parts of hypothetical proteins from bacteriophage and bacteria e.g. SW:YO14_BPHP1 (EMBL:U24159) bacteriophage HP1 hypothetical protein (133 aa), fasta scores; E(): 3e-07, 37.5% identity in 56 aa overlap; hypothetical protein 1155997..1156170 Neisseria meningitidis Z2491 907182 YP_002342606.1 CDS NMA1216 NC_003116.1 1156173 1156388 D NMA1216, len: 71 aa; unknown; hypothetical protein 1156173..1156388 Neisseria meningitidis Z2491 907185 YP_002342607.1 CDS NMA1217 NC_003116.1 1156480 1157364 D NMA1217, probable transposase for IS1106A3, len: 294 aa; highly similar to many e.g. TR:CAB44967 (EMBL:AJ242841) Neisseria meningitidis transposase for insertion sequence IS1106A3 (335 aa), fasta scores; E(): 0, 79.4% identity in 335 aa overlap. The difference in length with respect to TR:CAB44967 is accounted for by a deletion from within the C-terminal region of NMA1217; transposase for IS1106A3 1156480..1157364 Neisseria meningitidis Z2491 907190 YP_002342608.1 CDS NMA1221 NC_003116.1 1158446 1159021 R NMA1221, phage integrase, len: 191 aa; similar to the C-terminal half of phage integrases e.g. SW:INTA_ECOLI (EMBL:U03737), intA, Escherichia coli prophage CP4-57 integrase (413 aa), fasta scores; E(): 3.1e-06, 30.3% identity in 165 aa overlap; phage integrase complement(1158446..1159021) Neisseria meningitidis Z2491 907196 YP_002342609.1 CDS NMA1222 NC_003116.1 1159330 1160205 R NMA1222, len: 291 aa; unknown; hypothetical protein complement(1159330..1160205) Neisseria meningitidis Z2491 907197 YP_002342610.1 CDS NMA1223 NC_003116.1 1160250 1160540 R NMA1223, len: 96 aa; unknown; hypothetical protein complement(1160250..1160540) Neisseria meningitidis Z2491 907198 YP_002342611.1 CDS NMA1225 NC_003116.1 1160845 1161222 D NMA1225, phage repressor, len: 125 aa; shows weak similarity to SW:RPC_BPPH1 (EMBL:X02799) Bacteriophage phi-105 immunity repressor protein (144 aa),fasta scores; E(): 0.0068, 36.3% identity in 80 aa overlap and to phage repressors. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and probable helix-turn-helix motif at aa 21-42 (Score 1857, +5.51 SD). Lies within a region of unusually low GC content; phage repressor 1160845..1161222 Neisseria meningitidis Z2491 907200 YP_002342612.1 CDS NMA1226 NC_003116.1 1161251 1161496 D NMA1226, len: 81 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1161251..1161496 Neisseria meningitidis Z2491 907201 YP_002342613.1 CDS NMA1227 NC_003116.1 1161582 1161674 D NMA1227, len: 30 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1161582..1161674 Neisseria meningitidis Z2491 907202 YP_002342614.1 CDS NMA1228 NC_003116.1 1161730 1162698 D NMA1228, len: 322 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1161730..1162698 Neisseria meningitidis Z2491 907203 YP_002342615.1 CDS NMA1229 NC_003116.1 1162695 1163177 D NMA1229, membrane protein, len: 160 aa; unknown, contains a N-terminal signal sequence and hydrophobic, membrane-spanning regions. Lies within a region of unusually low GC content; hypothetical protein 1162695..1163177 Neisseria meningitidis Z2491 907204 YP_002342616.1 CDS NMA1230 NC_003116.1 1163267 1163770 D NMA1230, len: 167 aa; unknown; hypothetical protein 1163267..1163770 Neisseria meningitidis Z2491 907205 YP_002342617.1 CDS NMA1233 NC_003116.1 1164210 1164620 D NMA1233, len: 136 aa; similar to part of TR:Q50995 (EMBL:L36381) Neisseria gonorrhoeae hypothetical protein (172 aa), fasta scores; E(): 9.1e-15, 61.2% identity in 98 aa overlap; hypothetical protein 1164210..1164620 Neisseria meningitidis Z2491 907208 YP_002342618.1 CDS NMA1234 NC_003116.1 1164625 1165374 D NMA1234, transposase, len: 249 aa; similar to many e.g. SW:T150_ECOLI (EMBL:X07037) Escherichia coli transposase for insertion sequence IS150 (283 aa), fasta scores; E(): 0, 43.7% identity in 263 aa overlap. Also highly similar to TR:Q50996 (EMBL:L36381) Neisseria gonorrhoeae hypothetical protein (267 aa), fasta scores; E(): 0, 73.4% identity in 267 aa overlap; transposase 1164625..1165374 Neisseria meningitidis Z2491 907209 YP_002342619.1 CDS NMA1237 NC_003116.1 1166120 1166725 R NMA1237, len: 201 aa; similar to bacterial hypothetical proteins e.g. SW:YFCN_ECOLI (EMBL:AE000321),yfcN, Escherichia coli hypothetical protein (183 aa),fasta scores; E(): 3.1e-06, 27.5% identity in 178 aa overlap; hypothetical protein complement(1166120..1166725) Neisseria meningitidis Z2491 907210 YP_002342620.1 CDS NMA1243 NC_003116.1 1169774 1170829 R NMA1243, probable sulphate-binding protein, len: 351 aa; similar to many e.g. SW:SUBI_ECOLI (EMBL:X02519),sbp, Escherichia coli sulfate-binding protein precursor (329 aa), fasta scores; E(): 0, 49.1% identity in 316 aa overlap. Contains Pfam match to entry PF01100 Sulphate_bind, Prokaryotic sulphate- and thiosulphate-binding protein and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; sulfate-binding protein complement(1169774..1170829) Neisseria meningitidis Z2491 907213 YP_002342621.1 CDS NMA1244 NC_003116.1 1170935 1171417 R NMA1244, len: 160 aa; similar to TR:P72792 (EMBL:D90900) Synechocystis sp. (strain PCC 6803) hypothetical protein (160 aa), fasta scores; E(): 1.1e-05,28.8% identity in 160 aa overlap. Shows very weak similarity (not statistically significant) to eukaryotic acetyltransferases e.g. SW:ATDA_MOUSE (EMBL:L10244), sat,Mus musculus diamine acetyltransferase (EC 2.3.1.57) (171 aa), fasta scores; E(): 1, 24.8% identity in 137 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; hypothetical protein complement(1170935..1171417) Neisseria meningitidis Z2491 907214 YP_002342622.1 CDS purK NC_003116.1 1171464 1172600 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(1171464..1172600) Neisseria meningitidis Z2491 907215 YP_002342623.1 CDS NMA1246 NC_003116.1 1172597 1173142 R NMA1246, len: 181 aa; unknown, previously sequenced from Neisseria meningitidis Z2491 as TR:CAB44974 (EMBL:AJ242841). Lies within a region of unusually low GC content; hypothetical protein complement(1172597..1173142) Neisseria meningitidis Z2491 907216 YP_002342624.1 CDS trpE NC_003116.1 1173139 1174614 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1173139..1174614) Neisseria meningitidis Z2491 907217 YP_002342625.1 CDS NMA1248 NC_003116.1 1174725 1175090 R NMA1248, periplasmic protein, len: 121 aa; previously sequenced from Neisseria meningitidis Z2491 as TR:CAB44972 (EMBL:AJ242841). Contains N-terminal signal sequence; hypothetical protein complement(1174725..1175090) Neisseria meningitidis Z2491 907482 YP_002342626.1 CDS NMA1249 NC_003116.1 1175111 1177021 R NMA1249, abcZ, probable ABC transporter ATP-binding protein, len: 636 aa; previously sequenced from Neisseria meningitidis Z2491 as TR:CAB44971 (EMBL:AJ242841). Similar to many e.g. SW:TLRC_STRFR (EMBL:M57437), tlrC,Streptomyces fradiae tylosin resistance ATP-binding protein (548 aa), blastp score; Expect = 1.5e-53 and SW:UUP_ECOLI (EMBL:AE000197), uup, Escherichia coli ABC transporter ATP-binding protein (635 aa),fasta scores; E(): 0, 47.2% identity in 634 aa overlap. . Similar to many others in Neisseria meningitidis,particularly NMA2101, fasta scores; E(): 0, 39.3% identity in 539 aa overlap. Contains two Pfam matches to entry PF00005 ABC_tran, ABC transporter, two PS00211 ABC transporters family signature and two PS00017 ATP/GTP-binding site motif A (P-loop); ABC transporter ATP-binding protein complement(1175111..1177021) Neisseria meningitidis Z2491 907550 YP_002342627.1 CDS NMA1250 NC_003116.1 1177040 1177684 R NMA1250, dedA, hypothetical protein, len: 214 aa; previously sequenced from Neisseria meningitidis Z2491 as TR:CAB44970 (EMBL:AJ242841), but with a different predicted start codon. Similar to many e.g. SW:DEDA_ECOLI (EMBL:M68934), dedA, Escherichia coli dedA protein Ded A protein (219 aa), fasta scores; E(): 0, 68.0% identity in 206 aa overlap. Contains Pfam match to entry PF00597 DedA,DedA family; DedA protein NMB_orthologue complement(1177040..1177684) Neisseria meningitidis Z2491 907554 YP_002342628.1 CDS NMA1251 NC_003116.1 1177848 1178666 R NMA1251, opcA, outer membrane protein precursor,len: 272 aa; previously sequenced from Neisseria meningitidis Z2491 as TR:CAB44969 (EMBL:AJ242841). C-terminus is similar to NMA2183, fasta scores; E(): 1e-05, 29.2% identity in 89 aa overlap. Contains an N-terminal signal sequence; outer membrane protein complement(1177848..1178666) Neisseria meningitidis Z2491 907555 YP_002342629.1 CDS NMA1253 NC_003116.1 1179979 1180986 D NMA1253, probable transposase for IS1106A3, len: 335 aa; previously sequenced as TR:CAB44967 (EMBL:AJ242841); transposase for IS1106A3 1179979..1180986 Neisseria meningitidis Z2491 907557 YP_002342630.1 CDS glyA NC_003116.1 1181711 1182961 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(1181711..1182961) Neisseria meningitidis Z2491 907570 YP_002342631.1 CDS NMA1255 NC_003116.1 1183442 1185217 R NMA1255, ggt, probable gamma-glutamyltranspeptidase, len: 591 aa; similar to many e.g. SW:GGT_BACSU (EMBL:U49358), ggt, Bacillus subtilis gamma-glutamyltranspeptidase precursor (EC 2.3.2.2) (587 aa), fasta scores; E(): 0, 38.2% identity in 573 aa overlap. Contains Pfam match to entry PF01019 G_glu_transpept, Gamma-glutamyltranspeptidase and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains a probable N-terminal signal sequence; gamma-glutamyltranspeptidase complement(1183442..1185217) Neisseria meningitidis Z2491 907578 YP_002342632.1 CDS NMA1257 NC_003116.1 1185786 1186013 D NMA1257, len: 75 aa; unknown; hypothetical protein 1185786..1186013 Neisseria meningitidis Z2491 907584 YP_002342633.1 CDS NMA1258 NC_003116.1 1185989 1186207 D NMA1258, len: 72 aa; similar to hypothetical proteins TR:Q9ZJY4 (EMBL:AE001544) Helicobacter pylori J99 hypothetical protein (76 aa), fasta scores; E(): 1.1e-06,47.0% identity in 66 aa overlap and TR:O25839 (EMBL:AE000629) Helicobacter pylori 26695 hypothetical protein (76 aa), fasta scores; E(): 1.3e-06, 45.5% identity in 66 aa overlap; hypothetical protein 1185989..1186207 Neisseria meningitidis Z2491 907596 YP_002342634.1 CDS fbp NC_003116.1 1186366 1187340 R catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase complement(1186366..1187340) Neisseria meningitidis Z2491 907597 YP_002342635.1 CDS NMA1260 NC_003116.1 1187586 1188431 R NMA1260, len: 281 aa; unknown, similar to SW:YHIR_ECOLI (EMBL:U00039), yhiR, Escherichia coli hypothetical protein (280 aa), fasta scores; E(): 0, 42.3% identity in 274 aa overlap and SW:YHIR_HAEIN (EMBL:M62809), HI0441, Haemophilus influenzae hypothetical protein (281 aa), fasta scores; E(): 0, 41.9% identity in 272 aa overlap; hypothetical protein complement(1187586..1188431) Neisseria meningitidis Z2491 907675 YP_002342636.1 CDS NMA1261 NC_003116.1 1188519 1189121 R NMA1261, integral membrane protein, len: 200 aa; similar to many bacterial hypothetical proteins e.g. SW:YGIH_ECOLI (EMBL:U28379), ygiH, Escherichia coli hypothetical protein (205 aa), fasta scores; E(): 7.8e-26,43.5% identity in 193 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein complement(1188519..1189121) Neisseria meningitidis Z2491 907676 YP_002342637.1 CDS NMA1262 NC_003116.1 1189177 1189533 D NMA1262, folB, probable dihydroneopterin aldolase,len: 118 aa; similar to many e.g. SW:FOLB_BACSU (EMBL:M34053), folB, Bacillus subtilis dihydroneopterin aldolase (EC 4.1.2.25) (120 aa), fasta scores; E(): 3.5e-07, 35.3% identity in 119 aa overlap and SW:FOLB_ECOLI (EMBL:U28379), folB, Escherichia coli probable dihydroneopterin aldolase (122 aa), fasta scores; E(): 9.2e-15, 40.0% identity in 115 aa overlap; dihydroneopterin aldolase 1189177..1189533 Neisseria meningitidis Z2491 907677 YP_002342638.1 CDS NMA1263 NC_003116.1 1189567 1190103 D NMA1263, len: 178 aa; unknown, similar to many bacterial hypothetical proteins e.g. SW:YQKG_BACSU (EMBL:D84432), yqkG, Bacillus subtilis hypothetical protein (185 aa), fasta scores; E(): 6.9e-21, 37.9% identity in 177 aa overlap. Contains Pfam match to entry PF00293 mutT, Bacterial mutT protein; hypothetical protein 1189567..1190103 Neisseria meningitidis Z2491 907678 YP_002342639.1 CDS NMA1264 NC_003116.1 1190759 1191118 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1190759..1191118) Neisseria meningitidis Z2491 907679 YP_002342640.1 CDS NMA1265 NC_003116.1 1191147 1191827 R NMA1265, probable integral membrane protein, len: 226 aa; unknown, contains hydrophobic, probable membrane-spanning regions; integral membrane protein complement(1191147..1191827) Neisseria meningitidis Z2491 907680 YP_002342641.1 CDS NMA1266 NC_003116.1 1191992 1195036 D NMA1266, cell-division protein, len: 1014 aa; similar to many e.g. SW:FTSK_ECOLI (EMBL:Z49932),ftsK, Escherichia coli cell division protein (1329 aa),fasta scores; E(): 0, 40.0% identity in 1015 aa overlap,the E.coli protein being approx. 300 aa longer at the N-terminus. Note that this means most of the predicted membrane spans in the E.coli homologue are absent from this protein. Similar over the C-terminal approx. 500 aa to NMA1527, fasta scores; E(): 0, 57.9% identity in 556 aa overlap. Contains Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family and PS00017 ATP/GTP-binding site motif A (P-loop). Contains a probable N-terminal signal sequence and a hydrophobic, probable membrane-spanning region; cell-division protein 1191992..1195036 Neisseria meningitidis Z2491 907681 YP_002342642.1 CDS proA NC_003116.1 1195261 1196523 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(1195261..1196523) Neisseria meningitidis Z2491 907682 YP_002342643.1 CDS proB NC_003116.1 1196536 1197645 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(1196536..1197645) Neisseria meningitidis Z2491 907683 YP_002342644.1 CDS leuA NC_003116.1 1198131 1199684 D catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 1198131..1199684 Neisseria meningitidis Z2491 907684 YP_002342645.1 CDS NMA1272 NC_003116.1 1199884 1200546 D NMA1272, len: 220 aa; unknown, shows weak similarity to SW:YECA_ECOLI (EMBL:AE000284), yecA,Escherichia coli hypothetical protein (221 aa), fasta scores; E(): 5.5e-12, 27.2% identity in 228 aa overlap; hypothetical protein 1199884..1200546 Neisseria meningitidis Z2491 907685 YP_002342646.1 CDS lgt NC_003116.1 1200629 1201480 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(1200629..1201480) Neisseria meningitidis Z2491 907686 YP_002342647.1 CDS NMA1274 NC_003116.1 1201551 1202681 R NMA1274, len: 376 aa; unknown, similar to SW:YPG2_ZYMMO (EMBL:L09649), zm2, Zymomonas mobilis hypothetical protein (380 aa), fasta scores; E(): 0, 47.1% identity in 374 aa overlap. Also similar to parts of Caenorhabditis elegans hypothetical proteins e.g. TR:O76373 (EMBL:AF067618), F56H1.5, Caenorhabditis elegans hypothetical protein (1192 aa), fasta scores; E(): 5e-11,27.1% identity in 317 aa overlap. Contains Pfam match to entry PF00246 Zn_carbOpept, Zinc carboxypeptidase; hypothetical protein complement(1201551..1202681) Neisseria meningitidis Z2491 907687 YP_002342648.1 CDS argB NC_003116.1 1202851 1203747 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1202851..1203747 Neisseria meningitidis Z2491 907688 YP_002342649.1 CDS NMA1278 NC_003116.1 1205184 1205852 R NMA1278, len: 222 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:O33611 (EMBL:AB004855) Streptomyces cyaneus protein possibly involved in morphological differentiation (277 aa), fasta scores; E(): 1.5e-15, 29.1% identity in 227 aa overlap and TR:O69629 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical protein (287 aa), fasta scores; E(): 2.1e-15, 30.2% identity in 222 aa overlap; hypothetical protein complement(1205184..1205852) Neisseria meningitidis Z2491 907690 YP_002342650.1 CDS NMA1279 NC_003116.1 1205849 1206580 R NMA1279, len: 243 aa; similar to SW:YFGE_ECOLI (EMBL:AE000336), yfgE, Escherichia coli hypothetical protein (248 aa), fasta scores; E(): 3.2e-19, 31.3% identity in 230 aa overlap and SW:YFGE_HAEIN (EMBL:U32802), HI1225.1, Haemophilus influenzae hypothetical protein (231 aa), fasta scores; E(): 5.8e-17,30.1% identity in 226 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop), which may be fortuitous; DnaA regulatory inactivator Hda complement(1205849..1206580) Neisseria meningitidis Z2491 907691 YP_002342651.1 CDS NMA1281 NC_003116.1 1207416 1207601 D NMA1281, len: 61 aa; unknown; hypothetical protein 1207416..1207601 Neisseria meningitidis Z2491 907693 YP_002342652.1 CDS NMA1282 NC_003116.1 1207797 1208678 R NMA1282, DNA-binding protein, len: 293 aa; unknown, contains probable helix-turn-helix at aa 42-63 (Score 1152, +3.11 SD); DNA-binding protein complement(1207797..1208678) Neisseria meningitidis Z2491 907694 YP_002342653.1 CDS NMA1283 NC_003116.1 1208726 1208977 D NMA1283, len: 83 aa; unknown; hypothetical protein 1208726..1208977 Neisseria meningitidis Z2491 907695 YP_002342654.1 CDS NMA1284 NC_003116.1 1208979 1210952 D NMA1284, phage transposase, len: 657 aa; similar to TR:Q38013 (EMBL:X87627) Bacteriophage D3112 transposase A (690 aa), fasta scores; E(): 0, 34.0% identity in 623 aa overlap. Similar to NMA1882, fasta scores; E(): 0, 41.3% identity in 656 aa overlap. Contains Pfam match to entry PF00552 integrase, Integrase and PS00017 ATP/GTP-binding site motif A (P-loop); phage transposase 1208979..1210952 Neisseria meningitidis Z2491 907696 YP_002342655.1 CDS NMA1287 NC_003116.1 1212171 1212437 D NMA1287, len: 88 aa; unknown, similar to part of NMA1880, fasta scores; E(): 0.0086, 36.5% identity in 63 aa overlap; hypothetical protein 1212171..1212437 Neisseria meningitidis Z2491 907699 YP_002342656.1 CDS NMA1288 NC_003116.1 1212430 1212549 D NMA1288, len: 39 aa; unknown; hypothetical protein 1212430..1212549 Neisseria meningitidis Z2491 907701 YP_002342657.1 CDS NMA1289 NC_003116.1 1212698 1212820 D NMA1289, len: 40 aa; unknown; hypothetical protein 1212698..1212820 Neisseria meningitidis Z2491 907702 YP_002342658.1 CDS NMA1290 NC_003116.1 1212900 1213067 D NMA1290, len: 55 aa; unknown; hypothetical protein 1212900..1213067 Neisseria meningitidis Z2491 907703 YP_002342659.1 CDS NMA1291 NC_003116.1 1213177 1213695 D NMA1291, gam, probable host-nuclease inhibitor protein, len: 172 aa; similar to several e.g. SW:VGAM_BPMU (EMBL:X04390), gam, Bacteriophage Mu host-nuclease inhibitor protein (174 aa), fasta scores; E(): 3.9e-24,46.8% identity in 173 aa overlap; host-nuclease inhibitor protein 1213177..1213695 Neisseria meningitidis Z2491 907704 YP_002342660.1 CDS NMA1292 NC_003116.1 1213855 1214070 R NMA1292, len: 71 aa; unknown; hypothetical protein complement(1213855..1214070) Neisseria meningitidis Z2491 907705 YP_002342661.1 CDS NMA1293 NC_003116.1 1214074 1214682 R NMA1293, phage anti-repressor protein,len: 202 aa; similar to several e.g. TR:Q38585 (EMBL:X95646), ant, Streptococcus thermophilus bacteriophage Sfi21 anti-repressor protein (287 aa), fasta scores; E(): 6.5e-07, 31.3% identity in 134 aa overlap and TR:AAD25485 (EMBL:AF125520), L0142, bacteriophage 933W hypothetical protein (209 aa), fasta scores; E(): 2.7e-17,37.8% identity in 201 aa overlap; phage anti-repressor protein complement(1214074..1214682) Neisseria meningitidis Z2491 907706 YP_002342662.1 CDS NMA1294 NC_003116.1 1214814 1215014 R NMA1294, len: 66 aa; unknown, similar to NMA1297,fasta scores; E(): 1.4e-08, 43.9% identity in 57 aa overlap and NMA1295, fasta scores; E(): 7.1e-07, 51.1% identity in 47 aa overlap; hypothetical protein complement(1214814..1215014) Neisseria meningitidis Z2491 907707 YP_002342663.1 CDS NMA1295 NC_003116.1 1215215 1215400 R NMA1295, len: 61 aa; unknown, similar to NMA1297,fasta scores; E(): 2.7e-09, 53.8% identity in 52 aa overlap and NMA1294, fasta scores; E(): 4.1e-06, 51.1% identity in 47 aa overlap; hypothetical protein complement(1215215..1215400) Neisseria meningitidis Z2491 907708 YP_002342664.1 CDS NMA1296 NC_003116.1 1215379 1215480 R NMA1296, len: 33 aa; unknown; hypothetical protein complement(1215379..1215480) Neisseria meningitidis Z2491 907709 YP_002342665.1 CDS NMA1297 NC_003116.1 1215673 1215840 R NMA1297, len: 55 aa; unknown, similar to NMA1295,fasta scores; E(): 1.9e-10, 53.8% identity in 52 aa overlap and NMA1294, fasta scores; E(): 1.1e-08, 43.9% identity in 57 aa overlap; hypothetical protein complement(1215673..1215840) Neisseria meningitidis Z2491 907710 YP_002342666.1 CDS NMA1298 NC_003116.1 1216064 1216246 D NMA1298, len: 60 aa; unknown; hypothetical protein 1216064..1216246 Neisseria meningitidis Z2491 907711 YP_002342667.1 CDS NMA1299 NC_003116.1 1216363 1216554 D NMA1299, len: 63 aa; unknown; hypothetical protein 1216363..1216554 Neisseria meningitidis Z2491 907712 YP_002342668.1 CDS NMA1300 NC_003116.1 1216551 1216967 D NMA1300, membrane protein, len: 138 aa; unknown, contains hydrophobic, membrane-spanning regions; hypothetical protein 1216551..1216967 Neisseria meningitidis Z2491 907713 YP_002342669.1 CDS NMA1301 NC_003116.1 1217082 1217576 D NMA1301, len: 164 aa; unknown, similar to part of TR:Q38494 (EMBL:M64097) bacteriophage Mu protein E16 (195 aa), fasta scores; E(): 2.7e-05, 46.7% identity in 60 aa overlap. Identical to NMA1186 and similar to NMA1867,fasta scores; E(): 1.5e-25, 55.5% identity in 137 aa overlap; hypothetical protein 1217082..1217576 Neisseria meningitidis Z2491 907714 YP_002342670.1 CDS NMA1302 NC_003116.1 1217557 1217985 D NMA1302, len: 142 aa; unknown, identical to NMA1187 and similar to NMA1866, fasta scores; E(): 1.8e-10, 29.7% identity in 145 aa overlap; hypothetical protein 1217557..1217985 Neisseria meningitidis Z2491 907715 YP_002342671.1 CDS NMA1303 NC_003116.1 1218293 1218838 D NMA1303, amidase, len: 181 aa; shows very weak similarity to TR:P89923 (EMBL:Y11476), ply12,Bacteriophage 12826 N-acetylmuramoyl-L-alanine amidase endolysin (EC 3.5.1.28) (257 aa), fasta scores; E(): 0.16,26.0% identity in 177 aa overlap and to bacterial amidases (some ) e.g. TR:O32421 (EMBL:D76414), lytH,Staphylococcus aureus N-acetylmuramoyl-L-alanine amidase (291 aa), fasta scores; E(): 0.0093, 25.8% identity in 182 aa overlap. identical to NMA1188 and highly similar to NMA1864, fasta scores; E(): 0, 96.7% identity in 181 aa overlap; amidase 1218293..1218838 Neisseria meningitidis Z2491 907716 YP_002342672.1 CDS NMA1304 NC_003116.1 1219044 1219208 D NMA1304, len: 54 aa; unknown, identical to NMA1189 and NMA1863; hypothetical protein 1219044..1219208 Neisseria meningitidis Z2491 907717 YP_002342673.1 CDS NMA1305 NC_003116.1 1219211 1219447 D NMA1305, len: 78 aa; unknown, identical to NMA1190 and NMA1862; hypothetical protein 1219211..1219447 Neisseria meningitidis Z2491 907718 YP_002342674.1 CDS NMA1306 NC_003116.1 1219419 1219838 D NMA1306, len: 139 aa; unknown, identical to NMA1861 and highly similar to NMA1191, fasta scores; E(): 0, 97.1% identity in 139 aa overlap; hypothetical protein 1219419..1219838 Neisseria meningitidis Z2491 907719 YP_002342675.1 CDS NMA1307 NC_003116.1 1219858 1220052 D NMA1307, len: 64 aa; unknown, highly similar to NMA1192, fasta scores; E(): 1.9e-11, 82.8% identity in 29 aa overlap and NMA1860, fasta scores; E(): 1.9e-11, 82.8% identity in 29 aa overlap; hypothetical protein 1219858..1220052 Neisseria meningitidis Z2491 907720 YP_002342676.1 CDS NMA1308 NC_003116.1 1220049 1220261 D NMA1308, len: 70 aa; unknown, highly similar to NMA1195, fasta scores; E(): 3.3e-24, 84.4% identity in 64 aa overlap and NMA1157, fasta scores; E(): 1.7e-11, 47.5% identity in 61 aa overlap; hypothetical protein 1220049..1220261 Neisseria meningitidis Z2491 907721 YP_002342677.1 CDS NMA1309 NC_003116.1 1220258 1220377 D NMA1309, len: 39 aa; unknown, similar to NMA1195,fasta scores; E(): 6.1e-08, 65.7% identity in 35 aa overlap and NMA1857, fasta scores; E(): 0.036, 42.9% identity in 35 aa overlap; hypothetical protein 1220258..1220377 Neisseria meningitidis Z2491 907722 YP_002342678.1 CDS NMA1310 NC_003116.1 1220389 1220655 D NMA1310, len: 88 aa; unknown, highly similar to NMA1196, fasta scores; E(): 3.9e-33, 94.3% identity in 88 aa overlap and similar to NMA1156, fasta scores; E(): 1.5e-10, 44.0% identity in 84 aa overlap; hypothetical protein 1220389..1220655 Neisseria meningitidis Z2491 907723 YP_002342679.1 CDS NMA1311 NC_003116.1 1220652 1220849 D NMA1311, len: 65 aa; unknown, similar to NMA1197,fasta scores; E(): 1.1e-14, 56.3% identity in 64 aa overlap and NMA1855, fasta scores; E(): 1.2e-10, 47.0% identity in 66 aa overlap; hypothetical protein 1220652..1220849 Neisseria meningitidis Z2491 907724 YP_002342680.1 CDS NMA1312 NC_003116.1 1220851 1221357 D NMA1312, DNA-binding protein, len: 168 aa; unknown, similar to NMA1198, fasta scores; E(): 0, 73.7% identity in 167 aa overlap and NMA1854, fasta scores; E(): 0, 56.3% identity in 167 aa overlap. Contains probable helix-turn-helix motif at aa 21-42 (Score 1051, +2.77 SD); DNA-binding protein 1220851..1221357 Neisseria meningitidis Z2491 907725 YP_002342681.1 CDS NMA1313 NC_003116.1 1221378 1223000 D NMA1313, len: 540 aa; unknown, highly similar to NMA1852, fasta scores; E(): 0, 86.5% identity in 539 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1221378..1223000 Neisseria meningitidis Z2491 907726 YP_002342682.1 CDS NMA1314 NC_003116.1 1223000 1224568 D NMA1314, len: 522 aa; unknown, similar to SW:YF01_HAEIN (EMBL:U32826), HI1501, Haemophilus influenzae hypothetical protein (520 aa), fasta scores; E(): 0, 40.2% identity in 518 aa overlap and contains a region similar to SW:YF71_HAEIN (EMBL:U32831), HI1571,Haemophilus influenzae hypothetical protein (79 aa), fasta scores; E(): 7.5e-14, 63.2% identity in 76 aa overlap. Highly similar to NMA1851, fasta scores; E(): 0, 49.0% identity in 510 aa overlap; hypothetical protein 1223000..1224568 Neisseria meningitidis Z2491 907727 YP_002342683.1 CDS NMA1315 NC_003116.1 1224555 1225850 D NMA1315, len: 431 aa; unknown, contains regions similar to SW:YF70_HAEIN (EMBL:U32831), HI1570,Haemophilus influenzae hypothetical protein (169 aa),fasta scores; E(): 4.6e-25, 48.7% identity in 154 aa overlap, SW:YF02_HAEIN (EMBL:U32827), HI1502, Haemophilus influenzae hypothetical protein (414 aa), fasta scores; E(): 3.8e-22, 35.4% identity in 237 aa overlap and TR:Q46548 (EMBL:U20249) Bacteroides nodosus plasmid pJIR787 ORF240' (fragment) (240 aa), fasta scores; E(): 4.8e-12, 30.4% identity in 194 aa overlap. Similar to NMA1850, fasta scores; E(): 0, 33.1% identity in 378 aa overlap; hypothetical protein 1224555..1225850 Neisseria meningitidis Z2491 907728 YP_002342684.1 CDS NMA1320 NC_003116.1 1228229 1229374 D NMA1320, len: 381 aa; unknown, shows weak similarity to SW:VPP_BPMU (EMBL:X06796) bacteriophage Mu tail protein (379 aa), fasta scores; E(): 1.2e-12, 24.9% identity in 366 aa overlap. Similar to NMA1830, fasta scores; E(): 0, 44.8% identity in 373 aa overlap; hypothetical protein 1228229..1229374 Neisseria meningitidis Z2491 907732 YP_002342685.1 CDS NMA1321 NC_003116.1 1229371 1230039 D NMA1321, len: 222 aa; unknown, shows weak similarity to SW:VPV_BPP2 (EMBL:AF063097) bacteriophage P2 baseplate assembly protein V (211 aa), fasta scores; E(): 0.85, 24.4% identity in 221 aa overlap and SW:YF18_HAEIN (EMBL:U32827), HI1518, Haemophilus influenzae hypothetical protein (182 aa), fasta scores; E(): 0.0011, 26.8% identity in 194 aa overlap. Similar to NMA1829, fasta scores; E(): 1.8e-32, 46.7% identity in 197 aa overlap; hypothetical protein 1229371..1230039 Neisseria meningitidis Z2491 907733 YP_002342686.1 CDS NMA1322 NC_003116.1 1230139 1230486 D NMA1322, len: 115 aa; unknown, shows weak similarity to SW:YF19_HAEIN (EMBL:U32827), HI1519,Haemophilus influenzae hypothetical protein (135 aa),fasta scores; E(): 0.031, 36.3% identity in 102 aa overlap. Similar to NMA1828, fasta scores; E(): 3.4e-20,51.3% identity in 117 aa overlap; hypothetical protein 1230139..1230486 Neisseria meningitidis Z2491 907734 YP_002342687.1 CDS NMA1323 NC_003116.1 1230500 1231555 D NMA1323, len: 351 aa; unknown, similar to bacterial hypothetical proteins including SW:XKDT_BACSU (EMBL:Z70177), xkdT, phage-like element PbsX protein (348 aa), fasta scores; E(): 1.2e-07, 28.0% identity in 361 aa overlap and SW:YF20_HAEIN (EMBL:U32827), HI1520,Haemophilus influenzae hypothetical protein (355 aa),fasta scores; E(): 4.7e-16, 31.5% identity in 321 aa overlap. Similar at the N-terminus to NMA1827, fasta scores; E(): 1.5e-18, 41.4% identity in 152 aa overlap and at the C-terminus to NMA1826, fasta scores; E(): 1e-29,50.8% identity in 185 aa overlap; hypothetical protein 1230500..1231555 Neisseria meningitidis Z2491 907735 YP_002342688.1 CDS NMA1324 NC_003116.1 1231552 1232112 D NMA1324, len: 186 aa; unknown, shows weak similarity to SW:YMFQ_ECOLI (EMBL:AE000214), ymfQ,Escherichia coli hypothetical protein (194 aa), fasta scores; E(): 0.0001, 28.2% identity in 195 aa overlap. Similar to NMA1825, fasta scores; E(): 9.6e-24, 42.4% identity in 184 aa overlap; hypothetical protein 1231552..1232112 Neisseria meningitidis Z2491 907736 YP_002342689.1 CDS NMA1325 NC_003116.1 1232123 1234096 D NMA1325, phage tail fibre protein, len: 657 aa; similar in part to SW:VPH_BPHP1 (EMBL:U24159) bacteriophage HP1 probable tail fibre protein (925 aa),fasta scores; E(): 0, 48.7% identity in 452 aa overlap. The N-terminus is similar to that of NMA1824, fasta scores; E(): 3.9e-09, 33.3% identity in 147 aa overlap; phage tail fiber protein 1232123..1234096 Neisseria meningitidis Z2491 907737 YP_002342690.1 CDS NMA1328 NC_003116.1 1235174 1235779 D NMA1328, len: 201 aa; unknown, C-terminal half is similar to SW:YE02_HAEIN (EMBL:U32820), HI1402,Haemophilus influenzae hypothetical protein (68 aa), fasta scores; E(): 1.3e-08, 56.3% identity in 64 aa overlap. Shows weak similarity to NMA1823, E(): 3.6e-07, 28.8% identity in 191 aa overlap; hypothetical protein 1235174..1235779 Neisseria meningitidis Z2491 907740 YP_002342691.1 CDS NMA1329 NC_003116.1 1235758 1236054 D NMA1329, len: 98 aa; unknown; hypothetical protein 1235758..1236054 Neisseria meningitidis Z2491 907741 YP_002342692.1 CDS NMA1332 NC_003116.1 1237954 1238601 R NMA1332, periplasmic protein, len: 215 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein complement(1237954..1238601) Neisseria meningitidis Z2491 907744 YP_002342693.1 CDS NMA1334 NC_003116.1 1238598 1238969 R NMA1334, periplasmic protein, len: 123 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein complement(1238598..1238969) Neisseria meningitidis Z2491 907745 YP_002342694.1 CDS NMA1335 NC_003116.1 1238976 1239647 R NMA1335, periplasmic protein, len: 223 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein complement(1238976..1239647) Neisseria meningitidis Z2491 907746 YP_002342695.1 CDS NMA1336 NC_003116.1 1239812 1240582 R NMA1336, oxidoreductase, len: 256 aa; similar to many from both bacterial and eukaryotic sources e.g. weak similarity to SW:TRN1_DATST (EMBL:L20473) Datura stramonium tropinone reductase-I (273 aa), fasta scores; E(): 7.1e-11, 30.2% identity in 205 aa overlap. Similar to SW:YCIK_ECOLI (EMBL:AE000225), yciK, Escherichia coli hypothetical oxidoreductase (252 aa), fasta scores; E(): 6.9e-25, 35.2% identity in 233 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase; short chain dehydrogenase complement(1239812..1240582) Neisseria meningitidis Z2491 907747 YP_002342696.1 CDS NMA1338 NC_003116.1 1240615 1241928 R NMA1338, oxidoreductase, len: 437 aa; shows weak similarity to phytoene dehydrogenases e.g. TR:Q40406 (EMBL:X78815), pds, Narcissus pseudonarcissus phytoene dehydrogenase precursor (570 aa), fasta scores; E(): 1.6e-06, 24.7% identity in 473 aa overlap. Also to SW:Y4AB_RHISN (EMBL:AE000064), Y4AB, Rhizobium sp. (strain NGR234) hypothetical protein (417 aa), fasta scores; E(): 8.9e-15, 27.3% identity in 444 aa overlap; oxidoreductase complement(1240615..1241928) Neisseria meningitidis Z2491 907748 YP_002342697.1 CDS NMA1339 NC_003116.1 1242009 1242881 R NMA1339, poly-isoprenyl transferase, len: 290 aa; similar to many phytoene synthases e.g. SW:PSY_CAPAN (EMBL:X68017), psy1, Capsicum annuum phytoene synthase precursor (EC 2.5.1.-) (419 aa), fasta scores; E(): 6.7e-26, 36.0% identity in 278 aa overlap (NMA1339 is shorter at the N-terminus) and TR:CAB39693 (EMBL:AL049485), SC6A5.09, Streptomyces coelicolor phytoene synthase (312 aa0, fasta scores; E(): 1.6e-32, 38.0% identity in 287 aa overlap. Similar to NMA1721, fasta scores; E(): 2e-17, 31.0% identity in 226 aa overlap. Contains Pfam match to entry PF00494 SQS_PSY,Squalene and phytoene synthases; poly-isoprenyl transferase complement(1242009..1242881) Neisseria meningitidis Z2491 907749 YP_002342698.1 CDS hscA NC_003116.1 1243052 1244914 D involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 1243052..1244914 Neisseria meningitidis Z2491 907750 YP_002342699.1 CDS NMA1341 NC_003116.1 1245237 1245800 D NMA1341, len: 187 aa; unknown; hypothetical protein 1245237..1245800 Neisseria meningitidis Z2491 907751 YP_002342700.1 CDS NMA1343 NC_003116.1 1246037 1246597 D NMA1343, len: 186 aa; unknown; hypothetical protein 1246037..1246597 Neisseria meningitidis Z2491 907752 YP_002342701.1 CDS NMA1344 NC_003116.1 1246652 1246993 D NMA1344, fdx, probable ferredoxin, len: 113 aa; similar to many e.g. SW:FER_ECOLI (EMBL:M88654), fdx,Escherichia coli ferredoxin 2FE-2S (110 aa), fasta scores; E(): 1.2e-30, 67.3% identity in 110 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains; ferredoxin 1246652..1246993 Neisseria meningitidis Z2491 907753 YP_002342702.1 CDS NMA1345 NC_003116.1 1247280 1247867 R NMA1345, len: 195 aa; unknown; hypothetical protein complement(1247280..1247867) Neisseria meningitidis Z2491 907754 YP_002342703.1 CDS NMA1347 NC_003116.1 1248080 1248277 D NMA1347, len: 65 aa; unknown, similar to bacterial hypothetical proteins e.g. TR:O69223 (EMBL:AF010139) Azotobacter vinelandii hypothetical protein (68 aa), fasta scores; E(): 2.9e-14, 56.9% identity in 65 aa overlap; hypothetical protein 1248080..1248277 Neisseria meningitidis Z2491 907755 YP_002342704.1 CDS NMA1348 NC_003116.1 1248345 1248746 R NMA1348, len: 133 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YRFH_ECOLI (EMBL:U18997),yrfH, Escherichia coli hypothetical protein (133 aa),fasta scores; E(): 1.3e-19, 45.5% identity in 132 aa overlap. Contains Pfam match to entry PF01479 S4, S4 domain; hypothetical protein complement(1248345..1248746) Neisseria meningitidis Z2491 907756 YP_002342705.1 CDS accA NC_003116.1 1248958 1249917 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 1248958..1249917 Neisseria meningitidis Z2491 907757 YP_002342706.1 CDS NMA1350 NC_003116.1 1250015 1251295 D NMA1350, len: 426 aa; unknown, similar to many bacterial hypothetical proteins e.g. SW:MESJ_ECOLI (EMBL:D49445), mesJ, Escherichia coli cell cycle protein (432 aa), fasta scores; E(): 0, 34.3% identity in 428 aa overlap; hypothetical protein 1250015..1251295 Neisseria meningitidis Z2491 907758 YP_002342707.1 CDS NMA1351 NC_003116.1 1251369 1252154 D NMA1351, RNA methyltransferase, len: 261 aa; shows weak similarity to SW:TSNR_STRLU (EMBL:L39157),tsnR, Streptomyces laurentii rRNA (adenosine-2'-O-)-methyltransferase (270 aa), fasta scores; E(): 1.4e-07, 26.1% identity in 253 aa overlap. Similar to many hypothetical proteins e.g. SW:YG73_SYNY3 (EMBL:D90913), SLR1673, Synechocystis sp. (strain PCC 6803) hypothetical tRNA/rRNA methyltransferase (274 aa),fasta scores; E(): 9e-20, 34.1% identity in 267 aa overlap. Shows weak similarity to NMA1127, fasta scores; E(): 1.3e-10, 27.7% identity in 224 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family; RNA methyltransferase 1251369..1252154 Neisseria meningitidis Z2491 907759 YP_002342708.1 CDS NMA1353 NC_003116.1 1252205 1252441 D NMA1353, lipoprotein, len: 78 aa; unknown,contains a N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, therefore may be a lipoprotein; lipoprotein 1252205..1252441 Neisseria meningitidis Z2491 907760 YP_002342709.1 CDS NMA1354 NC_003116.1 1252563 1252976 D NMA1354, len: 137 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1252563..1252976 Neisseria meningitidis Z2491 907761 YP_002342710.1 CDS NMA1355 NC_003116.1 1252988 1253293 D NMA1355, periplasmic protein, len: 101 aa; unknown, contains a N-terminal signal sequence. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1252988..1253293 Neisseria meningitidis Z2491 907762 YP_002342711.1 CDS NMA1356 NC_003116.1 1253355 1254731 D NMA1356, mpl, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso- diaminopimelate ligase, len: 458 aa; similar to SW:MPL_ECOLI (EMBL:U14003), mpl, Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso- diaminopimelate ligase (EC 6.3.2.-) (457 aa), fasta scores; E(): 0, 57.3% identity in 457 aa overlap. Shows weak similarity to NMA2061, fasta scores; E(): 1.5e-19, 28.4% identity in 479 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 1253355..1254731 Neisseria meningitidis Z2491 907763 YP_002342712.1 CDS NMA1358 NC_003116.1 1254938 1255990 D NMA1358, bioB, probable biotin synthase, len: 350 aa; similar to many e.g. SW:BIOB_ECOLI (EMBL:J04423),bioB, Escherichia coli biotin synthase (EC 2.8.1.6) (346 aa), fasta scores; E(): 0, 59.1% identity in 308 aa overlap; biotin synthase 1254938..1255990 Neisseria meningitidis Z2491 907765 YP_002342713.1 CDS NMA1359 NC_003116.1 1256068 1256703 R NMA1359, len: 211 aa; unknown; hypothetical protein complement(1256068..1256703) Neisseria meningitidis Z2491 907766 YP_002342714.1 CDS NMA1360 NC_003116.1 1256827 1257066 R NMA1360, len: 79 aa; unknown; hypothetical protein complement(1256827..1257066) Neisseria meningitidis Z2491 907767 YP_002342715.1 CDS ilvD NC_003116.1 1257349 1259208 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(1257349..1259208) Neisseria meningitidis Z2491 907768 YP_002342716.1 CDS cysI NC_003116.1 1259381 1261150 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(1259381..1261150) Neisseria meningitidis Z2491 907769 YP_002342717.1 CDS NMA1363 NC_003116.1 1261177 1262991 R NMA1363, cysJ, probable sulphite reductase alpha subunit, len: 604 aa; similar to many e.g. SW:CYSJ_ECOLI (EMBL:M23008), cysJ, Escherichia coli sulfite reductase [NADPH] flavoprotein alpha-component (EC 1.8.1.2) (598 aa), fasta scores; E(): 0, 55.7% identity in 600 aa overlap. Contains Pfam matches to entry PF00667 FAD_binding, FAD binding domain and to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain; sulfite reductase subunit alpha complement(1261177..1262991) Neisseria meningitidis Z2491 907770 YP_002342718.1 CDS NMA1364 NC_003116.1 1262988 1264274 R NMA1364, cysN, probable sulphate adenylate transferase subunit 1, len: 428 aa; similar to many e.g. SW:CYSN_ECOLI (EMBL:M74586), cysN, Escherichia coli sulfate adenylate transferase subunit 1 (EC 2.7.7.4) (475 aa), fasta scores; E(): 0, 46.8% identity in 432 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU,Elongation factor Tu family, PS00301 GTP-binding elongation factors signature and PS00017 ATP/GTP-binding site motif A (P-loop); sulfate adenylate transferase subunit 1 complement(1262988..1264274) Neisseria meningitidis Z2491 907771 YP_002342719.1 CDS cysD NC_003116.1 1264313 1265236 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(1264313..1265236) Neisseria meningitidis Z2491 907772 YP_002342720.1 CDS cysH NC_003116.1 1265274 1266008 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(1265274..1266008) Neisseria meningitidis Z2491 907773 YP_002342721.1 CDS NMA1367 NC_003116.1 1266024 1267484 R NMA1367, cysG, sirohaem synthase, len: 486 aa; highly similar to TR:P95370 (EMBL:Y10177), cysG, Neisseria meningitidis strain MC58 sirohaem synthase (EC 2.1.1.107) (475 aa), fasta scores; E(): 0, 97.5% identity in 474 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases,PS00839 Uroporphyrin-III C-methyltransferase signature 1 and PS00840 Uroporphyrin-III C-methyltransferase signature 2; siroheme synthase complement(1266024..1267484) Neisseria meningitidis Z2491 907774 YP_002342722.1 CDS NMA1368 NC_003116.1 1267781 1268437 R NMA1368, membrane protein, len: 218 aa; similar to TR:Q46471 (EMBL:U25811) Chromatium vinosum hypothetical protein (231 aa), fasta scores; E(): 1.1e-23,37.9% identity in 211 aa overlap. Contains hydrophobic, membrane-spanning regions. C-terminus contains a poly-Ala tract; hypothetical protein complement(1267781..1268437) Neisseria meningitidis Z2491 907775 YP_002342723.1 CDS NMA1369 NC_003116.1 1268502 1269392 D NMA1369, len: 296 aa; unknown, similar to the C-terminal half of bacterial hypothetical proteins e.g. SW:YJEF_ECOLI (EMBL:U14003), yjeF, Escherichia coli hypothetical protein (515 aa), fasta scores; E(): 7.8e-28,37.8% identity in 278 aa overlap. Contains Pfam match to entry PF01256 UPF0031, Uncharacterized protein family UPF0031; hypothetical protein 1268502..1269392 Neisseria meningitidis Z2491 907776 YP_002342724.1 CDS NMA1370 NC_003116.1 1269662 1271473 D NMA1370, typA, probable GTP-binding protein, len: 603 aa; similar to many e.g. SW:TYPA_ECOLI (EMBL:L19201),typA, Escherichia coli GTP-binding protein implicated in regulation of virulence factors, fasta scores; E(): 0,64.1% identity in 599 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family,PS00301 GTP-binding elongation factors signature and PS00017 ATP/GTP-binding site motif A (P-loop); GTP-binding protein 1269662..1271473 Neisseria meningitidis Z2491 907777 YP_002342725.1 CDS NMA1371 NC_003116.1 1272463 1274838 D NMA1371, vacB, probable ribonuclease, len: 791 aa; similar to many e.g. SW:VACB_SHIFL (EMBL:D11024), vacB,Shigella flexneri chromosomal gene required for expression of virulence genes (also in enteroinvasive Escherichia coli) (760 aa), fasta scores; E(): 0, 44.9% identity in 762 aa overlap. May have a post-transcriptional regulatory role. Also similar to SW:RNB_ECOLI (EMBL:X67913), rnb,Escherichia coli exoribonuclease II (EC 3.1.13.1) (644 aa), fasta scores; E(): 0, 30.0% identity in 580 aa overlap. Contains Pfam matches to entry PF00773 RNB,RNB-like proteins and to entry PF00575 S1, S1 RNA binding domain and PS01175 Ribonuclease II family signature; ribonuclease 1272463..1274838 Neisseria meningitidis Z2491 907778 YP_002342726.1 CDS guaB NC_003116.1 1275177 1276640 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(1275177..1276640) Neisseria meningitidis Z2491 907779 YP_002342727.1 CDS NMA1373 NC_003116.1 1276967 1277428 R NMA1373, len: 153 aa; unknown; hypothetical protein complement(1276967..1277428) Neisseria meningitidis Z2491 907780 YP_002342728.1 CDS NMA1374 NC_003116.1 1277519 1280077 R NMA1374, glnD, probable [protein-PII] uridylyltransferase, len: 852 aa; similar to many e.g. SW:GLND_ECOLI (EMBL:M96431), glnD, Escherichia coli [protein-PII] uridylyltransferase (EC 2.7.7.59) (890 aa),fasta scores; E(): 0, 33.1% identity in 865 aa overlap; [protein-PII] uridylyltransferase complement(1277519..1280077) Neisseria meningitidis Z2491 907781 YP_002342729.1 CDS NMA1375 NC_003116.1 1280126 1280446 R NMA1375, transcriptional regulator, len: 106 aa; similar to e.g. regulatory proteins of restriction modification systems e.g. TR:Q52622 (EMBL:M77223), pvuIIC,Proteus vulgaris regulatory transcription factor C (84 aa), fasta scores; E(): 1.8e-05, 42.2% identity in 64 aa overlap. Similar to TR:AAD39136 (EMBL:AF123569), nmeSIC,Neisseria meningitidis strain 800615 (serotype B:4:P1.4) control element (70 aa), fasta scores; E(): 4.3e-05, 46.0% identity in 50 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. Contains a probable helix-turn-helix motif at aa 36-57 (Score 1818,+5.38 SD); transcriptional regulator complement(1280126..1280446) Neisseria meningitidis Z2491 907782 YP_002342730.1 CDS NMA1376 NC_003116.1 1280770 1281243 R NMA1376, bfrB, probable bacterioferritin B, len: 157 aa; similar to many e.g. SW:BFRB_NEIGO (EMBL:U76634),bfrB, Neisseria gonorrhoeae bacterioferritin B (157 aa),fasta scores; E(): 0, 99.4% identity in 157 aa overlap and SW:BFR_AZOVI (EMBL:M83692), bfr, Azotobacter vinelandii bacterioferritin (156 aa), fasta scores; E(): 0, 62.2% identity in 156 aa overlap. Similar to NMA1377, fasta scores; E(): 3.1e-17, 39.9% identity in 153 aa overlap; bacterioferritin B complement(1280770..1281243) Neisseria meningitidis Z2491 907783 YP_002342731.1 CDS NMA1377 NC_003116.1 1281271 1281735 R NMA1377, bfrA, probable bacterioferritin A, len: 154 aa; similar to many e.g. SW:BFRA_NEIGO (EMBL:U76633),bfrA, Neisseria gonorrhoeae bacterioferritin A (154 aa),fasta scores; E(): 0, 99.4% identity in 154 aa overlap and SW:BFR_PSEPU (EMBL:U66717), bfr, Pseudomonas putida bacterioferritin (154 aa), fasta scores; E(): 0, 61.0% identity in 154 aa overlap. Similar to NMA1376, fasta scores; E(): 2.2e-17, 39.9% identity in 153 aa overlap; bacterioferritin A complement(1281271..1281735) Neisseria meningitidis Z2491 907784 YP_002342732.1 CDS lipA NC_003116.1 1282199 1283182 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(1282199..1283182) Neisseria meningitidis Z2491 907785 YP_002342733.1 CDS lipB NC_003116.1 1283175 1283747 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(1283175..1283747) Neisseria meningitidis Z2491 907786 YP_002342734.1 CDS NMA1380 NC_003116.1 1283800 1284075 R NMA1380, len: 91 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YBED_ECOLI (EMBL:L07636),ybeD, Escherichia coli hypothetical protein (87 aa),fasta scores; E(): 3.1e-08, 37.8% identity in 82 aa overlap; hypothetical protein complement(1283800..1284075) Neisseria meningitidis Z2491 907787 YP_002342735.1 CDS NMA1381 NC_003116.1 1284260 1285330 D NMA1381, probable integral membrane protein, len: 356 aa; similar to many bacterial hypothetical proteins e.g. SW:PERM_ECOLI (EMBL:AE000335), perm, Escherichia coli permease (353 aa), fasta scores; E(): 1.5e-19,26.2% identity in 313 aa overlap. Contains Pfam match to entry PF01594 DUF20, permease. Contains hydrophobic, probable membrane-spanning regions; integral membrane protein 1284260..1285330 Neisseria meningitidis Z2491 907788 YP_002342736.1 CDS NMA1382 NC_003116.1 1285437 1286384 R NMA1382, periplasmic protein, len: 315 aa; similar to many hypothetical proteins found in both bacteria and eukaryotes e.g. TR:O60376 (EMBL:AC004472),P1.11659_4, Homo sapiens hypothetical protein (357 aa),fasta scores; E(): 0, 48.4% identity in 289 aa overlap and TR:Q9ZDK0 (EMBL:AJ235271), RP328, Rickettsia prowazekii hypothetical protein (311 aa), fasta scores; E(): 0, 48.6% identity in 315 aa overlap. Contains Pfam match to entry PF01145 Band_7, Band 7 family. Contains a probable N-terminal signal sequence; hypothetical protein complement(1285437..1286384) Neisseria meningitidis Z2491 907789 YP_002342737.1 CDS NMA1383 NC_003116.1 1286399 1286806 R NMA1383, membrane protein, len: 135 aa; unknown, contains hydrophobic, membrane-spanning regions; hypothetical protein complement(1286399..1286806) Neisseria meningitidis Z2491 907790 YP_002342738.1 CDS ung NC_003116.1 1286887 1287546 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1286887..1287546 Neisseria meningitidis Z2491 907791 YP_002342739.1 CDS NMA1386 NC_003116.1 1290250 1290651 R hypothetical protein complement(1290250..1290651) Neisseria meningitidis Z2491 7163868 YP_002342740.1 CDS NMA1391 NC_003116.1 1290696 1291211 R NMA1391, periplasmic protein, len: 171 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein complement(1290696..1291211) Neisseria meningitidis Z2491 907794 YP_002342741.1 CDS NMA1394 NC_003116.1 1293624 1294019 R NMA1394, len: 131 aa; unknown; hypothetical protein complement(1293624..1294019) Neisseria meningitidis Z2491 907796 YP_002342742.1 CDS hom NC_003116.1 1294192 1295499 D catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1294192..1295499 Neisseria meningitidis Z2491 907797 YP_002342743.1 CDS NMA1396 NC_003116.1 1295492 1295926 D NMA1396, membrane protein, len: 144 aa; unknown, contains a hydrophobic, membrane-spanning region; hypothetical protein 1295492..1295926 Neisseria meningitidis Z2491 907798 YP_002342744.1 CDS NMA1397 NC_003116.1 1295985 1296254 R NMA1397, hupB, probable DNA-binding protein, len: 89 aa; similar to many e.g. SW:DBHB_ECOLI (EMBL:X53241),hupB, Escherichia coli DNA-binding protein HU-beta (90 aa), fasta scores; E(): 1.4e-19, 68.5% identity in 89 aa overlap. Similar to NMA1868, fasta scores; E(): 3.6e-21,69.7% identity in 89 aa overlap. Contains Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein and PS00045 Bacterial histone-like DNA-binding proteins signature; DNA-binding protein complement(1295985..1296254) Neisseria meningitidis Z2491 907799 YP_002342745.1 CDS NMA1398 NC_003116.1 1296436 1298898 R NMA1398, lon, probable ATP-dependent protease, len: 820 aa; similar to many e.g. SW:LON_ECOLI (EMBL:L12349),lon, Escherichia coli ATP-dependent protease (EC 3.4.21.53) (784 aa), fasta scores; E(): 0, 65.5% identity in 796 aa overlap. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA), PS01046 ATP-dependent serine proteases, lon family,serine active site and PS00017 ATP/GTP-binding site motif A (P-loop); ATP-dependent protease complement(1296436..1298898) Neisseria meningitidis Z2491 907800 YP_002342746.1 CDS NMA1400 NC_003116.1 1299257 1300252 D NMA1400, len: 331 aa; unknown, shows weak similarity to parts bacterial hypothetical proteins e.g. TR:CAB49354 (EMBL:AJ248284) Pyrococcus abyssi hypothetical protein (197 aa), fasta scores; E(): 1.5e-06, 33.5% identity in 179 aa overlap. Contains PS00092 N-6 Adenine-specific DNA methylases signature; hypothetical protein 1299257..1300252 Neisseria meningitidis Z2491 907801 YP_002342747.1 CDS NMA1401 NC_003116.1 1300324 1302069 R NMA1401, recD, exodeoxyribonuclease V alpha subunit, len: 581 aa; highly similar to TR:O68924 (EMBL:AF058330), recD, Neisseria gonorrhoeae exodeoxyribonuclease V alpha subunit (581 aa), fasta scores; E(): 0, 95.2% identity in 580 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); exodeoxyribonuclease V subunit alpha complement(1300324..1302069) Neisseria meningitidis Z2491 907802 YP_002342748.1 CDS NMA1402 NC_003116.1 1302137 1302832 R NMA1402, probable ABC-transporter ATP-binding protein, len: 231 aa; similar to many e.g. SW:GLNQ_BACST (EMBL:M61017), glnQ, Bacillus stearothermophilus glutamine transport ATP-binding protein (242 aa), blastp scores; Expect 3.6e-29 and SW:YCFV_ECOLI (EMBL:AE000212), ycfV,Escherichia coli hypothetical ABC transporter ATP-binding protein (233 aa), fasta scores; E(): 0, 53.8% identity in 223 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop); ABC transporter ATP-binding protein complement(1302137..1302832) Neisseria meningitidis Z2491 907803 YP_002342749.1 CDS NMA1403 NC_003116.1 1302825 1304072 R NMA1403, integral membrane protein, len: 415 aa; unknown, similar to many bacterial hypothetical proteins e.g. SW:YCFW_ECOLI (EMBL:AE000212), yxfW,Escherichia coli hypothetical protein (414 aa), fasta scores; E(): 0, 35.3% identity in 405 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein complement(1302825..1304072) Neisseria meningitidis Z2491 907804 YP_002342750.1 CDS NMA1405 NC_003116.1 1304278 1304556 D NMA1405, periplasmic protein, len: 92 aa; unknown, contains a N-terminal signal sequence; hypothetical protein 1304278..1304556 Neisseria meningitidis Z2491 907806 YP_002342751.1 CDS recR NC_003116.1 1304612 1305229 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(1304612..1305229) Neisseria meningitidis Z2491 907807 YP_002342752.1 CDS NMA1407 NC_003116.1 1305296 1306834 R NMA1407, peptidyl-prolyl cis-trans isomerase, len: 512 aa; similar to e.g. SW:CYPD_ECOLI (EMBL:AE000150), ppiD, Escherichia coli peptidyl-prolyl cis-trans isomerase D (EC 5.2.1.8) (623 aa), fasta scores; E(): 8.4e-14, 21.7% identity in 608 aa overlap. Contains a probable N-terminal signal sequence; peptidyl-prolyl cis-trans isomerase complement(1305296..1306834) Neisseria meningitidis Z2491 907808 YP_002342753.1 CDS NMA1408 NC_003116.1 1306888 1307262 R NMA1408, len: 124 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:YFFB_ECOLI (EMBL:X57403),yffB, Escherichia coli hypothetical protein (118 aa),fasta scores; E(): 5.8e-15, 38.5% identity in 117 aa overlap; hypothetical protein complement(1306888..1307262) Neisseria meningitidis Z2491 907809 YP_002342754.1 CDS NMA1409 NC_003116.1 1307412 1309040 D NMA1409, probable ABC-transporter ATP-binding protein, len: 542 aa; similar to many e.g. SW:TLRC_STRFR (EMBL:M57437), tlrC, Streptomyces fradiae tylosin resistance ATP-binding protein (548 aa), blastp scores; Expect 1.4e-45 and SW:YBIT_ECOLI (EMBL:AE000184), ybiT,Escherichia coli hypothetical ABC-transporter ATP-binding protein (530 aa), fasta scores; E(): 0, 65.6% identity in 543 aa overlap. Contains two Pfam matches to entry PF00005 ABC_tran, ABC transporter and two PS00017 ATP/GTP-binding site motif A (P-loop); ABC transporter ATP-binding protein 1307412..1309040 Neisseria meningitidis Z2491 907810 YP_002342755.1 CDS cca NC_003116.1 1309112 1310365 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 1309112..1310365 Neisseria meningitidis Z2491 907811 YP_002342756.1 CDS NMA1411 NC_003116.1 1310588 1310896 D NMA1411, len: 102 aa; unknown; hypothetical protein 1310588..1310896 Neisseria meningitidis Z2491 907812 YP_002342757.1 CDS ruvB NC_003116.1 1310978 1312009 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1310978..1312009 Neisseria meningitidis Z2491 907813 YP_002342758.1 CDS NMA1413 NC_003116.1 1312032 1312760 R NMA1413, rpe, probable ribulose-phosphate 3-epimerase, len: 242 aa; similar to many e.g. SW:RPE_ECOLI (EMBL:Z19601), rpe, Escherichia coli ribulose-phosphate 3-epimerase (EC 5.1.3.1) (225 aa),fasta scores; E(): 0, 66.2% identity in 225 aa overlap. Contains Pfam match to entry PF00834 Ribul_P_3_epim,Ribulose-phosphate 3 epimerase family, PS01085 Ribulose-phosphate 3-epimerase family signature 1 and PS01086 Ribulose-phosphate 3-epimerase family signature 2; ribulose-phosphate 3-epimerase complement(1312032..1312760) Neisseria meningitidis Z2491 907814 YP_002342759.1 CDS NMA1414 NC_003116.1 1313071 1313505 D NMA1414, periplasmic protein, len: 144 aa; shows weak similarity to SW:SPY_ECOLI (EMBL:Y07714), spy,Escherichia coli spheroplast protein (161 aa), fasta scores; E(): 0.0013, 27.6% identity in 134 aa overlap. Contains a N-terminal signal sequence; hypothetical protein 1313071..1313505 Neisseria meningitidis Z2491 907815 YP_002342760.1 CDS NMA1415 NC_003116.1 1313518 1314381 R NMA1415, len: 287 aa; unknown, similar to the C-terminal half of TR:Q55502 (EMBL:D64006) Synechocystis sp. (strain PCC 6803) hypothetical protein (436 aa), fasta scores; E(): 0, 46.9% identity in 241 aa overlap and also to TR:O66668 (EMBL:AE000684), AQ_336, Aquifex aeolicus hypothetical protein (196 aa), fasta scores; E(): 3.4e-19,46.5% identity in 142 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein complement(1313518..1314381) Neisseria meningitidis Z2491 907816 YP_002342761.1 CDS ribC NC_003116.1 1314389 1315006 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(1314389..1315006) Neisseria meningitidis Z2491 907817 YP_002342762.1 CDS NMA1417 NC_003116.1 1315169 1315747 R NMA1417, molybdopterin-guanine dinucleotide biosynthesis protein A, len: 192 aa; similar to bacterial mobA genes e.g. SW:MOBA_ECOLI (EMBL:L19201),mobA, Escherichia coli molybdopterin-guanine dinucleotide biosynthesis protein A (194 aa), fasta scores; E(): 1.9e-14, 31.4% identity in 185 aa overlap; molybdopterin-guanine dinucleotide biosynthesis protein A complement(1315169..1315747) Neisseria meningitidis Z2491 907818 YP_002342763.1 CDS NMA1418 NC_003116.1 1315989 1317761 D NMA1418, probable two-component system sensor kinase, len: 590 aa; similar to many e.g. SW:NARX_ECOLI (EMBL:X13360), narX, Escherichia coli nitrate/nitrite sensor protein (EC 2.7.3.-) (598 aa), fasta scores; E(): 3.2e-17, 25.9% identity in 609 aa overlap. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains two hydrophobic, membrane-spanning regions; two-component system sensor kinase 1315989..1317761 Neisseria meningitidis Z2491 907819 YP_002342764.1 CDS NMA1419 NC_003116.1 1317758 1318414 D NMA1419, probable two-component system response regulator, len: 218 aa; similar to many e.g. TR:CAB44989 (EMBL:AJ131854), narL, Pseudomonas stutzeri nitrate and nitrite response regulator (218 aa), fasta scores; E(): 8.5e-31, 43.3% identity in 210 aa overlap. Contains probable helix-turn-helix motif at aa 169-190 (Score 1324,+3.70 SD). Contains Pfam matches to entry PF00072 response_reg, Response regulator receiver domain and to entry PF00196 GerE, Bacterial regulatory proteins, luxR family and PS00622 Bacterial regulatory proteins, luxR family signature; two-component system response regulator 1317758..1318414 Neisseria meningitidis Z2491 907820 YP_002342765.1 CDS purM NC_003116.1 1318885 1319919 R catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase complement(1318885..1319919) Neisseria meningitidis Z2491 907822 YP_002342766.1 CDS NMA1424 NC_003116.1 1320677 1321351 D NMA1424, len: 224 aa; unknown; hypothetical protein 1320677..1321351 Neisseria meningitidis Z2491 907824 YP_002342767.1 CDS ribA NC_003116.1 1321344 1321937 D catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1321344..1321937 Neisseria meningitidis Z2491 907825 YP_002342768.1 CDS ribB NC_003116.1 1323578 1324669 D bifunctional enzyme DHBP synthase/GTP cyclohydrolase II-like protein; functions in riboflavin synthesis; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein 1323578..1324669 Neisseria meningitidis Z2491 907828 YP_002342769.1 CDS NMA1433 NC_003116.1 1326807 1328117 R NMA1433, len: 436 aa; unknown, similar to many hypothetical proteins e.g. SW:YCAJ_HAEIN (EMBL:U32833),HI1590, Haemophilus influenzae hypothetical protein (446 aa), fasta scores; E(): 0, 54.0% identity in 437 aa overlap. may have some role in DNA replication or repair as the N-terminal half is similar to yeast replication factors e.g. SW:RFC3_YEAST (EMBL:L18755), rfc3,Saccharomyces cerevisiae replication factor C 40 kD subunit (340 aa), fasta scores; E(): 1.4e-10, 30.5% identity in 233 aa overlap and to bacterial helicase components SW:RUVB_THEMA (EMBL:U38840), ruvB, Thermotoga maritima (334 aa), fasta scores; E(): 1.1e-07, 28.3% identity in 244 aa overlap. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA) and PS00017 ATP/GTP-binding site motif A (P-loop); recombination factor protein RarA complement(1326807..1328117) Neisseria meningitidis Z2491 907831 YP_002342770.1 CDS NMA1435 NC_003116.1 1328366 1328851 D NMA1435, len: 161 aa; unknown, lies within a region of unusually low GC content; hypothetical protein 1328366..1328851 Neisseria meningitidis Z2491 907832 YP_002342771.1 CDS NMA1436 NC_003116.1 1328851 1329630 D NMA1436, len: 259 aa; unknown, rich in Ser, Thr and Asn, lies within a region of unusually low GC content; hypothetical protein 1328851..1329630 Neisseria meningitidis Z2491 907833 YP_002342772.1 CDS NMA1437 NC_003116.1 1329902 1330816 R NMA1437, probable lysR-family transcriptional regulator, len: 304 aa; shows weak similarity to many e.g. SW:XAPR_ECOLI (EMBL:X63976), xapR, Escherichia coli xanthosine operon regulatory protein (294 aa), fasta scores; E(): 1.6e-11, 23.7% identity in 295 aa overlap and TR:O30441 (EMBL:AF006000), brg1, Bordetella pertussis transcriptional regulator homologue regulated by the oxygen-responsive transcriptional regulator btr (291 aa),fasta scores; E(): 5.4e-13, 28.7% identity in 296 aa overlap. Contains probable helix-turn-helix motif at aa 17-38 (Score 1810, +5.35 SD). Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and PS00044 Bacterial regulatory proteins, lysR family signature; lysR-family transcriptional regulator complement(1329902..1330816) Neisseria meningitidis Z2491 907834 YP_002342773.1 CDS NMA1438 NC_003116.1 1331072 1332541 D NMA1438, integral membrane protein, len: 489 aa; unknown, contains hydrophobic, membrane-spanning regions; integral membrane protein 1331072..1332541 Neisseria meningitidis Z2491 907835 YP_002342774.1 CDS NMA1439 NC_003116.1 1332793 1333164 D NMA1439, lipoprotein, len: 123 aa; unknown, contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 1332793..1333164 Neisseria meningitidis Z2491 907836 YP_002342775.1 CDS thrC NC_003116.1 1333237 1334646 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1333237..1334646 Neisseria meningitidis Z2491 907837 YP_002342776.1 CDS NMA1441 NC_003116.1 1334693 1335487 D NMA1441, len: 264 aa; unknown; hypothetical protein 1334693..1335487 Neisseria meningitidis Z2491 907838 YP_002342777.1 CDS NMA1442 NC_003116.1 1335675 1336451 D NMA1442, fpr, probable ferredoxin--NADP reductase,len: 258 aa; similar to many e.g. SW:FENR_AZOVI (EMBL:L36319), fpr, Azotobacter vinelandii ferredoxin--NADP reductase (EC 1.18.1.2) (257 aa), fasta scores; E(): 0, 69.8% identity in 255 aa overlap. Similar to NMA1664, fasta scores; E(): 1.3e-30, 34.6% identity in 257 aa overlap. Contains Pfam match to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain; ferredoxin--NADP reductase 1335675..1336451 Neisseria meningitidis Z2491 907839 YP_002342778.1 CDS NMA1444 NC_003116.1 1337108 1339579 R NMA1444, probable P-type cation-transporting ATPase, len: 823 aa; similar to many e.g. SW:COPA_ENTHR (EMBL:L13292), copA, Enterococcus hirae copper/potassium-transporting ATPase A (EC 3.6.1.36) (727 aa), fasta scores; E(): 0, 34.0% identity in 744 aa overlap. Similar to NMA1539, fasta scores; E(): 0, 34.4% identity in 735 aa overlap. Contains hydrophobic, probable membrane-spanning regions. Contains two Pfam matches to entry PF00122 E1-E2_ATPase, E1-E2 ATPases and PS00154 E1-E2 ATPases phosphorylation site; P-type cation-transporting ATPase complement(1337108..1339579) Neisseria meningitidis Z2491 907841 YP_002342779.1 CDS NMA1445 NC_003116.1 1339576 1340685 R NMA1445, len: 369 aa; unknown, similar to many hypothetical proteins contains ATP/GTP-binding domains e.g. SW:HFLX_ECOLI (EMBL:U00005), hflX,Escherichia coli GTP-binding protein (426 aa), fasta scores; E(): 0, 48.5% identity in 375 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein complement(1339576..1340685) Neisseria meningitidis Z2491 907842 YP_002342780.1 CDS NMA1446 NC_003116.1 1340759 1342039 R NMA1446, periplasmic protein, len: 426 aa; contains N-terminal signal sequence; hypothetical protein complement(1340759..1342039) Neisseria meningitidis Z2491 907843 YP_002342781.1 CDS NMA1447 NC_003116.1 1342192 1342917 R NMA1447, len: 241 aa; unknown, similar to bacterial hypothetical proteins e.g. SW:Y882_HAEIN (EMBL:U32770),HI0882, Haemophilus influenzae hypothetical protein (245 aa), fasta scores; E(): 0, 76.9% identity in 212 aa overlap; hypothetical protein complement(1342192..1342917) Neisseria meningitidis Z2491 907844 YP_002342782.1 CDS radC NC_003116.1 1342990 1343667 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(1342990..1343667) Neisseria meningitidis Z2491 907845 YP_002342783.1 CDS NMA1449 NC_003116.1 1343790 1345139 R NMA1449, gshA, probable glutamate--cysteine ligase,len: 449 aa; similar to TR:Q56277 (EMBL:U81808), gshA,Thiobacillus ferrooxidans glutamate--cysteine ligase (EC 6.3.2.2) (436 aa), fasta scores; E(): 0, 45.7% identity in 446 aa overlap; glutamate--cysteine ligase complement(1343790..1345139) Neisseria meningitidis Z2491 907846 YP_002342784.1 CDS leuC NC_003116.1 1345395 1346804 D dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1345395..1346804 Neisseria meningitidis Z2491 907847 YP_002342785.1 CDS NMA1451 NC_003116.1 1346901 1347155 D NMA1451, lipoprotein, len: 84 aa; unknown,contains N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein 1346901..1347155 Neisseria meningitidis Z2491 907848 YP_002342786.1 CDS leuD NC_003116.1 1347217 1347858 D catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1347217..1347858 Neisseria meningitidis Z2491 907849 YP_002342787.1 CDS NMA1453 NC_003116.1 1348033 1349304 D NMA1453, DNA modification methylase, len: 423 aa; almost identical to SW:MTN4_NEILA (EMBL:U06074) Neisseria lactamica modification methylase NlaIV (EC ) (423 aa), fasta scores; E(): 0, 99.1% identity in 423 aa overlap and TR:Q59605 (EMBL:U43735), dcmE, Neisseria gonorrhoeae modification methylase (EC ) (423 aa),fasta scores; E(): 0, 97.9% identity in 423 aa overlap. Also similar to others from Neisseria meningitidis e.g. NMA1035, fasta scores; E(): 4.5e-21, 29.2% identity in 432 aa overlap. Contains Pfam match to entry PF00145 DNA_methylase, C-5 cytosine-specific DNA methylase and PS00094 C-5 cytosine-specific DNA methylases active site. Lies within a region of unusually low GC content; DNA modification methylase 1348033..1349304 Neisseria meningitidis Z2491 907850 YP_002342788.1 CDS leuB NC_003116.1 1350085 1351155 D catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1350085..1351155 Neisseria meningitidis Z2491 907852 YP_002342789.1 CDS NMA1457 NC_003116.1 1351318 1351881 D NMA1457, periplasmic protein, len: 187 aa; unknown, contains a N-terminal signal sequence; hypothetical protein 1351318..1351881 Neisseria meningitidis Z2491 907853 YP_002342790.1 CDS aspA NC_003116.1 1352342 1353739 D catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 1352342..1353739 Neisseria meningitidis Z2491 907854 YP_002342791.1 CDS NMA1460 NC_003116.1 1353811 1354686 R NMA1460, probable integral membrane protein, len: 291 aa; similar to SW:YD76_HAEIN (EMBL:U32818), HI1376,Haemophilus influenzae hypothetical protein (291 aa),fasta scores; E(): 0, 54.8% identity in 292 aa overlap. Contains hydrophobic, membrane-spanning regions; integral membrane protein complement(1353811..1354686) Neisseria meningitidis Z2491 907855 YP_002342792.1 CDS NMA1461 NC_003116.1 1354688 1355410 R NMA1461, probable dnaJ-family protein, len: 240 aa; unknown, N-terminal approx. 70 aa contains a J-domain,suggesting involvement with hsp70, while the remainder of the protein contains two hydrophobic, membrane-spanning regions. Only the N-terminus shows significant similarity to other proteins e.g. SW:DNAJ_LEGPN (EMBL:U15010), dnaJ, Legionella pneumophila DnaJ protein (379 aa), fasta scores; E(): 1.6e-09,65.6% identity in 64 aa overlap. Contains Pfam match to entry PF00226 DnaJ, DnaJ domain and PS00636 Nt-dnaJ domain signature; dnaJ-family protein complement(1354688..1355410) Neisseria meningitidis Z2491 907856 YP_002342793.1 CDS NMA1462 NC_003116.1 1355589 1356068 R NMA1462, len: 159 aa; unknown, shows weak similarity to SW:EBSC_ENTFA (EMBL:L23802) Enterococcus faecalis regulatory protein (164 aa), fasta scores; E(): 3.6e-08, 23.8% identity in 143 aa overlap and to other bacterial hypothetical proteins e.g. SW:YBAK_ECOLI (EMBL:AE000154), ybaK, Escherichia coli hypothetical protein (159 aa), fasta scores; E(): 1.2e-12,35.7% identity in 157 aa overlap; hypothetical protein complement(1355589..1356068) Neisseria meningitidis Z2491 907857 YP_002342794.1 CDS NMA1463 NC_003116.1 1356143 1356505 D NMA1463, len: 120 aa; unknown, similar to hypothetical proteins e.g. SW:Y117_HAEDU (EMBL:AF017750) Haemophilus ducreyi hypothetical protein (117 aa), fasta scores; E(): 1e-17, 46.8% identity in 111 aa overlap. Contains Pfam match to entry PF01042 DUF10, Domain of unknown function; hypothetical protein 1356143..1356505 Neisseria meningitidis Z2491 907858 YP_002342795.1 CDS NMA1464 NC_003116.1 1356537 1357403 D NMA1464, len: 288 aa; unknown, shows very weak similarity to some bacterial hypothetical proteins e.g. SW:UP14_ECOLI (EMBL:U28375), ygfZ, Escherichia coli hypothetical protein (325 aa), fasta scores; E(): 1.2e-07,25.0% identity in 284 aa overlap; hypothetical protein 1356537..1357403 Neisseria meningitidis Z2491 907859 YP_002342796.1 CDS NMA1465 NC_003116.1 1357496 1358455 D TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1357496..1358455 Neisseria meningitidis Z2491 907860 YP_002342797.1 CDS NMA1466 NC_003116.1 1358548 1361487 R NMA1466, probable type III restriction-modification system endonuclease, len: 979 aa; similar to many e.g. SW:T3RE_BPP1 (EMBL:X06287), res, bacteriophage P1 type III restriction-modification system EcoPI enzyme (EC 3.1.21.5) (970 aa), fasta scores; E(): 0, 55.8% identity in 980 aa overlap; type III restriction-modification system endonuclease complement(1358548..1361487) Neisseria meningitidis Z2491 907861 YP_002342798.1 CDS NMA1469 NC_003116.1 1363554 1364111 R NMA1469, ppiA, probable peptidyl-prolyl cis-trans isomerase A, len: 185 aa; similar to many e.g. SW:CYPH_ECOLI (EMBL:M55429), ppiB, Escherichia coli probable peptidyl-prolyl cis-trans isomerase A precursor (EC 5.2.1.8) (190 aa), fasta scores; E(): 9.4e-32, 54.9% identity in 182 aa overlap. Also similar to NMA1002, fasta scores; E(): 7.9e-21, 45.7% identity in 162 aa overlap. Contains Pfam match to entry PF00160 pro_isomerase,Peptidyl-prolyl cis-trans isomerase and PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature; peptidyl-prolyl cis-trans isomerase A complement(1363554..1364111) Neisseria meningitidis Z2491 907864 YP_002342799.1 CDS NMA1470 NC_003116.1 1364176 1365102 R NMA1470, len: 308 aa; unknown, similar to SW:YEIR_ECOLI (EMBL:AE000307), yeiR, Escherichia coli hypothetical protein (328 aa), fasta scores; E(): 1.1e-27,33.3% identity in 318 aa overlap. Also shows similarity at the N-terminus to SW:COBW_PSEDE (EMBL M62866), cobW,Pseudomonas denitrificans gene involved in cobalamin biosynthesis (353 aa), fasta scores; E(): 6.4e-11, 28.8% identity in 215 aa overlap; hypothetical protein complement(1364176..1365102) Neisseria meningitidis Z2491 907865 YP_002342800.1 CDS NMA1471 NC_003116.1 1365090 1365566 R NMA1471, cation uptake regulator, len: 158 aa; shows weak similarity to many cation uptake regulator proteins e.g. SW:ZUR_ECOLI (EMBL:U00006), zur, Escherichia coli zinc uptake regulation protein (171 aa), fasta scores; E(): 4.1e-07 30.6% identity in 160 aa overlap and SW:FUR_STAEP (EMBL:X97011), fur, Staphylococcus epidermidis ferric uptake regulation protein (138 aa),fasta scores; E(): 0.22, 22.8% identity in 158 aa overlap. Also similar to a protein identified as a virulence candidate in Pseudomonas aeruginosa TR:P72159 (EMBL:U58365), np20, fasta scores; E(): 1e-07, 37.3% identity in 75 aa overlap; cation uptake regulator complement(1365090..1365566) Neisseria meningitidis Z2491 907866 YP_002342801.1 CDS NMA1472 NC_003116.1 1365637 1366092 R NMA1472, probable low molecular weight protein-tyrosine-phosphatase, len: 151 aa; similar to many protein-tyrosine-phosphatases e.g. SW:PTPA_STRCO (EMBL:U37580), ptpA, Streptomyces coelicolor A3(2) low molecular weight protein-tyrosine-phosphatase (EC 3.1.3.48) (164 aa), fasta scores; E(): 3e-16, 39.2% identity in 153 aa overlap and SW:PPAL_SCHPO (EMBL:L33929), stp1, Schizosaccharomyces pombe low molecular weight phosphotyrosine protein phosphatase (EC 3.1.3.48) (156 aa), fasta scores; E(): 2.7e-13, 40.2% identity in 132 aa overlap. Contains Pfam match to entry PF01451 LMWPc, Low molecular weight phosphotyrosine protein phosphatase; protein-tyrosine-phosphatase complement(1365637..1366092) Neisseria meningitidis Z2491 907867 YP_002342802.1 CDS NMA1473 NC_003116.1 1366217 1367332 R NMA1473, len: 371 aa; unknown, similar to many bacterial hypothetical proteins e.g. SW:YXAA_BACSU (EMBL:AB005554), yxaA, Bacillus subtilis hypothetical protein (382 aa), fasta scores; E(): 0, 40.2% identity in 378 aa overlap. Lies within a region of unusually low GC content; hypothetical protein complement(1366217..1367332) Neisseria meningitidis Z2491 907868 YP_002342803.1 CDS NMA1474 NC_003116.1 1367446 1368543 R NMA1474, len: 365 aa; unknown; hypothetical protein complement(1367446..1368543) Neisseria meningitidis Z2491 907869 YP_002342804.1 CDS NMA1475 NC_003116.1 1368626 1370257 R NMA1475, len: 543 aa; unknown, shares N-terminal similarity with some bacterial hypothetical proteins e.g. TR:O05979 (EMBL:Y11779) Rickettsia prowazekii hypothetical protein (216 aa), fasta scores; E(): 3e-29, 43.8% identity in 185 aa overlap; hypothetical protein complement(1368626..1370257) Neisseria meningitidis Z2491 907870 YP_002342805.1 CDS NMA1476 NC_003116.1 1370357 1370641 R NMA1476, mercuric ion binding protein,len: 94 aa; similar to many small mercuric ion binding proteins e.g. SW:MERP_ACICA (EMBL:L04303), merP,Acinetobacter calcoaceticus plasmid pKLH2 mercuric transport protein periplasmic component precursor (91 aa),fasta scores; E(): 3e-06, 37.7% identity in 69 aa overlap and SW:MERP_PSEFL (EMBL:X73112), merP, Pseudomonas fluorescens plasmid pMER327 mercuric transport protein periplasmic component precursor (91 aa), fasta scores; E(): 4.9e-06, 36.2% identity in 69 aa overlap. Contains Pfam match to entry PF00403 HMA, Heavy-metal-associated domain; mercuric ion binding protein complement(1370357..1370641) Neisseria meningitidis Z2491 907871 YP_002342806.1 CDS NMA1478 NC_003116.1 1371201 1372637 D NMA1478, polysaccharide modification protein, len: 478 aa; similar to TR:Q51392 (EMBL:U50202),algI, Pseudomonas aeruginosa protein involved in alginate O-acetylation (520 aa), fasta scores; E(): 4.9e-33, 32.9% identity in 444 aa overlap and TR:O70067 (EMBL:AF049357),glg2, Streptococcus mutans CDS involved in intracellular polysaccharide accumulation (420 aa), fasta scores; E(): 1.5e-21, 28.7% identity in 407 aa overlap. Also shows weaker similarity to SW:DLTB_BACSU (EMBL:X73124), dltB,Bacillus subtilis protein involved in biosynthesis of D-alanyl-lipoteichoic acid (395 aa), fasta scores; E(): 3.1e-17, 25.3% identity in 395 aa overlap. Contains hydrophobic, membrane-spanning regions; polysaccharide modification protein 1371201..1372637 Neisseria meningitidis Z2491 907872 YP_002342807.1 CDS NMA1479 NC_003116.1 1372648 1373631 D NMA1479, periplasmic protein, len: 327 aa; unknown, contains a probable N-terminal signal sequence; hypothetical protein 1372648..1373631 Neisseria meningitidis Z2491 907873 YP_002342808.1 CDS NMA1480 NC_003116.1 1373628 1374821 D NMA1480, periplasmic protein, len: 397 aa; unknown, contains a N-terminal signal sequence; hypothetical protein 1373628..1374821 Neisseria meningitidis Z2491 907874 YP_002342809.1 CDS NMA1481 NC_003116.1 1375082 1376047 R NMA1481, probable transposase for IS1655, len: 321 aa; similar to many e.g. SW:TRA4_BACFR (EMBL:M17808) Bacteroides fragilis transposase for insertion sequence element (326 aa), fasta scores; E(): 0, 42.3% identity in 310 aa overlap. Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family. Contains probable helix-turn-helix motif at aa 22-43 (Score 1705, +4.99 SD); transposase for IS1655 complement(1375082..1376047) Neisseria meningitidis Z2491 907875 YP_002342810.1 CDS NMA1482 NC_003116.1 1376191 1377744 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1376191..1377744 Neisseria meningitidis Z2491 907876 YP_002342811.1 CDS NMA1483 NC_003116.1 1377835 1379817 R NMA1483, probable transmembrane transport protein,len: 660 aa; similar to many e.g. SW:OPUD_BACSU (EMBL:U50082), opuD, Bacillus subtilis glycine betaine transporter (512 aa), fasta scores; E(): 0, 42.8% identity in 493 aa overlap and SW:BETT_ECOLI (EMBL:X52905), betT,Escherichia coli high-affinity choline transport protein (677 aa), fasta scores; E(): 0, 34.2% identity in 663 aa overlap. Possibly involved in osmotic regulation. Highly similar to SW:YH06_HAEIN (EMBL:U32843), HI1706,Haemophilus influenzae probable transport protein (669 aa), fasta scores; E(): 0, 75.8% identity in 669 aa overlap. Contains hydrophobic, probable membrane-spanning regions. Contains PS01303 BCCT family of transporters signature; transmembrane transport protein complement(1377835..1379817) Neisseria meningitidis Z2491 907877 YP_002342812.1 CDS NMA1485 NC_003116.1 1380151 1382157 D NMA1485, gcr, site-specific recombinase, len: 668 aa; highly similar to TR:O05319 (EMBL:U82253) Neisseria gonorrhoeae site-specific recombinase (439 aa), fasta scores; E(): 0, 96.6% identity in 439 aa overlap. GC frameplot and codon usage plots predict a start codon 678 bp upstream of the functionally characterised start codon described in EMBL:U82253. The sequence described in EMBL:U82253 does not extend upstream of codon 188 in our predicted CDS; site-specific recombinase 1380151..1382157 Neisseria meningitidis Z2491 907879 YP_002342813.1 CDS NMA1486 NC_003116.1 1382368 1383333 D NMA1486, probable transposase for IS1655, len: 321 aa; similar to many e.g. SW:TRA4_BACFR (EMBL:M17808) Bacteroides fragilis transposase for insertion sequence element (326 aa), fasta scores; E(): 0, 42.3% identity in 310 aa overlap. Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family. Contains probable helix-turn-helix motif at aa 22-43 (Score 1705, +4.99 SD); transposase for IS1655 1382368..1383333 Neisseria meningitidis Z2491 907880 YP_002342814.1 CDS NMA1487 NC_003116.1 1383398 1383991 D NMA1487, transposase for IS1016, len: 197 aa; similar to many e.g. TR:Q48234 (EMBL:X59756) ORF from Haemophilus influenzae insertion sequence IS1016-V6 (191 aa), fasta scores; E(): 0, 70.3% identity in 175 aa overlap.; transposase for IS1016 1383398..1383991 Neisseria meningitidis Z2491 907881 YP_002342815.1 CDS NMA1488 NC_003116.1 1384238 1385230 R NMA1488, mltB, murein hydrolase, len: 321aa; similar to several eg. SW:P41052 (MLTB_ECOLI) membrane-bound lytic murein transglycosylase from Escherichia coli (361 aa) fasta scores; E(): 0, 38.4% identity in 310 aa overlap. Contains N-terminal signal sequence.; murein hydrolase complement(1384238..1385230) Neisseria meningitidis Z2491 907882 YP_002342816.1 CDS NMA1490 NC_003116.1 1385549 1387102 R NMA1490, oxidoreductase, len: 517aa; weakly similar to many acyl-dehydrogenases eg. SW:P52042 (ACDS_CLOAB) (379 aa) fasta scores; E(): 0.00073, 20.8% identity in 380 aa overlap.; oxidoreductase complement(1385549..1387102) Neisseria meningitidis Z2491 907884 YP_002342817.1 CDS NMA1491 NC_003116.1 1387161 1391051 D NMA1491, mfd, transcription-repair coupling factor,len: 1296aa; similar to many eg. SW:P30958 (MFD_ECOLI) (1148 aa) fasta scores; E(): 0, 44.2% identity in 1305 aa overlap. Contains Pfam match to entry PF00270 DEAD,DEAD/DEAH box helicase and to entry PF00271 helicase_C,Helicases conserved C-terminal domain; transcription-repair coupling factor 1387161..1391051 Neisseria meningitidis Z2491 907885 YP_002342818.1 CDS panD NC_003116.1 1391200 1391583 D Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 1391200..1391583 Neisseria meningitidis Z2491 907886 YP_002342819.1 CDS kdsA NC_003116.1 1391605 1392447 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1391605..1392447 Neisseria meningitidis Z2491 907887 YP_002342820.1 CDS NMA1494 NC_003116.1 1392462 1392902 D NMA1494, unknown, len: 146aa; N-terminal region similar to TR:O66525 (EMBL:AE000675) hypothetical protein (132 aa) fasta scores; E(): 0.005, 29.6% identity in 115 aa overlap.; hypothetical protein 1392462..1392902 Neisseria meningitidis Z2491 907888 YP_002342821.1 CDS eno NC_003116.1 1392950 1394236 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1392950..1394236 Neisseria meningitidis Z2491 907889 YP_002342822.1 CDS NMA1496 NC_003116.1 1394250 1394528 D NMA1496, unknown, len: 92aa; similar to SW:Q46894 (YGBQ_ECOLI) hypothetical protein from Escherichia coli (103 aa) fasta scores; E(): 1.1e-10, 46.6% identity in 88 aa overlap.; hypothetical protein 1394250..1394528 Neisseria meningitidis Z2491 907890 YP_002342823.1 CDS NMA1497 NC_003116.1 1394569 1394859 R NMA1497, iron-sulphur binding protein,len: 96aa; similar to SW:P37910 (YFAE_ECOLI) hypothetical protein from Escherichia coli (84 aa) fasta scores; E(): 4.2e-11, 45.8% identity in 83 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and Prosite match to PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.; iron-sulfur binding protein complement(1394569..1394859) Neisseria meningitidis Z2491 907891 YP_002342824.1 CDS nrdB NC_003116.1 1395057 1396190 R B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta complement(1395057..1396190) Neisseria meningitidis Z2491 907892 YP_002342825.1 CDS NMA1499 NC_003116.1 1396251 1397438 R NMA1499, type-II restriction endonuclease,len: 395aa; similar to SW:P14633 (T2E2_ECOLI) restriction endonuclease EcoRII from Escherichia coli (404 aa) fasta scores; E(): 2.9e-29, 34.4% identity in 392 aa overlap.; type-II restriction endonuclease complement(1396251..1397438) Neisseria meningitidis Z2491 907893 YP_002342826.1 CDS NMA1500 NC_003116.1 1397431 1398444 R NMA1500, probable modification methylase, len: 337aa; similar to many eg. SW:P05101 (MTS2_SHISO) modification methylase from Shigella sonnei (379 aa) fasta scores; E(): 0, 53.1% identity in 324 aa overlap. Contains Pfam match to entry PF00145 DNA_methylase, C-5 cytosine-specific DNA methylase and Prosite match to PS00095 C-5 cytosine-specific DNA methylases C-terminal signature and PS00094 C-5 cytosine-specific DNA methylases active site.; modification methylase complement(1397431..1398444) Neisseria meningitidis Z2491 907894 YP_002342827.1 CDS nrdA NC_003116.1 1398502 1400781 R Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha complement(1398502..1400781) Neisseria meningitidis Z2491 907895 YP_002342828.1 CDS NMA1503 NC_003116.1 1401310 1401621 D NMA1503, unknown, len: 103aa; hypothetical protein 1401310..1401621 Neisseria meningitidis Z2491 907896 YP_002342829.1 CDS NMA1504 NC_003116.1 1401933 1402700 R NMA1504, plsC, 1-acyl-SN-glycerol-3-phosphate acyltransferase, len: 255aa; similar to eg. TR:Q59618 (EMBL:U21807) plsC, 1-acyl-SN-glycerol-3-phosphate acyltransferase from Neisseria meningitidis serogroup B (257 aa) fasta scores; E(): 0, 97.3% identity in 257 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase. Contains membrane spanning hydrophobic regions.; 1-acyl-SN-glycerol-3-phosphate acyltransferase complement(1401933..1402700) Neisseria meningitidis Z2491 907897 YP_002342830.1 CDS NMA1505 NC_003116.1 1402788 1403615 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(1402788..1403615) Neisseria meningitidis Z2491 907898 YP_002342831.1 CDS NMA1506 NC_003116.1 1403667 1404332 R NMA1506, unknown, len: 221aa; hypothetical protein complement(1403667..1404332) Neisseria meningitidis Z2491 907899 YP_002342832.1 CDS NMA1507 NC_003116.1 1404510 1406486 D NMA1507, membrane-bound lytic murein transglycosylase, len: 658aa; similar to SW:P23931 (MLTD_ECOLI) membrane-bound lytic murein transglycosylase D precursor from Escherichia coli (452 aa) fasta scores; E(): 5.8e-31, 33.3% identity in 399 aa overlap. Contains three Pfam matches to entry PF01476 PG_binding_2, peptidoglycan binding domain and Pfam match to entry PF01464 SLT, Transglycosylase SLT domain.; membrane bound murein transglycosylase 1404510..1406486 Neisseria meningitidis Z2491 907900 YP_002342833.1 CDS NMA1508 NC_003116.1 1406554 1407246 D NMA1508, ribosomal small subunit pseudouridine synthase, len: 230aa; similar to many eg. SW:P33918 (RSUA_ECOLI) RsuA, ribosomal small subunit pseudouridine synthase A from Escherichia coli (231 aa) fasta scores; E(): 1.4e-21, 36.4% identity in 225 aa overlap. Contains Prosite match to PS01149 RsuA family of pseudouridine synthase signature.; ribosomal small subunit pseudouridine synthase 1406554..1407246 Neisseria meningitidis Z2491 907901 YP_002342834.1 CDS NMA1514 NC_003116.1 1409433 1410089 D NMA1514, cmk, cytidylate kinase, len: 218aa; similar to many eg. SW:P23863 (KCY_ECOLI) cmk, cytidylate kinase from Escherichia coli (227 aa) fasta scores; E(): 1.6e-30, 46.3% identity in 216 aa overlap; cytidylate kinase 1409433..1410089 Neisseria meningitidis Z2491 907903 YP_002342835.1 CDS rpsA NC_003116.1 1410244 1411929 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1410244..1411929 Neisseria meningitidis Z2491 907904 YP_002342836.1 CDS ihfB NC_003116.1 1411940 1412254 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1411940..1412254 Neisseria meningitidis Z2491 907905 YP_002342837.1 CDS NMA1517 NC_003116.1 1412605 1413012 R NMA1517, probable transcriptional regulator, len: 135aa; N-terminal region similar to many eg. SW:P22853 (MERR_BACSR) mercuric resistance operon regulator from Bacillus sp. (strain RC607) (132 aa) fasta scores; E(): 0.00031, 25.5% identity in 110 aa overlap. Also similar to SW:P44558 (Y186_HAEIN) hypothetical transcriptional regulator from Haemophilus influenzae (135 aa) fasta scores; E(): 0, 93.3% identity in 135 aa overlap. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and Prosite match to PS00552 Bacterial regulatory proteins, merR family signature. Also contains probable coiled-coil in the C-terminal region and helix-turn-helix 4-25aa (+3.80 SD).; transcriptional regulator complement(1412605..1413012) Neisseria meningitidis Z2491 907906 YP_002342838.1 CDS NMA1518 NC_003116.1 1413133 1414269 D NMA1518, adhC, alcohol dehydrogenase class-III,glutathione-dependent formaldehyde dehydrogenase, len: 378aa; similar to many eg. SW:P25437 (ADH3_ECOLI) adhC,alcohol dehydrogenase class-III from Escherichia coli (369 aa) fasta scores; E(): 0, 90.0% identity in 369 aa overlap. Contains Pfam match to entry PF00107 adh_zinc,Zinc-binding dehydrogenases and Prosite match to PS00059 Zinc-containing alcohol dehydrogenases signature.; alcohol dehydrogenase 1413133..1414269 Neisseria meningitidis Z2491 907907 YP_002342839.1 CDS NMA1519 NC_003116.1 1414278 1415105 D NMA1519, esd, esterase D, len: 275aa; similar to SW:P10768 (ESTD_HUMAN) esd, esterase D from Homo sapiens (Human) (282 aa) fasta scores; E(): 0, 52.9% identity in 278 aa overlap. Also similar to SW:P44556 (YAIM_HAEIN) hypothetical protein from Haemophilus influenzae (275 aa) fasta scores; E(): 0, 95.3% identity in 275 aa overlap. Contains Pfam match to entry PF00756 Esterase, esterase.; esterase D 1414278..1415105 Neisseria meningitidis Z2491 907908 YP_002342840.1 CDS NMA1520 NC_003116.1 1415498 1416649 D NMA1520, nucleotide-binding protein, len: 383aa; similar to many of undefined function eg. SW:P46442 (YHCM_ECOLI) hypothetical protein from Escherichia coli (375 aa) fasta scores; E(): 0, 38.1% identity in 370 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; nucleotide-binding protein 1415498..1416649 Neisseria meningitidis Z2491 907909 YP_002342841.1 CDS ndk NC_003116.1 1416708 1417133 D catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1416708..1417133 Neisseria meningitidis Z2491 907910 YP_002342842.1 CDS NMA1522 NC_003116.1 1417277 1418371 D NMA1522, conserved hypothetical protein, len: 364aa; similar to many eg. SW:Q51385 (YFGB_PSEAE) hypothetical protein from Pseudomonas aeruginosa (379 aa) fasta scores; E(): 0, 57.9% identity in 356 aa overlap.; hypothetical protein 1417277..1418371 Neisseria meningitidis Z2491 907911 YP_002342843.1 CDS NMA1523 NC_003116.1 1418374 1419135 D NMA1523, lipoprotein, len: 253aa; similar to TR:O67735 (EMBL:AE000762) hypothetical protein from Aquifex aeolicus (342 aa) fasta scores; E(): 3e-07, 29.7% identity in 195 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and uncleavable N-terminal signal sequence.; lipoprotein 1418374..1419135 Neisseria meningitidis Z2491 907912 YP_002342844.1 CDS ispG NC_003116.1 1419151 1420416 D catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1419151..1420416 Neisseria meningitidis Z2491 907913 YP_002342845.1 CDS clpP NC_003116.1 1420469 1421083 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(1420469..1421083) Neisseria meningitidis Z2491 907914 YP_002342846.1 CDS tig NC_003116.1 1421179 1422492 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(1421179..1422492) Neisseria meningitidis Z2491 907915 YP_002342847.1 CDS NMA1527 NC_003116.1 1422697 1425000 R NMA1527, ftsK-like cell division/stress response protein, len: 767aa; similar to many eg. TR:Q9Z3U1 (EMBL:AF095845) cell division/stress response protein from Pseudomonas syringae (801 aa) fasta scores; E(): 0, 44.7% identity in 774 aa overlap. Contains Pfam match to entry PF01580 FtsK_SpoIIIE and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; ftsK-like cell division/stress response protein complement(1422697..1425000) Neisseria meningitidis Z2491 907916 YP_002342848.1 CDS NMA1528 NC_003116.1 1425358 1426569 D NMA1528, uraA, uracil permease, len: 403aa; similar to many eg. SW:P41006 (PYRP_BACCL) uracil permease from Bacillus caldolyticus (432 aa) fasta scores; E(): 0, 45.3% identity in 395 aa overlap. Contains Pfam match to entry PF00860 xan_ur_permease, Xanthine/uracil permeases family and Prosite match to PS01116 Xanthine/uracil permeases family signature. Also contains membrane spanning hydrophobic regions.; uracil permease 1425358..1426569 Neisseria meningitidis Z2491 907917 YP_002342849.1 CDS NMA1529 NC_003116.1 1426621 1427103 R NMA1529, unknown, len: 160aa; hypothetical protein complement(1426621..1427103) Neisseria meningitidis Z2491 907918 YP_002342850.1 CDS NMA1532 NC_003116.1 1427686 1428432 D NMA1532, pss, phosphatidylserine synthase, len: 248aa; similar to many eg. SW:Q48269 (PSS_HELPY) pss,phosphatidylserine synthase from Helicobacter pylori (237 aa) fasta scores; E(): 5.9e-21, 35.7% identity in 221 aa overlap. Contains Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature. Also contains membrane spanning hydrophobic regions.; phosphatidylserine synthase 1427686..1428432 Neisseria meningitidis Z2491 907920 YP_002342851.1 CDS NMA1533 NC_003116.1 1428433 1429239 D NMA1533, conserved hypothetical integral membrane protein, len: 268aa; similar to many eg. SW:P44070 (Y902_HAEIN) hypothetical protein from Haemophilus influenzae (264 aa) fasta scores; E(): 5.1e-23, 33.7% identity in 261 aa overlap. Contains membrane spanning hydrophobic regions.; hypothetical protein 1428433..1429239 Neisseria meningitidis Z2491 907921 YP_002342852.1 CDS rplI NC_003116.1 1430027 1430479 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(1430027..1430479) Neisseria meningitidis Z2491 907922 YP_002342853.1 CDS rpsR NC_003116.1 1430496 1430726 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1430496..1430726) Neisseria meningitidis Z2491 907923 YP_002342854.1 CDS NMA1536 NC_003116.1 1430733 1431035 R NMA1536, priB, primosomal replication protein, len: 100aa; similar to many eg. SW:P07013 (PRIB_ECOLI) priB,primosomal replication protein N from Escherichia coli (103 aa) fasta scores; E(): 0.016, 31.2% identity in 77 aa overlap.; primosomal replication protein complement(1430733..1431035) Neisseria meningitidis Z2491 907924 YP_002342855.1 CDS rpsF NC_003116.1 1431036 1431404 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1431036..1431404) Neisseria meningitidis Z2491 907925 YP_002342856.1 CDS NMA1538 NC_003116.1 1431560 1432510 R NMA1538, trxB, thioredoxin reductase, len: 316aa; similar to many eg. SW:P09625 (TRXB_ECOLI) trxB,thioredoxin reductase from Escherichia coli (320 aa) fasta scores; E(): 0, 66.7% identity in 312 aa overlap. Contains Prosite match to PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site.; thioredoxin reductase complement(1431560..1432510) Neisseria meningitidis Z2491 907926 YP_002342857.1 CDS NMA1539 NC_003116.1 1432649 1434826 D NMA1539, probable cation-transporting ATPase, len: 725aa; similar to many eg. SW:P32113 (COPA_ENTHR) copper/potassium-transporting ATPase A from Enterococcus hirae (834 aa) fasta scores; E(): 0, 40.7% identity in 732 aa overlap. Contains Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPases, Pfam match to entry PF00403 HMA, Heavy-metal-associated domain, Prosite match to PS01047 Heavy-metal-associated domain and Prosite match to PS00154 E1-E2 ATPases phosphorylation site. Also contains membrane spanning hydrophobic regions.; cation-transporting ATPase 1432649..1434826 Neisseria meningitidis Z2491 907927 YP_002342858.1 CDS uvrC NC_003116.1 1434881 1436767 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1434881..1436767 Neisseria meningitidis Z2491 907928 YP_002342859.1 CDS NMA1541 NC_003116.1 1437010 1438443 D NMA1541, unknown, len: 477aa; hypothetical protein 1437010..1438443 Neisseria meningitidis Z2491 907929 YP_002342860.1 CDS trmB NC_003116.1 1438565 1439281 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 1438565..1439281 Neisseria meningitidis Z2491 907930 YP_002342861.1 CDS NMA1543 NC_003116.1 1439484 1440086 D NMA1543, Insertion element IS1016 transposase, len: 200aa; similar to many eg. TR:Q48208 (EMBL:X58176) from a compound transposon in Haemophilus influenzae (164 aa) fasta scores; E(): 0, 69.6% identity in 161 aa overlap. Similar to others from Neisseria meningitidis eg. NMA1956,fasta scores; E(): 0, 97.5% identity in 200 aa overlap.; Insertion element IS1016 transposase 1439484..1440086 Neisseria meningitidis Z2491 907931 YP_002342862.1 CDS NMA1544 NC_003116.1 1440251 1441015 R NMA1544, unknown, len: 254aa; lies in a region of unusually low GC content, some N-terminal similarity to TR:AAD38961 (EMBL:AF147978) hypothetical protein from Pseudomonas aeruginosa Bacteriophage D3 (170 aa) fasta scores; E(): 0.00049, 31.5% identity in 111 aa overlap.; hypothetical protein complement(1440251..1441015) Neisseria meningitidis Z2491 907932 YP_002342863.1 CDS uvrB NC_003116.1 1441083 1443110 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1441083..1443110) Neisseria meningitidis Z2491 907933 YP_002342864.1 CDS NMA1546 NC_003116.1 1443439 1444923 R NMA1546, carboxy-terminal processing protease, len: 494aa; similar to many eg. TR:Q44879 (EMBL:L37094) carboxy-terminal processing protease from Bartonella bacilliformis (434 aa) fasta scores; E(): 0,41.5% identity in 455 aa overlap. Contains Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF).; carboxy-terminal processing protease complement(1443439..1444923) Neisseria meningitidis Z2491 907934 YP_002342865.1 CDS NMA1547 NC_003116.1 1445043 1446848 R NMA1547, secreted lysine-rich protein, peptidase function, len: 601aa; contains probable N-terminal signal sequence and extensive coiled-coil regions and is largely hydrophilic. Also contains Pfam match to entry PF01551 Peptidase_M37.; hypothetical protein complement(1445043..1446848) Neisseria meningitidis Z2491 907935 YP_002342866.1 CDS NMA1549 NC_003116.1 1447176 1447736 D NMA1549, lipoprotein, function unknown,len: 186aa; similar to SW:P08367 (CREA_ECOLI) hypothetical protein from Escherichia coli fasta scores; E(): 1.5e-21,45.9% identity in 146 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; hypothetical protein 1447176..1447736 Neisseria meningitidis Z2491 907937 YP_002342867.1 CDS NMA1550 NC_003116.1 1447738 1448286 D NMA1550, conserved hypothetical protein, function unknown, len: 182aa; similar to several eg. SW:P52049 (YQGE_ECOLI) hypothetical protein from Escherichia coli (187 aa) fasta scores; E(): 3.2e-31, 44.1% identity in 188 aa overlap.; hypothetical protein 1447738..1448286 Neisseria meningitidis Z2491 907938 YP_002342868.1 CDS NMA1551 NC_003116.1 1448279 1448734 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 1448279..1448734 Neisseria meningitidis Z2491 907939 YP_002342869.1 CDS NMA1552 NC_003116.1 1448744 1449400 R NMA1552, hydrolase, len: 218aa; similar to the C-terminal region of TR:Q46978 (EMBL:Z37980) OPET decarboxylase from Escherichia coli (429 aa) fasta scores; E(): 1.4e-13, 30.7% identity in 199 aa overlap. Also similar to many of undefined function particularly TR:Q9ZHI3 (EMBL:AF061446) hypothetical protein from Chromobacterium violaceum (138 aa) fasta scores; E(): 3.5e-26, 56.2% identity in 137 aa overlap. Contains Pfam match to entry PF01557 FAA_hydrolase.; hydrolase complement(1448744..1449400) Neisseria meningitidis Z2491 907940 YP_002342870.1 CDS proS NC_003116.1 1449464 1451176 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(1449464..1451176) Neisseria meningitidis Z2491 907941 YP_002342871.1 CDS aceE NC_003116.1 1451870 1454533 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1451870..1454533 Neisseria meningitidis Z2491 907942 YP_002342872.1 CDS aceF NC_003116.1 1454683 1456290 D NMA1555, aceF, dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, len: 535aa; similar to many eg. SW:P06959 (ODP2_ECOLI) aceF,dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex from Escherichia coli (629 aa) fasta scores; E(): 0, 56.5% identity in 536 aa overlap. Contains two Pfam matches to entry PF00364 biotin_lipoyl,Biotin-requiring enzymes, Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and two Prosite matches to PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.; dihydrolipoamide acetyltransferase 1454683..1456290 Neisseria meningitidis Z2491 907943 YP_002342873.1 CDS NMA1556 NC_003116.1 1456368 1458152 D NMA1556, lpdA, dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes), len: 594aa; similar to many eg. SW:P00391 (DLDH_ECOLI) lpdA, dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes) from Escherichia coli (473 aa) fasta scores; E(): 0, 63.8% identity in 486 aa overlap. Also similar to TR:Q51188 (EMBL:X84696) from Neisseria meningitidis (594 aa) fasta scores; E(): 0, 97.0% identity in 594 aa overlap. Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes; Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase class-I; Prosite match to PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site and Prosite match to PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site.; dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes) 1456368..1458152 Neisseria meningitidis Z2491 907944 YP_002342874.1 CDS NMA1557 NC_003116.1 1458513 1460051 R NMA1557, unknown, len: 512aa; hypothetical protein complement(1458513..1460051) Neisseria meningitidis Z2491 907945 YP_002342875.1 CDS NMA1558 NC_003116.1 1460188 1462308 R NMA1558, TonB-dependent receptor protein,len: 706aa; weakly similar to many TonB-dependent receptor proteins eg. SW:P11461 (FATA_VIBAN) ferric anguibactin receptor precursor from Vibrio anguillarum (726 aa) fasta scores; E(): 8.2e-19, 25.5% identity in 722 aa overlap. Contains Pfam match to entry PF00593 TonB_boxC, TonB dependent receptor C-terminal region.; TonB-dependent receptor protein complement(1460188..1462308) Neisseria meningitidis Z2491 907946 YP_002342876.1 CDS NMA1559 NC_003116.1 1462567 1463352 R NMA1559, inositol monophosphate family protein,function unknown, len: 261aa; similar to many other inositol monophosphate family proteins eg. SW:P22783 (SUHB_ECOLI) extragenic suppressor protein from Escherichia coli (267 aa) fasta scores; E(): 0, 44.1% identity in 254 aa overlap. Contains Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family; Prosite match to PS00629 Inositol monophosphatase family signature 1 and Prosite match to PS00630 Inositol monophosphatase family signature 2.; inositol monophosphate family protein complement(1462567..1463352) Neisseria meningitidis Z2491 907947 YP_002342877.1 CDS NMA1560 NC_003116.1 1463533 1464411 D NMA1560, SpoU methylase family protein, len: 292aa; similar to many others of undefined function which carry a Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family eg. TR:P77438 (EMBL:AE000339) hypothetical protein from Escherichia coli (246 aa) fasta scores; E(): 2.7e-17, 36.2% identity in 260 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family.; SpoU methylase family protein 1463533..1464411 Neisseria meningitidis Z2491 907948 YP_002342878.1 CDS NMA1561 NC_003116.1 1464451 1465329 D NMA1561, unknown, len: 292aa; hypothetical protein 1464451..1465329 Neisseria meningitidis Z2491 907949 YP_002342879.1 CDS NMA1562 NC_003116.1 1465533 1465874 D NMA1562, unknown, len: 113aa; lies in a region of unusually low GC content.; hypothetical protein 1465533..1465874 Neisseria meningitidis Z2491 907950 YP_002342880.1 CDS NMA1563 NC_003116.1 1466222 1467478 D NMA1563, Sun-family protein, len: 418aa; C-terminal similar to many other SUN-family proteins eg. SW:P36929 (SUN_ECOLI) Sun protein from Escherichia coli (429 aa) fasta scores; E(): 1.3e-24, 32.6% identity in 356 aa overlap. Contains Pfam match to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family.; SUN-family protein 1466222..1467478 Neisseria meningitidis Z2491 907951 YP_002342881.1 CDS NMA1564 NC_003116.1 1468234 1468668 D NMA1564, unknown, len: 144aa; contains probable coiled-coil in the C-terminal region.; hypothetical protein 1468234..1468668 Neisseria meningitidis Z2491 907952 YP_002342882.1 CDS NMA1565 NC_003116.1 1468716 1470059 R NMA1565, probable aldehyde dehydrogenase, len: 447aa; similar to many eg. SW:P71016 (DHAB_BACSU) betaine aldehyde dehydrogenase from Bacillus subtilis (490 aa) fasta scores; E(): 0, 33.8% identity in 420 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase and Prosite match to PS00070 Aldehyde dehydrogenases cysteine active site.; aldehyde dehydrogenase complement(1468716..1470059) Neisseria meningitidis Z2491 907953 YP_002342883.1 CDS NMA1566 NC_003116.1 1470064 1470777 R NMA1566, conserved hypothetical protein, len: 237aa; similar to many eg. SW:P25743 (YCHE_ECOLI) hypothetical protein from Escherichia coli (215 aa) fasta scores; E(): 1.2e-20, 33.3% identity in 207 aa overlap.; hypothetical protein complement(1470064..1470777) Neisseria meningitidis Z2491 907954 YP_002342884.1 CDS gatC NC_003116.1 1470868 1471158 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 1470868..1471158 Neisseria meningitidis Z2491 907955 YP_002342885.1 CDS gatA NC_003116.1 1471221 1472666 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 1471221..1472666 Neisseria meningitidis Z2491 907956 YP_002342886.1 CDS NMA1569 NC_003116.1 1472663 1473595 D NMA1569, membrane protein, len: 310aa; similar to SW:Q57273 (YB19_HAEIN) hypothetical protein from Haemophilus influenzae (292 aa) fasta scores; E(): 1.9e-32, 37.6% identity in 295 aa overlap. Contains membrane spanning hydrophobic regions.; membrane protein 1472663..1473595 Neisseria meningitidis Z2491 907957 YP_002342887.1 CDS gatB NC_003116.1 1473638 1475068 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1473638..1475068 Neisseria meningitidis Z2491 907958 YP_002342888.1 CDS NMA1571 NC_003116.1 1475160 1476170 D NMA1571, iron/sulphur-binding oxidoreductase, len: 336aa; similar to many eg. SW:P37911 (ASCD_YERPS) CDP-6-deoxy-delta-3,4-glucoseen reductase from Yersinia pseudotuberculosis (328 aa) fasta scores; E(): 0, 40.4% identity in 329 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains; Pfam match to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain and Prosite match to PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.; iron/sulfur-binding oxidoreductase 1475160..1476170 Neisseria meningitidis Z2491 907959 YP_002342889.1 CDS pdxH NC_003116.1 1476300 1476932 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(1476300..1476932) Neisseria meningitidis Z2491 907960 YP_002342890.1 CDS NMA1573 NC_003116.1 1477432 1478202 D NMA1573, pseudouridine synthase, len: 256aa; similar to SW:P35159 (RLUB_BACSU) large subunit pseudouridine synthase B from Bacillus subtilis (229 aa) fasta scores; E(): 1e-21, 39.1% identity in 235 aa overlap. Also similar to many hypothetical proteins eg. SW:P37765 (YCIL_ECOLI) hypothetical protein from Escherichia coli (291 aa) fasta scores; E(): 0, 51.2% identity in 256 aa overlap. Contains Pfam match to entry PF01479 S4, S4 domain and Prosite match to PS01149 RsuA family of pseudouridine synthase signature.; pseudouridine synthase 1477432..1478202 Neisseria meningitidis Z2491 907961 YP_002342891.1 CDS NMA1574 NC_003116.1 1478271 1479812 R NMA1574, integral membrane transporter,len: 513aa; weakly similar to several monocarboxylate transporters (eukaryote) eg. SW:P53986 (MOT1_MOUSE) monocarboxylate transporter from Mus musculus (Mouse) (493 aa) fasta scores; E(): 5.7e-10, 23.8% identity in 479 aa overlap. Also similar to TR:Q9ZBV5 (EMBL:AL034443) integral membrane transporter from Streptomyces coelicolor (446 aa) fasta scores; E(): 0, 50.1% identity in 463 aa overlap.; integral membrane transporter complement(1478271..1479812) Neisseria meningitidis Z2491 907962 YP_002342892.1 CDS xseA NC_003116.1 1481025 1482380 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1481025..1482380) Neisseria meningitidis Z2491 907963 YP_002342893.1 CDS NMA1576 NC_003116.1 1482577 1483398 D NMA1576, nadE, NH(3)-dependent NAD synthetase, len: 273aa; similar to many egs. SW:Q58747 (NADE_METJA) probable NH(3)-dependent NAD synthetase from Methanococcus jannaschii (259 aa) fasta scores; E(): 3.9e-22, 35.1% identity in 259 aa overlap and SW:P08164 (NADE_BACSU) NH(3)-dependent NAD synthetase from Bacillus subtilis (272 aa) fasta scores; E(): 4.8e-15, 31.8% identity in 236 aa overlap.; NH(3)-dependent NAD synthetase 1482577..1483398 Neisseria meningitidis Z2491 907964 YP_002342894.1 CDS NMA1577 NC_003116.1 1483468 1483941 R NMA1577, unknown, len: 157aa; similar to SW:P39313 (YTFE_ECOLI) hypothetical protein from Escherichia coli (220 aa) fasta scores; E(): 3.7e-26, 45.7% identity in 151 aa overlap.; hypothetical protein complement(1483468..1483941) Neisseria meningitidis Z2491 907965 YP_002342895.1 CDS NMA1578 NC_003116.1 1484244 1484576 D NMA1578, trxA, thioredoxin I, len: 129aa; similar to many eg. SW:P00274 (THIO_ECOLI) trxA, thioredoxin I from Escherichia coli (108 aa) fasta scores; E(): 9.1e-27,61.1% identity in 108 aa overlap. Contains Pfam match to entry PF00085 thiored, Thioredoxin and Prosite match to PS00194 Thioredoxin family active site.; thioredoxin I 1484244..1484576 Neisseria meningitidis Z2491 907966 YP_002342896.1 CDS NMA1579 NC_003116.1 1484629 1485576 R NMA1579, unknown, len: 315aa; similar to the C-terminal region of many eg. SW:P44524 (YCBY_HAEIN) hypothetical protein from Haemophilus influenzae (711 aa) fasta scores; E(): 0, 48.4% identity in 316 aa overlap.; hypothetical protein complement(1484629..1485576) Neisseria meningitidis Z2491 907967 YP_002342897.1 CDS NMA1580 NC_003116.1 1485904 1487292 D NMA1580, probable ATP-dependent RNA helicase, len: 462aa; similar to many eg. SW:P25888 (RHLE_ECOLI) RhlE, ATP-dependent RNA helicase from Escherichia coli (454 aa) fasta scores; E(): 0, 44.0% identity in 466 aa overlap. Contains Pfam match to entry PF00270 DEAD,DEAD/DEAH box helicase; Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain; Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00039 DEAD-box subfamily ATP-dependent helicases signature.; ATP-dependent RNA helicase 1485904..1487292 Neisseria meningitidis Z2491 907968 YP_002342898.1 CDS NMA1581 NC_003116.1 1487937 1488491 R NMA1581, membrane lipoprotein, len: 184aa; contains N-terminal signal sequence, a membrane spanning hydrophobic region and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site; membrane lipoprotein complement(1487937..1488491) Neisseria meningitidis Z2491 907969 YP_002342899.1 CDS NMA1582 NC_003116.1 1488576 1489136 R NMA1582, unknown, len: 186aa; hypothetical protein complement(1488576..1489136) Neisseria meningitidis Z2491 907970 YP_002342900.1 CDS argD NC_003116.1 1489480 1490673 D DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase 1489480..1490673 Neisseria meningitidis Z2491 907972 YP_002342901.1 CDS clpX NC_003116.1 1490738 1491982 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1490738..1491982) Neisseria meningitidis Z2491 907973 YP_002342902.1 CDS rbfA NC_003116.1 1492173 1492544 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 1492173..1492544 Neisseria meningitidis Z2491 907974 YP_002342903.1 CDS NMA1587 NC_003116.1 1492534 1493079 D NMA1587, unknown, len: 543aa; hypothetical protein 1492534..1493079 Neisseria meningitidis Z2491 907975 YP_002342904.1 CDS truB NC_003116.1 1493137 1494057 D catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1493137..1494057 Neisseria meningitidis Z2491 907976 YP_002342905.1 CDS NMA1591 NC_003116.1 1496471 1499293 D NMA1591, type III restriction/modification system enzyme, len: 940aa; lies alongside a probable modification methylase. C-terminal similar to that from SW:P08764 (T3RE_BPP1) type III restriction/modification system EcoP1 restriction enzyme (970 aa) fasta scores; E(): 0.0039, 22.3% identity in 412 aa overlap. Also highly similar to TR:Q9ZHV5 (EMBL:AF048762) from Neisseria meningitidis (965 aa) fasta scores; E(): 0, 100.0% identity in 933 aa overlap. Lies in a DNA region of unusually low GC content.; type III restriction/modification system enzyme 1496471..1499293 Neisseria meningitidis Z2491 907979 YP_002342906.1 CDS NMA1592 NC_003116.1 1499437 1500609 R NMA1592, lldA, L-lactate dehydrogenase, len: 390aa; almost identical to TR:Q51135 (EMBL:U58911) lldA,L-lactate dehydrogenase from Neisseria meningitidis (390 aa) fasta scores; E(): 0, 99.7% identity in 390 aa overlap. Contains Pfam match to entry PF01070 FMN_dh,FMN-dependent dehydrogenase and Prosite match to PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site.; L-lactate dehydrogenase complement(1499437..1500609) Neisseria meningitidis Z2491 907980 YP_002342907.1 CDS NMA1593 NC_003116.1 1500899 1501345 D NMA1593, conserved hypothetical DNA-binding protein, len: 148aa; similar to many egs. SW:P77484 (YFHP_ECOLI) hypothetical protein from Escherichia coli (162 aa) fasta scores; E(): 1.8e-26,50.7% identity in 146 aa overlap and SW:Q51134 (YLDA_NEIME) hypothetical protein from Neisseria meningitidis (150 aa) fasta scores; E(): 0, 98.5% identity in 131 aa overlap. Contains helix-turn-helix 27-48aa (+2.63 SD).; DNA-binding protein 1500899..1501345 Neisseria meningitidis Z2491 907981 YP_002342908.1 CDS NMA1594 NC_003116.1 1501374 1502588 D catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 1501374..1502588 Neisseria meningitidis Z2491 907982 YP_002342909.1 CDS NMA1596 NC_003116.1 1502849 1503235 D NMA1596, NifU-like protein, len: 128aa; similar to many eg. TR:P77310 (EMBL:AE000339) NifU protein from Escherichia coli (128 aa) fasta scores; E(): 0, 84.4% identity in 128 aa overlap. Contains Pfam match to entry PF01592 NifU_N.; scaffold protein 1502849..1503235 Neisseria meningitidis Z2491 907984 YP_002342910.1 CDS NMA1597 NC_003116.1 1503322 1503642 D NMA1597, HesB-like protein, len: 106aa; similar to many HesB-like proteins eg. SW:P36539 (YFHF_ECOLI) hypothetical protein from Escherichia coli (107 aa) fasta scores; E(): 1.2e-27, 66.7% identity in 105 aa overlap. Contains Pfam match to entry PF01521 HesB-like and Prosite match to PS01152 Hypothetical hesB/yadR/yfhF family signature.; HesB-like protein 1503322..1503642 Neisseria meningitidis Z2491 907985 YP_002342911.1 CDS NMA1598 NC_003116.1 1503905 1504405 D NMA1598, hscB, chaperone protein, len: 166aa; similar to many eg. SW:P36540 (HSCB_ECOLI) hscB, chaperone protein from Escherichia coli (171 aa) fasta scores; E(): 3.2e-17, 41.3% identity in 160 aa overlap. Contains Pfam match to entry PF00226 DnaJ, DnaJ domain.; chaperone protein 1503905..1504405 Neisseria meningitidis Z2491 907986 YP_002342912.1 CDS NMA1599 NC_003116.1 1504503 1507253 D NMA1599, gyrA, DNA gyrase subunit A, len: 916aa; similar to many eg. SW:P48371 (GYRA_NEIGO) gyrA, DNA gyrase subunit A from Neisseria gonorrhoeae (916 aa) fasta scores; E(): 0, 97.3% identity in 916 aa overlap. Contains Pfam match to entry PF00521 DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A.; DNA gyrase subunit A 1504503..1507253 Neisseria meningitidis Z2491 907987 YP_002342913.1 CDS NMA1600 NC_003116.1 1507410 1507814 D NMA1600, transposase, len: 134aa; similar to (but missing a central 82aa portion) TR:Q9ZIX7 (EMBL:AF007429) transposase from Haemophilus gallinarum (216 aa) fasta scores; E(): 4.3e-22, 51.6% identity in 215 aa overlap. Contains helix-turn-helix 23-44aa (+3.20 SD).; transposase 1507410..1507814 Neisseria meningitidis Z2491 907988 YP_002342914.1 CDS NMA1603 NC_003116.1 1508859 1509410 R NMA1603, unknown, len: 183aa; contains probable coiled-coil regions.; hypothetical protein complement(1508859..1509410) Neisseria meningitidis Z2491 907993 YP_002342915.1 CDS pgi NC_003116.1 1509424 1511070 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1509424..1511070) Neisseria meningitidis Z2491 907994 YP_002342916.1 CDS NMA1605 NC_003116.1 1511191 1512039 R NMA1605, probable transcriptional regulator, len: 282aa; weakly similar to SW:P39266 (RPIR_ECOLI) Als operon repressor from Escherichia coli (296 aa) fasta scores; E(): 9.2e-21, 27.9% identity in 258 aa overlap. Also similar to many hypothetical proteins eg. SW:P46118 (YEBK_ECOLI) hypothetical protein from Escherichia coli (289 aa) fasta scores; E(): 0, 42.1% identity in 278 aa overlap. Contains Pfam match to entry PF01380 SIS, SIS domain; Pfam match to entry PF01418 HTH_6,Helix-turn-helix domain, rpiR family and Prosite match to PS00356 Bacterial regulatory proteins, lacI family signature.; transcriptional regulator complement(1511191..1512039) Neisseria meningitidis Z2491 907995 YP_002342917.1 CDS glk NC_003116.1 1512089 1513075 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(1512089..1513075) Neisseria meningitidis Z2491 907996 YP_002342918.1 CDS NMA1608 NC_003116.1 1513056 1513751 R NMA1608, pgl, 6-phosphogluconolactonase, len: 231aa; similar to TR:AAD22666 (EMBL:AF029673) pgl,6-phosphogluconolactonase from Pseudomonas aeruginosa (243 aa) fasta scores; E(): 2.9e-26, 41.7% identity in 218 aa overlap.; 6-phosphogluconolactonase complement(1513056..1513751) Neisseria meningitidis Z2491 907997 YP_002342919.1 CDS zwf NC_003116.1 1514031 1515476 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(1514031..1515476) Neisseria meningitidis Z2491 907998 YP_002342920.1 CDS edd NC_003116.1 1516094 1517929 D catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1516094..1517929 Neisseria meningitidis Z2491 907999 YP_002342921.1 CDS eda NC_003116.1 1518110 1518748 D catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1518110..1518748 Neisseria meningitidis Z2491 908000 YP_002342922.1 CDS NMA1614 NC_003116.1 1520242 1521291 D NMA1614, mutY, adenine glycosylase, len: 349aa; similar to many eg. SW:P17802 (MUTY_ECOLI) mutY, adenine glycosylase from Escherichia coli (350 aa) fasta scores; E(): 0, 44.6% identity in 343 aa overlap. Also almost identical to TR:Q9ZF41 (EMBL:AJ001313) mutY, adenine glycosylase from Neisseria meningitidis (346 aa) fasta scores; E(): 0, 99.7% identity in 346 aa overlap. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III and Prosite match to PS00764 Endonuclease III iron-sulfur binding region signature.; adenine glycosylase 1520242..1521291 Neisseria meningitidis Z2491 908003 YP_002342923.1 CDS NMA1616 NC_003116.1 1521454 1521636 D NMA1616, unknown, len: 60aa; hypothetical protein 1521454..1521636 Neisseria meningitidis Z2491 908005 YP_002342924.1 CDS NMA1617 NC_003116.1 1521708 1522268 D NMA1617, sodC, superoxide dismutase, len: 186aa; almost identical to SW:Q59623 (SODC_NEIME) sodC,superoxide dismutase from Neisseria meningitidis (186 aa) fasta scores; E(): 0, 99.5% identity in 186 aa overlap. Probably located in the periplasmic space. Contains Pfam match to entry PF00080 sodcu, Copper/zinc superoxide dismutase (SODC) and Prosite match to PS00332 Copper/Zinc superoxide dismutase signature 2.; superoxide dismutase 1521708..1522268 Neisseria meningitidis Z2491 908006 YP_002342925.1 CDS NMA1620 NC_003116.1 1523857 1526085 R NMA1620, probable cytolysin secretion ABC transporter, len: 742aa; similar to many involved in cytolysin secretion eg. SW:P26760 (RT1B_ACTPL) RTX-1 toxin secretion ATP-binding protein from Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae) (707 aa) fasta scores; E(): 0, 72.7% identity in 699 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter; Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region; Prosite match to PS00211 ABC transporters family signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; cytolysin secretion ABC transporter complement(1523857..1526085) Neisseria meningitidis Z2491 908009 YP_002342926.1 CDS NMA1621 NC_003116.1 1526885 1527424 R NMA1621, insertion element IS1016 transposase, len: 179aa; similar to many eg. TR:Q48234 (EMBL:X59756) IS1016 insertion sequence from Haemophilus influenzae (191 aa) fasta scores; E(): 0, 72.6% identity in 175 aa overlap. Similar to others from Neisseria meningitidis eg. NMA2185,fasta scores; E(): 0, 92.7% identity in 179 aa overlap.; insertion element IS1016 transposase complement(1526885..1527424) Neisseria meningitidis Z2491 908010 YP_002342927.1 CDS NMA1622 NC_003116.1 1527761 1528195 D NMA1622, unknown, len: 144aa; lies in a region of unusually low GC content.; hypothetical protein 1527761..1528195 Neisseria meningitidis Z2491 908011 YP_002342928.1 CDS NMA1623 NC_003116.1 1528206 1528427 D NMA1623, unknown, len: 73aa; lies in a region of unusually low GC content.; hypothetical protein 1528206..1528427 Neisseria meningitidis Z2491 908012 YP_002342929.1 CDS NMA1624 NC_003116.1 1528462 1529190 D NMA1624, integral membrane protein, len: 242aa; contains membrane spanning hydrophobic regions. Lies in a region of unusually low GC content.; integral membrane protein 1528462..1529190 Neisseria meningitidis Z2491 908013 YP_002342930.1 CDS NMA1625 NC_003116.1 1529177 1530229 D NMA1625, probable RTX-family exoprotein, len: 350aa; similar to regions of Neisseria meningitidis iron-regulated proteins egs. N-terminal region of SW:P55127 (FRPC_NEIME) FrpC (1829 aa) fasta scores; E(): 0, 78.8% identity in 146 aa overlap and N-terminal region of SW:P55126 (FRPA_NEIME) FrpA (1115 aa) fasta scores; E(): 0, 41.6% identity in 394 aa overlap. Contains a membrane spanning hydrophobic region.; RTX family exoprotein 1529177..1530229 Neisseria meningitidis Z2491 908014 YP_002342931.1 CDS NMA1626 NC_003116.1 1530284 1532377 D NMA1626, probable RTX-family exoprotein, len: 697aa; similar to regions of other RTX-family proteins particularly C-terminal region of SW:P55126 (FRPA_NEIME) iron-regulated protein from Neisseria meningitidis (1115 aa) fasta scores; E(): 0, 99.1% identity in 697 aa overlap and C-terminal region of SW:P55127 (FRPC_NEIME) iron-regulated protein from Neisseria meningitidis (1829 aa) fasta scores; E(): 0, 88.0% identity in 685 aa overlap. Contains three Pfam matches to entry PF00353 hemolysinCabind, Hemolysin-type calcium-binding proteins and three Prosite matches to PS00330 Hemolysin-type calcium-binding region signature.; RTX-family exoprotein 1530284..1532377 Neisseria meningitidis Z2491 908015 YP_002342932.1 CDS pepN NC_003116.1 1532719 1535322 R NMA1627, pepN, aminopeptidase N, len: 867aa; similar to many eg. SW:P04825 (AMPN_ECOLI) pepN,aminopeptidase N from Escherichia coli (869 aa) fasta scores; E(): 0, 48.4% identity in 868 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1, Peptidase family M1 and Prosite match to PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.; aminopeptidase complement(1532719..1535322) Neisseria meningitidis Z2491 908016 YP_002342933.1 CDS NMA1628 NC_003116.1 1535458 1536252 R NMA1628, unknown, len: 264aa; similar to TR:Q9ZLF2 (EMBL:AE001495) hypothetical protein from Helicobacter pylori J99 (276 aa) fasta scores; E(): 1.6e-15, 26.0% identity in 273 aa overlap.; hypothetical protein complement(1535458..1536252) Neisseria meningitidis Z2491 908017 YP_002342934.1 CDS NMA1630 NC_003116.1 1537001 1537870 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1537001..1537870) Neisseria meningitidis Z2491 908019 YP_002342935.1 CDS ruvC NC_003116.1 1537921 1538457 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(1537921..1538457) Neisseria meningitidis Z2491 908020 YP_002342936.1 CDS NMA1632 NC_003116.1 1538460 1538699 R NMA1632, fis, factor-for-inversion-stimulation protein, len: 79aa; similar to many eg. SW:P11028 (FIS_ECOLI) fis, factor-for-inversion-stimulation protein from Escherichia coli (98 aa) fasta scores; E(): 0, 44.0% identity in 75 aa overlap. Contains probable DNA-binding helix-turn-helix motif (+3.80 SD) 54-75aa. Also contains Pfam match to entry PF00158 sigma54, Sigma-54 transcription factors.; DNA-binding protein Fis complement(1538460..1538699) Neisseria meningitidis Z2491 908021 YP_002342937.1 CDS NMA1633 NC_003116.1 1538729 1539739 R NMA1633, conserved hypothetical protein, len: 336aa; similar to many eg. SW:P25717 (YHDG_ECOLI) hypothetical protein from Escherichia coli (321 aa) fasta scores; E(): 0, 53.3% identity in 321 aa overlap. Contains Pfam match to entry PF01207 UPF0034, Uncharacterized protein family UPF0034 and Prosite match to PS01136 Uncharacterized protein family UPF0034 signature.; hypothetical protein complement(1538729..1539739) Neisseria meningitidis Z2491 908022 YP_002342938.1 CDS NMA1634 NC_003116.1 1540105 1541478 D NMA1634, probable ATP-dependent RNA helicase, len: 457aa; similar to many eg. SW:P25888 (RHLE_ECOLI) ATP-dependent RNA helicase from Escherichia coli (454 aa) fasta scores; E(): 0, 46.2% identity in 457 aa overlap. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase; Pfam match to entry PF00271 helicase_C,Helicases conserved C-terminal domain; Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00039 DEAD-box subfamily ATP-dependent helicases signature.; ATP-dependent RNA helicase 1540105..1541478 Neisseria meningitidis Z2491 908023 YP_002342939.1 CDS NMA1635 NC_003116.1 1542053 1543180 D NMA1635, unknown, len: 375aa; hypothetical protein 1542053..1543180 Neisseria meningitidis Z2491 908024 YP_002342940.1 CDS NMA1636 NC_003116.1 1543210 1544088 D NMA1636, unknown, len: 292aa; hypothetical protein 1543210..1544088 Neisseria meningitidis Z2491 908025 YP_002342941.1 CDS lysS NC_003116.1 1544506 1546017 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(1544506..1546017) Neisseria meningitidis Z2491 908027 YP_002342942.1 CDS NMA1639 NC_003116.1 1546172 1547425 R NMA1639, probable integral membrane protein, len: 417aa; contains probable membrane spanning hydrophobic regions.; integral membrane protein complement(1546172..1547425) Neisseria meningitidis Z2491 908028 YP_002342943.1 CDS NMA1640 NC_003116.1 1547699 1549678 D NMA1640, aminopeptidase, len: 659aa; weakly similar to many both prokaryote and eukaryote eg. TR:Q95333 (EMBL:U55039) aminopeptidase P from Sus scrofa (Pig) (673 aa) fasta scores; E(): 0, 34.8% identity in 632 aa overlap. Contains Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24.; aminopeptidase 1547699..1549678 Neisseria meningitidis Z2491 908029 YP_002342944.1 CDS NMA1641 NC_003116.1 1550999 1551820 R NMA1641, probable insertion element IS1106 transposase, len: 273aa; similar to many transposases particularly SW:Q00840 (TRA6_NEIME) insertion element IS1106 transposase from Neisseria meningitidis (288 aa) fasta scores; E(): 0, 80.8% identity in 265 aa overlap.; insertion element IS1106 transposase complement(1550999..1551820) Neisseria meningitidis Z2491 908030 YP_002342945.1 CDS NMA1642 NC_003116.1 1552433 1553620 R NMA1642, porA, porin, class I outer membrane protein, len: 395aa; highly similar to many eg. TR:Q51240 (EMBL:X52995) porA, class I outer membrane protein from Neisseria meningitidis (392 aa) fasta scores; E(): 0,95.7% identity in 395 aa overlap. Contains Pfam match to entry PF00267 Gram-ve_porins, General diffusion Gram-negative porins and Prosite match to PS00576 General diffusion Gram-negative porins signature. Also similar to NM398, porB (43.7% identity in 398 aa overlap); porin complement(1552433..1553620) Neisseria meningitidis Z2491 908031 YP_002342946.1 CDS greA NC_003116.1 1556634 1557110 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1556634..1557110) Neisseria meningitidis Z2491 908032 YP_002342947.1 CDS aroA NC_003116.1 1557502 1558803 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1557502..1558803 Neisseria meningitidis Z2491 908033 YP_002342948.1 CDS NMA1645 NC_003116.1 1558846 1559379 R NMA1645, lipoprotein, len: 177aa; similar to many over a specific region which corresponds to a conserved domain of unknown function found in lipoproteins eg. SW:Q47151 (YAFL_ECOLI) hypothetical lipoprotein from Escherichia coli (249 aa) fasta scores; E(): 0, 37.2% identity in 156 aa overlap. Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein complement(1558846..1559379) Neisseria meningitidis Z2491 908034 YP_002342949.1 CDS NMA1646 NC_003116.1 1559588 1561165 R NMA1646, phopholipase D-family protein, len: 525aa; similar to many of undefined function eg. SW:P75919 (YMDC_ECOLI) hypothetical protein from Escherichia coli (493 aa) fasta scores; E(): 0, 48.7% identity in 460 aa overlap. Contains two Pfam matches to entry PF00614 PLDc,Phospholipase D. Active site motif. Also contains a membrane spanning hydrophobic region.; phopholipase D-family protein complement(1559588..1561165) Neisseria meningitidis Z2491 908035 YP_002342950.1 CDS NMA1647 NC_003116.1 1561226 1562767 R NMA1647, probable integral membrane protein, len: 513aa; similar to many with membrane spanning hydrophobic regions eg. SW:P31474 (YIEO_ECOLI) hypothetical protein from Escherichia coli (475 aa) fasta scores; E(): 0, 43.0% identity in 451 aa overlap. Contains membrane spanning hydrophobic regions.; integral membrane protein complement(1561226..1562767) Neisseria meningitidis Z2491 908036 YP_002342951.1 CDS NMA1648 NC_003116.1 1562916 1563695 D NMA1648, conserved hypothetical protein, len: 259aa; similar to others of undefined function eg. TR:O24951 (EMBL:AE000535) conserved hypothetical secreted protein from Helicobacter pylori (242 aa) fasta scores; E(): 0, 40.8% identity in 240 aa overlap.; hypothetical protein 1562916..1563695 Neisseria meningitidis Z2491 908037 YP_002342952.1 CDS NMA1649 NC_003116.1 1563692 1564393 D NMA1649, conserved hypothetical protein, len: 233aa; similar to TR:O24949 (EMBL:AE000535) hypothetical protein from Helicobacter pylori (211 aa) fasta scores; E(): 1.9e-11, 29.0% identity in 217 aa overlap.; hypothetical protein 1563692..1564393 Neisseria meningitidis Z2491 908038 YP_002342953.1 CDS NMA1650 NC_003116.1 1564390 1565844 D NMA1650, conserved hypothetical iron-sulphur protein, len: 484aa; similar to many eg. TR:O24950 (EMBL:AE000535) conserved hypothetical iron-sulphur protein from Helicobacter pylori (481 aa) fasta scores; E(): 0, 44.4% identity in 450 aa overlap. Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and two Prosite matches to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.; Fe-S protein 1564390..1565844 Neisseria meningitidis Z2491 908039 YP_002342954.1 CDS NMA1651 NC_003116.1 1566027 1566512 R NMA1651, purE, phosphoribosylaminoimidazole carboxylase catalytic subunit, len: 161aa; similar to many eg. SW:P12044 (PUR6_BACSU) purE,phosphoribosylaminoimidazole (162 aa) fasta scores; E(): 0, 66.2% identity in 151 aa overlap. Contains Pfam match to entry PF00731 AIRC, AIR carboxylase, score 300.10,E-value 2.8e-86.; phosphoribosylaminoimidazole carboxylase catalytic subunit complement(1566027..1566512) Neisseria meningitidis Z2491 908040 YP_002342955.1 CDS NMA1652 NC_003116.1 1566560 1567276 R NMA1652, periplasmic protein, len: 238aa; contains N-terminal signal sequence. Also contains probable coiled-coil region.; hypothetical protein complement(1566560..1567276) Neisseria meningitidis Z2491 908041 YP_002342956.1 CDS NMA1653 NC_003116.1 1567276 1567944 R NMA1653, methyltransferase, len: 222aa; similar to many methyltransferases egs. TR:Q50859 (EMBL:U24657) O-methyltransferase from DNA-binding antibiotic biosynthesis cluster of Myxococcus xanthus (220 aa) fasta scores; E(): 2.4e-26, 39.3% identity in 219 aa overlap. Contains Pfam match to entry PF01596 Methyltransf_3.; methyltransferase complement(1567276..1567944) Neisseria meningitidis Z2491 908042 YP_002342957.1 CDS mutL NC_003116.1 1568283 1570259 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 1568283..1570259 Neisseria meningitidis Z2491 908044 YP_002342958.1 CDS dnaZX NC_003116.1 1570354 1572483 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 1570354..1572483 Neisseria meningitidis Z2491 908045 YP_002342959.1 CDS NMA1657 NC_003116.1 1572563 1572898 D NMA1657, conserved hypothetical protein, len: 111aa; similar to many eg. SW:P44711 (YBAB_HAEIN) hypothetical protein from Haemophilus influenzae (109 aa) fasta scores; E(): 4.8e-19, 58.3% identity in 108 aa overlap. Contains probable coiled-coil region towards the N-terminus.; hypothetical protein 1572563..1572898 Neisseria meningitidis Z2491 908046 YP_002342960.1 CDS recA NC_003116.1 1574167 1575213 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1574167..1575213) Neisseria meningitidis Z2491 908047 YP_002342961.1 CDS aroD NC_003116.1 1575434 1576231 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1575434..1576231 Neisseria meningitidis Z2491 908048 YP_002342962.1 CDS NMA1660 NC_003116.1 1576251 1578266 D NMA1660, rep, ATP-dependent DNA helicase, len: 671aa; similar to many eg. SW:P09980 (REP_ECOLI) rep,ATP-deepndent DNA helicase from Escherichia coli (673 aa) fasta scores; E(): 0, 48.1% identity in 669 aa overlap. Contains Pfam match to entry PF00580 UvrD-helicase,UvrD/REP helicase and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; ATP-dependent DNA helicase 1576251..1578266 Neisseria meningitidis Z2491 908049 YP_002342963.1 CDS NMA1661 NC_003116.1 1578334 1579392 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(1578334..1579392) Neisseria meningitidis Z2491 908050 YP_002342964.1 CDS NMA1664 NC_003116.1 1583002 1583781 D NMA1664, probable ferredoxin NADP+ reductase, len: 259aa; similar to many ferredoxin NADP+ reductases eg. SW:P28861 (FENR_ECOLI) ferredoxin NADP+ reductase from Escherichia coli (247 aa) fasta scores; E(): 3.7e-22,32.3% identity in 254 aa overlap. Contains Pfam match to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain.; ferredoxin NADP+ reductase 1583002..1583781 Neisseria meningitidis Z2491 908053 YP_002342965.1 CDS NMA1665 NC_003116.1 1583992 1585404 R NMA1665, DNA polymerase III subunit, len: 470aa; similar to many eg. the central region of SW:P13267 (DPO3_BACSU) DNA polymerase III alpha chain from Bacillus subtilis (1437 aa) fasta scores; E(): 1.1e-11, 30.6% identity in 170 aa overlap. Contains Pfam match to entry PF00929 Exonuclease, Exonuclease.; DNA polymerase III subunit complement(1583992..1585404) Neisseria meningitidis Z2491 908054 YP_002342966.1 CDS NMA1666 NC_003116.1 1586222 1587397 D NMA1666, unknown, len: 391aa; similar to TR:O25465 (EMBL:AE000589) hypothetical protein from Helicobacter pylori (363 aa) fasta scores; E(): 1.2e-23, 30.7% identity in 387 aa overlap.; hypothetical protein 1586222..1587397 Neisseria meningitidis Z2491 908055 YP_002342967.1 CDS NMA1667 NC_003116.1 1587457 1588005 R NMA1667, inner membrane protein, len: 182aa; contains a membrane spanning hydrophobic region close to the N-terminus.; inner membrane protein complement(1587457..1588005) Neisseria meningitidis Z2491 908056 YP_002342968.1 CDS NMA1668 NC_003116.1 1588008 1589504 R NMA1668, ferredoxin, len: 498aa; similar to many ferredoxin-like proteins eg. SW:P18396 (FIXG_RHIME) FixG from Rhizobium meliloti (524 aa) fasta scores; E(): 0, 33.8% identity in 461 aa overlap. Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. Contains membrane spanning hydrophobic regions.; ferredoxin complement(1588008..1589504) Neisseria meningitidis Z2491 908057 YP_002342969.1 CDS tkt NC_003116.1 1590031 1592010 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1590031..1592010 Neisseria meningitidis Z2491 908058 YP_002342970.1 CDS fumC NC_003116.1 1592151 1593539 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1592151..1593539 Neisseria meningitidis Z2491 908059 YP_002342971.1 CDS NMA1671 NC_003116.1 1593604 1594527 R NMA1671, conserved hypothetical protein, len: 307aa; similar to many eg. SW:P71360 (YHBE_HAEIN) hypothetical protein from Haemophilus influenzae (306 aa) fasta scores; E(): 0, 48.2% identity in 307 aa overlap. Contains two Pfam matches to entry PF00892 DUF6, Integral membrane protein.; hypothetical protein complement(1593604..1594527) Neisseria meningitidis Z2491 908060 YP_002342972.1 CDS NMA1672 NC_003116.1 1594899 1595423 R NMA1672, ssb, single-stranded binding protein, len: 174aa; similar to many eg. SW:P02339 (SSB_ECOLI) ssb,single-stranded binding protein from Escherichia coli (177 aa) fasta scores; E(): 1.3e-22, 48.1% identity in 181 aa overlap. Contains Pfam match to entry PF00436 SSB,Single-strand binding protein family; Prosite match to PS00736 Single-strand binding protein family signature 2 and Prosite match to PS00735 Single-strand binding protein family signature 1.; ssDNA-binding protein complement(1594899..1595423) Neisseria meningitidis Z2491 908061 YP_002342973.1 CDS NMA1673 NC_003116.1 1595427 1596812 R NMA1673, probable integral membrane transporter,len: 461aa; similar to many proposed membrane transporters eg. TR:O67276 (EMBL:AE000729) transporter (major facilitator family) from Aquifex aeolicus (392 aa) fasta scores; E(): 0, 41.6% identity in 382 aa overlap. Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter and Prosite match to PS00216 Sugar transport proteins signature 1. Also contains probable membrane spanning hydrophobic regions.; integral membrane transporter complement(1595427..1596812) Neisseria meningitidis Z2491 908062 YP_002342974.1 CDS NMA1674 NC_003116.1 1596920 1597543 R NMA1674, transglycosylase, len: 207aa; regions of weak similarity to many eg. SW:P03810 (SLT_ECOLI) soluble lytic murein transglycosylase precursor from Escherichia coli (645 aa) fasta scores; E(): 0.1, 27.7% identity in 141 aa overlap. Contains Pfam match to entry PF01464 SLT, Transglycosylase SLT domain.; transglycosylase complement(1596920..1597543) Neisseria meningitidis Z2491 908063 YP_002342975.1 CDS NMA1675 NC_003116.1 1598453 1598869 R NMA1675, conserved hypothetical protein, len: 138aa; similar to others eg. SW:Q47152 (YAFM_ECOLI) hypothetical protein from Escherichia coli (165 aa) fasta scores; E(): 9.6e-30, 52.0% identity in 127 aa overlap. Also highly similar to NMA0532 form another region of the Neisseria meningitidis chromosome (138 aa) fasta scores; E(): 0, 99.3% identity in 138 aa overlap. Lies within a region of unusually low GC content.; hypothetical protein complement(1598453..1598869) Neisseria meningitidis Z2491 908064 YP_002342976.1 CDS NMA1679 NC_003116.1 1601826 1603334 D NMA1679, ppx/gppA, exopolyphosphatase, len: 502aa; similar to many exophosphatases including SW:P29014 (PPX_ECOLI) ppx, exopolyphosphatase from Escherichia coli (512 aa) fasta scores; E(): 0, 36.5% identity in 501 aa overlap and SW:P25552 (GPPA_ECOLI) guanosine pentaphosphate phosphohydrolase from Escherichia coli (494 aa) fasta scores; E(): 0, 34.3% identity in 499 aa overlap.; exopolyphosphatase 1601826..1603334 Neisseria meningitidis Z2491 908068 YP_002342977.1 CDS NMA1681 NC_003116.1 1604187 1604528 R NMA1681, unknown, len: 113aa; hypothetical protein complement(1604187..1604528) Neisseria meningitidis Z2491 908070 YP_002342978.1 CDS trpS NC_003116.1 1604534 1605544 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(1604534..1605544) Neisseria meningitidis Z2491 908071 YP_002342979.1 CDS NMA1683 NC_003116.1 1605805 1608384 D NMA1683, clpB, ClpB protein, len: 859aa; similar to many eg. SW:P03815 (CLPB_ECOLI) ClpB protein (ATPase subunit of clp protease) from Escherichia coli (857 aa) fasta scores; E(): 0, 66.4% identity in 857 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B; two Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop); Prosite match to PS00870 Chaperonins clpA/B signature 1 and Prosite match to PS00871 Chaperonins clpA/B signature 2. Also contains coiled-coil regions.; ClpB protein 1605805..1608384 Neisseria meningitidis Z2491 908072 YP_002342980.1 CDS NMA1684 NC_003116.1 1608471 1609685 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase complement(1608471..1609685) Neisseria meningitidis Z2491 908073 YP_002342981.1 CDS NMA1685 NC_003116.1 1609774 1609983 R NMA1685, tautomerase, len: 69aa; similar to many eg. SW:P49172 (DMPI_PSESP) 4-oxalocrotonate tautomerase from Pseudomonas sp. (strain CF600) (62 aa) fasta scores; E(): 0.32, 32.3% identity in 65 aa overlap. Also similar to SW:P45418 (YKDK_ERWCH) hypothetical protein from Erwinia chrysanthemi (73 aa) fasta scores; E(): 2.2e-15, 65.7% identity in 67 aa overlap. Contains Pfam match to entry PF01361 Tautomerase, Tautomerase enzyme.; tautomerase complement(1609774..1609983) Neisseria meningitidis Z2491 908074 YP_002342982.1 CDS NMA1686 NC_003116.1 1610328 1611134 D NMA1686, periplasmic protein, len: 268aa; similar to SW:P44196 (YE27_HAEIN) hypothetical protein from Haemophilus influenzae (278 aa) fasta scores; E(): 0,44.6% identity in 269 aa overlap. Seems to have a cleavable N-term signal seq.; hypothetical protein 1610328..1611134 Neisseria meningitidis Z2491 908075 YP_002342983.1 CDS NMA1687 NC_003116.1 1611192 1612457 R NMA1687, probable glutamate dehydrogenase, len: 421aa; similar to many eg. SW:P27346 (DHE2_CLODI) NAD-specific glutamate dehydrogenase (421 aa) fasta scores; E(): 0, 56.6% identity in 422 aa overlap. Contains Pfam match to entry PF00208 GLFV_dehydrog,Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; and Prosite match to PS00074 Glu / Leu / Phe / Val dehydrogenases active site.; glutamate dehydrogenase complement(1611192..1612457) Neisseria meningitidis Z2491 908076 YP_002342984.1 CDS NMA1688 NC_003116.1 1612864 1613571 D catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 1612864..1613571 Neisseria meningitidis Z2491 908077 YP_002342985.1 CDS recX NC_003116.1 1613639 1614100 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1613639..1614100 Neisseria meningitidis Z2491 908078 YP_002342986.1 CDS NMA1691 NC_003116.1 1614488 1614970 D NMA1691, acyl-CoA hydrolase, len: 160aa; weakly similar to the N-terminal region of TR:O08652 (EMBL:D88891) acyl-CoA hydrolase from Rattus norvegicus (Rat) (343 aa) fasta scores; E(): 1.7e-10, 32.2% identity in 152 aa overlap. Also similar to SW:O05729 (VDLD_HELPY) VdlD protein from Helicobacter pylori (174 aa) fasta scores; E(): 5.1e-30, 56.5% identity in 138 aa overlap. Contains Pfam match to entry PF01662 Acyl-CoA_hydro.; acyl-CoA hydrolase 1614488..1614970 Neisseria meningitidis Z2491 908080 YP_002342987.1 CDS NMA1692 NC_003116.1 1615331 1616578 R NMA1692, membrane peptidase, len: 415aa; similar to the C-terminal region of proposed lipoproteins eg. SW:P33648 (NLPD_ECOLI) lipoprotein from Escherichia coli (379 aa) fasta scores; E(): 3.3e-16, 36.4% identity in 321 aa overlap. Also similar to SW:P44833 (LPPB_HAEIN) outer membrane antigenic lipoprotein from Haemophilus influenzae (405 aa) fasta scores; E(): 1.4e-14, 30.5% identity in 446 aa overlap. Contains Pfam match to entry PF01551 Peptidase_M37, peptidoglycan binding domain; Pfam match to entry PF01476 PG_binding_2, peptidoglycan binding domain; Pfam match to entry PF01476 PG_binding_2, peptidoglycan binding domain and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; membrane peptidase complement(1615331..1616578) Neisseria meningitidis Z2491 908081 YP_002342988.1 CDS surE NC_003116.1 1616681 1617427 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(1616681..1617427) Neisseria meningitidis Z2491 908082 YP_002342989.1 CDS NMA1694 NC_003116.1 1617444 1619000 R NMA1694, conserved hypothetical integral membrane protein, len: 526aa; similar to many hypothetical proteins eg. SW:P76262 (YOAE_ECOLI) hypothetical protein from Escherichia coli (518 aa) fasta scores; E(): 0, 46.4% identity in 521 aa overlap. Contains two Pfam match to entry PF00571 CBS, CBS domain and probable membrane spanning hydrophobic regions.; hypothetical protein complement(1617444..1619000) Neisseria meningitidis Z2491 908083 YP_002342990.1 CDS NMA1695 NC_003116.1 1619368 1620156 R NMA1695, fimbrial assembly protein, len: 262aa; similar to several fimbrial assembly proteins SW:P17834 (FMBI_BACNO) fimbrial assembly protein from Bacteroides nodosus (257 aa) fasta scores; E(): 0, 39.0% identity in 254 aa overlap.; fimbrial assembly protein complement(1619368..1620156) Neisseria meningitidis Z2491 908084 YP_002342991.1 CDS NMA1696 NC_003116.1 1620265 1621698 R NMA1696, gabD, succinate semialdehyde dehydrogenase, len: 477aa; similar to many eg. SW:P25526 (GABD_ECOLI) gabD, succinate semialdehyde dehydrogenase from Escherichia coli (482 aa) fasta scores; E(): 0, 61.5% identity in 455 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase; Prosite match to PS00070 Aldehyde dehydrogenases cysteine active site and Prosite match to PS00687 Aldehyde dehydrogenases glutamic acid active site.; succinate semialdehyde dehydrogenase complement(1620265..1621698) Neisseria meningitidis Z2491 908085 YP_002342992.1 CDS NMA1697 NC_003116.1 1622362 1622742 R NMA1697, lipoprotein, len: 126aa; contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site; lipoprotein complement(1622362..1622742) Neisseria meningitidis Z2491 908086 YP_002342993.1 CDS NMA1698 NC_003116.1 1623218 1625299 D NMA1698, probable integral membrane protein (CstA-like), len: 693aa; strongly similar to SW:P15078 (CSTA_ECOLI) CstA, carbon starvation protein from Escherichia coli (701 aa) fasta scores; E(): 0, 62.1% identity in 683 aa overlap. Contains probable membrane-spanning hydrophobic regions.; integral membrane protein (CstA-like) 1623218..1625299 Neisseria meningitidis Z2491 908087 YP_002342994.1 CDS NMA1700 NC_003116.1 1627036 1629804 D NMA1700, outer membrane substrate binding protein, len: 922aa; weakly similar to several transferrin-binding proteins from Neisseria meningitidis eg. SW:Q06987 (TB12_NEIME) transferrin-binding protein (908 aa) fasta scores; E(): 1.9e-07, 23.5% identity in 833 aa overlap. Also similar to SW:P45114 (YC17_HAEIN) probable TonB receptor protein from Haemophilus influenzae (913 aa) fasta scores; E(): 0, 52.4% identity in 931 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS01156 TonB-dependent receptor proteins signature 2. Also contains a N-terminal signal sequence.; outer membrane substrate binding protein 1627036..1629804 Neisseria meningitidis Z2491 908089 YP_002342995.1 CDS lysC NC_003116.1 1630967 1632184 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase complement(1630967..1632184) Neisseria meningitidis Z2491 908090 YP_002342996.1 CDS rph NC_003116.1 1632386 1633114 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(1632386..1633114) Neisseria meningitidis Z2491 908091 YP_002342997.1 CDS NMA1703 NC_003116.1 1633196 1633660 R NMA1703, conserved hypothetical protein, len: 154aa; similar to many eg. TR:O06153 (EMBL:Z95554) hypothetical protein from Mycobacterium tuberculosis (146 aa) fasta scores; E(): 9.3e-10, 34.5% identity in 148 aa overlap. Contains Pfam match to entry PF00582 Usp,Universal stress protein family.; hypothetical protein complement(1633196..1633660) Neisseria meningitidis Z2491 908092 YP_002342998.1 CDS NMA1704 NC_003116.1 1633877 1634653 D NMA1704, conserved hypothetical protein, len: 258aa; similar to SW:Q46927 (YGDL_ECOLI) hypothetical protein from Escherichia coli (268 aa) fasta scores; E(): 0, 50.6% identity in 253 aa overlap. Contains Pfam match to entry PF00899 ThiF_family, ThiF family.; hypothetical protein 1633877..1634653 Neisseria meningitidis Z2491 908093 YP_002342999.1 CDS NMA1705 NC_003116.1 1634898 1635752 D NMA1705, unknown, len: 284aa; similar to many hypothetical proteins eg. SW:P35154 (YPUG_BACSU) hypothetical protein from Bacillus subtilis (251 aa) fasta scores; E(): 2.4e-16, 40.5% identity in 247 aa overlap.; hypothetical protein 1634898..1635752 Neisseria meningitidis Z2491 908094 YP_002343000.1 CDS pncB NC_003116.1 1635742 1637001 D catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1635742..1637001 Neisseria meningitidis Z2491 908095 YP_002343001.1 CDS argS NC_003116.1 1637093 1638811 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1637093..1638811 Neisseria meningitidis Z2491 908096 YP_002343002.1 CDS NMA1708 NC_003116.1 1639365 1640783 D NMA1708, unknown, len: 472aa; N-terminal region highly similar to one previously partially sequenced ie. TR:AAD24875 (EMBL:AF073777) hypothetical protein from Neisseria meningitidis (235 aa) fasta scores; E(): 0,90.8% identity in 196 aa overlap.; hypothetical protein 1639365..1640783 Neisseria meningitidis Z2491 908097 YP_002343003.1 CDS NMA1709 NC_003116.1 1641720 1642466 R NMA1709, binding-protein-dependent transport systems inner membrane protein, len: 248aa; similar to many eg. SW:P41074 (GLTJ_ECOLI) glutamate/aspartate transport system permease from Escherichia coli (246 aa) fasta scores; E(): 0, 31.2% identity in 231 aa overlap. Contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component and Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains membrane-spanning hydrophobic regions; binding-protein-dependent transport systems inner membrane protein complement(1641720..1642466) Neisseria meningitidis Z2491 908098 YP_002343004.1 CDS NMA1710 NC_003116.1 1642645 1643346 R NMA1710, nuclease, len: 233aa; similar to SW:P29769 (NUC_SHIFL) micrococcal nuclease from Shigella flexneri (174 aa) fasta scores; E(): 7e-08, 35.8% identity in 151 aa overlap. Contains Pfam match to entry PF00565 SNase, Staphylococcal nuclease homologues and Prosite match to PS01123 Thermonuclease family signature 1.; nuclease complement(1642645..1643346) Neisseria meningitidis Z2491 908099 YP_002343005.1 CDS rpiA NC_003116.1 1643385 1644056 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(1643385..1644056) Neisseria meningitidis Z2491 908100 YP_002343006.1 CDS ispF NC_003116.1 1644133 1644615 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(1644133..1644615) Neisseria meningitidis Z2491 908101 YP_002343007.1 CDS ispD NC_003116.1 1644647 1645336 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1644647..1645336) Neisseria meningitidis Z2491 908102 YP_002343008.1 CDS NMA1714 NC_003116.1 1645333 1646067 R NMA1714, dnaQ, DNA polymerase III, epsilon chain,len: 244aa; similar to many eg. SW:P03007 (DP3E_ECOLI) dnaQ, DNA polymerase III, epsilon chain from Escherichia coli (243 aa) fasta scores; E(): 0, 45.5% identity in 242 aa overlap. Contains Pfam match to entry PF00929 Exonuclease, Exonuclease.; DNA polymerase III subunit epsilon complement(1645333..1646067) Neisseria meningitidis Z2491 908103 YP_002343009.1 CDS NMA1715 NC_003116.1 1646223 1647533 R NMA1715, integral membrane protein, len: 436aa; weakly similar to many of undefined function eg. TR:O84647 (EMBL:AE001334) proposed efflux protein from Chlamydia trachomatis (559 aa) fasta scores; E(): 1.7e-16,25.1% identity in 442 aa overlap. Contains membrane-spanning hydrophobic regions.; integral membrane protein complement(1646223..1647533) Neisseria meningitidis Z2491 908104 YP_002343010.1 CDS NMA1716 NC_003116.1 1647523 1647711 R NMA1716, inner membrane protein, len: 62aa; contains a non-cleavable N-terminal signal sequence.; inner membrane protein complement(1647523..1647711) Neisseria meningitidis Z2491 908105 YP_002343011.1 CDS NMA1717 NC_003116.1 1647708 1648007 R NMA1717, unknown, len: 99aa; hypothetical protein complement(1647708..1648007) Neisseria meningitidis Z2491 908106 YP_002343012.1 CDS ackA1 NC_003116.1 1648328 1649554 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1648328..1649554 Neisseria meningitidis Z2491 908107 YP_002343013.1 CDS dipZ NC_003116.1 1650068 1651909 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein complement(1650068..1651909) Neisseria meningitidis Z2491 908108 YP_002343014.1 CDS NMA1720 NC_003116.1 1652000 1652470 D NMA1720, unknown, len: 156aa; hypothetical protein 1652000..1652470 Neisseria meningitidis Z2491 908109 YP_002343015.1 CDS NMA1721 NC_003116.1 1652541 1653371 R NMA1721, transferase, len: 276aa; similar to a region from many phytoene synthases eg. SW:P37272 (PSY_CAPAN) phytoene synthase from Capsicum annuum (Bell pepper) (419 aa) fasta scores; E(): 3e-17, 31.1% identity in 273 aa overlap. Also similar to hypothetical proteins eg. TR:O06001 (EMBL:X86552) hypothetical protein from Bradyrhizobium japonicum (294 aa) fasta scores; E(): 6.6e-23, 35.8% identity in 257 aa overlap. Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases.; transferase complement(1652541..1653371) Neisseria meningitidis Z2491 908110 YP_002343016.1 CDS NMA1722 NC_003116.1 1653440 1653922 R NMA1722, cis-trans isomerase, len: 160aa; similar to many eg. SW:P30856 (SLYD_ECOLI) SlyD,peptidyl-prolyl cis-trans isomerase from Escherichia coli (196 aa) fasta scores; E(): 8.8e-19, 42.3% identity in 163 aa overlap.; peptidyl-prolyl isomerase complement(1653440..1653922) Neisseria meningitidis Z2491 908111 YP_002343017.1 CDS NMA1723 NC_003116.1 1654411 1654743 D NMA1723, proline-rich repeat protein, len: 110aa; contains 7x K(LH)(PL)(LP)LK(HL)(LP)(PL)P repeat at 20-89aa.; hypothetical protein 1654411..1654743 Neisseria meningitidis Z2491 908112 YP_002343018.1 CDS NMA1724 NC_003116.1 1654801 1656168 D NMA1724, hypothetical protein, len: 455aa; C-terminal strongly similar to TR:Q51113 (EMBL:U23782) hypothetical protein (FRAGMENT) from Neisseria meningitidis (195 aa) fasta scores; E(): 0, 85.1% identity in 195 aa overlap. N-terminal region contains Pfam match to entry PF01565 FAD_binding_4.; hypothetical protein 1654801..1656168 Neisseria meningitidis Z2491 908113 YP_002343019.1 CDS NMA1725 NC_003116.1 1656349 1658277 R NMA1725, virulence associated protein,len: 642aa; strongly similar to TR:Q51112 (EMBL:U23782) from Neisseria meningitidis, designated as similar to Shigella flexneri VirG protein (682 aa) fasta scores; E(): 0, 81.7% identity in 650 aa overlap.; virulence associated protein complement(1656349..1658277) Neisseria meningitidis Z2491 908114 YP_002343020.1 CDS smpB NC_003116.1 1658738 1659190 R binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein complement(1658738..1659190) Neisseria meningitidis Z2491 908115 YP_002343021.1 CDS NMA1727 NC_003116.1 1659239 1660249 R NMA1727, rfaF, ADP-heptose:LPS heptosyltransferase II, len: 455aa; similar to many eg. TR:Q51063 (EMBL:Z37141) rfaF, ADP-heptose:LPS heptosyltransferase II from Neisseria gonorrhoeae (336 aa) fasta scores; E(): 0,96.4% identity in 336 aa overlap. Contains Pfam match to entry PF01075 Heptosyltranf, Heptosyltransferase.; ADP-heptose--LPS heptosyltransferase complement(1659239..1660249) Neisseria meningitidis Z2491 908116 YP_002343022.1 CDS NMA1728 NC_003116.1 1660646 1661515 R NMA1728, methylated-DNA-protein-cysteine methyltransferase, len: 289aa; C-terminal region similar to the methylated-DNA-protein-cysteine methyltransferase domain of many eg. SW:P19220 (ADAB_BACSU) methylated-DNA-protein-cysteine methyltransferase from Bacillus subtilis (179 aa) fasta scores; E(): 1.2e-20,44.0% identity in 141 aa overlap. C-terminal region contains Pfam match to entry PF01035 Methyltransf_1,6-O-methylguanine DNA methyltransferase and Prosite match to PS00374 Methylated-DNA--protein-cysteine methyltransferase active site.; methylated-DNA--protein-cysteine methyltransferase complement(1660646..1661515) Neisseria meningitidis Z2491 908117 YP_002343023.1 CDS NMA1729 NC_003116.1 1661673 1662233 D NMA1729, outer membrane protein, len: 186aa; similar to many hypothetical proteins especially in the N-terminal region eg. SW:P77368 (YBCL_ECOLI) hypothetical protein from Escherichia coli (183 aa) fasta scores; E(): 2.5e-13, 46.0% identity in 113 aa overlap.; hypothetical outer membrane protein 1661673..1662233 Neisseria meningitidis Z2491 908118 YP_002343024.1 CDS dapE NC_003116.1 1663067 1664212 R dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase complement(1663067..1664212) Neisseria meningitidis Z2491 908119 YP_002343025.1 CDS NMA1731 NC_003116.1 1664326 1664946 R NMA1731, conserved hypothetical protein, len: 206aa; similar to SW:P44013 (Y552_HAEIN) hypothetical protein from Haemophilus influenzae (207 aa) fasta scores; E(): 0, 59.6% identity in 203 aa overlap.; hypothetical protein complement(1664326..1664946) Neisseria meningitidis Z2491 908120 YP_002343026.1 CDS NMA1732 NC_003116.1 1664980 1665489 R NMA1732, conserved hypothetical protein, len: 169aa; similar to SW:P43971 (Y243_HAEIN) hypothetical protein from Haemophilus influenzae (172 aa) fasta scores; E(): 0, 49.7% identity in 169 aa overlap.; hypothetical protein complement(1664980..1665489) Neisseria meningitidis Z2491 908121 YP_002343027.1 CDS NMA1733 NC_003116.1 1665584 1666135 R NMA1733, H.8 outer membrane protein, len: 183aa; strongly similar to SW:P07212 (H8_NEIME) H.8 outer membrane protein from Neisseria meningitidis (183 aa) fasta scores; E(): 0, 96.7% identity in 183 aa overlap. Contains Pfam match to entry PF00127 copper-bind, Copper binding proteins, plastocyanin/azurin family and Prosite match to PS00196 Type-1 copper (blue) proteins signature.; outer membrane protein complement(1665584..1666135) Neisseria meningitidis Z2491 908122 YP_002343028.1 CDS secA NC_003116.1 1666969 1669719 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1666969..1669719 Neisseria meningitidis Z2491 908124 YP_002343029.1 CDS dnaG NC_003116.1 1669864 1671636 D synthesizes RNA primers at the replication forks; DNA primase 1669864..1671636 Neisseria meningitidis Z2491 908125 YP_002343030.1 CDS rpoD NC_003116.1 1671823 1673751 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 1671823..1673751 Neisseria meningitidis Z2491 908126 YP_002343031.1 CDS NMA1738 NC_003116.1 1673919 1674770 D NMA1738, insertion element IS1106 transposase, len: 283aa; similar to other copies eg. SW:Q00840 (TRA6_NEIME) transposase for insertion element IS1106 from Neisseria meningitidis (288 aa) fasta scores; E(): 0, 74.3% identity in 230 aa overlap.; insertion element IS1106 transposase 1673919..1674770 Neisseria meningitidis Z2491 908127 YP_002343032.1 CDS NMA1739 NC_003116.1 1676324 1679158 R NMA1739, lbpA, lactoferrin binding protein A, len: 944aa; similar to many eg. TR:Q51187 (EMBL:X79838) lbpA,lactoferrin binding protein A from Neisseria meningitidis (940 aa) fasta scores; E(): 0, 95.4% identity in 944 aa overlap. Contains Pfam match to entry PF00593 TonB_boxC,TonB dependent receptor C-terminal region and Prosite match to PS01156 TonB-dependent receptor proteins signature 2.; lactoferrin binding protein A complement(1676324..1679158) Neisseria meningitidis Z2491 908128 YP_002343033.1 CDS NMA1740 NC_003116.1 1679155 1681380 R NMA1740, lbpB, lactoferrin-binding protein, len: 741aa; similar to many eg. TR:AAD31768 (EMBL:AF123380) lbpB, lactoferrin-binding protein from Neisseria meningitidis (741 aa) fasta scores; E(): 0, 83.4% identity in 749 aa overlap. Contains Pfam match to entry PF01298 Lipoprotein_5, Transferrin binding protein and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains potential coiled-coil region around 460aa.; lactoferrin-binding protein complement(1679155..1681380) Neisseria meningitidis Z2491 908129 YP_002343034.1 CDS pyrG NC_003116.1 1684464 1686098 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(1684464..1686098) Neisseria meningitidis Z2491 908131 YP_002343035.1 CDS NMA1743 NC_003116.1 1686210 1687880 R NMA1743, fadD, long-chain-fatty-acid--CoA-ligase,len: 556aa; similar to many eg. SW:P29212 (LCFA_ECOLI) fadD, long-chain-fatty-acid--CoA-ligase from Escherichia coli (561 aa) fasta scores; E(): 0, 56.6% identity in 557 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Prosite match to PS00455 AMP-binding domain signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; long-chain-fatty-acid--CoA-ligase complement(1686210..1687880) Neisseria meningitidis Z2491 908132 YP_002343036.1 CDS mnmA NC_003116.1 1687951 1689102 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1687951..1689102) Neisseria meningitidis Z2491 908133 YP_002343037.1 CDS NMA1745 NC_003116.1 1689179 1689652 R NMA1745, unknown, len: 157 aa; similar to hypothetical proteins e.g. TR:O67294 (EMBL:AE000731) Aquifex aeolicus AQ_1253 (151 aa), fasta scores; E(): 1.1e-09, 33.1% identity in 151 aa overlap; hypothetical protein complement(1689179..1689652) Neisseria meningitidis Z2491 908138 YP_002343038.1 CDS NMA1746 NC_003116.1 1689789 1690172 R NMA1746, dgk, diacylglycerol kinase, len: 127aa; similar to many eg. SW:P00556 (KDGL_ECOLI) dgk,diacylglycerol kinase from Escherichia coli (121 aa) fasta scores; E(): 3.6e-12, 43.5% identity in 108 aa overlap. Contains Pfam match to entry PF01219 DAGK_prokar,Prokaryotic diacylglycerol kinase. Also contains membrane-spanning hydrophobic regions.; diacylglycerol kinase complement(1689789..1690172) Neisseria meningitidis Z2491 906026 YP_002343039.1 CDS gshB NC_003116.1 1690484 1691440 R catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase complement(1690484..1691440) Neisseria meningitidis Z2491 907674 YP_002343040.1 CDS glnS NC_003116.1 1691533 1693254 R catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase complement(1691533..1693254) Neisseria meningitidis Z2491 907673 YP_002343041.1 CDS NMA1749 NC_003116.1 1693333 1694106 R NMA1749, glpR, glycerol 3-phosphate regulon repressor, len: 257aa; similar to many eg. SW:P09392 (GLPR_ECOLI) glpR, glycerol 3-phosphate regulon repressor (252 aa) fasta scores; E(): 0, 43.9% identity in 253 aa overlap. Contains Pfam match to entry PF00455 deoR,Bacterial regulatory proteins, deoR family and Prosite match to PS00894 Bacterial regulatory proteins, deoR family signature. Also contains helix-turn-helix 22-43aa (+4.67 SD).; glycerol 3-phosphate regulon repressor complement(1693333..1694106) Neisseria meningitidis Z2491 907672 YP_002343042.1 CDS NMA1750 NC_003116.1 1694149 1695051 R NMA1750, hypothetical integral membrane protein,len: 300aa; similar to many hypothetical proteins eg. TR:BAA35588 (EMBL:D90724) hypothetical protein from Escherichia coli (299 aa) fasta scores; E(): 0, 39.0% identity in 300 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein complement(1694149..1695051) Neisseria meningitidis Z2491 907671 YP_002343043.1 CDS NMA1751 NC_003116.1 1695200 1695916 R NMA1751, gntR-family transcriptional regulator, len: 238aa; similar to many proposed transcriptional regulators eg. TR:CAB46933 (EMBL:AL096822) gntR-family transcriptional regulator from Streptomyces coelicolor (216 aa) fasta scores; E(): 5.8e-13, 32.7% identity in 199 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and helix-turn-helix 50-71aa (+3.34 SD).; gntR-family transcriptional regulator complement(1695200..1695916) Neisseria meningitidis Z2491 907670 YP_002343044.1 CDS NMA1753 NC_003116.1 1696485 1696835 R NMA1753, unknown, len: 116aa; similar to many of undefined function eg. SW:P24246 (YHFA_ECOLI) hypothetical protein from Escherichia coli (134 aa) fasta scores; E(): 1e-23, 51.8% identity in 114 aa overlap.; hypothetical protein complement(1696485..1696835) Neisseria meningitidis Z2491 908137 YP_002343045.1 CDS NMA1754 NC_003116.1 1697025 1697696 R NMA1754, unknown, len: 223aa; hypothetical protein complement(1697025..1697696) Neisseria meningitidis Z2491 907563 YP_002343046.1 CDS NMA1755 NC_003116.1 1697712 1698338 R NMA1755, purN, phosphoribosylglycinamide transformylase, len: 208aa; similar to many eg. SW:P08179 (PUR3_ECOLI) purN, phosphoribosylglycinamide transformylase from Escherichia coli (212 aa) fasta scores; E(): 0, 51.8% identity in 193 aa overlap. Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase.; phosphoribosylglycinamide transformylase complement(1697712..1698338) Neisseria meningitidis Z2491 907669 YP_002343047.1 CDS NMA1756 NC_003116.1 1698445 1699263 R NMA1756, peptidyl-prolyl isomerase, len: 272aa; similar to many eg. TR:O08437 (EMBL:U56832) peptidyl-prolyl isomerase from Aeromonas hydrophila (268 aa) fasta scores; E(): 5.4e-30, 44.5% identity in 265 aa overlap. Contains Pfam match to entry PF00254 FKBP,FKBP-type peptidyl-prolyl cis-trans isomerases; Pfam match to entry PF01346 FKBP_N, Domain amino terminal to FKBP-type peptidyl-prolyl isomerase and Prosite match to PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.; peptidyl-prolyl isomerase complement(1698445..1699263) Neisseria meningitidis Z2491 907668 YP_002343048.1 CDS NMA1757 NC_003116.1 1699522 1699962 R NMA1757, holC, DNA polymerase III chi subunit, len: 146aa; similar to SW:P28905 (HOLC_ECOLI) holC, DNA polymerase III chi subunit from Escherichia coli (147 aa) fasta scores; E(): 8.9e-05, 29.9% identity in 147 aa overlap.; DNA polymerase III subunit chi complement(1699522..1699962) Neisseria meningitidis Z2491 907667 YP_002343049.1 CDS NMA1758 NC_003116.1 1700025 1701431 R NMA1758, pepA, aminopeptidase A, len: 468aa; similar to many aminopeptidases eg. SW:P11648 (AMPA_ECOLI) pepA, aminopeptidase A from Escherichia coli (503 aa) fasta scores; E(): 0, 50.3% identity in 362 aa overlap. Contains Pfam match to entry PF00883 Peptidase_M17,Cytosol aminopeptidase family and Prosite match to PS00631 Cytosol aminopeptidase signature.; aminopeptidase complement(1700025..1701431) Neisseria meningitidis Z2491 907666 YP_002343050.1 CDS NMA1759 NC_003116.1 1701601 1702716 D NMA1759, conserved hypothetical integral membrane protein, len: 371aa; similar to SW:P39340 (YJGP_ECOLI) hypothetical protein from Escherichia coli (366 aa) fasta scores; E(): 2.1e-26, 29.2% identity in 360 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1701601..1702716 Neisseria meningitidis Z2491 907665 YP_002343051.1 CDS NMA1760 NC_003116.1 1702713 1703783 D NMA1760, conserved hypothetical integral membrane protein, len: 356aa; similar to many eg. SW:P39341 (YJGQ_ECOLI) hypothetical protein from Escherichia coli (361 aa) fasta scores; E(): 1.1e-32, 28.8% identity in 354 aa overlap. Contains membrane-spanning hydrophobic regions; hypothetical protein 1702713..1703783 Neisseria meningitidis Z2491 907664 YP_002343052.1 CDS acnB NC_003116.1 1704093 1706678 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 1704093..1706678 Neisseria meningitidis Z2491 907663 YP_002343053.1 CDS argF NC_003116.1 1706820 1707815 D catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 1706820..1707815 Neisseria meningitidis Z2491 907662 YP_002343054.1 CDS ilvC NC_003116.1 1708039 1709052 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(1708039..1709052) Neisseria meningitidis Z2491 907661 YP_002343055.1 CDS NMA1764 NC_003116.1 1709132 1709425 R NMA1764, conserved hypothetical protein, len: 97aa; similar to many eg. SW:P94425 (YCNE_BACSU) hypothetical protein from Bacillus subtilis (95 aa) fasta scores; E(): 4.5e-12, 48.6% identity in 74 aa overlap.; hypothetical protein complement(1709132..1709425) Neisseria meningitidis Z2491 907660 YP_002343056.1 CDS ilvH NC_003116.1 1709492 1709983 R with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit complement(1709492..1709983) Neisseria meningitidis Z2491 907659 YP_002343057.1 CDS NMA1766 NC_003116.1 1709994 1711721 R NMA1766, ilvI, acetolactate synthase isozyme III large subunit, len: 575aa; similar to many eg. SW:P00893 (ILVI_ECOLI) ilvI, acetolactate synthase isozyme III large subunit from Escherichia coli (574 aa) fasta scores; E(): 0, 57.5% identity in 572 aa overlap. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes and Prosite match to PS00187 Thiamine pyrophosphate enzymes signature.; acetolactate synthase isozyme III large subunit complement(1709994..1711721) Neisseria meningitidis Z2491 907658 YP_002343058.1 CDS NMA1767 NC_003116.1 1712842 1713495 D NMA1767, lipoprotein, len: 217aa; contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some similarity to several hypothetical proteins eg. TR:Q9ZCW7 (EMBL:AJ235272) hypothetical protein from Rickettsia prowazekii (205 aa) fasta scores; E(): 1.7e-19, 43.9% identity in 139 aa overlap.; lipoprotein 1712842..1713495 Neisseria meningitidis Z2491 907657 YP_002343059.1 CDS hisG NC_003116.1 1713574 1714227 D short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ; ATP phosphoribosyltransferase 1713574..1714227 Neisseria meningitidis Z2491 907656 YP_002343060.1 CDS NMA1769 NC_003116.1 1714331 1715230 D NMA1769, unknown, len: 229aa; hypothetical protein 1714331..1715230 Neisseria meningitidis Z2491 907655 YP_002343061.1 CDS hisD NC_003116.1 1715227 1716516 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1715227..1716516 Neisseria meningitidis Z2491 907654 YP_002343062.1 CDS hisC NC_003116.1 1716562 1717659 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1716562..1717659 Neisseria meningitidis Z2491 907653 YP_002343063.1 CDS hisB NC_003116.1 1717839 1718573 D catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1717839..1718573 Neisseria meningitidis Z2491 907652 YP_002343064.1 CDS NMA1773 NC_003116.1 1718668 1719537 D NMA1773, unknown, len: 289aa; similar to many of undefined function eg. TR:Q9ZLJ4 (EMBL:AE001491) dehydrogenase from Helicobacter pylori (285 aa) fasta scores; E(): 0, 44.2% identity in 285 aa overlap.; hypothetical protein 1718668..1719537 Neisseria meningitidis Z2491 907651 YP_002343065.1 CDS NMA1774 NC_003116.1 1719815 1720177 D NMA1774, transcriptional regulator, len: 120aa; similar to many of undefined function eg. SW:P42193 (PAPX_ECOLI) Papx protein from Escherichia coli (164 aa) fasta scores; E(): 0.024, 27.6% identity in 116 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family and helix-turn-helix motif 45-66aa (+3.67 SD).; transcriptional regulator 1719815..1720177 Neisseria meningitidis Z2491 907650 YP_002343066.1 CDS NMA1775 NC_003116.1 1720208 1721214 D insertion element IS1106A3 transposase join(1720208..1720540,1720540..1721214) Neisseria meningitidis Z2491 907649 YP_002343067.1 CDS NMA1777 NC_003116.1 1721483 1722346 D NMA1777, integral membrane protein, len: 287aa; contains membrane-spanning hydrophobic regions.; integral membrane protein 1721483..1722346 Neisseria meningitidis Z2491 907647 YP_002343068.1 CDS NMA1778 NC_003116.1 1722397 1723449 R SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease complement(1722397..1723449) Neisseria meningitidis Z2491 907646 YP_002343069.1 CDS NMA1779 NC_003116.1 1724296 1724859 R NMA1779, pgsA,CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, len: 187aa; similar to many eg. SW:P06978 (PGSA_ECOLI) pgsA,CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Escherichia coli (181 aa) fasta scores; E(): 2.3e-31, 51.1% identity in 182 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase and Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature.; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(1724296..1724859) Neisseria meningitidis Z2491 907645 YP_002343070.1 CDS NMA1781 NC_003116.1 1725086 1725388 R NMA1781, doubtful CDS, function unknown, len: 100aa; hypothetical protein complement(1725086..1725388) Neisseria meningitidis Z2491 907643 YP_002343071.1 CDS NMA1782 NC_003116.1 1725670 1726005 R NMA1782, conserved hypothetical protein, len: 111aa; similar to many eg. SW:Q57498 (YA53_HAEIN) hypothetical protein from Haemophilus influenzae (113 aa) fasta scores; E(): 6.3e-29, 75.9% identity in 112 aa overlap.; hypothetical protein complement(1725670..1726005) Neisseria meningitidis Z2491 907642 YP_002343072.1 CDS NMA1783 NC_003116.1 1726134 1727039 D NMA1783, AraC-family transcriptional regulator,len: 301aa; similar to many eg. TR:AAD44693 (EMBL:AF128627) MtrA AraC-like protein from Neisseria gonorrhoeae (301 aa) fasta scores; E(): 0, 94.0% identity in 301 aa overlap. Contains Pfam match to entry PF00165 HTH_2, Bacterial regulatory helix-turn-helix proteins,araC family.; AraC family transcriptional regulator 1726134..1727039 Neisseria meningitidis Z2491 907641 YP_002343073.1 CDS NMA1784 NC_003116.1 1727101 1727676 R NMA1784, unknown, len: 191aa; hypothetical protein complement(1727101..1727676) Neisseria meningitidis Z2491 907640 YP_002343074.1 CDS NMA1785 NC_003116.1 1727736 1728638 D NMA1785, conserved hypothetical integral membrane protein, transport function, len: 300aa; similar to many eg. TR:O83951 (EMBL:AE001266) conserved hypothetical integral membrane protein from Treponema pallidum (294 aa) fasta scores; E(): 2.4e-15, 31.4% identity in 271 aa overlap. Contains Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains membrane-spanning hydrophobic regions.; hypothetical protein 1727736..1728638 Neisseria meningitidis Z2491 907639 YP_002343075.1 CDS NMA1786 NC_003116.1 1728679 1729809 R NMA1786, polyamine permease substrate-binding protein, len: 376aa; similar to many eg. SW:P31133 (POTF_ECOLI) putrescine-binding periplasmic protein (370 aa) fasta scores; E(): 0, 43.2% identity in 347 aa overlap. Also similar to NMA0831 (fasta scores; E(): 0, 60.8% identity in 380 aa overlap) and NMA2023 fasta scores; (E(): 0, 55.2% identity in 377 aa overlap) from Neisseria meningitidis. Contains a cleavable N-terminal signal sequence.; polyamine permease substrate-binding protein complement(1728679..1729809) Neisseria meningitidis Z2491 907638 YP_002343076.1 CDS alaS NC_003116.1 1730014 1732638 D Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1730014..1732638 Neisseria meningitidis Z2491 907637 YP_002343077.1 CDS NMA1789 NC_003116.1 1732700 1733431 D NMA1789, unknown, len: 243aa; lies in a DNA region of unusually low GC content.; hypothetical protein 1732700..1733431 Neisseria meningitidis Z2491 907636 YP_002343078.1 CDS NMA1791 NC_003116.1 1734140 1736551 D NMA1791, unknown, len: 803aa; similar to but approx. 110aa shorter than TR:O30579 (EMBL:AF012532) hypothetical protein from Bacillus subtilis (879 aa) fasta scores; E(): 0, 38.5% identity in 816 aa overlap.; hypothetical protein 1734140..1736551 Neisseria meningitidis Z2491 907635 YP_002343079.1 CDS NMA1792 NC_003116.1 1737566 1738834 D NMA1792, unknown, len: 422aa; lies in a DNA region of unusually low GC content.; hypothetical protein 1737566..1738834 Neisseria meningitidis Z2491 907634 YP_002343080.1 CDS NMA1793 NC_003116.1 1738846 1739157 D NMA1793, unknown, len: 103aa; lies in a DNA region of unusually low GC content.; hypothetical protein 1738846..1739157 Neisseria meningitidis Z2491 907633 YP_002343081.1 CDS NMA1794 NC_003116.1 1739161 1739361 D NMA1794, unknown, len: 66aa; lies in a DNA region of unusually low GC content.; hypothetical protein 1739161..1739361 Neisseria meningitidis Z2491 907632 YP_002343082.1 CDS NMA1795 NC_003116.1 1739599 1739829 D NMA1795, unknown, len: 76aa; lies in a DNA region of unusually low GC content and contains membrane-spanning hydrophobic regions.; hypothetical protein 1739599..1739829 Neisseria meningitidis Z2491 907631 YP_002343083.1 CDS NMA1796 NC_003116.1 1739857 1740159 D NMA1796, unknown, len: 100aa; lies in a DNA region of unusually low GC content.; hypothetical protein 1739857..1740159 Neisseria meningitidis Z2491 907630 YP_002343084.1 CDS NMA1797 NC_003116.1 1740491 1742110 D NMA1797, tspB, TspB protein, len: 539aa; strongly similar to TR:O87783 (EMBL:AJ010115) a potent T-cell and B-cell stimulating Neisseria-specific antigen from Neisseria meningitidis (504 aa) fasta scores; E(): 0,85.6% identity in 465 aa overlap.; TspB protein 1740491..1742110 Neisseria meningitidis Z2491 907629 YP_002343085.1 CDS NMA1798 NC_003116.1 1742413 1742697 D NMA1798, integral membrane protein, len: 94aa; contains a non-cleavable N-terminal signal sequence and membrane-spanning hydrophobic region.; integral membrane protein 1742413..1742697 Neisseria meningitidis Z2491 907628 YP_002343086.1 CDS NMA1799 NC_003116.1 1742698 1743885 D NMA1799, unknown, len: 395aa; similar to TR:O82966 (EMBL:AB015669) hypothetical protein from Burkholderia solanacearum (364 aa) fasta scores; E(): 1.1e-20; 31.0% identity in 358 aa overlap.; hypothetical protein 1742698..1743885 Neisseria meningitidis Z2491 907627 YP_002343087.1 CDS NMA1800 NC_003116.1 1744100 1745056 D NMA1800, invertase/transposase, len: 318aa; similar to other proposed invertases eg. TR:P72078 (EMBL:U65994) pilin gene inverting protein homolog from Neisseria gonorrhoeae (320 aa) fasta scores; E(): 0, 42.6% identity in 317 aa overlap. Contains Pfam match to entry PF01548 Transposase_9.; invertase/transposase 1744100..1745056 Neisseria meningitidis Z2491 907626 YP_002343088.1 CDS gpmA NC_003116.1 1745395 1746078 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1745395..1746078) Neisseria meningitidis Z2491 907625 YP_002343089.1 CDS parC NC_003116.1 1746380 1748677 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 1746380..1748677 Neisseria meningitidis Z2491 907624 YP_002343090.1 CDS NMA1803 NC_003116.1 1748697 1750214 D NMA1803, two component sensor kinase, len: 505aa; similar to many eg. TR:Q51530 (EMBL:L22436) pilin transcripoitnal regulator (530 aa) fasta scores; E(): 4.3e-22; 25.8% identity in 496 aa overlap. Also strongly similar to TR:P72076 (EMBL:U65994) Rsp from Neisseria gonorrhoeae (572 aa) fasta scores; E(): 0, 75.5% identity in 335 aa overlap. Contains membrane-spanning hydrophobic regions in the N-terminal region and Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain in the C-terminal region.; two component sensor kinase 1748697..1750214 Neisseria meningitidis Z2491 907623 YP_002343091.1 CDS NMA1805 NC_003116.1 1750266 1750733 D NMA1805, two component response regulator,len: 155aa; similar to the N-terminus of many regulators eg. SW:Q00934 (PILR_PSEAE) PilR typeIV fimbriae expression regulator from Pseudomonas aeruginosa (446 aa) fasta scores; E(): 3.2e-14, 41.2% identity in 153 aa overlap. Contains Pfam match to entry PF00072 response_reg,Response regulator receiver domain and Pfam match to entry PF00158 sigma54, Sigma-54 transcription factors and helix-turn-helix motif 130-151 (+3.44 SD).; two component response regulator 1750266..1750733 Neisseria meningitidis Z2491 907622 YP_002343092.1 CDS NMA1806 NC_003116.1 1750837 1751589 D NMA1806, conserved hypothetical protein, len: 250aa; similar to many eg. SW:P72077 (YHIQ_NEIGO) hypothetical protein from Neisseria gonorrhoeae (250 aa) fasta scores; E(): 0, 95.6% identity in 250 aa overlap.; hypothetical protein 1750837..1751589 Neisseria meningitidis Z2491 907621 YP_002343093.1 CDS NMA1808 NC_003116.1 1752924 1754093 R NMA1808, metZ, O-succinylhomoserine sulfhydrolase,len: 389aa; similar to many eg. SW:P55218 (METZ_PSEAE) metZ, O-succinylhomoserine sulfhydrolase from Pseudomonas aeruginosa (403 aa) fasta scores; E(): 0, 49.9% identity in 381 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme.; O-succinylhomoserine sulfhydrolase complement(1752924..1754093) Neisseria meningitidis Z2491 907619 YP_002343094.1 CDS NMA1809 NC_003116.1 1754391 1755152 R NMA1809, unknown, len: 253aa; hypothetical protein complement(1754391..1755152) Neisseria meningitidis Z2491 907618 YP_002343095.1 CDS NMA1810 NC_003116.1 1755252 1755503 D NMA1810, unknown, len: 83aa; hypothetical protein 1755252..1755503 Neisseria meningitidis Z2491 907617 YP_002343096.1 CDS NMA1811 NC_003116.1 1755555 1756361 D NMA1811, hisJ, histidine-binding periplasmic protein, len: 268aa; similar to many eg. SW:Q06758 (HISJ_NEIGO) hisJ, histidine-binding periplasmic protein from Neisseria gonorrhoeae (268 aa) fasta scores; E(): 0,96.6% identity in 268 aa overlap. Contains Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.; histidine-binding periplasmic protein 1755555..1756361 Neisseria meningitidis Z2491 907616 YP_002343097.1 CDS NMA1812 NC_003116.1 1756551 1758191 D NMA1812, fumA, fumarate hydratase, len: 546aa; similar to many eg. SW:P00923 (FUMA_ECOLI) fumA, fumarate hydratase from Escherichia coli (547 aa) fasta scores; E(): 4.2e-33, 31.8% identity in 541 aa overlap.; fumarate hydratase 1756551..1758191 Neisseria meningitidis Z2491 907615 YP_002343098.1 CDS trkA NC_003116.1 1758289 1759701 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 1758289..1759701 Neisseria meningitidis Z2491 907614 YP_002343099.1 CDS NMA1814 NC_003116.1 1760005 1760970 D NMA1814, insertion element IS1655 transposase, len: 321aa; similar to many eg. SW:P37247 (TRA4_BACFR) transposase for insertion element IS4351 from Bacteroides fragilis (326 aa) fasta scores; E(): 0, 41.9% identity in 310 aa overlap. Also N-terminal region almost identical to TR:P72086 (EMBL:U56740) transposase homolog (fragment) from Neisseria meningitidis (104 aa) fasta scores; E(): 0,99.0% identity in 104 aa overlap. Contains Pfam match to entry PF01460 Transposase_4, Transposase IS30 family and helix-turn-helix motif 22-43aa (+4.99 SD).; insertion element IS1655 transposase 1760005..1760970 Neisseria meningitidis Z2491 907613 YP_002343100.1 CDS thiD NC_003116.1 1762484 1763290 D catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 1762484..1763290 Neisseria meningitidis Z2491 907612 YP_002343101.1 CDS NMA1816 NC_003116.1 1763340 1764194 R with TehA confers resistance to tellurite; tellurite resistance protein TehB complement(1763340..1764194) Neisseria meningitidis Z2491 907611 YP_002343102.1 CDS rnhA NC_003116.1 1764323 1764760 D An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 1764323..1764760 Neisseria meningitidis Z2491 907610 YP_002343103.1 CDS NMA1818 NC_003116.1 1766062 1766466 D NMA1818, unknown, len: 143aa; hypothetical protein 1766062..1766466 Neisseria meningitidis Z2491 907609 YP_002343104.1 CDS NMA1819 NC_003116.1 1766506 1767690 D NMA1819, conserved hypothetical protein, len: 394aa; regions similar to many eg. TR:O87499 (EMBL:AF081283) hypothetical protein from Escherichia coli (304 aa) fasta scores; E(): 0, 40.5% identity in 306 aa overlap.; hypothetical protein 1766506..1767690 Neisseria meningitidis Z2491 907608 YP_002343105.1 CDS NMA1820 NC_003116.1 1767753 1768286 R NMA1820, gpxA, glutathione peroxidase, len: 177aa; previously sequenced and characterised therefore identical to SW:P52036 (GPXA_NEIME) gpxA, glutathione peroxidase from Neisseria meningitidis (177 aa) fasta scores; E(): 0,100.0% identity in 177 aa overlap. Contains Pfam match to entry PF00255 GSHPx, Glutathione peroxidases; Prosite match to PS00763 Glutathione peroxidases signature 2 and Prosite match to PS00460 Glutathione peroxidases selenocysteine active site.; glutathione peroxidase complement(1767753..1768286) Neisseria meningitidis Z2491 907607 YP_002343106.1 CDS NMA1821 NC_003116.1 1768546 1769385 R NMA1821, conserved hypothetical protein, len: 279aa; similar to SW:P44243 (YF23_HAEIN) hypothetical protein from Haemophilus influenzae (296 aa) fasta scores; E(): 0, 47.3% identity in 277 aa overlap.; hypothetical protein complement(1768546..1769385) Neisseria meningitidis Z2491 907606 YP_002343107.1 CDS NMA1822 NC_003116.1 1769733 1770221 R NMA1822, unknown, len: 162aa; hypothetical protein complement(1769733..1770221) Neisseria meningitidis Z2491 907605 YP_002343108.1 CDS NMA1823 NC_003116.1 1770222 1770845 R NMA1823, unknown, len: 207aa; hypothetical protein complement(1770222..1770845) Neisseria meningitidis Z2491 907604 YP_002343109.1 CDS NMA1824 NC_003116.1 1770842 1773124 R NMA1824, unknown, len: 760aa; hypothetical protein complement(1770842..1773124) Neisseria meningitidis Z2491 907603 YP_002343110.1 CDS NMA1825 NC_003116.1 1773127 1773693 R NMA1825, unknown, len: 188aa; weakly similar to SW:P75982 (YMFQ_ECOLI) hypothetical protein from Escherichia coli (194 aa) fasta scores; E(): 1.1e-06,26.3% identity in 190 aa overlap.; hypothetical protein complement(1773127..1773693) Neisseria meningitidis Z2491 907602 YP_002343111.1 CDS NMA1826 NC_003116.1 1773690 1774265 R NMA1826, unknown, len: 191aa; hypothetical protein complement(1773690..1774265) Neisseria meningitidis Z2491 907601 YP_002343112.1 CDS NMA1827 NC_003116.1 1774268 1774753 R NMA1827, unknown, len: 161aa; hypothetical protein complement(1774268..1774753) Neisseria meningitidis Z2491 907600 YP_002343113.1 CDS NMA1828 NC_003116.1 1774750 1775103 R NMA1828, unknown, len: 117aa; hypothetical protein complement(1774750..1775103) Neisseria meningitidis Z2491 907599 YP_002343114.1 CDS NMA1829 NC_003116.1 1775164 1775793 R NMA1829, unknown, len: 209aa; note weak similarity to SW:P31340 (VPV_BPP2) baseplate assembly protein V from Bacteriophage P2 (211 aa) fasta scores; E(): 0.0055, 27.1% identity in 214 aa overlap.; hypothetical protein complement(1775164..1775793) Neisseria meningitidis Z2491 907598 YP_002343115.1 CDS NMA1830 NC_003116.1 1775794 1776933 R NMA1830, unknown, len: 379aa; note weak similarity to SW:P08558 (VPP_BPMU) 43kD tail protein from Bacteriophage Mu (379 aa) fasta scores; E(): 1.9e-11,26.2% identity in 362 aa overlap.; hypothetical protein complement(1775794..1776933) Neisseria meningitidis Z2491 907595 YP_002343116.1 CDS NMA1831 NC_003116.1 1776917 1778284 R NMA1831, unknown, len: 455aa; weak similarity to SW:P71389 (VPN_HAEIN) cryptic Mu-phage N protein from Haemophilus influenzae (455 aa) fasta scores; E(): 0,23.3% identity in 463 aa overlap.; hypothetical protein complement(1776917..1778284) Neisseria meningitidis Z2491 907594 YP_002343117.1 CDS NMA1832 NC_003116.1 1778284 1778526 R NMA1832, unknown, len: 80aa; hypothetical protein complement(1778284..1778526) Neisseria meningitidis Z2491 907593 YP_002343118.1 CDS NMA1833 NC_003116.1 1778654 1780333 R NMA1833, DNA-binding protein , len: 559aa; contains helix-turn-helix motif 84-105aa (+4.43 SD).; hypothetical protein complement(1778654..1780333) Neisseria meningitidis Z2491 907592 YP_002343119.1 CDS NMA1834 NC_003116.1 1780330 1780578 R NMA1834, unknown, len: 82aa; hypothetical protein complement(1780330..1780578) Neisseria meningitidis Z2491 907591 YP_002343120.1 CDS NMA1835 NC_003116.1 1780536 1780925 R NMA1835, unknown, len: 129aa; hypothetical protein complement(1780536..1780925) Neisseria meningitidis Z2491 907590 YP_002343121.1 CDS NMA1836 NC_003116.1 1781054 1781251 R NMA1836, unknown, len: 65aa; hypothetical protein complement(1781054..1781251) Neisseria meningitidis Z2491 907589 YP_002343122.1 CDS NMA1837 NC_003116.1 1781415 1781879 R NMA1837, unknown, len: 154aa; hypothetical protein complement(1781415..1781879) Neisseria meningitidis Z2491 907588 YP_002343123.1 CDS NMA1838 NC_003116.1 1781866 1782252 R NMA1838, DNA-binding protein, len: 128aa; contains helix-turn-helix motif 20-41aa (+2.60 SD).; hypothetical protein complement(1781866..1782252) Neisseria meningitidis Z2491 907587 YP_002343124.1 CDS NMA1840 NC_003116.1 1782428 1782802 R NMA1840, unknown, len: 124aa; hypothetical protein complement(1782428..1782802) Neisseria meningitidis Z2491 907586 YP_002343125.1 CDS NMA1841 NC_003116.1 1782816 1784243 R NMA1841, unknown, len: 475aa; similar to TR:P79678 (EMBL:AB000833) sheath protein from Bacteriophage Mu (495 aa) fasta scores; E(): 1.1e-10, 30.8% identity in 500 aa overlap.; hypothetical protein complement(1782816..1784243) Neisseria meningitidis Z2491 907585 YP_002343126.1 CDS NMA1842 NC_003116.1 1784243 1784431 R NMA1842, unknown, len: 62aa; hypothetical protein complement(1784243..1784431) Neisseria meningitidis Z2491 907583 YP_002343127.1 CDS NMA1843 NC_003116.1 1784428 1785096 R NMA1843, unknown, len: 222aa; hypothetical protein complement(1784428..1785096) Neisseria meningitidis Z2491 907582 YP_002343128.1 CDS NMA1844 NC_003116.1 1785080 1785505 R NMA1844, unknown, len: 141aa; similar to SW:P44230 (YF08_HAEIN) hypothetical protein from Haemophilus influenzae (141 aa) fasta scores; E(): 7.3e-10, 32.8% identity in 137 aa overlap.; hypothetical protein complement(1785080..1785505) Neisseria meningitidis Z2491 907581 YP_002343129.1 CDS NMA1845 NC_003116.1 1785502 1785975 R NMA1845, unknown, len: 157aa; contains coiled-coil region in the N-terminal half.; hypothetical protein complement(1785502..1785975) Neisseria meningitidis Z2491 907580 YP_002343130.1 CDS NMA1847 NC_003116.1 1786013 1786915 R NMA1847, conserved hypothetical protein, len: 300aa; similar to SW:P44230 (YF05_HAEIN) hypothetical protein from Haemophilus influenzae (308 aa) fasta scores; E(): 0, 53.6% identity in 306 aa overlap.; hypothetical protein complement(1786013..1786915) Neisseria meningitidis Z2491 907577 YP_002343131.1 CDS NMA1848 NC_003116.1 1786937 1788001 R NMA1848, hypothetical protein, len: 354aa; similar to SW:O05073 (VPI_HAEIN) cryptic Mu phage I protein from Haemophilus influenzae (355 aa) fasta scores; E(): 2.2e-15, 32.2% identity in 360 aa overlap.; hypothetical protein complement(1786937..1788001) Neisseria meningitidis Z2491 907576 YP_002343132.1 CDS NMA1849 NC_003116.1 1788210 1788707 R NMA1849, unknown, len: 165aa; similar to SW:P45255 (VPG2_HAEIN) hypothetical protein from Haemophilus influenzae (138 aa) fasta scores; E(): 5.6e-11, 38.4% identity in 164 aa overlap.; hypothetical protein complement(1788210..1788707) Neisseria meningitidis Z2491 907575 YP_002343133.1 CDS NMA1850 NC_003116.1 1788811 1790157 R NMA1850, unknown, len: 448aa; weakly similar to SW:P44226 (YF02_HAEIN) hypothetical protein from Haemophilus influenzae (414 aa) fasta scores; E(): 7.9e-18, 27.3% identity in 362 aa overlap.; hypothetical protein complement(1788811..1790157) Neisseria meningitidis Z2491 907574 YP_002343134.1 CDS NMA1851 NC_003116.1 1790150 1791709 R NMA1851, conserved hypothetical protein, len: 519aa; similar to SW:P44225 (YF01_HAEIN) hypothetical protein from Haemophilus influenzae (520 aa) fasta scores; E(): 0, 46.2% identity in 511 aa overlap.; hypothetical protein complement(1790150..1791709) Neisseria meningitidis Z2491 907573 YP_002343135.1 CDS NMA1852 NC_003116.1 1791788 1793407 R NMA1852, unknown, len: 539aa; hypothetical protein complement(1791788..1793407) Neisseria meningitidis Z2491 907572 YP_002343136.1 CDS NMA1853 NC_003116.1 1793419 1793613 D NMA1853, unknown, len: 64aa; hypothetical protein 1793419..1793613 Neisseria meningitidis Z2491 907571 YP_002343137.1 CDS NMA1854 NC_003116.1 1793610 1794116 R NMA1854, DNA-binding protein, len: 168aa; contains helix-turn-helix motif 21-42aa (+3.63 SD).; hypothetical protein complement(1793610..1794116) Neisseria meningitidis Z2491 907569 YP_002343138.1 CDS NMA1855 NC_003116.1 1794119 1794334 R NMA1855, unknown, len: 71aa; hypothetical protein complement(1794119..1794334) Neisseria meningitidis Z2491 907568 YP_002343139.1 CDS NMA1856 NC_003116.1 1794334 1794615 R NMA1856, unknown, len: 93aa; contains hydrophilic,hydrophobic and coiled-coil regions.; hypothetical protein complement(1794334..1794615) Neisseria meningitidis Z2491 907567 YP_002343140.1 CDS NMA1857 NC_003116.1 1794612 1794953 R NMA1857, unknown, len: 113aa; hypothetical protein complement(1794612..1794953) Neisseria meningitidis Z2491 907566 YP_002343141.1 CDS NMA1858 NC_003116.1 1794950 1795168 R NMA1858, duplicated hypothetical protein, len: 72aa; identical to (but shorter than) another from Neisseria meningitidis NMA1194 fasta scores; E(): 1.8e-32, 100.0% identity in 72 aa overlap.; hypothetical protein complement(1794950..1795168) Neisseria meningitidis Z2491 907565 YP_002343142.1 CDS NMA1859 NC_003116.1 1795181 1795351 D NMA1859, duplicated hypothetical protein, len: 56aa; identical to another from Neisseria meningitidis NMA1193 fasta scores; E(): 6e-26, 100.0% identity in 56 aa overlap.; hypothetical protein 1795181..1795351 Neisseria meningitidis Z2491 907564 YP_002343143.1 CDS NMA1860 NC_003116.1 1795396 1795578 R NMA1860, duplicated hypothetical protein, len: 60aa; almost identical to another from Neisseria meningitidis NMA1192 fasta scores; E(): 8e-26, 98.3% identity in 60 aa overlap.; hypothetical protein complement(1795396..1795578) Neisseria meningitidis Z2491 907562 YP_002343144.1 CDS NMA1861 NC_003116.1 1795598 1796017 R NMA1861, duplicated hypothetical protein, len: aa; identical/almost identical to two others in Neisseria meningitidis; NMA1306 fasta scores; E(): 0, 100.0% identity in 139 aa overlap and NMA1191 fasta scores; E(): 0, 97.1% identity in 139 aa overlap.; hypothetical protein complement(1795598..1796017) Neisseria meningitidis Z2491 907561 YP_002343145.1 CDS NMA1862 NC_003116.1 1795989 1796225 R NMA1862, duplicated hypothetical protein, len: 78aa; identical to two others from Neisseria meningitidis; NMA1190 and NMA1305 fasta scores; E(): 2e-31, 100.0% identity in 78 aa overlap.; hypothetical protein complement(1795989..1796225) Neisseria meningitidis Z2491 907560 YP_002343146.1 CDS NMA1863 NC_003116.1 1796228 1796392 R NMA1863, duplicated hypothetical protein, len: 54aa; identical to two others from Neisseria meningitidis; NMA1189 and NMA1304 fasta scores; E(): 1.7e-22, 100.0% identity in 54 aa overlap.; hypothetical protein complement(1796228..1796392) Neisseria meningitidis Z2491 907559 YP_002343147.1 CDS NMA1864 NC_003116.1 1796598 1797143 R NMA1864, duplicated hypothetical protein, len: 54aa; almost identical to two others from Neisseria meningitidis; NMA1188 and NMA1303 fasta scores; E(): 0,96.7% identity in 181 aa overlap.; hypothetical protein complement(1796598..1797143) Neisseria meningitidis Z2491 907558 YP_002343148.1 CDS NMA1865 NC_003116.1 1797275 1797952 R NMA1865, unknown, len: 225aa; hypothetical protein complement(1797275..1797952) Neisseria meningitidis Z2491 907553 YP_002343149.1 CDS NMA1866 NC_003116.1 1797964 1798410 R NMA1866, integral membrane protein, len: 148aa; contains membrane-spanning hydrophobic region.; integral membrane protein complement(1797964..1798410) Neisseria meningitidis Z2491 907552 YP_002343150.1 CDS NMA1867 NC_003116.1 1798407 1798886 R NMA1867, unknown, len: 159aa; hypothetical protein complement(1798407..1798886) Neisseria meningitidis Z2491 907551 YP_002343151.1 CDS NMA1868 NC_003116.1 1798917 1799192 R NMA1868, hupB2, DNA-binding protein HU-beta, len: 91aa; strongly similar to many eg. SW:P02341 (DBHB_ECOLI) DNA-binding protein HU-beta from Escherichia coli (90 aa) fasta scores; E(): 7.1e-17, 57.8% identity in 90 aa overlap. Contains Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein.; DNA-binding protein HU-beta complement(1798917..1799192) Neisseria meningitidis Z2491 907549 YP_002343152.1 CDS NMA1869 NC_003116.1 1799241 1799441 R NMA1869, unknown, len: 66aa; hypothetical protein complement(1799241..1799441) Neisseria meningitidis Z2491 907548 YP_002343153.1 CDS NMA1870 NC_003116.1 1799442 1800092 R NMA1870, unknown, len: 216aa; hypothetical protein complement(1799442..1800092) Neisseria meningitidis Z2491 907547 YP_002343154.1 CDS NMA1871 NC_003116.1 1800098 1800709 R NMA1871, unknown, len: 203aa; hypothetical protein complement(1800098..1800709) Neisseria meningitidis Z2491 907546 YP_002343155.1 CDS NMA1872 NC_003116.1 1800702 1800896 R NMA1872, unknown, len: 64aa; hypothetical protein complement(1800702..1800896) Neisseria meningitidis Z2491 907545 YP_002343156.1 CDS NMA1873 NC_003116.1 1800868 1801323 R NMA1873, unknown, len: 151aa; hypothetical protein complement(1800868..1801323) Neisseria meningitidis Z2491 907544 YP_002343157.1 CDS NMA1874 NC_003116.1 1801307 1801684 R NMA1874, unknown, len: 125aa; hypothetical protein complement(1801307..1801684) Neisseria meningitidis Z2491 907543 YP_002343158.1 CDS NMA1875 NC_003116.1 1801803 1802117 R NMA1875, unknown, len: 104aa; hypothetical protein complement(1801803..1802117) Neisseria meningitidis Z2491 907542 YP_002343159.1 CDS NMA1876 NC_003116.1 1802114 1802329 R NMA1876, unknown, len: 71aa; hypothetical protein complement(1802114..1802329) Neisseria meningitidis Z2491 907541 YP_002343160.1 CDS NMA1877 NC_003116.1 1802310 1802474 R NMA1877, small secreted protein, len: 54aa; contains a non-cleavable N-terminal signal sequence.; small secreted protein complement(1802310..1802474) Neisseria meningitidis Z2491 907540 YP_002343161.1 CDS NMA1878 NC_003116.1 1802490 1802642 R NMA1878, unknown, len: 50aa; hypothetical protein complement(1802490..1802642) Neisseria meningitidis Z2491 907539 YP_002343162.1 CDS NMA1879 NC_003116.1 1802645 1802944 R NMA1879, unknown, len: 99aa; hypothetical protein complement(1802645..1802944) Neisseria meningitidis Z2491 907538 YP_002343163.1 CDS NMA1880 NC_003116.1 1802934 1803176 R NMA1880, unknown, len: 80aa; hypothetical protein complement(1802934..1803176) Neisseria meningitidis Z2491 907537 YP_002343164.1 CDS NMA1881 NC_003116.1 1803252 1804166 R NMA1881, DNA-binding protein, len: 304aa; similar to SW:P96343 (VPB_HAEIN) cryptic Mu-phage DNA transposition protein from Haemophilus influenzae (287 aa) fasta scores; E(): 2.4e-17, 30.6% identity in 281 aa overlap. Contains helix-turn-helix motif 15-36aa (+6.22 SD).; hypothetical protein complement(1803252..1804166) Neisseria meningitidis Z2491 907536 YP_002343165.1 CDS NMA1882 NC_003116.1 1804208 1806253 R NMA1882, transposase, len: 681aa; similar to TR:Q38013 (EMBL:X87627) transposase from Bacteriophage D3112 of Pseudomonas aeruginosa (690 aa) fasta scores; E(): 3.6e-26, 32.6% identity in 671 aa overlap. Also highly similar to TR:P72094 (EMBL:U56765) transposase homolog (fragment) from Neisseria meningitidis (90 aa) fasta scores; E(): 3.9e-29, 98.9% identity in 90 aa overlap.; transposase complement(1804208..1806253) Neisseria meningitidis Z2491 907535 YP_002343166.1 CDS NMA1883 NC_003116.1 1806331 1806594 R NMA1883, Ner-like DNA-binding protein, len: 87aa; similar to others eg. SW:P06020 (DBNE_BPMU) DNA-binding protein Ner from Bacteriophage Mu (74 aa) fasta scores; E(): 1.2e-10, 51.5% identity in 68 aa overlap. Contains helix-turn-helix motif 25-46aa (+4.35 SD).; Ner-like DNA-binding protein complement(1806331..1806594) Neisseria meningitidis Z2491 907534 YP_002343167.1 CDS NMA1884 NC_003116.1 1806811 1807515 D NMA1884, regulator, len: 234aa; similar to others eg. SW:P14819 (RPC1_BPPH8) repressor protein CI from Bacteriophage phi-80 (235 aa) fasta scores; E(): 4.4e-09, 29.3% identity in 232 aa overlap.; regulator 1806811..1807515 Neisseria meningitidis Z2491 907533 YP_002343168.1 CDS NMA1885 NC_003116.1 1807617 1807775 R NMA1885, unknown, len: 52aa; hypothetical protein complement(1807617..1807775) Neisseria meningitidis Z2491 907532 YP_002343169.1 CDS NMA1886 NC_003116.1 1807779 1810034 R NMA1886, nor, nitric oxide reductase, len: 751aa; similar to many eg. TR:O30368 (EMBL:AF002217) nitric oxide reductase from Alcaligenes eutrophus (762 aa) fasta scores; E(): 0, 61.2% identity in 752 aa overlap. Contains Prosite match to PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature and membrane-spanning hydrophobic regions.; nitric oxide reductase complement(1807779..1810034) Neisseria meningitidis Z2491 907531 YP_002343170.1 CDS NMA1887 NC_003116.1 1810404 1811564 D NMA1887, aniA, nitrite reductase, major outer membrane copper-containing protein, len: 386aa; similar to many egs. SW:Q02219 (ANIA_NEIGO) major outer membrane protein from Neisseria gonorrhoeae (392 aa) fasta scores; E(): 0, 95.7% identity in 392 aa overlap and SW:P25006 (NIR_ACHCY) copper-containing nitrite reductase from Achromobacter cycloclastes (378 aa) fasta scores; E(): 1.2e-17, 36.4% identity in 365 aa overlap. Contains a cleavable N-terminal signal sequence and Pfam match to entry PF00394 Cu-oxidase, Multicopper oxidase and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; nitrite reductase, major outer membrane copper-containing protein 1810404..1811564 Neisseria meningitidis Z2491 907183 YP_002343171.1 CDS NMA1888 NC_003116.1 1811744 1812499 D NMA1888, unknown, len: 251aa; hypothetical protein 1811744..1812499 Neisseria meningitidis Z2491 908134 YP_002343172.1 CDS NMA1891 NC_003116.1 1816250 1816807 R NMA1891, conserved hypothetical protein, len: 185aa; previously sequenced therefore identical to TR:O34773 (EMBL:AF004825) hypothetical protein from Neisseria meningitidis serogroup A (185 aa) fasta scores; E(): 0, 100.0% identity in 185 aa overlap. Also similar to other hypothetical proteins eg. SW:P45244 (YDJA_HAEIN) hypothetical protein from Haemophilus influenzae (184 aa) fasta scores; E(): 0, 50.3% identity in 185 aa overlap.; hypothetical protein complement(1816250..1816807) Neisseria meningitidis Z2491 907529 YP_002343173.1 CDS NMA1892 NC_003116.1 1816883 1818517 R NMA1892, conserved hypothetical protein, len: 544aa; previously sequenced therefore identical to TR:O34609 (EMBL:AF004825) hypothetical protein from Neisseria meningitidis serogroup A (544 aa) fasta scores; E(): 0, 100.0% identity in 544 aa overlap. Also similar to many other hypothetical proteins eg. SW:P30845 (YJDB_ECOLI) hypothetical protein from Escherichia coli (547 aa) fasta scores; E(): 0, 44.2% identity in 547 aa overlap.; hypothetical protein complement(1816883..1818517) Neisseria meningitidis Z2491 906613 YP_002343174.1 CDS serC NC_003116.1 1818798 1819904 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase complement(1818798..1819904) Neisseria meningitidis Z2491 906313 YP_002343175.1 CDS NMA1895 NC_003116.1 1820251 1820700 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 1820251..1820700 Neisseria meningitidis Z2491 907528 YP_002343176.1 CDS nusA NC_003116.1 1820713 1822230 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1820713..1822230 Neisseria meningitidis Z2491 907527 YP_002343177.1 CDS infB NC_003116.1 1822242 1825130 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1822242..1825130 Neisseria meningitidis Z2491 907526 YP_002343178.1 CDS NMA1898 NC_003116.1 1825341 1826735 R NMA1898, integral membrane protein, len: 464aa; N-terminal similar to that of SW:P17196 (EF1A_SULAC) elongation factor 1-alpha from Sulfolobus acidocaldarius (435 aa) fasta scores; E(): 0.25, 31.0% identity in 129 aa overlap. Contains membrane-spanning hydrophobic region.; integral membrane protein complement(1825341..1826735) Neisseria meningitidis Z2491 907525 YP_002343179.1 CDS NMA1899 NC_003116.1 1826797 1828146 R NMA1899, integral membrane protein, len: 449aa; contains membrane-spanning hydrophobic regions.; integral membrane protein complement(1826797..1828146) Neisseria meningitidis Z2491 907524 YP_002343180.1 CDS NMA1900 NC_003116.1 1828289 1828915 D NMA1900, haemolysin, len: 208aa; similar to SW:P54176 (HLY3_BACCE) hemolysin III from Bacillus cereus (219 aa) fasta scores; E(): 4e-30, 42.1% identity in 202 aa overlap. Contains membrane-spanning hydrophobic regions.; hemolysin 1828289..1828915 Neisseria meningitidis Z2491 907522 YP_002343181.1 CDS NMA1901 NC_003116.1 1828979 1830397 R NMA1901, sodium:alanine symporter, len: 472aa; similar to many eg. SW:P30144 (DAGA_ALTHA) Na(+)-linked D-alanine glycine permease (542 aa) fasta scores; E(): 0, 32.6% identity in 537 aa overlap. Contains Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family and Prosite match to PS00873 Sodium:alanine symporter family signature. Also contains membrane-spanning hydrophobic regions.; sodium:alanine symporter complement(1828979..1830397) Neisseria meningitidis Z2491 907521 YP_002343182.1 CDS NMA1902 NC_003116.1 1830724 1831452 D NMA1902, conserved hypothetical protein, len: 242aa; similar to many eg. SW:P24237 (YEBC_ECOLI) hypothetical protein from Escherichia coli (246 aa) fasta scores; E(): 0, 57.7% identity in 234 aa overlap.; hypothetical protein 1830724..1831452 Neisseria meningitidis Z2491 907484 YP_002343183.1 CDS NMA1903 NC_003116.1 1831511 1832110 R NMA1903, disulphide bond formation protein, len: 199aa; similar to many eg. SW:P30018 (DSBB_ECOLI) disulphide bond formation protein B from Escherichia coli (176 aa) fasta scores; E(): 4.2e-08,28.6% identity in 161 aa overlap.; disulfide bond formation protein complement(1831511..1832110) Neisseria meningitidis Z2491 907520 YP_002343184.1 CDS NMA1905 NC_003116.1 1832690 1833154 R NMA1905, AsnC-family transcriptional regulator,len: 154aa; similar to many eg. SW:P19494 (LRP_ECOLI) Lrp leucine-responsive regulatory protein from Escherichia coli (163 aa) fasta scores; E(): 3.7e-31, 56.5% identity in 147 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg, AsnC family.; AsnC family transcriptional regulator complement(1832690..1833154) Neisseria meningitidis Z2491 907518 YP_002343185.1 CDS NMA1906 NC_003116.1 1833479 1834537 D NMA1906, alr, alanine racemase, len: 377aa; similar to many eg. SW:P06655 (ALR1_SALTY) alr, alanine racemase from Salmonella typhimurium (359 aa) fasta scores; E(): 0,41.7% identity in 360 aa overlap. Contains Pfam match to entry PF00842 Ala_racemase, Alanine racemase and Prosite match to PS00395 Alanine racemase pyridoxal-phosphate attachment site.; alanine racemase 1833479..1834537 Neisseria meningitidis Z2491 907517 YP_002343186.1 CDS NMA1908 NC_003116.1 1835999 1837354 R NMA1908, conserved hypothetical protein, len: 451aa; similar to TR:Q59059 (EMBL:U67606) hypothetical protein from Methanococcus jannaschii (458 aa) fasta scores; E(): 0, 62.9% identity in 453 aa overlap.; hypothetical protein complement(1835999..1837354) Neisseria meningitidis Z2491 907514 YP_002343187.1 CDS NMA1909 NC_003116.1 1837369 1837641 R ACT domain-containing protein; hypothetical protein complement(1837369..1837641) Neisseria meningitidis Z2491 907513 YP_002343188.1 CDS NMA1911 NC_003116.1 1837767 1838504 R NMA1911, periplasmic protein, len: 245aa; contains a cleavable N-terminal signal sequence.; hypothetical protein complement(1837767..1838504) Neisseria meningitidis Z2491 907512 YP_002343189.1 CDS NMA1912 NC_003116.1 1838785 1839696 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(1838785..1839696) Neisseria meningitidis Z2491 907511 YP_002343190.1 CDS NMA1913 NC_003116.1 1839829 1840422 D NMA1913, unknown, len: 197aa; hypothetical protein 1839829..1840422 Neisseria meningitidis Z2491 907510 YP_002343191.1 CDS NMA1914 NC_003116.1 1840534 1841154 D NMA1914, unknown, len: 206aa; hypothetical protein 1840534..1841154 Neisseria meningitidis Z2491 907509 YP_002343192.1 CDS NMA1915 NC_003116.1 1841085 1841549 R NMA1915, DNA transport competence protein,len: 154 aa; region of similarity to SW:P39694 (CME1_BACSU) ComE a late competence operon protein from Bacillus subtilis (205 aa) fasta scores; E(): 9.8e-07,47.6% identity in 63 aa overlap. Previously sequenced therefore almost identical to TR:CAB44958 (EMBL:AJ242837) ComEA protein (fragment) from Neisseria meningitidis serogroup A strain Z2491 (170 aa) fasta scores; E(): 0,100.0% identity in 154 aa overlap. Contains Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif and membrane-spanning hydrophobic region. Identical to NMA2187, and almost identical to NMA0211 (98.7% identity in 154 aa overlap), and NMA0423 (98.7% identity in 154 aa overlap); DNA transport competence protein complement(1841085..1841549) Neisseria meningitidis Z2491 907508 YP_002343193.1 CDS NMA1916 NC_003116.1 1847422 1848606 D NMA1916, unknown, len: 394aa; similar to many proposed DNA/pantothenate metabolism flavoproteins eg. SW:P24285 (DFP_ECOLI) from Escherichia coli (430 aa) fasta scores; E(): 0, 39.7% identity in 383 aa overlap.; hypothetical protein 1847422..1848606 Neisseria meningitidis Z2491 907507 YP_002343194.1 CDS NMA1917 NC_003116.1 1848673 1850829 R NMA1917, spoT, guanosine-3',5'-bis(diphosphate) 3'-pyrophophohydrolase, len: 725aa; similar to many eg. SW:P17580 (SPOT_ECOLI) spoT,guanosine-3',5'-bis(diphosphate) 3'-pyrophophohydrolase from Escherichia coli (702 aa) fasta scores; E(): 0, 45.6% identity in 697 aa overlap.; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase complement(1848673..1850829) Neisseria meningitidis Z2491 907506 YP_002343195.1 CDS NMA1918 NC_003116.1 1850922 1851128 R NMA1918, rpoZ, DNA-directed RNA polymerase omega chain, len: 68aa; similar to SW:P08374 (RPOZ_ECOLI) rpoZ,DNA-directed RNA polymerase omega chain from Escherichia coli (91 aa) fasta scores; E(): 3.1e-10, 55.4% identity in 65 aa overlap.; DNA-directed RNA polymerase subunit omega complement(1850922..1851128) Neisseria meningitidis Z2491 907505 YP_002343196.1 CDS gmk NC_003116.1 1851187 1851804 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1851187..1851804) Neisseria meningitidis Z2491 907504 YP_002343197.1 CDS apt NC_003116.1 1851932 1852531 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1851932..1852531 Neisseria meningitidis Z2491 907503 YP_002343198.1 CDS NMA1921 NC_003116.1 1852577 1853386 R NMA1921, conserved hypothetical protein, len: 269aa; similar to many hypothetical proteins eg. TR:Q45494 (EMBL:AF012285) hypothetical protein from Bacillus subtilis (257 aa) fasta scores; E(): 1.7e-25, 32.6% identity in 264 aa overlap. Contains Pfam match to entry PF00592 DUF3, Domain of Unknown Function 3 and Prosite match to PS01229 Hypothetical cof family signature 2.; hypothetical protein complement(1852577..1853386) Neisseria meningitidis Z2491 907186 YP_002343199.1 CDS NMA1923 NC_003116.1 1853690 1855045 D NMA1923, probable protease, len: 451aa; similar to many eg. SW:P76403 (YEGQ_ECOLI) protease from Escherichia coli (453 aa) fasta scores; E(): 0, 60.0% identity in 450 aa overlap. Contains Pfam match to entry PF01136 Peptidase_U32, Peptidase family U32 and Prosite match to PS01276 Peptidase family U32 signature.; protease 1853690..1855045 Neisseria meningitidis Z2491 907502 YP_002343200.1 CDS NMA1924 NC_003116.1 1855179 1855655 D NMA1924, unknown, len: 158aa; hypothetical protein 1855179..1855655 Neisseria meningitidis Z2491 907501 YP_002343201.1 CDS NMA1927 NC_003116.1 1858414 1859106 R NMA1927, hemO, haem utilisation protein, len: 230aa; similar to TR:O69002 (EMBL:AF060193) PigA, iron starvation protein from Pseudomonas aeruginosa (198 aa) fasta scores; E(): 1.3e-20, 37.8% identity in 196 aa overlap. Identified as haem utilisation protein by Zhu et al, J. Bact 182, 439-447 (2000); heme utilisation protein complement(1858414..1859106) Neisseria meningitidis Z2491 906589 YP_002343202.1 CDS NMA1928 NC_003116.1 1859536 1860840 D NMA1928, hypothetical integral membrane protein,len: 434aa; similar to SW:P43670 (PQIA_ECOLI) paraquat-inducible protein from Escherichia coli (417 aa) fasta scores; E(): 0, 31.9% identity in 414 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1859536..1860840 Neisseria meningitidis Z2491 907192 YP_002343203.1 CDS NMA1929 NC_003116.1 1860833 1862494 D NMA1929, hypothetical integral membrane protein,len: 553aa; similar to SW:P43671 (PQIB_ECOLI) paraquat-inducible protein from Escherichia coli (546 aa) fasta scores; E(): 0, 37.0% identity in 549 aa overlap. Contains membrane-spanning hydrophobic regions and a coiled-coil region.; hypothetical protein 1860833..1862494 Neisseria meningitidis Z2491 907188 YP_002343204.1 CDS NMA1930 NC_003116.1 1862494 1863012 D NMA1930, lipoprotein, len: 172aa; similar to SW:P75866 (YMBA_ECOLI) hypothetical protein from Escherichia coli (182 aa) fasta scores; E(): 6.3e-08,30.1% identity in 173 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein 1862494..1863012 Neisseria meningitidis Z2491 907499 YP_002343205.1 CDS NMA1931 NC_003116.1 1863016 1863567 D NMA1931, tag, DNA-3-methyladenine glycosylase I,len: 183aa; similar to many eg. SW:P05100 (3MG1_ECOLI) tag, DNA-3-methyladenine glycosylase I from Escherichia coli (187 aa) fasta scores; E(): 4.1e-13, 39.3% identity in 168 aa overlap.; DNA-3-methyladenine glycosylase I 1863016..1863567 Neisseria meningitidis Z2491 907498 YP_002343206.1 CDS NMA1932 NC_003116.1 1863557 1864198 D NMA1932, lipase, len: 213aa; similar to SW:P29679 (TESA_ECOLI) acyl-CoA thioesterase I from Escherichia coli (208 aa) fasta scores; E(): 1.6e-11,34.9% identity in 172 aa overlap. Contains Pfam match to entry PF00657 Lipase_GDSL, Lipase/Acylhydrolase with GDSL-like motif.; lipase 1863557..1864198 Neisseria meningitidis Z2491 907523 YP_002343207.1 CDS NMA1933 NC_003116.1 1864473 1864832 D NMA1933, integral membrane protein, len: 119aa; contains membrane-spanning hydrophobic regions.; integral membrane protein 1864473..1864832 Neisseria meningitidis Z2491 906035 YP_002343208.1 CDS gcvP NC_003116.1 1864863 1867715 D acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 1864863..1867715 Neisseria meningitidis Z2491 906146 YP_002343209.1 CDS NMA1936 NC_003116.1 1868180 1869019 R NMA1936, probable cytochrome, len: 279aa; regions similar to many smaller cytochromes eg. SW:P00123 (C555_CHLLT) cytochromes c-555 from Chlorobium limicola f.sp. thiosulfatophilum (86 aa) fasta scores; E(): 9.9e-06, 41.3% identity in 80 aa overlap. Contains two Pfam matches to entry PF00034 cytochrome_c, Cytochrome c and two Prosite matches to PS00190 Cytochrome c family heme-binding site signature.; cytochrome complement(1868180..1869019) Neisseria meningitidis Z2491 907496 YP_002343210.1 CDS tyrB NC_003116.1 1869444 1870637 R catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(1869444..1870637) Neisseria meningitidis Z2491 907495 YP_002343211.1 CDS trmA NC_003116.1 1870658 1871746 R catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase complement(1870658..1871746) Neisseria meningitidis Z2491 907494 YP_002343212.1 CDS aroC NC_003116.1 1871893 1872993 D catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1871893..1872993 Neisseria meningitidis Z2491 907493 YP_002343213.1 CDS NMA1940 NC_003116.1 1873085 1873510 D NMA1940, unknown, len: 141aa; hypothetical protein 1873085..1873510 Neisseria meningitidis Z2491 907492 YP_002343214.1 CDS parE NC_003116.1 1873584 1875569 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(1873584..1875569) Neisseria meningitidis Z2491 907491 YP_002343215.1 CDS NMA1942 NC_003116.1 1875636 1876160 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(1875636..1876160) Neisseria meningitidis Z2491 907490 YP_002343216.1 CDS serS NC_003116.1 1876325 1877620 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1876325..1877620 Neisseria meningitidis Z2491 907489 YP_002343217.1 CDS NMA1944 NC_003116.1 1877693 1878691 R NMA1944, ldhA, D-lactate dehydrogenase, len: 332aa; similar to many eg. SW:P52643 (LDHD_ECOLI) ldhA, D-lactate dehydrogenase from Escherichia coli (329 aa) fasta scores; E(): 0, 72.7% identity in 326 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases; Prosite match to PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3; Prosite match to PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2 and Prosite match to PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.; D-lactate dehydrogenase complement(1877693..1878691) Neisseria meningitidis Z2491 907488 YP_002343218.1 CDS prfA NC_003116.1 1878816 1879892 R recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 complement(1878816..1879892) Neisseria meningitidis Z2491 907487 YP_002343219.1 CDS NMA1946 NC_003116.1 1879996 1880850 R NMA1946, conserved hypothetical protein, len: 284aa; note alternative downstream translational start. Similar to many eg. SW:P39408 (YJJV_ECOLI) hypothetical protein from Escherichia coli (259 aa) fasta scores; E(): 4.2e-23, 33.3% identity in 261 aa overlap. Contains Pfam match to entry PF01026 UPF0006,Uncharacterized protein family.; hypothetical protein complement(1879996..1880850) Neisseria meningitidis Z2491 906595 YP_002343220.1 CDS NMA1947 NC_003116.1 1880890 1881879 R NMA1947, ans, L-asparaginase, len: 329aa; similar to many eg. SW:P18840 (ASG1_ECOLI) ansA, L-asparaginase I from Escherichia coli (338 aa) fasta scores; E(): 3.6e-28,32.6% identity in 334 aa overlap. Contains Pfam match to entry PF00710 Asparaginase, Asparaginase; Prosite match to PS00144 Asparaginase / glutaminase active site signature 1 and Prosite match to PS00917 Asparaginase / glutaminase active site signature 2.; L-asparaginase complement(1880890..1881879) Neisseria meningitidis Z2491 906683 YP_002343221.1 CDS NMA1948 NC_003116.1 1881946 1882731 R NMA1948, DedA-family integral membrane protein,len: 261aa; similar to many eg. SW:P45280 (YG29_HAEIN) hypothetical protein from Haemophilus influenzae (212 aa) fasta scores; E(): 0, 58.5% identity in 183 aa overlap. Contains Pfam match to entry PF00597 DedA, DedA family. Also contains membrane-spanning hydrophobic regions.; DedA-family integral membrane protein complement(1881946..1882731) Neisseria meningitidis Z2491 907486 YP_002343222.1 CDS glmM NC_003116.1 1882819 1884153 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1882819..1884153) Neisseria meningitidis Z2491 906601 YP_002343223.1 CDS NMA1950 NC_003116.1 1884283 1885134 R NMA1950, dhpS, dihydropteroate synthase, len: 283aa; similar to many egs. SW:P26282 (DHPS_ECOLI) dhpS,dihydropteroate synthase from Escherichia coli (282 aa) fasta scores; E(): 0, 47.6% identity in 269 aa overlap and SW:Q51161 (DHPS_NEIME) dhpS, dihydropteroate synthase from Neisseria meningitidis (283 aa) fasta scores; E(): 0,91.5% identity in 283 aa overlap. Contains Pfam match to entry PF00809 DHPS, Dihydropteroate synthase and PS00793 Dihydropteroate synthase signature 2.; dihydropteroate synthase complement(1884283..1885134) Neisseria meningitidis Z2491 907184 YP_002343224.1 CDS NMA1951 NC_003116.1 1885301 1887523 D NMA1951, uknown, len: 740aa; similar to SW:U11035 (ASMA_ECOLI) AsmA protein from Escherichia coli (617 aa) fasta scores; E(): 0.0047, 19.0% identity in 695 aa overlap.; hypothetical protein 1885301..1887523 Neisseria meningitidis Z2491 908135 YP_002343225.1 CDS NMA1952 NC_003116.1 1887587 1889065 R NMA1952, conserved hypothetical protein, len: 492aa; similar to many eg. SW:P26615 (YIGC_ECOLI) hypothetical protein from Escherichia coli (497 aa) fasta scores; E(): 0, 71.7% identity in 492 aa overlap.; hypothetical protein complement(1887587..1889065) Neisseria meningitidis Z2491 907483 YP_002343226.1 CDS NMA1953 NC_003116.1 1889085 1889600 R NMA1953, unknown, len: 171aa; hypothetical protein complement(1889085..1889600) Neisseria meningitidis Z2491 907485 YP_002343227.1 CDS NMA1954 NC_003116.1 1889607 1890041 R NMA1954, integral membrane protein, len: 144aa; contains membrane-spanning hydrophobic regions.; integral membrane protein complement(1889607..1890041) Neisseria meningitidis Z2491 907481 YP_002343228.1 CDS NMA1955 NC_003116.1 1890339 1890773 R NMA1955, unknown, len: 144aa; hypothetical protein complement(1890339..1890773) Neisseria meningitidis Z2491 907480 YP_002343229.1 CDS NMA1956 NC_003116.1 1890948 1891616 D NMA1956, insertion element IS1016 transposase, len: 222aa; similar to many eg. TR:Q48208 (EMBL:X58176) insertion sequence IS1016 from Haemophilus influenzae (164 aa) fasta scores; E(): 0, 69.6% identity in 161 aa overlap. Similar to others from Neisseria meningitidis eg. NMA2185, fasta scores; E(): 0, 94.8% identity in 211 aa overlap. Contains helix-turn-helix motif 35-56aa (+4.71 SD).; insertion element IS1016 transposase 1890948..1891616 Neisseria meningitidis Z2491 907479 YP_002343230.1 CDS fabF2 NC_003116.1 1891823 1892959 D FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1891823..1892959 Neisseria meningitidis Z2491 907478 YP_002343231.1 CDS NMA1958 NC_003116.1 1893157 1893921 D NMA1958, lgtF, beta-1,4-glucosyltransferase, len: 254aa; strongly similar to TR:P95373 (EMBL:U58765) lgtF,beta-1,4-glucosyltransferase from Neisseria meningitidis strain CDC8201085; NMB (252 aa) fasta scores; E(): 0,98.4% identity in 252 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases.; beta-1,4-glucosyltransferase 1893157..1893921 Neisseria meningitidis Z2491 907477 YP_002343232.1 CDS NMA1959 NC_003116.1 1893922 1894986 D NMA1959, rfaK, alpha 1,2 N-acetylglucosamine transferase, len: 354aa; strongly similar to TR:Q51123 (EMBL:U58765) rfaK, alpha 1,2 N-acetylglucosamine transferase from Neisseria meningitidis strain CDC8201085; NMB (354 aa) fasta scores; E(): 0, 96.3% identity in 354 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1.; alpha 1,2 N-acetylglucosamine transferase 1893922..1894986 Neisseria meningitidis Z2491 907476 YP_002343233.1 CDS NMA1960 NC_003116.1 1895025 1895195 D NMA1960, unknown, len: 56aa; hypothetical protein 1895025..1895195 Neisseria meningitidis Z2491 907475 YP_002343234.1 CDS NMA1961 NC_003116.1 1895373 1896710 D NMA1961, probable integral membrane ion transporter, len: 445aa; similar to many proposed transporteres eg. TR:AAD20893 (EMBL:U58765) sodium/chroride ion channel from Neisseria meningitidis strain CDC8201085; NMB (445 aa) fasta scores; E(): 0,97.5% identity in 445 aa overlap. Contain two Pfam matches to entry PF00209 SNF, Sodium:neurotransmitter symporter family and membrane-spanning hydrophobic regions.; integral membrane ion transporter 1895373..1896710 Neisseria meningitidis Z2491 907474 YP_002343235.1 CDS NMA1962 NC_003116.1 1896882 1897541 R NMA1962, hypothetical periplasmic protein, len: 219aa; similar to many of undefined function eg. TR:O07332 (EMBL:U94899) NosX protein from Sinorhizobium meliloti (321 aa) fasta scores; E(): 7.4e-25, 50.7% identity in 150 aa overlap. Contains a cleavable N-terminal signal sequence.; hypothetical periplasmic protein complement(1896882..1897541) Neisseria meningitidis Z2491 907473 YP_002343236.1 CDS thyA NC_003116.1 1897550 1898344 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(1897550..1898344) Neisseria meningitidis Z2491 907191 YP_002343237.1 CDS gdhA NC_003116.1 1898767 1900101 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1898767..1900101 Neisseria meningitidis Z2491 907187 YP_002343238.1 CDS NMA1965 NC_003116.1 1900390 1901172 R NMA1965, GntR-family transcriptional regulator,len: 260aa; similar to many eg. SW:P06957 (PDHR_ECOLI) pyruvate dehydrogenase complex repressor from Escherichia coli (254 aa) fasta scores; E(): 2.9e-24, 36.0% identity in 247 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and Prosite match to PS00043 Bacterial regulatory proteins,gntR family signature.; GntR family transcriptional regulator complement(1900390..1901172) Neisseria meningitidis Z2491 907471 YP_002343239.1 CDS NMA1966 NC_003116.1 1901600 1901899 D NMA1966, integral membrane protein, len: 99aa; region similar to regions from lactate permeases eg. SW:P33231 (LLDP_ECOLI) L-lactate permease from Escherichia coli (551 aa) fasta scores; E(): 4.1e-07, 48.6% identity in 70 aa overlap.; integral membrane protein 1901600..1901899 Neisseria meningitidis Z2491 907472 YP_002343240.1 CDS NMA1968 NC_003116.1 1902277 1903680 R NMA1968, mtrE, outer membrane lipoprotein,len: 467aa; similar to many especially TR:Q51006 (EMBL:X95635) implicated in resistance to toxic hydrophobic agents in Neisseria gonorrhoeae (467 aa) fasta scores; E(): 0, 92.1% identity in 467 aa overlap. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and coiled-coil regions.; outer membrane lipoprotein complement(1902277..1903680) Neisseria meningitidis Z2491 907470 YP_002343241.1 CDS NMA1969 NC_003116.1 1903735 1906938 R NMA1969, mtrD, probable drug efflux protein, len: 1067aa; strongly similar to TR:Q51073 (EMBL:U60099) MtrD protein from Neisseria gonorrhoeae (1067 aa) fasta scores; E(): 0, 96.8% identity in 1067 aa overlap and SW:P31224 (ACRB_ECOLI) acriflavin resistance protein from Escherichia coli (1049 aa) fasta scores; E(): 0, 49.4% identity in 1063 aa overlap. Contains Pfam match to entry PF00873 ACR_tran, AcrB/AcrD/AcrF family.; drug efflux protein complement(1903735..1906938) Neisseria meningitidis Z2491 907468 YP_002343242.1 CDS NMA1970 NC_003116.1 1906950 1908188 R NMA1970, mtrC, membrane fusion protein, len: 412aa; strongly similar to many eg. SW:P43505 (MTRC_NEIGO) mtrC,membrane fusion protein from Neisseria gonorrhoeae (412 aa) fasta scores; E(): 0, 96.4% identity in 412 aa overlap and SW:P31223 (ACRA_ECOLI) acriflavin resistance protein from Escherichia coli (397 aa) fasta scores; E(): 0, 42.4% identity in 389 aa overlap. Contains Pfam match to entry PF00529 HlyD, HlyD family secretion protein and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and coiled-coil region.; membrane fusion protein complement(1906950..1908188) Neisseria meningitidis Z2491 907467 YP_002343243.1 CDS NMA1971 NC_003116.1 1908596 1909228 D NMA1971, mtrR, transcriptional regulator, len: 210aa; similar to many eg. SW:P39897 (MTRR_NEIGO) mtrR,transcriptional regulator from Neisseria gonorrhoeae (210 aa) fasta scores; E(): 0, 96.2% identity in 210 aa overlap. Contains Pfam match to entry PF00440 tetR,Bacterial regulatory proteins, tetR family; Prosite match to PS01081 Bacterial regulatory proteins, tetR family signature and helix-turn-helix 32-53aa (+6.17 SD).; transcriptional regulator 1908596..1909228 Neisseria meningitidis Z2491 907469 YP_002343244.1 CDS NMA1972 NC_003116.1 1909507 1909764 R NMA1972, unknown, len: 85aa; hypothetical protein complement(1909507..1909764) Neisseria meningitidis Z2491 907466 YP_002343245.1 CDS NMA1973 NC_003116.1 1910053 1911621 D NMA1973, hypothetical integral membrane protein,len: 522aa; similar to SW:P46133 (YDAH_ECOLI) hypothetical protein from Escherichia coli (510 aa) fasta scores; E(): 0, 38.5% identity in 520 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1910053..1911621 Neisseria meningitidis Z2491 907463 YP_002343246.1 CDS NMA1974 NC_003116.1 1911691 1914900 R NMA1974, recC, exodeoxyribonuclease V, len: 1069aa; similar to SW:P07648 (EX5C_ECOLI) recC,exodeoxyribonuclease V from Escherichia coli (1122 aa) fasta scores; E(): 0, 32.3% identity in 1110 aa overlap.; exodeoxyribonuclease V complement(1911691..1914900) Neisseria meningitidis Z2491 907464 YP_002343247.1 CDS NMA1975 NC_003116.1 1915001 1916410 R NMA1975, integral membrane protein, len: 469aa; contains membrane-spanning hydrophobic regions. Similar to TR:P72122 (EMBL:D28119) outer membrane protein from Pseudomonas aeruginosa (471 aa) fasta scores; E(): 0, 35.8% identity in 480 aa overlap.; integral membrane protein complement(1915001..1916410) Neisseria meningitidis Z2491 907460 YP_002343248.1 CDS NMA1979 NC_003116.1 1918142 1918753 R CcoO; FixO; cbb3-type cytochrome c oxidase subunit II complement(1918142..1918753) Neisseria meningitidis Z2491 907447 YP_002343249.1 CDS NMA1980 NC_003116.1 1918780 1920225 R CcoN; FixN; cbb3-type cytochrome c oxidase subunit I complement(1918780..1920225) Neisseria meningitidis Z2491 907454 YP_002343250.1 CDS NMA1981 NC_003116.1 1920531 1922288 D NMA1981, hypothetical protein, len: 585aa; similar to TR:Q55449 (EMBL:D64006) hypothetical protein from Synechocystis sp. (strain PCC 6803) (584 aa) fasta scores; E(): 0, 34.3% identity in 589 aa overlap.; hypothetical protein 1920531..1922288 Neisseria meningitidis Z2491 907449 YP_002343251.1 CDS NMA1982 NC_003116.1 1922314 1922781 D NMA1982, hypothetical protein, len: 155aa; similar to TR:O33514 (EMBL:U23145) hypothetical protein from Rhodobacter capsulatus (146 aa) fasta scores; E(): 5.7e-11, 34.6% identity in 130 aa overlap.; hypothetical protein 1922314..1922781 Neisseria meningitidis Z2491 907453 YP_002343252.1 CDS NMA1983 NC_003116.1 1923468 1923902 R NMA1983, exbD, biopolymer transport protein, len: 144aa; previously sequenced therefore identical to SW:P95376 (EXBD_NEIME) exbD, biopolymer transport protein from Neisseria meningitidis (144 aa) fasta scores; E(): 0,100.0% identity in 144 aa overlap. Contains membrane-spanning and coiled-coil regions.; biopolymer transport protein complement(1923468..1923902) Neisseria meningitidis Z2491 907458 YP_002343253.1 CDS NMA1984 NC_003116.1 1923905 1924567 R NMA1984, exbB, biopolymer transport protein, len: 220aa; almost identical to SW:P95375 (EXBB_NEIME) exbB,biopolymer transport protein from Neisseria meningitidis (220 aa) fasta scores; E(): 0, 98.6% identity in 220 aa overlap. Contains Pfam match to entry PF01618 MotA_ExbB and membrane-spanning hydrophobic regions.; biopolymer transport protein complement(1923905..1924567) Neisseria meningitidis Z2491 907459 YP_002343254.1 CDS NMA1985 NC_003116.1 1924633 1925475 R NMA1985, tonB, TonB protein, len: 280aa; almost identical to SW:P95374 (TONB_NEIME) TonB protein from Neisseria meningitidis (278 aa) fasta scores; E(): 0,79.7% identity in 281 aa overlap.; TonB protein complement(1924633..1925475) Neisseria meningitidis Z2491 907455 YP_002343255.1 CDS NMA1986 NC_003116.1 1925730 1926368 D NMA1986, conserved hypothetical integral membrane protein, len: 212aa; similar to many eg. TR:O67705 (EMBL:AE000759) hypothetical protein from Aquifex aeolicus (217 aa) fasta scores; E(): 2.1e-15, 41.2% identity in 199 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 1925730..1926368 Neisseria meningitidis Z2491 907452 YP_002343256.1 CDS NMA1988 NC_003116.1 1926820 1927620 R NMA1988, integral membrane protein, len: 266aa; contains membrane-spanning hydrophobic regions.; integral membrane protein complement(1926820..1927620) Neisseria meningitidis Z2491 907451 YP_002343257.1 CDS NMA1989 NC_003116.1 1927756 1928274 R NMA1989, hypothetical integral membrane protein,len: 172aa; similar to two others in this strain: NMA0784 fasta scores; E(): 0, 82.7% identity in 173 aa overlap and NMA0786 fasta scores; E(): 47.6% identity in 168 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein complement(1927756..1928274) Neisseria meningitidis Z2491 907448 YP_002343258.1 CDS grxB NC_003116.1 1928596 1929237 R cofactor involved in the reduction of disulfides; glutaredoxin complement(1928596..1929237) Neisseria meningitidis Z2491 907450 YP_002343259.1 CDS NMA1991 NC_003116.1 1929458 1931767 D NMA1991, relA, GTP pyrophosphokinase, len: 769aa; similar to many eg. SW:P11585 (RELA_ECOLI) relA, GTP pyrophosphokinase from Escherichia coli (744 aa) fasta scores; E(): 0, 41.8% identity in 692 aa overlap.; GTP pyrophosphokinase 1929458..1931767 Neisseria meningitidis Z2491 907446 YP_002343260.1 CDS NMA1994 NC_003116.1 1933011 1934414 R NMA1994, natC, periplasmic type I secretion system protein, len: 467aa; previously sequenced in Neisseria meningitidis therefore almost identical to TR:AAD30978 (EMBL:AF121772) (467 aa) fasta scores; E(): 0,99.8% identity in 467 aa overlap. Also similar to many others eg. SW:P02930 (TOLC_ECOLI) TolC, type I secretion system protein from Escherichia coli (495 aa) fasta scores; E(): 8.8e-23, 27.6% identity in 439 aa overlap. Contains a coiled-ciol region.; periplasmic type I secretion system protein complement(1933011..1934414) Neisseria meningitidis Z2491 907445 YP_002343261.1 CDS NMA1996 NC_003116.1 1934680 1936044 R NMA1996, natD', periplasmic type I secretion system protein, N-terminal region, len: 454aa; previously sequenced in Neisseria meningitidis therefore almost identical to N-terminal region of TR:AAD30977 (EMBL:AF121772) (475 aa) fasta scores; E(): 0, 98.9% identity in 439 aa overlap. Also similar to N-terminal region of SW:P09986 (HLY4_ECOLI) haemolysin secretion protein D from Escherichia coli (478 aa) fasta scores; E(): 0, 38.2% identity in 432 aa overlap. Note CDS is incomplete and may be able to frameshift into the downstream CDS due to the presence of a large tandem repeat between these two CDSs.; periplasmic type I secretion system protein complement(1934680..1936044) Neisseria meningitidis Z2491 907440 YP_002343262.1 CDS NMA1999 NC_003116.1 1937519 1938553 D NMA1999, phage protein, len: 344 aa; shows weak similarity to e.g. TR:O34630 (EMBL:U83796), rstA2,Vibrio cholerae bacteriophage CTXphi protein required for replication and integration (359 aa), fasta scores; E(): 1.5e-09, 27.8% identity in 223 aa overlap. Also similar to TR:O82959 (EMBL:AB015669) ORF C7 from Burkholderia solanacearum plasmid pJTPS1 (444 aa), fasta scores; E(): 1.4e-16, 33.9% identity in 239 aa overlap. Highly similar to others from Neisseria meningitidis e.g. NMA1167, E(): 0, 100.0% identity in 344 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); hypothetical protein 1937519..1938553 Neisseria meningitidis Z2491 907444 YP_002343263.1 CDS NMA2000 NC_003116.1 1938544 1938888 D NMA2000, len: 114 aa; unknown, similar to others from Neisseria meningitidis e.g. NMA1168, fasta scores; E(): 0, 100.0% identity in 114 aa overlap; hypothetical protein 1938544..1938888 Neisseria meningitidis Z2491 907442 YP_002343264.1 CDS NMA2001 NC_003116.1 1938893 1939090 D NMA2001, len: 65 aa; unknown, similar to others from Neisseria meningitidis e.g. NMA1169, fasta scores; E(): 4.2e-27, 100.0% identity in 65 aa overlap; hypothetical protein 1938893..1939090 Neisseria meningitidis Z2491 907439 YP_002343265.1 CDS NMA2002 NC_003116.1 1939098 1939382 D NMA2002, len: 94 aa; unknown, similar to others from Neisseria meningitidis e.g. NMA1170, fasta scores; E(): 0, 100.0% identity in 94 aa overlap; hypothetical protein 1939098..1939382 Neisseria meningitidis Z2491 907438 YP_002343266.1 CDS NMA2003 NC_003116.1 1939389 1939667 D NMA2003, len: 92 aa; unknown, similar to others from Neisseria meningitidis e.g. NMA2003, fasta scores; E(): 0, 100.0% identity in 92 aa overlap; hypothetical protein 1939389..1939667 Neisseria meningitidis Z2491 907437 YP_002343267.1 CDS NMA2004 NC_003116.1 1939780 1940112 D NMA2004, len: 105 aa; similar to others from Neisseria meningitidis e.g. TR:O87782 (EMBL:AJ010115) Neisseria meningitidis strain B:15:P1.16 hypothetical protein (fragment) (148 aa), fasta scores; E(): 1.2e-24,57.3% identity in 110 aa overlap. Also similar to NMA1172,fasta scores; E(): 4e-25 54.8% identity in 104 aa overlap. Lies within a region of unusually low GC content.; hypothetical protein 1939780..1940112 Neisseria meningitidis Z2491 907436 YP_002343268.1 CDS NMA2005 NC_003116.1 1940096 1940491 D NMA2005, probable cell-surface protein, len: 146 aa; highly similar to the N-terminus of TR:O87783 (EMBL:AJ010115), tspB, Neisseria meningitidis strain B:15:P1.16 T-cell and B-cell antigen (partial CDS) (504 aa), fasta scores; E(): 7.3e-25, 84.1% identity in 88 aa overlap. Similar to others from Neisseria meningitidis,e.g. NMA0776, fasta scores; E(): 1.9e-20, 61.5% identity in 96 aa overlap, and NMA1797 fasta scores; E(): 7.8e-23,68.0% identity in 97 aa overlap, (both tspB genes) and NMA1173 fasta scores; E(): 2.9e-30, 66.2% identity in 133 aa overlap (another cell-surface protein). N-terminal half has low GC content. Contains a probable N-terminal signal sequence; cell-surface protein 1940096..1940491 Neisseria meningitidis Z2491 907435 YP_002343269.1 CDS NMA2006 NC_003116.1 1941209 1941568 R NMA2006, conserved hypothetical protein, len: 119aa; similar to many eg. TR:O67700 (EMBL:AE000759) hypothetical protein from Aquifex aeolicus (117 aa) fasta scores; E(): 3.6e-15, 42.0% identity in 112 aa overlap.; hypothetical protein complement(1941209..1941568) Neisseria meningitidis Z2491 907434 YP_002343270.1 CDS NMA2007 NC_003116.1 1941591 1942235 R NMA2007, unknown, len: 214aa; hypothetical protein complement(1941591..1942235) Neisseria meningitidis Z2491 907433 YP_002343271.1 CDS NMA2008 NC_003116.1 1942237 1942773 R NMA2008, conserved hypothetical protein, len: 178aa; similar to many eg. TR:O67698 (EMBL:AE000759) hypothetical protein from Aquifex aeolicus (186 aa) fasta scores; E(): 1.2e-16, 34.6% identity in 179 aa overlap.; hypothetical protein complement(1942237..1942773) Neisseria meningitidis Z2491 907432 YP_002343272.1 CDS NMA2009 NC_003116.1 1942785 1943882 R NMA2009, unknown, len: 365aa; hypothetical protein complement(1942785..1943882) Neisseria meningitidis Z2491 907431 YP_002343273.1 CDS NMA2010 NC_003116.1 1943885 1945276 R NMA2010, hypothetical protein, len: 463aa; weakly similar to TR:Q56292 (EMBL:L18975) hypothetical protein from Thiobacillus ferrooxidans (318 aa) fasta scores; E(): 0.86, 24.6% identity in 349 aa overlap.; hypothetical protein complement(1943885..1945276) Neisseria meningitidis Z2491 907430 YP_002343274.1 CDS NMA2011 NC_003116.1 1945541 1946323 R NMA2011, conserved hypothetical protein, len: 264aa; highly similar to SW:P45249 (BIOC_HAEIN) biotin synthesis protein from Haemophilus influenzae (260 aa) fasta scores; E(): 0, 92.2% identity in 255 aa overlap. Also weakly similar to SW:P12999 (BIOC_ECOLI) biotin synthesis protein from Escherichia coli (251 aa) fasta scores; E(): 1.8e-07, 25.9% identity in 259 aa overlap.; hypothetical protein complement(1945541..1946323) Neisseria meningitidis Z2491 907429 YP_002343275.1 CDS NMA2012 NC_003116.1 1946311 1946958 R NMA2012, conserved hypothetical protein, len: 215aa; highly similar to SW:P44251 (YF52_HAEIN) hypothetical protein from Haemophilus influenzae (215 aa) fasta scores; E(): 0, 86.0% identity in 215 aa overlap.; hypothetical protein complement(1946311..1946958) Neisseria meningitidis Z2491 907428 YP_002343276.1 CDS bioF NC_003116.1 1946968 1948110 R catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase complement(1946968..1948110) Neisseria meningitidis Z2491 907427 YP_002343277.1 CDS NMA2014 NC_003116.1 1948333 1949409 D NMA2014, unknown, len: 358aa; hypothetical protein 1948333..1949409 Neisseria meningitidis Z2491 907426 YP_002343278.1 CDS NMA2015 NC_003116.1 1949616 1951082 R NMA2015, integral membrane transport protein, len: 488aa; similar to many eg. SW:Q41364 (SOT1_SPIOL) 2-oxoglutarate/malate translocator from Spinacia oleracea (Spinach) (569 aa) fasta scores; E(): 0,44.2% identity in 480 aa overlap. Contains Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region and several membrane-spanning hydrophobic regions.; integral membrane transport protein complement(1949616..1951082) Neisseria meningitidis Z2491 907425 YP_002343279.1 CDS speB NC_003116.1 1951280 1952203 R catalyzes the formation of putrescine from agmatine; agmatinase complement(1951280..1952203) Neisseria meningitidis Z2491 907424 YP_002343280.1 CDS speA NC_003116.1 1952302 1954194 R catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase complement(1952302..1954194) Neisseria meningitidis Z2491 907423 YP_002343281.1 CDS NMA2018 NC_003116.1 1954361 1954645 R NMA2018, hypothetical periplasmic protein, len: 94aa; cContains a cleavable N-terminal signal sequence.; hypothetical periplasmic protein complement(1954361..1954645) Neisseria meningitidis Z2491 907422 YP_002343282.1 CDS aspS NC_003116.1 1954796 1956604 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1954796..1956604) Neisseria meningitidis Z2491 907421 YP_002343283.1 CDS NMA2020 NC_003116.1 1956662 1957399 R NMA2020, integral membrane protein, len: 245aa; similar to TR:Q9Z846 (EMBL:AE001635) hypothetical protein from Chlamydia pneumoniae (223 aa) fasta scores; E(): 1.5e-21, 31.8% identity in 220 aa overlap. Contains membrane-spanning hydrophobic regions.; integral membrane protein complement(1956662..1957399) Neisseria meningitidis Z2491 907420 YP_002343284.1 CDS NMA2021 NC_003116.1 1957506 1958735 R NMA2021, phopholipase, len: 409aa; similar to, but longer than, many eg. SW:P00631 (PA1_ECOLI) phopholipase A1 from Escherichia coli (289 aa) fasta scores; E(): 1.3e-25, 37.5% identity in 256 aa overlap. Note alternative translational start sites downstream.; phopholipase complement(1957506..1958735) Neisseria meningitidis Z2491 907419 YP_002343285.1 CDS rpsT NC_003116.1 1958814 1959077 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(1958814..1959077) Neisseria meningitidis Z2491 907418 YP_002343286.1 CDS NMA2023 NC_003116.1 1959380 1960522 D NMA2023, polyamine permease substrate-binding protein, len: 407aa; similar to many eg. SW:P31133 (POTF_ECOLI) putrescine-binding periplasmic protein (370 aa) fasta scores; E(): 0, 38.9% identity in 352 aa overlap. Also similar to NMA0831 (fasta scores; E(): 0, 54.8% identity in 396 aa overlap) and NMA2023 fasta scores; (E(): 0, 55.2% identity in 377 aa overlap) from Neisseria meningitidis. Contains a cleavable N-terminal signal sequence.; polyamine permease substrate-binding protein 1959380..1960522 Neisseria meningitidis Z2491 907417 YP_002343287.1 CDS NMA2024 NC_003116.1 1962649 1965381 R NMA2024, tbpA, transferrin-binding protein A, len: 910aa; previously sequenced therefore identical to TR:Q53348 (EMBL:AF058689). Contains Pfam match to entry PF00593 TonB_boxC, TonB dependent receptor C-terminal region and Prosite match to PS01156 TonB-dependent receptor proteins signature 2.; transferrin-binding protein A complement(1962649..1965381) Neisseria meningitidis Z2491 907416 YP_002343288.1 CDS NMA2025 NC_003116.1 1965468 1967564 R NMA2025, tbpB, transferrin-binding protein B, len: 698aa; previously sequenced therefore identical to TR:O68937 (EMBL:AF058689). Contains Pfam match to entry PF01298 Lipoprotein_5, Transferrin binding protein and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; transferrin-binding protein B complement(1965468..1967564) Neisseria meningitidis Z2491 907415 YP_002343289.1 CDS glr NC_003116.1 1969683 1970495 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(1969683..1970495) Neisseria meningitidis Z2491 907414 YP_002343290.1 CDS NMA2027 NC_003116.1 1970697 1971158 D NMA2027, conserved hypothetical protein, len: 153aa; similar to many eg. SW:P31805 (YJEE_ECOLI) hypothetical protein from Escherichia coli (153 aa) fasta scores; E(): 9.3e-26, 48.9% identity in 137 aa overlap.; hypothetical protein 1970697..1971158 Neisseria meningitidis Z2491 907413 YP_002343291.1 CDS NMA2028 NC_003116.1 1971155 1972405 D NMA2028, amiC, N-acetylmuramoyl-L-alanine amidase,len: 416aa; similar to many eg. SW:Q46929 (AMIC_ECOLI) amiC, N-acetylmuramoyl-L-alanine amidase from Escherichia coli (417 aa) fasta scores; E(): 0, 51.1% identity in 425 aa overlap. Contains Pfam match to entry PF01520 Amidase_3.; N-acetylmuramoyl-L-alanine amidase 1971155..1972405 Neisseria meningitidis Z2491 907412 YP_002343292.1 CDS NMA2029 NC_003116.1 1972431 1973303 D NMA2029, unknown, len: 290aa; hypothetical protein 1972431..1973303 Neisseria meningitidis Z2491 907411 YP_002343293.1 CDS NMA2030 NC_003116.1 1973599 1974741 R NMA2030, conserved hypothetical protein, len: 380aa; similar to the N-terminal half of many hypothetical proteins eg. SW:P75864 (YCBY_ECOLI) hypothetical protein from Escherichia coli (702 aa) fasta scores; E(): 0, 37.9% identity in 372 aa overlap. Also similar and equal in length to many others eg. SW:Q55156 (Y064_SYNY3) hypothetical protein from Synechocystis sp. (strain PCC 6803) (384 aa) fasta scores; E(): 0, 34.8% identity in 374 aa overlap. Contains Pfam match to entry PF01170 UPF0020,Uncharacterized protein family UPF0020 and Prosite match to PS01261 Uncharacterized protein family UPF0020 signature.; hypothetical protein complement(1973599..1974741) Neisseria meningitidis Z2491 907410 YP_002343294.1 CDS NMA2031 NC_003116.1 1974790 1975212 R NMA2031, secreted protein, len: 140aa; contains a cleavable N-terminal signal sequence.; secreted protein complement(1974790..1975212) Neisseria meningitidis Z2491 907409 YP_002343295.1 CDS NMA2032 NC_003116.1 1975205 1976014 R NMA2032, MutT-related protein, len: 269aa; similar to but larger than many MutT homlogs eg. SW:P44932 (MUTT_HAEIN) MutT protein from Haemophilus influenzae (136 aa) fasta scores; E(): 3.5e-13, 40.6% identity in 128 aa overlap. Contains Pfam match to entry PF00293 mutT,Bacterial mutT protein and Prosite match to PS00893 mutT domain signature.; MutT-like protein complement(1975205..1976014) Neisseria meningitidis Z2491 907408 YP_002343296.1 CDS acpS NC_003116.1 1976091 1976468 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1976091..1976468) Neisseria meningitidis Z2491 907407 YP_002343297.1 CDS NMA2035 NC_003116.1 1976669 1977436 R NMA2035, conserved hypothetical protein, len: 255aa; weakly similar to many eg. TR:O66527 (EMBL:AE000675) hypothetical protein from Aquifex aeolicus (272 aa) fasta scores; E(): 0.0001, 24.6% identity in 256 aa overlap. Lies in a region of unusually low GC content.; hypothetical protein complement(1976669..1977436) Neisseria meningitidis Z2491 907405 YP_002343298.1 CDS NMA2036 NC_003116.1 1977446 1978225 R NMA2036, unknown, len: 259aa; Lies in a region of unusually low GC content.; hypothetical protein complement(1977446..1978225) Neisseria meningitidis Z2491 907404 YP_002343299.1 CDS pdxJ NC_003116.1 1978272 1979000 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(1978272..1979000) Neisseria meningitidis Z2491 907403 YP_002343300.1 CDS NMA2038 NC_003116.1 1979024 1979818 R NMA2038, recO, DNA repair protein (recombination protein o), len: aa; similar to many eg. TR:Q9ZHY2 (EMBL:AF047375) RecO protein from Neisseria gonorrhoeae (247 aa) fasta scores; E(): 0, 80.7% identity in 244 aa overlap.; DNA repair protein (recombination protein o) complement(1979024..1979818) Neisseria meningitidis Z2491 907402 YP_002343301.1 CDS NMA2039 NC_003116.1 1979849 1980976 R NMA2039, pheA, chorismate mutase, len: 375aa; similar to many egs. TR:Q9ZHY3 (EMBL:AF047375) PheA from Neisseria gonorrhoeae (375 aa) fasta scores; E(): 0, 98.7% identity in 375 aa overlap and SW:P27603 (PHEA_PSEST) chorismate mutase from Pseudomonas stutzeri (365 aa) fasta scores; E(): 0, 50.4% identity in 357 aa overlap. Contains Pfam match to entry PF00800 PDT, Prephenate dehydratase and Prosite match to PS00857 Prephenate dehydratase signature 1.; chorismate mutase complement(1979849..1980976) Neisseria meningitidis Z2491 907401 YP_002343302.1 CDS NMA2040 NC_003116.1 1981015 1982247 R NMA2040, integral membrane efflux protein,len: 410aa; similar to many eg. SW:P28246 (BCR_ECOLI) bicyclomycin resistance protein from Escherichia coli (396 aa) fasta scores; E(): 0, 29.0% identity in 386 aa overlap. Contains membrane-spanning hydrophobic regions.; integral membrane efflux protein complement(1981015..1982247) Neisseria meningitidis Z2491 907400 YP_002343303.1 CDS NMA2041 NC_003116.1 1982766 1983620 R NMA2041, conserved hypothetical protein, len: 284aa; similar to many hypothetical protein, some of which occur as two seperate CDSs ie. N-terminal region similar to SW:Q57147 (Y976_HAEIN) hypothetical protein from Haemophilus influenzae (128 aa) fasta scores; E(): 1.1e-18, 53.5% identity in 114 aa overlap; C-terminal region similar to SW:O86230 (Y97X_HAEIN) hypothetical protein from Haemophilus influenzae (170 aa) fasta scores; E(): 8.9e-27, 48.1% identity in 156 aa overlap. Contains a Pfam match to entry PF00892 DUF6, Integral membrane protein in both the N and C-terminal regions.; hypothetical protein complement(1982766..1983620) Neisseria meningitidis Z2491 907399 YP_002343304.1 CDS NMA2044 NC_003116.1 1987822 1988634 R NMA2044, conserved hypothetical protein, len: 270aa; similar to SW:P55175 (Y601_SYNY3) hypothetical protein from Synechocystis sp. (strain PCC 6803) (272 aa) fasta scores; E(): 0, 40.4% identity in 275 aa overlap.; hypothetical protein complement(1987822..1988634) Neisseria meningitidis Z2491 907397 YP_002343305.1 CDS NMA2045 NC_003116.1 1988719 1989591 D NMA2045, oxidoreductase, len: 290aa; similar to many eg. SW:P20692 (TYRA_BACSU) prephenate dehydrogenase from Bacillus subtilis (372 aa) fasta scores; E(): 2.8e-30, 39.4% identity in 284 aa overlap.; oxidoreductase 1988719..1989591 Neisseria meningitidis Z2491 907396 YP_002343306.1 CDS NMA2046 NC_003116.1 1989648 1990850 R NMA2046, hypothetical integral membrane protein,len: 400aa; similar to TR:P95556 (EMBL:Z73914) hypothetical protein from Pseudomonas stutzeri (396 aa) fasta scores; E(): 0, 35.0% identity in 391 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein complement(1989648..1990850) Neisseria meningitidis Z2491 907395 YP_002343307.1 CDS NMA2047 NC_003116.1 1990847 1991215 R NMA2047, hypothetical protein, len: 122aa; weakly similar to SW:P71932 (YQ03_MYCTU) hypothetical protein from Mycobacterium tuberculosis (161 aa) fasta scores; E(): 0.017, 32.5% identity in 117 aa overlap.; hypothetical protein complement(1990847..1991215) Neisseria meningitidis Z2491 907394 YP_002343308.1 CDS NMA2048 NC_003116.1 1991389 1991832 D NMA2048, conserved hypothetical protein, len: 147aa; similar to many eg. SW:P21498 (YJEB_ECOLI) hypothetical protein from Escherichia coli (141 aa) fasta scores; E(): 5.9e-23, 47.9% identity in 140 aa overlap.; hypothetical protein 1991389..1991832 Neisseria meningitidis Z2491 907393 YP_002343309.1 CDS NMA2049 NC_003116.1 1991959 1992579 R NMA2049, conserved hypothetical protein, len: 206aa; similar to many eg. SW:P45847 (YCIO_ECOLI) hypothetical protein from Escherichia coli (206 aa) fasta scores; E(): 0, 62.9% identity in 205 aa overlap. Contains Pfam match to entry PF01300 Sua5_yciO_yrdC, SUA5/yciO/yrdC family and Prosite match to PS01147 SUA5/yciO/yrdC family signature.; hypothetical protein complement(1991959..1992579) Neisseria meningitidis Z2491 907392 YP_002343310.1 CDS ackA2 NC_003116.1 1992937 1994136 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(1992937..1994136) Neisseria meningitidis Z2491 907391 YP_002343311.1 CDS NMA2051 NC_003116.1 1994550 1995719 R NMA2051, conserved hypothetical protein, len: 389aa; similar to SW:O07931 (YRAM_BACSU) hypothetical protein from Bacillus subtilis (367 aa) fasta scores; E(): 0, 37.1% identity in 385 aa overlap.; hypothetical protein complement(1994550..1995719) Neisseria meningitidis Z2491 907390 YP_002343312.1 CDS acnA NC_003116.1 1996523 1999129 R Catalyzes the conversion of citrate to isocitrate; aconitate hydratase complement(1996523..1999129) Neisseria meningitidis Z2491 907389 YP_002343313.1 CDS NMA2053 NC_003116.1 1999207 1999995 R NMA2053, conserved hypothetical integral membrane protein, len: 262aa; similar to many eg. SW:P29942 (YCB9_PSEDE) hypothetical protein from Pseudomonas denitrificans (261 aa) fasta scores; E(): 0, 48.4% identity in 256 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein complement(1999207..1999995) Neisseria meningitidis Z2491 907388 YP_002343314.1 CDS prpC NC_003116.1 2000156 2001310 R catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase complement(2000156..2001310) Neisseria meningitidis Z2491 907387 YP_002343315.1 CDS prpB NC_003116.1 2001396 2002274 R catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase complement(2001396..2002274) Neisseria meningitidis Z2491 907386 YP_002343316.1 CDS NMA2056 NC_003116.1 2002897 2004207 R NMA2056, conserved hypothetical protein, len: 436aa; similar to many eg. SW:Q57772 (Y326_METJA) hypothetical protein from Methanococcus jannaschii (436 aa) fasta scores; E(): 0, 50.5% identity in 430 aa overlap. Contains Pfam match to entry PF00860 xan_ur_permease, Xanthine/uracil permeases family.; hypothetical protein complement(2002897..2004207) Neisseria meningitidis Z2491 907385 YP_002343317.1 CDS ftsZ NC_003116.1 2004346 2005524 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(2004346..2005524) Neisseria meningitidis Z2491 907384 YP_002343318.1 CDS NMA2058 NC_003116.1 2005643 2006887 R NMA2058, ftsA, cell division protein, len: 414aa; strongly similar to many eg. SW:P06137 (FTSA_ECOLI) ftsA,cell division protein from Escherichia coli (420 aa) fasta scores; E(): 0, 41.9% identity in 420 aa overlap.; cell division protein complement(2005643..2006887) Neisseria meningitidis Z2491 907383 YP_002343319.1 CDS NMA2059 NC_003116.1 2006973 2007701 R NMA2059, ftsQ, cell division protein, len: 242aa; similar to many eg. SW:P06136 (FTSQ_ECOLI) ftsQ, cell division protein from Escherichia coli (276 aa) fasta scores; E(): 9.1e-26, 34.7% identity in 239 aa overlap.; cell division protein complement(2006973..2007701) Neisseria meningitidis Z2491 907382 YP_002343320.1 CDS ddl NC_003116.1 2007691 2008605 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase complement(2007691..2008605) Neisseria meningitidis Z2491 907381 YP_002343321.1 CDS murC NC_003116.1 2008718 2010124 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(2008718..2010124) Neisseria meningitidis Z2491 907380 YP_002343322.1 CDS murG NC_003116.1 2010282 2011349 R UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase complement(2010282..2011349) Neisseria meningitidis Z2491 907379 YP_002343323.1 CDS NMA2063 NC_003116.1 2011353 2012660 R NMA2063, ftsW, cell division protein, len: 435aa; similar to many eg. SW:P16457 (FTSW_ECOLI) ftsW, cell division protein from Escherichia coli (414 aa) fasta scores; E(): 0, 39.3% identity in 394 aa overlap. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein and Prosite match to PS00428 Cell cycle proteins ftsW / rodA / spoVE signature.; cell division protein complement(2011353..2012660) Neisseria meningitidis Z2491 907378 YP_002343324.1 CDS murD NC_003116.1 2012804 2014141 R UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase complement(2012804..2014141) Neisseria meningitidis Z2491 907377 YP_002343325.1 CDS NMA2065 NC_003116.1 2014226 2014498 R NMA2065, periplasmic protein, len: 90aa; contains a cleavable N-terminal signal sequence.; hypothetical protein complement(2014226..2014498) Neisseria meningitidis Z2491 907376 YP_002343326.1 CDS mraY NC_003116.1 2014613 2015695 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(2014613..2015695) Neisseria meningitidis Z2491 907375 YP_002343327.1 CDS NMA2067 NC_003116.1 2015789 2015971 R NMA2067, periplasmic protein, len: 60aa; contains a cleavable N-terminal signal sequence.; hypothetical protein complement(2015789..2015971) Neisseria meningitidis Z2491 907374 YP_002343328.1 CDS NMA2068 NC_003116.1 2015968 2017326 R NMA2068, murF, UDP-MurNAc-pentapeptide synthetase,len: 452aa; similar to many eg. SW:P11880 (MURF_ECOLI) murF, UDP-MurNAc-pentapeptide synthetase from Escherichia coli (452 aa) fasta scores; E(): 0, 41.0% identity in 456 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family.; UDP-MurNAc-pentapeptide synthetase complement(2015968..2017326) Neisseria meningitidis Z2491 907373 YP_002343329.1 CDS murE NC_003116.1 2019121 2020599 R involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase complement(2019121..2020599) Neisseria meningitidis Z2491 907371 YP_002343330.1 CDS NMA2072 NC_003116.1 2020624 2022369 R NMA2072, penA, penicillin-binding protein 2, len: 581aa; highly similar to many from Neisseria. Identical to SW:P11882 (PBP2_NEIME) from Neisseria meningitidis (581 aa). Contains Pfam match to entry PF00905 Transpeptidase,Penicillin binding protein transpeptidase domain.; penicillin-binding protein 2 complement(2020624..2022369) Neisseria meningitidis Z2491 907370 YP_002343331.1 CDS NMA2073 NC_003116.1 2022430 2022699 R NMA2073, small periplasmic protein, len: 89aa; contains a cleavable N-terminal signal sequence.; small periplasmic protein complement(2022430..2022699) Neisseria meningitidis Z2491 907369 YP_002343332.1 CDS mraW NC_003116.1 2022690 2023676 R NMA2074, conserved hypothetical protein, len: aa; similar to many eg. SW:P18595 (YABC_ECOLI) hypothetical protein from Escherichia coli (313 aa) fasta scores; E(): 0, 53.3% identity in 315 aa overlap.; S-adenosyl-methyltransferase MraW complement(2022690..2023676) Neisseria meningitidis Z2491 907368 YP_002343333.1 CDS NMA2075 NC_003116.1 2023673 2024128 R MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ complement(2023673..2024128) Neisseria meningitidis Z2491 907367 YP_002343334.1 CDS NMA2076 NC_003116.1 2024407 2025624 D NMA2076, conserved hypothetical protein, len: 405aa; similar to many eg. TR:Q57456 (EMBL:D64000) hypothetical protein from Synechocystis sp. (strain PCC 6803) (416 aa) fasta scores; E(): 0, 33.2% identity in 371 aa overlap. Note alternative downstream start codons.; hypothetical protein 2024407..2025624 Neisseria meningitidis Z2491 907366 YP_002343335.1 CDS NMA2077 NC_003116.1 2026199 2027020 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase complement(2026199..2027020) Neisseria meningitidis Z2491 907365 YP_002343336.1 CDS NMA2078 NC_003116.1 2027053 2027697 R NMA2078, thiol:disulphide interchange protein, len: 214aa; weakly similar to many eg. SW:P95460 (DSBA_PSEAE) DsbA, proposed thiol:disulphide interchange protein from Pseudomonas aeruginosa (210 aa) fasta scores; E(): 2.1e-16, 33.5% identity in 203 aa overlap. Contains Pfam match to entry PF01323 DSBA, DSBA oxidoreductase and Prosite match to PS00194 Thioredoxin family active site. Contains a cleavable N-terminal signal sequence.; thiol:disulfide interchange protein complement(2027053..2027697) Neisseria meningitidis Z2491 907364 YP_002343337.1 CDS NMA2079 NC_003116.1 2027700 2028569 R NMA2079, hypothetical lysine-rich membrane protein,len: 289aa; contains a non-cleavable N-terminal signal sequence.; hypothetical protein complement(2027700..2028569) Neisseria meningitidis Z2491 907363 YP_002343338.1 CDS NMA2080 NC_003116.1 2028669 2030165 R NMA2080, chelatase, len: 498aa; similar to many eg. SW:P45049 (YIFB_HAEIN) hypothetical protein from Haemophilus influenzae (509 aa) fasta scores; E(): 0,50.0% identity in 500 aa overlap. Contains Pfam match to entry PF01078 Mg_chelatase, Magnesium chelatase, subunit ChlI.; chelatase complement(2028669..2030165) Neisseria meningitidis Z2491 907362 YP_002343339.1 CDS NMA2081 NC_003116.1 2030179 2030532 R NMA2081, hypothetical protein, len: 117aa; N-terminal region similar to SW:Q46868 (YQIC_ECOLI) hypothetical protein from Escherichia coli (116 aa) fasta scores; E(): 2.7e-06, 40.7% identity in 81 aa overlap. Contains coiled-coil region.; hypothetical protein complement(2030179..2030532) Neisseria meningitidis Z2491 907361 YP_002343340.1 CDS NMA2083 NC_003116.1 2030982 2032508 D NMA2083, putP, sodium/proline symporter, len: 508aa; strongly similar to many eg. SW:P07117 (PUTP_ECOLI) putP, sodium/proline symporter from Escherichia coli (502 aa) fasta scores; E(): 0, 64.1% identity in 504 aa overlap. Contains Pfam match to entry PF00474 SSF,Sodium:solute symporter family, Prosite match to PS00456 Sodium:solute symporter family signature 1 and Prosite match to PS00457 Sodium:solute symporter family signature 2.; sodium/proline symporter 2030982..2032508 Neisseria meningitidis Z2491 907360 YP_002343341.1 CDS putA NC_003116.1 2032759 2036364 D proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 2032759..2036364 Neisseria meningitidis Z2491 907359 YP_002343342.1 CDS NMA2086 NC_003116.1 2039124 2039894 R NMA2086, xthA, exodeoxyribonuclease III, len: 256aa; similar to many eg. SW:P09030 (EX3_ECOLI) xthA,exodeoxyribonuclease III from Escherichia coli (268 aa) fasta scores; E(): 1.6e-17, 36.5% identity in 266 aa overlap. Contains Pfam match to entry PF01260 AP_endonucleas1, AP endonuclease family 1 and Prosite match to PS00726 AP endonucleases family 1 signature 1.; exodeoxyribonuclease III complement(2039124..2039894) Neisseria meningitidis Z2491 907357 YP_002343343.1 CDS NMA2088 NC_003116.1 2040486 2041367 R NMA2088, nadC, nicotinate-nucleotide pyrophosphorylase, len: 293aa; similar to many eg. SW:O06594 (NADC_MYCTU) nadC, nicotinate-nucleotide pyrophosphorylase from Mycobacterium tuberculosis (285 aa) fasta scores; E(): 0, 45.5% identity in 277 aa overlap.; nicotinate-nucleotide pyrophosphorylase complement(2040486..2041367) Neisseria meningitidis Z2491 907355 YP_002343344.1 CDS NMA2089 NC_003116.1 2041596 2042534 R NMA2089, cytoplasmic membrane protein,len: 312aa; contains a non-cleavable N-terminal signal sequence. Region around 200-300aa similar to region in several hypothetical proteins eg. TR:P74291 (EMBL:D90913) from Synechocystis sp. strain PCC6803 (261 aa) fasta scores; E(): 1.7e-05, 27.1% identity in 129 aa overlap.; cytoplasmic membrane protein complement(2041596..2042534) Neisseria meningitidis Z2491 907354 YP_002343345.1 CDS nadA NC_003116.1 2042839 2043951 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 2042839..2043951 Neisseria meningitidis Z2491 907353 YP_002343346.1 CDS NMA2091 NC_003116.1 2044102 2044437 D NMA2091, integral membrane drug resistance protein, len: 111aa; strongly similar to many drug resistance proteins eg. SW:P14319 (EBR_STAAU) ethidium bromide resistance protein from Staphylococcus aureus (107 aa) fasta scores; E(): 2.5e-17, 53.5% identity in 101 aa overlap. Contains Pfam match to entry PF00893 DUF7,Integral membrane protein.; integral membrane drug resistance protein 2044102..2044437 Neisseria meningitidis Z2491 907352 YP_002343347.1 CDS NMA2092 NC_003116.1 2044486 2045994 D NMA2092, nadB, L-aspartate oxidase, len: 502aa; similar to many eg. SW:P38032 (NADB_BACSU) nadB,L-aspartate oxidase from Bacillus subtilis (531 aa) fasta scores; E(): 0, 37.3% identity in 507 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain.; L-aspartate oxidase 2044486..2045994 Neisseria meningitidis Z2491 907351 YP_002343348.1 CDS NMA2093 NC_003116.1 2046172 2046837 R NMA2093, pgm2, beta-phosphoglucomutase, len: 221aa; similar to many eg. SW:P71447 (PGMB_LACLA) pgmB,beta-phosphoglucomutase from Lactococcus lactis (subsp. lactis) (221 aa) fasta scores; E(): 0, 68.2% identity in 220 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. Highly similar to the neighbouring gene NMA2097 (fasta scores; E(): 0, 95.9% identity in 221 aa overlap) indicating a duplication event.; beta-phosphoglucomutase complement(2046172..2046837) Neisseria meningitidis Z2491 907350 YP_002343349.1 CDS NMA2095 NC_003116.1 2047183 2048235 R NMA2095, integral membrane efflux protein,len: 350aa; similar to SW:P74311 (Y944_SYNY3) hypothetical protein from Synechocystis sp. (strain PCC 6803) (383 aa) fasta scores; E(): 0, 44.4% identity in 342 aa overlap. Weakly similar to SW:Q06598 (ACR3_YEAST) arsenical resistance protein from Saccharomyces cerevisiae (Baker's yeast) (404 aa) fasta scores; E(): 2.2e-13, 26.4% identity in 382 aa overlap. Lies in a region of unusually low GC content and may therefore be 'recently acquired'. Contains membrane-spanning hydrophobic regions.; integral membrane efflux protein complement(2047183..2048235) Neisseria meningitidis Z2491 907348 YP_002343350.1 CDS NMA2097 NC_003116.1 2048792 2049457 R NMA2097, pgm1, beta-phosphoglucomutase, len: 221aa; similar to many eg. SW:P71447 (PGMB_LACLA) pgmB,beta-phosphoglucomutase from Lactococcus lactis (subsp. lactis) (221 aa) fasta scores; E(): 0, 66.4% identity in 220 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. Highly similar to the neighbouring gene NMA2093 (fasta scores; E(): 0, 95.9% identity in 221 aa overlap) indicating a duplication event.; beta-phosphoglucomutase complement(2048792..2049457) Neisseria meningitidis Z2491 907346 YP_002343351.1 CDS mapA NC_003116.1 2049470 2051728 R NMA2098, mapA, maltose phosphorylase, len: 752aa; similar to TR:O87772 (EMBL:AJ224340) mapA, maltose phosphorylase from Lactobacillus sanfrancisco (753 aa) fasta scores; E(): 0, 59.9% identity in 749 aa overlap. C-terminus highly similar to the neighbouring gene NMA2094 (fasta scores; E(): 3.5e-32, 98.8% identity in 86 aa overlap) indicating a duplication event.; maltose phosphorylase complement(2049470..2051728) Neisseria meningitidis Z2491 907345 YP_002343352.1 CDS NMA2099 NC_003116.1 2051961 2052971 R NMA2099, galM, aldose 1-epimerase (mutarotase),len: 336aa; similar to many eg. SW:P21955 (GALM_STRTR) galM, aldose 1-epimerase (mutarotase) from Streptococcus thermophilus (348 aa) fasta scores; E(): 4e-22, 35.3% identity in 340 aa overlap. Contains Pfam match to entry PF01263 Aldose_epim, Aldose 1-epimerase.; aldose 1-epimerase complement(2051961..2052971) Neisseria meningitidis Z2491 907344 YP_002343353.1 CDS NMA2100 NC_003116.1 2052975 2054330 R NMA2100, integral membrane transport protein, len: 451aa; similar to many eg. SW:Q03411 (STP_SPIOL) sucrose transport protein from Spinacia oleracea (Spinach) (525 aa) fasta scores; E(): 6.5e-07,24.5% identity in 493 aa overlap.; integral membrane transport protein complement(2052975..2054330) Neisseria meningitidis Z2491 907343 YP_002343354.1 CDS NMA2101 NC_003116.1 2054717 2056393 D ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 2054717..2056393 Neisseria meningitidis Z2491 907342 YP_002343355.1 CDS NMA2102 NC_003116.1 2056453 2056938 R NMA2102, pgpA, phosphatidylglycerophosphatase A,inner membrane, len: 161aa; similar to SW:P18200 (PGPA_ECOLI) pgpA, phosphatidylglycerophosphatase A from Escherichia coli (172 aa) fasta scores; E(): 6.7e-24,42.1% identity in 145 aa overlap. Contains membrane-spanning hydrophobic regions.; phosphatidylglycerophosphatase A complement(2056453..2056938) Neisseria meningitidis Z2491 907341 YP_002343356.1 CDS thiL NC_003116.1 2056931 2057887 R catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase complement(2056931..2057887) Neisseria meningitidis Z2491 907340 YP_002343357.1 CDS NMA2105 NC_003116.1 2058708 2059436 R NMA2105, rmpM, outer membrane protein class 4, len: 242aa; strongly similar to SW:P38367 (OMP4_NEIME) rmpM,outer membrane protein class 4 from Neisseria meningitidis (240 aa) fasta scores; E(): 0, 99.2% identity in 242 aa overlap. Contains Pfam match to entry PF00691 OmpA, OmpA family and Prosite match to PS01068 OmpA-like domain.; outer membrane protein class 4 complement(2058708..2059436) Neisseria meningitidis Z2491 907339 YP_002343358.1 CDS NMA2106 NC_003116.1 2059800 2060750 D NMA2106, transcriptional regulator, len: 316aa; similar to many eg. SW:P06613 (CYSB_ECOLI) cysB, cys regulon transcriptional activator (324 aa) fasta scores; E(): 0, 50.6% identity in 316 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and Prosite match to PS00044 Bacterial regulatory proteins, lysR family signature.; transcriptional regulator CysB-like protein 2059800..2060750 Neisseria meningitidis Z2491 907338 YP_002343359.1 CDS NMA2107 NC_003116.1 2060863 2061597 R NMA2107, anaerobic transcriptional regulatory protein, len: 244aa; similar to many eg. SW:P23926 (ANR_PSEAE) transcriptional activator protein Anr from seudomonas aeruginosa (244 aa) fasta scores; E(): 0, 47.8% identity in 226 aa overlap. Contains Pfam match to entry PF00027 cNMP_binding, Cyclic nucleotide-binding domain and Pfam match to entry PF00325 crp, Bacterial regulatory proteins, crp family. Contains helix-turn-helix motif 190-211aa (+3.65 SD).; anaerobic transcriptional regulatory protein complement(2060863..2061597) Neisseria meningitidis Z2491 907337 YP_002343360.1 CDS hemN NC_003116.1 2061798 2063219 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 2061798..2063219 Neisseria meningitidis Z2491 907336 YP_002343361.1 CDS NMA2109 NC_003116.1 2063572 2065146 R NMA2109, phosphate permease, len: 524aa; similar to TR:Q50684 (EMBL:Z77163) phosphate permease from Mycobacterium tuberculosis (552 aa) fasta scores; E(): 0, 58.3% identity in 511 aa overlap. Contains Pfam match to entry PF01384 PHO4, Phosphate transporter family.; phosphate permease complement(2063572..2065146) Neisseria meningitidis Z2491 907335 YP_002343362.1 CDS anmK NC_003116.1 2065468 2066571 D catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 2065468..2066571 Neisseria meningitidis Z2491 907334 YP_002343363.1 CDS NMA2112 NC_003116.1 2066691 2067632 D NMA2112, mafA2, adhesin, len: 313aa; similar to TR:AAD31038 (EMBL:AF142582) MafA adhesin from Neisseria gonorrhoeae (320 aa) fasta scores; E(): 0, 62.4% identity in 314 aa overlap. Also similar to NMA0325 fasta scores; E(): 0, 62.4% identity in 314 aa overlap.; adhesin MafA2 2066691..2067632 Neisseria meningitidis Z2491 907333 YP_002343364.1 CDS NMA2113 NC_003116.1 2067636 2069132 D NMA2113, mafB2, adhesin, len: 498aa; similar to TR:AAD31039 (EMBL:AF142582) adhesin MafB from Neisseria gonorrhoeae (509 aa) fasta scores; E(): 0, 30.7% identity in 514 aa overlap. Also similar to NMA0853 fasta scores; E(): 0, 38.6% identity in 412 aa overlap and NMA0324 fasta scores; E(): 0, 31.6% identity in 503 aa overlap.; adhesin MafB2 2067636..2069132 Neisseria meningitidis Z2491 907332 YP_002343365.1 CDS NMA2114 NC_003116.1 2069147 2069377 D NMA2114, hypothetical protein, len: 2114aa; lies within a region of unusually low GC content.; hypothetical protein 2069147..2069377 Neisseria meningitidis Z2491 907331 YP_002343366.1 CDS NMA2115 NC_003116.1 2069526 2070200 D NMA2115, hypothetical protein, len: 224aa; lies within a region of unusually low GC content.; hypothetical protein 2069526..2070200 Neisseria meningitidis Z2491 907330 YP_002343367.1 CDS NMA2116 NC_003116.1 2070178 2070459 D NMA2116, hypothetical protein, len: 93aa; lies within a region of unusually low GC content.; hypothetical protein 2070178..2070459 Neisseria meningitidis Z2491 907329 YP_002343368.1 CDS NMA2117 NC_003116.1 2070639 2071124 D NMA2117, hypothetical protein, len: 161aa; lies within a region of unusually low GC content.; hypothetical protein 2070639..2071124 Neisseria meningitidis Z2491 907328 YP_002343369.1 CDS NMA2118 NC_003116.1 2071193 2071570 D NMA2118, hypothetical protein, len: 125aa; lies within a region of unusually low GC content.; hypothetical protein 2071193..2071570 Neisseria meningitidis Z2491 907327 YP_002343370.1 CDS NMA2120 NC_003116.1 2071875 2072276 D NMA2120, hypothetical protein, len: 133aa; lies within a region of unusually low GC content.; hypothetical protein 2071875..2072276 Neisseria meningitidis Z2491 907326 YP_002343371.1 CDS NMA2121 NC_003116.1 2072376 2072891 D NMA2121, hypothetical protein, len: 171aa; lies within a region of unusually low GC content.; hypothetical protein 2072376..2072891 Neisseria meningitidis Z2491 907325 YP_002343372.1 CDS NMA2122 NC_003116.1 2073056 2074180 D NMA2122, hypothetical protein, len: 374aa; hypothetical protein 2073056..2074180 Neisseria meningitidis Z2491 907324 YP_002343373.1 CDS NMA2123 NC_003116.1 2074267 2074542 R NMA2123, frpC', partial CDS, hypothetical protein, len: 91aa; highly similar to the N-terminus of SW:P55127 (FRPC_NEIME) iron-regulated protein FrpC from Neisseria meningitidis strain FAM20 (1829 aa) fasta scores; E(): 3.4e-29, 96.2% identity in 78 aa overlap.; hypothetical protein complement(2074267..2074542) Neisseria meningitidis Z2491 907323 YP_002343374.1 CDS NMA2124 NC_003116.1 2074559 2075326 R NMA2124, outer membrane hypothetical protein, len: 255aa; strongly similar to TR:Q08840 (EMBL:L06299) hypothetical protein from Neisseria meningitidis strain FAM20 (271 aa) fasta scores; E(): 0,90.0% identity in 271 aa overlap.; hypothetical protein complement(2074559..2075326) Neisseria meningitidis Z2491 907322 YP_002343375.1 CDS NMA2126 NC_003116.1 2075713 2075988 R NMA2126, hypothetical protein, len: 91aa; similar to TR:P95364 (EMBL:U82701) hypothetical protein from Neisseria gonorrhoeae (91 aa) fasta scores; E(): 0, 95.6% identity in 91 aa overlap.; hypothetical protein complement(2075713..2075988) Neisseria meningitidis Z2491 907321 YP_002343376.1 CDS NMA2127 NC_003116.1 2075985 2077268 R NMA2127, integral membrane signal transducer protein, len: 427aa; similar to many eg. TR:P95363 (EMBL:U82701) hypothetical protein from Neisseria gonorrhoeae (427 aa) fasta scores; E(): 0, 97.9% identity in 427 aa overlap and SW:P36670 (AMPG_ECOLI) AmpG, signal transducer protein from Escherichia coli (491 aa) fasta scores; E(): 0, 40.2% identity in 398 aa overlap. Contains membrane-spanning hydrophobic regions.; integral membrane signal transducer protein complement(2075985..2077268) Neisseria meningitidis Z2491 907320 YP_002343377.1 CDS NMA2128 NC_003116.1 2077423 2078841 R NMA2128, glnA, glutamine synthetase, len: 472aa; strongly similar to many eg. TR:P95395 (EMBL:U82856) glnA,glutamine synthetase from Neisseria meningitidis strain M470 (468 aa) fasta scores; E(): 0, 99.6% identity in 468 aa overlap. Contains Pfam match to entry PF00120 gln-synt,Glutamine synthetase; Prosite match to PS00182 Glutamine synthetase class-I adenylation site; Prosite match to PS00181 Glutamine synthetase ATP-binding region signature and Prosite match to PS00180 Glutamine synthetase signature 1.; glutamine synthetase complement(2077423..2078841) Neisseria meningitidis Z2491 907319 YP_002343378.1 CDS NMA2129 NC_003116.1 2079146 2079961 D NMA2129, aroE, shikimate dehydrogenase, len: 271aa; strongly similar to many eg. TR:P95387 (EMBL:U82840) aroE,shikimate dehydrogenase from Neisseria meningitidis strain 44/76 (269 aa) fasta scores; E(): 0, 98.9% identity in 269 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase.; shikimate dehydrogenase 2079146..2079961 Neisseria meningitidis Z2491 907318 YP_002343379.1 CDS mtgA NC_003116.1 2079964 2080665 D glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 2079964..2080665 Neisseria meningitidis Z2491 907317 YP_002343380.1 CDS NMA2131 NC_003116.1 2081256 2082020 R NMA2131, ABC transporter ATP-binding protein, len: 254aa; similar to many of undefined function eg. TR:O30650 (EMBL:AF013987) ABC transporter ATP-binding protein from Vibrio cholerae (241 aa) fasta scores; E(): 0, 61.5% identity in 239 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter; Prosite match to PS00211 ABC transporters family signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; ABC transporter ATP-binding protein complement(2081256..2082020) Neisseria meningitidis Z2491 907316 YP_002343381.1 CDS NMA2132 NC_003116.1 2082064 2082594 R NMA2132, outer membrane hypothetical protein, len: 176aa; similar to SW:P45074 (YHBN_HAEIN) hypothetical protein from Haemophilus influenzae fasta scores; E(): 4.3e-14, 39.5% identity in 172 aa overlap.; hypothetical protein complement(2082064..2082594) Neisseria meningitidis Z2491 907315 YP_002343382.1 CDS NMA2133 NC_003116.1 2082575 2083156 R NMA2133, periplasmic hypothetical protein,len: 193aa; hypothetical protein complement(2082575..2083156) Neisseria meningitidis Z2491 907314 YP_002343383.1 CDS NMA2134 NC_003116.1 2083153 2083689 R NMA2134, conserved hypothetical protein, len: 178aa; similar to many eg. SW:P45396 (YRBI_ECOLI) hypothetical protein from Escherichia coli (188 aa) fasta scores; E(): 1.5e-28, 46.0% identity in 174 aa overlap.; hypothetical protein complement(2083153..2083689) Neisseria meningitidis Z2491 907313 YP_002343384.1 CDS NMA2135 NC_003116.1 2083907 2084881 R NMA2135, conserved hypothetical protein, len: 324aa; similar to many eg. SW:P45395 (YRBH_ECOLI) hypothetical protein from Escherichia coli (328 aa) fasta scores; E(): 0, 56.2% identity in 313 aa overlap. Contains two Pfam matches to entry PF00571 CBS, CBS domain and Pfam match to entry PF01380 SIS, SIS domain.; hypothetical protein complement(2083907..2084881) Neisseria meningitidis Z2491 907312 YP_002343385.1 CDS tal NC_003116.1 2084978 2086033 D catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 2084978..2086033 Neisseria meningitidis Z2491 907311 YP_002343386.1 CDS NMA2137 NC_003116.1 2086186 2086476 D NMA2137, hypothetical protein, len: 96aa; lies within a region of unusually low GC content.; hypothetical protein 2086186..2086476 Neisseria meningitidis Z2491 907310 YP_002343387.1 CDS NMA2138 NC_003116.1 2086493 2087380 D this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 2086493..2087380 Neisseria meningitidis Z2491 907309 YP_002343388.1 CDS NMA2139 NC_003116.1 2087450 2088460 R NMA2139, conserved hypothetical protein, len: 336aa; similar to many eg. SW:P32695 (YJBN_ECOLI) hypothetical protein from Escherichia coli (330 aa) fasta scores; E(): 0, 54.4% identity in 318 aa overlap. Contains Pfam match to entry PF01207 UPF0034, Uncharacterized protein family UPF0034 and Prosite match to PS01136 Uncharacterized protein family UPF0034 signature.; tRNA-dihydrouridine synthase A complement(2087450..2088460) Neisseria meningitidis Z2491 907308 YP_002343389.1 CDS NMA2140 NC_003116.1 2088491 2088982 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(2088491..2088982) Neisseria meningitidis Z2491 907307 YP_002343390.1 CDS NMA2141 NC_003116.1 2089056 2089775 R NMA2141, hypothetical protein, len: 239aa; hypothetical protein complement(2089056..2089775) Neisseria meningitidis Z2491 907306 YP_002343391.1 CDS NMA2142 NC_003116.1 2089885 2090751 R NMA2142, periplasmic hypothetical protein,len: 288aa; similar to SW:P37566 (YACD_BACSU) hypothetical protein from Bacillus subtilis (297 aa) fasta scores; E(): 7.7e-08, 22.6% identity in 292 aa overlap. Contains a cleavable N-terminal signal sequence.; hypothetical protein complement(2089885..2090751) Neisseria meningitidis Z2491 907305 YP_002343392.1 CDS NMA2143 NC_003116.1 2090800 2091078 R NMA2143, conserved hypothetical protein, len: 92aa; similar to many eg. SW:P29943 (YCB1_PSEDE) hypothetical protein from Pseudomonas denitrificans (93 aa) fasta scores; E(): 4.2e-07, 37.8% identity in 90 aa overlap.; hypothetical protein complement(2090800..2091078) Neisseria meningitidis Z2491 907304 YP_002343393.1 CDS NMA2144 NC_003116.1 2091078 2091368 R unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein complement(2091078..2091368) Neisseria meningitidis Z2491 907303 YP_002343394.1 CDS NMA2145 NC_003116.1 2091371 2091901 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(2091371..2091901) Neisseria meningitidis Z2491 907302 YP_002343395.1 CDS NMA2146 NC_003116.1 2092107 2094749 D NMA2146, tspA, Neisseria-specific antigen protein,len: 880aa; identical to TR:O86394 (EMBL:AJ010113) tspA,Neisseria-specific antigen protein from Neisseria meningitidis strain B:15:P1.16. (880 aa).; hypothetical protein 2092107..2094749 Neisseria meningitidis Z2491 907301 YP_002343396.1 CDS NMA2147 NC_003116.1 2094922 2095338 R NMA2147, gloA, lactoylglutathione lyase, len: 138aa; identical to SW:O33393 (LGUL_NEIME) gloA,lactoylglutathione lyase from Neisseria meningitidis strain B:15:P1.16 (138 aa). Similar to SW:Q60003 (LGUL_SALTY) gloA, lactoylglutathione lyase from Salmonella typhimurium (135 aa) fasta scores; E(): 0,67.7% identity in 127 aa overlap. Contains Pfam match to entry PF00903 Glyoxalase, Glyoxalase and Prosite match to PS00934 Glyoxalase I signature 1.; lactoylglutathione lyase complement(2094922..2095338) Neisseria meningitidis Z2491 907300 YP_002343397.1 CDS NMA2148 NC_003116.1 2095362 2096531 R NMA2148, periplasmic hypothetical protein,len: 389aa; similar to SW:P45576 (YCIM_ECOLI) hypothetical protein from Escherichia coli (389 aa) fasta scores; E(): 1.5e-32, 29.2% identity in 387 aa overlap. Contains a cleavable N-terminal signal sequence.; tetratricopeptide repeat protein complement(2095362..2096531) Neisseria meningitidis Z2491 907299 YP_002343398.1 CDS NMA2149 NC_003116.1 2096542 2096856 R NMA2149, inner membrane hypothetical protein, len: 104aa; weakly similar to TR:O32045 (EMBL:Z99118) hypothetical protein from Bacillus subtilis (107 aa) fasta scores; E(): 0.18, 35.0% identity in 80 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein complement(2096542..2096856) Neisseria meningitidis Z2491 907298 YP_002343399.1 CDS ilvE NC_003116.1 2097166 2098164 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 2097166..2098164 Neisseria meningitidis Z2491 907296 YP_002343400.1 CDS fabI NC_003116.1 2098349 2099134 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase complement(2098349..2099134) Neisseria meningitidis Z2491 907295 YP_002343401.1 CDS dapD NC_003116.1 2099289 2100110 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(2099289..2100110) Neisseria meningitidis Z2491 907294 YP_002343402.1 CDS pgi NC_003116.1 2100277 2101920 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(2100277..2101920) Neisseria meningitidis Z2491 907293 YP_002343403.1 CDS NMA2155 NC_003116.1 2102277 2103509 D NMA2155, pilG, pilus-assembly protein, len: 410aa; strongly similar to many eg. TR:Q57076 (EMBL:U32588) pilG,pilus-assembly protein from Neisseria gonorrhoeae (410 aa) fasta scores; E(): 0, 99.3% identity in 410 aa overlap. Contains Pfam match to entry PF00482 GSPII_F, Bacterial type II secretion system protein F domain and Prosite match to PS00874 Bacterial type II secretion system protein F signature. Also contains membrane-spanning hydrophobic regions.; pilus-assembly protein 2102277..2103509 Neisseria meningitidis Z2491 907292 YP_002343404.1 CDS NMA2156 NC_003116.1 2103583 2104443 D NMA2156, pilD, type IV prepilin leader peptidase,len: 286aa; strongly similar to many eg. SW:P33566 (LEP3_NEIGO) pilD, type IV prepilin peptidase from Neisseria gonorrhoeae (286 aa) fasta scores; E(): 0, 96.1% identity in 285 aa overlap. Contains Pfam match to entry PF01478 Peptidase_C20, Type III leader peptidase family and membrane-spanning hydrophobic regions.; type IV prepilin leader peptidase 2103583..2104443 Neisseria meningitidis Z2491 907291 YP_002343405.1 CDS NMA2157 NC_003116.1 2104445 2105077 D NMA2157, conserved hypothetical protein, len: 210aa; similar to many eg. SW:P36679 (YACE_ECOLI) hypothetical protein from Escherichia coli (206 aa) fasta scores; E(): 2.1e-19, 37.9% identity in 195 aa overlap. Contains Pfam match to entry PF01121 UPF0038,Uncharacterized protein family UPF0038 and Prosite match to PS01294 Uncharacterized protein family UPF0038 signature.; hypothetical protein 2104445..2105077 Neisseria meningitidis Z2491 907290 YP_002343406.1 CDS NMA2158 NC_003116.1 2105070 2105279 D NMA2158, conserved hypothetical protein, len: 69aa; similar to others eg. TR:O69083 (EMBL:AF062531) hypothetical protein from Pseudomonas putida GB-1 (66 aa) fasta scores; E(): 1.4e-10, 50.8% identity in 61 aa overlap.; hypothetical protein 2105070..2105279 Neisseria meningitidis Z2491 907289 YP_002343407.1 CDS NMA2159 NC_003116.1 2105364 2107040 R NMA2159, pilF, type IV pilus assembly protein, len: 558aa; strongly similar to many eg. SW:P37094 (PILF_NEIGO) pilF, type IV pilus assembly protein from Neisseria gonorrhoeae (558 aa) fasta scores; E(): 0, 99.3% identity in 558 aa overlap. Contains Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein; Prosite match to PS00662 Bacterial type II secretion system protein E signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).; type IV pilus assembly protein complement(2105364..2107040) Neisseria meningitidis Z2491 907288 YP_002343408.1 CDS NMA2160 NC_003116.1 2107484 2107930 R NMA2160, conserved hypothetical protein, len: 148aa; similar to many eg. SW:P44110 (YEAL_HAEIN) hypothetical protein from Haemophilus influenzae (150 aa) fasta scores; E(): 0, 63.3% identity in 147 aa overlap.; hypothetical protein complement(2107484..2107930) Neisseria meningitidis Z2491 907287 YP_002343409.1 CDS NMA2161 NC_003116.1 2107935 2108909 R NMA2161, ispB, octaprenyl-diphosphate synthase,len: 324aa; similar to many eg. SW:P19641 (ISPB_ECOLI) ispB, octaprenyl-diphosphate synthase from Escherichia coli (323 aa) fasta scores; E(): 0, 53.4% identity in 320 aa overlap. Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases; Prosite match to PS00444 Polyprenyl synthetases signature 2 and Prosite match to PS00723 Polyprenyl synthetases signature 1.; octaprenyl-diphosphate synthase complement(2107935..2108909) Neisseria meningitidis Z2491 907286 YP_002343410.1 CDS rplU NC_003116.1 2109133 2109441 D NMA2162, rplU, 50S ribosomal protein L21, len: 102aa; strongly similar to many eg. SW:P02422 (RL21_ECOLI) rplU, 50S ribosomal protein L21 from Escherichia coli (103 aa) fasta scores; E(): 5.3e-21, 54.9% identity in 102 aa overlap. Contains Pfam match to entry PF00829 Ribosomal_L21p, Ribosomal prokaryotic L21 protein and Prosite match to PS01169 Ribosomal protein L21 signature.; 50S ribosomal protein L21 2109133..2109441 Neisseria meningitidis Z2491 907285 YP_002343411.1 CDS rpmA NC_003116.1 2109466 2109738 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 2109466..2109738 Neisseria meningitidis Z2491 907284 YP_002343412.1 CDS NMA2164 NC_003116.1 2110077 2111261 D NMA2164, monooxygenase, len: 394aa; similar to many eg. SW:P25535 (VISC_ECOLI) hypothetical monooxygenase from Escherichia coli (400 aa) fasta scores; E(): 2.2e-27; 28.3% identity in 392 aa overlap and SW:P52019 (ERG1_MOUSE) squalene monooxygenase from Mus musculus (Mouse) (572 aa) fasta scores; E(): 0, 23.4% identity in 381 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase, Monooxygenase.; hypothetical protein 2110077..2111261 Neisseria meningitidis Z2491 907283 YP_002343413.1 CDS rpmG NC_003116.1 2111532 2111687 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(2111532..2111687) Neisseria meningitidis Z2491 907282 YP_002343414.1 CDS rpmB NC_003116.1 2111719 2111952 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(2111719..2111952) Neisseria meningitidis Z2491 907281 YP_002343415.1 CDS NMA2168 NC_003116.1 2112202 2113752 R NMA2168, emrB, multidrug resistance translocase,len: 516aa; strongly similar to many eg. SW:P27304 (EMRB_ECOLI) emrB, multidrug resistance translocase (512 aa) fasta scores; E(): 0, 57.5% identity in 504 aa overlap. Contains membrane-spanning hydrophobic regions.; multidrug resistance translocase complement(2112202..2113752) Neisseria meningitidis Z2491 907279 YP_002343416.1 CDS NMA2169 NC_003116.1 2113752 2114936 R NMA2169, emrA, multidrug resistance translocase,len: 394aa; similar to many eg. SW:P27303 (EMRA_ECOLI) emrA, multidrug resistance translocase from Escherichia coli (390 aa) fasta scores; E(): 0, 44.8% identity in 386 aa overlap. Contains Pfam match to entry PF00529 HlyD,HlyD family secretion protein; multidrug resistance translocase complement(2113752..2114936) Neisseria meningitidis Z2491 907278 YP_002343417.1 CDS NMA2170 NC_003116.1 2115348 2115821 D NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2115348..2115821 Neisseria meningitidis Z2491 907277 YP_002343418.1 CDS NMA2171 NC_003116.1 2115898 2116584 D NMA2171, conserved hypothetical inner membrane protein, len: 228aa; similar to many eg. SW:P37619 (YHHQ_ECOLI) hypothetical protein from Escherichia coli (221 aa) fasta scores; E(): 0, 66.5% identity in 209 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein 2115898..2116584 Neisseria meningitidis Z2491 907276 YP_002343419.1 CDS NMA2172 NC_003116.1 2117120 2118412 R NMA2172, conserved hypothetical protein, peptidase, len: 430aa; similar to many eg. SW:P44693 (YEBA_HAEIN) hypothetical protein from Haemophilus influenzae (475 aa) fasta scores; E(): 4.6e-23, 31.0% identity in 387 aa overlap. Contains Pfam match to entry PF01551 Peptidase_M37.; hypothetical protein complement(2117120..2118412) Neisseria meningitidis Z2491 907275 YP_002343420.1 CDS NMA2173 NC_003116.1 2118490 2119458 D NMA2173, hypothetical protein, len: 322aa; hypothetical protein 2118490..2119458 Neisseria meningitidis Z2491 907274 YP_002343421.1 CDS NMA2174 NC_003116.1 2119659 2121131 R NMA2174, conserved hypothetical protein, len: 490aa; similar to many eg. TR:Q9ZF57 (EMBL:AF118122) outer membrane protein from Neisseria meningitidis strain 8013#6 (488 aa) fasta scores; E(): 0,99.2% identity in 488 aa overlap and TR:O85049 (EMBL:AF039312) hypothetical protein from Moraxella catarrhalis (512 aa) fasta scores; E(): 0, 41.5% identity in 458 aa overlap.; hypothetical protein complement(2119659..2121131) Neisseria meningitidis Z2491 907273 YP_002343422.1 CDS NMA2175 NC_003116.1 2121367 2123226 R NMA2175, vapA, virulence associated protein, len: 619aa; strongly similar to TR:Q9ZF58 (EMBL:AF118122) vapA, virulence associated protein from Neisseria meningitidis strain 8013#6 (619 aa) fasta scores; E(): 0, 98.4% identity in 619 aa overlap.; virulence associated protein complement(2121367..2123226) Neisseria meningitidis Z2491 907272 YP_002343423.1 CDS NMA2176 NC_003116.1 2124655 2124900 R NMA2176, hypothetical protein, len: 81aa; hypothetical protein complement(2124655..2124900) Neisseria meningitidis Z2491 907271 YP_002343424.1 CDS NMA2177 NC_003116.1 2125003 2125440 D NMA2177, conserved hypothetical inner membrane protein, len: 145aa; similar to many eg. TR:Q9ZJD5 (EMBL:AE001560) hypothetical protein from Helicobacter pylori J99 (148 aa) fasta scores; E(): 3.9e-15, 40.7% identity in 145 aa overlap. Contains membrane-spanning hydrophobic regions.; conserved hypothetical inner membrane protein 2125003..2125440 Neisseria meningitidis Z2491 907270 YP_002343425.1 CDS NMA2178 NC_003116.1 2125452 2125928 D NMA2178, conserved hypothetical protein, len: 158aa; similar to TR:Q55960 (EMBL:D64005) hypothetical protein from Synechocystis sp. (strain PCC 6803) (154 aa) fasta scores; E(): 5.8e-28, 44.5% identity in 155 aa overlap.; hypothetical protein 2125452..2125928 Neisseria meningitidis Z2491 907269 YP_002343426.1 CDS NMA2179 NC_003116.1 2126278 2126766 R NMA2179, folA, dihydrofolate reductase, len: 162aa; similar to many eg. SW:P12833 (DYR3_SALTY) dhfrIII,dihydrofolate reductase type III from Salmonella typhimurium (162 aa) fasta scores; E(): 2.1e-26, 50.7% identity in 152 aa overlap. Contains Pfam match to entry PF00186 DiHfolate_red, Dihydrofolate reductase and Prosite match to PS00075 Dihydrofolate reductase signature.; dihydrofolate reductase complement(2126278..2126766) Neisseria meningitidis Z2491 907268 YP_002343427.1 CDS aroG NC_003116.1 2126834 2127889 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(2126834..2127889) Neisseria meningitidis Z2491 907267 YP_002343428.1 CDS NMA2181 NC_003116.1 2127943 2128308 D NMA2181, hypothetical protein (improbable CDS),len: 121aa; hypothetical protein 2127943..2128308 Neisseria meningitidis Z2491 907266 YP_002343429.1 CDS NMA2182 NC_003116.1 2128354 2128446 D NMA2182, hypothetical protein (improbable CDS),len: 30aa; hypothetical protein 2128354..2128446 Neisseria meningitidis Z2491 907265 YP_002343430.1 CDS NMA2185 NC_003116.1 2129169 2129822 R NMA2185, insertion element IS1016C2 transposase, len: 217aa; similar to many eg. TR:Q48234 (EMBL:X59756) insertion sequence IS1016-V6 from Haemophilus influenzae (191 aa) fasta scores; E(): 0,70.3% identity in 175 aa overlap. Also highly similar to many others from Neisseria meningitidis eg. NMA0471,NMA0769.; insertion element IS1016C2 transposase complement(2129169..2129822) Neisseria meningitidis Z2491 907262 YP_002343431.1 CDS NMA2186 NC_003116.1 2129942 2130400 R NMA2186, hypothetical protein, len: 152aa; similar to TR:CAB44963 (EMBL:AJ242838) hypothetical protein from Neisseria meningitidis serogroup C strain FAM18 (148 aa) fasta scores; E(): 0, 97.2% identity in 145 aa overlap; hypothetical protein complement(2129942..2130400) Neisseria meningitidis Z2491 907261 YP_002343432.1 CDS NMA2187 NC_003116.1 2130512 2130976 R NMA2187, DNA transport competence protein,len: 154 aa; region of similarity to SW:P39694 (CME1_BACSU) ComE a late competence operon protein from Bacillus subtilis (205 aa) fasta scores; E(): 9.8e-07,47.6% identity in 63 aa overlap. Previously sequenced therefore identical to TR:CAB44958 (EMBL:AJ242837) ComEA protein (fragment) from Neisseria meningitidis serogroup A strain Z2491 (170 aa) fasta scores; E(): 0, 100.0% identity in 154 aa overlap. Contains Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif and membrane-spanning hydrophobic region. Identical to NMA1915, and almost identical to NMA0211 (98.7% identity in 154 aa overlap), and NMA0423 (98.7% identity in 154 aa overlap); DNA transport competence protein complement(2130512..2130976) Neisseria meningitidis Z2491 907260 YP_002343433.1 CDS NMA2189 NC_003116.1 2136776 2137582 R NMA2189, hypothetical inner membrane protein, len: 268aa; weakly similar to many eg. TR:P76599 (EMBL:AE000347) hypothetical protein from Escherichia coli (288 aa) fasta scores; E(): 8.2e-13, 27.3% identity in 249 aa overlap. Contains membrane-spanning hydrophobic regions.; hypothetical protein complement(2136776..2137582) Neisseria meningitidis Z2491 907258 YP_002343434.1 CDS NMA2190 NC_003116.1 2137803 2139173 D NMA2190, ffh, signal recognition particle protein,len: 456aa; strongly similar to many eg. SW:P07019 (SR54_ECOLI) ffh, signal recognition particle protein from Escherichia coli (453 aa) fasta scores; E(): 0, 67.3% identity in 455 aa overlap. Contains Pfam match to entry PF00448 SRP54, SRP54-type protein; Prosite match to PS00300 SRP54-type proteins GTP-binding domain signature and potential coiled-coil region close to the N-terminus.; signal recognition particle protein 2137803..2139173 Neisseria meningitidis Z2491 907257 YP_002343435.1 CDS NMA2191 NC_003116.1 2139504 2140199 R NMA2191, thiol:disulphide interchange protein, len: 231aa; weakly similar to many eg. SW:P2499 (DSBA_ECOLI) DsbA, thiol:disulphide interchange protein from Escherichia coli (208 aa) fasta scores; E(): 5.3e-10,30.8% identity in 198 aa overlap. Also similar to NMA2209 (fasta scores; E(): 0, 73.5% identity in 230 aa overlap). Contains Pfam match to entry PF01323 DSBA, DSBA oxidoreductase and Prosite match to PS00194 Thioredoxin family active site. Contains a cleavable N-terminal signal sequence.; thiol:disulfide interchange protein complement(2139504..2140199) Neisseria meningitidis Z2491 907256 YP_002343436.1 CDS NMA2192 NC_003116.1 2140370 2141029 R NMA2192, conserved hypothetical protein, len: 219aa; similar to TR:O25892 (EMBL:AE000635) hypothetical protein from Helicobacter pylori (Campylobacter pylori) (224 aa) fasta scores; E(): 0, 47.5% identity in 223 aa overlap. Lies in a region of unusually low GC content.; hypothetical protein complement(2140370..2141029) Neisseria meningitidis Z2491 907255 YP_002343437.1 CDS NMA2193 NC_003116.1 2141227 2143338 R NMA2193, TonB-dependent receptor protein,len: 703aa; similar to many eg. SW:P48632 (FPVA_PSEAE) ferripyoverdine receptor from Pseudomonas aeruginosa (813 aa) fasta scores; E(): 2.4e-18, 24.1% identity in 602 aa overlap. Contains Pfam match to entry PF00593 TonB_boxC,TonB dependent receptor C-terminal region.; TonB-dependent receptor protein complement(2141227..2143338) Neisseria meningitidis Z2491 907254 YP_002343438.1 CDS NMA2195 NC_003116.1 2143524 2144129 R NMA2195, hypothetical protein, len: 201aa; similar to SW:P37261 (YC08_YEAST) hypothetical protein from Saccharomyces cerevisiae (Baker's yeast) (192 aa) fasta scores; E(): 3.2e-12, 32.1% identity in 184 aa overlap.; hypothetical protein complement(2143524..2144129) Neisseria meningitidis Z2491 907253 YP_002343439.1 CDS NMA2196 NC_003116.1 2144178 2144576 R NMA2196, conserved hypothetical inner membrane protein, len: 132aa; similar to many eg. SW:P44069 (Y886_HAEIN) hypothetical protein from Haemophilus influenzae (134 aa) fasta scores; E(): 5.1e-24, 55.0% identity in 129 aa overlap. Contains membrane-spanning hydrophobic regions.; conserved hypothetical inner membrane protein complement(2144178..2144576) Neisseria meningitidis Z2491 907252 YP_002343440.1 CDS NMA2197 NC_003116.1 2144684 2145595 D NMA2197, probable LysR-family transcriptional regulator, len: 303aa; similar to many eg. TR:AAD33772 (EMBL:AF139107) hypothetical transcriptional activator from Pseudomonas aeruginosa (306 aa) fasta scores; E(): 6.1e-29, 33.4% identity in 290 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and Prosite match to PS00044 Bacterial regulatory proteins, lysR family signature.; LysR-family transcriptional regulator 2144684..2145595 Neisseria meningitidis Z2491 907251 YP_002343441.1 CDS NMA2198 NC_003116.1 2145585 2146886 D NMA2198, phr, deoxyribodopyrimidine photolyase,len: 433aa; similar to many eg. SW:P00914 (PHR_ECOLI) phr,deoxyribodopyrimidine photolyase from Escherichia coli (472 aa) fasta scores; E(): 8.2e-15, 30.4% identity in 457 aa overlap. Contains Pfam match to entry PF00875 DNA_photolyase, DNA photolyase and Prosite match to PS00394 DNA photolyases class 1 signature 1.; deoxyribodopyrimidine photolyase 2145585..2146886 Neisseria meningitidis Z2491 907250 YP_002343442.1 CDS NMA2199 NC_003116.1 2146979 2147207 R NMA2199, hypothetical inner membrane protein, len: 76aa; contains membrane-spanning hydrophobic regions.; hypothetical protein complement(join(2146979..2147200,2147199..2147207)) Neisseria meningitidis Z2491 7163869 YP_002343443.1 CDS dinG NC_003116.1 2147279 2149429 D helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 2147279..2149429 Neisseria meningitidis Z2491 907248 YP_002343444.1 CDS NMA2201 NC_003116.1 2149465 2150079 D NMA2201, hypothetical protein, len: 204aa; similar to SW:P33218 (YEBE_ECOLI) hypothetical protein from Escherichia coli (219 aa) fasta scores; E(): 3.1e-07,29.2% identity in 212 aa overlap.; hypothetical protein 2149465..2150079 Neisseria meningitidis Z2491 907247 YP_002343445.1 CDS NMA2202 NC_003116.1 2150174 2152042 R NMA2202, inner membrane trans-acylase, len: 622aa; similar to TR:P74874 (EMBL:U65941) OafA integral membrane trans-acylase from Salmonella typhimurium (609 aa) fasta scores; E(): 4.9e-23, 31.4% identity in 488 aa overlap. Regions of similarity to others eg. 40-280aa similar to SW:P43993 (Y392_HAEIN) hypothetical protein from Haemophilus influenzae (245 aa) fasta scores; E(): 0, 60.7% identity in 239 aa overlap. Contains membrane-spanning hydrophobic regions.; inner membrane trans-acylase complement(2150174..2152042) Neisseria meningitidis Z2491 907246 YP_002343446.1 CDS purB NC_003116.1 2152123 2153493 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(2152123..2153493) Neisseria meningitidis Z2491 907245 YP_002343447.1 CDS NMA2204 NC_003116.1 2153565 2154197 R NMA2204, hypothetical protein, len: 210aa; similar to TR:Q46063 (EMBL:X81379) hypothetical protein from Corynebacterium glutamicum (211 aa) fasta scores; E(): 5.7e-30, 52.5% identity in 160 aa overlap.; hypothetical protein complement(2153565..2154197) Neisseria meningitidis Z2491 907244 YP_002343448.1 CDS NMA2205 NC_003116.1 2154506 2156386 D NMA2205, hypothetical protein, len: 635aa; hypothetical protein 2154506..2156386 Neisseria meningitidis Z2491 907243 YP_002343449.1 CDS NMA2206 NC_003116.1 2157620 2158663 R NMA2206, rotamase, len: 347aa; weakly similar to many eg. SW:P21202 (SURA_ECOLI) SurA, survival protein from Escherichia coli (428 aa) fasta scores; E(): 4.7e-09, 26.1% identity in 303 aa overlap. Contains Pfam match to entry PF00639 Rotamase, PPIC-type PPIASE domain and PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature; rotamase complement(2157620..2158663) Neisseria meningitidis Z2491 907242 YP_002343450.1 CDS NMA2207 NC_003116.1 2158786 2161194 R NMA2207, solvent tolerance protein, len: 802aa; similar to SW:P31554 (OSTA_ECOLI) solvent tolerance protein from Escherichia coli (784 aa) fasta scores; E(): 1.4e-30, 27.9% identity in 768 aa overlap.; solvent tolerance protein complement(2158786..2161194) Neisseria meningitidis Z2491 907241 YP_002343451.1 CDS NMA2208 NC_003116.1 2161264 2162268 D NMA2208, hypothetical protein, len: 334aa; similar to TR:AAD22455 (EMBL:AF116284) hypothetical protein from Pseudomonas aeruginosa (338 aa) fasta scores; E(): 0,44.0% identity in 332 aa overlap.; hypothetical protein 2161264..2162268 Neisseria meningitidis Z2491 907240 YP_002343452.1 CDS NMA2209 NC_003116.1 2162325 2163023 R NMA2209, thiol:disulphide interchange protein, len: 232aa; weakly similar to many eg. SW:P52234 (DSBA_ERWCH) DsbA, thiol:disulphide interchange protein from Erwinia chrysanthemi (207 aa) fasta scores; E(): 7e-06, 26.4% identity in 193 aa overlap. Also similar to NMA2191 (fasta scores; E(): 0, 73.5% identity in 230 aa overlap). Contains Pfam match to entry PF01323 DSBA, DSBA oxidoreductase and Prosite match to PS00194 Thioredoxin family active site. Contains a cleavable N-terminal signal sequence.; thiol:disulfide interchange protein complement(2162325..2163023) Neisseria meningitidis Z2491 907239 YP_002343453.1 CDS NMA2210 NC_003116.1 2163482 2165020 D NMA2210, inner membrane virulence factor protein, len: 512aa; similar to many MviN virulence factor homologs eg. SW:P37169 (MVIN_SALTY) from Salmonella typhimurium (524 aa) fasta scores; E(): 0, 63.5% identity in 509 aa overlap. Contains membrane-spanning hydrophobic regions.; inner membrane virulence factor protein 2163482..2165020 Neisseria meningitidis Z2491 907238 YP_002343454.1 CDS NMA2211 NC_003116.1 2165153 2166109 D NMA2211, conserved hypothetical protein, len: 318aa; similar to many eg. SW:P45524 (YHET_ECOLI) hypothetical protein from Escherichia coli (340 aa) fasta scores; E(): 0, 36.6% identity in 314 aa overlap. Contains PS01133 Uncharacterized protein family UPF0017 signature.; hypothetical protein 2165153..2166109 Neisseria meningitidis Z2491 907237 YP_002343455.1 CDS trpC NC_003116.1 2166160 2166942 D involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 2166160..2166942 Neisseria meningitidis Z2491 907236 YP_002343456.1 CDS NMA2213 NC_003116.1 2167007 2169307 D NMA2213, recQ, ATP-dependent DNA helicase, len: 801aa; similar to many eg. SW:P15043 (RECQ_ECOLI) recQ,ATP-dependent DNA helicase from Escherichia coli (607 aa) fasta scores; E(): 0, 47.1% identity in 594 aa overlap. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase; Pfam match to entry PF00271 helicase_C,Helicases conserved C-terminal domain and two Pfam matches to entry PF00570 HRDC, HRDC domain.; ATP-dependent DNA helicase 2167007..2169307 Neisseria meningitidis Z2491 907235 YP_002343457.1 CDS NMA2214 NC_003116.1 2169450 2170076 R NMA2214, hypothetical protein, len: 208aa; hypothetical protein complement(2169450..2170076) Neisseria meningitidis Z2491 907234 YP_002343458.1 CDS NMA2215 NC_003116.1 2170152 2170940 R NMA2215, hypothetical protein, len: 262aa; hypothetical protein complement(2170152..2170940) Neisseria meningitidis Z2491 907233 YP_002343459.1 CDS NMA2216 NC_003116.1 2170774 2171712 R NMA2216, hydrolase, len: 312aa; similar to TR:O67982 (EMBL:AF003947) 3-oxoadipate enol-lactone-hydrolase/4-carboxymuconolactone-decarboxyla se from Rhodococcus opacus (400 aa) fasta scores; E(): 3.9e-10, 28.7% identity in 265 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.; hydrolase complement(2170774..2171712) Neisseria meningitidis Z2491 907232 YP_002343460.1 CDS NMA2217 NC_003116.1 2171684 2172409 D NMA2217, hypothetical protein, len: 246aa; similar to others of undefined function eg. SW:P31773 (COMF_HAEIN) competence protein from Haemophilus influenzae (229 aa) fasta scores; E(): 1.4e-17, 32.5% identity in 231 aa overlap.; hypothetical protein 2171684..2172409 Neisseria meningitidis Z2491 907231 YP_002343461.1 CDS NMA2218 NC_003116.1 2172474 2172938 D NMA2218, tRNA/rRNA methyltransferase, len: 154aa; similar to many eg. SW:P33899 (YIBK_ECOLI) hypothetical tRNA/rRNA methyltransferase from Escherichia coli (157 aa) fasta scores; E(): 0, 62.3% identity in 154 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family.; tRNA/rRNA methyltransferase 2172474..2172938 Neisseria meningitidis Z2491 907230 YP_002343462.1 CDS NMA2219 NC_003116.1 2173066 2173785 D NMA2219, periplasmic protein, len: 239aa; weakly similar to many of undefined function eg. TRNEW:AAD32233 (EMBL:AF147448) from Pseudomonas aeruginosa (342 aa) fasta scores; E(): 4.2e-24, 40.5% identity in 232 aa overlap.; hypothetical protein 2173066..2173785 Neisseria meningitidis Z2491 907229 YP_002343463.1 CDS NMA2220 NC_003116.1 2173785 2174165 D NMA2220, hypothetical protein, len: 126aa; hypothetical protein 2173785..2174165 Neisseria meningitidis Z2491 907228 YP_002343464.1 CDS ruvA NC_003116.1 2174247 2174831 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2174247..2174831 Neisseria meningitidis Z2491 907227 YP_002343465.1 CDS NMA2223 NC_003116.1 2174994 2176850 D NMA2223, probable ABC transporter, len: 618aa; similar to many eg. SW:Q57180 (YA51_HAEIN) hypothetical ABC transporter from Haemophilus influenzae (614 aa) fasta scores; E(): 0, 76.5% identity in 614 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter; Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00211 ABC transporters family signature; ABC transporter 2174994..2176850 Neisseria meningitidis Z2491 907225 YP_002343466.1 CDS NMA2224 NC_003116.1 2176855 2177778 D EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 2176855..2177778 Neisseria meningitidis Z2491 907224 YP_002343467.1 CDS NMA2225 NC_003116.1 2178042 2178266 D catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 2178042..2178266 Neisseria meningitidis Z2491 907223 YP_002343468.1 CDS NMA2226 NC_003116.1 2178250 2179146 D NMA2226, ispA, geranyltranstransferase, len: 298aa; similar to many eg. SW:P22939 (ISPA_ECOLI) ispA,geranyltranstransferase from Escherichia coli (299 aa) fasta scores; E(): 0, 49.1% identity in 289 aa overlap. Contains Pfam match to entry PF00348 polyprenyl_synt,Polyprenyl synthetases; Prosite match to PS00723 Polyprenyl synthetases signature 1 and Prosite match to PS00444 Polyprenyl synthetases signature 2.; geranyltranstransferase 2178250..2179146 Neisseria meningitidis Z2491 907222 YP_002343469.1 CDS NMA2227 NC_003116.1 2179255 2179605 R NMA2227, hypothetical inner membrane protein, len: 116aa; Contains membrane-spanning hydrophobic regions.; hypothetical protein complement(2179255..2179605) Neisseria meningitidis Z2491 907221 YP_002343470.1 CDS nuoN NC_003116.1 2179666 2181111 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(2179666..2181111) Neisseria meningitidis Z2491 907220 YP_002343471.1 CDS nuoM NC_003116.1 2181121 2182617 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(2181121..2182617) Neisseria meningitidis Z2491 907219 YP_002343472.1 CDS NMA2230 NC_003116.1 2182654 2184369 R NMA2230, hypothetical protein, len: 571aa; weakly similar to many eg. TR:O34810 (EMBL:AE000641) hypothetical protein from Helicobacter pylori (Campylobacter pylori) (578 aa) fasta scores; E(): 3e-21, 23.2% identity in 604 aa overlap. Lies in a region of unusually low GC content.; hypothetical protein complement(2182654..2184369) Neisseria meningitidis Z2491 907218 NMAt01 tRNA NMAt01 NC_003116.1 54209 54285 R tRNA-Asp complement(54209..54285) Neisseria meningitidis Z2491 3233632 NMAt02 tRNA NMAt02 NC_003116.1 54318 54393 R tRNA-Val complement(54318..54393) Neisseria meningitidis Z2491 3233633 NMAt03 tRNA NMAt03 NC_003116.1 54433 54509 R tRNA-Asp complement(54433..54509) Neisseria meningitidis Z2491 3233594 NMAt04 tRNA NMAt04 NC_003116.1 54542 54617 R tRNA-Val complement(54542..54617) Neisseria meningitidis Z2491 3233595 NMAt05 tRNA NMAt05 NC_003116.1 77692 77767 D tRNA-Thr 77692..77767 Neisseria meningitidis Z2491 3233596 NMAt06 tRNA NMAt06 NC_003116.1 134789 134864 R tRNA-Trp complement(134789..134864) Neisseria meningitidis Z2491 3233597 NMAt07 tRNA NMAt07 NC_003116.1 136104 136178 R tRNA-Thr complement(136104..136178) Neisseria meningitidis Z2491 3233598 NMAt08 tRNA NMAt08 NC_003116.1 136188 136261 R tRNA-Gly complement(136188..136261) Neisseria meningitidis Z2491 3233599 NMAt09 tRNA NMAt09 NC_003116.1 136292 136375 R tRNA-Tyr complement(136292..136375) Neisseria meningitidis Z2491 3233600 NMAt10 tRNA NMAt10 NC_003116.1 198082 198157 R tRNA-Ala complement(198082..198157) Neisseria meningitidis Z2491 3233603 NMAt11 tRNA NMAt11 NC_003116.1 198164 198240 R tRNA-Ile complement(198164..198240) Neisseria meningitidis Z2491 3233604 NMAt12 tRNA NMAt12 NC_003116.1 243017 243092 R tRNA-Lys complement(243017..243092) Neisseria meningitidis Z2491 3233606 NMAt13 tRNA NMAt13 NC_003116.1 329791 329868 D tRNA-Pro 329791..329868 Neisseria meningitidis Z2491 3233607 NMAt14 tRNA NMAt14 NC_003116.1 329893 329969 D tRNA-Arg 329893..329969 Neisseria meningitidis Z2491 3233608 NMAt15 tRNA NMAt15 NC_003116.1 329997 330072 D tRNA-His 329997..330072 Neisseria meningitidis Z2491 3233609 NMAt16 tRNA NMAt16 NC_003116.1 365357 365433 R tRNA-Met complement(365357..365433) Neisseria meningitidis Z2491 3233610 NMAt17 tRNA NMAt17 NC_003116.1 392992 393068 D tRNA-Ile 392992..393068 Neisseria meningitidis Z2491 3233612 NMAt18 tRNA NMAt18 NC_003116.1 393075 393150 D tRNA-Ala 393075..393150 Neisseria meningitidis Z2491 3233613 NMAt19 tRNA NMAt19 NC_003116.1 541637 541722 R tRNA-Leu complement(541637..541722) Neisseria meningitidis Z2491 3233616 NMAt20 tRNA NMAt20 NC_003116.1 589249 589324 D tRNA-Lys 589249..589324 Neisseria meningitidis Z2491 3233617 NMAt21 tRNA NMAt21 NC_003116.1 695900 695976 R tRNA-Pro complement(695900..695976) Neisseria meningitidis Z2491 3233618 NMAt22 tRNA NMAt22 NC_003116.1 831871 831947 D tRNA-Pro 831871..831947 Neisseria meningitidis Z2491 3233619 NMAt23 tRNA NMAt23 NC_003116.1 853436 853528 D tRNA-Ser 853436..853528 Neisseria meningitidis Z2491 3233620 NMAt24 tRNA NMAt24 NC_003116.1 900080 900156 D tRNA-Val 900080..900156 Neisseria meningitidis Z2491 3233621 NMAt25 tRNA NMAt25 NC_003116.1 920559 920635 D tRNA-Arg 920559..920635 Neisseria meningitidis Z2491 3233622 NMAt26 tRNA NMAt26 NC_003116.1 920653 920727 D tRNA-Glu 920653..920727 Neisseria meningitidis Z2491 3233623 NMAt27 tRNA NMAt27 NC_003116.1 1035835 1035910 D tRNA-Thr 1035835..1035910 Neisseria meningitidis Z2491 3233624 NMAt28 tRNA NMAt28 NC_003116.1 1041389 1041464 D tRNA-Gln 1041389..1041464 Neisseria meningitidis Z2491 3233625 NMAt29 tRNA NMAt29 NC_003116.1 1041477 1041552 D tRNA-Gln 1041477..1041552 Neisseria meningitidis Z2491 3233626 NMAt30 tRNA NMAt30 NC_003116.1 1041561 1041636 D tRNA-Gln 1041561..1041636 Neisseria meningitidis Z2491 3233627 NMAt31 tRNA NMAt31 NC_003116.1 1062901 1062991 D tRNA-Ser 1062901..1062991 Neisseria meningitidis Z2491 3233628 NMAt32 tRNA NMAt32 NC_003116.1 1063204 1063293 D tRNA-Ser 1063204..1063293 Neisseria meningitidis Z2491 3233629 NMAt33 tRNA NMAt33 NC_003116.1 1272037 1272127 R tRNA-Ser complement(1272037..1272127) Neisseria meningitidis Z2491 3233631 NMAt34 tRNA NMAt34 NC_003116.1 1272166 1272252 R tRNA-Leu complement(1272166..1272252) Neisseria meningitidis Z2491 3233563 NMAt35 tRNA NMAt35 NC_003116.1 1272288 1272374 R tRNA-Leu complement(1272288..1272374) Neisseria meningitidis Z2491 3233564 NMAt36 tRNA NMAt36 NC_003116.1 1320439 1320523 R tRNA-Leu complement(1320439..1320523) Neisseria meningitidis Z2491 3233565 NMAt37 tRNA NMAt37 NC_003116.1 1585495 1585571 D tRNA-Arg 1585495..1585571 Neisseria meningitidis Z2491 3233566 NMAt38 tRNA NMAt38 NC_003116.1 1585589 1585663 D tRNA-Glu 1585589..1585663 Neisseria meningitidis Z2491 3233567 NMAt39 tRNA NMAt39 NC_003116.1 1660380 1660455 R tRNA-Asn complement(1660380..1660455) Neisseria meningitidis Z2491 3233568 NMAt40 tRNA NMAt40 NC_003116.1 1712481 1712565 R tRNA-Leu complement(1712481..1712565) Neisseria meningitidis Z2491 3233569 NMAt41 tRNA NMAt41 NC_003116.1 1723553 1723642 R tRNA-Leu complement(1723553..1723642) Neisseria meningitidis Z2491 3233570 NMAt42 tRNA NMAt42 NC_003116.1 1723745 1723818 R tRNA-Cys complement(1723745..1723818) Neisseria meningitidis Z2491 3233571 NMAt43 tRNA NMAt43 NC_003116.1 1723844 1723919 R tRNA-Gly complement(1723844..1723919) Neisseria meningitidis Z2491 3233572 NMAt44 tRNA NMAt44 NC_003116.1 1723941 1724016 R tRNA-Gly complement(1723941..1724016) Neisseria meningitidis Z2491 3233573 NMAt45 tRNA NMAt45 NC_003116.1 1724040 1724115 R tRNA-Gly complement(1724040..1724115) Neisseria meningitidis Z2491 3233574 NMAt46 tRNA NMAt46 NC_003116.1 1724141 1724216 R tRNA-Gly complement(1724141..1724216) Neisseria meningitidis Z2491 3233575 NMAt47 tRNA NMAt47 NC_003116.1 1761107 1761182 D tRNA-Glu 1761107..1761182 Neisseria meningitidis Z2491 3233576 NMAt48 tRNA NMAt48 NC_003116.1 1845093 1845168 R tRNA-Ala complement(1845093..1845168) Neisseria meningitidis Z2491 3233579 NMAt49 tRNA NMAt49 NC_003116.1 1845175 1845251 R tRNA-Ile complement(1845175..1845251) Neisseria meningitidis Z2491 3233580 NMAt50 tRNA NMAt50 NC_003116.1 1869304 1869379 D tRNA-Arg 1869304..1869379 Neisseria meningitidis Z2491 3233582 NMAt51 tRNA NMAt51 NC_003116.1 1893013 1893088 D tRNA-Met 1893013..1893088 Neisseria meningitidis Z2491 3233583 NMAt52 tRNA NMAt52 NC_003116.1 1941041 1941116 R tRNA-Asn complement(1941041..1941116) Neisseria meningitidis Z2491 3233584 NMAt53 tRNA NMAt53 NC_003116.1 2025756 2025832 D tRNA-Met 2025756..2025832 Neisseria meningitidis Z2491 3233585 NMAt54 tRNA NMAt54 NC_003116.1 2025840 2025915 D tRNA-Ala 2025840..2025915 Neisseria meningitidis Z2491 3233586 NMAt55 tRNA NMAt55 NC_003116.1 2080990 2081065 R tRNA-Phe complement(2080990..2081065) Neisseria meningitidis Z2491 3233587 NMAt56 tRNA NMAt56 NC_003116.1 2107393 2107464 R tRNA-Arg complement(2107393..2107464) Neisseria meningitidis Z2491 3233588 NMAt57 tRNA NMAt57 NC_003116.1 2134520 2134595 R tRNA-Ala complement(2134520..2134595) Neisseria meningitidis Z2491 3233591 NMAt58 tRNA NMAt58 NC_003116.1 2134602 2134678 R tRNA-Ile complement(2134602..2134678) Neisseria meningitidis Z2491 3233592 NMAr01 rRNA NMAr01 NC_003116.1 194574 194690 R 5S ribosomal RNA complement(194574..194690) Neisseria meningitidis Z2491 3233601 NMAr02 rRNA NMAr02 NC_003116.1 194784 197686 R 23S ribosomal RNA complement(194784..197686) Neisseria meningitidis Z2491 3233602 NMAr03 rRNA NMAr03 NC_003116.1 198339 199883 R 16S ribosomal RNA complement(198339..199883) Neisseria meningitidis Z2491 3233605 NMAr04 rRNA NMAr04 NC_003116.1 391349 392893 D 16S ribosomal RNA 391349..392893 Neisseria meningitidis Z2491 3233611 NMAr05 rRNA NMAr05 NC_003116.1 393546 396448 D 23S ribosomal RNA 393546..396448 Neisseria meningitidis Z2491 3233614 NMAr06 rRNA NMAr06 NC_003116.1 396542 396658 D 5S ribosomal RNA 396542..396658 Neisseria meningitidis Z2491 3233615 NMAr07 rRNA NMAr07 NC_003116.1 1841585 1841701 R 5S ribosomal RNA complement(1841585..1841701) Neisseria meningitidis Z2491 3233577 NMAr08 rRNA NMAr08 NC_003116.1 1841795 1844697 R 23S ribosomal RNA complement(1841795..1844697) Neisseria meningitidis Z2491 3233578 NMAr09 rRNA NMAr09 NC_003116.1 1845350 1846894 R 16S ribosomal RNA complement(1845350..1846894) Neisseria meningitidis Z2491 3233581 NMAr10 rRNA NMAr10 NC_003116.1 2131012 2131128 R 5S ribosomal RNA complement(2131012..2131128) Neisseria meningitidis Z2491 3233589 NMAr11 rRNA NMAr11 NC_003116.1 2131222 2134124 R 23S ribosomal RNA complement(2131222..2134124) Neisseria meningitidis Z2491 3233590 NMAr12 rRNA NMAr12 NC_003116.1 2134777 2136321 R 16S ribosomal RNA complement(2134777..2136321) Neisseria meningitidis Z2491 3233593