-- dump date   	20140619_163938
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
700598000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
700598000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
700598000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598000004	Walker A motif; other site
700598000005	ATP binding site [chemical binding]; other site
700598000006	Walker B motif; other site
700598000007	arginine finger; other site
700598000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
700598000009	DnaA box-binding interface [nucleotide binding]; other site
700598000010	CsbD-like; Region: CsbD; cl17424
700598000011	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598000012	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598000013	ligand binding site [chemical binding]; other site
700598000014	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
700598000015	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
700598000016	Entericidin EcnA/B family; Region: Entericidin; cl02322
700598000017	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
700598000018	dimerization interface [polypeptide binding]; other site
700598000019	metal binding site [ion binding]; metal-binding site
700598000020	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
700598000021	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598000022	putative homodimer interface [polypeptide binding]; other site
700598000023	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
700598000024	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700598000025	UDP-galactopyranose mutase; Region: GLF; pfam03275
700598000026	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
700598000027	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
700598000028	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
700598000029	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
700598000030	catalytic residues [active]
700598000031	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
700598000032	dimanganese center [ion binding]; other site
700598000033	MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar...; Region: MIT; cl00299
700598000034	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
700598000035	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
700598000036	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598000037	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598000038	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700598000039	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
700598000040	putative di-iron ligands [ion binding]; other site
700598000041	B12 binding domain; Region: B12-binding; pfam02310
700598000042	B12 binding site [chemical binding]; other site
700598000043	Radical SAM superfamily; Region: Radical_SAM; pfam04055
700598000044	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598000045	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598000046	CheB methylesterase; Region: CheB_methylest; pfam01339
700598000047	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
700598000048	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
700598000049	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
700598000050	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
700598000051	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598000052	putative active site [active]
700598000053	heme pocket [chemical binding]; other site
700598000054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598000055	dimer interface [polypeptide binding]; other site
700598000056	phosphorylation site [posttranslational modification]
700598000057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598000058	ATP binding site [chemical binding]; other site
700598000059	Mg2+ binding site [ion binding]; other site
700598000060	G-X-G motif; other site
700598000061	Response regulator receiver domain; Region: Response_reg; pfam00072
700598000062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598000063	active site
700598000064	phosphorylation site [posttranslational modification]
700598000065	intermolecular recognition site; other site
700598000066	dimerization interface [polypeptide binding]; other site
700598000067	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598000068	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598000069	potential frameshift: common BLAST hit: gi|146299778|ref|YP_001194369.1| histidine kinase
700598000070	Response regulator receiver domain; Region: Response_reg; pfam00072
700598000071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598000072	active site
700598000073	phosphorylation site [posttranslational modification]
700598000074	intermolecular recognition site; other site
700598000075	dimerization interface [polypeptide binding]; other site
700598000076	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598000077	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598000078	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598000079	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598000080	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598000081	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598000082	dimer interface [polypeptide binding]; other site
700598000083	phosphorylation site [posttranslational modification]
700598000084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598000085	ATP binding site [chemical binding]; other site
700598000086	Mg2+ binding site [ion binding]; other site
700598000087	G-X-G motif; other site
700598000088	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
700598000089	putative substrate binding site [chemical binding]; other site
700598000090	active site
700598000091	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
700598000092	active site
700598000093	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598000094	sugar binding site [chemical binding]; other site
700598000095	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
700598000096	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598000097	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598000098	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598000099	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598000100	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598000101	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598000102	SusD family; Region: SusD; pfam07980
700598000103	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
700598000104	active site
700598000105	Amyloid A4 N-terminal heparin-binding; Region: APP_N; pfam02177
700598000106	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
700598000107	amphipathic channel; other site
700598000108	Asn-Pro-Ala signature motifs; other site
700598000109	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
700598000110	active site clefts [active]
700598000111	zinc binding site [ion binding]; other site
700598000112	dimer interface [polypeptide binding]; other site
700598000113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598000114	dimer interface [polypeptide binding]; other site
700598000115	phosphorylation site [posttranslational modification]
700598000116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598000117	ATP binding site [chemical binding]; other site
700598000118	Mg2+ binding site [ion binding]; other site
700598000119	G-X-G motif; other site
700598000120	Response regulator receiver domain; Region: Response_reg; pfam00072
700598000121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598000122	active site
700598000123	phosphorylation site [posttranslational modification]
700598000124	intermolecular recognition site; other site
700598000125	dimerization interface [polypeptide binding]; other site
700598000126	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598000127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598000128	active site
700598000129	phosphorylation site [posttranslational modification]
700598000130	intermolecular recognition site; other site
700598000131	dimerization interface [polypeptide binding]; other site
700598000132	LytTr DNA-binding domain; Region: LytTR; smart00850
700598000133	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
700598000134	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
700598000135	dimerization interface [polypeptide binding]; other site
700598000136	DPS ferroxidase diiron center [ion binding]; other site
700598000137	ion pore; other site
700598000138	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598000139	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598000140	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598000141	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598000142	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598000143	SusD family; Region: SusD; pfam07980
700598000144	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
700598000145	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700598000146	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700598000147	RibD C-terminal domain; Region: RibD_C; cl17279
700598000148	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
700598000149	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700598000150	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598000151	putative DNA binding site [nucleotide binding]; other site
700598000152	putative Zn2+ binding site [ion binding]; other site
700598000153	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700598000154	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
700598000155	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
700598000156	hexamer (dimer of trimers) interface [polypeptide binding]; other site
700598000157	substrate binding site [chemical binding]; other site
700598000158	trimer interface [polypeptide binding]; other site
700598000159	Mn binding site [ion binding]; other site
700598000160	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
700598000161	transketolase; Reviewed; Region: PRK05899
700598000162	TPP-binding site [chemical binding]; other site
700598000163	dimer interface [polypeptide binding]; other site
700598000164	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
700598000165	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700598000166	PYR/PP interface [polypeptide binding]; other site
700598000167	dimer interface [polypeptide binding]; other site
700598000168	TPP binding site [chemical binding]; other site
700598000169	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700598000170	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
700598000171	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
700598000172	ligand binding site [chemical binding]; other site
700598000173	dimerization interface [polypeptide binding]; other site
700598000174	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395
700598000175	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
700598000176	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
700598000177	Walker A/P-loop; other site
700598000178	ATP binding site [chemical binding]; other site
700598000179	Q-loop/lid; other site
700598000180	ABC transporter signature motif; other site
700598000181	Walker B; other site
700598000182	D-loop; other site
700598000183	H-loop/switch region; other site
700598000184	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
700598000185	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700598000186	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
700598000187	TM-ABC transporter signature motif; other site
700598000188	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
700598000189	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700598000190	nucleotide binding site [chemical binding]; other site
700598000191	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
700598000192	putative catalytic site [active]
700598000193	putative metal binding site [ion binding]; other site
700598000194	putative phosphate binding site [ion binding]; other site
700598000195	Family description; Region: VCBS; pfam13517
700598000196	Family description; Region: VCBS; pfam13517
700598000197	Family description; Region: VCBS; pfam13517
700598000198	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
700598000199	Protein of unknown function (DUF1271); Region: DUF1271; pfam06902
700598000200	Right handed beta helix region; Region: Beta_helix; pfam13229
700598000201	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598000202	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
700598000203	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
700598000204	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
700598000205	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
700598000206	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
700598000207	DinB family; Region: DinB; cl17821
700598000208	DinB superfamily; Region: DinB_2; pfam12867
700598000209	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
700598000210	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
700598000211	Substrate binding site; other site
700598000212	Cupin domain; Region: Cupin_2; cl17218
700598000213	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
700598000214	SLBB domain; Region: SLBB; pfam10531
700598000215	Chain length determinant protein; Region: Wzz; cl15801
700598000216	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
700598000217	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
700598000218	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
700598000219	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700598000220	Transcription antiterminator [Transcription]; Region: NusG; COG0250
700598000221	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
700598000222	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
700598000223	heterodimer interface [polypeptide binding]; other site
700598000224	homodimer interface [polypeptide binding]; other site
700598000225	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
700598000226	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
700598000227	NADP-binding site; other site
700598000228	homotetramer interface [polypeptide binding]; other site
700598000229	substrate binding site [chemical binding]; other site
700598000230	homodimer interface [polypeptide binding]; other site
700598000231	active site
700598000232	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
700598000233	O-Antigen ligase; Region: Wzy_C; pfam04932
700598000234	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
700598000235	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
700598000236	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598000237	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598000238	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598000239	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598000240	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598000241	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598000242	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
700598000243	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
700598000244	trimer interface [polypeptide binding]; other site
700598000245	active site
700598000246	substrate binding site [chemical binding]; other site
700598000247	CoA binding site [chemical binding]; other site
700598000248	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
700598000249	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
700598000250	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
700598000251	Bacterial sugar transferase; Region: Bac_transf; pfam02397
700598000252	VanZ like family; Region: VanZ; cl01971
700598000253	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598000254	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598000255	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
700598000256	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
700598000257	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
700598000258	NAD(P) binding site [chemical binding]; other site
700598000259	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598000260	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598000261	ligand binding site [chemical binding]; other site
700598000262	flexible hinge region; other site
700598000263	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
700598000264	MPN+ (JAMM) motif; other site
700598000265	Zinc-binding site [ion binding]; other site
700598000266	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
700598000267	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
700598000268	ATP binding site [chemical binding]; other site
700598000269	substrate interface [chemical binding]; other site
700598000270	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700598000271	active site residue [active]
700598000272	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
700598000273	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
700598000274	active site
700598000275	catalytic residues [active]
700598000276	metal binding site [ion binding]; metal-binding site
700598000277	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
700598000278	tartrate dehydrogenase; Region: TTC; TIGR02089
700598000279	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
700598000280	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
700598000281	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
700598000282	PYR/PP interface [polypeptide binding]; other site
700598000283	dimer interface [polypeptide binding]; other site
700598000284	TPP binding site [chemical binding]; other site
700598000285	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
700598000286	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
700598000287	TPP-binding site [chemical binding]; other site
700598000288	dimer interface [polypeptide binding]; other site
700598000289	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598000290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598000291	S-adenosylmethionine binding site [chemical binding]; other site
700598000292	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
700598000293	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
700598000294	putative valine binding site [chemical binding]; other site
700598000295	dimer interface [polypeptide binding]; other site
700598000296	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
700598000297	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
700598000298	ketol-acid reductoisomerase; Region: ilvC; TIGR00465
700598000299	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
700598000300	threonine dehydratase; Validated; Region: PRK08639
700598000301	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
700598000302	tetramer interface [polypeptide binding]; other site
700598000303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598000304	catalytic residue [active]
700598000305	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
700598000306	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
700598000307	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
700598000308	active site
700598000309	dimer interface [polypeptide binding]; other site
700598000310	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
700598000311	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
700598000312	active site
700598000313	FMN binding site [chemical binding]; other site
700598000314	substrate binding site [chemical binding]; other site
700598000315	3Fe-4S cluster binding site [ion binding]; other site
700598000316	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
700598000317	domain interface; other site
700598000318	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
700598000319	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598000320	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
700598000321	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
700598000322	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
700598000323	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
700598000324	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
700598000325	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
700598000326	putative catalytic residues [active]
700598000327	nucleotide binding site [chemical binding]; other site
700598000328	aspartate binding site [chemical binding]; other site
700598000329	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
700598000330	dimer interface [polypeptide binding]; other site
700598000331	putative threonine allosteric regulatory site; other site
700598000332	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
700598000333	putative threonine allosteric regulatory site; other site
700598000334	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
700598000335	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
700598000336	homoserine kinase; Provisional; Region: PRK01212
700598000337	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
700598000338	threonine synthase; Validated; Region: PRK09225
700598000339	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
700598000340	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598000341	catalytic residue [active]
700598000342	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
700598000343	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
700598000344	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
700598000345	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
700598000346	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
700598000347	homodimer interface [polypeptide binding]; other site
700598000348	substrate-cofactor binding pocket; other site
700598000349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598000350	catalytic residue [active]
700598000351	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598000352	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598000353	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598000354	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598000355	ligand binding site [chemical binding]; other site
700598000356	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
700598000357	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
700598000358	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
700598000359	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
700598000360	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
700598000361	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598000362	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700598000363	Coenzyme A binding pocket [chemical binding]; other site
700598000364	recombination factor protein RarA; Reviewed; Region: PRK13342
700598000365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598000366	Walker A motif; other site
700598000367	ATP binding site [chemical binding]; other site
700598000368	Walker B motif; other site
700598000369	arginine finger; other site
700598000370	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
700598000371	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
700598000372	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
700598000373	dimer interface [polypeptide binding]; other site
700598000374	anticodon binding site; other site
700598000375	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
700598000376	homodimer interface [polypeptide binding]; other site
700598000377	motif 1; other site
700598000378	active site
700598000379	motif 2; other site
700598000380	GAD domain; Region: GAD; pfam02938
700598000381	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700598000382	active site
700598000383	motif 3; other site
700598000384	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
700598000385	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
700598000386	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
700598000387	potential frameshift: common BLAST hit: gi|255036967|ref|YP_003087588.1| alpha-2-macroglobulin domain-containing protein
700598000388	Alpha-2-macroglobulin family; Region: A2M; pfam00207
700598000389	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
700598000390	MG2 domain; Region: A2M_N; pfam01835
700598000391	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
700598000392	CoA binding domain; Region: CoA_binding; smart00881
700598000393	CoA-ligase; Region: Ligase_CoA; pfam00549
700598000394	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
700598000395	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
700598000396	Walker A/P-loop; other site
700598000397	ATP binding site [chemical binding]; other site
700598000398	Q-loop/lid; other site
700598000399	ABC transporter signature motif; other site
700598000400	Walker B; other site
700598000401	D-loop; other site
700598000402	H-loop/switch region; other site
700598000403	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700598000404	Permease; Region: Permease; pfam02405
700598000405	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
700598000406	Malic enzyme, N-terminal domain; Region: malic; pfam00390
700598000407	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
700598000408	putative NAD(P) binding site [chemical binding]; other site
700598000409	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
700598000410	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598000411	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
700598000412	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700598000413	Walker A/P-loop; other site
700598000414	ATP binding site [chemical binding]; other site
700598000415	Q-loop/lid; other site
700598000416	ABC transporter signature motif; other site
700598000417	Walker B; other site
700598000418	D-loop; other site
700598000419	H-loop/switch region; other site
700598000420	Predicted transcriptional regulators [Transcription]; Region: COG1725
700598000421	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598000422	DNA-binding site [nucleotide binding]; DNA binding site
700598000423	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
700598000424	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
700598000425	metal binding site [ion binding]; metal-binding site
700598000426	dimer interface [polypeptide binding]; other site
700598000427	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
700598000428	Putative addiction module component; Region: Unstab_antitox; cl09921
700598000429	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
700598000430	intersubunit interface [polypeptide binding]; other site
700598000431	active site
700598000432	catalytic residue [active]
700598000433	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598000434	Amidohydrolase; Region: Amidohydro_4; pfam13147
700598000435	active site
700598000436	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
700598000437	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
700598000438	active site
700598000439	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
700598000440	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598000441	active site
700598000442	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
700598000443	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
700598000444	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
700598000445	Leucine carboxyl methyltransferase; Region: LCM; cl01306
700598000446	Predicted periplasmic protein [Function unknown]; Region: COG3698
700598000447	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
700598000448	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598000449	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
700598000450	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
700598000451	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598000452	nucleotide binding region [chemical binding]; other site
700598000453	ATP-binding site [chemical binding]; other site
700598000454	SEC-C motif; Region: SEC-C; pfam02810
700598000455	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
700598000456	DNA protecting protein DprA; Region: dprA; TIGR00732
700598000457	TPR repeat; Region: TPR_11; pfam13414
700598000458	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598000459	binding surface
700598000460	TPR motif; other site
700598000461	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
700598000462	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598000463	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598000464	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598000465	ligand binding site [chemical binding]; other site
700598000466	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
700598000467	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598000468	FeS/SAM binding site; other site
700598000469	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185
700598000470	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
700598000471	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
700598000472	homodimer interface [polypeptide binding]; other site
700598000473	NADP binding site [chemical binding]; other site
700598000474	substrate binding site [chemical binding]; other site
700598000475	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
700598000476	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598000477	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598000478	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598000479	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598000480	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598000481	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
700598000482	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598000483	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598000484	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598000485	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598000486	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598000487	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598000488	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598000489	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
700598000490	hypothetical protein; Reviewed; Region: PRK00024
700598000491	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
700598000492	MPN+ (JAMM) motif; other site
700598000493	Zinc-binding site [ion binding]; other site
700598000494	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
700598000495	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
700598000496	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
700598000497	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700598000498	active site
700598000499	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
700598000500	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
700598000501	5S rRNA interface [nucleotide binding]; other site
700598000502	CTC domain interface [polypeptide binding]; other site
700598000503	L16 interface [polypeptide binding]; other site
700598000504	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
700598000505	putative active site [active]
700598000506	catalytic residue [active]
700598000507	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
700598000508	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
700598000509	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
700598000510	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
700598000511	tetramer interface [polypeptide binding]; other site
700598000512	TPP-binding site [chemical binding]; other site
700598000513	heterodimer interface [polypeptide binding]; other site
700598000514	phosphorylation loop region [posttranslational modification]
700598000515	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
700598000516	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
700598000517	PYR/PP interface [polypeptide binding]; other site
700598000518	dimer interface [polypeptide binding]; other site
700598000519	TPP binding site [chemical binding]; other site
700598000520	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700598000521	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
700598000522	DNA binding residues [nucleotide binding]
700598000523	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
700598000524	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
700598000525	purine nucleoside phosphorylase; Provisional; Region: PRK08202
700598000526	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700598000527	Sulfatase; Region: Sulfatase; pfam00884
700598000528	Uncharacterized conserved protein [Function unknown]; Region: COG1262
700598000529	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
700598000530	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
700598000531	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
700598000532	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598000533	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598000534	DNA binding site [nucleotide binding]
700598000535	domain linker motif; other site
700598000536	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598000537	dimerization interface [polypeptide binding]; other site
700598000538	ligand binding site [chemical binding]; other site
700598000539	PAS fold; Region: PAS_4; pfam08448
700598000540	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
700598000541	putative active site [active]
700598000542	heme pocket [chemical binding]; other site
700598000543	PAS domain S-box; Region: sensory_box; TIGR00229
700598000544	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598000545	putative active site [active]
700598000546	heme pocket [chemical binding]; other site
700598000547	PAS fold; Region: PAS_3; pfam08447
700598000548	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598000549	putative active site [active]
700598000550	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598000551	heme pocket [chemical binding]; other site
700598000552	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598000553	dimer interface [polypeptide binding]; other site
700598000554	phosphorylation site [posttranslational modification]
700598000555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598000556	ATP binding site [chemical binding]; other site
700598000557	Mg2+ binding site [ion binding]; other site
700598000558	G-X-G motif; other site
700598000559	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
700598000560	Methylamine utilisation protein MauE; Region: MauE; pfam07291
700598000561	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598000562	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598000563	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598000564	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598000565	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598000566	FecR protein; Region: FecR; pfam04773
700598000567	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598000568	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598000569	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598000570	DNA binding residues [nucleotide binding]
700598000571	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598000572	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
700598000573	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
700598000574	MOSC domain; Region: MOSC; pfam03473
700598000575	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
700598000576	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
700598000577	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598000578	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
700598000579	Uncharacterized conserved protein [Function unknown]; Region: COG5276
700598000580	Uncharacterized conserved protein [Function unknown]; Region: COG5276
700598000581	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
700598000582	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
700598000583	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598000584	FtsX-like permease family; Region: FtsX; pfam02687
700598000585	FtsX-like permease family; Region: FtsX; pfam02687
700598000586	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700598000587	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700598000588	Walker A/P-loop; other site
700598000589	ATP binding site [chemical binding]; other site
700598000590	Q-loop/lid; other site
700598000591	ABC transporter signature motif; other site
700598000592	Walker B; other site
700598000593	D-loop; other site
700598000594	H-loop/switch region; other site
700598000595	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
700598000596	active site
700598000597	catalytic triad [active]
700598000598	oxyanion hole [active]
700598000599	switch loop; other site
700598000600	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
700598000601	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598000602	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700598000603	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598000604	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
700598000605	putative ABC transporter; Region: ycf24; CHL00085
700598000606	FeS assembly ATPase SufC; Region: sufC; TIGR01978
700598000607	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
700598000608	Walker A/P-loop; other site
700598000609	ATP binding site [chemical binding]; other site
700598000610	Q-loop/lid; other site
700598000611	ABC transporter signature motif; other site
700598000612	Walker B; other site
700598000613	D-loop; other site
700598000614	H-loop/switch region; other site
700598000615	FeS assembly protein SufD; Region: sufD; TIGR01981
700598000616	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
700598000617	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
700598000618	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
700598000619	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598000620	catalytic residue [active]
700598000621	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
700598000622	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
700598000623	Rrf2 family protein; Region: rrf2_super; TIGR00738
700598000624	Transcriptional regulator; Region: Rrf2; pfam02082
700598000625	Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248
700598000626	active site
700598000627	S2 subsite; other site
700598000628	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
700598000629	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598000630	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598000631	FAD binding domain; Region: FAD_binding_3; pfam01494
700598000632	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700598000633	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598000634	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598000635	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598000636	DNA binding residues [nucleotide binding]
700598000637	FecR protein; Region: FecR; pfam04773
700598000638	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598000639	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598000640	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598000641	DNA binding residues [nucleotide binding]
700598000642	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598000643	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598000644	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598000645	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598000646	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598000647	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598000648	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598000649	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598000650	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
700598000651	active site
700598000652	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
700598000653	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598000654	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700598000655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598000656	non-specific DNA binding site [nucleotide binding]; other site
700598000657	salt bridge; other site
700598000658	sequence-specific DNA binding site [nucleotide binding]; other site
700598000659	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
700598000660	Catalytic site [active]
700598000661	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700598000662	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598000663	non-specific DNA binding site [nucleotide binding]; other site
700598000664	salt bridge; other site
700598000665	sequence-specific DNA binding site [nucleotide binding]; other site
700598000666	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
700598000667	Catalytic site [active]
700598000668	Response regulator receiver domain; Region: Response_reg; pfam00072
700598000669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598000670	active site
700598000671	phosphorylation site [posttranslational modification]
700598000672	intermolecular recognition site; other site
700598000673	dimerization interface [polypeptide binding]; other site
700598000674	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
700598000675	putative binding surface; other site
700598000676	active site
700598000677	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
700598000678	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
700598000679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598000680	ATP binding site [chemical binding]; other site
700598000681	Mg2+ binding site [ion binding]; other site
700598000682	G-X-G motif; other site
700598000683	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
700598000684	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
700598000685	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
700598000686	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
700598000687	dimerization interface [polypeptide binding]; other site
700598000688	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
700598000689	dimer interface [polypeptide binding]; other site
700598000690	putative CheW interface [polypeptide binding]; other site
700598000691	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
700598000692	HAMP domain; Region: HAMP; pfam00672
700598000693	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
700598000694	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
700598000695	dimer interface [polypeptide binding]; other site
700598000696	putative CheW interface [polypeptide binding]; other site
700598000697	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
700598000698	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
700598000699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598000700	S-adenosylmethionine binding site [chemical binding]; other site
700598000701	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598000702	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598000703	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598000704	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598000705	Predicted membrane protein [Function unknown]; Region: COG3503
700598000706	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
700598000707	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598000708	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598000709	ligand binding site [chemical binding]; other site
700598000710	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700598000711	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
700598000712	Peptidase family M28; Region: Peptidase_M28; pfam04389
700598000713	metal binding site [ion binding]; metal-binding site
700598000714	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700598000715	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700598000716	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598000717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598000718	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
700598000719	EamA-like transporter family; Region: EamA; pfam00892
700598000720	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700598000721	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
700598000722	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
700598000723	putative hydrophobic ligand binding site [chemical binding]; other site
700598000724	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598000725	dimerization interface [polypeptide binding]; other site
700598000726	putative DNA binding site [nucleotide binding]; other site
700598000727	putative Zn2+ binding site [ion binding]; other site
700598000728	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
700598000729	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
700598000730	PQQ-like domain; Region: PQQ_2; pfam13360
700598000731	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
700598000732	Protein of unknown function; Region: DUF3971; pfam13116
700598000733	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
700598000734	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
700598000735	Peptidase family M1; Region: Peptidase_M1; pfam01433
700598000736	Zn binding site [ion binding]; other site
700598000737	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598000738	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
700598000739	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
700598000740	conserved cys residue [active]
700598000741	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598000742	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598000743	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
700598000744	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
700598000745	Histidine kinase; Region: His_kinase; pfam06580
700598000746	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598000747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598000748	active site
700598000749	phosphorylation site [posttranslational modification]
700598000750	intermolecular recognition site; other site
700598000751	dimerization interface [polypeptide binding]; other site
700598000752	LytTr DNA-binding domain; Region: LytTR; smart00850
700598000753	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598000754	FtsX-like permease family; Region: FtsX; pfam02687
700598000755	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598000756	FtsX-like permease family; Region: FtsX; pfam02687
700598000757	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
700598000758	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
700598000759	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
700598000760	Part of AAA domain; Region: AAA_19; pfam13245
700598000761	Family description; Region: UvrD_C_2; pfam13538
700598000762	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598000763	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598000764	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
700598000765	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
700598000766	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598000767	NAD(P) binding site [chemical binding]; other site
700598000768	active site
700598000769	short chain dehydrogenase; Provisional; Region: PRK08263
700598000770	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598000771	NADP binding site [chemical binding]; other site
700598000772	active site
700598000773	steroid binding site; other site
700598000774	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598000775	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598000776	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
700598000777	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598000778	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
700598000779	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
700598000780	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598000781	active site
700598000782	nucleotide binding site [chemical binding]; other site
700598000783	HIGH motif; other site
700598000784	KMSKS motif; other site
700598000785	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
700598000786	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
700598000787	aspartate aminotransferase; Provisional; Region: PRK07568
700598000788	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598000789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598000790	homodimer interface [polypeptide binding]; other site
700598000791	catalytic residue [active]
700598000792	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
700598000793	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
700598000794	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
700598000795	tetramer interface [polypeptide binding]; other site
700598000796	TPP-binding site [chemical binding]; other site
700598000797	heterodimer interface [polypeptide binding]; other site
700598000798	phosphorylation loop region [posttranslational modification]
700598000799	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
700598000800	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
700598000801	PYR/PP interface [polypeptide binding]; other site
700598000802	dimer interface [polypeptide binding]; other site
700598000803	TPP binding site [chemical binding]; other site
700598000804	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700598000805	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
700598000806	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
700598000807	hypothetical protein; Provisional; Region: PRK12378
700598000808	amino acid transporter; Region: 2A0306; TIGR00909
700598000809	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
700598000810	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
700598000811	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
700598000812	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
700598000813	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
700598000814	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598000815	putative substrate translocation pore; other site
700598000816	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598000817	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
700598000818	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
700598000819	putative active site [active]
700598000820	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
700598000821	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598000822	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598000823	YCII-related domain; Region: YCII; cl00999
700598000824	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598000825	malate dehydrogenase; Reviewed; Region: PRK06223
700598000826	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
700598000827	dimer interface [polypeptide binding]; other site
700598000828	NAD(P) binding site [chemical binding]; other site
700598000829	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700598000830	substrate binding site [chemical binding]; other site
700598000831	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
700598000832	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598000833	Penicillinase repressor; Region: Pencillinase_R; pfam03965
700598000834	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
700598000835	elongation factor P; Validated; Region: PRK00529
700598000836	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
700598000837	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
700598000838	RNA binding site [nucleotide binding]; other site
700598000839	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
700598000840	RNA binding site [nucleotide binding]; other site
700598000841	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
700598000842	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
700598000843	carboxyltransferase (CT) interaction site; other site
700598000844	biotinylation site [posttranslational modification]; other site
700598000845	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
700598000846	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700598000847	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
700598000848	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
700598000849	LytB protein; Region: LYTB; cl00507
700598000850	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
700598000851	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
700598000852	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
700598000853	active site
700598000854	catalytic site [active]
700598000855	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
700598000856	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
700598000857	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700598000858	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700598000859	protein binding site [polypeptide binding]; other site
700598000860	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700598000861	protein binding site [polypeptide binding]; other site
700598000862	4Fe-4S binding domain; Region: Fer4; pfam00037
700598000863	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
700598000864	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
700598000865	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
700598000866	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700598000867	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700598000868	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700598000869	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700598000870	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700598000871	active site residue [active]
700598000872	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700598000873	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700598000874	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700598000875	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598000876	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598000877	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598000878	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
700598000879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
700598000880	non-specific DNA binding site [nucleotide binding]; other site
700598000881	salt bridge; other site
700598000882	sequence-specific DNA binding site [nucleotide binding]; other site
700598000883	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
700598000884	GIY-YIG motif/motif A; other site
700598000885	putative active site [active]
700598000886	putative metal binding site [ion binding]; other site
700598000887	GTPase Era; Reviewed; Region: era; PRK00089
700598000888	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
700598000889	G1 box; other site
700598000890	GTP/Mg2+ binding site [chemical binding]; other site
700598000891	Switch I region; other site
700598000892	G2 box; other site
700598000893	Switch II region; other site
700598000894	G3 box; other site
700598000895	G4 box; other site
700598000896	G5 box; other site
700598000897	KH domain; Region: KH_2; pfam07650
700598000898	GTP-binding protein Der; Reviewed; Region: PRK00093
700598000899	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
700598000900	G1 box; other site
700598000901	GTP/Mg2+ binding site [chemical binding]; other site
700598000902	Switch I region; other site
700598000903	G2 box; other site
700598000904	Switch II region; other site
700598000905	G3 box; other site
700598000906	G4 box; other site
700598000907	G5 box; other site
700598000908	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
700598000909	G1 box; other site
700598000910	GTP/Mg2+ binding site [chemical binding]; other site
700598000911	Switch I region; other site
700598000912	G2 box; other site
700598000913	G3 box; other site
700598000914	Switch II region; other site
700598000915	G4 box; other site
700598000916	G5 box; other site
700598000917	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
700598000918	putative trimer interface [polypeptide binding]; other site
700598000919	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
700598000920	putative CoA binding site [chemical binding]; other site
700598000921	putative trimer interface [polypeptide binding]; other site
700598000922	putative CoA binding site [chemical binding]; other site
700598000923	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
700598000924	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
700598000925	glutaminase active site [active]
700598000926	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
700598000927	dimer interface [polypeptide binding]; other site
700598000928	active site
700598000929	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
700598000930	dimer interface [polypeptide binding]; other site
700598000931	active site
700598000932	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700598000933	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598000934	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
700598000935	MgtE intracellular N domain; Region: MgtE_N; pfam03448
700598000936	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
700598000937	Divalent cation transporter; Region: MgtE; pfam01769
700598000938	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
700598000939	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598000940	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598000941	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598000942	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598000943	DNA binding residues [nucleotide binding]
700598000944	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
700598000945	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
700598000946	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
700598000947	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598000948	binding surface
700598000949	TPR motif; other site
700598000950	TPR repeat; Region: TPR_11; pfam13414
700598000951	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598000952	binding surface
700598000953	TPR repeat; Region: TPR_11; pfam13414
700598000954	TPR motif; other site
700598000955	TPR repeat; Region: TPR_11; pfam13414
700598000956	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
700598000957	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
700598000958	substrate binding site [chemical binding]; other site
700598000959	hexamer interface [polypeptide binding]; other site
700598000960	metal binding site [ion binding]; metal-binding site
700598000961	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598000962	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598000963	S-adenosylmethionine binding site [chemical binding]; other site
700598000964	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598000965	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598000966	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700598000967	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598000968	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598000969	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598000970	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
700598000971	active site
700598000972	hydrophilic channel; other site
700598000973	dimerization interface [polypeptide binding]; other site
700598000974	catalytic residues [active]
700598000975	active site lid [active]
700598000976	Predicted acetyltransferase [General function prediction only]; Region: COG2388
700598000977	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
700598000978	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
700598000979	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
700598000980	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
700598000981	Glutamine amidotransferase class-I; Region: GATase; pfam00117
700598000982	glutamine binding [chemical binding]; other site
700598000983	catalytic triad [active]
700598000984	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
700598000985	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
700598000986	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
700598000987	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
700598000988	active site
700598000989	ribulose/triose binding site [chemical binding]; other site
700598000990	phosphate binding site [ion binding]; other site
700598000991	substrate (anthranilate) binding pocket [chemical binding]; other site
700598000992	product (indole) binding pocket [chemical binding]; other site
700598000993	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
700598000994	active site
700598000995	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
700598000996	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598000997	Coenzyme A binding pocket [chemical binding]; other site
700598000998	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
700598000999	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
700598001000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598001001	catalytic residue [active]
700598001002	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
700598001003	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
700598001004	substrate binding site [chemical binding]; other site
700598001005	active site
700598001006	catalytic residues [active]
700598001007	heterodimer interface [polypeptide binding]; other site
700598001008	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
700598001009	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
700598001010	putative active site [active]
700598001011	oxyanion strand; other site
700598001012	catalytic triad [active]
700598001013	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
700598001014	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598001015	Coenzyme A binding pocket [chemical binding]; other site
700598001016	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
700598001017	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
700598001018	catalytic residues [active]
700598001019	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
700598001020	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
700598001021	substrate binding site [chemical binding]; other site
700598001022	glutamase interaction surface [polypeptide binding]; other site
700598001023	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
700598001024	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
700598001025	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
700598001026	metal binding site [ion binding]; metal-binding site
700598001027	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
700598001028	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598001029	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598001030	catalytic residues [active]
700598001031	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
700598001032	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
700598001033	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598001034	binding surface
700598001035	TPR motif; other site
700598001036	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
700598001037	Transglycosylase; Region: Transgly; pfam00912
700598001038	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
700598001039	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
700598001040	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
700598001041	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
700598001042	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
700598001043	SprT homologues; Region: SprT; cl01182
700598001044	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700598001045	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598001046	Coenzyme A binding pocket [chemical binding]; other site
700598001047	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
700598001048	substrate binding site [chemical binding]; other site
700598001049	activation loop (A-loop); other site
700598001050	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
700598001051	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
700598001052	CoA-ligase; Region: Ligase_CoA; pfam00549
700598001053	purine nucleoside phosphorylase; Provisional; Region: PRK08202
700598001054	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
700598001055	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
700598001056	Outer membrane efflux protein; Region: OEP; pfam02321
700598001057	Outer membrane efflux protein; Region: OEP; pfam02321
700598001058	HlyD family secretion protein; Region: HlyD_2; pfam12700
700598001059	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598001060	Cupin domain; Region: Cupin_2; pfam07883
700598001061	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
700598001062	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
700598001063	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
700598001064	conserved cys residue [active]
700598001065	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
700598001066	active site
700598001067	catalytic triad [active]
700598001068	oxyanion hole [active]
700598001069	ethanolamine permease; Region: 2A0305; TIGR00908
700598001070	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
700598001071	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
700598001072	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
700598001073	carboxylate-amine ligase; Provisional; Region: PRK13515
700598001074	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
700598001075	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
700598001076	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700598001077	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
700598001078	Putative esterase; Region: Esterase; pfam00756
700598001079	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598001080	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598001081	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598001082	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598001083	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598001084	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
700598001085	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
700598001086	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
700598001087	dimerization interface [polypeptide binding]; other site
700598001088	active site
700598001089	Family of unknown function (DUF490); Region: DUF490; pfam04357
700598001090	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
700598001091	DinB superfamily; Region: DinB_2; pfam12867
700598001092	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
700598001093	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
700598001094	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
700598001095	putative active site [active]
700598001096	Zn binding site [ion binding]; other site
700598001097	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
700598001098	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
700598001099	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494
700598001100	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
700598001101	Na binding site [ion binding]; other site
700598001102	MarR family; Region: MarR_2; pfam12802
700598001103	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700598001104	MarR family; Region: MarR_2; cl17246
700598001105	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
700598001106	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598001107	Coenzyme A binding pocket [chemical binding]; other site
700598001108	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
700598001109	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598001110	TPR repeat; Region: TPR_11; pfam13414
700598001111	binding surface
700598001112	TPR motif; other site
700598001113	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001114	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598001115	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598001116	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598001117	DNA binding residues [nucleotide binding]
700598001118	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001119	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001120	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001121	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001122	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
700598001123	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
700598001124	active site
700598001125	Int/Topo IB signature motif; other site
700598001126	Flagellin N-methylase; Region: FliB; pfam03692
700598001127	hypothetical protein; Reviewed; Region: PRK12497
700598001128	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
700598001129	mannose-6-phosphate isomerase; Region: PLN02288
700598001130	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
700598001131	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
700598001132	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598001133	ATP binding site [chemical binding]; other site
700598001134	putative Mg++ binding site [ion binding]; other site
700598001135	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598001136	nucleotide binding region [chemical binding]; other site
700598001137	ATP-binding site [chemical binding]; other site
700598001138	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
700598001139	RNA/DNA hybrid binding site [nucleotide binding]; other site
700598001140	active site
700598001141	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
700598001142	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
700598001143	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
700598001144	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
700598001145	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
700598001146	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
700598001147	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598001148	S-adenosylmethionine binding site [chemical binding]; other site
700598001149	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
700598001150	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
700598001151	trimer interface [polypeptide binding]; other site
700598001152	active site
700598001153	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
700598001154	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
700598001155	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
700598001156	FecR protein; Region: FecR; pfam04773
700598001157	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598001158	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598001159	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001160	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598001161	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598001162	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598001163	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598001164	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598001165	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598001166	DNA binding residues [nucleotide binding]
700598001167	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
700598001168	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
700598001169	active site
700598001170	homotetramer interface [polypeptide binding]; other site
700598001171	putative OHCU decarboxylase; Provisional; Region: PRK13798
700598001172	hypothetical protein; Provisional; Region: PRK11171
700598001173	Cupin domain; Region: Cupin_2; cl17218
700598001174	Cupin domain; Region: Cupin_2; pfam07883
700598001175	allantoate amidohydrolase; Reviewed; Region: PRK09290
700598001176	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
700598001177	active site
700598001178	metal binding site [ion binding]; metal-binding site
700598001179	dimer interface [polypeptide binding]; other site
700598001180	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
700598001181	allantoinase; Region: allantoinase; TIGR03178
700598001182	active site
700598001183	urate oxidase; Region: urate_oxi; TIGR03383
700598001184	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
700598001185	active site
700598001186	UreD urease accessory protein; Region: UreD; pfam01774
700598001187	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
700598001188	G1 box; other site
700598001189	GTP/Mg2+ binding site [chemical binding]; other site
700598001190	G2 box; other site
700598001191	Switch I region; other site
700598001192	G3 box; other site
700598001193	Switch II region; other site
700598001194	G4 box; other site
700598001195	G5 box; other site
700598001196	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
700598001197	UreF; Region: UreF; pfam01730
700598001198	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
700598001199	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
700598001200	dimer interface [polypeptide binding]; other site
700598001201	catalytic residues [active]
700598001202	urease subunit alpha; Reviewed; Region: ureC; PRK13207
700598001203	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
700598001204	subunit interactions [polypeptide binding]; other site
700598001205	active site
700598001206	flap region; other site
700598001207	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
700598001208	gamma-beta subunit interface [polypeptide binding]; other site
700598001209	alpha-beta subunit interface [polypeptide binding]; other site
700598001210	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
700598001211	alpha-gamma subunit interface [polypeptide binding]; other site
700598001212	beta-gamma subunit interface [polypeptide binding]; other site
700598001213	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
700598001214	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
700598001215	XdhC Rossmann domain; Region: XdhC_C; pfam13478
700598001216	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
700598001217	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
700598001218	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598001219	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
700598001220	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598001221	catalytic loop [active]
700598001222	iron binding site [ion binding]; other site
700598001223	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
700598001224	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
700598001225	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
700598001226	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598001227	dimerization interface [polypeptide binding]; other site
700598001228	putative DNA binding site [nucleotide binding]; other site
700598001229	putative Zn2+ binding site [ion binding]; other site
700598001230	AsnC family; Region: AsnC_trans_reg; pfam01037
700598001231	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
700598001232	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
700598001233	tetrameric interface [polypeptide binding]; other site
700598001234	NAD binding site [chemical binding]; other site
700598001235	catalytic residues [active]
700598001236	hypothetical protein; Provisional; Region: PRK06062
700598001237	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700598001238	inhibitor-cofactor binding pocket; inhibition site
700598001239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598001240	catalytic residue [active]
700598001241	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
700598001242	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
700598001243	Na binding site [ion binding]; other site
700598001244	putative substrate binding site [chemical binding]; other site
700598001245	phenylhydantoinase; Validated; Region: PRK08323
700598001246	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
700598001247	tetramer interface [polypeptide binding]; other site
700598001248	active site
700598001249	mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568
700598001250	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
700598001251	putative active site [active]
700598001252	catalytic triad [active]
700598001253	multimer interface [polypeptide binding]; other site
700598001254	dimer interface [polypeptide binding]; other site
700598001255	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
700598001256	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700598001257	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
700598001258	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
700598001259	homodimer interface [polypeptide binding]; other site
700598001260	active site
700598001261	FMN binding site [chemical binding]; other site
700598001262	substrate binding site [chemical binding]; other site
700598001263	4Fe-4S binding domain; Region: Fer4_6; pfam12837
700598001264	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
700598001265	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
700598001266	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
700598001267	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
700598001268	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
700598001269	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
700598001270	Phage protein D [General function prediction only]; Region: COG3500
700598001271	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
700598001272	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
700598001273	PAAR motif; Region: PAAR_motif; pfam05488
700598001274	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
700598001275	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
700598001276	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
700598001277	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001278	REJ domain; Region: REJ; pfam02010
700598001279	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598001280	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
700598001281	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
700598001282	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700598001283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598001284	Walker A motif; other site
700598001285	ATP binding site [chemical binding]; other site
700598001286	Walker B motif; other site
700598001287	arginine finger; other site
700598001288	Beta/Gamma crystallin; Region: Crystall; cl02528
700598001289	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001290	Beta/Gamma crystallin; Region: Crystall; cl02528
700598001291	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001292	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
700598001293	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
700598001294	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598001295	DNA-binding site [nucleotide binding]; DNA binding site
700598001296	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598001297	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598001298	homodimer interface [polypeptide binding]; other site
700598001299	catalytic residue [active]
700598001300	Response regulator receiver domain; Region: Response_reg; pfam00072
700598001301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598001302	active site
700598001303	phosphorylation site [posttranslational modification]
700598001304	intermolecular recognition site; other site
700598001305	dimerization interface [polypeptide binding]; other site
700598001306	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700598001307	Ycf48-like protein; Provisional; Region: PRK13684
700598001308	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001309	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598001310	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
700598001311	ligand binding site [chemical binding]; other site
700598001312	flexible hinge region; other site
700598001313	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
700598001314	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
700598001315	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001316	MgtE intracellular N domain; Region: MgtE_N; pfam03448
700598001317	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
700598001318	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
700598001319	Divalent cation transporter; Region: MgtE; pfam01769
700598001320	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598001321	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598001322	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598001323	NmrA-like family; Region: NmrA; pfam05368
700598001324	NAD(P) binding site [chemical binding]; other site
700598001325	active site
700598001326	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598001327	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598001328	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598001329	NADH(P)-binding; Region: NAD_binding_10; pfam13460
700598001330	NAD(P) binding site [chemical binding]; other site
700598001331	active site
700598001332	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
700598001333	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598001334	putative NAD(P) binding site [chemical binding]; other site
700598001335	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598001336	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598001337	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
700598001338	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
700598001339	Galactose oxidase, central domain; Region: Kelch_3; cl02701
700598001340	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001341	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
700598001342	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598001343	phosphorylation site [posttranslational modification]
700598001344	dimer interface [polypeptide binding]; other site
700598001345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598001346	ATP binding site [chemical binding]; other site
700598001347	Mg2+ binding site [ion binding]; other site
700598001348	G-X-G motif; other site
700598001349	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598001350	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
700598001351	Probable Catalytic site; other site
700598001352	metal-binding site
700598001353	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
700598001354	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
700598001355	catalytic residues [active]
700598001356	catalytic nucleophile [active]
700598001357	Recombinase; Region: Recombinase; pfam07508
700598001358	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
700598001359	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
700598001360	active site residue [active]
700598001361	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
700598001362	active site residue [active]
700598001363	Tellurite resistance protein TerB; Region: TerB; cl17311
700598001364	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001365	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
700598001366	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
700598001367	active site
700598001368	Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589
700598001369	putative active site [active]
700598001370	catalytic site [active]
700598001371	putative metal binding site [ion binding]; other site
700598001372	Uncharacterized conserved protein [Function unknown]; Region: COG3391
700598001373	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
700598001374	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
700598001375	Phosphoesterase family; Region: Phosphoesterase; pfam04185
700598001376	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700598001377	endonuclease III; Region: ENDO3c; smart00478
700598001378	minor groove reading motif; other site
700598001379	helix-hairpin-helix signature motif; other site
700598001380	active site
700598001381	Sulfatase; Region: Sulfatase; cl17466
700598001382	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700598001383	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598001384	DNA-binding site [nucleotide binding]; DNA binding site
700598001385	UTRA domain; Region: UTRA; pfam07702
700598001386	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
700598001387	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
700598001388	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
700598001389	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
700598001390	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
700598001391	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
700598001392	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
700598001393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598001394	putative substrate translocation pore; other site
700598001395	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700598001396	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700598001397	nucleotide binding site [chemical binding]; other site
700598001398	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
700598001399	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
700598001400	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
700598001401	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598001402	NAD(P) binding site [chemical binding]; other site
700598001403	active site
700598001404	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598001405	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598001406	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
700598001407	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598001408	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598001409	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001410	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598001411	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598001412	RNA ligase; Region: RNA_ligase; pfam09414
700598001413	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700598001414	Zn2+ binding site [ion binding]; other site
700598001415	Mg2+ binding site [ion binding]; other site
700598001416	AAA domain; Region: AAA_33; pfam13671
700598001417	AAA domain; Region: AAA_17; pfam13207
700598001418	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
700598001419	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598001420	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
700598001421	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598001422	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598001423	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
700598001424	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598001425	catalytic loop [active]
700598001426	iron binding site [ion binding]; other site
700598001427	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
700598001428	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
700598001429	XdhC Rossmann domain; Region: XdhC_C; pfam13478
700598001430	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
700598001431	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
700598001432	Ligand binding site; other site
700598001433	metal-binding site
700598001434	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
700598001435	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598001436	FeS/SAM binding site; other site
700598001437	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
700598001438	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
700598001439	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
700598001440	dimer interface [polypeptide binding]; other site
700598001441	putative functional site; other site
700598001442	putative MPT binding site; other site
700598001443	Ubiquitin-like proteins; Region: UBQ; cl00155
700598001444	charged pocket; other site
700598001445	hydrophobic patch; other site
700598001446	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
700598001447	MoaE homodimer interface [polypeptide binding]; other site
700598001448	MoaD interaction [polypeptide binding]; other site
700598001449	active site residues [active]
700598001450	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
700598001451	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
700598001452	trimer interface [polypeptide binding]; other site
700598001453	dimer interface [polypeptide binding]; other site
700598001454	putative active site [active]
700598001455	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
700598001456	MPT binding site; other site
700598001457	trimer interface [polypeptide binding]; other site
700598001458	Predicted integral membrane protein [Function unknown]; Region: COG5637
700598001459	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
700598001460	putative hydrophobic ligand binding site [chemical binding]; other site
700598001461	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598001462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598001463	active site
700598001464	phosphorylation site [posttranslational modification]
700598001465	intermolecular recognition site; other site
700598001466	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700598001467	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598001468	DNA-binding site [nucleotide binding]; DNA binding site
700598001469	FCD domain; Region: FCD; pfam07729
700598001470	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598001471	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001472	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598001473	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598001474	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598001475	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598001476	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700598001477	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
700598001478	inhibitor site; inhibition site
700598001479	active site
700598001480	dimer interface [polypeptide binding]; other site
700598001481	catalytic residue [active]
700598001482	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
700598001483	catalytic site [active]
700598001484	BNR repeat-like domain; Region: BNR_2; pfam13088
700598001485	Asp-box motif; other site
700598001486	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700598001487	Class I aldolases; Region: Aldolase_Class_I; cl17187
700598001488	catalytic residue [active]
700598001489	cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548
700598001490	Kelch motif; Region: Kelch_5; pfam13854
700598001491	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
700598001492	Na binding site [ion binding]; other site
700598001493	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
700598001494	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
700598001495	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
700598001496	homodimer interface [polypeptide binding]; other site
700598001497	metal binding site [ion binding]; metal-binding site
700598001498	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
700598001499	homodimer interface [polypeptide binding]; other site
700598001500	active site
700598001501	putative chemical substrate binding site [chemical binding]; other site
700598001502	metal binding site [ion binding]; metal-binding site
700598001503	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
700598001504	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
700598001505	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598001506	dimer interface [polypeptide binding]; other site
700598001507	phosphorylation site [posttranslational modification]
700598001508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598001509	ATP binding site [chemical binding]; other site
700598001510	Mg2+ binding site [ion binding]; other site
700598001511	G-X-G motif; other site
700598001512	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
700598001513	hypothetical protein; Provisional; Region: PRK08609
700598001514	metal binding triad [ion binding]; metal-binding site
700598001515	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
700598001516	active site
700598001517	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
700598001518	four helix bundle protein; Region: TIGR02436
700598001519	pyruvate carboxylase; Reviewed; Region: PRK12999
700598001520	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700598001521	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700598001522	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
700598001523	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
700598001524	active site
700598001525	catalytic residues [active]
700598001526	metal binding site [ion binding]; metal-binding site
700598001527	homodimer binding site [polypeptide binding]; other site
700598001528	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
700598001529	carboxyltransferase (CT) interaction site; other site
700598001530	biotinylation site [posttranslational modification]; other site
700598001531	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
700598001532	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
700598001533	GH3 auxin-responsive promoter; Region: GH3; pfam03321
700598001534	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
700598001535	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
700598001536	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
700598001537	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
700598001538	RIP metalloprotease RseP; Region: TIGR00054
700598001539	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
700598001540	active site
700598001541	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
700598001542	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700598001543	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
700598001544	putative substrate binding region [chemical binding]; other site
700598001545	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
700598001546	active site
700598001547	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
700598001548	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
700598001549	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598001550	FtsX-like permease family; Region: FtsX; pfam02687
700598001551	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598001552	FtsX-like permease family; Region: FtsX; pfam02687
700598001553	Part of AAA domain; Region: AAA_19; pfam13245
700598001554	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700598001555	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
700598001556	AAA domain; Region: AAA_12; pfam13087
700598001557	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
700598001558	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
700598001559	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598001560	S-adenosylmethionine binding site [chemical binding]; other site
700598001561	short chain dehydrogenase; Provisional; Region: PRK06197
700598001562	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
700598001563	putative NAD(P) binding site [chemical binding]; other site
700598001564	active site
700598001565	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598001566	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598001567	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598001568	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
700598001569	active site
700598001570	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598001571	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598001572	active site
700598001573	catalytic tetrad [active]
700598001574	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598001575	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598001576	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700598001577	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
700598001578	FMN binding site [chemical binding]; other site
700598001579	active site
700598001580	substrate binding site [chemical binding]; other site
700598001581	catalytic residue [active]
700598001582	Cupin domain; Region: Cupin_2; cl17218
700598001583	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598001584	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598001585	catalytic residues [active]
700598001586	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598001587	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598001588	ligand binding site [chemical binding]; other site
700598001589	flexible hinge region; other site
700598001590	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
700598001591	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
700598001592	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700598001593	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598001594	substrate binding pocket [chemical binding]; other site
700598001595	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598001596	Pirin-related protein [General function prediction only]; Region: COG1741
700598001597	Pirin; Region: Pirin; pfam02678
700598001598	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
700598001599	IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603
700598001600	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
700598001601	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
700598001602	putative NAD(P) binding site [chemical binding]; other site
700598001603	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598001604	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598001605	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598001606	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598001607	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
700598001608	NADP binding site [chemical binding]; other site
700598001609	putative substrate binding site [chemical binding]; other site
700598001610	active site
700598001611	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
700598001612	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
700598001613	Metal-binding active site; metal-binding site
700598001614	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
700598001615	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598001616	Histidine kinase; Region: His_kinase; pfam06580
700598001617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598001618	ATP binding site [chemical binding]; other site
700598001619	Mg2+ binding site [ion binding]; other site
700598001620	G-X-G motif; other site
700598001621	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598001622	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598001623	active site
700598001624	phosphorylation site [posttranslational modification]
700598001625	intermolecular recognition site; other site
700598001626	dimerization interface [polypeptide binding]; other site
700598001627	LytTr DNA-binding domain; Region: LytTR; smart00850
700598001628	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
700598001629	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001630	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
700598001631	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700598001632	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598001633	S-adenosylmethionine binding site [chemical binding]; other site
700598001634	Uncharacterized conserved protein [Function unknown]; Region: COG3391
700598001635	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700598001636	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
700598001637	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598001638	putative DNA binding site [nucleotide binding]; other site
700598001639	putative Zn2+ binding site [ion binding]; other site
700598001640	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
700598001641	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
700598001642	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
700598001643	putative hydrophobic ligand binding site [chemical binding]; other site
700598001644	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598001645	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598001646	active site
700598001647	metal binding site [ion binding]; metal-binding site
700598001648	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263
700598001649	Heme binding sites [chemical binding]; other site
700598001650	Histidine kinase; Region: His_kinase; pfam06580
700598001651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598001652	Response regulator receiver domain; Region: Response_reg; pfam00072
700598001653	active site
700598001654	phosphorylation site [posttranslational modification]
700598001655	intermolecular recognition site; other site
700598001656	dimerization interface [polypeptide binding]; other site
700598001657	LytTr DNA-binding domain; Region: LytTR; smart00850
700598001658	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598001659	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598001660	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
700598001661	Glyco_18 domain; Region: Glyco_18; smart00636
700598001662	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
700598001663	active site
700598001664	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
700598001665	PKC phosphorylation site [posttranslational modification]; other site
700598001666	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001667	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
700598001668	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598001669	putative metal binding site [ion binding]; other site
700598001670	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598001671	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598001672	ligand binding site [chemical binding]; other site
700598001673	flexible hinge region; other site
700598001674	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
700598001675	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598001676	Sm and related proteins; Region: Sm_like; cl00259
700598001677	Protein of unknown function (DUF805); Region: DUF805; pfam05656
700598001678	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598001679	Coenzyme A binding pocket [chemical binding]; other site
700598001680	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598001681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598001682	ATP binding site [chemical binding]; other site
700598001683	Mg2+ binding site [ion binding]; other site
700598001684	G-X-G motif; other site
700598001685	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598001686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598001687	active site
700598001688	phosphorylation site [posttranslational modification]
700598001689	intermolecular recognition site; other site
700598001690	dimerization interface [polypeptide binding]; other site
700598001691	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598001692	DNA binding residues [nucleotide binding]
700598001693	dimerization interface [polypeptide binding]; other site
700598001694	Predicted esterase [General function prediction only]; Region: COG0400
700598001695	putative hydrolase; Provisional; Region: PRK11460
700598001696	K+ potassium transporter; Region: K_trans; pfam02705
700598001697	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598001698	RibD C-terminal domain; Region: RibD_C; cl17279
700598001699	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
700598001700	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598001701	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598001702	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598001703	LytTr DNA-binding domain; Region: LytTR; smart00850
700598001704	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
700598001705	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
700598001706	active site
700598001707	catalytic residues [active]
700598001708	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
700598001709	PKC phosphorylation site [posttranslational modification]; other site
700598001710	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
700598001711	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
700598001712	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
700598001713	PKC phosphorylation site [posttranslational modification]; other site
700598001714	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598001715	Cytochrome c; Region: Cytochrom_C; cl11414
700598001716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598001717	TPR motif; other site
700598001718	TPR repeat; Region: TPR_11; pfam13414
700598001719	binding surface
700598001720	TROVE domain; Region: TROVE; pfam05731
700598001721	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598001722	Coenzyme A binding pocket [chemical binding]; other site
700598001723	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700598001724	MarR family; Region: MarR_2; pfam12802
700598001725	He_PIG associated, NEW1 domain of bacterial glycohydrolase; Region: He_PIG_assoc; pfam10632
700598001726	Putative Ig domain; Region: He_PIG; pfam05345
700598001727	alpha-galactosidase; Region: PLN02229
700598001728	alpha-galactosidase; Region: PLN02808; cl17638
700598001729	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
700598001730	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598001731	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
700598001732	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001733	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
700598001734	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
700598001735	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
700598001736	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
700598001737	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
700598001738	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598001739	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598001740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598001741	active site
700598001742	phosphorylation site [posttranslational modification]
700598001743	intermolecular recognition site; other site
700598001744	dimerization interface [polypeptide binding]; other site
700598001745	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598001746	DNA binding residues [nucleotide binding]
700598001747	dimerization interface [polypeptide binding]; other site
700598001748	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598001749	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598001750	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598001751	binding surface
700598001752	TPR motif; other site
700598001753	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598001754	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598001755	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598001756	Histidine kinase; Region: HisKA_3; pfam07730
700598001757	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598001758	ATP binding site [chemical binding]; other site
700598001759	Mg2+ binding site [ion binding]; other site
700598001760	G-X-G motif; other site
700598001761	Tetratricopeptide repeat; Region: TPR_16; pfam13432
700598001762	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700598001763	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598001764	ATP binding site [chemical binding]; other site
700598001765	Walker A motif; other site
700598001766	Walker B motif; other site
700598001767	arginine finger; other site
700598001768	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598001769	binding surface
700598001770	TPR motif; other site
700598001771	TPR repeat; Region: TPR_11; pfam13414
700598001772	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598001773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598001774	TPR motif; other site
700598001775	binding surface
700598001776	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598001777	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598001778	ligand binding site [chemical binding]; other site
700598001779	flexible hinge region; other site
700598001780	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598001781	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598001782	active site
700598001783	catalytic tetrad [active]
700598001784	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
700598001785	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
700598001786	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
700598001787	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
700598001788	Fibronectin type 3 domain; Region: FN3; smart00060
700598001789	trehalose synthase; Region: treS_nterm; TIGR02456
700598001790	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
700598001791	active site
700598001792	catalytic site [active]
700598001793	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
700598001794	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
700598001795	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
700598001796	substrate binding site [chemical binding]; other site
700598001797	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
700598001798	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
700598001799	putative molybdopterin cofactor binding site [chemical binding]; other site
700598001800	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
700598001801	putative molybdopterin cofactor binding site; other site
700598001802	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
700598001803	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
700598001804	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
700598001805	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
700598001806	active site
700598001807	catalytic residues [active]
700598001808	L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160
700598001809	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
700598001810	hexamer (dimer of trimers) interface [polypeptide binding]; other site
700598001811	trimer interface [polypeptide binding]; other site
700598001812	substrate binding site [chemical binding]; other site
700598001813	Mn binding site [ion binding]; other site
700598001814	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
700598001815	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
700598001816	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
700598001817	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598001818	putative ADP-binding pocket [chemical binding]; other site
700598001819	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598001820	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598001821	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598001822	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598001823	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598001824	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598001825	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598001826	DNA binding residues [nucleotide binding]
700598001827	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700598001828	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
700598001829	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700598001830	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
700598001831	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598001832	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598001833	active site
700598001834	metal binding site [ion binding]; metal-binding site
700598001835	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
700598001836	active site
700598001837	catalytic triad [active]
700598001838	oxyanion hole [active]
700598001839	glycerol kinase; Provisional; Region: glpK; PRK00047
700598001840	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
700598001841	N- and C-terminal domain interface [polypeptide binding]; other site
700598001842	active site
700598001843	MgATP binding site [chemical binding]; other site
700598001844	catalytic site [active]
700598001845	metal binding site [ion binding]; metal-binding site
700598001846	glycerol binding site [chemical binding]; other site
700598001847	homotetramer interface [polypeptide binding]; other site
700598001848	homodimer interface [polypeptide binding]; other site
700598001849	FBP binding site [chemical binding]; other site
700598001850	protein IIAGlc interface [polypeptide binding]; other site
700598001851	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
700598001852	amphipathic channel; other site
700598001853	Asn-Pro-Ala signature motifs; other site
700598001854	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
700598001855	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
700598001856	active site
700598001857	catalytic site [active]
700598001858	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
700598001859	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
700598001860	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
700598001861	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
700598001862	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
700598001863	NADP binding site [chemical binding]; other site
700598001864	homodimer interface [polypeptide binding]; other site
700598001865	active site
700598001866	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
700598001867	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
700598001868	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
700598001869	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
700598001870	substrate binding site [chemical binding]; other site
700598001871	active site
700598001872	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598001873	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598001874	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598001875	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001876	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598001877	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598001878	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598001879	Fasciclin domain; Region: Fasciclin; pfam02469
700598001880	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts; Region: FAS1; smart00554
700598001881	Fasciclin domain; Region: Fasciclin; cl02663
700598001882	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598001883	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598001884	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001885	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598001886	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598001887	Fasciclin domain; Region: Fasciclin; cl02663
700598001888	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598001889	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001890	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598001891	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598001892	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598001893	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598001894	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598001895	SusD family; Region: SusD; pfam07980
700598001896	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
700598001897	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
700598001898	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
700598001899	Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_1; cd11747
700598001900	homodimer interface [polypeptide binding]; other site
700598001901	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700598001902	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598001903	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001904	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
700598001905	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598001906	putative catalytic residue [active]
700598001907	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598001908	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598001909	catalytic residues [active]
700598001910	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
700598001911	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
700598001912	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700598001913	classical (c) SDRs; Region: SDR_c; cd05233
700598001914	NAD(P) binding site [chemical binding]; other site
700598001915	active site
700598001916	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
700598001917	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
700598001918	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
700598001919	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598001920	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598001921	DNA binding site [nucleotide binding]
700598001922	domain linker motif; other site
700598001923	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598001924	dimerization interface [polypeptide binding]; other site
700598001925	ligand binding site [chemical binding]; other site
700598001926	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700598001927	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598001928	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700598001929	mannonate dehydratase; Provisional; Region: PRK03906
700598001930	mannonate dehydratase; Region: uxuA; TIGR00695
700598001931	Sulfatase; Region: Sulfatase; pfam00884
700598001932	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598001933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598001934	active site
700598001935	phosphorylation site [posttranslational modification]
700598001936	intermolecular recognition site; other site
700598001937	dimerization interface [polypeptide binding]; other site
700598001938	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598001939	DNA binding site [nucleotide binding]
700598001940	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598001941	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598001942	dimer interface [polypeptide binding]; other site
700598001943	phosphorylation site [posttranslational modification]
700598001944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598001945	ATP binding site [chemical binding]; other site
700598001946	Mg2+ binding site [ion binding]; other site
700598001947	G-X-G motif; other site
700598001948	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001949	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598001950	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598001951	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
700598001952	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700598001953	active site
700598001954	Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971
700598001955	Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089
700598001956	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972
700598001957	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
700598001958	metal binding site [ion binding]; metal-binding site
700598001959	active site
700598001960	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
700598001961	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
700598001962	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
700598001963	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598001964	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598001965	SusD family; Region: SusD; pfam07980
700598001966	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598001967	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598001968	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598001969	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598001970	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
700598001971	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598001972	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598001973	ligand binding site [chemical binding]; other site
700598001974	flexible hinge region; other site
700598001975	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
700598001976	active site
700598001977	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
700598001978	Beta/Gamma crystallin; Region: Crystall; cl02528
700598001979	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001980	Glyco_18 domain; Region: Glyco_18; smart00636
700598001981	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
700598001982	active site
700598001983	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598001984	sugar binding site [chemical binding]; other site
700598001985	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
700598001986	Ca binding site [ion binding]; other site
700598001987	ligand binding site I [chemical binding]; other site
700598001988	homodimer interface [polypeptide binding]; other site
700598001989	ligand binding site II [chemical binding]; other site
700598001990	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598001991	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
700598001992	active site
700598001993	catalytic residues [active]
700598001994	Beta/Gamma crystallin; Region: Crystall; cl02528
700598001995	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
700598001996	Ca binding site [ion binding]; other site
700598001997	ligand binding site I [chemical binding]; other site
700598001998	homodimer interface [polypeptide binding]; other site
700598001999	ligand binding site II [chemical binding]; other site
700598002000	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598002001	Glyco_18 domain; Region: Glyco_18; smart00636
700598002002	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
700598002003	active site
700598002004	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
700598002005	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
700598002006	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
700598002007	Glyco_18 domain; Region: Glyco_18; smart00636
700598002008	putative active site [active]
700598002009	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
700598002010	aromatic chitin/cellulose binding site residues [chemical binding]; other site
700598002011	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
700598002012	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598002013	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598002014	FtsX-like permease family; Region: FtsX; pfam02687
700598002015	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598002016	FtsX-like permease family; Region: FtsX; pfam02687
700598002017	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598002018	putative substrate translocation pore; other site
700598002019	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598002020	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598002021	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598002022	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598002023	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
700598002024	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598002025	Protein export membrane protein; Region: SecD_SecF; cl14618
700598002026	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598002027	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598002028	putative hydrolase; Provisional; Region: PRK11460
700598002029	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
700598002030	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
700598002031	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598002032	Zn binding site [ion binding]; other site
700598002033	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
700598002034	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598002035	Zn binding site [ion binding]; other site
700598002036	Uncharacterized conserved protein [Function unknown]; Region: COG2353
700598002037	Uncharacterized conserved protein [Function unknown]; Region: COG2353
700598002038	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598002039	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598002040	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598002041	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
700598002042	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
700598002043	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
700598002044	FeoA domain; Region: FeoA; pfam04023
700598002045	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
700598002046	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
700598002047	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
700598002048	iron-sulfur cluster [ion binding]; other site
700598002049	[2Fe-2S] cluster binding site [ion binding]; other site
700598002050	RibD C-terminal domain; Region: RibD_C; cl17279
700598002051	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
700598002052	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
700598002053	metal ion-dependent adhesion site (MIDAS); other site
700598002054	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700598002055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598002056	Walker A motif; other site
700598002057	ATP binding site [chemical binding]; other site
700598002058	Walker B motif; other site
700598002059	arginine finger; other site
700598002060	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
700598002061	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
700598002062	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
700598002063	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
700598002064	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598002065	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
700598002066	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
700598002067	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
700598002068	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
700598002069	putative hydrophobic ligand binding site [chemical binding]; other site
700598002070	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
700598002071	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598002072	Protein of unknown function, DUF488; Region: DUF488; pfam04343
700598002073	Methyltransferase domain; Region: Methyltransf_12; pfam08242
700598002074	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
700598002075	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
700598002076	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
700598002077	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
700598002078	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
700598002079	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
700598002080	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
700598002081	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
700598002082	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
700598002083	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598002084	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598002085	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
700598002086	GH3 auxin-responsive promoter; Region: GH3; pfam03321
700598002087	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
700598002088	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700598002089	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
700598002090	Uncharacterized conserved protein [Function unknown]; Region: COG2898
700598002091	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
700598002092	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598002093	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
700598002094	FtsX-like permease family; Region: FtsX; pfam02687
700598002095	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598002096	FtsX-like permease family; Region: FtsX; pfam02687
700598002097	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598002098	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598002099	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598002100	DNA binding residues [nucleotide binding]
700598002101	FecR protein; Region: FecR; pfam04773
700598002102	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598002103	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598002104	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598002105	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598002106	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598002107	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598002108	SusD family; Region: SusD; pfam07980
700598002109	SusE outer membrane protein; Region: SusE; pfam14292
700598002110	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
700598002111	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598002112	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598002113	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598002114	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598002115	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598002116	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598002117	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598002118	Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
700598002119	active site
700598002120	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598002121	glycosyl hydrolase 64 family; Region: GH64-like; cd09214
700598002122	substrate binding pocket [chemical binding]; other site
700598002123	catalytic residues [active]
700598002124	Beta/Gamma crystallin; Region: Crystall; cl02528
700598002125	Beta/Gamma crystallin; Region: Crystall; cl02528
700598002126	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
700598002127	Ca binding site [ion binding]; other site
700598002128	ligand binding site I [chemical binding]; other site
700598002129	homodimer interface [polypeptide binding]; other site
700598002130	ligand binding site II [chemical binding]; other site
700598002131	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598002132	Immunoglobulin domain; Region: Ig; cl11960
700598002133	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598002134	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
700598002135	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700598002136	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700598002137	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
700598002138	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598002139	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598002140	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598002141	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598002142	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
700598002143	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598002144	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
700598002145	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598002146	catalytic residues [active]
700598002147	Domain of unknown function DUF302; Region: DUF302; pfam03625
700598002148	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
700598002149	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598002150	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598002151	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598002152	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598002153	Protein export membrane protein; Region: SecD_SecF; cl14618
700598002154	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
700598002155	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598002156	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598002157	ligand binding site [chemical binding]; other site
700598002158	flexible hinge region; other site
700598002159	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700598002160	putative switch regulator; other site
700598002161	non-specific DNA interactions [nucleotide binding]; other site
700598002162	DNA binding site [nucleotide binding]
700598002163	sequence specific DNA binding site [nucleotide binding]; other site
700598002164	putative cAMP binding site [chemical binding]; other site
700598002165	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700598002166	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598002167	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700598002168	active site residue [active]
700598002169	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700598002170	active site residue [active]
700598002171	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700598002172	active site residue [active]
700598002173	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598002174	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
700598002175	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598002176	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598002177	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
700598002178	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
700598002179	putative active site [active]
700598002180	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598002181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598002182	Walker A/P-loop; other site
700598002183	ATP binding site [chemical binding]; other site
700598002184	Q-loop/lid; other site
700598002185	ABC transporter signature motif; other site
700598002186	Walker B; other site
700598002187	D-loop; other site
700598002188	H-loop/switch region; other site
700598002189	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
700598002190	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598002191	FeS/SAM binding site; other site
700598002192	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
700598002193	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
700598002194	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598002195	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598002196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598002197	Response regulator receiver domain; Region: Response_reg; pfam00072
700598002198	active site
700598002199	phosphorylation site [posttranslational modification]
700598002200	intermolecular recognition site; other site
700598002201	dimerization interface [polypeptide binding]; other site
700598002202	Histidine kinase; Region: His_kinase; pfam06580
700598002203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598002204	ATP binding site [chemical binding]; other site
700598002205	Mg2+ binding site [ion binding]; other site
700598002206	G-X-G motif; other site
700598002207	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598002208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598002209	active site
700598002210	phosphorylation site [posttranslational modification]
700598002211	intermolecular recognition site; other site
700598002212	dimerization interface [polypeptide binding]; other site
700598002213	LytTr DNA-binding domain; Region: LytTR; smart00850
700598002214	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
700598002215	putative FMN binding site [chemical binding]; other site
700598002216	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598002217	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598002218	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
700598002219	classical (c) SDRs; Region: SDR_c; cd05233
700598002220	NAD(P) binding site [chemical binding]; other site
700598002221	active site
700598002222	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598002223	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
700598002224	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700598002225	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598002226	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
700598002227	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
700598002228	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
700598002229	putative sugar binding sites [chemical binding]; other site
700598002230	Q-X-W motif; other site
700598002231	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598002232	Domain of unknown function (DUF4304); Region: DUF4304; pfam14137
700598002233	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
700598002234	active site
700598002235	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598002236	DoxX-like family; Region: DoxX_3; pfam13781
700598002237	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
700598002238	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598002239	Methyltransferase domain; Region: Methyltransf_11; pfam08241
700598002240	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598002241	short chain dehydrogenase; Provisional; Region: PRK08263
700598002242	NADP binding site [chemical binding]; other site
700598002243	active site
700598002244	steroid binding site; other site
700598002245	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598002246	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598002247	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598002248	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
700598002249	Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
700598002250	active site
700598002251	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598002252	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
700598002253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598002254	Walker A/P-loop; other site
700598002255	ATP binding site [chemical binding]; other site
700598002256	Q-loop/lid; other site
700598002257	ABC transporter signature motif; other site
700598002258	Walker B; other site
700598002259	D-loop; other site
700598002260	H-loop/switch region; other site
700598002261	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700598002262	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598002263	Walker A/P-loop; other site
700598002264	ATP binding site [chemical binding]; other site
700598002265	Q-loop/lid; other site
700598002266	ABC transporter signature motif; other site
700598002267	Walker B; other site
700598002268	D-loop; other site
700598002269	H-loop/switch region; other site
700598002270	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
700598002271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598002272	ATP binding site [chemical binding]; other site
700598002273	Mg2+ binding site [ion binding]; other site
700598002274	G-X-G motif; other site
700598002275	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
700598002276	ATP binding site [chemical binding]; other site
700598002277	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
700598002278	active site
700598002279	putative metal-binding site [ion binding]; other site
700598002280	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
700598002281	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
700598002282	Protein of unknown function; Region: DUF3658; pfam12395
700598002283	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
700598002284	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
700598002285	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
700598002286	CAP-like domain; other site
700598002287	active site
700598002288	primary dimer interface [polypeptide binding]; other site
700598002289	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
700598002290	SmpB-tmRNA interface; other site
700598002291	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
700598002292	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
700598002293	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
700598002294	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
700598002295	putative Iron-sulfur protein interface [polypeptide binding]; other site
700598002296	proximal heme binding site [chemical binding]; other site
700598002297	distal heme binding site [chemical binding]; other site
700598002298	putative dimer interface [polypeptide binding]; other site
700598002299	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
700598002300	L-aspartate oxidase; Provisional; Region: PRK06175
700598002301	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
700598002302	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
700598002303	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
700598002304	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
700598002305	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598002306	Walker A/P-loop; other site
700598002307	ATP binding site [chemical binding]; other site
700598002308	Q-loop/lid; other site
700598002309	ABC transporter signature motif; other site
700598002310	Walker B; other site
700598002311	D-loop; other site
700598002312	H-loop/switch region; other site
700598002313	ABC transporter; Region: ABC_tran_2; pfam12848
700598002314	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700598002315	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598002316	S-adenosylmethionine binding site [chemical binding]; other site
700598002317	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
700598002318	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
700598002319	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
700598002320	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
700598002321	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
700598002322	active site
700598002323	Riboflavin kinase; Region: Flavokinase; pfam01687
700598002324	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
700598002325	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
700598002326	dimerization interface [polypeptide binding]; other site
700598002327	ATP binding site [chemical binding]; other site
700598002328	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700598002329	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700598002330	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700598002331	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
700598002332	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
700598002333	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
700598002334	active site
700598002335	metal binding site [ion binding]; metal-binding site
700598002336	Gram-negative bacterial tonB protein; Region: TonB; cl10048
700598002337	Penicillinase repressor; Region: Pencillinase_R; pfam03965
700598002338	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
700598002339	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
700598002340	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598002341	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
700598002342	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598002343	DNA binding residues [nucleotide binding]
700598002344	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
700598002345	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
700598002346	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598002347	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700598002348	Dihydroneopterin aldolase; Region: FolB; pfam02152
700598002349	active site
700598002350	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598002351	TPR motif; other site
700598002352	binding surface
700598002353	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
700598002354	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
700598002355	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
700598002356	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
700598002357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598002358	S-adenosylmethionine binding site [chemical binding]; other site
700598002359	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
700598002360	AAA domain; Region: AAA_26; pfam13500
700598002361	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
700598002362	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
700598002363	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
700598002364	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
700598002365	ribonuclease R; Region: RNase_R; TIGR02063
700598002366	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
700598002367	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
700598002368	RNB domain; Region: RNB; pfam00773
700598002369	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
700598002370	RNA binding site [nucleotide binding]; other site
700598002371	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
700598002372	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
700598002373	substrate binding pocket [chemical binding]; other site
700598002374	chain length determination region; other site
700598002375	substrate-Mg2+ binding site; other site
700598002376	catalytic residues [active]
700598002377	aspartate-rich region 1; other site
700598002378	active site lid residues [active]
700598002379	aspartate-rich region 2; other site
700598002380	amino acid transporter; Region: 2A0306; TIGR00909
700598002381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
700598002382	Smr domain; Region: Smr; pfam01713
700598002383	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
700598002384	Cytochrome c; Region: Cytochrom_C; cl11414
700598002385	YceI-like domain; Region: YceI; pfam04264
700598002386	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598002387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598002388	S-adenosylmethionine binding site [chemical binding]; other site
700598002389	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
700598002390	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
700598002391	Na binding site [ion binding]; other site
700598002392	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
700598002393	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700598002394	inhibitor site; inhibition site
700598002395	active site
700598002396	dimer interface [polypeptide binding]; other site
700598002397	catalytic residue [active]
700598002398	SnoaL-like domain; Region: SnoaL_2; pfam12680
700598002399	glycine dehydrogenase; Provisional; Region: PRK05367
700598002400	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
700598002401	tetramer interface [polypeptide binding]; other site
700598002402	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598002403	catalytic residue [active]
700598002404	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
700598002405	tetramer interface [polypeptide binding]; other site
700598002406	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598002407	catalytic residue [active]
700598002408	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
700598002409	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
700598002410	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
700598002411	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
700598002412	Flagellin N-methylase; Region: FliB; pfam03692
700598002413	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
700598002414	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
700598002415	TrkA-C domain; Region: TrkA_C; pfam02080
700598002416	TrkA-C domain; Region: TrkA_C; pfam02080
700598002417	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
700598002418	cysteine synthase B; Region: cysM; TIGR01138
700598002419	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
700598002420	dimer interface [polypeptide binding]; other site
700598002421	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598002422	catalytic residue [active]
700598002423	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598002424	putative substrate translocation pore; other site
700598002425	H+ Antiporter protein; Region: 2A0121; TIGR00900
700598002426	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
700598002427	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
700598002428	Substrate-binding site [chemical binding]; other site
700598002429	Substrate specificity [chemical binding]; other site
700598002430	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
700598002431	catalytic center binding site [active]
700598002432	ATP binding site [chemical binding]; other site
700598002433	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
700598002434	tandem repeat interface [polypeptide binding]; other site
700598002435	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
700598002436	oligomer interface [polypeptide binding]; other site
700598002437	active site residues [active]
700598002438	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
700598002439	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
700598002440	tandem repeat interface [polypeptide binding]; other site
700598002441	oligomer interface [polypeptide binding]; other site
700598002442	active site residues [active]
700598002443	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
700598002444	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
700598002445	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598002446	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
700598002447	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598002448	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598002449	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598002450	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598002451	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598002452	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598002453	Uncharacterized conserved protein [Function unknown]; Region: COG4095
700598002454	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
700598002455	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598002456	Coenzyme A binding pocket [chemical binding]; other site
700598002457	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700598002458	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
700598002459	inhibitor-cofactor binding pocket; inhibition site
700598002460	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598002461	catalytic residue [active]
700598002462	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598002463	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598002464	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598002465	DNA binding residues [nucleotide binding]
700598002466	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598002467	Uncharacterized conserved protein [Function unknown]; Region: COG5276
700598002468	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
700598002469	4Fe-4S binding domain; Region: Fer4; pfam00037
700598002470	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
700598002471	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598002472	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598002473	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700598002474	L-fuculokinase; Region: fuculo_kin_coli; TIGR02628
700598002475	nucleotide binding site [chemical binding]; other site
700598002476	xylose isomerase; Provisional; Region: PRK05474
700598002477	xylose isomerase; Region: xylose_isom_A; TIGR02630
700598002478	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
700598002479	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
700598002480	Na binding site [ion binding]; other site
700598002481	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
700598002482	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598002483	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598002484	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
700598002485	Clp amino terminal domain; Region: Clp_N; pfam02861
700598002486	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598002487	Walker A motif; other site
700598002488	ATP binding site [chemical binding]; other site
700598002489	Walker B motif; other site
700598002490	arginine finger; other site
700598002491	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598002492	Walker A motif; other site
700598002493	ATP binding site [chemical binding]; other site
700598002494	Walker B motif; other site
700598002495	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
700598002496	Thioredoxin; Region: Thioredoxin_4; cl17273
700598002497	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
700598002498	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
700598002499	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
700598002500	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598002501	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
700598002502	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598002503	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
700598002504	active site
700598002505	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
700598002506	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
700598002507	domain interfaces; other site
700598002508	active site
700598002509	6-phosphofructokinase; Provisional; Region: PRK03202
700598002510	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
700598002511	active site
700598002512	ADP/pyrophosphate binding site [chemical binding]; other site
700598002513	dimerization interface [polypeptide binding]; other site
700598002514	allosteric effector site; other site
700598002515	fructose-1,6-bisphosphate binding site; other site
700598002516	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
700598002517	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
700598002518	NADP binding site [chemical binding]; other site
700598002519	active site
700598002520	putative substrate binding site [chemical binding]; other site
700598002521	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
700598002522	Amidinotransferase; Region: Amidinotransf; pfam02274
700598002523	Amidinotransferase; Region: Amidinotransf; cl12043
700598002524	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700598002525	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
700598002526	FAD binding site [chemical binding]; other site
700598002527	homotetramer interface [polypeptide binding]; other site
700598002528	substrate binding pocket [chemical binding]; other site
700598002529	catalytic base [active]
700598002530	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
700598002531	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700598002532	catalytic residue [active]
700598002533	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
700598002534	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598002535	active site
700598002536	HIGH motif; other site
700598002537	nucleotide binding site [chemical binding]; other site
700598002538	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
700598002539	KMSKS motif; other site
700598002540	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
700598002541	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
700598002542	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
700598002543	metal binding site [ion binding]; metal-binding site
700598002544	putative dimer interface [polypeptide binding]; other site
700598002545	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
700598002546	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
700598002547	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
700598002548	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598002549	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598002550	active site
700598002551	phosphorylation site [posttranslational modification]
700598002552	intermolecular recognition site; other site
700598002553	dimerization interface [polypeptide binding]; other site
700598002554	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598002555	DNA binding site [nucleotide binding]
700598002556	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598002557	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598002558	dimer interface [polypeptide binding]; other site
700598002559	phosphorylation site [posttranslational modification]
700598002560	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598002561	ATP binding site [chemical binding]; other site
700598002562	Mg2+ binding site [ion binding]; other site
700598002563	G-X-G motif; other site
700598002564	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
700598002565	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
700598002566	active site
700598002567	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700598002568	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
700598002569	NodB motif; other site
700598002570	putative active site [active]
700598002571	putative catalytic site [active]
700598002572	putative Zn binding site [ion binding]; other site
700598002573	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
700598002574	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
700598002575	DXD motif; other site
700598002576	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598002577	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
700598002578	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
700598002579	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
700598002580	Protein export membrane protein; Region: SecD_SecF; pfam02355
700598002581	aspartate aminotransferase; Provisional; Region: PRK05764
700598002582	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598002583	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598002584	homodimer interface [polypeptide binding]; other site
700598002585	catalytic residue [active]
700598002586	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
700598002587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
700598002588	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598002589	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
700598002590	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
700598002591	CoA-binding site [chemical binding]; other site
700598002592	ATP-binding [chemical binding]; other site
700598002593	Preprotein translocase subunit; Region: YajC; pfam02699
700598002594	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
700598002595	transcription antitermination factor NusB; Region: nusB; TIGR01951
700598002596	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
700598002597	oligomerisation interface [polypeptide binding]; other site
700598002598	mobile loop; other site
700598002599	roof hairpin; other site
700598002600	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
700598002601	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
700598002602	ring oligomerisation interface [polypeptide binding]; other site
700598002603	ATP/Mg binding site [chemical binding]; other site
700598002604	stacking interactions; other site
700598002605	hinge regions; other site
700598002606	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
700598002607	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
700598002608	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
700598002609	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598002610	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
700598002611	active site
700598002612	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
700598002613	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
700598002614	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
700598002615	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
700598002616	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
700598002617	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
700598002618	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598002619	FeS/SAM binding site; other site
700598002620	nucleoside transporter; Region: 2A0110; TIGR00889
700598002621	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
700598002622	catalytic residues [active]
700598002623	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
700598002624	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
700598002625	active site
700598002626	PHP Thumb interface [polypeptide binding]; other site
700598002627	metal binding site [ion binding]; metal-binding site
700598002628	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
700598002629	generic binding surface II; other site
700598002630	generic binding surface I; other site
700598002631	NlpC/P60 family; Region: NLPC_P60; pfam00877
700598002632	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598002633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598002634	ATP binding site [chemical binding]; other site
700598002635	Mg2+ binding site [ion binding]; other site
700598002636	G-X-G motif; other site
700598002637	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
700598002638	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
700598002639	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
700598002640	Zn binding site [ion binding]; other site
700598002641	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
700598002642	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
700598002643	methionine sulfoxide reductase A; Provisional; Region: PRK14054
700598002644	MutS domain III; Region: MutS_III; pfam05192
700598002645	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598002646	Walker A/P-loop; other site
700598002647	ATP binding site [chemical binding]; other site
700598002648	Q-loop/lid; other site
700598002649	ABC transporter signature motif; other site
700598002650	Walker B; other site
700598002651	D-loop; other site
700598002652	H-loop/switch region; other site
700598002653	FOG: CBS domain [General function prediction only]; Region: COG0517
700598002654	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
700598002655	glutamate dehydrogenase 2; Provisional; Region: PTZ00324
700598002656	phosphoenolpyruvate synthase; Validated; Region: PRK06241
700598002657	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
700598002658	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
700598002659	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
700598002660	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
700598002661	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
700598002662	active site
700598002663	catalytic residues [active]
700598002664	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
700598002665	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
700598002666	substrate binding pocket [chemical binding]; other site
700598002667	chain length determination region; other site
700598002668	substrate-Mg2+ binding site; other site
700598002669	catalytic residues [active]
700598002670	aspartate-rich region 1; other site
700598002671	active site lid residues [active]
700598002672	aspartate-rich region 2; other site
700598002673	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
700598002674	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598002675	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
700598002676	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
700598002677	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
700598002678	Phage Tail Collar Domain; Region: Collar; pfam07484
700598002679	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
700598002680	Phage Tail Collar Domain; Region: Collar; pfam07484
700598002681	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
700598002682	Phage Tail Collar Domain; Region: Collar; pfam07484
700598002683	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598002684	Histidine kinase; Region: HisKA_3; pfam07730
700598002685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598002686	ATP binding site [chemical binding]; other site
700598002687	Mg2+ binding site [ion binding]; other site
700598002688	G-X-G motif; other site
700598002689	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598002690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598002691	active site
700598002692	phosphorylation site [posttranslational modification]
700598002693	intermolecular recognition site; other site
700598002694	dimerization interface [polypeptide binding]; other site
700598002695	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598002696	DNA binding residues [nucleotide binding]
700598002697	dimerization interface [polypeptide binding]; other site
700598002698	TIR domain; Region: TIR_2; pfam13676
700598002699	HEAT repeats; Region: HEAT_2; pfam13646
700598002700	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
700598002701	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
700598002702	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598002703	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598002704	ligand binding site [chemical binding]; other site
700598002705	flexible hinge region; other site
700598002706	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598002707	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598002708	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598002709	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
700598002710	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598002711	NAD(P) binding site [chemical binding]; other site
700598002712	active site
700598002713	Helix-turn-helix domain; Region: HTH_17; pfam12728
700598002714	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
700598002715	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
700598002716	adenylate kinase; Reviewed; Region: adk; PRK00279
700598002717	AMP-binding site [chemical binding]; other site
700598002718	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
700598002719	Protein of unknown function DUF262; Region: DUF262; pfam03235
700598002720	Protein of unknown function DUF262; Region: DUF262; pfam03235
700598002721	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700598002722	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
700598002723	active site
700598002724	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
700598002725	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
700598002726	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
700598002727	putative active site [active]
700598002728	putative metal-binding site [ion binding]; other site
700598002729	Helix-turn-helix domain; Region: HTH_17; pfam12728
700598002730	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
700598002731	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
700598002732	non-specific DNA binding site [nucleotide binding]; other site
700598002733	salt bridge; other site
700598002734	sequence-specific DNA binding site [nucleotide binding]; other site
700598002735	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
700598002736	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
700598002737	active site
700598002738	metal binding site [ion binding]; metal-binding site
700598002739	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
700598002740	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
700598002741	ORF6N domain; Region: ORF6N; pfam10543
700598002742	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700598002743	active site
700598002744	DNA binding site [nucleotide binding]
700598002745	Int/Topo IB signature motif; other site
700598002746	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
700598002747	Int/Topo IB signature motif; other site
700598002748	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
700598002749	active site
700598002750	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598002751	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598002752	active site
700598002753	catalytic tetrad [active]
700598002754	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
700598002755	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700598002756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700598002757	LysR substrate binding domain; Region: LysR_substrate; pfam03466
700598002758	dimerization interface [polypeptide binding]; other site
700598002759	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
700598002760	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
700598002761	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
700598002762	FMN binding site [chemical binding]; other site
700598002763	active site
700598002764	catalytic residues [active]
700598002765	substrate binding site [chemical binding]; other site
700598002766	GAF domain; Region: GAF_2; pfam13185
700598002767	Phosphoesterase family; Region: Phosphoesterase; pfam04185
700598002768	Phosphoesterase family; Region: Phosphoesterase; pfam04185
700598002769	Domain of unknown function (DUF756); Region: DUF756; pfam05506
700598002770	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598002771	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
700598002772	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598002773	MG2 domain; Region: A2M_N; pfam01835
700598002774	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
700598002775	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598002776	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598002777	Alpha-2-macroglobulin family; Region: A2M; pfam00207
700598002778	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
700598002779	surface patch; other site
700598002780	thioester region; other site
700598002781	specificity defining residues; other site
700598002782	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598002783	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
700598002784	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598002785	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598002786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598002787	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
700598002788	putative hydrophobic ligand binding site [chemical binding]; other site
700598002789	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700598002790	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
700598002791	YARHG domain; Region: YARHG; pfam13308
700598002792	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598002793	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598002794	putative active site [active]
700598002795	heme pocket [chemical binding]; other site
700598002796	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598002797	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598002798	putative active site [active]
700598002799	heme pocket [chemical binding]; other site
700598002800	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598002801	putative active site [active]
700598002802	heme pocket [chemical binding]; other site
700598002803	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598002804	Histidine kinase; Region: HisKA_3; pfam07730
700598002805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598002806	ATP binding site [chemical binding]; other site
700598002807	Mg2+ binding site [ion binding]; other site
700598002808	G-X-G motif; other site
700598002809	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598002810	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598002811	active site
700598002812	phosphorylation site [posttranslational modification]
700598002813	intermolecular recognition site; other site
700598002814	dimerization interface [polypeptide binding]; other site
700598002815	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598002816	DNA binding residues [nucleotide binding]
700598002817	dimerization interface [polypeptide binding]; other site
700598002818	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
700598002819	putative active site [active]
700598002820	Response regulator receiver domain; Region: Response_reg; pfam00072
700598002821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598002822	active site
700598002823	phosphorylation site [posttranslational modification]
700598002824	intermolecular recognition site; other site
700598002825	dimerization interface [polypeptide binding]; other site
700598002826	Peptidase family M48; Region: Peptidase_M48; cl12018
700598002827	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
700598002828	AAA domain; Region: AAA_11; pfam13086
700598002829	Part of AAA domain; Region: AAA_19; pfam13245
700598002830	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
700598002831	AAA domain; Region: AAA_12; pfam13087
700598002832	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
700598002833	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598002834	PAS domain; Region: PAS_9; pfam13426
700598002835	putative active site [active]
700598002836	heme pocket [chemical binding]; other site
700598002837	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598002838	Histidine kinase; Region: HisKA_3; pfam07730
700598002839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598002840	ATP binding site [chemical binding]; other site
700598002841	Mg2+ binding site [ion binding]; other site
700598002842	G-X-G motif; other site
700598002843	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
700598002844	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598002845	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
700598002846	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
700598002847	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
700598002848	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
700598002849	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598002850	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
700598002851	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
700598002852	homotetramer interface [polypeptide binding]; other site
700598002853	ligand binding site [chemical binding]; other site
700598002854	catalytic site [active]
700598002855	NAD binding site [chemical binding]; other site
700598002856	Rrf2 family protein; Region: rrf2_super; TIGR00738
700598002857	Transcriptional regulator; Region: Rrf2; pfam02082
700598002858	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598002859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598002860	active site
700598002861	phosphorylation site [posttranslational modification]
700598002862	intermolecular recognition site; other site
700598002863	dimerization interface [polypeptide binding]; other site
700598002864	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598002865	DNA binding residues [nucleotide binding]
700598002866	dimerization interface [polypeptide binding]; other site
700598002867	dihydrodipicolinate reductase; Provisional; Region: PRK00048
700598002868	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
700598002869	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
700598002870	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
700598002871	ParB-like nuclease domain; Region: ParBc; pfam02195
700598002872	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
700598002873	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
700598002874	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700598002875	P-loop; other site
700598002876	Magnesium ion binding site [ion binding]; other site
700598002877	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700598002878	Magnesium ion binding site [ion binding]; other site
700598002879	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700598002880	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
700598002881	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
700598002882	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700598002883	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
700598002884	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598002885	putative active site [active]
700598002886	putative metal binding site [ion binding]; other site
700598002887	CHASE3 domain; Region: CHASE3; cl05000
700598002888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598002889	PAS domain; Region: PAS_9; pfam13426
700598002890	putative active site [active]
700598002891	heme pocket [chemical binding]; other site
700598002892	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598002893	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598002894	dimer interface [polypeptide binding]; other site
700598002895	phosphorylation site [posttranslational modification]
700598002896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598002897	ATP binding site [chemical binding]; other site
700598002898	Mg2+ binding site [ion binding]; other site
700598002899	G-X-G motif; other site
700598002900	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598002901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598002902	active site
700598002903	phosphorylation site [posttranslational modification]
700598002904	intermolecular recognition site; other site
700598002905	dimerization interface [polypeptide binding]; other site
700598002906	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598002907	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
700598002908	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
700598002909	active site
700598002910	dimer interface [polypeptide binding]; other site
700598002911	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
700598002912	dimer interface [polypeptide binding]; other site
700598002913	active site
700598002914	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
700598002915	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
700598002916	tetramer interface [polypeptide binding]; other site
700598002917	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598002918	catalytic residue [active]
700598002919	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598002920	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598002921	dimer interface [polypeptide binding]; other site
700598002922	phosphorylation site [posttranslational modification]
700598002923	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598002924	ATP binding site [chemical binding]; other site
700598002925	Mg2+ binding site [ion binding]; other site
700598002926	G-X-G motif; other site
700598002927	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
700598002928	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598002929	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598002930	S-adenosylmethionine binding site [chemical binding]; other site
700598002931	peptide chain release factor 2; Validated; Region: prfB; PRK00578
700598002932	This domain is found in peptide chain release factors; Region: PCRF; smart00937
700598002933	RF-1 domain; Region: RF-1; pfam00472
700598002934	NIMA-related protein kinase; Provisional; Region: PTZ00267
700598002935	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
700598002936	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
700598002937	Glutamate binding site [chemical binding]; other site
700598002938	NAD binding site [chemical binding]; other site
700598002939	catalytic residues [active]
700598002940	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
700598002941	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700598002942	active site
700598002943	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
700598002944	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
700598002945	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
700598002946	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
700598002947	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
700598002948	active site
700598002949	(T/H)XGH motif; other site
700598002950	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700598002951	CoenzymeA binding site [chemical binding]; other site
700598002952	subunit interaction site [polypeptide binding]; other site
700598002953	PHB binding site; other site
700598002954	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
700598002955	active site
700598002956	Ap6A binding site [chemical binding]; other site
700598002957	nudix motif; other site
700598002958	metal binding site [ion binding]; metal-binding site
700598002959	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700598002960	active site
700598002961	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
700598002962	metal-binding site [ion binding]
700598002963	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
700598002964	WbqC-like protein family; Region: WbqC; pfam08889
700598002965	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
700598002966	Penicillinase repressor; Region: Pencillinase_R; pfam03965
700598002967	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
700598002968	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
700598002969	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491
700598002970	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
700598002971	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
700598002972	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
700598002973	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
700598002974	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598002975	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598002976	catalytic residues [active]
700598002977	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
700598002978	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
700598002979	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598002980	putative catalytic residue [active]
700598002981	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
700598002982	YceG-like family; Region: YceG; pfam02618
700598002983	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
700598002984	dimerization interface [polypeptide binding]; other site
700598002985	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
700598002986	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
700598002987	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598002988	Walker A motif; other site
700598002989	ATP binding site [chemical binding]; other site
700598002990	Walker B motif; other site
700598002991	arginine finger; other site
700598002992	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
700598002993	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
700598002994	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
700598002995	TRAM domain; Region: TRAM; pfam01938
700598002996	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
700598002997	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
700598002998	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598002999	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598003000	S-adenosylmethionine binding site [chemical binding]; other site
700598003001	polyphosphate kinase; Provisional; Region: PRK05443
700598003002	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
700598003003	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
700598003004	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
700598003005	domain interface [polypeptide binding]; other site
700598003006	active site
700598003007	catalytic site [active]
700598003008	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
700598003009	putative active site [active]
700598003010	catalytic site [active]
700598003011	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
700598003012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598003013	putative substrate translocation pore; other site
700598003014	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
700598003015	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700598003016	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700598003017	Walker A/P-loop; other site
700598003018	ATP binding site [chemical binding]; other site
700598003019	Q-loop/lid; other site
700598003020	ABC transporter signature motif; other site
700598003021	Walker B; other site
700598003022	D-loop; other site
700598003023	H-loop/switch region; other site
700598003024	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
700598003025	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003026	FtsX-like permease family; Region: FtsX; pfam02687
700598003027	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003028	FtsX-like permease family; Region: FtsX; pfam02687
700598003029	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003030	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598003031	FtsX-like permease family; Region: FtsX; pfam02687
700598003032	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598003033	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003034	FtsX-like permease family; Region: FtsX; pfam02687
700598003035	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003036	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598003037	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003038	FtsX-like permease family; Region: FtsX; pfam02687
700598003039	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003040	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
700598003041	FtsX-like permease family; Region: FtsX; pfam02687
700598003042	FtsX-like permease family; Region: FtsX; pfam02687
700598003043	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700598003044	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700598003045	Walker A/P-loop; other site
700598003046	ATP binding site [chemical binding]; other site
700598003047	Q-loop/lid; other site
700598003048	ABC transporter signature motif; other site
700598003049	Walker B; other site
700598003050	D-loop; other site
700598003051	H-loop/switch region; other site
700598003052	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598003053	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598003054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598003055	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
700598003056	active site
700598003057	phosphorylation site [posttranslational modification]
700598003058	intermolecular recognition site; other site
700598003059	dimerization interface [polypeptide binding]; other site
700598003060	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598003061	Walker A motif; other site
700598003062	ATP binding site [chemical binding]; other site
700598003063	Walker B motif; other site
700598003064	arginine finger; other site
700598003065	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
700598003066	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598003067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598003068	ATP binding site [chemical binding]; other site
700598003069	Mg2+ binding site [ion binding]; other site
700598003070	G-X-G motif; other site
700598003071	GTP-binding protein YchF; Reviewed; Region: PRK09601
700598003072	YchF GTPase; Region: YchF; cd01900
700598003073	G1 box; other site
700598003074	GTP/Mg2+ binding site [chemical binding]; other site
700598003075	Switch I region; other site
700598003076	G2 box; other site
700598003077	Switch II region; other site
700598003078	G3 box; other site
700598003079	G4 box; other site
700598003080	G5 box; other site
700598003081	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
700598003082	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
700598003083	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
700598003084	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598003085	SusD family; Region: SusD; pfam07980
700598003086	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003087	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003088	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598003089	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
700598003090	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598003091	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700598003092	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700598003093	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700598003094	TraB family; Region: TraB; pfam01963
700598003095	OstA-like protein; Region: OstA_2; pfam13100
700598003096	OstA-like protein; Region: OstA; cl00844
700598003097	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
700598003098	mce related protein; Region: MCE; pfam02470
700598003099	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
700598003100	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
700598003101	active site
700598003102	metal binding site [ion binding]; metal-binding site
700598003103	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
700598003104	active site
700598003105	metal binding site [ion binding]; metal-binding site
700598003106	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
700598003107	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
700598003108	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700598003109	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
700598003110	putative acyl-acceptor binding pocket; other site
700598003111	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
700598003112	ligand binding site [chemical binding]; other site
700598003113	active site
700598003114	UGI interface [polypeptide binding]; other site
700598003115	catalytic site [active]
700598003116	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598003117	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598003118	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598003119	DNA binding residues [nucleotide binding]
700598003120	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598003121	FecR protein; Region: FecR; pfam04773
700598003122	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598003123	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003124	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003125	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598003126	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598003127	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598003128	SusD family; Region: SusD; pfam07980
700598003129	Family description; Region: VCBS; pfam13517
700598003130	Family description; Region: VCBS; pfam13517
700598003131	Family description; Region: VCBS; pfam13517
700598003132	Family description; Region: VCBS; pfam13517
700598003133	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
700598003134	Family description; Region: VCBS; pfam13517
700598003135	Family description; Region: VCBS; pfam13517
700598003136	Family description; Region: VCBS; pfam13517
700598003137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598003138	Response regulator receiver domain; Region: Response_reg; pfam00072
700598003139	active site
700598003140	phosphorylation site [posttranslational modification]
700598003141	intermolecular recognition site; other site
700598003142	dimerization interface [polypeptide binding]; other site
700598003143	BON domain; Region: BON; pfam04972
700598003144	BON domain; Region: BON; pfam04972
700598003145	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
700598003146	Domain of unknown function DUF20; Region: UPF0118; pfam01594
700598003147	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
700598003148	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598003149	NAD(P) binding site [chemical binding]; other site
700598003150	active site
700598003151	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
700598003152	Flavin Reductases; Region: FlaRed; cl00801
700598003153	TspO/MBR family; Region: TspO_MBR; pfam03073
700598003154	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
700598003155	putative hydrophobic ligand binding site [chemical binding]; other site
700598003156	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
700598003157	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700598003158	DNA binding residues [nucleotide binding]
700598003159	B12 binding domain; Region: B12-binding_2; pfam02607
700598003160	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
700598003161	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598003162	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598003163	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598003164	helicase 45; Provisional; Region: PTZ00424
700598003165	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
700598003166	ATP binding site [chemical binding]; other site
700598003167	Mg++ binding site [ion binding]; other site
700598003168	motif III; other site
700598003169	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598003170	nucleotide binding region [chemical binding]; other site
700598003171	ATP-binding site [chemical binding]; other site
700598003172	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
700598003173	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700598003174	Di-iron ligands [ion binding]; other site
700598003175	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
700598003176	TspO/MBR family; Region: TspO_MBR; pfam03073
700598003177	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
700598003178	putative hydrophobic ligand binding site [chemical binding]; other site
700598003179	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
700598003180	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
700598003181	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700598003182	DNA binding residues [nucleotide binding]
700598003183	B12 binding domain; Region: B12-binding_2; pfam02607
700598003184	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
700598003185	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
700598003186	dimer interface [polypeptide binding]; other site
700598003187	PYR/PP interface [polypeptide binding]; other site
700598003188	TPP binding site [chemical binding]; other site
700598003189	substrate binding site [chemical binding]; other site
700598003190	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
700598003191	Domain of unknown function; Region: EKR; pfam10371
700598003192	4Fe-4S binding domain; Region: Fer4_6; pfam12837
700598003193	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
700598003194	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
700598003195	TPP-binding site [chemical binding]; other site
700598003196	dimer interface [polypeptide binding]; other site
700598003197	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
700598003198	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700598003199	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700598003200	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
700598003201	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
700598003202	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
700598003203	nickel binding site [ion binding]; other site
700598003204	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
700598003205	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
700598003206	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
700598003207	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
700598003208	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
700598003209	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
700598003210	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
700598003211	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
700598003212	G1 box; other site
700598003213	GTP/Mg2+ binding site [chemical binding]; other site
700598003214	G2 box; other site
700598003215	Switch I region; other site
700598003216	Switch II region; other site
700598003217	G4 box; other site
700598003218	G5 box; other site
700598003219	Acylphosphatase; Region: Acylphosphatase; pfam00708
700598003220	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
700598003221	HypF finger; Region: zf-HYPF; pfam07503
700598003222	HypF finger; Region: zf-HYPF; pfam07503
700598003223	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
700598003224	HupF/HypC family; Region: HupF_HypC; pfam01455
700598003225	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
700598003226	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
700598003227	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
700598003228	dimerization interface [polypeptide binding]; other site
700598003229	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
700598003230	ATP binding site [chemical binding]; other site
700598003231	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
700598003232	DinB superfamily; Region: DinB_2; pfam12867
700598003233	Patatin-like phospholipase; Region: Patatin; pfam01734
700598003234	active site
700598003235	nucleophile elbow; other site
700598003236	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
700598003237	Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831
700598003238	active site
700598003239	catalytic triad [active]
700598003240	oxyanion hole [active]
700598003241	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598003242	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598003243	SusD family; Region: SusD; pfam07980
700598003244	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003245	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003246	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598003247	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598003248	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577
700598003249	putative active site [active]
700598003250	catalytic site [active]
700598003251	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598003252	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598003253	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
700598003254	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598003255	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
700598003256	active site
700598003257	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
700598003258	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
700598003259	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003260	GtrA-like protein; Region: GtrA; pfam04138
700598003261	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
700598003262	tetramer interfaces [polypeptide binding]; other site
700598003263	binuclear metal-binding site [ion binding]; other site
700598003264	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
700598003265	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
700598003266	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598003267	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598003268	NAD(P) binding site [chemical binding]; other site
700598003269	active site
700598003270	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
700598003271	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
700598003272	substrate-cofactor binding pocket; other site
700598003273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598003274	catalytic residue [active]
700598003275	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598003276	DoxX-like family; Region: DoxX_2; pfam13564
700598003277	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
700598003278	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598003279	dimer interface [polypeptide binding]; other site
700598003280	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
700598003281	conserved cys residue [active]
700598003282	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598003283	potential frameshift: common BLAST hit: gi|255034368|ref|YP_003084989.1| histidine kinase
700598003284	Response regulator receiver domain; Region: Response_reg; pfam00072
700598003285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598003286	active site
700598003287	phosphorylation site [posttranslational modification]
700598003288	intermolecular recognition site; other site
700598003289	dimerization interface [polypeptide binding]; other site
700598003290	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700598003291	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598003292	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598003293	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598003294	Two component regulator propeller; Region: Reg_prop; pfam07494
700598003295	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598003296	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598003297	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598003298	dimer interface [polypeptide binding]; other site
700598003299	phosphorylation site [posttranslational modification]
700598003300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598003301	ATP binding site [chemical binding]; other site
700598003302	Mg2+ binding site [ion binding]; other site
700598003303	G-X-G motif; other site
700598003304	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003305	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003306	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598003307	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598003308	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598003309	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598003310	SusD family; Region: SusD; pfam07980
700598003311	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
700598003312	active site
700598003313	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
700598003314	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
700598003315	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
700598003316	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
700598003317	Walker A/P-loop; other site
700598003318	ATP binding site [chemical binding]; other site
700598003319	Q-loop/lid; other site
700598003320	ABC transporter signature motif; other site
700598003321	Walker B; other site
700598003322	D-loop; other site
700598003323	H-loop/switch region; other site
700598003324	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
700598003325	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598003326	Walker A/P-loop; other site
700598003327	ATP binding site [chemical binding]; other site
700598003328	Q-loop/lid; other site
700598003329	ABC transporter signature motif; other site
700598003330	Walker B; other site
700598003331	D-loop; other site
700598003332	H-loop/switch region; other site
700598003333	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
700598003334	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
700598003335	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
700598003336	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
700598003337	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598003338	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
700598003339	FeS/SAM binding site; other site
700598003340	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
700598003341	ribonuclease Y; Region: RNase_Y; TIGR03319
700598003342	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700598003343	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
700598003344	TM-ABC transporter signature motif; other site
700598003345	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
700598003346	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
700598003347	TM-ABC transporter signature motif; other site
700598003348	AAA domain; Region: AAA_22; pfam13401
700598003349	AAA domain; Region: AAA_14; pfam13173
700598003350	TIR domain; Region: TIR_2; pfam13676
700598003351	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
700598003352	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598003353	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598003354	DNA binding residues [nucleotide binding]
700598003355	Putative serine esterase (DUF676); Region: DUF676; pfam05057
700598003356	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598003357	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
700598003358	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700598003359	IPT/TIG domain; Region: TIG; pfam01833
700598003360	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598003361	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598003362	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700598003363	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
700598003364	FMN binding site [chemical binding]; other site
700598003365	active site
700598003366	substrate binding site [chemical binding]; other site
700598003367	catalytic residue [active]
700598003368	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
700598003369	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
700598003370	putative NAD(P) binding site [chemical binding]; other site
700598003371	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
700598003372	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700598003373	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598003374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598003375	Walker A/P-loop; other site
700598003376	ATP binding site [chemical binding]; other site
700598003377	Q-loop/lid; other site
700598003378	ABC transporter signature motif; other site
700598003379	Walker B; other site
700598003380	D-loop; other site
700598003381	H-loop/switch region; other site
700598003382	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700598003383	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598003384	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598003385	Walker A/P-loop; other site
700598003386	ATP binding site [chemical binding]; other site
700598003387	Q-loop/lid; other site
700598003388	ABC transporter signature motif; other site
700598003389	Walker B; other site
700598003390	D-loop; other site
700598003391	H-loop/switch region; other site
700598003392	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003393	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598003394	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598003395	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598003396	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598003397	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598003398	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700598003399	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003400	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003401	FtsX-like permease family; Region: FtsX; pfam02687
700598003402	Pectic acid lyase; Region: Pec_lyase; pfam09492
700598003403	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
700598003404	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
700598003405	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003406	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003407	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598003408	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598003409	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598003410	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598003411	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598003412	SusD family; Region: SusD; pfam07980
700598003413	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598003414	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
700598003415	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
700598003416	Pectate lyase; Region: Pec_lyase_C; cl01593
700598003417	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598003418	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598003419	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598003420	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598003421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598003422	dimer interface [polypeptide binding]; other site
700598003423	phosphorylation site [posttranslational modification]
700598003424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598003425	ATP binding site [chemical binding]; other site
700598003426	Mg2+ binding site [ion binding]; other site
700598003427	G-X-G motif; other site
700598003428	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598003429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598003430	active site
700598003431	phosphorylation site [posttranslational modification]
700598003432	intermolecular recognition site; other site
700598003433	dimerization interface [polypeptide binding]; other site
700598003434	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598003435	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598003436	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003437	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003438	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598003439	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598003440	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598003441	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598003442	Pectate lyase; Region: Pec_lyase_C; cl01593
700598003443	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
700598003444	Interdomain contacts; other site
700598003445	Cytokine receptor motif; other site
700598003446	autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601
700598003447	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
700598003448	Interdomain contacts; other site
700598003449	Cytokine receptor motif; other site
700598003450	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598003451	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
700598003452	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700598003453	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
700598003454	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598003455	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
700598003456	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
700598003457	putative active site [active]
700598003458	catalytic triad [active]
700598003459	putative dimer interface [polypeptide binding]; other site
700598003460	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
700598003461	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598003462	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598003463	SusD family; Region: SusD; pfam07980
700598003464	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003465	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003466	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
700598003467	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598003468	SusD family; Region: SusD; pfam07980
700598003469	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003470	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003471	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598003472	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598003473	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
700598003474	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
700598003475	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
700598003476	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
700598003477	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598003478	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598003479	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598003480	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598003481	sugar binding site [chemical binding]; other site
700598003482	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700598003483	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
700598003484	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
700598003485	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
700598003486	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
700598003487	active site
700598003488	catalytic triad [active]
700598003489	oxyanion hole [active]
700598003490	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598003491	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598003492	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
700598003493	Sel1-like repeats; Region: SEL1; smart00671
700598003494	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598003495	ligand binding site [chemical binding]; other site
700598003496	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577
700598003497	putative active site [active]
700598003498	catalytic site [active]
700598003499	Uncharacterized conserved protein [Function unknown]; Region: COG1479
700598003500	Protein of unknown function DUF262; Region: DUF262; pfam03235
700598003501	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
700598003502	Short C-terminal domain; Region: SHOCT; pfam09851
700598003503	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
700598003504	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
700598003505	Beta-propeller repeat; Region: SBBP; pfam06739
700598003506	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598003507	Beta-propeller repeat; Region: SBBP; pfam06739
700598003508	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598003509	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003510	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003511	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598003512	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598003513	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598003514	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598003515	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700598003516	Sulfatase; Region: Sulfatase; pfam00884
700598003517	Sulfatase; Region: Sulfatase; cl17466
700598003518	Lipase maturation factor; Region: LMF1; pfam06762
700598003519	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
700598003520	dimer interface [polypeptide binding]; other site
700598003521	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
700598003522	dimer interface [polypeptide binding]; other site
700598003523	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598003524	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598003525	catalytic residues [active]
700598003526	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598003527	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598003528	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598003529	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003530	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003531	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598003532	FecR protein; Region: FecR; pfam04773
700598003533	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598003534	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598003535	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598003536	DNA binding residues [nucleotide binding]
700598003537	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
700598003538	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
700598003539	active site
700598003540	DNA polymerase IV; Validated; Region: PRK02406
700598003541	DNA binding site [nucleotide binding]
700598003542	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
700598003543	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598003544	Coenzyme A binding pocket [chemical binding]; other site
700598003545	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
700598003546	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
700598003547	potential catalytic triad [active]
700598003548	conserved cys residue [active]
700598003549	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
700598003550	translocation protein TolB; Provisional; Region: tolB; PRK03629
700598003551	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598003552	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598003553	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598003554	Histidine kinase; Region: HisKA_3; pfam07730
700598003555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598003556	ATP binding site [chemical binding]; other site
700598003557	Mg2+ binding site [ion binding]; other site
700598003558	G-X-G motif; other site
700598003559	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598003560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598003561	active site
700598003562	phosphorylation site [posttranslational modification]
700598003563	intermolecular recognition site; other site
700598003564	dimerization interface [polypeptide binding]; other site
700598003565	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598003566	DNA binding residues [nucleotide binding]
700598003567	dimerization interface [polypeptide binding]; other site
700598003568	Uncharacterized conserved protein [Function unknown]; Region: COG2454
700598003569	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
700598003570	RHS Repeat; Region: RHS_repeat; pfam05593
700598003571	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
700598003572	RHS Repeat; Region: RHS_repeat; pfam05593
700598003573	RHS Repeat; Region: RHS_repeat; pfam05593
700598003574	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598003575	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598003576	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598003577	binding surface
700598003578	TPR motif; other site
700598003579	TPR repeat; Region: TPR_11; pfam13414
700598003580	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598003581	TPR repeat; Region: TPR_11; pfam13414
700598003582	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598003583	binding surface
700598003584	TPR motif; other site
700598003585	TPR repeat; Region: TPR_11; pfam13414
700598003586	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598003587	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598003588	TPR motif; other site
700598003589	binding surface
700598003590	TPR repeat; Region: TPR_11; pfam13414
700598003591	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598003592	binding surface
700598003593	Tetratricopeptide repeat; Region: TPR_16; pfam13432
700598003594	TPR motif; other site
700598003595	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598003596	binding surface
700598003597	TPR motif; other site
700598003598	CHAT domain; Region: CHAT; cl17868
700598003599	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598003600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598003601	active site
700598003602	phosphorylation site [posttranslational modification]
700598003603	intermolecular recognition site; other site
700598003604	dimerization interface [polypeptide binding]; other site
700598003605	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598003606	DNA binding residues [nucleotide binding]
700598003607	dimerization interface [polypeptide binding]; other site
700598003608	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
700598003609	nudix motif; other site
700598003610	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598003611	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598003612	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
700598003613	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598003614	DNA-binding site [nucleotide binding]; DNA binding site
700598003615	FCD domain; Region: FCD; pfam07729
700598003616	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598003617	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598003618	putative substrate translocation pore; other site
700598003619	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700598003620	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
700598003621	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598003622	catalytic residue [active]
700598003623	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
700598003624	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
700598003625	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
700598003626	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
700598003627	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
700598003628	dimer interface [polypeptide binding]; other site
700598003629	active site
700598003630	heme binding site [chemical binding]; other site
700598003631	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
700598003632	chaperone protein DnaJ; Provisional; Region: PRK14299
700598003633	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
700598003634	HSP70 interaction site [polypeptide binding]; other site
700598003635	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
700598003636	substrate binding site [polypeptide binding]; other site
700598003637	dimer interface [polypeptide binding]; other site
700598003638	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
700598003639	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598003640	catalytic residues [active]
700598003641	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
700598003642	DNA-binding site [nucleotide binding]; DNA binding site
700598003643	RNA-binding motif; other site
700598003644	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
700598003645	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
700598003646	ATP binding site [chemical binding]; other site
700598003647	putative Mg++ binding site [ion binding]; other site
700598003648	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598003649	nucleotide binding region [chemical binding]; other site
700598003650	ATP-binding site [chemical binding]; other site
700598003651	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
700598003652	RNA binding site [nucleotide binding]; other site
700598003653	Protein of unknown function, DUF481; Region: DUF481; cl01213
700598003654	Thioredoxin; Region: Thioredoxin_4; pfam13462
700598003655	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
700598003656	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
700598003657	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598003658	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
700598003659	dimer interface [polypeptide binding]; other site
700598003660	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598003661	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598003662	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598003663	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598003664	short chain dehydrogenase; Provisional; Region: PRK08263
700598003665	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598003666	NADP binding site [chemical binding]; other site
700598003667	active site
700598003668	steroid binding site; other site
700598003669	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598003670	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598003671	Active site serine [active]
700598003672	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598003673	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598003674	Uncharacterized conserved protein [Function unknown]; Region: COG1262
700598003675	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
700598003676	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
700598003677	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
700598003678	putative Cl- selectivity filter; other site
700598003679	putative pore gating glutamate residue; other site
700598003680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598003681	NADH(P)-binding; Region: NAD_binding_10; pfam13460
700598003682	NAD(P) binding site [chemical binding]; other site
700598003683	active site
700598003684	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598003685	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598003686	dimerization interface [polypeptide binding]; other site
700598003687	putative Zn2+ binding site [ion binding]; other site
700598003688	putative DNA binding site [nucleotide binding]; other site
700598003689	DoxX; Region: DoxX; cl17842
700598003690	Restriction endonuclease; Region: Mrr_cat; pfam04471
700598003691	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
700598003692	Interdomain contacts; other site
700598003693	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
700598003694	Cytokine receptor motif; other site
700598003695	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
700598003696	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700598003697	DNA binding residues [nucleotide binding]
700598003698	dimer interface [polypeptide binding]; other site
700598003699	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
700598003700	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003701	FtsX-like permease family; Region: FtsX; pfam02687
700598003702	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598003703	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003704	FtsX-like permease family; Region: FtsX; pfam02687
700598003705	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
700598003706	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816
700598003707	dimer interface [polypeptide binding]; other site
700598003708	active site
700598003709	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
700598003710	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
700598003711	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
700598003712	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
700598003713	active site
700598003714	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
700598003715	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598003716	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598003717	ligand binding site [chemical binding]; other site
700598003718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598003719	NAD(P) binding site [chemical binding]; other site
700598003720	active site
700598003721	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598003722	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598003723	FecR protein; Region: FecR; pfam04773
700598003724	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003725	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598003726	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598003727	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
700598003728	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598003729	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598003730	Outer membrane efflux protein; Region: OEP; pfam02321
700598003731	Outer membrane efflux protein; Region: OEP; pfam02321
700598003732	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
700598003733	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598003734	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598003735	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
700598003736	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598003737	DNA-binding site [nucleotide binding]; DNA binding site
700598003738	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
700598003739	putative dimerization interface [polypeptide binding]; other site
700598003740	putative ligand binding site [chemical binding]; other site
700598003741	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598003742	putative transporter; Provisional; Region: PRK10484
700598003743	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
700598003744	Na binding site [ion binding]; other site
700598003745	alpha-galactosidase; Region: PLN02229
700598003746	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598003747	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003748	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598003749	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598003750	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598003751	SusD family; Region: SusD; pfam07980
700598003752	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700598003753	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598003754	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700598003755	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
700598003756	Melibiase; Region: Melibiase; pfam02065
700598003757	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
700598003758	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
700598003759	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
700598003760	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
700598003761	putative active site [active]
700598003762	metal binding site [ion binding]; metal-binding site
700598003763	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700598003764	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
700598003765	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
700598003766	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598003767	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598003768	ligand binding site [chemical binding]; other site
700598003769	flexible hinge region; other site
700598003770	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003771	FtsX-like permease family; Region: FtsX; pfam02687
700598003772	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003773	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598003774	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598003775	ligand binding site [chemical binding]; other site
700598003776	flexible hinge region; other site
700598003777	Histidine kinase; Region: His_kinase; pfam06580
700598003778	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598003779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598003780	active site
700598003781	phosphorylation site [posttranslational modification]
700598003782	intermolecular recognition site; other site
700598003783	dimerization interface [polypeptide binding]; other site
700598003784	LytTr DNA-binding domain; Region: LytTR; smart00850
700598003785	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
700598003786	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
700598003787	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
700598003788	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
700598003789	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
700598003790	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
700598003791	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598003792	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598003793	ligand binding site [chemical binding]; other site
700598003794	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
700598003795	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598003796	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598003797	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
700598003798	heme-binding site [chemical binding]; other site
700598003799	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598003800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598003801	active site
700598003802	phosphorylation site [posttranslational modification]
700598003803	intermolecular recognition site; other site
700598003804	dimerization interface [polypeptide binding]; other site
700598003805	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598003806	DNA binding residues [nucleotide binding]
700598003807	dimerization interface [polypeptide binding]; other site
700598003808	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598003809	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598003810	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598003811	binding surface
700598003812	TPR motif; other site
700598003813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598003814	Histidine kinase; Region: HisKA_3; pfam07730
700598003815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598003816	ATP binding site [chemical binding]; other site
700598003817	Mg2+ binding site [ion binding]; other site
700598003818	G-X-G motif; other site
700598003819	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598003820	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598003821	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598003822	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598003823	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
700598003824	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598003825	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
700598003826	TPR repeat; Region: TPR_11; pfam13414
700598003827	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598003828	TPR repeat; Region: TPR_11; pfam13414
700598003829	binding surface
700598003830	TPR motif; other site
700598003831	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598003832	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598003833	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598003834	ligand binding site [chemical binding]; other site
700598003835	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
700598003836	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
700598003837	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598003838	Cucumber mosaic virus 1a protein C terminal; Region: CMV_1a_C; pfam12503
700598003839	Family of unknown function (DUF695); Region: DUF695; pfam05117
700598003840	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598003841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598003842	active site
700598003843	phosphorylation site [posttranslational modification]
700598003844	intermolecular recognition site; other site
700598003845	dimerization interface [polypeptide binding]; other site
700598003846	LytTr DNA-binding domain; Region: LytTR; smart00850
700598003847	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598003848	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
700598003849	Histidine kinase; Region: HisKA_2; pfam07568
700598003850	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
700598003851	ATP binding site [chemical binding]; other site
700598003852	Mg2+ binding site [ion binding]; other site
700598003853	G-X-G motif; other site
700598003854	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598003855	putative DNA binding site [nucleotide binding]; other site
700598003856	dimerization interface [polypeptide binding]; other site
700598003857	putative Zn2+ binding site [ion binding]; other site
700598003858	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
700598003859	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598003860	putative substrate translocation pore; other site
700598003861	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598003862	active site
700598003863	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598003864	catalytic tetrad [active]
700598003865	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
700598003866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598003867	S-adenosylmethionine binding site [chemical binding]; other site
700598003868	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
700598003869	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
700598003870	DinB superfamily; Region: DinB_2; pfam12867
700598003871	metal-dependent hydrolase; Provisional; Region: PRK13291
700598003872	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
700598003873	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
700598003874	Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483
700598003875	active site
700598003876	catalytic triad [active]
700598003877	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598003878	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598003879	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598003880	ligand binding site [chemical binding]; other site
700598003881	aldehyde dehydrogenase family 7 member; Region: PLN02315
700598003882	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
700598003883	tetrameric interface [polypeptide binding]; other site
700598003884	NAD binding site [chemical binding]; other site
700598003885	catalytic residues [active]
700598003886	agmatinase; Region: agmatinase; TIGR01230
700598003887	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
700598003888	putative active site [active]
700598003889	Mn binding site [ion binding]; other site
700598003890	Pleckstrin homology-like domain; Region: PH-like; cl17171
700598003891	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
700598003892	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
700598003893	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
700598003894	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
700598003895	active site
700598003896	nucleotide binding site [chemical binding]; other site
700598003897	HIGH motif; other site
700598003898	KMSKS motif; other site
700598003899	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
700598003900	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
700598003901	tetramerization interface [polypeptide binding]; other site
700598003902	active site
700598003903	pantoate--beta-alanine ligase; Region: panC; TIGR00018
700598003904	Pantoate-beta-alanine ligase; Region: PanC; cd00560
700598003905	active site
700598003906	ATP-binding site [chemical binding]; other site
700598003907	pantoate-binding site; other site
700598003908	HXXH motif; other site
700598003909	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
700598003910	S-adenosylmethionine synthetase; Validated; Region: PRK05250
700598003911	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
700598003912	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
700598003913	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
700598003914	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
700598003915	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
700598003916	ADP-ribose binding site [chemical binding]; other site
700598003917	dimer interface [polypeptide binding]; other site
700598003918	active site
700598003919	nudix motif; other site
700598003920	metal binding site [ion binding]; metal-binding site
700598003921	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
700598003922	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
700598003923	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
700598003924	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
700598003925	active site
700598003926	catalytic residues [active]
700598003927	metal binding site [ion binding]; metal-binding site
700598003928	GSCFA family; Region: GSCFA; pfam08885
700598003929	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598003930	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598003931	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
700598003932	ligand binding site [chemical binding]; other site
700598003933	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
700598003934	active site
700598003935	dinuclear metal binding site [ion binding]; other site
700598003936	dimerization interface [polypeptide binding]; other site
700598003937	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
700598003938	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
700598003939	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598003940	catalytic residue [active]
700598003941	Cupin domain; Region: Cupin_2; cl17218
700598003942	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
700598003943	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
700598003944	active site
700598003945	RDD family; Region: RDD; pfam06271
700598003946	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003947	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
700598003948	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
700598003949	active site residue [active]
700598003950	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
700598003951	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
700598003952	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
700598003953	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
700598003954	ATP binding site [chemical binding]; other site
700598003955	active site
700598003956	substrate binding site [chemical binding]; other site
700598003957	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598003958	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598003959	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598003960	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003961	FtsX-like permease family; Region: FtsX; pfam02687
700598003962	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598003963	FtsX-like permease family; Region: FtsX; pfam02687
700598003964	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
700598003965	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
700598003966	Walker A/P-loop; other site
700598003967	ATP binding site [chemical binding]; other site
700598003968	Q-loop/lid; other site
700598003969	ABC transporter signature motif; other site
700598003970	Walker B; other site
700598003971	D-loop; other site
700598003972	H-loop/switch region; other site
700598003973	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
700598003974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
700598003975	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
700598003976	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700598003977	membrane-bound complex binding site; other site
700598003978	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598003979	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598003980	ligand binding site [chemical binding]; other site
700598003981	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
700598003982	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
700598003983	Cysteine-rich domain; Region: CCG; pfam02754
700598003984	Cysteine-rich domain; Region: CCG; pfam02754
700598003985	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
700598003986	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
700598003987	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598003988	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598003989	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
700598003990	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
700598003991	dimer interface [polypeptide binding]; other site
700598003992	active site
700598003993	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
700598003994	putative ligand binding site [chemical binding]; other site
700598003995	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598003996	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
700598003997	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
700598003998	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
700598003999	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598004000	FtsX-like permease family; Region: FtsX; pfam02687
700598004001	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
700598004002	active site
700598004003	intersubunit interactions; other site
700598004004	catalytic residue [active]
700598004005	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
700598004006	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
700598004007	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
700598004008	Walker A/P-loop; other site
700598004009	ATP binding site [chemical binding]; other site
700598004010	Q-loop/lid; other site
700598004011	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
700598004012	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
700598004013	ABC transporter signature motif; other site
700598004014	Walker B; other site
700598004015	D-loop; other site
700598004016	H-loop/switch region; other site
700598004017	Protein of unknown function, DUF486; Region: DUF486; cl01236
700598004018	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
700598004019	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
700598004020	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
700598004021	DNA Topoisomerase IV; Region: TOP4c; smart00434
700598004022	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
700598004023	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598004024	active site
700598004025	motif I; other site
700598004026	motif II; other site
700598004027	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
700598004028	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
700598004029	putative DNA binding site [nucleotide binding]; other site
700598004030	putative homodimer interface [polypeptide binding]; other site
700598004031	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
700598004032	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
700598004033	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
700598004034	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
700598004035	active site
700598004036	DNA binding site [nucleotide binding]
700598004037	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
700598004038	DNA binding site [nucleotide binding]
700598004039	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
700598004040	nucleotide binding site [chemical binding]; other site
700598004041	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
700598004042	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598004043	nucleophilic elbow; other site
700598004044	catalytic triad; other site
700598004045	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598004046	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700598004047	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
700598004048	acetyl-CoA C-acetyltransferase; Region: PLN02644
700598004049	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700598004050	dimer interface [polypeptide binding]; other site
700598004051	active site
700598004052	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700598004053	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598004054	Coenzyme A binding pocket [chemical binding]; other site
700598004055	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
700598004056	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
700598004057	dimer interface [polypeptide binding]; other site
700598004058	ssDNA binding site [nucleotide binding]; other site
700598004059	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700598004060	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598004061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004062	active site
700598004063	phosphorylation site [posttranslational modification]
700598004064	intermolecular recognition site; other site
700598004065	dimerization interface [polypeptide binding]; other site
700598004066	LytTr DNA-binding domain; Region: LytTR; smart00850
700598004067	Histidine kinase; Region: His_kinase; pfam06580
700598004068	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
700598004069	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
700598004070	Acyltransferase family; Region: Acyl_transf_3; pfam01757
700598004071	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
700598004072	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
700598004073	alpha subunit interface [polypeptide binding]; other site
700598004074	TPP binding site [chemical binding]; other site
700598004075	heterodimer interface [polypeptide binding]; other site
700598004076	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700598004077	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598004078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598004079	Outer membrane efflux protein; Region: OEP; pfam02321
700598004080	Outer membrane efflux protein; Region: OEP; pfam02321
700598004081	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
700598004082	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598004083	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
700598004084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598004085	putative substrate translocation pore; other site
700598004086	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598004087	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598004088	Ligand Binding Site [chemical binding]; other site
700598004089	Response regulator receiver domain; Region: Response_reg; pfam00072
700598004090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004091	active site
700598004092	phosphorylation site [posttranslational modification]
700598004093	intermolecular recognition site; other site
700598004094	dimerization interface [polypeptide binding]; other site
700598004095	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598004096	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700598004097	Walker A motif; other site
700598004098	ATP binding site [chemical binding]; other site
700598004099	Walker B motif; other site
700598004100	arginine finger; other site
700598004101	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
700598004102	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700598004103	DNA binding residues [nucleotide binding]
700598004104	B12 binding domain; Region: B12-binding_2; pfam02607
700598004105	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
700598004106	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
700598004107	Catalytic site [active]
700598004108	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
700598004109	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
700598004110	active site
700598004111	catalytic motif [active]
700598004112	Zn binding site [ion binding]; other site
700598004113	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
700598004114	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
700598004115	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
700598004116	FAD binding pocket [chemical binding]; other site
700598004117	FAD binding motif [chemical binding]; other site
700598004118	phosphate binding motif [ion binding]; other site
700598004119	beta-alpha-beta structure motif; other site
700598004120	NAD(p) ribose binding residues [chemical binding]; other site
700598004121	NAD binding pocket [chemical binding]; other site
700598004122	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
700598004123	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598004124	catalytic loop [active]
700598004125	iron binding site [ion binding]; other site
700598004126	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
700598004127	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
700598004128	NADP binding site [chemical binding]; other site
700598004129	dimer interface [polypeptide binding]; other site
700598004130	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
700598004131	putative ADP-ribose binding site [chemical binding]; other site
700598004132	putative active site [active]
700598004133	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
700598004134	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
700598004135	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
700598004136	DNA binding site [nucleotide binding]
700598004137	active site
700598004138	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
700598004139	dimer interface [polypeptide binding]; other site
700598004140	putative tRNA-binding site [nucleotide binding]; other site
700598004141	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
700598004142	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598004143	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598004144	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
700598004145	YcxB-like protein; Region: YcxB; pfam14317
700598004146	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
700598004147	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
700598004148	active site
700598004149	interdomain interaction site; other site
700598004150	putative metal-binding site [ion binding]; other site
700598004151	nucleotide binding site [chemical binding]; other site
700598004152	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
700598004153	domain I; other site
700598004154	DNA binding groove [nucleotide binding]
700598004155	phosphate binding site [ion binding]; other site
700598004156	domain II; other site
700598004157	domain III; other site
700598004158	nucleotide binding site [chemical binding]; other site
700598004159	catalytic site [active]
700598004160	domain IV; other site
700598004161	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
700598004162	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
700598004163	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
700598004164	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
700598004165	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
700598004166	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
700598004167	putative active site [active]
700598004168	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
700598004169	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
700598004170	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
700598004171	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
700598004172	active site
700598004173	catalytic triad [active]
700598004174	oxyanion hole [active]
700598004175	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598004176	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598004177	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598004178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
700598004179	carboxy-terminal protease; Provisional; Region: PRK11186
700598004180	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598004181	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
700598004182	protein binding site [polypeptide binding]; other site
700598004183	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
700598004184	Catalytic dyad [active]
700598004185	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
700598004186	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
700598004187	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598004188	active site
700598004189	motif I; other site
700598004190	motif II; other site
700598004191	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
700598004192	UbiA prenyltransferase family; Region: UbiA; pfam01040
700598004193	Maf-like protein; Region: Maf; pfam02545
700598004194	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
700598004195	active site
700598004196	dimer interface [polypeptide binding]; other site
700598004197	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
700598004198	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598004199	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
700598004200	Ligand binding site; other site
700598004201	Putative Catalytic site; other site
700598004202	DXD motif; other site
700598004203	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
700598004204	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
700598004205	short chain dehydrogenase; Provisional; Region: PRK07041
700598004206	putative NAD(P) binding site [chemical binding]; other site
700598004207	homodimer interface [polypeptide binding]; other site
700598004208	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598004209	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598004210	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598004211	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
700598004212	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
700598004213	N-terminal plug; other site
700598004214	ligand-binding site [chemical binding]; other site
700598004215	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598004216	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598004217	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700598004218	classical (c) SDRs; Region: SDR_c; cd05233
700598004219	NAD(P) binding site [chemical binding]; other site
700598004220	active site
700598004221	Mechanosensitive ion channel; Region: MS_channel; pfam00924
700598004222	short chain dehydrogenase; Provisional; Region: PRK06701
700598004223	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
700598004224	NAD binding site [chemical binding]; other site
700598004225	metal binding site [ion binding]; metal-binding site
700598004226	active site
700598004227	PAS domain; Region: PAS_9; pfam13426
700598004228	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598004229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598004230	dimer interface [polypeptide binding]; other site
700598004231	phosphorylation site [posttranslational modification]
700598004232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598004233	ATP binding site [chemical binding]; other site
700598004234	Mg2+ binding site [ion binding]; other site
700598004235	G-X-G motif; other site
700598004236	Response regulator receiver domain; Region: Response_reg; pfam00072
700598004237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004238	active site
700598004239	phosphorylation site [posttranslational modification]
700598004240	intermolecular recognition site; other site
700598004241	dimerization interface [polypeptide binding]; other site
700598004242	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598004243	dimer interface [polypeptide binding]; other site
700598004244	phosphorylation site [posttranslational modification]
700598004245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598004246	ATP binding site [chemical binding]; other site
700598004247	Mg2+ binding site [ion binding]; other site
700598004248	G-X-G motif; other site
700598004249	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
700598004250	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
700598004251	Pirin-related protein [General function prediction only]; Region: COG1741
700598004252	Pirin; Region: Pirin; pfam02678
700598004253	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
700598004254	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
700598004255	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
700598004256	putative catalytic site [active]
700598004257	putative phosphate binding site [ion binding]; other site
700598004258	active site
700598004259	metal binding site A [ion binding]; metal-binding site
700598004260	DNA binding site [nucleotide binding]
700598004261	putative AP binding site [nucleotide binding]; other site
700598004262	putative metal binding site B [ion binding]; other site
700598004263	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
700598004264	substrate binding site [chemical binding]; other site
700598004265	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
700598004266	putative metal binding site [ion binding]; other site
700598004267	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
700598004268	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
700598004269	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
700598004270	Calx-beta domain; Region: Calx-beta; cl02522
700598004271	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619
700598004272	putative ligand binding site [chemical binding]; other site
700598004273	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619
700598004274	putative ligand binding site [chemical binding]; other site
700598004275	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598004276	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598004277	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598004278	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598004279	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598004280	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598004281	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598004282	SusD family; Region: SusD; pfam07980
700598004283	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
700598004284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598004285	Coenzyme A binding pocket [chemical binding]; other site
700598004286	DoxX-like family; Region: DoxX_2; pfam13564
700598004287	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
700598004288	active site
700598004289	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
700598004290	putative pectinesterase; Region: PLN02432; cl01911
700598004291	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598004292	Active site serine [active]
700598004293	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
700598004294	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
700598004295	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
700598004296	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
700598004297	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
700598004298	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598004299	sugar binding site [chemical binding]; other site
700598004300	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
700598004301	putative metal binding site [ion binding]; other site
700598004302	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598004303	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
700598004304	DEAD-like helicases superfamily; Region: DEXDc; smart00487
700598004305	ATP binding site [chemical binding]; other site
700598004306	Mg++ binding site [ion binding]; other site
700598004307	motif III; other site
700598004308	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598004309	nucleotide binding region [chemical binding]; other site
700598004310	ATP-binding site [chemical binding]; other site
700598004311	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598004312	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
700598004313	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
700598004314	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
700598004315	phosphate binding site [ion binding]; other site
700598004316	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598004317	hydrophobic ligand binding site; other site
700598004318	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700598004319	classical (c) SDRs; Region: SDR_c; cd05233
700598004320	NAD(P) binding site [chemical binding]; other site
700598004321	active site
700598004322	Domain of unknown function (DUF718); Region: DUF718; cl01281
700598004323	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
700598004324	RibD C-terminal domain; Region: RibD_C; cl17279
700598004325	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
700598004326	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
700598004327	B12 binding site [chemical binding]; other site
700598004328	Radical SAM superfamily; Region: Radical_SAM; pfam04055
700598004329	TspO/MBR family; Region: TspO_MBR; pfam03073
700598004330	DinB family; Region: DinB; cl17821
700598004331	DinB superfamily; Region: DinB_2; pfam12867
700598004332	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
700598004333	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700598004334	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598004335	catalytic residue [active]
700598004336	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
700598004337	B12 binding site [chemical binding]; other site
700598004338	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
700598004339	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700598004340	Methyltransferase domain; Region: Methyltransf_12; pfam08242
700598004341	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
700598004342	RibD C-terminal domain; Region: RibD_C; cl17279
700598004343	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
700598004344	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
700598004345	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598004346	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
700598004347	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
700598004348	Interdomain contacts; other site
700598004349	Cytokine receptor motif; other site
700598004350	Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573
700598004351	Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573
700598004352	TANFOR domain; Region: T_forsyth_147; TIGR02542
700598004353	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
700598004354	Interdomain contacts; other site
700598004355	Cytokine receptor motif; other site
700598004356	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
700598004357	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
700598004358	PA/protease or protease-like domain interface [polypeptide binding]; other site
700598004359	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
700598004360	Zn binding site [ion binding]; other site
700598004361	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598004362	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
700598004363	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598004364	active site
700598004365	motif I; other site
700598004366	motif II; other site
700598004367	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700598004368	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
700598004369	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598004370	NADP binding site [chemical binding]; other site
700598004371	putative substrate binding site [chemical binding]; other site
700598004372	active site
700598004373	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
700598004374	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
700598004375	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700598004376	active site
700598004377	Protein of unknown function DUF72; Region: DUF72; pfam01904
700598004378	Predicted integral membrane protein [Function unknown]; Region: COG3548
700598004379	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598004380	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598004381	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598004382	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598004383	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598004384	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
700598004385	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598004386	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598004387	active site
700598004388	catalytic tetrad [active]
700598004389	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598004390	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598004391	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598004392	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598004393	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598004394	short chain dehydrogenase; Provisional; Region: PRK06180
700598004395	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598004396	NADP binding site [chemical binding]; other site
700598004397	active site
700598004398	steroid binding site; other site
700598004399	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598004400	FeS/SAM binding site; other site
700598004401	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
700598004402	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598004403	Histidine kinase; Region: HisKA_3; pfam07730
700598004404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598004405	ATP binding site [chemical binding]; other site
700598004406	Mg2+ binding site [ion binding]; other site
700598004407	G-X-G motif; other site
700598004408	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598004409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004410	active site
700598004411	phosphorylation site [posttranslational modification]
700598004412	intermolecular recognition site; other site
700598004413	dimerization interface [polypeptide binding]; other site
700598004414	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598004415	DNA binding residues [nucleotide binding]
700598004416	dimerization interface [polypeptide binding]; other site
700598004417	GAF domain; Region: GAF; pfam01590
700598004418	GAF domain; Region: GAF_2; pfam13185
700598004419	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
700598004420	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598004421	Walker A motif; other site
700598004422	ATP binding site [chemical binding]; other site
700598004423	Walker B motif; other site
700598004424	arginine finger; other site
700598004425	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
700598004426	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
700598004427	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598004428	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
700598004429	GAF domain; Region: GAF; pfam01590
700598004430	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598004431	Walker A motif; other site
700598004432	ATP binding site [chemical binding]; other site
700598004433	Walker B motif; other site
700598004434	arginine finger; other site
700598004435	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
700598004436	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598004437	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
700598004438	ligand binding site [chemical binding]; other site
700598004439	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598004440	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
700598004441	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598004442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004443	active site
700598004444	phosphorylation site [posttranslational modification]
700598004445	intermolecular recognition site; other site
700598004446	dimerization interface [polypeptide binding]; other site
700598004447	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598004448	DNA binding site [nucleotide binding]
700598004449	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598004450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598004451	dimer interface [polypeptide binding]; other site
700598004452	phosphorylation site [posttranslational modification]
700598004453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598004454	ATP binding site [chemical binding]; other site
700598004455	Mg2+ binding site [ion binding]; other site
700598004456	G-X-G motif; other site
700598004457	Peptidase of plants and bacteria; Region: BSP; pfam04450
700598004458	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598004459	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598004460	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598004461	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598004462	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598004463	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598004464	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
700598004465	BNR repeat-like domain; Region: BNR_2; pfam13088
700598004466	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
700598004467	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598004468	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598004469	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598004470	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
700598004471	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598004472	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
700598004473	SelR domain; Region: SelR; pfam01641
700598004474	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598004475	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598004476	ligand binding site [chemical binding]; other site
700598004477	flexible hinge region; other site
700598004478	Uncharacterized conserved protein [Function unknown]; Region: COG2353
700598004479	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
700598004480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598004481	Walker A/P-loop; other site
700598004482	ATP binding site [chemical binding]; other site
700598004483	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
700598004484	putative active site [active]
700598004485	putative metal-binding site [ion binding]; other site
700598004486	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
700598004487	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
700598004488	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
700598004489	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700598004490	active site
700598004491	ATP binding site [chemical binding]; other site
700598004492	substrate binding site [chemical binding]; other site
700598004493	activation loop (A-loop); other site
700598004494	P63C domain; Region: P63C; pfam10546
700598004495	hypothetical protein; Validated; Region: PRK08116
700598004496	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
700598004497	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
700598004498	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
700598004499	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598004500	non-specific DNA binding site [nucleotide binding]; other site
700598004501	salt bridge; other site
700598004502	sequence-specific DNA binding site [nucleotide binding]; other site
700598004503	HEPN domain; Region: HEPN; pfam05168
700598004504	Response regulator receiver domain; Region: Response_reg; pfam00072
700598004505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004506	active site
700598004507	phosphorylation site [posttranslational modification]
700598004508	intermolecular recognition site; other site
700598004509	dimerization interface [polypeptide binding]; other site
700598004510	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
700598004511	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
700598004512	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598004513	hydrophobic ligand binding site; other site
700598004514	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598004515	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598004516	short chain dehydrogenase; Validated; Region: PRK06182
700598004517	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598004518	NADP binding site [chemical binding]; other site
700598004519	active site
700598004520	steroid binding site; other site
700598004521	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
700598004522	Secretin and TonB N terminus short domain; Region: STN; smart00965
700598004523	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598004524	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598004525	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598004526	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598004527	FecR protein; Region: FecR; pfam04773
700598004528	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598004529	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598004530	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598004531	DNA binding residues [nucleotide binding]
700598004532	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
700598004533	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700598004534	classical (c) SDRs; Region: SDR_c; cd05233
700598004535	NAD(P) binding site [chemical binding]; other site
700598004536	active site
700598004537	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
700598004538	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
700598004539	Predicted membrane protein [Function unknown]; Region: COG4682
700598004540	yiaA/B two helix domain; Region: YiaAB; pfam05360
700598004541	yiaA/B two helix domain; Region: YiaAB; pfam05360
700598004542	Histidine kinase; Region: HisKA_3; pfam07730
700598004543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598004544	ATP binding site [chemical binding]; other site
700598004545	Mg2+ binding site [ion binding]; other site
700598004546	G-X-G motif; other site
700598004547	Response regulator receiver domain; Region: Response_reg; pfam00072
700598004548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004549	active site
700598004550	phosphorylation site [posttranslational modification]
700598004551	intermolecular recognition site; other site
700598004552	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598004553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004554	active site
700598004555	phosphorylation site [posttranslational modification]
700598004556	intermolecular recognition site; other site
700598004557	dimerization interface [polypeptide binding]; other site
700598004558	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598004559	DNA binding residues [nucleotide binding]
700598004560	dimerization interface [polypeptide binding]; other site
700598004561	PAS domain S-box; Region: sensory_box; TIGR00229
700598004562	PAS domain; Region: PAS; smart00091
700598004563	putative active site [active]
700598004564	heme pocket [chemical binding]; other site
700598004565	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598004566	Histidine kinase; Region: HisKA_3; pfam07730
700598004567	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598004568	ATP binding site [chemical binding]; other site
700598004569	Mg2+ binding site [ion binding]; other site
700598004570	G-X-G motif; other site
700598004571	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
700598004572	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700598004573	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
700598004574	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
700598004575	PhnA protein; Region: PhnA; pfam03831
700598004576	putative carbohydrate kinase; Provisional; Region: PRK10565
700598004577	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
700598004578	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
700598004579	putative substrate binding site [chemical binding]; other site
700598004580	putative ATP binding site [chemical binding]; other site
700598004581	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598004582	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598004583	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
700598004584	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
700598004585	ligand binding site [chemical binding]; other site
700598004586	NAD binding site [chemical binding]; other site
700598004587	tetramer interface [polypeptide binding]; other site
700598004588	catalytic site [active]
700598004589	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
700598004590	L-serine binding site [chemical binding]; other site
700598004591	ACT domain interface; other site
700598004592	DoxX-like family; Region: DoxX_2; pfam13564
700598004593	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
700598004594	putative ligand binding site [chemical binding]; other site
700598004595	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598004596	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598004597	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700598004598	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
700598004599	Pathogenicity locus; Region: Cdd1; pfam11731
700598004600	TIR domain; Region: TIR_2; pfam13676
700598004601	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
700598004602	structural tetrad; other site
700598004603	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
700598004604	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
700598004605	structural tetrad; other site
700598004606	FOG: WD40 repeat [General function prediction only]; Region: COG2319
700598004607	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
700598004608	structural tetrad; other site
700598004609	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; cl02380
700598004610	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
700598004611	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598004612	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598004613	active site
700598004614	malate:quinone oxidoreductase; Validated; Region: PRK05257
700598004615	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
700598004616	Response regulator receiver domain; Region: Response_reg; pfam00072
700598004617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004618	active site
700598004619	phosphorylation site [posttranslational modification]
700598004620	intermolecular recognition site; other site
700598004621	dimerization interface [polypeptide binding]; other site
700598004622	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598004623	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598004624	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598004625	DNA binding residues [nucleotide binding]
700598004626	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
700598004627	Transposase; Region: DEDD_Tnp_IS110; pfam01548
700598004628	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
700598004629	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
700598004630	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598004631	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598004632	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598004633	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598004634	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598004635	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598004636	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598004637	FecR protein; Region: FecR; pfam04773
700598004638	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598004639	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598004640	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598004641	DNA binding residues [nucleotide binding]
700598004642	Protein of unknown function (DUF1593); Region: DUF1593; pfam07632
700598004643	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
700598004644	putative pectinesterase; Region: PLN02432; cl01911
700598004645	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
700598004646	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
700598004647	Cytokine receptor motif; other site
700598004648	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598004649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004650	active site
700598004651	phosphorylation site [posttranslational modification]
700598004652	intermolecular recognition site; other site
700598004653	dimerization interface [polypeptide binding]; other site
700598004654	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
700598004655	Interdomain contacts; other site
700598004656	Cytokine receptor motif; other site
700598004657	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598004658	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004659	active site
700598004660	phosphorylation site [posttranslational modification]
700598004661	intermolecular recognition site; other site
700598004662	dimerization interface [polypeptide binding]; other site
700598004663	Response regulator receiver domain; Region: Response_reg; pfam00072
700598004664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004665	active site
700598004666	phosphorylation site [posttranslational modification]
700598004667	intermolecular recognition site; other site
700598004668	dimerization interface [polypeptide binding]; other site
700598004669	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
700598004670	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
700598004671	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
700598004672	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598004673	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
700598004674	Protein of unknown function (DUF420); Region: DUF420; pfam04238
700598004675	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598004676	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598004677	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
700598004678	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
700598004679	putative ion selectivity filter; other site
700598004680	putative pore gating glutamate residue; other site
700598004681	putative H+/Cl- coupling transport residue; other site
700598004682	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
700598004683	dimerization interface [polypeptide binding]; other site
700598004684	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598004685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004686	active site
700598004687	phosphorylation site [posttranslational modification]
700598004688	intermolecular recognition site; other site
700598004689	dimerization interface [polypeptide binding]; other site
700598004690	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598004691	DNA binding site [nucleotide binding]
700598004692	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598004693	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598004694	dimerization interface [polypeptide binding]; other site
700598004695	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598004696	dimer interface [polypeptide binding]; other site
700598004697	phosphorylation site [posttranslational modification]
700598004698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598004699	ATP binding site [chemical binding]; other site
700598004700	Mg2+ binding site [ion binding]; other site
700598004701	G-X-G motif; other site
700598004702	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598004703	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598004704	dimer interface [polypeptide binding]; other site
700598004705	phosphorylation site [posttranslational modification]
700598004706	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598004707	ATP binding site [chemical binding]; other site
700598004708	Mg2+ binding site [ion binding]; other site
700598004709	G-X-G motif; other site
700598004710	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
700598004711	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
700598004712	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700598004713	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
700598004714	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598004715	motif II; other site
700598004716	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
700598004717	Response regulator receiver domain; Region: Response_reg; pfam00072
700598004718	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004719	active site
700598004720	phosphorylation site [posttranslational modification]
700598004721	intermolecular recognition site; other site
700598004722	dimerization interface [polypeptide binding]; other site
700598004723	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598004724	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598004725	ligand binding site [chemical binding]; other site
700598004726	flexible hinge region; other site
700598004727	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700598004728	non-specific DNA interactions [nucleotide binding]; other site
700598004729	DNA binding site [nucleotide binding]
700598004730	sequence specific DNA binding site [nucleotide binding]; other site
700598004731	putative cAMP binding site [chemical binding]; other site
700598004732	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
700598004733	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
700598004734	putative substrate binding site [chemical binding]; other site
700598004735	putative ATP binding site [chemical binding]; other site
700598004736	PAS domain S-box; Region: sensory_box; TIGR00229
700598004737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598004738	putative active site [active]
700598004739	heme pocket [chemical binding]; other site
700598004740	PAS domain S-box; Region: sensory_box; TIGR00229
700598004741	PAS domain; Region: PAS; smart00091
700598004742	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598004743	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598004744	dimer interface [polypeptide binding]; other site
700598004745	phosphorylation site [posttranslational modification]
700598004746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598004747	ATP binding site [chemical binding]; other site
700598004748	Mg2+ binding site [ion binding]; other site
700598004749	G-X-G motif; other site
700598004750	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
700598004751	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
700598004752	Ras-like protein; Provisional; Region: PTZ00369
700598004753	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
700598004754	BON domain; Region: BON; pfam04972
700598004755	BON domain; Region: BON; pfam04972
700598004756	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700598004757	mce related protein; Region: MCE; pfam02470
700598004758	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
700598004759	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
700598004760	Walker A/P-loop; other site
700598004761	ATP binding site [chemical binding]; other site
700598004762	Q-loop/lid; other site
700598004763	ABC transporter signature motif; other site
700598004764	Walker B; other site
700598004765	D-loop; other site
700598004766	H-loop/switch region; other site
700598004767	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700598004768	Permease; Region: Permease; pfam02405
700598004769	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
700598004770	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
700598004771	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598004772	Family of unknown function (DUF490); Region: DUF490; pfam04357
700598004773	phosphoenolpyruvate synthase; Validated; Region: PRK06464
700598004774	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
700598004775	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
700598004776	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
700598004777	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
700598004778	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
700598004779	putative dimer interface [polypeptide binding]; other site
700598004780	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700598004781	Permease; Region: Permease; pfam02405
700598004782	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
700598004783	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
700598004784	Walker A/P-loop; other site
700598004785	ATP binding site [chemical binding]; other site
700598004786	Q-loop/lid; other site
700598004787	ABC transporter signature motif; other site
700598004788	Walker B; other site
700598004789	D-loop; other site
700598004790	H-loop/switch region; other site
700598004791	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
700598004792	mce related protein; Region: MCE; pfam02470
700598004793	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700598004794	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
700598004795	catalytic Zn binding site [ion binding]; other site
700598004796	structural Zn binding site [ion binding]; other site
700598004797	NAD(P) binding site [chemical binding]; other site
700598004798	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
700598004799	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
700598004800	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700598004801	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700598004802	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
700598004803	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
700598004804	Ligand Binding Site [chemical binding]; other site
700598004805	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598004806	Ligand Binding Site [chemical binding]; other site
700598004807	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598004808	Ligand Binding Site [chemical binding]; other site
700598004809	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598004810	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
700598004811	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
700598004812	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
700598004813	putative dimer interface [polypeptide binding]; other site
700598004814	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
700598004815	BON domain; Region: BON; pfam04972
700598004816	BON domain; Region: BON; pfam04972
700598004817	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
700598004818	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
700598004819	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
700598004820	ApbE family; Region: ApbE; pfam02424
700598004821	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
700598004822	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598004823	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
700598004824	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700598004825	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700598004826	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
700598004827	Peptidase family M50; Region: Peptidase_M50; pfam02163
700598004828	active site
700598004829	putative substrate binding region [chemical binding]; other site
700598004830	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
700598004831	FOG: CBS domain [General function prediction only]; Region: COG0517
700598004832	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
700598004833	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598004834	Walker A motif; other site
700598004835	ATP binding site [chemical binding]; other site
700598004836	Walker B motif; other site
700598004837	arginine finger; other site
700598004838	Peptidase family M41; Region: Peptidase_M41; pfam01434
700598004839	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
700598004840	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700598004841	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700598004842	Walker A/P-loop; other site
700598004843	ATP binding site [chemical binding]; other site
700598004844	Q-loop/lid; other site
700598004845	ABC transporter signature motif; other site
700598004846	Walker B; other site
700598004847	D-loop; other site
700598004848	H-loop/switch region; other site
700598004849	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
700598004850	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598004851	FtsX-like permease family; Region: FtsX; pfam02687
700598004852	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598004853	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598004854	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
700598004855	substrate binding site [chemical binding]; other site
700598004856	THF binding site; other site
700598004857	zinc-binding site [ion binding]; other site
700598004858	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
700598004859	putative active site [active]
700598004860	putative metal binding site [ion binding]; other site
700598004861	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
700598004862	putative metal binding site; other site
700598004863	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598004864	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598004865	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598004866	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
700598004867	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
700598004868	Zn binding site [ion binding]; other site
700598004869	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
700598004870	putative hydrophobic ligand binding site [chemical binding]; other site
700598004871	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598004872	dimerization interface [polypeptide binding]; other site
700598004873	putative DNA binding site [nucleotide binding]; other site
700598004874	putative Zn2+ binding site [ion binding]; other site
700598004875	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598004876	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598004877	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598004878	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598004879	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598004880	SusD family; Region: SusD; pfam07980
700598004881	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598004882	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598004883	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598004884	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598004885	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598004886	ligand binding site [chemical binding]; other site
700598004887	flexible hinge region; other site
700598004888	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700598004889	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700598004890	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
700598004891	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598004892	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598004893	DNA binding residues [nucleotide binding]
700598004894	DoxX-like family; Region: DoxX_2; pfam13564
700598004895	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598004896	Cupin domain; Region: Cupin_2; pfam07883
700598004897	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
700598004898	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
700598004899	FOG: WD40 repeat [General function prediction only]; Region: COG2319
700598004900	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
700598004901	structural tetrad; other site
700598004902	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
700598004903	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598004904	FeS/SAM binding site; other site
700598004905	HemN C-terminal domain; Region: HemN_C; pfam06969
700598004906	Response regulator receiver domain; Region: Response_reg; pfam00072
700598004907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598004908	active site
700598004909	phosphorylation site [posttranslational modification]
700598004910	intermolecular recognition site; other site
700598004911	dimerization interface [polypeptide binding]; other site
700598004912	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598004913	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598004914	ligand binding site [chemical binding]; other site
700598004915	flexible hinge region; other site
700598004916	putative switch regulator; other site
700598004917	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
700598004918	non-specific DNA interactions [nucleotide binding]; other site
700598004919	DNA binding site [nucleotide binding]
700598004920	sequence specific DNA binding site [nucleotide binding]; other site
700598004921	putative cAMP binding site [chemical binding]; other site
700598004922	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
700598004923	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
700598004924	Heavy-metal-associated domain; Region: HMA; pfam00403
700598004925	metal-binding site [ion binding]
700598004926	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700598004927	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598004928	motif II; other site
700598004929	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
700598004930	putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485
700598004931	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
700598004932	Low-spin heme binding site [chemical binding]; other site
700598004933	Putative water exit pathway; other site
700598004934	Binuclear center (active site) [active]
700598004935	Putative proton exit pathway; other site
700598004936	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
700598004937	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
700598004938	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
700598004939	4Fe-4S binding domain; Region: Fer4_5; pfam12801
700598004940	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
700598004941	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
700598004942	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
700598004943	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
700598004944	FixH; Region: FixH; pfam05751
700598004945	Family description; Region: DsbD_2; pfam13386
700598004946	PAS domain S-box; Region: sensory_box; TIGR00229
700598004947	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598004948	putative active site [active]
700598004949	heme pocket [chemical binding]; other site
700598004950	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598004951	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598004952	dimer interface [polypeptide binding]; other site
700598004953	phosphorylation site [posttranslational modification]
700598004954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598004955	ATP binding site [chemical binding]; other site
700598004956	Mg2+ binding site [ion binding]; other site
700598004957	G-X-G motif; other site
700598004958	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
700598004959	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
700598004960	Hemerythrin-like domain; Region: Hr-like; cd12108
700598004961	Fe binding site [ion binding]; other site
700598004962	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
700598004963	putative substrate binding site [chemical binding]; other site
700598004964	active site
700598004965	murein hydrolase B; Provisional; Region: PRK10760; cl17906
700598004966	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
700598004967	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598004968	FtsX-like permease family; Region: FtsX; pfam02687
700598004969	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598004970	FtsX-like permease family; Region: FtsX; pfam02687
700598004971	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598004972	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598004973	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
700598004974	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
700598004975	active site
700598004976	nucleophile elbow; other site
700598004977	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
700598004978	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
700598004979	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
700598004980	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
700598004981	proposed catalytic triad [active]
700598004982	active site nucleophile [active]
700598004983	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700598004984	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
700598004985	heme binding pocket [chemical binding]; other site
700598004986	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
700598004987	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700598004988	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
700598004989	Walker A/P-loop; other site
700598004990	ATP binding site [chemical binding]; other site
700598004991	Q-loop/lid; other site
700598004992	ABC transporter signature motif; other site
700598004993	Walker B; other site
700598004994	D-loop; other site
700598004995	H-loop/switch region; other site
700598004996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700598004997	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
700598004998	dimer interface [polypeptide binding]; other site
700598004999	conserved gate region; other site
700598005000	putative PBP binding loops; other site
700598005001	ABC-ATPase subunit interface; other site
700598005002	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
700598005003	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
700598005004	GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323
700598005005	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598005006	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598005007	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598005008	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598005009	DinB superfamily; Region: DinB_2; pfam12867
700598005010	Integral membrane protein DUF92; Region: DUF92; pfam01940
700598005011	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
700598005012	AAA domain; Region: AAA_11; pfam13086
700598005013	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598005014	ATP binding site [chemical binding]; other site
700598005015	putative Mg++ binding site [ion binding]; other site
700598005016	AAA domain; Region: AAA_12; pfam13087
700598005017	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598005018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598005019	active site
700598005020	phosphorylation site [posttranslational modification]
700598005021	intermolecular recognition site; other site
700598005022	dimerization interface [polypeptide binding]; other site
700598005023	Domain of unknown function DUF11; Region: DUF11; cl17728
700598005024	conserved repeat domain; Region: B_ant_repeat; TIGR01451
700598005025	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
700598005026	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598005027	YCII-related domain; Region: YCII; cl00999
700598005028	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
700598005029	EamA-like transporter family; Region: EamA; pfam00892
700598005030	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
700598005031	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
700598005032	trimer interface [polypeptide binding]; other site
700598005033	active site
700598005034	substrate binding site [chemical binding]; other site
700598005035	CoA binding site [chemical binding]; other site
700598005036	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
700598005037	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
700598005038	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
700598005039	putative active site [active]
700598005040	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
700598005041	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
700598005042	active site
700598005043	NTP binding site [chemical binding]; other site
700598005044	metal binding triad [ion binding]; metal-binding site
700598005045	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
700598005046	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700598005047	Zn2+ binding site [ion binding]; other site
700598005048	Mg2+ binding site [ion binding]; other site
700598005049	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
700598005050	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
700598005051	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
700598005052	Domain of unknown function (DUF4302); Region: DUF4302; pfam14135
700598005053	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598005054	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598005055	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598005056	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598005057	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598005058	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598005059	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598005060	FecR protein; Region: FecR; pfam04773
700598005061	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598005062	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598005063	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598005064	DNA binding residues [nucleotide binding]
700598005065	prolyl-tRNA synthetase; Provisional; Region: PRK08661
700598005066	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
700598005067	dimer interface [polypeptide binding]; other site
700598005068	motif 1; other site
700598005069	active site
700598005070	motif 2; other site
700598005071	motif 3; other site
700598005072	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
700598005073	anticodon binding site; other site
700598005074	zinc-binding site [ion binding]; other site
700598005075	RDD family; Region: RDD; pfam06271
700598005076	Integral membrane protein DUF95; Region: DUF95; pfam01944
700598005077	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
700598005078	MoxR-like ATPases [General function prediction only]; Region: COG0714
700598005079	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598005080	Walker A motif; other site
700598005081	ATP binding site [chemical binding]; other site
700598005082	Walker B motif; other site
700598005083	arginine finger; other site
700598005084	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
700598005085	Protein of unknown function DUF58; Region: DUF58; pfam01882
700598005086	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
700598005087	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
700598005088	RNA binding site [nucleotide binding]; other site
700598005089	active site
700598005090	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
700598005091	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598005092	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
700598005093	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
700598005094	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
700598005095	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
700598005096	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
700598005097	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
700598005098	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
700598005099	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
700598005100	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
700598005101	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
700598005102	TraB family; Region: TraB; pfam01963
700598005103	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
700598005104	active site
700598005105	multimer interface [polypeptide binding]; other site
700598005106	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
700598005107	DHH family; Region: DHH; pfam01368
700598005108	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
700598005109	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
700598005110	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
700598005111	dihydropteroate synthase; Region: DHPS; TIGR01496
700598005112	substrate binding pocket [chemical binding]; other site
700598005113	dimer interface [polypeptide binding]; other site
700598005114	inhibitor binding site; inhibition site
700598005115	DoxX; Region: DoxX; pfam07681
700598005116	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
700598005117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700598005118	dimer interface [polypeptide binding]; other site
700598005119	conserved gate region; other site
700598005120	putative PBP binding loops; other site
700598005121	ABC-ATPase subunit interface; other site
700598005122	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
700598005123	Strictosidine synthase; Region: Str_synth; pfam03088
700598005124	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
700598005125	active site clefts [active]
700598005126	zinc binding site [ion binding]; other site
700598005127	dimer interface [polypeptide binding]; other site
700598005128	Protein of unknown function (DUF721); Region: DUF721; pfam05258
700598005129	recombination protein F; Reviewed; Region: recF; PRK00064
700598005130	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598005131	Walker A/P-loop; other site
700598005132	ATP binding site [chemical binding]; other site
700598005133	Q-loop/lid; other site
700598005134	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598005135	ABC transporter signature motif; other site
700598005136	Walker B; other site
700598005137	D-loop; other site
700598005138	H-loop/switch region; other site
700598005139	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
700598005140	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
700598005141	tetramer interface [polypeptide binding]; other site
700598005142	TPP-binding site [chemical binding]; other site
700598005143	heterodimer interface [polypeptide binding]; other site
700598005144	phosphorylation loop region [posttranslational modification]
700598005145	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598005146	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598005147	binding surface
700598005148	TPR motif; other site
700598005149	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598005150	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
700598005151	homopentamer interface [polypeptide binding]; other site
700598005152	active site
700598005153	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
700598005154	Cysteine-rich domain; Region: CCG; pfam02754
700598005155	Cysteine-rich domain; Region: CCG; pfam02754
700598005156	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
700598005157	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
700598005158	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
700598005159	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
700598005160	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
700598005161	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
700598005162	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700598005163	RNA binding surface [nucleotide binding]; other site
700598005164	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
700598005165	probable active site [active]
700598005166	RibD C-terminal domain; Region: RibD_C; cl17279
700598005167	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
700598005168	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
700598005169	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
700598005170	active site
700598005171	SnoaL-like domain; Region: SnoaL_2; pfam12680
700598005172	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598005173	Histidine kinase; Region: His_kinase; pfam06580
700598005174	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598005175	binding surface
700598005176	TPR motif; other site
700598005177	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598005178	Histidine kinase; Region: His_kinase; pfam06580
700598005179	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598005180	Response regulator receiver domain; Region: Response_reg; pfam00072
700598005181	active site
700598005182	phosphorylation site [posttranslational modification]
700598005183	intermolecular recognition site; other site
700598005184	dimerization interface [polypeptide binding]; other site
700598005185	LytTr DNA-binding domain; Region: LytTR; smart00850
700598005186	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598005187	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598005188	short chain dehydrogenase; Provisional; Region: PRK08263
700598005189	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598005190	NADP binding site [chemical binding]; other site
700598005191	active site
700598005192	steroid binding site; other site
700598005193	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598005194	putative mechanosensitive channel protein; Provisional; Region: PRK10929
700598005195	SnoaL-like domain; Region: SnoaL_3; pfam13474
700598005196	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
700598005197	active site residue [active]
700598005198	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598005199	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598005200	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598005201	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598005202	TPR motif; other site
700598005203	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
700598005204	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
700598005205	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
700598005206	Fasciclin domain; Region: Fasciclin; pfam02469
700598005207	EVE domain; Region: EVE; pfam01878
700598005208	von Willebrand factor; Region: vWF_A; pfam12450
700598005209	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
700598005210	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
700598005211	metal ion-dependent adhesion site (MIDAS); other site
700598005212	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
700598005213	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
700598005214	NAD-dependent deacetylase; Provisional; Region: PRK00481
700598005215	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
700598005216	NAD+ binding site [chemical binding]; other site
700598005217	substrate binding site [chemical binding]; other site
700598005218	Zn binding site [ion binding]; other site
700598005219	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
700598005220	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
700598005221	lysine-ketoglutarate reductase/saccharopine dehydrogenase; Region: PLN02819
700598005222	lysine-ketoglutarate reductase/saccharopine dehydrogenase; Region: PLN02819
700598005223	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
700598005224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598005225	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598005226	dimer interface [polypeptide binding]; other site
700598005227	phosphorylation site [posttranslational modification]
700598005228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598005229	ATP binding site [chemical binding]; other site
700598005230	Mg2+ binding site [ion binding]; other site
700598005231	G-X-G motif; other site
700598005232	DNA gyrase subunit A; Validated; Region: PRK05560
700598005233	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
700598005234	CAP-like domain; other site
700598005235	active site
700598005236	primary dimer interface [polypeptide binding]; other site
700598005237	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700598005238	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700598005239	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700598005240	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700598005241	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700598005242	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598005243	TPR motif; other site
700598005244	binding surface
700598005245	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
700598005246	FMN binding site [chemical binding]; other site
700598005247	dimer interface [polypeptide binding]; other site
700598005248	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
700598005249	catalytic motif [active]
700598005250	Catalytic residue [active]
700598005251	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598005252	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598005253	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598005254	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
700598005255	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598005256	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
700598005257	Walker A/P-loop; other site
700598005258	ATP binding site [chemical binding]; other site
700598005259	Q-loop/lid; other site
700598005260	ABC transporter signature motif; other site
700598005261	Walker B; other site
700598005262	D-loop; other site
700598005263	H-loop/switch region; other site
700598005264	glucokinase, proteobacterial type; Region: glk; TIGR00749
700598005265	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700598005266	nucleotide binding site [chemical binding]; other site
700598005267	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598005268	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598005269	Uncharacterized conserved protein [Function unknown]; Region: COG1912
700598005270	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
700598005271	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598005272	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
700598005273	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700598005274	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598005275	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598005276	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598005277	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
700598005278	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
700598005279	Moco binding site; other site
700598005280	metal coordination site [ion binding]; other site
700598005281	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598005282	Radical SAM superfamily; Region: Radical_SAM; pfam04055
700598005283	FeS/SAM binding site; other site
700598005284	DinB superfamily; Region: DinB_2; pfam12867
700598005285	hypothetical protein; Provisional; Region: PRK10621
700598005286	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700598005287	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
700598005288	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700598005289	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
700598005290	dimer interface [polypeptide binding]; other site
700598005291	ADP-ribose binding site [chemical binding]; other site
700598005292	active site
700598005293	nudix motif; other site
700598005294	metal binding site [ion binding]; metal-binding site
700598005295	metal-dependent hydrolase; Provisional; Region: PRK13291
700598005296	DinB superfamily; Region: DinB_2; pfam12867
700598005297	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700598005298	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
700598005299	Walker A/P-loop; other site
700598005300	ATP binding site [chemical binding]; other site
700598005301	Q-loop/lid; other site
700598005302	ABC transporter signature motif; other site
700598005303	Walker B; other site
700598005304	D-loop; other site
700598005305	H-loop/switch region; other site
700598005306	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
700598005307	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
700598005308	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
700598005309	AMP binding site [chemical binding]; other site
700598005310	metal binding site [ion binding]; metal-binding site
700598005311	active site
700598005312	Pyrococcus aspartate kinase subunit, putative; Region: AspKin_pair; TIGR02078
700598005313	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
700598005314	nucleotide binding site [chemical binding]; other site
700598005315	substrate binding site [chemical binding]; other site
700598005316	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
700598005317	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700598005318	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598005319	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598005320	Walker A/P-loop; other site
700598005321	ATP binding site [chemical binding]; other site
700598005322	Q-loop/lid; other site
700598005323	ABC transporter signature motif; other site
700598005324	Walker B; other site
700598005325	D-loop; other site
700598005326	H-loop/switch region; other site
700598005327	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
700598005328	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
700598005329	nucleotide binding site [chemical binding]; other site
700598005330	NEF interaction site [polypeptide binding]; other site
700598005331	SBD interface [polypeptide binding]; other site
700598005332	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
700598005333	amidase catalytic site [active]
700598005334	Zn binding residues [ion binding]; other site
700598005335	substrate binding site [chemical binding]; other site
700598005336	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
700598005337	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598005338	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598005339	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598005340	Thioredoxin; Region: Thioredoxin_4; pfam13462
700598005341	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
700598005342	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598005343	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
700598005344	Predicted membrane protein [Function unknown]; Region: COG2246
700598005345	GtrA-like protein; Region: GtrA; pfam04138
700598005346	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
700598005347	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598005348	active site
700598005349	HIGH motif; other site
700598005350	nucleotide binding site [chemical binding]; other site
700598005351	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
700598005352	KMSK motif region; other site
700598005353	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
700598005354	tRNA binding surface [nucleotide binding]; other site
700598005355	anticodon binding site; other site
700598005356	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598005357	binding surface
700598005358	TPR motif; other site
700598005359	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
700598005360	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598005361	TPR motif; other site
700598005362	binding surface
700598005363	TPR repeat; Region: TPR_11; pfam13414
700598005364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598005365	binding surface
700598005366	TPR motif; other site
700598005367	TPR repeat; Region: TPR_11; pfam13414
700598005368	glycogen branching enzyme; Provisional; Region: PRK12313
700598005369	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
700598005370	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
700598005371	active site
700598005372	catalytic site [active]
700598005373	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
700598005374	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598005375	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598005376	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598005377	GLPGLI family protein; Region: GLPGLI; TIGR01200
700598005378	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598005379	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
700598005380	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
700598005381	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
700598005382	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598005383	ligand binding site [chemical binding]; other site
700598005384	The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563
700598005385	Predicted integral membrane protein [Function unknown]; Region: COG5616
700598005386	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
700598005387	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598005388	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598005389	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
700598005390	DNA binding residues [nucleotide binding]
700598005391	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598005392	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598005393	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598005394	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
700598005395	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
700598005396	active site
700598005397	homodimer interface [polypeptide binding]; other site
700598005398	homotetramer interface [polypeptide binding]; other site
700598005399	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
700598005400	Aspartase; Region: Aspartase; cd01357
700598005401	active sites [active]
700598005402	tetramer interface [polypeptide binding]; other site
700598005403	Protein of unknown function, DUF481; Region: DUF481; cl01213
700598005404	Glutaminase; Region: Glutaminase; cl00907
700598005405	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
700598005406	Amidohydrolase; Region: Amidohydro_2; pfam04909
700598005407	Predicted integral membrane protein [Function unknown]; Region: COG5616
700598005408	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
700598005409	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598005410	ligand binding site [chemical binding]; other site
700598005411	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
700598005412	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598005413	Epoxide hydrolase N terminus; Region: EHN; pfam06441
700598005414	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598005415	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
700598005416	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
700598005417	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
700598005418	Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087
700598005419	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340
700598005420	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
700598005421	Ca binding site [ion binding]; other site
700598005422	active site
700598005423	homodimer interface [polypeptide binding]; other site
700598005424	catalytic site [active]
700598005425	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
700598005426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598005427	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598005428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598005429	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
700598005430	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
700598005431	ligand binding site; other site
700598005432	oligomer interface; other site
700598005433	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
700598005434	dimer interface [polypeptide binding]; other site
700598005435	N-terminal domain interface [polypeptide binding]; other site
700598005436	sulfate 1 binding site; other site
700598005437	glycogen synthase; Provisional; Region: glgA; PRK00654
700598005438	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
700598005439	ADP-binding pocket [chemical binding]; other site
700598005440	homodimer interface [polypeptide binding]; other site
700598005441	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
700598005442	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598005443	putative substrate translocation pore; other site
700598005444	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700598005445	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700598005446	nucleotide binding site [chemical binding]; other site
700598005447	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
700598005448	lipoyl synthase; Provisional; Region: PRK05481
700598005449	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598005450	FeS/SAM binding site; other site
700598005451	OsmC-like protein; Region: OsmC; pfam02566
700598005452	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700598005453	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
700598005454	FOG: CBS domain [General function prediction only]; Region: COG0517
700598005455	Acyl CoA binding protein; Region: ACBP; pfam00887
700598005456	acyl-CoA binding pocket [chemical binding]; other site
700598005457	CoA binding site [chemical binding]; other site
700598005458	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
700598005459	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
700598005460	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
700598005461	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598005462	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
700598005463	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598005464	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
700598005465	triosephosphate isomerase; Provisional; Region: PRK14567
700598005466	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
700598005467	substrate binding site [chemical binding]; other site
700598005468	dimer interface [polypeptide binding]; other site
700598005469	catalytic triad [active]
700598005470	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
700598005471	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
700598005472	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
700598005473	putative trimer interface [polypeptide binding]; other site
700598005474	putative CoA binding site [chemical binding]; other site
700598005475	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
700598005476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
700598005477	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
700598005478	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598005479	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598005480	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598005481	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598005482	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598005483	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598005484	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
700598005485	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
700598005486	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
700598005487	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
700598005488	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
700598005489	putative dimer interface [polypeptide binding]; other site
700598005490	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
700598005491	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
700598005492	dimer interface [polypeptide binding]; other site
700598005493	active site
700598005494	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700598005495	catalytic residues [active]
700598005496	substrate binding site [chemical binding]; other site
700598005497	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
700598005498	23S rRNA binding site [nucleotide binding]; other site
700598005499	L21 binding site [polypeptide binding]; other site
700598005500	L13 binding site [polypeptide binding]; other site
700598005501	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
700598005502	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
700598005503	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
700598005504	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
700598005505	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
700598005506	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
700598005507	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
700598005508	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
700598005509	active site
700598005510	dimer interface [polypeptide binding]; other site
700598005511	motif 1; other site
700598005512	motif 2; other site
700598005513	motif 3; other site
700598005514	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
700598005515	anticodon binding site; other site
700598005516	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
700598005517	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598005518	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598005519	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598005520	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
700598005521	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
700598005522	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700598005523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598005524	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700598005525	ABC transporter signature motif; other site
700598005526	Walker B; other site
700598005527	ABC transporter; Region: ABC_tran_2; pfam12848
700598005528	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700598005529	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
700598005530	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598005531	Coenzyme A binding pocket [chemical binding]; other site
700598005532	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
700598005533	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
700598005534	active site
700598005535	nucleophile elbow; other site
700598005536	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
700598005537	putative active site [active]
700598005538	putative metal binding site [ion binding]; other site
700598005539	Site-specific recombinase; Region: SpecificRecomb; cl15411
700598005540	imidazolonepropionase; Validated; Region: PRK09356
700598005541	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
700598005542	active site
700598005543	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
700598005544	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
700598005545	active site
700598005546	homotetramer interface [polypeptide binding]; other site
700598005547	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
700598005548	urocanate hydratase; Provisional; Region: PRK05414
700598005549	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
700598005550	active sites [active]
700598005551	tetramer interface [polypeptide binding]; other site
700598005552	MarR family; Region: MarR_2; pfam12802
700598005553	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700598005554	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
700598005555	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598005556	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598005557	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700598005558	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
700598005559	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
700598005560	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
700598005561	active site
700598005562	substrate binding site [chemical binding]; other site
700598005563	metal binding site [ion binding]; metal-binding site
700598005564	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
700598005565	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700598005566	active site
700598005567	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
700598005568	4Fe-4S binding domain; Region: Fer4; cl02805
700598005569	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
700598005570	LysE type translocator; Region: LysE; cl00565
700598005571	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
700598005572	YceI-like domain; Region: YceI; pfam04264
700598005573	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700598005574	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
700598005575	putative di-iron ligands [ion binding]; other site
700598005576	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
700598005577	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
700598005578	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598005579	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
700598005580	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
700598005581	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700598005582	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700598005583	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700598005584	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
700598005585	dimerization interface [polypeptide binding]; other site
700598005586	metal binding site [ion binding]; metal-binding site
700598005587	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
700598005588	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
700598005589	putative active site [active]
700598005590	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598005591	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598005592	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598005593	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
700598005594	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
700598005595	putative ADP-binding pocket [chemical binding]; other site
700598005596	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
700598005597	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598005598	active site
700598005599	motif I; other site
700598005600	motif II; other site
700598005601	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
700598005602	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
700598005603	putative active site [active]
700598005604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598005605	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598005606	putative substrate translocation pore; other site
700598005607	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
700598005608	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
700598005609	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
700598005610	metal-binding site [ion binding]
700598005611	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700598005612	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700598005613	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598005614	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598005615	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
700598005616	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
700598005617	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
700598005618	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
700598005619	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
700598005620	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
700598005621	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598005622	Walker A/P-loop; other site
700598005623	ATP binding site [chemical binding]; other site
700598005624	Q-loop/lid; other site
700598005625	ABC transporter signature motif; other site
700598005626	Walker B; other site
700598005627	D-loop; other site
700598005628	H-loop/switch region; other site
700598005629	ABC transporter; Region: ABC_tran_2; pfam12848
700598005630	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700598005631	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598005632	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598005633	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598005634	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598005635	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598005636	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598005637	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598005638	FecR protein; Region: FecR; pfam04773
700598005639	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598005640	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598005641	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598005642	DNA binding residues [nucleotide binding]
700598005643	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598005644	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598005645	catalytic residues [active]
700598005646	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
700598005647	short chain dehydrogenase; Provisional; Region: PRK08263
700598005648	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598005649	NADP binding site [chemical binding]; other site
700598005650	active site
700598005651	steroid binding site; other site
700598005652	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598005653	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598005654	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598005655	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
700598005656	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598005657	NAD(P) binding site [chemical binding]; other site
700598005658	active site
700598005659	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598005660	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598005661	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
700598005662	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598005663	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
700598005664	dinuclear metal binding motif [ion binding]; other site
700598005665	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
700598005666	short chain dehydrogenase; Validated; Region: PRK08264
700598005667	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598005668	NAD(P) binding site [chemical binding]; other site
700598005669	active site
700598005670	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598005671	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598005672	Thioredoxin; Region: Thioredoxin_4; pfam13462
700598005673	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
700598005674	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
700598005675	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598005676	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
700598005677	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
700598005678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598005679	Response regulator receiver domain; Region: Response_reg; pfam00072
700598005680	active site
700598005681	phosphorylation site [posttranslational modification]
700598005682	intermolecular recognition site; other site
700598005683	dimerization interface [polypeptide binding]; other site
700598005684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598005685	ATP binding site [chemical binding]; other site
700598005686	Mg2+ binding site [ion binding]; other site
700598005687	G-X-G motif; other site
700598005688	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
700598005689	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
700598005690	putative dimer interface [polypeptide binding]; other site
700598005691	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
700598005692	BON domain; Region: BON; pfam04972
700598005693	BON domain; Region: BON; pfam04972
700598005694	BON domain; Region: BON; pfam04972
700598005695	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
700598005696	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700598005697	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700598005698	protein binding site [polypeptide binding]; other site
700598005699	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
700598005700	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700598005701	active site
700598005702	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
700598005703	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
700598005704	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
700598005705	catalytic residues [active]
700598005706	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
700598005707	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
700598005708	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
700598005709	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700598005710	E3 interaction surface; other site
700598005711	lipoyl attachment site [posttranslational modification]; other site
700598005712	e3 binding domain; Region: E3_binding; pfam02817
700598005713	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
700598005714	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
700598005715	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
700598005716	alpha subunit interface [polypeptide binding]; other site
700598005717	TPP binding site [chemical binding]; other site
700598005718	heterodimer interface [polypeptide binding]; other site
700598005719	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700598005720	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
700598005721	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
700598005722	tetramer interface [polypeptide binding]; other site
700598005723	TPP-binding site [chemical binding]; other site
700598005724	heterodimer interface [polypeptide binding]; other site
700598005725	phosphorylation loop region [posttranslational modification]
700598005726	acetyl-CoA synthetase; Provisional; Region: PRK04319
700598005727	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
700598005728	active site
700598005729	acyl-activating enzyme (AAE) consensus motif; other site
700598005730	putative CoA binding site [chemical binding]; other site
700598005731	AMP binding site [chemical binding]; other site
700598005732	Domain of unknown function (DUF4009); Region: DUF4009; pfam13193
700598005733	DNA polymerase IV (family X) [DNA replication, recombination, and repair]; Region: POL4; COG1796
700598005734	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
700598005735	active site
700598005736	primer binding site [nucleotide binding]; other site
700598005737	NTP  binding site [chemical binding]; other site
700598005738	metal binding triad [ion binding]; metal-binding site
700598005739	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
700598005740	Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387
700598005741	active site
700598005742	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
700598005743	BON domain; Region: BON; cl02771
700598005744	BON domain; Region: BON; pfam04972
700598005745	BON domain; Region: BON; pfam04972
700598005746	Ligase N family; Region: LIGANc; smart00532
700598005747	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
700598005748	nucleotide binding pocket [chemical binding]; other site
700598005749	K-X-D-G motif; other site
700598005750	catalytic site [active]
700598005751	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
700598005752	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
700598005753	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
700598005754	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
700598005755	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
700598005756	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
700598005757	ring oligomerisation interface [polypeptide binding]; other site
700598005758	ATP/Mg binding site [chemical binding]; other site
700598005759	stacking interactions; other site
700598005760	hinge regions; other site
700598005761	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
700598005762	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
700598005763	putative NAD(P) binding site [chemical binding]; other site
700598005764	putative substrate binding site [chemical binding]; other site
700598005765	catalytic Zn binding site [ion binding]; other site
700598005766	structural Zn binding site [ion binding]; other site
700598005767	PAS domain S-box; Region: sensory_box; TIGR00229
700598005768	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598005769	putative active site [active]
700598005770	heme pocket [chemical binding]; other site
700598005771	PAS domain S-box; Region: sensory_box; TIGR00229
700598005772	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598005773	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598005774	dimer interface [polypeptide binding]; other site
700598005775	phosphorylation site [posttranslational modification]
700598005776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598005777	ATP binding site [chemical binding]; other site
700598005778	Mg2+ binding site [ion binding]; other site
700598005779	G-X-G motif; other site
700598005780	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700598005781	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700598005782	Walker A/P-loop; other site
700598005783	ATP binding site [chemical binding]; other site
700598005784	Q-loop/lid; other site
700598005785	ABC transporter signature motif; other site
700598005786	Walker B; other site
700598005787	D-loop; other site
700598005788	H-loop/switch region; other site
700598005789	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
700598005790	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
700598005791	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
700598005792	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
700598005793	ABC-2 type transporter; Region: ABC2_membrane; cl17235
700598005794	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598005795	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
700598005796	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
700598005797	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
700598005798	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598005799	catalytic loop [active]
700598005800	iron binding site [ion binding]; other site
700598005801	4Fe-4S binding domain; Region: Fer4; pfam00037
700598005802	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
700598005803	[4Fe-4S] binding site [ion binding]; other site
700598005804	molybdopterin cofactor binding site; other site
700598005805	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
700598005806	molybdopterin cofactor binding site; other site
700598005807	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598005808	Ligand Binding Site [chemical binding]; other site
700598005809	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
700598005810	AAA domain; Region: AAA_33; pfam13671
700598005811	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
700598005812	active site
700598005813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
700598005814	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598005815	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598005816	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598005817	ligand binding site [chemical binding]; other site
700598005818	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
700598005819	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700598005820	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598005821	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
700598005822	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598005823	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598005824	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
700598005825	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
700598005826	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598005827	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598005828	Walker A/P-loop; other site
700598005829	ATP binding site [chemical binding]; other site
700598005830	Q-loop/lid; other site
700598005831	ABC transporter signature motif; other site
700598005832	Walker B; other site
700598005833	D-loop; other site
700598005834	H-loop/switch region; other site
700598005835	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598005836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598005837	active site
700598005838	phosphorylation site [posttranslational modification]
700598005839	intermolecular recognition site; other site
700598005840	dimerization interface [polypeptide binding]; other site
700598005841	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598005842	DNA binding residues [nucleotide binding]
700598005843	dimerization interface [polypeptide binding]; other site
700598005844	transcriptional activator RfaH; Region: RfaH; TIGR01955
700598005845	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
700598005846	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
700598005847	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
700598005848	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
700598005849	active site
700598005850	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
700598005851	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
700598005852	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
700598005853	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
700598005854	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
700598005855	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
700598005856	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700598005857	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
700598005858	Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843
700598005859	Condensation domain; Region: Condensation; pfam00668
700598005860	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005861	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005862	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005863	acyl-activating enzyme (AAE) consensus motif; other site
700598005864	AMP binding site [chemical binding]; other site
700598005865	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005866	Condensation domain; Region: Condensation; pfam00668
700598005867	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005868	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005869	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005870	acyl-activating enzyme (AAE) consensus motif; other site
700598005871	AMP binding site [chemical binding]; other site
700598005872	Condensation domain; Region: Condensation; pfam00668
700598005873	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
700598005874	Condensation domain; Region: Condensation; pfam00668
700598005875	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005876	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005877	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005878	acyl-activating enzyme (AAE) consensus motif; other site
700598005879	AMP binding site [chemical binding]; other site
700598005880	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005881	Condensation domain; Region: Condensation; pfam00668
700598005882	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005883	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005884	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
700598005885	acyl-activating enzyme (AAE) consensus motif; other site
700598005886	AMP binding site [chemical binding]; other site
700598005887	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005888	Condensation domain; Region: Condensation; pfam00668
700598005889	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005890	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005891	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
700598005892	acyl-activating enzyme (AAE) consensus motif; other site
700598005893	AMP binding site [chemical binding]; other site
700598005894	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005895	Condensation domain; Region: Condensation; pfam00668
700598005896	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005897	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005898	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
700598005899	acyl-activating enzyme (AAE) consensus motif; other site
700598005900	AMP binding site [chemical binding]; other site
700598005901	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005902	Condensation domain; Region: Condensation; pfam00668
700598005903	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005904	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005905	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005906	acyl-activating enzyme (AAE) consensus motif; other site
700598005907	AMP binding site [chemical binding]; other site
700598005908	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005909	Condensation domain; Region: Condensation; pfam00668
700598005910	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005911	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005912	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005913	acyl-activating enzyme (AAE) consensus motif; other site
700598005914	AMP binding site [chemical binding]; other site
700598005915	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005916	Condensation domain; Region: Condensation; pfam00668
700598005917	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005918	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005919	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005920	acyl-activating enzyme (AAE) consensus motif; other site
700598005921	AMP binding site [chemical binding]; other site
700598005922	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005923	Condensation domain; Region: Condensation; pfam00668
700598005924	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005925	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005926	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005927	acyl-activating enzyme (AAE) consensus motif; other site
700598005928	AMP binding site [chemical binding]; other site
700598005929	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005930	Condensation domain; Region: Condensation; pfam00668
700598005931	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005932	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005933	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005934	acyl-activating enzyme (AAE) consensus motif; other site
700598005935	AMP binding site [chemical binding]; other site
700598005936	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005937	Condensation domain; Region: Condensation; pfam00668
700598005938	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005939	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005940	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005941	acyl-activating enzyme (AAE) consensus motif; other site
700598005942	AMP binding site [chemical binding]; other site
700598005943	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005944	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
700598005945	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
700598005946	acyl-activating enzyme (AAE) consensus motif; other site
700598005947	active site
700598005948	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005949	Condensation domain; Region: Condensation; pfam00668
700598005950	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005951	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005952	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005953	acyl-activating enzyme (AAE) consensus motif; other site
700598005954	AMP binding site [chemical binding]; other site
700598005955	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005956	Condensation domain; Region: Condensation; pfam00668
700598005957	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005958	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005959	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
700598005960	acyl-activating enzyme (AAE) consensus motif; other site
700598005961	AMP binding site [chemical binding]; other site
700598005962	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005963	Condensation domain; Region: Condensation; pfam00668
700598005964	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005965	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005966	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005967	acyl-activating enzyme (AAE) consensus motif; other site
700598005968	AMP binding site [chemical binding]; other site
700598005969	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005970	Condensation domain; Region: Condensation; pfam00668
700598005971	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005972	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005973	acyl-activating enzyme (AAE) consensus motif; other site
700598005974	AMP binding site [chemical binding]; other site
700598005975	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005976	Condensation domain; Region: Condensation; pfam00668
700598005977	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700598005978	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700598005979	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700598005980	acyl-activating enzyme (AAE) consensus motif; other site
700598005981	AMP binding site [chemical binding]; other site
700598005982	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700598005983	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
700598005984	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
700598005985	dimer interface [polypeptide binding]; other site
700598005986	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598005987	catalytic residue [active]
700598005988	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
700598005989	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598005990	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598005991	DNA binding residues [nucleotide binding]
700598005992	diaminopimelate decarboxylase; Region: PLN02537
700598005993	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598005994	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598005995	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
700598005996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598005997	S-adenosylmethionine binding site [chemical binding]; other site
700598005998	Protein of unknown function (DUF616); Region: DUF616; pfam04765
700598005999	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598006000	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
700598006001	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598006002	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598006003	NAD(P) binding site [chemical binding]; other site
700598006004	active site
700598006005	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
700598006006	Peptidase family M1; Region: Peptidase_M1; pfam01433
700598006007	Zn binding site [ion binding]; other site
700598006008	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
700598006009	HEAT repeats; Region: HEAT_2; pfam13646
700598006010	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006011	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
700598006012	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
700598006013	active site
700598006014	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
700598006015	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700598006016	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598006017	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
700598006018	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598006019	catalytic residues [active]
700598006020	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598006021	SusD family; Region: SusD; pfam07980
700598006022	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598006023	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006024	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006025	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006026	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598006027	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598006028	FecR protein; Region: FecR; pfam04773
700598006029	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598006030	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006031	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598006032	DNA binding residues [nucleotide binding]
700598006033	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598006034	Two component regulator propeller; Region: Reg_prop; pfam07494
700598006035	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598006036	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598006037	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598006038	dimer interface [polypeptide binding]; other site
700598006039	phosphorylation site [posttranslational modification]
700598006040	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598006041	ATP binding site [chemical binding]; other site
700598006042	Mg2+ binding site [ion binding]; other site
700598006043	G-X-G motif; other site
700598006044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006045	Response regulator receiver domain; Region: Response_reg; pfam00072
700598006046	active site
700598006047	phosphorylation site [posttranslational modification]
700598006048	intermolecular recognition site; other site
700598006049	dimerization interface [polypeptide binding]; other site
700598006050	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598006051	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598006052	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598006053	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598006054	SusD family; Region: SusD; pfam07980
700598006055	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006056	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006057	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006058	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
700598006059	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598006060	Domain of unknown function (DUF718); Region: DUF718; pfam05336
700598006061	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
700598006062	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
700598006063	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
700598006064	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
700598006065	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
700598006066	putative sugar binding sites [chemical binding]; other site
700598006067	Q-X-W motif; other site
700598006068	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598006069	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598006070	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
700598006071	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598006072	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C_1; pfam13290
700598006073	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598006074	sugar binding site [chemical binding]; other site
700598006075	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
700598006076	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
700598006077	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
700598006078	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598006079	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598006080	SusD family; Region: SusD; pfam07980
700598006081	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006082	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006083	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006084	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598006085	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598006086	SusD family; Region: SusD; pfam07980
700598006087	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006088	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006089	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006090	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598006091	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
700598006092	PA14 domain; Region: PA14; cl08459
700598006093	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
700598006094	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
700598006095	putative active site [active]
700598006096	putative catalytic site [active]
700598006097	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598006098	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598006099	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598006100	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700598006101	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598006102	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700598006103	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
700598006104	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700598006105	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700598006106	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598006107	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
700598006108	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598006109	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598006110	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
700598006111	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598006112	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598006113	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598006114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598006115	dimer interface [polypeptide binding]; other site
700598006116	phosphorylation site [posttranslational modification]
700598006117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598006118	ATP binding site [chemical binding]; other site
700598006119	Mg2+ binding site [ion binding]; other site
700598006120	G-X-G motif; other site
700598006121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006122	Response regulator receiver domain; Region: Response_reg; pfam00072
700598006123	active site
700598006124	phosphorylation site [posttranslational modification]
700598006125	intermolecular recognition site; other site
700598006126	dimerization interface [polypeptide binding]; other site
700598006127	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598006128	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598006129	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598006130	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598006131	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598006132	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598006133	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
700598006134	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598006135	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598006136	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
700598006137	Ligand binding site; other site
700598006138	Putative Catalytic site; other site
700598006139	DXD motif; other site
700598006140	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
700598006141	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700598006142	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598006143	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
700598006144	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598006145	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598006146	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598006147	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006148	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006149	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006150	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598006151	FecR protein; Region: FecR; pfam04773
700598006152	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598006153	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006154	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598006155	DNA binding residues [nucleotide binding]
700598006156	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
700598006157	RteC protein; Region: RteC; pfam09357
700598006158	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598006159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006160	active site
700598006161	phosphorylation site [posttranslational modification]
700598006162	intermolecular recognition site; other site
700598006163	dimerization interface [polypeptide binding]; other site
700598006164	LytTr DNA-binding domain; Region: LytTR; smart00850
700598006165	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598006166	Histidine kinase; Region: His_kinase; pfam06580
700598006167	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700598006168	Carboxylesterase family; Region: COesterase; pfam00135
700598006169	substrate binding pocket [chemical binding]; other site
700598006170	catalytic triad [active]
700598006171	beta-D-glucuronidase; Provisional; Region: PRK10150
700598006172	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598006173	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598006174	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598006175	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
700598006176	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
700598006177	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
700598006178	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598006179	SusD family; Region: SusD; pfam07980
700598006180	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598006181	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006182	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006183	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006184	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598006185	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598006186	FecR protein; Region: FecR; pfam04773
700598006187	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598006188	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006189	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598006190	DNA binding residues [nucleotide binding]
700598006191	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598006192	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
700598006193	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
700598006194	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
700598006195	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598006196	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
700598006197	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
700598006198	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
700598006199	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
700598006200	putative active site [active]
700598006201	putative catalytic site [active]
700598006202	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598006203	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
700598006204	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
700598006205	Putative esterase; Region: Esterase; pfam00756
700598006206	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598006207	SusD family; Region: SusD; pfam07980
700598006208	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006209	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006210	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006211	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
700598006212	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
700598006213	active site
700598006214	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
700598006215	ligand binding site [chemical binding]; other site
700598006216	metal binding site [ion binding]; metal-binding site
700598006217	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
700598006218	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598006219	SusD family; Region: SusD; pfam07980
700598006220	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006221	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598006222	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598006223	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598006224	SusD family; Region: SusD; pfam07980
700598006225	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006226	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006227	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006228	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
700598006229	substrate binding site [chemical binding]; other site
700598006230	active site
700598006231	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
700598006232	ligand binding site [chemical binding]; other site
700598006233	metal binding site [ion binding]; metal-binding site
700598006234	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
700598006235	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
700598006236	Putative esterase; Region: Esterase; pfam00756
700598006237	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
700598006238	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
700598006239	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
700598006240	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
700598006241	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
700598006242	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
700598006243	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700598006244	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700598006245	PA14 domain; Region: PA14; cl08459
700598006246	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700598006247	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598006248	Two component regulator propeller; Region: Reg_prop; pfam07494
700598006249	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598006250	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598006251	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598006252	dimer interface [polypeptide binding]; other site
700598006253	phosphorylation site [posttranslational modification]
700598006254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598006255	ATP binding site [chemical binding]; other site
700598006256	Mg2+ binding site [ion binding]; other site
700598006257	G-X-G motif; other site
700598006258	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598006259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006260	active site
700598006261	phosphorylation site [posttranslational modification]
700598006262	intermolecular recognition site; other site
700598006263	dimerization interface [polypeptide binding]; other site
700598006264	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598006265	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598006266	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
700598006267	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598006268	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598006269	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
700598006270	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598006271	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
700598006272	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598006273	Outer membrane efflux protein; Region: OEP; pfam02321
700598006274	Outer membrane efflux protein; Region: OEP; pfam02321
700598006275	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598006276	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598006277	DNA binding site [nucleotide binding]
700598006278	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700598006279	M28 Zn-Peptidases; Region: M28_like_4; cd08015
700598006280	Peptidase family M28; Region: Peptidase_M28; pfam04389
700598006281	metal binding site [ion binding]; metal-binding site
700598006282	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598006283	GLPGLI family protein; Region: GLPGLI; TIGR01200
700598006284	Histidine kinase; Region: His_kinase; pfam06580
700598006285	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598006286	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006287	active site
700598006288	phosphorylation site [posttranslational modification]
700598006289	intermolecular recognition site; other site
700598006290	dimerization interface [polypeptide binding]; other site
700598006291	LytTr DNA-binding domain; Region: LytTR; smart00850
700598006292	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
700598006293	putative dimer interface [polypeptide binding]; other site
700598006294	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598006295	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598006296	active site
700598006297	catalytic tetrad [active]
700598006298	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598006299	PQQ-like domain; Region: PQQ_2; pfam13360
700598006300	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
700598006301	putative hydrophobic ligand binding site [chemical binding]; other site
700598006302	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598006303	dimerization interface [polypeptide binding]; other site
700598006304	putative DNA binding site [nucleotide binding]; other site
700598006305	putative Zn2+ binding site [ion binding]; other site
700598006306	Cupin domain; Region: Cupin_2; pfam07883
700598006307	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598006308	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598006309	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700598006310	Predicted peptidase [General function prediction only]; Region: COG4099
700598006311	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598006312	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
700598006313	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598006314	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598006315	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
700598006316	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
700598006317	putative NAD(P) binding site [chemical binding]; other site
700598006318	SnoaL-like domain; Region: SnoaL_4; pfam13577
700598006319	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
700598006320	conserved cys residue [active]
700598006321	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
700598006322	Acyltransferase family; Region: Acyl_transf_3; pfam01757
700598006323	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
700598006324	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598006325	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598006326	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006327	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598006328	DNA binding residues [nucleotide binding]
700598006329	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598006330	FecR protein; Region: FecR; pfam04773
700598006331	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006332	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006333	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598006334	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598006335	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598006336	SusD family; Region: SusD; pfam07980
700598006337	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598006338	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574
700598006339	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
700598006340	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598006341	adenosine deaminase-related growth factor; Region: adm_rel; TIGR01431
700598006342	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598006343	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598006344	active site
700598006345	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598006346	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598006347	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598006348	PAS domain; Region: PAS_9; pfam13426
700598006349	putative active site [active]
700598006350	heme pocket [chemical binding]; other site
700598006351	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598006352	dimer interface [polypeptide binding]; other site
700598006353	phosphorylation site [posttranslational modification]
700598006354	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598006355	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006356	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
700598006357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598006358	NAD(P) binding site [chemical binding]; other site
700598006359	active site
700598006360	transketolase; Reviewed; Region: PRK05899
700598006361	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
700598006362	TPP-binding site [chemical binding]; other site
700598006363	dimer interface [polypeptide binding]; other site
700598006364	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700598006365	PYR/PP interface [polypeptide binding]; other site
700598006366	dimer interface [polypeptide binding]; other site
700598006367	TPP binding site [chemical binding]; other site
700598006368	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700598006369	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598006370	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598006371	ligand binding site [chemical binding]; other site
700598006372	flexible hinge region; other site
700598006373	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
700598006374	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598006375	putative NAD(P) binding site [chemical binding]; other site
700598006376	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
700598006377	Predicted acyl esterases [General function prediction only]; Region: COG2936
700598006378	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598006379	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
700598006380	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006381	YCII-related domain; Region: YCII; cl00999
700598006382	RibD C-terminal domain; Region: RibD_C; cl17279
700598006383	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
700598006384	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598006385	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598006386	ligand binding site [chemical binding]; other site
700598006387	Pectate lyase; Region: Pec_lyase_C; cl01593
700598006388	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598006389	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598006390	DNA binding site [nucleotide binding]
700598006391	domain linker motif; other site
700598006392	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598006393	dimerization interface [polypeptide binding]; other site
700598006394	ligand binding site [chemical binding]; other site
700598006395	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
700598006396	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
700598006397	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653
700598006398	Active_site [active]
700598006399	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598006400	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
700598006401	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598006402	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
700598006403	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
700598006404	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700598006405	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
700598006406	Lamin Tail Domain; Region: LTD; pfam00932
700598006407	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
700598006408	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598006409	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598006410	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
700598006411	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700598006412	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598006413	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006414	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598006415	DNA binding residues [nucleotide binding]
700598006416	FecR protein; Region: FecR; pfam04773
700598006417	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006418	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006419	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006420	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598006421	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
700598006422	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598006423	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598006424	Cupin domain; Region: Cupin_2; cl17218
700598006425	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
700598006426	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
700598006427	active site
700598006428	catalytic triad [active]
700598006429	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
700598006430	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598006431	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598006432	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598006433	NAD(P) binding site [chemical binding]; other site
700598006434	active site
700598006435	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
700598006436	glycerate dehydrogenase; Provisional; Region: PRK06487
700598006437	putative ligand binding site [chemical binding]; other site
700598006438	putative NAD binding site [chemical binding]; other site
700598006439	catalytic site [active]
700598006440	dihydroorotase; Validated; Region: pyrC; PRK09357
700598006441	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598006442	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
700598006443	active site
700598006444	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
700598006445	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598006446	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
700598006447	Ligand binding site; other site
700598006448	Putative Catalytic site; other site
700598006449	DXD motif; other site
700598006450	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
700598006451	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598006452	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
700598006453	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
700598006454	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
700598006455	dimer interface [polypeptide binding]; other site
700598006456	active site
700598006457	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
700598006458	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
700598006459	Substrate binding site; other site
700598006460	Mg++ binding site; other site
700598006461	metal-binding site
700598006462	Mg++ binding site; other site
700598006463	metal-binding site
700598006464	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
700598006465	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598006466	active site
700598006467	motif I; other site
700598006468	motif II; other site
700598006469	Bacterial PH domain; Region: DUF304; pfam03703
700598006470	Short C-terminal domain; Region: SHOCT; pfam09851
700598006471	GTP-binding protein LepA; Provisional; Region: PRK05433
700598006472	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
700598006473	G1 box; other site
700598006474	putative GEF interaction site [polypeptide binding]; other site
700598006475	GTP/Mg2+ binding site [chemical binding]; other site
700598006476	Switch I region; other site
700598006477	G2 box; other site
700598006478	G3 box; other site
700598006479	Switch II region; other site
700598006480	G4 box; other site
700598006481	G5 box; other site
700598006482	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
700598006483	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
700598006484	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
700598006485	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006486	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
700598006487	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598006488	DNA binding residues [nucleotide binding]
700598006489	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006490	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
700598006491	N-terminal plug; other site
700598006492	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
700598006493	ligand-binding site [chemical binding]; other site
700598006494	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
700598006495	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
700598006496	active site
700598006497	4-alpha-glucanotransferase; Region: PLN02950
700598006498	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
700598006499	starch-binding site 2 [chemical binding]; other site
700598006500	starch-binding site 1 [chemical binding]; other site
700598006501	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
700598006502	starch-binding site 2 [chemical binding]; other site
700598006503	starch-binding site 1 [chemical binding]; other site
700598006504	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
700598006505	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
700598006506	Gram-negative bacterial tonB protein; Region: TonB; cl10048
700598006507	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
700598006508	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
700598006509	dimer interface [polypeptide binding]; other site
700598006510	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
700598006511	active site
700598006512	Fe binding site [ion binding]; other site
700598006513	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
700598006514	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700598006515	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598006516	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598006517	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598006518	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598006519	Protein export membrane protein; Region: SecD_SecF; cl14618
700598006520	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
700598006521	AIR carboxylase; Region: AIRC; pfam00731
700598006522	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
700598006523	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
700598006524	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
700598006525	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
700598006526	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
700598006527	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700598006528	hydroxyglutarate oxidase; Provisional; Region: PRK11728
700598006529	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
700598006530	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
700598006531	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
700598006532	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
700598006533	dimer interface [polypeptide binding]; other site
700598006534	NADP binding site [chemical binding]; other site
700598006535	catalytic residues [active]
700598006536	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
700598006537	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
700598006538	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598006539	FeS/SAM binding site; other site
700598006540	TRAM domain; Region: TRAM; cl01282
700598006541	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
700598006542	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
700598006543	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700598006544	Domain of unknown function (DUF4295); Region: DUF4295; pfam14128
700598006545	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
700598006546	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
700598006547	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
700598006548	polyphosphate kinase; Provisional; Region: PRK05443
700598006549	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
700598006550	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
700598006551	domain interface [polypeptide binding]; other site
700598006552	active site
700598006553	catalytic site [active]
700598006554	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
700598006555	putative active site [active]
700598006556	catalytic site [active]
700598006557	exopolyphosphatase; Region: exo_poly_only; TIGR03706
700598006558	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
700598006559	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
700598006560	oligomerization interface [polypeptide binding]; other site
700598006561	active site
700598006562	metal binding site [ion binding]; metal-binding site
700598006563	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
700598006564	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598006565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006566	active site
700598006567	phosphorylation site [posttranslational modification]
700598006568	intermolecular recognition site; other site
700598006569	dimerization interface [polypeptide binding]; other site
700598006570	LytTr DNA-binding domain; Region: LytTR; smart00850
700598006571	Histidine kinase; Region: His_kinase; pfam06580
700598006572	DoxX; Region: DoxX; pfam07681
700598006573	potential frameshift: common BLAST hit: gi|365960894|ref|YP_004942461.1| Rhs family protein
700598006574	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
700598006575	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598006576	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
700598006577	RHS Repeat; Region: RHS_repeat; cl11982
700598006578	RHS Repeat; Region: RHS_repeat; pfam05593
700598006579	RHS Repeat; Region: RHS_repeat; pfam05593
700598006580	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
700598006581	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
700598006582	Protein of unknown function (DUF877); Region: DUF877; pfam05943
700598006583	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
700598006584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598006585	Walker A motif; other site
700598006586	ATP binding site [chemical binding]; other site
700598006587	Walker B motif; other site
700598006588	arginine finger; other site
700598006589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598006590	Walker A motif; other site
700598006591	ATP binding site [chemical binding]; other site
700598006592	Walker B motif; other site
700598006593	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
700598006594	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598006595	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598006596	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598006597	NlpC/P60 family; Region: NLPC_P60; pfam00877
700598006598	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
700598006599	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700598006600	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
700598006601	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
700598006602	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006603	Inward rectifier potassium channel; Region: IRK; pfam01007
700598006604	Uncharacterized conserved protein [Function unknown]; Region: COG1434
700598006605	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
700598006606	putative active site [active]
700598006607	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
700598006608	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
700598006609	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
700598006610	putative active site [active]
700598006611	putative substrate binding site [chemical binding]; other site
700598006612	putative cosubstrate binding site; other site
700598006613	catalytic site [active]
700598006614	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006615	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598006616	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
700598006617	N-terminal plug; other site
700598006618	ligand-binding site [chemical binding]; other site
700598006619	fec operon regulator FecR; Reviewed; Region: PRK09774
700598006620	FecR protein; Region: FecR; pfam04773
700598006621	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598006622	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006623	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598006624	DNA binding residues [nucleotide binding]
700598006625	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598006626	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598006627	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
700598006628	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700598006629	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
700598006630	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598006631	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598006632	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598006633	putative active site [active]
700598006634	heme pocket [chemical binding]; other site
700598006635	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598006636	putative active site [active]
700598006637	heme pocket [chemical binding]; other site
700598006638	PAS domain; Region: PAS_9; pfam13426
700598006639	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598006640	putative active site [active]
700598006641	heme pocket [chemical binding]; other site
700598006642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598006643	dimer interface [polypeptide binding]; other site
700598006644	phosphorylation site [posttranslational modification]
700598006645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598006646	ATP binding site [chemical binding]; other site
700598006647	Mg2+ binding site [ion binding]; other site
700598006648	G-X-G motif; other site
700598006649	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
700598006650	elongation factor G; Reviewed; Region: PRK12740
700598006651	G1 box; other site
700598006652	putative GEF interaction site [polypeptide binding]; other site
700598006653	GTP/Mg2+ binding site [chemical binding]; other site
700598006654	Switch I region; other site
700598006655	G2 box; other site
700598006656	G3 box; other site
700598006657	Switch II region; other site
700598006658	G4 box; other site
700598006659	G5 box; other site
700598006660	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
700598006661	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
700598006662	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
700598006663	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
700598006664	DNA primase, catalytic core; Region: dnaG; TIGR01391
700598006665	CHC2 zinc finger; Region: zf-CHC2; pfam01807
700598006666	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
700598006667	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
700598006668	active site
700598006669	metal binding site [ion binding]; metal-binding site
700598006670	interdomain interaction site; other site
700598006671	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
700598006672	amidase catalytic site [active]
700598006673	Zn binding residues [ion binding]; other site
700598006674	substrate binding site [chemical binding]; other site
700598006675	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
700598006676	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
700598006677	putative sugar binding sites [chemical binding]; other site
700598006678	Q-X-W motif; other site
700598006679	Peptidase family M48; Region: Peptidase_M48; pfam01435
700598006680	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
700598006681	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
700598006682	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598006683	S-adenosylmethionine binding site [chemical binding]; other site
700598006684	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
700598006685	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
700598006686	RNase E interface [polypeptide binding]; other site
700598006687	trimer interface [polypeptide binding]; other site
700598006688	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
700598006689	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
700598006690	RNase E interface [polypeptide binding]; other site
700598006691	trimer interface [polypeptide binding]; other site
700598006692	active site
700598006693	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
700598006694	putative nucleic acid binding region [nucleotide binding]; other site
700598006695	G-X-X-G motif; other site
700598006696	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
700598006697	RNA binding site [nucleotide binding]; other site
700598006698	domain interface; other site
700598006699	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
700598006700	16S/18S rRNA binding site [nucleotide binding]; other site
700598006701	S13e-L30e interaction site [polypeptide binding]; other site
700598006702	25S rRNA binding site [nucleotide binding]; other site
700598006703	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598006704	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598006705	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
700598006706	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
700598006707	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
700598006708	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700598006709	Walker A/P-loop; other site
700598006710	ATP binding site [chemical binding]; other site
700598006711	Q-loop/lid; other site
700598006712	ABC transporter signature motif; other site
700598006713	Walker B; other site
700598006714	D-loop; other site
700598006715	H-loop/switch region; other site
700598006716	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006717	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
700598006718	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
700598006719	N-terminal plug; other site
700598006720	ligand-binding site [chemical binding]; other site
700598006721	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700598006722	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700598006723	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
700598006724	putative dimerization interface [polypeptide binding]; other site
700598006725	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
700598006726	Trehalose utilisation; Region: ThuA; pfam06283
700598006727	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
700598006728	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
700598006729	TrkA-N domain; Region: TrkA_N; pfam02254
700598006730	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
700598006731	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
700598006732	inhibitor binding site; inhibition site
700598006733	active site
700598006734	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
700598006735	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
700598006736	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
700598006737	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
700598006738	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598006739	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598006740	SusD family; Region: SusD; pfam07980
700598006741	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006742	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006743	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006744	FecR protein; Region: FecR; pfam04773
700598006745	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598006746	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598006747	DNA binding residues [nucleotide binding]
700598006748	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
700598006749	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006750	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006751	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006752	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
700598006753	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598006754	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598006755	Pirin-related protein [General function prediction only]; Region: COG1741
700598006756	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
700598006757	putative active site [active]
700598006758	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
700598006759	DinB superfamily; Region: DinB_2; pfam12867
700598006760	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598006761	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006762	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598006763	DNA binding residues [nucleotide binding]
700598006764	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598006765	FecR protein; Region: FecR; pfam04773
700598006766	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598006767	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006768	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006769	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006770	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598006771	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598006772	SusD family; Region: SusD; pfam07980
700598006773	Family description; Region: VCBS; pfam13517
700598006774	Family description; Region: VCBS; pfam13517
700598006775	Family description; Region: VCBS; pfam13517
700598006776	Family description; Region: VCBS; pfam13517
700598006777	Family description; Region: VCBS; pfam13517
700598006778	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
700598006779	Family description; Region: VCBS; pfam13517
700598006780	Family description; Region: VCBS; pfam13517
700598006781	Family description; Region: VCBS; pfam13517
700598006782	Family description; Region: VCBS; pfam13517
700598006783	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
700598006784	active site
700598006785	Domain of unknown function (DUF386); Region: DUF386; cl01047
700598006786	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
700598006787	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700598006788	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700598006789	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
700598006790	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
700598006791	substrate binding site [chemical binding]; other site
700598006792	ligand binding site [chemical binding]; other site
700598006793	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
700598006794	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
700598006795	substrate binding site [chemical binding]; other site
700598006796	2-isopropylmalate synthase; Validated; Region: PRK00915
700598006797	Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945
700598006798	active site
700598006799	catalytic residues [active]
700598006800	metal binding site [ion binding]; metal-binding site
700598006801	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
700598006802	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
700598006803	four helix bundle protein; Region: TIGR02436
700598006804	tartrate dehydrogenase; Region: TTC; TIGR02089
700598006805	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
700598006806	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
700598006807	fructuronate transporter; Provisional; Region: PRK10034; cl15264
700598006808	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
700598006809	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700598006810	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
700598006811	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
700598006812	metal binding site [ion binding]; metal-binding site
700598006813	substrate binding pocket [chemical binding]; other site
700598006814	Methylamine utilisation protein MauE; Region: MauE; pfam07291
700598006815	HTH domain; Region: HTH_11; cl17392
700598006816	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700598006817	active site
700598006818	ATP binding site [chemical binding]; other site
700598006819	Protein kinase domain; Region: Pkinase; pfam00069
700598006820	substrate binding site [chemical binding]; other site
700598006821	activation loop (A-loop); other site
700598006822	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
700598006823	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434
700598006824	active site
700598006825	zinc binding site [ion binding]; other site
700598006826	Protein phosphatase 2A homologues, catalytic domain; Region: PP2Ac; smart00156
700598006827	Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425
700598006828	active site
700598006829	metal binding site [ion binding]; metal-binding site
700598006830	Domain of unknown function (DUF4221); Region: DUF4221; pfam13970
700598006831	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
700598006832	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598006833	Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425
700598006834	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598006835	active site
700598006836	metal binding site [ion binding]; metal-binding site
700598006837	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598006838	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598006839	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598006840	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006841	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006842	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598006843	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598006844	FecR protein; Region: FecR; pfam04773
700598006845	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598006846	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598006847	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598006848	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
700598006849	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700598006850	phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351
700598006851	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598006852	motif II; other site
700598006853	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700598006854	Zn2+ binding site [ion binding]; other site
700598006855	Mg2+ binding site [ion binding]; other site
700598006856	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
700598006857	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598006858	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006859	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006860	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598006861	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700598006862	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598006863	non-specific DNA binding site [nucleotide binding]; other site
700598006864	salt bridge; other site
700598006865	sequence-specific DNA binding site [nucleotide binding]; other site
700598006866	Cupin domain; Region: Cupin_2; pfam07883
700598006867	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
700598006868	active site
700598006869	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700598006870	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
700598006871	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
700598006872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
700598006873	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
700598006874	active site
700598006875	catalytic triad [active]
700598006876	oxyanion hole [active]
700598006877	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700598006878	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
700598006879	active site
700598006880	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
700598006881	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
700598006882	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
700598006883	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598006884	FecR protein; Region: FecR; pfam04773
700598006885	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598006886	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598006887	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598006888	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598006889	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598006890	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598006891	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598006892	PGAP1-like protein; Region: PGAP1; pfam07819
700598006893	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006894	active site
700598006895	phosphorylation site [posttranslational modification]
700598006896	intermolecular recognition site; other site
700598006897	PAS fold; Region: PAS_3; pfam08447
700598006898	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598006899	Histidine kinase; Region: HisKA_3; pfam07730
700598006900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598006901	ATP binding site [chemical binding]; other site
700598006902	Mg2+ binding site [ion binding]; other site
700598006903	G-X-G motif; other site
700598006904	Response regulator receiver domain; Region: Response_reg; pfam00072
700598006905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006906	active site
700598006907	phosphorylation site [posttranslational modification]
700598006908	intermolecular recognition site; other site
700598006909	dimerization interface [polypeptide binding]; other site
700598006910	Response regulator receiver domain; Region: Response_reg; pfam00072
700598006911	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006912	active site
700598006913	phosphorylation site [posttranslational modification]
700598006914	intermolecular recognition site; other site
700598006915	dimerization interface [polypeptide binding]; other site
700598006916	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598006917	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598006918	putative active site [active]
700598006919	heme pocket [chemical binding]; other site
700598006920	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598006921	dimer interface [polypeptide binding]; other site
700598006922	phosphorylation site [posttranslational modification]
700598006923	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598006924	ATP binding site [chemical binding]; other site
700598006925	Mg2+ binding site [ion binding]; other site
700598006926	G-X-G motif; other site
700598006927	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
700598006928	CheB methylesterase; Region: CheB_methylest; pfam01339
700598006929	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
700598006930	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
700598006931	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
700598006932	Nitrate and nitrite sensing; Region: NIT; pfam08376
700598006933	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598006934	dimerization interface [polypeptide binding]; other site
700598006935	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700598006936	GAF domain; Region: GAF; pfam01590
700598006937	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598006938	dimer interface [polypeptide binding]; other site
700598006939	phosphorylation site [posttranslational modification]
700598006940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598006941	ATP binding site [chemical binding]; other site
700598006942	Mg2+ binding site [ion binding]; other site
700598006943	G-X-G motif; other site
700598006944	Response regulator receiver domain; Region: Response_reg; pfam00072
700598006945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006946	active site
700598006947	phosphorylation site [posttranslational modification]
700598006948	intermolecular recognition site; other site
700598006949	dimerization interface [polypeptide binding]; other site
700598006950	Response regulator receiver domain; Region: Response_reg; pfam00072
700598006951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006952	active site
700598006953	phosphorylation site [posttranslational modification]
700598006954	intermolecular recognition site; other site
700598006955	dimerization interface [polypeptide binding]; other site
700598006956	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598006957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006958	active site
700598006959	phosphorylation site [posttranslational modification]
700598006960	intermolecular recognition site; other site
700598006961	dimerization interface [polypeptide binding]; other site
700598006962	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598006963	Two component regulator propeller; Region: Reg_prop; pfam07494
700598006964	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598006965	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598006966	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598006967	dimer interface [polypeptide binding]; other site
700598006968	phosphorylation site [posttranslational modification]
700598006969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598006970	ATP binding site [chemical binding]; other site
700598006971	Mg2+ binding site [ion binding]; other site
700598006972	G-X-G motif; other site
700598006973	Response regulator receiver domain; Region: Response_reg; pfam00072
700598006974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006975	active site
700598006976	phosphorylation site [posttranslational modification]
700598006977	intermolecular recognition site; other site
700598006978	dimerization interface [polypeptide binding]; other site
700598006979	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598006980	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598006981	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
700598006982	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
700598006983	putative active site [active]
700598006984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006985	Response regulator receiver domain; Region: Response_reg; pfam00072
700598006986	active site
700598006987	phosphorylation site [posttranslational modification]
700598006988	intermolecular recognition site; other site
700598006989	dimerization interface [polypeptide binding]; other site
700598006990	Response regulator receiver domain; Region: Response_reg; pfam00072
700598006991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598006992	active site
700598006993	phosphorylation site [posttranslational modification]
700598006994	intermolecular recognition site; other site
700598006995	dimerization interface [polypeptide binding]; other site
700598006996	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598006997	dimer interface [polypeptide binding]; other site
700598006998	phosphorylation site [posttranslational modification]
700598006999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007000	ATP binding site [chemical binding]; other site
700598007001	Mg2+ binding site [ion binding]; other site
700598007002	G-X-G motif; other site
700598007003	CHASE3 domain; Region: CHASE3; pfam05227
700598007004	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598007005	dimerization interface [polypeptide binding]; other site
700598007006	GAF domain; Region: GAF_2; pfam13185
700598007007	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
700598007008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598007009	dimer interface [polypeptide binding]; other site
700598007010	phosphorylation site [posttranslational modification]
700598007011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007012	ATP binding site [chemical binding]; other site
700598007013	Mg2+ binding site [ion binding]; other site
700598007014	G-X-G motif; other site
700598007015	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598007016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007017	active site
700598007018	phosphorylation site [posttranslational modification]
700598007019	intermolecular recognition site; other site
700598007020	dimerization interface [polypeptide binding]; other site
700598007021	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598007022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007023	active site
700598007024	phosphorylation site [posttranslational modification]
700598007025	intermolecular recognition site; other site
700598007026	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598007027	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007028	active site
700598007029	phosphorylation site [posttranslational modification]
700598007030	intermolecular recognition site; other site
700598007031	dimerization interface [polypeptide binding]; other site
700598007032	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
700598007033	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
700598007034	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
700598007035	CheB methylesterase; Region: CheB_methylest; pfam01339
700598007036	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700598007037	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
700598007038	putative active site [active]
700598007039	putative metal binding site [ion binding]; other site
700598007040	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
700598007041	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
700598007042	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
700598007043	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598007044	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
700598007045	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
700598007046	N-terminal plug; other site
700598007047	ligand-binding site [chemical binding]; other site
700598007048	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
700598007049	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
700598007050	active site
700598007051	iron coordination sites [ion binding]; other site
700598007052	substrate binding pocket [chemical binding]; other site
700598007053	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
700598007054	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598007055	catalytic residue [active]
700598007056	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
700598007057	IucA / IucC family; Region: IucA_IucC; pfam04183
700598007058	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
700598007059	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
700598007060	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
700598007061	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
700598007062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598007063	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
700598007064	IucA / IucC family; Region: IucA_IucC; pfam04183
700598007065	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
700598007066	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139
700598007067	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
700598007068	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
700598007069	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
700598007070	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700598007071	active site
700598007072	CoA binding site [chemical binding]; other site
700598007073	AMP binding site [chemical binding]; other site
700598007074	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598007075	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598007076	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598007077	DNA binding residues [nucleotide binding]
700598007078	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598007079	FecR protein; Region: FecR; pfam04773
700598007080	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598007081	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007082	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007083	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598007084	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
700598007085	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007086	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598007087	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598007088	SusD family; Region: SusD; pfam07980
700598007089	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598007090	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598007091	catalytic residues [active]
700598007092	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
700598007093	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
700598007094	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007095	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007096	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007097	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598007098	Tic20-like protein; Region: Tic20; pfam09685
700598007099	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598007100	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598007101	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598007102	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598007103	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598007104	Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
700598007105	active site
700598007106	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598007107	Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519
700598007108	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
700598007109	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598007110	binding surface
700598007111	TPR motif; other site
700598007112	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598007113	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598007114	ligand binding site [chemical binding]; other site
700598007115	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
700598007116	Domain of unknown function (DUF4302); Region: DUF4302; pfam14135
700598007117	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598007118	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598007119	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007120	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007121	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598007122	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598007123	FecR protein; Region: FecR; pfam04773
700598007124	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598007125	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598007126	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598007127	DNA binding residues [nucleotide binding]
700598007128	Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112
700598007129	Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113
700598007130	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598007131	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598007132	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598007133	binding surface
700598007134	TPR motif; other site
700598007135	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598007136	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
700598007137	catalytic site [active]
700598007138	Asp-box motif; other site
700598007139	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598007140	SusD family; Region: SusD; pfam07980
700598007141	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007142	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007143	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598007144	LytTr DNA-binding domain; Region: LytTR; smart00850
700598007145	Haem-binding domain; Region: Haem_bd; pfam14376
700598007146	lysozyme inhibitor; Provisional; Region: PRK11372
700598007147	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598007148	Two component regulator propeller; Region: Reg_prop; pfam07494
700598007149	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598007150	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598007151	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598007152	dimer interface [polypeptide binding]; other site
700598007153	phosphorylation site [posttranslational modification]
700598007154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007155	ATP binding site [chemical binding]; other site
700598007156	Mg2+ binding site [ion binding]; other site
700598007157	G-X-G motif; other site
700598007158	Response regulator receiver domain; Region: Response_reg; pfam00072
700598007159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007160	active site
700598007161	phosphorylation site [posttranslational modification]
700598007162	intermolecular recognition site; other site
700598007163	dimerization interface [polypeptide binding]; other site
700598007164	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598007165	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007166	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007167	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007168	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598007169	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598007170	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598007171	SusD family; Region: SusD; pfam07980
700598007172	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598007173	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598007174	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598007175	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598007176	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598007177	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007178	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598007179	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598007180	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598007181	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598007182	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598007183	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
700598007184	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
700598007185	putative hydrophobic ligand binding site [chemical binding]; other site
700598007186	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598007187	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598007188	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007189	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007190	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598007191	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
700598007192	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
700598007193	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
700598007194	substrate binding site [chemical binding]; other site
700598007195	active site
700598007196	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
700598007197	putative hydrophobic ligand binding site [chemical binding]; other site
700598007198	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
700598007199	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
700598007200	conserved cys residue [active]
700598007201	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598007202	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598007203	active site
700598007204	metal binding site [ion binding]; metal-binding site
700598007205	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598007206	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598007207	ligand binding site [chemical binding]; other site
700598007208	flexible hinge region; other site
700598007209	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
700598007210	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
700598007211	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
700598007212	active site pocket [active]
700598007213	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
700598007214	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
700598007215	Sodium Bile acid symporter family; Region: SBF; pfam01758
700598007216	galactonate dehydratase; Provisional; Region: PRK14017
700598007217	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
700598007218	active site pocket [active]
700598007219	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
700598007220	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
700598007221	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
700598007222	N- and C-terminal domain interface [polypeptide binding]; other site
700598007223	active site
700598007224	catalytic site [active]
700598007225	metal binding site [ion binding]; metal-binding site
700598007226	carbohydrate binding site [chemical binding]; other site
700598007227	ATP binding site [chemical binding]; other site
700598007228	Cupin domain; Region: Cupin_2; cl17218
700598007229	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598007230	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007231	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007232	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007233	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007234	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598007235	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007236	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598007237	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598007238	dihydroxy-acid dehydratase; Validated; Region: PRK06131
700598007239	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
700598007240	active site
700598007241	Mn binding site [ion binding]; other site
700598007242	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
700598007243	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
700598007244	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
700598007245	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
700598007246	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
700598007247	active site
700598007248	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
700598007249	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700598007250	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700598007251	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598007252	TIGR03118 family protein; Region: PEPCTERM_chp_1
700598007253	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
700598007254	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
700598007255	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
700598007256	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
700598007257	ring oligomerisation interface [polypeptide binding]; other site
700598007258	ATP/Mg binding site [chemical binding]; other site
700598007259	stacking interactions; other site
700598007260	hinge regions; other site
700598007261	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
700598007262	oligomerisation interface [polypeptide binding]; other site
700598007263	mobile loop; other site
700598007264	roof hairpin; other site
700598007265	Phosphoesterase family; Region: Phosphoesterase; pfam04185
700598007266	Phosphoesterase family; Region: Phosphoesterase; pfam04185
700598007267	Domain of unknown function (DUF756); Region: DUF756; pfam05506
700598007268	Domain of unknown function (DUF756); Region: DUF756; pfam05506
700598007269	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
700598007270	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598007271	potential frameshift: common BLAST hit: gi|327402439|ref|YP_004343277.1| RHS repeat-associated core domain-containing protein
700598007272	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598007273	PA14 domain; Region: PA14; cl08459
700598007274	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598007275	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598007276	ligand binding site [chemical binding]; other site
700598007277	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
700598007278	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700598007279	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598007280	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598007281	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
700598007282	NADH(P)-binding; Region: NAD_binding_10; pfam13460
700598007283	NAD binding site [chemical binding]; other site
700598007284	substrate binding site [chemical binding]; other site
700598007285	putative active site [active]
700598007286	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598007287	SusD family; Region: SusD; pfam07980
700598007288	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007289	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007290	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598007291	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007292	Response regulator receiver domain; Region: Response_reg; pfam00072
700598007293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007294	active site
700598007295	phosphorylation site [posttranslational modification]
700598007296	intermolecular recognition site; other site
700598007297	dimerization interface [polypeptide binding]; other site
700598007298	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598007299	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007300	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598007301	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598007302	active site
700598007303	catalytic tetrad [active]
700598007304	Pirin-related protein [General function prediction only]; Region: COG1741
700598007305	Pirin; Region: Pirin; pfam02678
700598007306	Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576
700598007307	putative ligand binding site [chemical binding]; other site
700598007308	putative catalytic site [active]
700598007309	Protein of unknown function (DUF3823); Region: DUF3823; pfam12866
700598007310	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598007311	SusD family; Region: SusD; pfam07980
700598007312	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007313	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007314	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598007315	Galactose oxidase, central domain; Region: Kelch_3; cl02701
700598007316	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
700598007317	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
700598007318	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
700598007319	Chromate transporter; Region: Chromate_transp; pfam02417
700598007320	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
700598007321	substrate binding site [chemical binding]; other site
700598007322	active site
700598007323	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
700598007324	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700598007325	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598007326	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007327	cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662
700598007328	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
700598007329	NADP binding site [chemical binding]; other site
700598007330	putative substrate binding site [chemical binding]; other site
700598007331	active site
700598007332	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
700598007333	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
700598007334	tetrameric interface [polypeptide binding]; other site
700598007335	activator binding site; other site
700598007336	NADP binding site [chemical binding]; other site
700598007337	substrate binding site [chemical binding]; other site
700598007338	catalytic residues [active]
700598007339	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
700598007340	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598007341	short chain dehydrogenase; Provisional; Region: PRK06181
700598007342	NAD(P) binding site [chemical binding]; other site
700598007343	active site
700598007344	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
700598007345	putative active site [active]
700598007346	GIY-YIG motif/motif A; other site
700598007347	putative metal binding site [ion binding]; other site
700598007348	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598007349	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
700598007350	putative hydrophobic ligand binding site [chemical binding]; other site
700598007351	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
700598007352	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
700598007353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598007354	putative substrate translocation pore; other site
700598007355	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
700598007356	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
700598007357	conserved cys residue [active]
700598007358	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007359	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
700598007360	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
700598007361	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
700598007362	metal ion-dependent adhesion site (MIDAS); other site
700598007363	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
700598007364	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
700598007365	FAD binding domain; Region: FAD_binding_4; pfam01565
700598007366	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
700598007367	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
700598007368	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
700598007369	NAD binding site [chemical binding]; other site
700598007370	active site
700598007371	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
700598007372	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598007373	ATP binding site [chemical binding]; other site
700598007374	putative Mg++ binding site [ion binding]; other site
700598007375	helicase superfamily c-terminal domain; Region: HELICc; smart00490
700598007376	ATP-binding site [chemical binding]; other site
700598007377	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700598007378	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
700598007379	putative acyl-acceptor binding pocket; other site
700598007380	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
700598007381	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
700598007382	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
700598007383	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598007384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007385	active site
700598007386	phosphorylation site [posttranslational modification]
700598007387	intermolecular recognition site; other site
700598007388	dimerization interface [polypeptide binding]; other site
700598007389	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598007390	PAS fold; Region: PAS_3; pfam08447
700598007391	putative active site [active]
700598007392	heme pocket [chemical binding]; other site
700598007393	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598007394	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007395	ATP binding site [chemical binding]; other site
700598007396	Mg2+ binding site [ion binding]; other site
700598007397	G-X-G motif; other site
700598007398	Response regulator receiver domain; Region: Response_reg; pfam00072
700598007399	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007400	active site
700598007401	phosphorylation site [posttranslational modification]
700598007402	intermolecular recognition site; other site
700598007403	dimerization interface [polypeptide binding]; other site
700598007404	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
700598007405	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007406	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
700598007407	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007408	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
700598007409	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700598007410	Methyltransferase domain; Region: Methyltransf_12; pfam08242
700598007411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
700598007412	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
700598007413	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
700598007414	Cell division protein FtsL; Region: FtsL; cl11433
700598007415	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
700598007416	cyclase homology domain; Region: CHD; cd07302
700598007417	nucleotidyl binding site; other site
700598007418	metal binding site [ion binding]; metal-binding site
700598007419	dimer interface [polypeptide binding]; other site
700598007420	Predicted integral membrane protein [Function unknown]; Region: COG5616
700598007421	TPR repeat; Region: TPR_11; pfam13414
700598007422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598007423	TPR motif; other site
700598007424	binding surface
700598007425	TPR repeat; Region: TPR_11; pfam13414
700598007426	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598007427	binding surface
700598007428	TPR repeat; Region: TPR_11; pfam13414
700598007429	TPR motif; other site
700598007430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598007431	TPR motif; other site
700598007432	binding surface
700598007433	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
700598007434	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598007435	Walker A/P-loop; other site
700598007436	ATP binding site [chemical binding]; other site
700598007437	Q-loop/lid; other site
700598007438	ABC transporter signature motif; other site
700598007439	Walker B; other site
700598007440	D-loop; other site
700598007441	H-loop/switch region; other site
700598007442	TOBE domain; Region: TOBE_2; pfam08402
700598007443	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598007444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007445	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700598007446	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598007447	NAD(P) binding site [chemical binding]; other site
700598007448	active site
700598007449	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
700598007450	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
700598007451	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
700598007452	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598007453	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598007454	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
700598007455	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700598007456	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
700598007457	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700598007458	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
700598007459	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
700598007460	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700598007461	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
700598007462	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
700598007463	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
700598007464	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
700598007465	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
700598007466	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
700598007467	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
700598007468	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
700598007469	NADH dehydrogenase subunit G; Validated; Region: PRK08166
700598007470	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598007471	catalytic loop [active]
700598007472	iron binding site [ion binding]; other site
700598007473	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
700598007474	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
700598007475	[4Fe-4S] binding site [ion binding]; other site
700598007476	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
700598007477	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
700598007478	SLBB domain; Region: SLBB; pfam10531
700598007479	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
700598007480	NADH dehydrogenase subunit E; Validated; Region: PRK07539
700598007481	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
700598007482	putative dimer interface [polypeptide binding]; other site
700598007483	[2Fe-2S] cluster binding site [ion binding]; other site
700598007484	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
700598007485	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
700598007486	NADH dehydrogenase subunit D; Validated; Region: PRK06075
700598007487	NADH dehydrogenase subunit B; Validated; Region: PRK06411
700598007488	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
700598007489	FOG: CBS domain [General function prediction only]; Region: COG0517
700598007490	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
700598007491	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598007492	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598007493	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598007494	DNA binding residues [nucleotide binding]
700598007495	FecR protein; Region: FecR; pfam04773
700598007496	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007497	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007498	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598007499	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598007500	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598007501	SusD family; Region: SusD; pfam07980
700598007502	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
700598007503	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
700598007504	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598007505	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007506	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
700598007507	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598007508	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
700598007509	substrate binding site [chemical binding]; other site
700598007510	catalytic residues [active]
700598007511	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
700598007512	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598007513	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598007514	SusD family; Region: SusD; pfam07980
700598007515	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007516	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007517	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598007518	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007519	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598007520	Two component regulator propeller; Region: Reg_prop; pfam07494
700598007521	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598007522	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598007523	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598007524	dimer interface [polypeptide binding]; other site
700598007525	phosphorylation site [posttranslational modification]
700598007526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007527	ATP binding site [chemical binding]; other site
700598007528	Mg2+ binding site [ion binding]; other site
700598007529	G-X-G motif; other site
700598007530	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598007531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007532	active site
700598007533	phosphorylation site [posttranslational modification]
700598007534	intermolecular recognition site; other site
700598007535	dimerization interface [polypeptide binding]; other site
700598007536	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598007537	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007538	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700598007539	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
700598007540	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
700598007541	putative hydrophobic ligand binding site [chemical binding]; other site
700598007542	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
700598007543	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
700598007544	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
700598007545	active site
700598007546	catalytic site [active]
700598007547	substrate binding site [chemical binding]; other site
700598007548	Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322
700598007549	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
700598007550	GIY-YIG motif/motif A; other site
700598007551	active site
700598007552	catalytic site [active]
700598007553	putative DNA binding site [nucleotide binding]; other site
700598007554	metal binding site [ion binding]; metal-binding site
700598007555	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
700598007556	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598007557	active site
700598007558	HIGH motif; other site
700598007559	nucleotide binding site [chemical binding]; other site
700598007560	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
700598007561	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
700598007562	active site
700598007563	KMSKS motif; other site
700598007564	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
700598007565	tRNA binding surface [nucleotide binding]; other site
700598007566	anticodon binding site; other site
700598007567	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
700598007568	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
700598007569	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700598007570	active site
700598007571	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
700598007572	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700598007573	active site
700598007574	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
700598007575	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
700598007576	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
700598007577	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
700598007578	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007579	ATP binding site [chemical binding]; other site
700598007580	Mg2+ binding site [ion binding]; other site
700598007581	G-X-G motif; other site
700598007582	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
700598007583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
700598007584	ATP binding site [chemical binding]; other site
700598007585	Mg2+ binding site [ion binding]; other site
700598007586	G-X-G motif; other site
700598007587	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
700598007588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598007589	PAS domain; Region: PAS_9; pfam13426
700598007590	putative active site [active]
700598007591	heme pocket [chemical binding]; other site
700598007592	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598007593	dimer interface [polypeptide binding]; other site
700598007594	phosphorylation site [posttranslational modification]
700598007595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007596	ATP binding site [chemical binding]; other site
700598007597	Mg2+ binding site [ion binding]; other site
700598007598	G-X-G motif; other site
700598007599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007600	Response regulator receiver domain; Region: Response_reg; pfam00072
700598007601	active site
700598007602	phosphorylation site [posttranslational modification]
700598007603	intermolecular recognition site; other site
700598007604	dimerization interface [polypeptide binding]; other site
700598007605	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
700598007606	Protease prsW family; Region: PrsW-protease; pfam13367
700598007607	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700598007608	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598007609	Coenzyme A binding pocket [chemical binding]; other site
700598007610	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
700598007611	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
700598007612	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598007613	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598007614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007615	active site
700598007616	phosphorylation site [posttranslational modification]
700598007617	intermolecular recognition site; other site
700598007618	dimerization interface [polypeptide binding]; other site
700598007619	LytTr DNA-binding domain; Region: LytTR; smart00850
700598007620	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598007621	Histidine kinase; Region: His_kinase; pfam06580
700598007622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007623	ATP binding site [chemical binding]; other site
700598007624	Mg2+ binding site [ion binding]; other site
700598007625	G-X-G motif; other site
700598007626	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598007627	Two component regulator propeller; Region: Reg_prop; pfam07494
700598007628	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598007629	Histidine kinase; Region: His_kinase; pfam06580
700598007630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007631	Mg2+ binding site [ion binding]; other site
700598007632	G-X-G motif; other site
700598007633	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598007634	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
700598007635	active site
700598007636	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700598007637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598007638	S-adenosylmethionine binding site [chemical binding]; other site
700598007639	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700598007640	Methyltransferase domain; Region: Methyltransf_12; pfam08242
700598007641	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
700598007642	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
700598007643	active site
700598007644	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
700598007645	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
700598007646	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598007647	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
700598007648	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
700598007649	adenylosuccinate lyase; Provisional; Region: PRK09285
700598007650	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
700598007651	tetramer interface [polypeptide binding]; other site
700598007652	active site
700598007653	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700598007654	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
700598007655	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700598007656	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700598007657	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
700598007658	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
700598007659	G1 box; other site
700598007660	putative GEF interaction site [polypeptide binding]; other site
700598007661	GTP/Mg2+ binding site [chemical binding]; other site
700598007662	Switch I region; other site
700598007663	G2 box; other site
700598007664	G3 box; other site
700598007665	Switch II region; other site
700598007666	G4 box; other site
700598007667	G5 box; other site
700598007668	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
700598007669	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598007670	active site
700598007671	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598007672	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598007673	MgtC family; Region: MgtC; pfam02308
700598007674	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
700598007675	active site
700598007676	catalytic residues [active]
700598007677	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598007678	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598007679	FtsX-like permease family; Region: FtsX; pfam02687
700598007680	UGMP family protein; Validated; Region: PRK09604
700598007681	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
700598007682	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
700598007683	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598007684	S-adenosylmethionine binding site [chemical binding]; other site
700598007685	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598007686	binding surface
700598007687	TPR motif; other site
700598007688	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598007689	binding surface
700598007690	TPR motif; other site
700598007691	CHAT domain; Region: CHAT; pfam12770
700598007692	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598007693	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598007694	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598007695	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007696	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598007697	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007698	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007699	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598007700	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
700598007701	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598007702	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007703	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
700598007704	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598007705	hypothetical protein; Provisional; Region: PRK11281
700598007706	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
700598007707	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
700598007708	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598007709	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
700598007710	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598007711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007712	active site
700598007713	phosphorylation site [posttranslational modification]
700598007714	intermolecular recognition site; other site
700598007715	dimerization interface [polypeptide binding]; other site
700598007716	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598007717	DNA binding residues [nucleotide binding]
700598007718	dimerization interface [polypeptide binding]; other site
700598007719	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598007720	Histidine kinase; Region: HisKA_3; pfam07730
700598007721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007722	ATP binding site [chemical binding]; other site
700598007723	Mg2+ binding site [ion binding]; other site
700598007724	G-X-G motif; other site
700598007725	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598007726	dimer interface [polypeptide binding]; other site
700598007727	phosphorylation site [posttranslational modification]
700598007728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007729	ATP binding site [chemical binding]; other site
700598007730	Mg2+ binding site [ion binding]; other site
700598007731	G-X-G motif; other site
700598007732	Response regulator receiver domain; Region: Response_reg; pfam00072
700598007733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007734	active site
700598007735	phosphorylation site [posttranslational modification]
700598007736	intermolecular recognition site; other site
700598007737	dimerization interface [polypeptide binding]; other site
700598007738	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
700598007739	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598007740	catalytic loop [active]
700598007741	iron binding site [ion binding]; other site
700598007742	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
700598007743	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598007744	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
700598007745	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
700598007746	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598007747	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598007748	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598007749	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598007750	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007751	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
700598007752	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598007753	FecR protein; Region: FecR; pfam04773
700598007754	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598007755	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598007756	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598007757	DNA binding residues [nucleotide binding]
700598007758	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598007759	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598007760	catalytic residues [active]
700598007761	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598007762	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598007763	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007764	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007765	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598007766	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007767	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598007768	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598007769	catalytic residues [active]
700598007770	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598007771	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598007772	catalytic residues [active]
700598007773	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
700598007774	active site
700598007775	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
700598007776	active site
700598007777	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598007778	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598007779	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007780	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007781	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598007782	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007783	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598007784	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598007785	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007786	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598007787	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007788	Histidine kinase; Region: His_kinase; pfam06580
700598007789	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
700598007790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007791	active site
700598007792	phosphorylation site [posttranslational modification]
700598007793	intermolecular recognition site; other site
700598007794	dimerization interface [polypeptide binding]; other site
700598007795	LytTr DNA-binding domain; Region: LytTR; smart00850
700598007796	Histidine kinase; Region: His_kinase; pfam06580
700598007797	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598007798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007799	active site
700598007800	phosphorylation site [posttranslational modification]
700598007801	intermolecular recognition site; other site
700598007802	dimerization interface [polypeptide binding]; other site
700598007803	LytTr DNA-binding domain; Region: LytTR; smart00850
700598007804	Uncharacterized conserved protein [Function unknown]; Region: COG3391
700598007805	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
700598007806	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007807	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598007808	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598007809	active site
700598007810	metal binding site [ion binding]; metal-binding site
700598007811	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
700598007812	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
700598007813	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
700598007814	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
700598007815	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
700598007816	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
700598007817	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
700598007818	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598007819	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598007820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598007821	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598007822	putative substrate translocation pore; other site
700598007823	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
700598007824	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598007825	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598007826	ligand binding site [chemical binding]; other site
700598007827	flexible hinge region; other site
700598007828	Domain of unknown function DUF302; Region: DUF302; cl01364
700598007829	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
700598007830	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
700598007831	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
700598007832	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
700598007833	Cellulose binding domain; Region: CBM_3; smart01067
700598007834	Cellulose binding domain; Region: CBM_3; pfam00942
700598007835	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598007836	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
700598007837	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
700598007838	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
700598007839	Interdomain contacts; other site
700598007840	Cytokine receptor motif; other site
700598007841	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598007842	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598007843	SusD family; Region: SusD; pfam07980
700598007844	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007845	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007846	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598007847	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598007848	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598007849	Two component regulator propeller; Region: Reg_prop; pfam07494
700598007850	Two component regulator propeller; Region: Reg_prop; pfam07494
700598007851	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598007852	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598007853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598007854	dimer interface [polypeptide binding]; other site
700598007855	phosphorylation site [posttranslational modification]
700598007856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007857	ATP binding site [chemical binding]; other site
700598007858	Mg2+ binding site [ion binding]; other site
700598007859	G-X-G motif; other site
700598007860	Response regulator receiver domain; Region: Response_reg; pfam00072
700598007861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007862	active site
700598007863	phosphorylation site [posttranslational modification]
700598007864	intermolecular recognition site; other site
700598007865	dimerization interface [polypeptide binding]; other site
700598007866	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598007867	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007868	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
700598007869	Major royal jelly protein; Region: MRJP; pfam03022
700598007870	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
700598007871	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
700598007872	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
700598007873	active site
700598007874	catalytic site [active]
700598007875	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
700598007876	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
700598007877	active site
700598007878	catalytic site [active]
700598007879	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
700598007880	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
700598007881	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
700598007882	catalytic site [active]
700598007883	active site
700598007884	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
700598007885	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
700598007886	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
700598007887	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
700598007888	[2Fe-2S] cluster binding site [ion binding]; other site
700598007889	Predicted membrane protein [Function unknown]; Region: COG2323
700598007890	Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719
700598007891	dimer interface [polypeptide binding]; other site
700598007892	substrate binding site [chemical binding]; other site
700598007893	metal binding sites [ion binding]; metal-binding site
700598007894	Competence-damaged protein; Region: CinA; pfam02464
700598007895	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
700598007896	dimerization interface [polypeptide binding]; other site
700598007897	metal binding site [ion binding]; metal-binding site
700598007898	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
700598007899	Mechanosensitive ion channel; Region: MS_channel; pfam00924
700598007900	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598007901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007902	active site
700598007903	phosphorylation site [posttranslational modification]
700598007904	intermolecular recognition site; other site
700598007905	dimerization interface [polypeptide binding]; other site
700598007906	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
700598007907	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598007908	putative active site [active]
700598007909	heme pocket [chemical binding]; other site
700598007910	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598007911	putative active site [active]
700598007912	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598007913	heme pocket [chemical binding]; other site
700598007914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598007915	dimer interface [polypeptide binding]; other site
700598007916	phosphorylation site [posttranslational modification]
700598007917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007918	ATP binding site [chemical binding]; other site
700598007919	Mg2+ binding site [ion binding]; other site
700598007920	G-X-G motif; other site
700598007921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
700598007922	active site
700598007923	phosphorylation site [posttranslational modification]
700598007924	intermolecular recognition site; other site
700598007925	dimerization interface [polypeptide binding]; other site
700598007926	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
700598007927	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
700598007928	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700598007929	Domain of unknown function (DUF1793); Region: DUF1793; pfam08760
700598007930	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007931	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598007932	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598007933	DNA binding site [nucleotide binding]
700598007934	domain linker motif; other site
700598007935	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598007936	dimerization interface [polypeptide binding]; other site
700598007937	ligand binding site [chemical binding]; other site
700598007938	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
700598007939	beta-alpha-beta structure motif; other site
700598007940	NAD binding pocket [chemical binding]; other site
700598007941	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598007942	SusD family; Region: SusD; pfam07980
700598007943	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598007944	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598007945	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598007946	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598007947	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598007948	FtsX-like permease family; Region: FtsX; pfam02687
700598007949	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598007950	FtsX-like permease family; Region: FtsX; pfam02687
700598007951	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
700598007952	putative hydrophobic ligand binding site [chemical binding]; other site
700598007953	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598007954	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598007955	Ligand Binding Site [chemical binding]; other site
700598007956	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
700598007957	metal-binding site [ion binding]
700598007958	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598007959	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
700598007960	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598007961	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007962	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
700598007963	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700598007964	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598007965	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598007966	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598007967	Response regulator receiver domain; Region: Response_reg; pfam00072
700598007968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598007969	active site
700598007970	phosphorylation site [posttranslational modification]
700598007971	intermolecular recognition site; other site
700598007972	dimerization interface [polypeptide binding]; other site
700598007973	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598007974	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700598007975	Walker A motif; other site
700598007976	ATP binding site [chemical binding]; other site
700598007977	Walker B motif; other site
700598007978	arginine finger; other site
700598007979	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598007980	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
700598007981	Histidine kinase; Region: HisKA_2; pfam07568
700598007982	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598007983	ATP binding site [chemical binding]; other site
700598007984	Mg2+ binding site [ion binding]; other site
700598007985	G-X-G motif; other site
700598007986	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598007987	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598007988	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
700598007989	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
700598007990	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
700598007991	active site
700598007992	Predicted membrane protein [Function unknown]; Region: COG2259
700598007993	Protein of unknown function, DUF606; Region: DUF606; pfam04657
700598007994	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
700598007995	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598007996	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
700598007997	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598007998	FtsX-like permease family; Region: FtsX; pfam02687
700598007999	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598008000	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598008001	FtsX-like permease family; Region: FtsX; pfam02687
700598008002	YCII-related domain; Region: YCII; cl00999
700598008003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598008004	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598008005	putative substrate translocation pore; other site
700598008006	Pectic acid lyase; Region: Pec_lyase; pfam09492
700598008007	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
700598008008	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13300
700598008009	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
700598008010	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
700598008011	DNA-binding site [nucleotide binding]; DNA binding site
700598008012	RNA-binding motif; other site
700598008013	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
700598008014	RNA recognition motif; Region: RRM; smart00360
700598008015	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
700598008016	circadian clock protein KaiC; Reviewed; Region: PRK09302
700598008017	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
700598008018	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
700598008019	Walker A motif; other site
700598008020	Walker A motif; other site
700598008021	ATP binding site [chemical binding]; other site
700598008022	Walker B motif; other site
700598008023	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
700598008024	Walker A motif; other site
700598008025	ATP binding site [chemical binding]; other site
700598008026	Walker B motif; other site
700598008027	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
700598008028	tetramer interface [polypeptide binding]; other site
700598008029	dimer interface [polypeptide binding]; other site
700598008030	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
700598008031	tetramer interface [polypeptide binding]; other site
700598008032	dimer interface [polypeptide binding]; other site
700598008033	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
700598008034	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598008035	putative active site [active]
700598008036	heme pocket [chemical binding]; other site
700598008037	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598008038	dimer interface [polypeptide binding]; other site
700598008039	phosphorylation site [posttranslational modification]
700598008040	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598008041	ATP binding site [chemical binding]; other site
700598008042	Mg2+ binding site [ion binding]; other site
700598008043	G-X-G motif; other site
700598008044	Response regulator receiver domain; Region: Response_reg; pfam00072
700598008045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598008046	active site
700598008047	phosphorylation site [posttranslational modification]
700598008048	intermolecular recognition site; other site
700598008049	Right handed beta helix region; Region: Beta_helix; pfam13229
700598008050	flagellin; Validated; Region: PRK08026
700598008051	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598008052	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
700598008053	Uncharacterized conserved protein [Function unknown]; Region: COG4544
700598008054	DNA Polymerase Y-family; Region: PolY_like; cd03468
700598008055	active site
700598008056	DNA binding site [nucleotide binding]
700598008057	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
700598008058	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
700598008059	putative active site [active]
700598008060	putative PHP Thumb interface [polypeptide binding]; other site
700598008061	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
700598008062	generic binding surface II; other site
700598008063	generic binding surface I; other site
700598008064	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
700598008065	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
700598008066	active site
700598008067	Na/Ca binding site [ion binding]; other site
700598008068	catalytic site [active]
700598008069	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
700598008070	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
700598008071	dimerization interface [polypeptide binding]; other site
700598008072	metal binding site [ion binding]; metal-binding site
700598008073	PAS fold; Region: PAS_4; pfam08448
700598008074	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598008075	putative active site [active]
700598008076	heme pocket [chemical binding]; other site
700598008077	GAF domain; Region: GAF_2; pfam13185
700598008078	GAF domain; Region: GAF; pfam01590
700598008079	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
700598008080	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598008081	putative active site [active]
700598008082	heme pocket [chemical binding]; other site
700598008083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598008084	dimer interface [polypeptide binding]; other site
700598008085	phosphorylation site [posttranslational modification]
700598008086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598008087	ATP binding site [chemical binding]; other site
700598008088	Mg2+ binding site [ion binding]; other site
700598008089	G-X-G motif; other site
700598008090	cyanophycin synthetase; Provisional; Region: PRK14016
700598008091	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700598008092	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700598008093	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700598008094	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700598008095	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
700598008096	catalytic nucleophile [active]
700598008097	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
700598008098	proposed catalytic triad [active]
700598008099	active site nucleophile [active]
700598008100	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008101	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008102	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598008103	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598008104	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598008105	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598008106	C-terminal peptidase (prc); Region: prc; TIGR00225
700598008107	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
700598008108	protein binding site [polypeptide binding]; other site
700598008109	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
700598008110	Catalytic dyad [active]
700598008111	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598008112	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598008113	S-adenosylmethionine binding site [chemical binding]; other site
700598008114	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
700598008115	active site
700598008116	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
700598008117	IPT/TIG domain; Region: TIG; pfam01833
700598008118	IPT/TIG domain; Region: TIG; pfam01833
700598008119	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
700598008120	NHL repeat; Region: NHL; pfam01436
700598008121	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
700598008122	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
700598008123	dimer interface [polypeptide binding]; other site
700598008124	ADP-ribose binding site [chemical binding]; other site
700598008125	active site
700598008126	nudix motif; other site
700598008127	metal binding site [ion binding]; metal-binding site
700598008128	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
700598008129	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598008130	FtsX-like permease family; Region: FtsX; pfam02687
700598008131	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598008132	FtsX-like permease family; Region: FtsX; pfam02687
700598008133	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598008134	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
700598008135	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598008136	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598008137	dimerization interface [polypeptide binding]; other site
700598008138	putative DNA binding site [nucleotide binding]; other site
700598008139	putative Zn2+ binding site [ion binding]; other site
700598008140	NmrA-like family; Region: NmrA; pfam05368
700598008141	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
700598008142	NADP binding site [chemical binding]; other site
700598008143	active site
700598008144	regulatory binding site [polypeptide binding]; other site
700598008145	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598008146	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598008147	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598008148	DNA binding residues [nucleotide binding]
700598008149	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
700598008150	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
700598008151	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
700598008152	active site
700598008153	catalytic residues [active]
700598008154	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
700598008155	active site
700598008156	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
700598008157	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598008158	SusD family; Region: SusD; pfam07980
700598008159	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008160	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008161	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598008162	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
700598008163	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
700598008164	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
700598008165	Interdomain contacts; other site
700598008166	Cytokine receptor motif; other site
700598008167	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
700598008168	Cellulose binding domain; Region: CBM_3; smart01067
700598008169	Cellulose binding domain; Region: CBM_3; smart01067
700598008170	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598008171	Two component regulator propeller; Region: Reg_prop; pfam07494
700598008172	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598008173	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598008174	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598008175	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598008176	dimer interface [polypeptide binding]; other site
700598008177	phosphorylation site [posttranslational modification]
700598008178	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598008179	ATP binding site [chemical binding]; other site
700598008180	Mg2+ binding site [ion binding]; other site
700598008181	G-X-G motif; other site
700598008182	Response regulator receiver domain; Region: Response_reg; pfam00072
700598008183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598008184	active site
700598008185	phosphorylation site [posttranslational modification]
700598008186	intermolecular recognition site; other site
700598008187	dimerization interface [polypeptide binding]; other site
700598008188	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598008189	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
700598008190	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
700598008191	SPFH domain / Band 7 family; Region: Band_7; pfam01145
700598008192	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
700598008193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598008194	putative substrate translocation pore; other site
700598008195	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
700598008196	EthD domain; Region: EthD; cl17553
700598008197	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598008198	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700598008199	Coenzyme A binding pocket [chemical binding]; other site
700598008200	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
700598008201	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
700598008202	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
700598008203	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598008204	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598008205	ligand binding site [chemical binding]; other site
700598008206	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
700598008207	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598008208	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598008209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598008210	active site
700598008211	phosphorylation site [posttranslational modification]
700598008212	intermolecular recognition site; other site
700598008213	dimerization interface [polypeptide binding]; other site
700598008214	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598008215	DNA binding residues [nucleotide binding]
700598008216	dimerization interface [polypeptide binding]; other site
700598008217	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598008218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598008219	ATP binding site [chemical binding]; other site
700598008220	Mg2+ binding site [ion binding]; other site
700598008221	G-X-G motif; other site
700598008222	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663
700598008223	IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603
700598008224	NHL repeat; Region: NHL; pfam01436
700598008225	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598008226	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598008227	SusD family; Region: SusD; pfam07980
700598008228	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008229	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008230	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598008231	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598008232	FecR protein; Region: FecR; pfam04773
700598008233	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598008234	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598008235	DNA binding residues [nucleotide binding]
700598008236	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598008237	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598008238	ligand binding site [chemical binding]; other site
700598008239	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
700598008240	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
700598008241	active site
700598008242	DoxX-like family; Region: DoxX_2; pfam13564
700598008243	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598008244	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700598008245	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
700598008246	Coenzyme A binding pocket [chemical binding]; other site
700598008247	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
700598008248	conserved cys residue [active]
700598008249	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
700598008250	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
700598008251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
700598008252	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
700598008253	ApbE family; Region: ApbE; pfam02424
700598008254	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
700598008255	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
700598008256	30S subunit binding site; other site
700598008257	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
700598008258	Domain of unknown function DUF20; Region: UPF0118; pfam01594
700598008259	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
700598008260	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598008261	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598008262	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598008263	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
700598008264	putative NAD(P) binding site [chemical binding]; other site
700598008265	homodimer interface [polypeptide binding]; other site
700598008266	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
700598008267	BON domain; Region: BON; pfam04972
700598008268	BON domain; Region: BON; pfam04972
700598008269	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
700598008270	Predicted membrane protein [Function unknown]; Region: COG2311
700598008271	Protein of unknown function (DUF418); Region: DUF418; cl12135
700598008272	Protein of unknown function (DUF418); Region: DUF418; pfam04235
700598008273	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
700598008274	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
700598008275	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
700598008276	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
700598008277	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
700598008278	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598008279	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598008280	binding surface
700598008281	TPR motif; other site
700598008282	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598008283	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598008284	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598008285	binding surface
700598008286	TPR motif; other site
700598008287	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598008288	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598008289	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
700598008290	dimer interface [polypeptide binding]; other site
700598008291	phosphorylation site [posttranslational modification]
700598008292	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598008293	ATP binding site [chemical binding]; other site
700598008294	Mg2+ binding site [ion binding]; other site
700598008295	G-X-G motif; other site
700598008296	Domain of unknown function (DUF3859); Region: DUF3859; pfam12975
700598008297	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598008298	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598008299	SUKH-4 immunity protein; Region: SUKH-4; pfam14435
700598008300	PhnA protein; Region: PhnA; pfam03831
700598008301	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
700598008302	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598008303	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008304	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598008305	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598008306	FecR protein; Region: FecR; pfam04773
700598008307	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598008308	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598008309	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598008310	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598008311	DNA binding residues [nucleotide binding]
700598008312	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
700598008313	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
700598008314	YceI-like domain; Region: YceI; pfam04264
700598008315	cytochrome c-550; Provisional; Region: psbV; cl17239
700598008316	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
700598008317	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700598008318	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598008319	non-specific DNA binding site [nucleotide binding]; other site
700598008320	salt bridge; other site
700598008321	sequence-specific DNA binding site [nucleotide binding]; other site
700598008322	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598008323	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
700598008324	FAD binding domain; Region: FAD_binding_4; pfam01565
700598008325	Berberine and berberine like; Region: BBE; pfam08031
700598008326	Protein of unknown function (DUF3738); Region: DUF3738; cl11887
700598008327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598008328	active site
700598008329	phosphorylation site [posttranslational modification]
700598008330	intermolecular recognition site; other site
700598008331	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598008332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598008333	active site
700598008334	phosphorylation site [posttranslational modification]
700598008335	intermolecular recognition site; other site
700598008336	dimerization interface [polypeptide binding]; other site
700598008337	DinB superfamily; Region: DinB_2; pfam12867
700598008338	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598008339	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598008340	Outer membrane efflux protein; Region: OEP; pfam02321
700598008341	Outer membrane efflux protein; Region: OEP; pfam02321
700598008342	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598008343	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598008344	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598008345	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598008346	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
700598008347	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598008348	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
700598008349	active site
700598008350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
700598008351	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
700598008352	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598008353	DNA-binding site [nucleotide binding]; DNA binding site
700598008354	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598008355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598008356	homodimer interface [polypeptide binding]; other site
700598008357	catalytic residue [active]
700598008358	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700598008359	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700598008360	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598008361	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
700598008362	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
700598008363	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
700598008364	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
700598008365	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
700598008366	substrate binding site [chemical binding]; other site
700598008367	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598008368	binding surface
700598008369	TPR motif; other site
700598008370	TPR repeat; Region: TPR_11; pfam13414
700598008371	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
700598008372	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598008373	putative metal binding site [ion binding]; other site
700598008374	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598008375	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
700598008376	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598008377	FtsX-like permease family; Region: FtsX; pfam02687
700598008378	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598008379	FtsX-like permease family; Region: FtsX; pfam02687
700598008380	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
700598008381	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
700598008382	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598008383	active site
700598008384	metal binding site [ion binding]; metal-binding site
700598008385	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598008386	SusD family; Region: SusD; pfam07980
700598008387	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598008388	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008389	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008390	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598008391	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598008392	FecR protein; Region: FecR; pfam04773
700598008393	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598008394	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598008395	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598008396	DNA binding residues [nucleotide binding]
700598008397	DoxX-like family; Region: DoxX_2; pfam13564
700598008398	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598008399	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598008400	dimerization interface [polypeptide binding]; other site
700598008401	putative DNA binding site [nucleotide binding]; other site
700598008402	putative Zn2+ binding site [ion binding]; other site
700598008403	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
700598008404	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598008405	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598008406	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
700598008407	SnoaL-like domain; Region: SnoaL_2; pfam12680
700598008408	cyanate hydratase; Validated; Region: PRK02866
700598008409	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cl07841
700598008410	oligomer interface [polypeptide binding]; other site
700598008411	active site
700598008412	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
700598008413	active site clefts [active]
700598008414	zinc binding site [ion binding]; other site
700598008415	dimer interface [polypeptide binding]; other site
700598008416	TIR domain; Region: TIR_2; pfam13676
700598008417	TIR domain; Region: TIR_2; pfam13676
700598008418	patatin-related protein; Region: TIGR03607
700598008419	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
700598008420	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
700598008421	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
700598008422	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
700598008423	Transposase; Region: DDE_Tnp_ISL3; pfam01610
700598008424	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
700598008425	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700598008426	active site
700598008427	DNA binding site [nucleotide binding]
700598008428	Int/Topo IB signature motif; other site
700598008429	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
700598008430	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
700598008431	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598008432	non-specific DNA binding site [nucleotide binding]; other site
700598008433	salt bridge; other site
700598008434	sequence-specific DNA binding site [nucleotide binding]; other site
700598008435	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
700598008436	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
700598008437	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
700598008438	AAA-like domain; Region: AAA_10; pfam12846
700598008439	Walker A motif; other site
700598008440	ATP binding site [chemical binding]; other site
700598008441	Walker B motif; other site
700598008442	Domain of unknown function (DUF4224); Region: DUF4224; pfam13986
700598008443	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700598008444	active site
700598008445	DNA binding site [nucleotide binding]
700598008446	Int/Topo IB signature motif; other site
700598008447	TrwC relaxase; Region: TrwC; pfam08751
700598008448	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
700598008449	AAA domain; Region: AAA_22; pfam13401
700598008450	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598008451	Walker A motif; other site
700598008452	ATP binding site [chemical binding]; other site
700598008453	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
700598008454	Walker B motif; other site
700598008455	arginine finger; other site
700598008456	Family description; Region: UvrD_C_2; pfam13538
700598008457	CHC2 zinc finger; Region: zf-CHC2; cl17510
700598008458	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
700598008459	DNA binding residues [nucleotide binding]
700598008460	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446
700598008461	putative RNA polymerase sigma E protein; Provisional; Region: PRK13919
700598008462	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
700598008463	DNA binding residues [nucleotide binding]
700598008464	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598008465	salt bridge; other site
700598008466	non-specific DNA binding site [nucleotide binding]; other site
700598008467	sequence-specific DNA binding site [nucleotide binding]; other site
700598008468	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
700598008469	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
700598008470	catalytic residues [active]
700598008471	catalytic nucleophile [active]
700598008472	Helix-turn-helix domain; Region: HTH_17; pfam12728
700598008473	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598008474	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
700598008475	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598008476	DNA binding residues [nucleotide binding]
700598008477	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700598008478	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
700598008479	TM2 domain; Region: TM2; pfam05154
700598008480	Putative methyltransferase; Region: Methyltransf_16; pfam10294
700598008481	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598008482	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598008483	catalytic residues [active]
700598008484	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598008485	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598008486	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008487	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008488	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598008489	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598008490	FecR protein; Region: FecR; pfam04773
700598008491	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598008492	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598008493	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598008494	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
700598008495	Secretin and TonB N terminus short domain; Region: STN; smart00965
700598008496	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008497	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598008498	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598008499	FecR protein; Region: FecR; pfam04773
700598008500	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598008501	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008502	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598008503	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
700598008504	N-terminal plug; other site
700598008505	ligand-binding site [chemical binding]; other site
700598008506	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
700598008507	DoxX-like family; Region: DoxX_2; pfam13564
700598008508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
700598008509	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
700598008510	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
700598008511	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598008512	hydrophobic ligand binding site; other site
700598008513	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598008514	dimerization interface [polypeptide binding]; other site
700598008515	putative DNA binding site [nucleotide binding]; other site
700598008516	putative Zn2+ binding site [ion binding]; other site
700598008517	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598008518	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598008519	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598008520	DNA binding residues [nucleotide binding]
700598008521	Ubiquitin-like proteins; Region: UBQ; cl00155
700598008522	charged pocket; other site
700598008523	hydrophobic patch; other site
700598008524	VPS10 domain; Region: VPS10; smart00602
700598008525	VPS10 domain; Region: VPS10; smart00602
700598008526	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700598008527	FecR protein; Region: FecR; pfam04773
700598008528	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598008529	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008530	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008531	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598008532	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598008533	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598008534	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598008535	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598008536	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598008537	DNA binding residues [nucleotide binding]
700598008538	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
700598008539	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700598008540	Zn2+ binding site [ion binding]; other site
700598008541	Mg2+ binding site [ion binding]; other site
700598008542	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
700598008543	active site
700598008544	catalytic residues [active]
700598008545	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598008546	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598008547	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008548	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008549	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598008550	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
700598008551	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598008552	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598008553	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598008554	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598008555	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598008556	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
700598008557	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
700598008558	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
700598008559	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
700598008560	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
700598008561	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598008562	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598008563	active site
700598008564	catalytic tetrad [active]
700598008565	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598008566	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598008567	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598008568	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598008569	active site
700598008570	phosphorylation site [posttranslational modification]
700598008571	intermolecular recognition site; other site
700598008572	dimerization interface [polypeptide binding]; other site
700598008573	LytTr DNA-binding domain; Region: LytTR; smart00850
700598008574	Fibronectin type 3 domain; Region: FN3; smart00060
700598008575	Interdomain contacts; other site
700598008576	Cytokine receptor motif; other site
700598008577	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598008578	dimerization interface [polypeptide binding]; other site
700598008579	putative DNA binding site [nucleotide binding]; other site
700598008580	putative Zn2+ binding site [ion binding]; other site
700598008581	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
700598008582	putative hydrophobic ligand binding site [chemical binding]; other site
700598008583	RibD C-terminal domain; Region: RibD_C; cl17279
700598008584	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
700598008585	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
700598008586	putative NAD(P) binding site [chemical binding]; other site
700598008587	homodimer interface [polypeptide binding]; other site
700598008588	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598008589	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598008590	putative Zn2+ binding site [ion binding]; other site
700598008591	putative DNA binding site [nucleotide binding]; other site
700598008592	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
700598008593	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
700598008594	Sulfate transporter family; Region: Sulfate_transp; pfam00916
700598008595	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598008596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598008597	S-adenosylmethionine binding site [chemical binding]; other site
700598008598	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598008599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598008600	S-adenosylmethionine binding site [chemical binding]; other site
700598008601	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598008602	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598008603	ligand binding site [chemical binding]; other site
700598008604	flexible hinge region; other site
700598008605	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700598008606	putative switch regulator; other site
700598008607	non-specific DNA interactions [nucleotide binding]; other site
700598008608	DNA binding site [nucleotide binding]
700598008609	sequence specific DNA binding site [nucleotide binding]; other site
700598008610	putative cAMP binding site [chemical binding]; other site
700598008611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598008612	S-adenosylmethionine binding site [chemical binding]; other site
700598008613	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
700598008614	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598008615	Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971
700598008616	Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089
700598008617	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972
700598008618	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
700598008619	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598008620	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
700598008621	active site
700598008622	catalytic triad [active]
700598008623	oxyanion hole [active]
700598008624	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
700598008625	active site
700598008626	catalytic triad [active]
700598008627	oxyanion hole [active]
700598008628	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
700598008629	active site
700598008630	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598008631	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
700598008632	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
700598008633	NHL repeat; Region: NHL; pfam01436
700598008634	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598008635	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598008636	SusD family; Region: SusD; pfam07980
700598008637	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598008638	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008639	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008640	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598008641	FecR protein; Region: FecR; pfam04773
700598008642	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598008643	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598008644	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598008645	DNA binding residues [nucleotide binding]
700598008646	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
700598008647	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
700598008648	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
700598008649	Response regulator receiver domain; Region: Response_reg; pfam00072
700598008650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598008651	active site
700598008652	phosphorylation site [posttranslational modification]
700598008653	intermolecular recognition site; other site
700598008654	dimerization interface [polypeptide binding]; other site
700598008655	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598008656	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598008657	ligand binding site [chemical binding]; other site
700598008658	flexible hinge region; other site
700598008659	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
700598008660	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
700598008661	FAD binding domain; Region: FAD_binding_4; pfam01565
700598008662	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
700598008663	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
700598008664	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598008665	TPR motif; other site
700598008666	binding surface
700598008667	Family description; Region: VCBS; pfam13517
700598008668	Family description; Region: VCBS; pfam13517
700598008669	Family description; Region: VCBS; pfam13517
700598008670	Family description; Region: VCBS; pfam13517
700598008671	Family description; Region: VCBS; pfam13517
700598008672	Family description; Region: VCBS; pfam13517
700598008673	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
700598008674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598008675	active site
700598008676	phosphorylation site [posttranslational modification]
700598008677	intermolecular recognition site; other site
700598008678	dimerization interface [polypeptide binding]; other site
700598008679	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
700598008680	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
700598008681	putative active site [active]
700598008682	catalytic site [active]
700598008683	putative metal binding site [ion binding]; other site
700598008684	oligomer interface [polypeptide binding]; other site
700598008685	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700598008686	catalytic core [active]
700598008687	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
700598008688	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700598008689	nucleotide binding site [chemical binding]; other site
700598008690	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
700598008691	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700598008692	nucleotide binding site [chemical binding]; other site
700598008693	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
700598008694	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
700598008695	putative ligand binding site [chemical binding]; other site
700598008696	putative NAD binding site [chemical binding]; other site
700598008697	catalytic site [active]
700598008698	polyol permease family; Region: 2A0118; TIGR00897
700598008699	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598008700	putative substrate translocation pore; other site
700598008701	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700598008702	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
700598008703	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700598008704	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598008705	hydrophobic ligand binding site; other site
700598008706	DNA helicase, putative; Region: TIGR00376
700598008707	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598008708	ATP binding site [chemical binding]; other site
700598008709	putative Mg++ binding site [ion binding]; other site
700598008710	AAA domain; Region: AAA_12; pfam13087
700598008711	short chain dehydrogenase; Provisional; Region: PRK06500
700598008712	classical (c) SDRs; Region: SDR_c; cd05233
700598008713	NAD(P) binding site [chemical binding]; other site
700598008714	active site
700598008715	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598008716	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598008717	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
700598008718	Domain of unknown function DUF20; Region: UPF0118; pfam01594
700598008719	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
700598008720	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598008721	PAS domain; Region: PAS_9; pfam13426
700598008722	putative active site [active]
700598008723	heme pocket [chemical binding]; other site
700598008724	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598008725	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598008726	putative active site [active]
700598008727	heme pocket [chemical binding]; other site
700598008728	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598008729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598008730	putative active site [active]
700598008731	heme pocket [chemical binding]; other site
700598008732	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598008733	putative active site [active]
700598008734	heme pocket [chemical binding]; other site
700598008735	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598008736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598008737	ATP binding site [chemical binding]; other site
700598008738	Mg2+ binding site [ion binding]; other site
700598008739	G-X-G motif; other site
700598008740	Methane oxygenase PmoA; Region: PmoA; pfam14100
700598008741	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598008742	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598008743	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598008744	Cupin domain; Region: Cupin_2; pfam07883
700598008745	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
700598008746	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598008747	sugar binding site [chemical binding]; other site
700598008748	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598008749	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598008750	sugar binding site [chemical binding]; other site
700598008751	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598008752	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
700598008753	active site
700598008754	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598008755	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
700598008756	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598008757	active site
700598008758	motif I; other site
700598008759	motif II; other site
700598008760	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598008761	FAD binding domain; Region: FAD_binding_4; pfam01565
700598008762	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700598008763	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598008764	S-adenosylmethionine binding site [chemical binding]; other site
700598008765	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
700598008766	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577
700598008767	putative active site [active]
700598008768	catalytic site [active]
700598008769	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
700598008770	Alkaline phosphatase homologues; Region: alkPPc; smart00098
700598008771	active site
700598008772	dimer interface [polypeptide binding]; other site
700598008773	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598008774	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598008775	SusD family; Region: SusD; pfam07980
700598008776	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008777	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008778	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598008779	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598008780	FecR protein; Region: FecR; pfam04773
700598008781	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598008782	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598008783	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598008784	DNA binding residues [nucleotide binding]
700598008785	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598008786	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598008787	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598008788	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008789	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008790	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598008791	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598008792	FecR protein; Region: FecR; pfam04773
700598008793	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598008794	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598008795	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598008796	DNA binding residues [nucleotide binding]
700598008797	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
700598008798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598008799	putative substrate translocation pore; other site
700598008800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598008801	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
700598008802	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598008803	ATP binding site [chemical binding]; other site
700598008804	putative Mg++ binding site [ion binding]; other site
700598008805	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598008806	nucleotide binding region [chemical binding]; other site
700598008807	ATP-binding site [chemical binding]; other site
700598008808	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598008809	TPR motif; other site
700598008810	TPR repeat; Region: TPR_11; pfam13414
700598008811	binding surface
700598008812	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598008813	binding surface
700598008814	TPR motif; other site
700598008815	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598008816	binding surface
700598008817	TPR motif; other site
700598008818	TPR repeat; Region: TPR_11; pfam13414
700598008819	TPR repeat; Region: TPR_11; pfam13414
700598008820	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
700598008821	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
700598008822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598008823	putative substrate translocation pore; other site
700598008824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598008825	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598008826	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598008827	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598008828	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598008829	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598008830	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598008831	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598008832	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
700598008833	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
700598008834	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598008835	hydrophobic ligand binding site; other site
700598008836	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
700598008837	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598008838	catalytic loop [active]
700598008839	iron binding site [ion binding]; other site
700598008840	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
700598008841	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
700598008842	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598008843	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
700598008844	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598008845	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598008846	Protoglobin; Region: Protoglobin; pfam11563
700598008847	Domain of unknown function (DUF1793); Region: DUF1793; pfam08760
700598008848	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
700598008849	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
700598008850	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700598008851	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
700598008852	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598008853	motif II; other site
700598008854	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
700598008855	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
700598008856	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
700598008857	Predicted membrane protein [Function unknown]; Region: COG5373
700598008858	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700598008859	active site
700598008860	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
700598008861	30S subunit binding site; other site
700598008862	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598008863	Ligand Binding Site [chemical binding]; other site
700598008864	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
700598008865	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598008866	FeS/SAM binding site; other site
700598008867	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
700598008868	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
700598008869	ThiS interaction site; other site
700598008870	putative active site [active]
700598008871	tetramer interface [polypeptide binding]; other site
700598008872	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
700598008873	thiamine phosphate binding site [chemical binding]; other site
700598008874	active site
700598008875	pyrophosphate binding site [ion binding]; other site
700598008876	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
700598008877	dimer interface [polypeptide binding]; other site
700598008878	substrate binding site [chemical binding]; other site
700598008879	ATP binding site [chemical binding]; other site
700598008880	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
700598008881	thiamine phosphate binding site [chemical binding]; other site
700598008882	active site
700598008883	pyrophosphate binding site [ion binding]; other site
700598008884	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
700598008885	ThiC-associated domain; Region: ThiC-associated; pfam13667
700598008886	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
700598008887	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
700598008888	thiS-thiF/thiG interaction site; other site
700598008889	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008890	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598008891	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
700598008892	N-terminal plug; other site
700598008893	ligand-binding site [chemical binding]; other site
700598008894	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598008895	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598008896	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598008897	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598008898	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
700598008899	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
700598008900	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598008901	bile acid transporter; Region: bass; TIGR00841
700598008902	Sodium Bile acid symporter family; Region: SBF; cl17470
700598008903	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
700598008904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
700598008905	Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
700598008906	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
700598008907	dimer interface [polypeptide binding]; other site
700598008908	active site
700598008909	catalytic residue [active]
700598008910	metal binding site [ion binding]; metal-binding site
700598008911	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700598008912	putative transporter; Provisional; Region: PRK10484
700598008913	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
700598008914	Na binding site [ion binding]; other site
700598008915	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598008916	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598008917	Right handed beta helix region; Region: Beta_helix; pfam13229
700598008918	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
700598008919	Abhydrolase family; Region: Abhydrolase_7; pfam12715
700598008920	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598008921	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
700598008922	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
700598008923	Na binding site [ion binding]; other site
700598008924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
700598008925	Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995
700598008926	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
700598008927	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700598008928	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
700598008929	inhibitor site; inhibition site
700598008930	active site
700598008931	dimer interface [polypeptide binding]; other site
700598008932	catalytic residue [active]
700598008933	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
700598008934	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
700598008935	putative active site [active]
700598008936	metal binding site [ion binding]; metal-binding site
700598008937	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
700598008938	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700598008939	BNR repeat-like domain; Region: BNR_2; pfam13088
700598008940	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
700598008941	catalytic site [active]
700598008942	Asp-box motif; other site
700598008943	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598008944	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598008945	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598008946	Trehalase; Region: Trehalase; cl17346
700598008947	BNR repeat-like domain; Region: BNR_2; pfam13088
700598008948	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
700598008949	active site
700598008950	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
700598008951	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
700598008952	Pectate lyase; Region: Pec_lyase_C; cl01593
700598008953	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598008954	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598008955	SusD family; Region: SusD; pfam07980
700598008956	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008957	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008958	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598008959	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598008960	Protein of unknown function (DUF3826); Region: DUF3826; pfam12875
700598008961	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
700598008962	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598008963	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598008964	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598008965	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
700598008966	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
700598008967	Pectate lyase; Region: Pec_lyase_C; cl01593
700598008968	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598008969	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598008970	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598008971	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
700598008972	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
700598008973	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598008974	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598008975	binding surface
700598008976	TPR motif; other site
700598008977	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598008978	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598008979	SusD family; Region: SusD; pfam07980
700598008980	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598008981	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598008982	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598008983	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598008984	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
700598008985	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598008986	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598008987	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
700598008988	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
700598008989	Amidohydrolase; Region: Amidohydro_2; pfam04909
700598008990	active site
700598008991	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700598008992	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700598008993	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700598008994	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700598008995	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
700598008996	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
700598008997	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700598008998	active site 2 [active]
700598008999	active site 1 [active]
700598009000	Phosphotransferase enzyme family; Region: APH; pfam01636
700598009001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598009002	glucose/galactose transporter; Region: gluP; TIGR01272
700598009003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598009004	ribulokinase; Provisional; Region: PRK04123
700598009005	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
700598009006	N- and C-terminal domain interface [polypeptide binding]; other site
700598009007	active site
700598009008	MgATP binding site [chemical binding]; other site
700598009009	catalytic site [active]
700598009010	metal binding site [ion binding]; metal-binding site
700598009011	carbohydrate binding site [chemical binding]; other site
700598009012	homodimer interface [polypeptide binding]; other site
700598009013	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
700598009014	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
700598009015	intersubunit interface [polypeptide binding]; other site
700598009016	active site
700598009017	Zn2+ binding site [ion binding]; other site
700598009018	L-arabinose isomerase; Provisional; Region: PRK02929
700598009019	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
700598009020	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
700598009021	trimer interface [polypeptide binding]; other site
700598009022	putative substrate binding site [chemical binding]; other site
700598009023	putative metal binding site [ion binding]; other site
700598009024	Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325
700598009025	putative transporter; Provisional; Region: PRK10484
700598009026	Na binding site [ion binding]; other site
700598009027	substrate binding site [chemical binding]; other site
700598009028	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
700598009029	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598009030	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598009031	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598009032	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
700598009033	active site
700598009034	catalytic triad [active]
700598009035	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
700598009036	metal binding site [ion binding]; metal-binding site
700598009037	active site
700598009038	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
700598009039	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
700598009040	active site
700598009041	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
700598009042	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700598009043	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
700598009044	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598009045	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598009046	dimer interface [polypeptide binding]; other site
700598009047	phosphorylation site [posttranslational modification]
700598009048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598009049	ATP binding site [chemical binding]; other site
700598009050	Mg2+ binding site [ion binding]; other site
700598009051	G-X-G motif; other site
700598009052	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
700598009053	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700598009054	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
700598009055	active site
700598009056	catalytic triad [active]
700598009057	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
700598009058	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700598009059	nucleotide binding site [chemical binding]; other site
700598009060	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
700598009061	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
700598009062	Domain of unknown function (DUF718); Region: DUF718; pfam05336
700598009063	short chain dehydrogenase; Validated; Region: PRK08324
700598009064	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
700598009065	active site
700598009066	Zn2+ binding site [ion binding]; other site
700598009067	intersubunit interface [polypeptide binding]; other site
700598009068	Herpesviridae UL52/UL70 DNA primase; Region: Herpes_UL52; cl17300
700598009069	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598009070	NAD(P) binding site [chemical binding]; other site
700598009071	active site
700598009072	rhamnose-proton symporter; Provisional; Region: PRK13499
700598009073	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598009074	DNA-binding site [nucleotide binding]; DNA binding site
700598009075	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
700598009076	putative dimerization interface [polypeptide binding]; other site
700598009077	putative ligand binding site [chemical binding]; other site
700598009078	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598009079	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
700598009080	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
700598009081	RES domain; Region: RES; pfam08808
700598009082	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598009083	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009084	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598009085	DNA binding residues [nucleotide binding]
700598009086	FecR protein; Region: FecR; pfam04773
700598009087	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598009088	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
700598009089	PLD-like domain; Region: PLDc_2; pfam13091
700598009090	putative active site [active]
700598009091	catalytic site [active]
700598009092	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
700598009093	PLD-like domain; Region: PLDc_2; pfam13091
700598009094	putative active site [active]
700598009095	catalytic site [active]
700598009096	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
700598009097	GntP family permease; Region: GntP_permease; pfam02447
700598009098	fructuronate transporter; Provisional; Region: PRK10034; cl15264
700598009099	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821
700598009100	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
700598009101	dimer interface [polypeptide binding]; other site
700598009102	active site
700598009103	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700598009104	substrate binding site [chemical binding]; other site
700598009105	catalytic residue [active]
700598009106	putative oxidoreductase; Provisional; Region: PRK11579
700598009107	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598009108	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700598009109	Cupin domain; Region: Cupin_2; pfam07883
700598009110	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
700598009111	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
700598009112	UbiA prenyltransferase family; Region: UbiA; pfam01040
700598009113	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
700598009114	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
700598009115	oligomer interface [polypeptide binding]; other site
700598009116	active site
700598009117	metal binding site [ion binding]; metal-binding site
700598009118	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
700598009119	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
700598009120	biotin synthase; Region: bioB; TIGR00433
700598009121	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598009122	FeS/SAM binding site; other site
700598009123	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
700598009124	Response regulator receiver domain; Region: Response_reg; pfam00072
700598009125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009126	active site
700598009127	phosphorylation site [posttranslational modification]
700598009128	intermolecular recognition site; other site
700598009129	dimerization interface [polypeptide binding]; other site
700598009130	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
700598009131	Found in ATP-dependent protease La (LON); Region: LON; smart00464
700598009132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598009133	Walker A motif; other site
700598009134	ATP binding site [chemical binding]; other site
700598009135	Walker B motif; other site
700598009136	arginine finger; other site
700598009137	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
700598009138	Protein of unknown function (DUF3276); Region: DUF3276; pfam11680
700598009139	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700598009140	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598009141	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598009142	Walker A/P-loop; other site
700598009143	ATP binding site [chemical binding]; other site
700598009144	Q-loop/lid; other site
700598009145	ABC transporter signature motif; other site
700598009146	Walker B; other site
700598009147	D-loop; other site
700598009148	H-loop/switch region; other site
700598009149	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
700598009150	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
700598009151	Ca binding site [ion binding]; other site
700598009152	active site
700598009153	catalytic site [active]
700598009154	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
700598009155	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
700598009156	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
700598009157	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
700598009158	putative ligand binding site [chemical binding]; other site
700598009159	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598009160	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598009161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598009162	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
700598009163	putative substrate translocation pore; other site
700598009164	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598009165	SusD family; Region: SusD; pfam07980
700598009166	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598009167	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009168	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598009169	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598009170	FecR protein; Region: FecR; pfam04773
700598009171	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598009172	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598009173	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009174	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598009175	DNA binding residues [nucleotide binding]
700598009176	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700598009177	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598009178	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
700598009179	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700598009180	MarR family; Region: MarR_2; cl17246
700598009181	H+ Antiporter protein; Region: 2A0121; TIGR00900
700598009182	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598009183	putative substrate translocation pore; other site
700598009184	Isochorismatase family; Region: Isochorismatase; pfam00857
700598009185	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
700598009186	catalytic triad [active]
700598009187	conserved cis-peptide bond; other site
700598009188	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
700598009189	Uncharacterized conserved protein [Function unknown]; Region: COG1262
700598009190	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
700598009191	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
700598009192	active site
700598009193	nucleophile elbow; other site
700598009194	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
700598009195	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598009196	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598009197	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598009198	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
700598009199	HAMP domain; Region: HAMP; pfam00672
700598009200	dimerization interface [polypeptide binding]; other site
700598009201	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700598009202	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598009203	GAF domain; Region: GAF; pfam01590
700598009204	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598009205	dimer interface [polypeptide binding]; other site
700598009206	phosphorylation site [posttranslational modification]
700598009207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598009208	ATP binding site [chemical binding]; other site
700598009209	Mg2+ binding site [ion binding]; other site
700598009210	G-X-G motif; other site
700598009211	Response regulator receiver domain; Region: Response_reg; pfam00072
700598009212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009213	active site
700598009214	phosphorylation site [posttranslational modification]
700598009215	intermolecular recognition site; other site
700598009216	dimerization interface [polypeptide binding]; other site
700598009217	Response regulator receiver domain; Region: Response_reg; pfam00072
700598009218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009219	active site
700598009220	phosphorylation site [posttranslational modification]
700598009221	intermolecular recognition site; other site
700598009222	dimerization interface [polypeptide binding]; other site
700598009223	DNA topoisomerase III; Provisional; Region: PRK07726
700598009224	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
700598009225	active site
700598009226	putative interdomain interaction site [polypeptide binding]; other site
700598009227	putative metal-binding site [ion binding]; other site
700598009228	putative nucleotide binding site [chemical binding]; other site
700598009229	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
700598009230	domain I; other site
700598009231	DNA binding groove [nucleotide binding]
700598009232	phosphate binding site [ion binding]; other site
700598009233	domain II; other site
700598009234	domain III; other site
700598009235	nucleotide binding site [chemical binding]; other site
700598009236	catalytic site [active]
700598009237	domain IV; other site
700598009238	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
700598009239	bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019
700598009240	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
700598009241	active site
700598009242	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598009243	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598009244	Active site serine [active]
700598009245	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598009246	Active site serine [active]
700598009247	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598009248	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
700598009249	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
700598009250	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
700598009251	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
700598009252	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
700598009253	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598009254	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009255	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598009256	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
700598009257	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598009258	short chain dehydrogenase; Provisional; Region: PRK08251
700598009259	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598009260	NAD(P) binding site [chemical binding]; other site
700598009261	active site
700598009262	Protein of unknown function (DUF3826); Region: DUF3826; pfam12875
700598009263	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598009264	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598009265	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598009266	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
700598009267	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
700598009268	putative NAD(P) binding site [chemical binding]; other site
700598009269	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
700598009270	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
700598009271	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
700598009272	active site
700598009273	catalytic site [active]
700598009274	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
700598009275	Uncharacterized conserved protein [Function unknown]; Region: COG5361
700598009276	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
700598009277	Domain of unknown function (DUF202); Region: DUF202; pfam02656
700598009278	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
700598009279	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
700598009280	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
700598009281	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
700598009282	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
700598009283	Uncharacterized conserved protein [Function unknown]; Region: COG1262
700598009284	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700598009285	Sulfatase; Region: Sulfatase; pfam00884
700598009286	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700598009287	Sulfatase; Region: Sulfatase; pfam00884
700598009288	Transposase; Region: HTH_Tnp_1; pfam01527
700598009289	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598009290	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009291	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598009292	DNA binding residues [nucleotide binding]
700598009293	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
700598009294	intracellular protease, PfpI family; Region: PfpI; TIGR01382
700598009295	proposed catalytic triad [active]
700598009296	conserved cys residue [active]
700598009297	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
700598009298	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
700598009299	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598009300	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598009301	ligand binding site [chemical binding]; other site
700598009302	flexible hinge region; other site
700598009303	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
700598009304	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
700598009305	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598009306	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700598009307	Sulfatase; Region: Sulfatase; cl17466
700598009308	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700598009309	Sulfatase; Region: Sulfatase; pfam00884
700598009310	Domain of unknown function (DUF718); Region: DUF718; pfam05336
700598009311	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
700598009312	putative transporter; Provisional; Region: PRK10484
700598009313	Na binding site [ion binding]; other site
700598009314	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
700598009315	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
700598009316	metal binding site [ion binding]; metal-binding site
700598009317	substrate binding pocket [chemical binding]; other site
700598009318	short chain dehydrogenase; Provisional; Region: PRK06172
700598009319	classical (c) SDRs; Region: SDR_c; cd05233
700598009320	NAD(P) binding site [chemical binding]; other site
700598009321	active site
700598009322	Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994
700598009323	active site
700598009324	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598009325	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598009326	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598009327	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598009328	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598009329	SusD family; Region: SusD; pfam07980
700598009330	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
700598009331	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598009332	ligand binding site [chemical binding]; other site
700598009333	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598009334	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598009335	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
700598009336	putative transporter; Provisional; Region: PRK10484
700598009337	Na binding site [ion binding]; other site
700598009338	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
700598009339	classical (c) SDRs; Region: SDR_c; cd05233
700598009340	NAD(P) binding site [chemical binding]; other site
700598009341	active site
700598009342	galactonate dehydratase; Provisional; Region: PRK14017
700598009343	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
700598009344	metal binding site [ion binding]; metal-binding site
700598009345	substrate binding pocket [chemical binding]; other site
700598009346	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
700598009347	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700598009348	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598009349	catalytic residue [active]
700598009350	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
700598009351	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
700598009352	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
700598009353	Cytochrome c; Region: Cytochrom_C; pfam00034
700598009354	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598009355	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598009356	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009357	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598009358	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598009359	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
700598009360	Strictosidine synthase; Region: Str_synth; pfam03088
700598009361	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
700598009362	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598009363	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598009364	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598009365	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598009366	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
700598009367	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
700598009368	metal binding site [ion binding]; metal-binding site
700598009369	dimer interface [polypeptide binding]; other site
700598009370	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700598009371	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
700598009372	inhibitor site; inhibition site
700598009373	active site
700598009374	dimer interface [polypeptide binding]; other site
700598009375	catalytic residue [active]
700598009376	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598009377	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598009378	NAD(P) binding site [chemical binding]; other site
700598009379	active site
700598009380	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
700598009381	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
700598009382	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700598009383	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598009384	DNA-binding site [nucleotide binding]; DNA binding site
700598009385	FCD domain; Region: FCD; pfam07729
700598009386	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598009387	TPR motif; other site
700598009388	binding surface
700598009389	TPR repeat; Region: TPR_11; pfam13414
700598009390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598009391	binding surface
700598009392	TPR motif; other site
700598009393	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
700598009394	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
700598009395	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
700598009396	putative active site [active]
700598009397	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598009398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598009399	Walker A/P-loop; other site
700598009400	ATP binding site [chemical binding]; other site
700598009401	Q-loop/lid; other site
700598009402	ABC transporter signature motif; other site
700598009403	Walker B; other site
700598009404	D-loop; other site
700598009405	H-loop/switch region; other site
700598009406	Trm112p-like protein; Region: Trm112p; cl01066
700598009407	N2227-like protein; Region: N2227; pfam07942
700598009408	Methyltransferase domain; Region: Methyltransf_11; pfam08241
700598009409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598009410	S-adenosylmethionine binding site [chemical binding]; other site
700598009411	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598009412	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598009413	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598009414	Tetratricopeptide repeat; Region: TPR_16; pfam13432
700598009415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598009416	binding surface
700598009417	TPR motif; other site
700598009418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598009419	binding surface
700598009420	TPR motif; other site
700598009421	TPR repeat; Region: TPR_11; pfam13414
700598009422	TIR domain; Region: TIR_2; pfam13676
700598009423	Domain of unknown function (DUF4071); Region: DUF4071; pfam13281
700598009424	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
700598009425	active site
700598009426	nucleophile elbow; other site
700598009427	putative alpha-glucosidase; Provisional; Region: PRK10658
700598009428	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
700598009429	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
700598009430	trimer interface [polypeptide binding]; other site
700598009431	active site
700598009432	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
700598009433	catalytic site [active]
700598009434	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
700598009435	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
700598009436	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
700598009437	active site
700598009438	catalytic site [active]
700598009439	SusE outer membrane protein; Region: SusE; pfam14292
700598009440	Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967
700598009441	starch binding site [chemical binding]; other site
700598009442	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
700598009443	starch binding site [chemical binding]; other site
700598009444	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598009445	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598009446	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009447	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598009448	pullulanase, type I; Region: pulA_typeI; TIGR02104
700598009449	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
700598009450	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
700598009451	Ca binding site [ion binding]; other site
700598009452	active site
700598009453	catalytic site [active]
700598009454	RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]; Region: COG0478
700598009455	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700598009456	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
700598009457	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598009458	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598009459	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009460	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598009461	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598009462	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598009463	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
700598009464	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
700598009465	active site
700598009466	Zn binding site [ion binding]; other site
700598009467	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598009468	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598009469	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598009470	SusD family; Region: SusD; pfam07980
700598009471	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009472	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598009473	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598009474	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598009475	potential frameshift: common BLAST hit: gi|255530419|ref|YP_003090791.1| response regulator receiver
700598009476	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598009477	Two component regulator propeller; Region: Reg_prop; pfam07494
700598009478	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598009479	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598009480	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598009481	dimer interface [polypeptide binding]; other site
700598009482	phosphorylation site [posttranslational modification]
700598009483	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598009484	ATP binding site [chemical binding]; other site
700598009485	Mg2+ binding site [ion binding]; other site
700598009486	G-X-G motif; other site
700598009487	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598009488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009489	active site
700598009490	phosphorylation site [posttranslational modification]
700598009491	intermolecular recognition site; other site
700598009492	dimerization interface [polypeptide binding]; other site
700598009493	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700598009494	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700598009495	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
700598009496	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598009497	putative catalytic residues [active]
700598009498	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
700598009499	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598009500	catalytic residues [active]
700598009501	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
700598009502	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598009503	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598009504	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
700598009505	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700598009506	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
700598009507	NRDE protein; Region: NRDE; cl01315
700598009508	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700598009509	phosphoenolpyruvate synthase; Validated; Region: PRK06464
700598009510	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
700598009511	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
700598009512	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
700598009513	YcxB-like protein; Region: YcxB; pfam14317
700598009514	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700598009515	Sulfatase; Region: Sulfatase; pfam00884
700598009516	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
700598009517	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598009518	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
700598009519	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598009520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598009521	dimer interface [polypeptide binding]; other site
700598009522	phosphorylation site [posttranslational modification]
700598009523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598009524	ATP binding site [chemical binding]; other site
700598009525	Mg2+ binding site [ion binding]; other site
700598009526	G-X-G motif; other site
700598009527	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598009528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009529	active site
700598009530	phosphorylation site [posttranslational modification]
700598009531	intermolecular recognition site; other site
700598009532	dimerization interface [polypeptide binding]; other site
700598009533	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
700598009534	DNA binding site [nucleotide binding]
700598009535	short chain dehydrogenase; Validated; Region: PRK06182
700598009536	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598009537	NADP binding site [chemical binding]; other site
700598009538	active site
700598009539	steroid binding site; other site
700598009540	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598009541	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598009542	von Willebrand factor type A domain; Region: VWA_2; pfam13519
700598009543	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
700598009544	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
700598009545	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
700598009546	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
700598009547	PLD-like domain; Region: PLDc_2; pfam13091
700598009548	putative homodimer interface [polypeptide binding]; other site
700598009549	putative active site [active]
700598009550	catalytic site [active]
700598009551	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598009552	AAA domain; Region: AAA_21; pfam13304
700598009553	Walker A/P-loop; other site
700598009554	ATP binding site [chemical binding]; other site
700598009555	AAA domain; Region: AAA_21; pfam13304
700598009556	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
700598009557	putative active site [active]
700598009558	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
700598009559	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
700598009560	dimer interface [polypeptide binding]; other site
700598009561	ssDNA binding site [nucleotide binding]; other site
700598009562	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700598009563	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
700598009564	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598009565	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598009566	Thioesterase domain; Region: Thioesterase; pfam00975
700598009567	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
700598009568	classical (c) SDRs; Region: SDR_c; cd05233
700598009569	NAD(P) binding site [chemical binding]; other site
700598009570	active site
700598009571	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598009572	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009573	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598009574	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700598009575	active site
700598009576	DNA binding site [nucleotide binding]
700598009577	Int/Topo IB signature motif; other site
700598009578	Predicted ATPase [General function prediction only]; Region: COG3911
700598009579	AAA domain; Region: AAA_28; pfam13521
700598009580	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598009581	TAP-like protein; Region: Abhydrolase_4; pfam08386
700598009582	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
700598009583	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598009584	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598009585	NAD(P) binding site [chemical binding]; other site
700598009586	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
700598009587	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598009588	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598009589	active site
700598009590	catalytic tetrad [active]
700598009591	Predicted amidohydrolase [General function prediction only]; Region: COG0388
700598009592	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585
700598009593	putative active site [active]
700598009594	catalytic triad [active]
700598009595	putative dimer interface [polypeptide binding]; other site
700598009596	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598009597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598009598	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598009599	Coenzyme A binding pocket [chemical binding]; other site
700598009600	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700598009601	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598009602	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009603	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598009604	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598009605	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700598009606	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700598009607	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700598009608	Reprolysin family propeptide; Region: Pep_M12B_propep; pfam01562
700598009609	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
700598009610	active site
700598009611	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598009612	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598009613	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598009614	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700598009615	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
700598009616	YCII-related domain; Region: YCII; cl00999
700598009617	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598009618	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009619	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598009620	Uncharacterized conserved protein [Function unknown]; Region: COG3189
700598009621	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598009622	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598009623	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598009624	Response regulator receiver domain; Region: Response_reg; pfam00072
700598009625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009626	active site
700598009627	phosphorylation site [posttranslational modification]
700598009628	intermolecular recognition site; other site
700598009629	dimerization interface [polypeptide binding]; other site
700598009630	Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519
700598009631	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598009632	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598009633	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598009634	ligand binding site [chemical binding]; other site
700598009635	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
700598009636	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
700598009637	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598009638	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598009639	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598009640	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598009641	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598009642	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
700598009643	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
700598009644	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598009645	Domain of unknown function (DUF4302); Region: DUF4302; pfam14135
700598009646	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598009647	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598009648	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009649	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598009650	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598009651	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598009652	FecR protein; Region: FecR; pfam04773
700598009653	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598009654	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598009655	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009656	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598009657	DNA binding residues [nucleotide binding]
700598009658	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598009659	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009660	tellurium resistance terB-like protein; Region: terB_like; cd07177
700598009661	metal binding site [ion binding]; metal-binding site
700598009662	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
700598009663	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
700598009664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
700598009665	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700598009666	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700598009667	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700598009668	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
700598009669	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
700598009670	Uncharacterized conserved protein [Function unknown]; Region: COG3379
700598009671	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
700598009672	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
700598009673	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
700598009674	PhoH-like protein; Region: PhoH; pfam02562
700598009675	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
700598009676	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
700598009677	dimer interface [polypeptide binding]; other site
700598009678	substrate binding site [chemical binding]; other site
700598009679	metal binding sites [ion binding]; metal-binding site
700598009680	DinB family; Region: DinB; cl17821
700598009681	DinB superfamily; Region: DinB_2; pfam12867
700598009682	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
700598009683	NlpC/P60 family; Region: NLPC_P60; pfam00877
700598009684	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598009685	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009686	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598009687	DNA binding residues [nucleotide binding]
700598009688	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
700598009689	nucleoside/Zn binding site; other site
700598009690	dimer interface [polypeptide binding]; other site
700598009691	catalytic motif [active]
700598009692	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
700598009693	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
700598009694	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
700598009695	Zn binding site [ion binding]; other site
700598009696	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700598009697	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
700598009698	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
700598009699	active site
700598009700	dimer interface [polypeptide binding]; other site
700598009701	catalytic nucleophile [active]
700598009702	Predicted acyl esterases [General function prediction only]; Region: COG2936
700598009703	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
700598009704	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
700598009705	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
700598009706	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
700598009707	active site
700598009708	glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122
700598009709	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
700598009710	active site
700598009711	trimer interface [polypeptide binding]; other site
700598009712	allosteric site; other site
700598009713	active site lid [active]
700598009714	hexamer (dimer of trimers) interface [polypeptide binding]; other site
700598009715	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
700598009716	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598009717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009718	active site
700598009719	phosphorylation site [posttranslational modification]
700598009720	intermolecular recognition site; other site
700598009721	dimerization interface [polypeptide binding]; other site
700598009722	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598009723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009724	active site
700598009725	phosphorylation site [posttranslational modification]
700598009726	intermolecular recognition site; other site
700598009727	dimerization interface [polypeptide binding]; other site
700598009728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598009729	dimer interface [polypeptide binding]; other site
700598009730	phosphorylation site [posttranslational modification]
700598009731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598009732	ATP binding site [chemical binding]; other site
700598009733	Mg2+ binding site [ion binding]; other site
700598009734	G-X-G motif; other site
700598009735	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
700598009736	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009737	dimerization interface [polypeptide binding]; other site
700598009738	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
700598009739	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009740	dimerization interface [polypeptide binding]; other site
700598009741	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009742	dimerization interface [polypeptide binding]; other site
700598009743	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009744	dimerization interface [polypeptide binding]; other site
700598009745	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
700598009746	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009747	dimerization interface [polypeptide binding]; other site
700598009748	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009749	dimerization interface [polypeptide binding]; other site
700598009750	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009751	dimerization interface [polypeptide binding]; other site
700598009752	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
700598009753	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009754	dimerization interface [polypeptide binding]; other site
700598009755	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009756	dimerization interface [polypeptide binding]; other site
700598009757	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009758	dimerization interface [polypeptide binding]; other site
700598009759	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598009760	dimerization interface [polypeptide binding]; other site
700598009761	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700598009762	GAF domain; Region: GAF_3; pfam13492
700598009763	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598009764	dimer interface [polypeptide binding]; other site
700598009765	phosphorylation site [posttranslational modification]
700598009766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598009767	ATP binding site [chemical binding]; other site
700598009768	Mg2+ binding site [ion binding]; other site
700598009769	G-X-G motif; other site
700598009770	Response regulator receiver domain; Region: Response_reg; pfam00072
700598009771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009772	active site
700598009773	phosphorylation site [posttranslational modification]
700598009774	intermolecular recognition site; other site
700598009775	dimerization interface [polypeptide binding]; other site
700598009776	Response regulator receiver domain; Region: Response_reg; pfam00072
700598009777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009778	active site
700598009779	phosphorylation site [posttranslational modification]
700598009780	intermolecular recognition site; other site
700598009781	Response regulator receiver domain; Region: Response_reg; pfam00072
700598009782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009783	active site
700598009784	phosphorylation site [posttranslational modification]
700598009785	intermolecular recognition site; other site
700598009786	dimerization interface [polypeptide binding]; other site
700598009787	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
700598009788	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598009789	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598009790	FecR protein; Region: FecR; pfam04773
700598009791	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598009792	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009793	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598009794	DNA binding residues [nucleotide binding]
700598009795	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598009796	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009797	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598009798	DNA binding residues [nucleotide binding]
700598009799	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598009800	FecR protein; Region: FecR; pfam04773
700598009801	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598009802	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598009803	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
700598009804	Transposase; Region: DEDD_Tnp_IS110; pfam01548
700598009805	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
700598009806	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
700598009807	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
700598009808	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700598009809	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598009810	non-specific DNA binding site [nucleotide binding]; other site
700598009811	salt bridge; other site
700598009812	sequence-specific DNA binding site [nucleotide binding]; other site
700598009813	HEPN domain; Region: HEPN; pfam05168
700598009814	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
700598009815	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700598009816	P-loop; other site
700598009817	Magnesium ion binding site [ion binding]; other site
700598009818	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700598009819	Magnesium ion binding site [ion binding]; other site
700598009820	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
700598009821	Protein of unknown function (DUF499); Region: DUF499; pfam04465
700598009822	Fn3 associated; Region: Fn3_assoc; pfam13287
700598009823	Protein of unknown function (DUF3780); Region: DUF3780; pfam12635
700598009824	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
700598009825	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
700598009826	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
700598009827	PLD-like domain; Region: PLDc_2; pfam13091
700598009828	putative active site [active]
700598009829	catalytic site [active]
700598009830	DEAD-like helicases superfamily; Region: DEXDc; smart00487
700598009831	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
700598009832	ATP binding site [chemical binding]; other site
700598009833	putative Mg++ binding site [ion binding]; other site
700598009834	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598009835	nucleotide binding region [chemical binding]; other site
700598009836	ATP-binding site [chemical binding]; other site
700598009837	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
700598009838	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
700598009839	CHC2 zinc finger; Region: zf-CHC2; cl17510
700598009840	Toprim-like; Region: Toprim_2; pfam13155
700598009841	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598009842	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
700598009843	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598009844	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
700598009845	active site
700598009846	CAAX protease self-immunity; Region: Abi; pfam02517
700598009847	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
700598009848	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598009849	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598009850	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598009851	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009852	Clp protease; Region: CLP_protease; pfam00574
700598009853	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
700598009854	oligomer interface [polypeptide binding]; other site
700598009855	active site residues [active]
700598009856	Fasciclin domain; Region: Fasciclin; cl02663
700598009857	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598009858	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598009859	SusD family; Region: SusD; pfam07980
700598009860	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009861	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598009862	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598009863	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
700598009864	Bacterial PH domain; Region: DUF304; pfam03703
700598009865	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598009866	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598009867	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598009868	DNA binding residues [nucleotide binding]
700598009869	FecR protein; Region: FecR; pfam04773
700598009870	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598009871	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009872	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598009873	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598009874	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598009875	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598009876	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598009877	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598009878	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
700598009879	active site
700598009880	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
700598009881	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
700598009882	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700598009883	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598009884	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598009885	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700598009886	FAD binding domain; Region: FAD_binding_3; pfam01494
700598009887	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
700598009888	catalytic core [active]
700598009889	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598009890	Uncharacterized conserved protein [Function unknown]; Region: COG3391
700598009891	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
700598009892	Nitroreductase family; Region: Nitroreductase; pfam00881
700598009893	FMN binding site [chemical binding]; other site
700598009894	dimer interface [polypeptide binding]; other site
700598009895	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
700598009896	BON domain; Region: BON; pfam04972
700598009897	BON domain; Region: BON; pfam04972
700598009898	SnoaL-like domain; Region: SnoaL_2; pfam12680
700598009899	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
700598009900	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598009901	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598009902	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598009903	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
700598009904	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598009905	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
700598009906	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598009907	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598009908	Outer membrane efflux protein; Region: OEP; pfam02321
700598009909	Outer membrane efflux protein; Region: OEP; pfam02321
700598009910	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700598009911	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700598009912	Walker A/P-loop; other site
700598009913	ATP binding site [chemical binding]; other site
700598009914	Q-loop/lid; other site
700598009915	ABC transporter signature motif; other site
700598009916	Walker B; other site
700598009917	D-loop; other site
700598009918	H-loop/switch region; other site
700598009919	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598009920	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598009921	FtsX-like permease family; Region: FtsX; pfam02687
700598009922	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598009923	FtsX-like permease family; Region: FtsX; pfam02687
700598009924	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
700598009925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598009926	active site
700598009927	phosphorylation site [posttranslational modification]
700598009928	intermolecular recognition site; other site
700598009929	dimerization interface [polypeptide binding]; other site
700598009930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598009931	Walker A motif; other site
700598009932	ATP binding site [chemical binding]; other site
700598009933	Walker B motif; other site
700598009934	arginine finger; other site
700598009935	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
700598009936	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
700598009937	dimerization interface [polypeptide binding]; other site
700598009938	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
700598009939	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598009940	putative active site [active]
700598009941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598009942	ATP binding site [chemical binding]; other site
700598009943	Mg2+ binding site [ion binding]; other site
700598009944	G-X-G motif; other site
700598009945	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598009946	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598009947	FtsX-like permease family; Region: FtsX; pfam02687
700598009948	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598009949	FtsX-like permease family; Region: FtsX; pfam02687
700598009950	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598009951	binding surface
700598009952	TPR motif; other site
700598009953	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598009954	binding surface
700598009955	TPR motif; other site
700598009956	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
700598009957	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
700598009958	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
700598009959	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
700598009960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
700598009961	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598009962	active site
700598009963	phosphorylation site [posttranslational modification]
700598009964	intermolecular recognition site; other site
700598009965	dimerization interface [polypeptide binding]; other site
700598009966	LytTr DNA-binding domain; Region: LytTR; smart00850
700598009967	Cytochrome c; Region: Cytochrom_C; pfam00034
700598009968	YceI-like domain; Region: YceI; pfam04264
700598009969	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700598009970	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
700598009971	KWG Leptospira; Region: KWG; pfam07656
700598009972	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
700598009973	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598009974	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
700598009975	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700598009976	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598009977	Walker A/P-loop; other site
700598009978	ATP binding site [chemical binding]; other site
700598009979	Q-loop/lid; other site
700598009980	ABC transporter signature motif; other site
700598009981	Walker B; other site
700598009982	D-loop; other site
700598009983	H-loop/switch region; other site
700598009984	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
700598009985	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598009986	FtsX-like permease family; Region: FtsX; pfam02687
700598009987	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598009988	FtsX-like permease family; Region: FtsX; pfam02687
700598009989	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
700598009990	active site
700598009991	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598009992	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598009993	catalytic residues [active]
700598009994	glycerol kinase-like protein; Provisional; Region: PTZ00294
700598009995	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598009996	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598009997	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598009998	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598009999	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010000	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598010001	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598010002	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598010003	FecR protein; Region: FecR; pfam04773
700598010004	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598010005	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598010006	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598010007	DNA binding residues [nucleotide binding]
700598010008	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598010009	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598010010	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598010011	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598010012	Outer membrane efflux protein; Region: OEP; pfam02321
700598010013	Outer membrane efflux protein; Region: OEP; pfam02321
700598010014	Hemerythrin-like domain; Region: Hr-like; cd12108
700598010015	Fe binding site [ion binding]; other site
700598010016	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
700598010017	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598010018	active site
700598010019	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598010020	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598010021	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598010022	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598010023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
700598010024	active site
700598010025	dimerization interface [polypeptide binding]; other site
700598010026	LytTr DNA-binding domain; Region: LytTR; smart00850
700598010027	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598010028	putative DNA binding site [nucleotide binding]; other site
700598010029	dimerization interface [polypeptide binding]; other site
700598010030	putative Zn2+ binding site [ion binding]; other site
700598010031	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598010032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598010033	S-adenosylmethionine binding site [chemical binding]; other site
700598010034	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
700598010035	amphipathic channel; other site
700598010036	Asn-Pro-Ala signature motifs; other site
700598010037	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
700598010038	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598010039	active site
700598010040	metal binding site [ion binding]; metal-binding site
700598010041	RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637
700598010042	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598010043	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598010044	DNA binding residues [nucleotide binding]
700598010045	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
700598010046	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700598010047	active site
700598010048	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
700598010049	active site
700598010050	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598010051	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598010052	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598010053	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598010054	DNA binding residues [nucleotide binding]
700598010055	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598010056	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010057	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
700598010058	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598010059	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598010060	Domain of unknown function (DUF4302); Region: DUF4302; pfam14135
700598010061	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
700598010062	S1 domain; Region: S1_2; pfam13509
700598010063	Peptidase family S41; Region: Peptidase_S41; pfam03572
700598010064	Active site serine [active]
700598010065	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
700598010066	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598010067	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598010068	catalytic residues [active]
700598010069	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598010070	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598010071	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598010072	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598010073	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010074	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598010075	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598010076	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598010077	FecR protein; Region: FecR; pfam04773
700598010078	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598010079	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598010080	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598010081	DNA binding residues [nucleotide binding]
700598010082	Alginate lyase; Region: Alginate_lyase2; pfam08787
700598010083	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598010084	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598010085	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598010086	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598010087	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598010088	catalytic residues [active]
700598010089	Protein of unknown function (DUF3738); Region: DUF3738; cl11887
700598010090	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598010091	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598010092	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598010093	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598010094	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010095	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598010096	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598010097	FecR protein; Region: FecR; pfam04773
700598010098	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598010099	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598010100	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598010101	DNA binding residues [nucleotide binding]
700598010102	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
700598010103	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598010104	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598010105	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598010106	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
700598010107	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
700598010108	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700598010109	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598010110	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598010111	ligand binding site [chemical binding]; other site
700598010112	flexible hinge region; other site
700598010113	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598010114	dimerization interface [polypeptide binding]; other site
700598010115	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
700598010116	PAS domain; Region: PAS; smart00091
700598010117	putative active site [active]
700598010118	heme pocket [chemical binding]; other site
700598010119	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598010120	dimer interface [polypeptide binding]; other site
700598010121	phosphorylation site [posttranslational modification]
700598010122	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598010123	ATP binding site [chemical binding]; other site
700598010124	Mg2+ binding site [ion binding]; other site
700598010125	G-X-G motif; other site
700598010126	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
700598010127	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
700598010128	Ligand Binding Site [chemical binding]; other site
700598010129	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
700598010130	K+-transporting ATPase, c chain; Region: KdpC; cl00944
700598010131	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
700598010132	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700598010133	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700598010134	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
700598010135	K+ potassium transporter; Region: K_trans; pfam02705
700598010136	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
700598010137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598010138	active site
700598010139	phosphorylation site [posttranslational modification]
700598010140	intermolecular recognition site; other site
700598010141	dimerization interface [polypeptide binding]; other site
700598010142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598010143	Walker A motif; other site
700598010144	ATP binding site [chemical binding]; other site
700598010145	Walker B motif; other site
700598010146	arginine finger; other site
700598010147	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
700598010148	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
700598010149	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
700598010150	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
700598010151	Ligand Binding Site [chemical binding]; other site
700598010152	TilS substrate C-terminal domain; Region: TilS_C; smart00977
700598010153	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598010154	binding surface
700598010155	Tetratricopeptide repeat; Region: TPR_16; pfam13432
700598010156	TPR motif; other site
700598010157	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
700598010158	Ligand binding site [chemical binding]; other site
700598010159	Electron transfer flavoprotein domain; Region: ETF; pfam01012
700598010160	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
700598010161	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
700598010162	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
700598010163	Bifunctional nuclease; Region: DNase-RNase; pfam02577
700598010164	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
700598010165	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
700598010166	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
700598010167	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700598010168	inhibitor-cofactor binding pocket; inhibition site
700598010169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598010170	catalytic residue [active]
700598010171	CCC1-related family of proteins; Region: CCC1_like; cl00278
700598010172	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
700598010173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598010174	putative substrate translocation pore; other site
700598010175	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
700598010176	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598010177	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598010178	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598010179	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598010180	Outer membrane efflux protein; Region: OEP; pfam02321
700598010181	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
700598010182	SnoaL-like domain; Region: SnoaL_2; pfam12680
700598010183	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598010184	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598010185	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
700598010186	active site
700598010187	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598010188	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598010189	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010190	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598010191	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598010192	FecR protein; Region: FecR; pfam04773
700598010193	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598010194	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598010195	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598010196	DNA binding residues [nucleotide binding]
700598010197	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598010198	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010199	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598010200	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598010201	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598010202	Response regulator receiver domain; Region: Response_reg; pfam00072
700598010203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598010204	active site
700598010205	phosphorylation site [posttranslational modification]
700598010206	intermolecular recognition site; other site
700598010207	dimerization interface [polypeptide binding]; other site
700598010208	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598010209	dimerization interface [polypeptide binding]; other site
700598010210	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598010211	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598010212	dimer interface [polypeptide binding]; other site
700598010213	phosphorylation site [posttranslational modification]
700598010214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598010215	ATP binding site [chemical binding]; other site
700598010216	Mg2+ binding site [ion binding]; other site
700598010217	G-X-G motif; other site
700598010218	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
700598010219	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598010220	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598010221	Response regulator receiver domain; Region: Response_reg; pfam00072
700598010222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598010223	active site
700598010224	phosphorylation site [posttranslational modification]
700598010225	intermolecular recognition site; other site
700598010226	dimerization interface [polypeptide binding]; other site
700598010227	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
700598010228	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
700598010229	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
700598010230	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
700598010231	Hemerythrin-like domain; Region: Hr-like; cd12108
700598010232	Fe binding site [ion binding]; other site
700598010233	Rrf2 family protein; Region: rrf2_super; TIGR00738
700598010234	Transcriptional regulator; Region: Rrf2; pfam02082
700598010235	Epoxide hydrolase N terminus; Region: EHN; pfam06441
700598010236	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598010237	Protein of unknown function, DUF; Region: DUF411; cl01142
700598010238	Predicted membrane protein [Function unknown]; Region: COG2860
700598010239	UPF0126 domain; Region: UPF0126; pfam03458
700598010240	UPF0126 domain; Region: UPF0126; pfam03458
700598010241	hypothetical protein; Validated; Region: PRK00153
700598010242	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598010243	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598010244	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700598010245	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
700598010246	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
700598010247	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
700598010248	TrkA-N domain; Region: TrkA_N; pfam02254
700598010249	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700598010250	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
700598010251	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
700598010252	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700598010253	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
700598010254	active site
700598010255	FMN binding site [chemical binding]; other site
700598010256	substrate binding site [chemical binding]; other site
700598010257	homotetramer interface [polypeptide binding]; other site
700598010258	catalytic residue [active]
700598010259	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
700598010260	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598010261	putative DNA binding site [nucleotide binding]; other site
700598010262	putative Zn2+ binding site [ion binding]; other site
700598010263	AsnC family; Region: AsnC_trans_reg; pfam01037
700598010264	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
700598010265	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
700598010266	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598010267	catalytic residue [active]
700598010268	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598010269	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598010270	active site
700598010271	metal binding site [ion binding]; metal-binding site
700598010272	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598010273	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598010274	SusD family; Region: SusD; pfam07980
700598010275	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598010276	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598010277	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598010278	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
700598010279	FecR protein; Region: FecR; pfam04773
700598010280	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598010281	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598010282	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598010283	DNA binding residues [nucleotide binding]
700598010284	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
700598010285	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700598010286	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
700598010287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
700598010288	MOSC domain; Region: MOSC; pfam03473
700598010289	3-alpha domain; Region: 3-alpha; pfam03475
700598010290	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700598010291	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
700598010292	FAD binding pocket [chemical binding]; other site
700598010293	FAD binding motif [chemical binding]; other site
700598010294	phosphate binding motif [ion binding]; other site
700598010295	beta-alpha-beta structure motif; other site
700598010296	NAD binding pocket [chemical binding]; other site
700598010297	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598010298	catalytic loop [active]
700598010299	iron binding site [ion binding]; other site
700598010300	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700598010301	Zn2+ binding site [ion binding]; other site
700598010302	Mg2+ binding site [ion binding]; other site
700598010303	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
700598010304	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598010305	active site
700598010306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598010307	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
700598010308	putative substrate translocation pore; other site
700598010309	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
700598010310	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
700598010311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700598010312	dimer interface [polypeptide binding]; other site
700598010313	conserved gate region; other site
700598010314	putative PBP binding loops; other site
700598010315	ABC-ATPase subunit interface; other site
700598010316	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700598010317	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598010318	Walker A/P-loop; other site
700598010319	ATP binding site [chemical binding]; other site
700598010320	Q-loop/lid; other site
700598010321	ABC transporter signature motif; other site
700598010322	Walker B; other site
700598010323	D-loop; other site
700598010324	H-loop/switch region; other site
700598010325	mercuric reductase; Validated; Region: PRK06370
700598010326	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598010327	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700598010328	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
700598010329	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
700598010330	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
700598010331	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598010332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598010333	active site
700598010334	phosphorylation site [posttranslational modification]
700598010335	intermolecular recognition site; other site
700598010336	dimerization interface [polypeptide binding]; other site
700598010337	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598010338	DNA binding site [nucleotide binding]
700598010339	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
700598010340	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
700598010341	active site
700598010342	catalytic site [active]
700598010343	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
700598010344	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
700598010345	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
700598010346	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
700598010347	nudix motif; other site
700598010348	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
700598010349	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
700598010350	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010351	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598010352	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598010353	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598010354	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598010355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598010356	dimer interface [polypeptide binding]; other site
700598010357	phosphorylation site [posttranslational modification]
700598010358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
700598010359	G-X-G motif; other site
700598010360	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598010361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598010362	active site
700598010363	phosphorylation site [posttranslational modification]
700598010364	intermolecular recognition site; other site
700598010365	dimerization interface [polypeptide binding]; other site
700598010366	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598010367	DNA binding site [nucleotide binding]
700598010368	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598010369	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598010370	Histidine kinase; Region: His_kinase; pfam06580
700598010371	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598010372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598010373	active site
700598010374	phosphorylation site [posttranslational modification]
700598010375	intermolecular recognition site; other site
700598010376	dimerization interface [polypeptide binding]; other site
700598010377	LytTr DNA-binding domain; Region: LytTR; pfam04397
700598010378	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
700598010379	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598010380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598010381	active site
700598010382	phosphorylation site [posttranslational modification]
700598010383	intermolecular recognition site; other site
700598010384	dimerization interface [polypeptide binding]; other site
700598010385	LytTr DNA-binding domain; Region: LytTR; smart00850
700598010386	Histidine kinase; Region: His_kinase; pfam06580
700598010387	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
700598010388	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
700598010389	catalytic residue [active]
700598010390	metal binding site [ion binding]; metal-binding site
700598010391	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010392	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598010393	Uncharacterized conserved protein [Function unknown]; Region: COG3391
700598010394	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
700598010395	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598010396	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598010397	Outer membrane efflux protein; Region: OEP; pfam02321
700598010398	Outer membrane efflux protein; Region: OEP; pfam02321
700598010399	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598010400	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598010401	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598010402	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
700598010403	active site
700598010404	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700598010405	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
700598010406	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
700598010407	PYR/PP interface [polypeptide binding]; other site
700598010408	dimer interface [polypeptide binding]; other site
700598010409	TPP binding site [chemical binding]; other site
700598010410	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
700598010411	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
700598010412	TPP-binding site [chemical binding]; other site
700598010413	dimer interface [polypeptide binding]; other site
700598010414	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
700598010415	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
700598010416	TPP-binding site [chemical binding]; other site
700598010417	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
700598010418	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
700598010419	active site
700598010420	SUMO-1 interface [polypeptide binding]; other site
700598010421	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
700598010422	HlyD family secretion protein; Region: HlyD; pfam00529
700598010423	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598010424	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598010425	Outer membrane efflux protein; Region: OEP; pfam02321
700598010426	Outer membrane efflux protein; Region: OEP; pfam02321
700598010427	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598010428	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598010429	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598010430	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598010431	SusD family; Region: SusD; pfam07980
700598010432	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598010433	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598010434	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010435	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598010436	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598010437	FecR protein; Region: FecR; pfam04773
700598010438	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598010439	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598010440	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598010441	DNA binding residues [nucleotide binding]
700598010442	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
700598010443	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
700598010444	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
700598010445	YceI-like domain; Region: YceI; cl01001
700598010446	YceI-like domain; Region: YceI; pfam04264
700598010447	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598010448	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598010449	active site
700598010450	catalytic tetrad [active]
700598010451	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
700598010452	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598010453	SusD family; Region: SusD; pfam07980
700598010454	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598010455	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010456	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598010457	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598010458	CHAT domain; Region: CHAT; pfam12770
700598010459	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598010460	binding surface
700598010461	TPR motif; other site
700598010462	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
700598010463	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
700598010464	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
700598010465	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010466	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598010467	short chain dehydrogenase; Provisional; Region: PRK06500
700598010468	classical (c) SDRs; Region: SDR_c; cd05233
700598010469	NAD(P) binding site [chemical binding]; other site
700598010470	active site
700598010471	oxidoreductase; Provisional; Region: PRK06196
700598010472	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
700598010473	putative NAD(P) binding site [chemical binding]; other site
700598010474	active site
700598010475	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
700598010476	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
700598010477	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598010478	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598010479	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
700598010480	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598010481	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700598010482	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
700598010483	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598010484	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598010485	short chain dehydrogenase; Provisional; Region: PRK06500
700598010486	classical (c) SDRs; Region: SDR_c; cd05233
700598010487	NAD(P) binding site [chemical binding]; other site
700598010488	active site
700598010489	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
700598010490	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
700598010491	putative NAD(P) binding site [chemical binding]; other site
700598010492	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598010493	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598010494	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598010495	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598010496	NAD(P) binding site [chemical binding]; other site
700598010497	active site
700598010498	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
700598010499	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
700598010500	putative DNA binding site [nucleotide binding]; other site
700598010501	putative homodimer interface [polypeptide binding]; other site
700598010502	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598010503	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
700598010504	trimer interface [polypeptide binding]; other site
700598010505	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
700598010506	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598010507	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
700598010508	classical (c) SDRs; Region: SDR_c; cd05233
700598010509	NAD(P) binding site [chemical binding]; other site
700598010510	active site
700598010511	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598010512	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598010513	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598010514	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598010515	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598010516	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598010517	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598010518	Histidine kinase; Region: HisKA_3; pfam07730
700598010519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598010520	ATP binding site [chemical binding]; other site
700598010521	Mg2+ binding site [ion binding]; other site
700598010522	G-X-G motif; other site
700598010523	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
700598010524	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700598010525	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700598010526	Walker A/P-loop; other site
700598010527	ATP binding site [chemical binding]; other site
700598010528	Q-loop/lid; other site
700598010529	ABC transporter signature motif; other site
700598010530	Walker B; other site
700598010531	D-loop; other site
700598010532	H-loop/switch region; other site
700598010533	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
700598010534	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
700598010535	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
700598010536	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
700598010537	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
700598010538	putative dimer interface [polypeptide binding]; other site
700598010539	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
700598010540	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598010541	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598010542	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598010543	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
700598010544	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
700598010545	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
700598010546	Chromate transporter; Region: Chromate_transp; pfam02417
700598010547	DNA topoisomerase I; Validated; Region: PRK05582
700598010548	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
700598010549	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700598010550	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598010551	motif II; other site
700598010552	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
700598010553	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
700598010554	Multicopper oxidase; Region: Cu-oxidase; pfam00394
700598010555	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
700598010556	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
700598010557	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
700598010558	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
700598010559	putative dimer interface [polypeptide binding]; other site
700598010560	CheB methylesterase; Region: CheB_methylest; pfam01339
700598010561	Protein of unknown function (DUF342); Region: DUF342; pfam03961
700598010562	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
700598010563	Beta-propeller repeat; Region: SBBP; pfam06739
700598010564	Beta-propeller repeat; Region: SBBP; pfam06739
700598010565	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
700598010566	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
700598010567	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
700598010568	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
700598010569	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
700598010570	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
700598010571	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
700598010572	Cl binding site [ion binding]; other site
700598010573	oligomer interface [polypeptide binding]; other site
700598010574	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
700598010575	nudix motif; other site
700598010576	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598010577	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700598010578	Walker A/P-loop; other site
700598010579	ATP binding site [chemical binding]; other site
700598010580	Q-loop/lid; other site
700598010581	ABC transporter signature motif; other site
700598010582	Walker B; other site
700598010583	D-loop; other site
700598010584	H-loop/switch region; other site
700598010585	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
700598010586	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598010587	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
700598010588	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598010589	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
700598010590	active site
700598010591	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
700598010592	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
700598010593	B12 binding site [chemical binding]; other site
700598010594	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598010595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598010596	S-adenosylmethionine binding site [chemical binding]; other site
700598010597	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598010598	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
700598010599	FeS/SAM binding site; other site
700598010600	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
700598010601	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
700598010602	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598010603	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
700598010604	FeS/SAM binding site; other site
700598010605	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598010606	S-adenosylmethionine binding site [chemical binding]; other site
700598010607	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
700598010608	B12 binding domain; Region: B12-binding; pfam02310
700598010609	B12 binding site [chemical binding]; other site
700598010610	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598010611	FeS/SAM binding site; other site
700598010612	Bacterial sugar transferase; Region: Bac_transf; pfam02397
700598010613	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
700598010614	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
700598010615	putative phosphate acyltransferase; Provisional; Region: PRK05331
700598010616	CAAX protease self-immunity; Region: Abi; pfam02517
700598010617	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
700598010618	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
700598010619	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
700598010620	putative active site [active]
700598010621	putative metal binding site [ion binding]; other site
700598010622	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
700598010623	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
700598010624	HSP70 interaction site [polypeptide binding]; other site
700598010625	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598010626	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598010627	Amidohydrolase; Region: Amidohydro_4; pfam13147
700598010628	active site
700598010629	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700598010630	SnoaL-like domain; Region: SnoaL_3; pfam13474
700598010631	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
700598010632	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598010633	putative catalytic residue [active]
700598010634	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
700598010635	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
700598010636	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598010637	Walker A/P-loop; other site
700598010638	ATP binding site [chemical binding]; other site
700598010639	Q-loop/lid; other site
700598010640	ABC transporter signature motif; other site
700598010641	Walker B; other site
700598010642	D-loop; other site
700598010643	H-loop/switch region; other site
700598010644	ABC transporter; Region: ABC_tran_2; pfam12848
700598010645	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700598010646	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700598010647	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
700598010648	PA/protease or protease-like domain interface [polypeptide binding]; other site
700598010649	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
700598010650	Peptidase family M28; Region: Peptidase_M28; pfam04389
700598010651	metal binding site [ion binding]; metal-binding site
700598010652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598010653	S-adenosylmethionine binding site [chemical binding]; other site
700598010654	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598010655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598010656	putative substrate translocation pore; other site
700598010657	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
700598010658	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
700598010659	active site
700598010660	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
700598010661	catalytic residues [active]
700598010662	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
700598010663	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
700598010664	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
700598010665	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
700598010666	conserved hypothetical protein; Region: TIGR02231
700598010667	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
700598010668	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
700598010669	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598010670	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
700598010671	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
700598010672	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
700598010673	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
700598010674	FeoA domain; Region: FeoA; pfam04023
700598010675	manganese transport protein MntH; Reviewed; Region: PRK00701
700598010676	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
700598010677	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598010678	Ligand Binding Site [chemical binding]; other site
700598010679	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598010680	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598010681	ligand binding site [chemical binding]; other site
700598010682	flexible hinge region; other site
700598010683	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598010684	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598010685	ligand binding site [chemical binding]; other site
700598010686	flexible hinge region; other site
700598010687	isocitrate dehydrogenase; Validated; Region: PRK08299
700598010688	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
700598010689	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
700598010690	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
700598010691	active site
700598010692	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
700598010693	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598010694	Ligand Binding Site [chemical binding]; other site
700598010695	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598010696	Ligand Binding Site [chemical binding]; other site
700598010697	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700598010698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700598010699	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
700598010700	putative dimerization interface [polypeptide binding]; other site
700598010701	threonine synthase; Validated; Region: PRK08197
700598010702	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
700598010703	homodimer interface [polypeptide binding]; other site
700598010704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598010705	catalytic residue [active]
700598010706	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
700598010707	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
700598010708	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
700598010709	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
700598010710	putative active site; other site
700598010711	catalytic triad [active]
700598010712	putative dimer interface [polypeptide binding]; other site
700598010713	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
700598010714	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598010715	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598010716	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
700598010717	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598010718	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700598010719	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
700598010720	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
700598010721	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
700598010722	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
700598010723	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
700598010724	four helix bundle protein; Region: TIGR02436
700598010725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598010726	putative substrate translocation pore; other site
700598010727	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598010728	PAS fold; Region: PAS_4; pfam08448
700598010729	PAS domain S-box; Region: sensory_box; TIGR00229
700598010730	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598010731	putative active site [active]
700598010732	heme pocket [chemical binding]; other site
700598010733	PAS domain S-box; Region: sensory_box; TIGR00229
700598010734	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598010735	putative active site [active]
700598010736	heme pocket [chemical binding]; other site
700598010737	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598010738	Histidine kinase; Region: HisKA_3; pfam07730
700598010739	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598010740	ATP binding site [chemical binding]; other site
700598010741	Mg2+ binding site [ion binding]; other site
700598010742	G-X-G motif; other site
700598010743	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
700598010744	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700598010745	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598010746	motif II; other site
700598010747	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
700598010748	dimerization interface [polypeptide binding]; other site
700598010749	putative active cleft [active]
700598010750	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
700598010751	active site
700598010752	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
700598010753	Na binding site [ion binding]; other site
700598010754	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
700598010755	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598010756	SusD family; Region: SusD; pfam07980
700598010757	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598010758	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010759	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598010760	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598010761	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598010762	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598010763	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
700598010764	nudix motif; other site
700598010765	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
700598010766	beta-D-glucuronidase; Provisional; Region: PRK10150
700598010767	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598010768	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598010769	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598010770	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
700598010771	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598010772	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598010773	SusD family; Region: SusD; pfam07980
700598010774	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598010775	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598010776	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598010777	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598010778	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598010779	FecR protein; Region: FecR; pfam04773
700598010780	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598010781	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598010782	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598010783	DNA binding residues [nucleotide binding]
700598010784	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
700598010785	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700598010786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598010787	S-adenosylmethionine binding site [chemical binding]; other site
700598010788	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
700598010789	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598010790	TPR motif; other site
700598010791	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
700598010792	binding surface
700598010793	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598010794	binding surface
700598010795	TPR motif; other site
700598010796	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598010797	binding surface
700598010798	Tetratricopeptide repeat; Region: TPR_16; pfam13432
700598010799	TPR motif; other site
700598010800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598010801	TPR motif; other site
700598010802	binding surface
700598010803	DoxX; Region: DoxX; pfam07681
700598010804	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
700598010805	active site
700598010806	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
700598010807	competence damage-inducible protein A; Provisional; Region: PRK00549
700598010808	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
700598010809	putative MPT binding site; other site
700598010810	Competence-damaged protein; Region: CinA; pfam02464
700598010811	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
700598010812	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700598010813	E3 interaction surface; other site
700598010814	lipoyl attachment site [posttranslational modification]; other site
700598010815	e3 binding domain; Region: E3_binding; pfam02817
700598010816	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
700598010817	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700598010818	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598010819	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
700598010820	EamA-like transporter family; Region: EamA; pfam00892
700598010821	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
700598010822	Ligand binding site; other site
700598010823	Putative Catalytic site; other site
700598010824	DXD motif; other site
700598010825	exodeoxyribonuclease X; Provisional; Region: PRK07983
700598010826	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
700598010827	active site
700598010828	catalytic site [active]
700598010829	substrate binding site [chemical binding]; other site
700598010830	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
700598010831	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
700598010832	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700598010833	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700598010834	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598010835	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
700598010836	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700598010837	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598010838	active site
700598010839	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
700598010840	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598010841	catalytic residue [active]
700598010842	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
700598010843	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
700598010844	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700598010845	RNA binding surface [nucleotide binding]; other site
700598010846	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
700598010847	active site
700598010848	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
700598010849	active site
700598010850	catalytic residues [active]
700598010851	metal binding site [ion binding]; metal-binding site
700598010852	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
700598010853	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
700598010854	UbiA prenyltransferase family; Region: UbiA; pfam01040
700598010855	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
700598010856	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
700598010857	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
700598010858	MutS domain I; Region: MutS_I; pfam01624
700598010859	MutS domain II; Region: MutS_II; pfam05188
700598010860	MutS domain III; Region: MutS_III; pfam05192
700598010861	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
700598010862	Walker A/P-loop; other site
700598010863	ATP binding site [chemical binding]; other site
700598010864	Q-loop/lid; other site
700598010865	ABC transporter signature motif; other site
700598010866	Walker B; other site
700598010867	D-loop; other site
700598010868	H-loop/switch region; other site
700598010869	PA14 domain; Region: PA14; cl08459
700598010870	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598010871	Predicted membrane protein [Function unknown]; Region: COG3503
700598010872	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
700598010873	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
700598010874	N- and C-terminal domain interface [polypeptide binding]; other site
700598010875	active site
700598010876	catalytic site [active]
700598010877	metal binding site [ion binding]; metal-binding site
700598010878	carbohydrate binding site [chemical binding]; other site
700598010879	ATP binding site [chemical binding]; other site
700598010880	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
700598010881	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
700598010882	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598010883	catalytic residue [active]
700598010884	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
700598010885	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
700598010886	active site
700598010887	substrate binding site [chemical binding]; other site
700598010888	metal binding site [ion binding]; metal-binding site
700598010889	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700598010890	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598010891	S-adenosylmethionine binding site [chemical binding]; other site
700598010892	Sulfatase; Region: Sulfatase; pfam00884
700598010893	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
700598010894	active site
700598010895	Domain of unknown function DUF21; Region: DUF21; pfam01595
700598010896	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
700598010897	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
700598010898	Transporter associated domain; Region: CorC_HlyC; smart01091
700598010899	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
700598010900	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
700598010901	Zn binding site [ion binding]; other site
700598010902	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598010903	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598010904	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598010905	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598010906	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598010907	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
700598010908	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598010909	Gram-negative bacterial tonB protein; Region: TonB; cl10048
700598010910	Dehydroquinase class II; Region: DHquinase_II; pfam01220
700598010911	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
700598010912	trimer interface [polypeptide binding]; other site
700598010913	active site
700598010914	dimer interface [polypeptide binding]; other site
700598010915	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
700598010916	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
700598010917	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
700598010918	catalytic site [active]
700598010919	subunit interface [polypeptide binding]; other site
700598010920	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
700598010921	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
700598010922	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
700598010923	alphaNTD - beta interaction site [polypeptide binding]; other site
700598010924	alphaNTD homodimer interface [polypeptide binding]; other site
700598010925	alphaNTD - beta' interaction site [polypeptide binding]; other site
700598010926	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
700598010927	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
700598010928	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
700598010929	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700598010930	RNA binding surface [nucleotide binding]; other site
700598010931	30S ribosomal protein S11; Validated; Region: PRK05309
700598010932	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
700598010933	30S ribosomal protein S13; Region: bact_S13; TIGR03631
700598010934	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
700598010935	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
700598010936	rRNA binding site [nucleotide binding]; other site
700598010937	predicted 30S ribosome binding site; other site
700598010938	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598010939	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598010940	putative substrate translocation pore; other site
700598010941	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598010942	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598010943	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
700598010944	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
700598010945	ABC-2 type transporter; Region: ABC2_membrane; cl17235
700598010946	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
700598010947	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
700598010948	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
700598010949	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
700598010950	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700598010951	Walker A/P-loop; other site
700598010952	ATP binding site [chemical binding]; other site
700598010953	Q-loop/lid; other site
700598010954	ABC transporter signature motif; other site
700598010955	Walker B; other site
700598010956	D-loop; other site
700598010957	H-loop/switch region; other site
700598010958	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700598010959	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700598010960	Walker A/P-loop; other site
700598010961	ATP binding site [chemical binding]; other site
700598010962	Q-loop/lid; other site
700598010963	ABC transporter signature motif; other site
700598010964	Walker B; other site
700598010965	D-loop; other site
700598010966	H-loop/switch region; other site
700598010967	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598010968	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598010969	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598010970	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
700598010971	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598010972	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598010973	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
700598010974	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598010975	hydrophobic ligand binding site; other site
700598010976	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
700598010977	active site
700598010978	metal binding site [ion binding]; metal-binding site
700598010979	homotetramer interface [polypeptide binding]; other site
700598010980	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
700598010981	Glyco_18 domain; Region: Glyco_18; smart00636
700598010982	active site
700598010983	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
700598010984	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598010985	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598010986	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598010987	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598010988	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598010989	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
700598010990	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598010991	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598010992	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598010993	PKD domain; Region: PKD; pfam00801
700598010994	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
700598010995	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
700598010996	PKD domain; Region: PKD; pfam00801
700598010997	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598010998	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598010999	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598011000	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
700598011001	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598011002	aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340
700598011003	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584
700598011004	substrate binding site [chemical binding]; other site
700598011005	ligand binding site [chemical binding]; other site
700598011006	Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578
700598011007	substrate binding site [chemical binding]; other site
700598011008	PspC domain; Region: PspC; cl00864
700598011009	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598011010	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011011	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
700598011012	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598011013	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
700598011014	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598011015	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598011016	NAD(P) binding site [chemical binding]; other site
700598011017	active site
700598011018	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598011019	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598011020	catalytic residues [active]
700598011021	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
700598011022	Acylphosphatase; Region: Acylphosphatase; pfam00708
700598011023	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
700598011024	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
700598011025	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
700598011026	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
700598011027	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
700598011028	histidinol dehydrogenase; Region: hisD; TIGR00069
700598011029	NAD binding site [chemical binding]; other site
700598011030	dimerization interface [polypeptide binding]; other site
700598011031	product binding site; other site
700598011032	substrate binding site [chemical binding]; other site
700598011033	zinc binding site [ion binding]; other site
700598011034	catalytic residues [active]
700598011035	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
700598011036	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598011037	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598011038	homodimer interface [polypeptide binding]; other site
700598011039	catalytic residue [active]
700598011040	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
700598011041	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
700598011042	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
700598011043	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
700598011044	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598011045	active site
700598011046	motif I; other site
700598011047	motif II; other site
700598011048	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
700598011049	putative active site pocket [active]
700598011050	4-fold oligomerization interface [polypeptide binding]; other site
700598011051	metal binding residues [ion binding]; metal-binding site
700598011052	3-fold/trimer interface [polypeptide binding]; other site
700598011053	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
700598011054	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
700598011055	Domain of unknown function DUF77; Region: DUF77; pfam01910
700598011056	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
700598011057	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
700598011058	Tetramer interface [polypeptide binding]; other site
700598011059	active site
700598011060	FMN-binding site [chemical binding]; other site
700598011061	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
700598011062	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
700598011063	hinge; other site
700598011064	active site
700598011065	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
700598011066	active site
700598011067	dimer interface [polypeptide binding]; other site
700598011068	metal binding site [ion binding]; metal-binding site
700598011069	Transposase IS200 like; Region: Y1_Tnp; pfam01797
700598011070	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
700598011071	Chorismate mutase type II; Region: CM_2; smart00830
700598011072	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
700598011073	DEAD-like helicases superfamily; Region: DEXDc; smart00487
700598011074	ATP binding site [chemical binding]; other site
700598011075	Mg++ binding site [ion binding]; other site
700598011076	motif III; other site
700598011077	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598011078	nucleotide binding region [chemical binding]; other site
700598011079	ATP-binding site [chemical binding]; other site
700598011080	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
700598011081	RNA binding site [nucleotide binding]; other site
700598011082	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
700598011083	prephenate dehydrogenase; Validated; Region: PRK08507
700598011084	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
700598011085	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598011086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598011087	homodimer interface [polypeptide binding]; other site
700598011088	catalytic residue [active]
700598011089	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
700598011090	Prephenate dehydratase; Region: PDT; pfam00800
700598011091	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
700598011092	putative L-Phe binding site [chemical binding]; other site
700598011093	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011094	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
700598011095	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
700598011096	putative active site [active]
700598011097	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
700598011098	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598011099	C-terminal peptidase (prc); Region: prc; TIGR00225
700598011100	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
700598011101	protein binding site [polypeptide binding]; other site
700598011102	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
700598011103	Catalytic dyad [active]
700598011104	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598011105	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598011106	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598011107	DNA binding residues [nucleotide binding]
700598011108	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
700598011109	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
700598011110	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
700598011111	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
700598011112	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
700598011113	RNA binding site [nucleotide binding]; other site
700598011114	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598011115	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
700598011116	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
700598011117	dimer interface [polypeptide binding]; other site
700598011118	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598011119	catalytic residue [active]
700598011120	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
700598011121	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
700598011122	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
700598011123	intersubunit interface [polypeptide binding]; other site
700598011124	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
700598011125	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
700598011126	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
700598011127	active site
700598011128	intersubunit interface [polypeptide binding]; other site
700598011129	zinc binding site [ion binding]; other site
700598011130	Na+ binding site [ion binding]; other site
700598011131	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
700598011132	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
700598011133	putative active site; other site
700598011134	catalytic residue [active]
700598011135	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
700598011136	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
700598011137	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
700598011138	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
700598011139	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
700598011140	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
700598011141	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
700598011142	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
700598011143	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598011144	catalytic residue [active]
700598011145	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
700598011146	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
700598011147	Flavoprotein; Region: Flavoprotein; pfam02441
700598011148	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
700598011149	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
700598011150	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
700598011151	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
700598011152	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
700598011153	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
700598011154	Histidine kinase; Region: HisKA_3; pfam07730
700598011155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598011156	ATP binding site [chemical binding]; other site
700598011157	Mg2+ binding site [ion binding]; other site
700598011158	G-X-G motif; other site
700598011159	Protein of unknown function (DUF423); Region: DUF423; pfam04241
700598011160	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
700598011161	shikimate kinase; Provisional; Region: PRK13947
700598011162	ADP binding site [chemical binding]; other site
700598011163	magnesium binding site [ion binding]; other site
700598011164	putative shikimate binding site; other site
700598011165	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700598011166	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700598011167	active site
700598011168	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
700598011169	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598011170	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598011171	DNA binding residues [nucleotide binding]
700598011172	Domain of unknown function (DUF4302); Region: DUF4302; pfam14135
700598011173	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598011174	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598011175	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598011176	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598011177	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598011178	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598011179	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598011180	binding surface
700598011181	TPR motif; other site
700598011182	TPR repeat; Region: TPR_11; pfam13414
700598011183	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
700598011184	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598011185	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598011186	ligand binding site [chemical binding]; other site
700598011187	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598011188	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
700598011189	Right handed beta helix region; Region: Beta_helix; pfam13229
700598011190	Right handed beta helix region; Region: Beta_helix; pfam13229
700598011191	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598011192	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
700598011193	active site
700598011194	dimer interface [polypeptide binding]; other site
700598011195	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700598011196	kynureninase; Region: kynureninase; TIGR01814
700598011197	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598011198	catalytic residue [active]
700598011199	short chain dehydrogenase; Provisional; Region: PRK08339
700598011200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598011201	NAD(P) binding site [chemical binding]; other site
700598011202	active site
700598011203	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
700598011204	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
700598011205	active site
700598011206	catalytic site [active]
700598011207	metal binding site [ion binding]; metal-binding site
700598011208	antiporter inner membrane protein; Provisional; Region: PRK11670
700598011209	Domain of unknown function DUF59; Region: DUF59; pfam01883
700598011210	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
700598011211	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598011212	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
700598011213	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
700598011214	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
700598011215	Uncharacterized conserved protein [Function unknown]; Region: COG1739
700598011216	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
700598011217	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
700598011218	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
700598011219	catalytic motif [active]
700598011220	Zn binding site [ion binding]; other site
700598011221	RibD C-terminal domain; Region: RibD_C; pfam01872
700598011222	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
700598011223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598011224	S-adenosylmethionine binding site [chemical binding]; other site
700598011225	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
700598011226	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
700598011227	Uncharacterized protein family (UPF0370); Region: UPF0370; cl10119
700598011228	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
700598011229	SPFH domain / Band 7 family; Region: Band_7; pfam01145
700598011230	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
700598011231	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700598011232	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
700598011233	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598011234	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598011235	ligand binding site [chemical binding]; other site
700598011236	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011237	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
700598011238	peptidase T; Region: peptidase-T; TIGR01882
700598011239	metal binding site [ion binding]; metal-binding site
700598011240	dimer interface [polypeptide binding]; other site
700598011241	CAAX protease self-immunity; Region: Abi; pfam02517
700598011242	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
700598011243	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
700598011244	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
700598011245	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
700598011246	putative active site [active]
700598011247	substrate binding site [chemical binding]; other site
700598011248	putative cosubstrate binding site; other site
700598011249	catalytic site [active]
700598011250	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
700598011251	substrate binding site [chemical binding]; other site
700598011252	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
700598011253	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
700598011254	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
700598011255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598011256	S-adenosylmethionine binding site [chemical binding]; other site
700598011257	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
700598011258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
700598011259	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
700598011260	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
700598011261	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
700598011262	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
700598011263	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
700598011264	ligand binding site [chemical binding]; other site
700598011265	homodimer interface [polypeptide binding]; other site
700598011266	NAD(P) binding site [chemical binding]; other site
700598011267	trimer interface B [polypeptide binding]; other site
700598011268	trimer interface A [polypeptide binding]; other site
700598011269	Methyltransferase domain; Region: Methyltransf_24; pfam13578
700598011270	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
700598011271	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
700598011272	folate binding site [chemical binding]; other site
700598011273	NADP+ binding site [chemical binding]; other site
700598011274	thymidylate synthase; Reviewed; Region: thyA; PRK01827
700598011275	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
700598011276	dimerization interface [polypeptide binding]; other site
700598011277	active site
700598011278	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
700598011279	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598011280	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598011281	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598011282	DNA binding residues [nucleotide binding]
700598011283	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598011284	FecR protein; Region: FecR; pfam04773
700598011285	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598011286	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598011287	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
700598011288	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
700598011289	Amb_all domain; Region: Amb_all; smart00656
700598011290	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
700598011291	Ca binding site [ion binding]; other site
700598011292	Ca binding site (active) [ion binding]; other site
700598011293	ligand binding site [chemical binding]; other site
700598011294	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011295	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
700598011296	Ca binding site [ion binding]; other site
700598011297	Ca binding site (active) [ion binding]; other site
700598011298	ligand binding site [chemical binding]; other site
700598011299	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011300	Response regulator receiver domain; Region: Response_reg; pfam00072
700598011301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598011302	active site
700598011303	phosphorylation site [posttranslational modification]
700598011304	intermolecular recognition site; other site
700598011305	dimerization interface [polypeptide binding]; other site
700598011306	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
700598011307	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
700598011308	active site
700598011309	DNA binding site [nucleotide binding]
700598011310	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
700598011311	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
700598011312	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
700598011313	active site
700598011314	PHP Thumb interface [polypeptide binding]; other site
700598011315	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
700598011316	generic binding surface II; other site
700598011317	generic binding surface I; other site
700598011318	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897
700598011319	putative hydrophobic ligand binding site [chemical binding]; other site
700598011320	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
700598011321	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598011322	active site
700598011323	metal binding site [ion binding]; metal-binding site
700598011324	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
700598011325	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577
700598011326	putative active site [active]
700598011327	catalytic site [active]
700598011328	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598011329	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598011330	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598011331	NADH(P)-binding; Region: NAD_binding_10; pfam13460
700598011332	NAD(P) binding site [chemical binding]; other site
700598011333	active site
700598011334	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700598011335	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700598011336	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598011337	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598011338	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598011339	catalytic residues [active]
700598011340	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
700598011341	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
700598011342	active site
700598011343	Beta/Gamma crystallin; Region: Crystall; cl02528
700598011344	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011345	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
700598011346	Short C-terminal domain; Region: SHOCT; pfam09851
700598011347	Predicted membrane protein [Function unknown]; Region: COG2259
700598011348	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598011349	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598011350	ligand binding site [chemical binding]; other site
700598011351	flexible hinge region; other site
700598011352	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
700598011353	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
700598011354	cyclase homology domain; Region: CHD; cd07302
700598011355	dimer interface [polypeptide binding]; other site
700598011356	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
700598011357	nucleotidyl binding site; other site
700598011358	metal binding site [ion binding]; metal-binding site
700598011359	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598011360	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011361	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574
700598011362	active site
700598011363	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
700598011364	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011365	Sel1-like repeats; Region: SEL1; smart00671
700598011366	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
700598011367	Sel1-like repeats; Region: SEL1; smart00671
700598011368	Sel1-like repeats; Region: SEL1; smart00671
700598011369	Sel1-like repeats; Region: SEL1; smart00671
700598011370	Sel1-like repeats; Region: SEL1; smart00671
700598011371	Sel1-like repeats; Region: SEL1; smart00671
700598011372	Sel1-like repeats; Region: SEL1; smart00671
700598011373	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
700598011374	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
700598011375	Protein of unknown function (DUF998); Region: DUF998; pfam06197
700598011376	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
700598011377	FMN binding site [chemical binding]; other site
700598011378	FMN binding site [chemical binding]; other site
700598011379	dimer interface [polypeptide binding]; other site
700598011380	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
700598011381	DoxX-like family; Region: DoxX_2; pfam13564
700598011382	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011383	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
700598011384	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
700598011385	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598011386	ATP binding site [chemical binding]; other site
700598011387	putative Mg++ binding site [ion binding]; other site
700598011388	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598011389	nucleotide binding region [chemical binding]; other site
700598011390	ATP-binding site [chemical binding]; other site
700598011391	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
700598011392	Proline dehydrogenase; Region: Pro_dh; cl03282
700598011393	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
700598011394	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
700598011395	active site
700598011396	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
700598011397	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700598011398	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
700598011399	putative acyl-acceptor binding pocket; other site
700598011400	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
700598011401	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
700598011402	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598011403	motif II; other site
700598011404	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
700598011405	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
700598011406	RNA binding site [nucleotide binding]; other site
700598011407	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
700598011408	RNA binding site [nucleotide binding]; other site
700598011409	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
700598011410	RNA binding site [nucleotide binding]; other site
700598011411	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
700598011412	RNA binding site [nucleotide binding]; other site
700598011413	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
700598011414	RNA binding site [nucleotide binding]; other site
700598011415	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
700598011416	RNA binding site [nucleotide binding]; other site
700598011417	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
700598011418	flavoprotein, HI0933 family; Region: TIGR00275
700598011419	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598011420	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
700598011421	active site
700598011422	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
700598011423	SecY translocase; Region: SecY; pfam00344
700598011424	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
700598011425	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
700598011426	23S rRNA binding site [nucleotide binding]; other site
700598011427	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
700598011428	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
700598011429	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
700598011430	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
700598011431	5S rRNA interface [nucleotide binding]; other site
700598011432	23S rRNA interface [nucleotide binding]; other site
700598011433	L5 interface [polypeptide binding]; other site
700598011434	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
700598011435	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
700598011436	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
700598011437	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
700598011438	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
700598011439	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
700598011440	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
700598011441	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
700598011442	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
700598011443	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
700598011444	RNA binding site [nucleotide binding]; other site
700598011445	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
700598011446	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
700598011447	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
700598011448	23S rRNA interface [nucleotide binding]; other site
700598011449	putative translocon interaction site; other site
700598011450	signal recognition particle (SRP54) interaction site; other site
700598011451	L23 interface [polypeptide binding]; other site
700598011452	trigger factor interaction site; other site
700598011453	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
700598011454	23S rRNA interface [nucleotide binding]; other site
700598011455	5S rRNA interface [nucleotide binding]; other site
700598011456	putative antibiotic binding site [chemical binding]; other site
700598011457	L25 interface [polypeptide binding]; other site
700598011458	L27 interface [polypeptide binding]; other site
700598011459	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
700598011460	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
700598011461	G-X-X-G motif; other site
700598011462	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
700598011463	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
700598011464	putative translocon binding site; other site
700598011465	protein-rRNA interface [nucleotide binding]; other site
700598011466	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
700598011467	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
700598011468	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
700598011469	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
700598011470	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
700598011471	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
700598011472	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
700598011473	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
700598011474	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
700598011475	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598011476	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598011477	elongation factor G; Reviewed; Region: PRK12739
700598011478	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
700598011479	G1 box; other site
700598011480	putative GEF interaction site [polypeptide binding]; other site
700598011481	GTP/Mg2+ binding site [chemical binding]; other site
700598011482	Switch I region; other site
700598011483	G2 box; other site
700598011484	G3 box; other site
700598011485	Switch II region; other site
700598011486	G4 box; other site
700598011487	G5 box; other site
700598011488	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
700598011489	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
700598011490	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
700598011491	Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388
700598011492	Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388
700598011493	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
700598011494	active site
700598011495	catalytic triad [active]
700598011496	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011497	30S ribosomal protein S7; Validated; Region: PRK05302
700598011498	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
700598011499	S17 interaction site [polypeptide binding]; other site
700598011500	S8 interaction site; other site
700598011501	16S rRNA interaction site [nucleotide binding]; other site
700598011502	streptomycin interaction site [chemical binding]; other site
700598011503	23S rRNA interaction site [nucleotide binding]; other site
700598011504	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
700598011505	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
700598011506	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
700598011507	homodimer interface [polypeptide binding]; other site
700598011508	substrate-cofactor binding pocket; other site
700598011509	catalytic residue [active]
700598011510	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
700598011511	active site
700598011512	dimerization interface [polypeptide binding]; other site
700598011513	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
700598011514	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598011515	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598011516	DNA binding residues [nucleotide binding]
700598011517	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
700598011518	active site
700598011519	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
700598011520	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
700598011521	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
700598011522	shikimate binding site; other site
700598011523	NAD(P) binding site [chemical binding]; other site
700598011524	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
700598011525	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598011526	TPR motif; other site
700598011527	binding surface
700598011528	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598011529	binding surface
700598011530	TPR motif; other site
700598011531	TPR repeat; Region: TPR_11; pfam13414
700598011532	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598011533	binding surface
700598011534	TPR motif; other site
700598011535	TPR repeat; Region: TPR_11; pfam13414
700598011536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598011537	binding surface
700598011538	TPR motif; other site
700598011539	TPR repeat; Region: TPR_11; pfam13414
700598011540	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598011541	binding surface
700598011542	TPR motif; other site
700598011543	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
700598011544	membrane protein insertase; Provisional; Region: PRK01318
700598011545	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
700598011546	CTP synthetase; Validated; Region: pyrG; PRK05380
700598011547	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
700598011548	Catalytic site [active]
700598011549	active site
700598011550	UTP binding site [chemical binding]; other site
700598011551	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
700598011552	active site
700598011553	putative oxyanion hole; other site
700598011554	catalytic triad [active]
700598011555	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
700598011556	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
700598011557	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
700598011558	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
700598011559	NADP binding site [chemical binding]; other site
700598011560	homopentamer interface [polypeptide binding]; other site
700598011561	substrate binding site [chemical binding]; other site
700598011562	active site
700598011563	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
700598011564	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
700598011565	dimerization interface [polypeptide binding]; other site
700598011566	ATP binding site [chemical binding]; other site
700598011567	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
700598011568	dimerization interface [polypeptide binding]; other site
700598011569	ATP binding site [chemical binding]; other site
700598011570	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598011571	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598011572	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
700598011573	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
700598011574	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598011575	putative ADP-binding pocket [chemical binding]; other site
700598011576	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
700598011577	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
700598011578	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
700598011579	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
700598011580	nudix motif; other site
700598011581	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011582	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011583	cytidylate kinase; Provisional; Region: cmk; PRK00023
700598011584	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
700598011585	CMP-binding site; other site
700598011586	The sites determining sugar specificity; other site
700598011587	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
700598011588	Clp amino terminal domain; Region: Clp_N; pfam02861
700598011589	Clp amino terminal domain; Region: Clp_N; pfam02861
700598011590	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598011591	Walker A motif; other site
700598011592	ATP binding site [chemical binding]; other site
700598011593	Walker B motif; other site
700598011594	arginine finger; other site
700598011595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598011596	Walker A motif; other site
700598011597	ATP binding site [chemical binding]; other site
700598011598	Walker B motif; other site
700598011599	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
700598011600	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700598011601	anti sigma factor interaction site; other site
700598011602	regulatory phosphorylation site [posttranslational modification]; other site
700598011603	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
700598011604	substrate binding site; other site
700598011605	dimer interface; other site
700598011606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598011607	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
700598011608	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
700598011609	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
700598011610	Zn binding site [ion binding]; other site
700598011611	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
700598011612	Zn binding site [ion binding]; other site
700598011613	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
700598011614	Bacterial sugar transferase; Region: Bac_transf; pfam02397
700598011615	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598011616	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598011617	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
700598011618	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
700598011619	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598011620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598011621	active site
700598011622	phosphorylation site [posttranslational modification]
700598011623	intermolecular recognition site; other site
700598011624	dimerization interface [polypeptide binding]; other site
700598011625	LytTr DNA-binding domain; Region: LytTR; smart00850
700598011626	Histidine kinase; Region: His_kinase; pfam06580
700598011627	Galactose oxidase, central domain; Region: Kelch_3; cl02701
700598011628	Galactose oxidase, central domain; Region: Kelch_3; cl02701
700598011629	Kelch motif; Region: Kelch_6; pfam13964
700598011630	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
700598011631	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
700598011632	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
700598011633	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
700598011634	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700598011635	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011636	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
700598011637	trimer interface [polypeptide binding]; other site
700598011638	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
700598011639	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598011640	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011641	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598011642	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011643	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598011644	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011645	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
700598011646	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598011647	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700598011648	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598011649	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
700598011650	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598011651	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598011652	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598011653	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598011654	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598011655	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598011656	FecR protein; Region: FecR; pfam04773
700598011657	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598011658	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598011659	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598011660	DNA binding residues [nucleotide binding]
700598011661	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
700598011662	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598011663	binding surface
700598011664	TPR motif; other site
700598011665	Histidine kinase; Region: His_kinase; pfam06580
700598011666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
700598011667	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598011668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598011669	active site
700598011670	phosphorylation site [posttranslational modification]
700598011671	intermolecular recognition site; other site
700598011672	dimerization interface [polypeptide binding]; other site
700598011673	LytTr DNA-binding domain; Region: LytTR; pfam04397
700598011674	RteC protein; Region: RteC; pfam09357
700598011675	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598011676	TIR domain; Region: TIR_2; pfam13676
700598011677	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
700598011678	von Willebrand factor type A domain; Region: VWA_2; pfam13519
700598011679	metal ion-dependent adhesion site (MIDAS); other site
700598011680	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
700598011681	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
700598011682	AAA domain; Region: AAA_21; pfam13304
700598011683	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
700598011684	Divergent AAA domain; Region: AAA_4; pfam04326
700598011685	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
700598011686	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
700598011687	Outer membrane efflux protein; Region: OEP; pfam02321
700598011688	Outer membrane efflux protein; Region: OEP; pfam02321
700598011689	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598011690	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
700598011691	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598011692	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
700598011693	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
700598011694	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
700598011695	active site
700598011696	substrate binding site [chemical binding]; other site
700598011697	Mg2+ binding site [ion binding]; other site
700598011698	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598011699	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598011700	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700598011701	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598011702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598011703	active site
700598011704	phosphorylation site [posttranslational modification]
700598011705	intermolecular recognition site; other site
700598011706	dimerization interface [polypeptide binding]; other site
700598011707	SnoaL-like domain; Region: SnoaL_2; pfam12680
700598011708	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
700598011709	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
700598011710	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
700598011711	active site
700598011712	catalytic site [active]
700598011713	substrate binding site [chemical binding]; other site
700598011714	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
700598011715	phosphopeptide binding site; other site
700598011716	Transthyretin-like family; Region: DUF290; pfam01060
700598011717	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
700598011718	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
700598011719	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700598011720	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700598011721	active site
700598011722	ATP binding site [chemical binding]; other site
700598011723	substrate binding site [chemical binding]; other site
700598011724	activation loop (A-loop); other site
700598011725	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
700598011726	active site
700598011727	PQQ-like domain; Region: PQQ_2; pfam13360
700598011728	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011729	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598011730	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011731	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
700598011732	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598011733	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598011734	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011735	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
700598011736	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
700598011737	tetramer interface [polypeptide binding]; other site
700598011738	active site
700598011739	Mg2+/Mn2+ binding site [ion binding]; other site
700598011740	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
700598011741	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
700598011742	RibD C-terminal domain; Region: RibD_C; cl17279
700598011743	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598011744	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
700598011745	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
700598011746	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
700598011747	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700598011748	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700598011749	DEAD-like helicases superfamily; Region: DEXDc; smart00487
700598011750	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598011751	ATP binding site [chemical binding]; other site
700598011752	putative Mg++ binding site [ion binding]; other site
700598011753	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598011754	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
700598011755	nucleotide binding region [chemical binding]; other site
700598011756	ATP-binding site [chemical binding]; other site
700598011757	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
700598011758	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598011759	ATP binding site [chemical binding]; other site
700598011760	putative Mg++ binding site [ion binding]; other site
700598011761	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598011762	ATP-binding site [chemical binding]; other site
700598011763	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
700598011764	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
700598011765	Part of AAA domain; Region: AAA_19; pfam13245
700598011766	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
700598011767	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
700598011768	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
700598011769	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
700598011770	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
700598011771	CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592
700598011772	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
700598011773	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
700598011774	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
700598011775	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598011776	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
700598011777	ligand binding site [chemical binding]; other site
700598011778	flexible hinge region; other site
700598011779	short chain dehydrogenase; Validated; Region: PRK06182
700598011780	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598011781	NADP binding site [chemical binding]; other site
700598011782	active site
700598011783	steroid binding site; other site
700598011784	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
700598011785	putative hydrophobic ligand binding site [chemical binding]; other site
700598011786	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700598011787	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598011788	Coenzyme A binding pocket [chemical binding]; other site
700598011789	carotene beta-ring hydroxylase; Region: PLN02738
700598011790	Response regulator receiver domain; Region: Response_reg; pfam00072
700598011791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598011792	active site
700598011793	phosphorylation site [posttranslational modification]
700598011794	intermolecular recognition site; other site
700598011795	dimerization interface [polypeptide binding]; other site
700598011796	Response regulator receiver domain; Region: Response_reg; pfam00072
700598011797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598011798	active site
700598011799	phosphorylation site [posttranslational modification]
700598011800	intermolecular recognition site; other site
700598011801	dimerization interface [polypeptide binding]; other site
700598011802	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
700598011803	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
700598011804	Low molecular weight phosphatase family; Region: LMWPc; cl00105
700598011805	active site
700598011806	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598011807	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598011808	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598011809	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598011810	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
700598011811	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598011812	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598011813	dimer interface [polypeptide binding]; other site
700598011814	phosphorylation site [posttranslational modification]
700598011815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598011816	ATP binding site [chemical binding]; other site
700598011817	Mg2+ binding site [ion binding]; other site
700598011818	G-X-G motif; other site
700598011819	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598011820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598011821	active site
700598011822	phosphorylation site [posttranslational modification]
700598011823	intermolecular recognition site; other site
700598011824	dimerization interface [polypeptide binding]; other site
700598011825	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598011826	DNA binding site [nucleotide binding]
700598011827	short chain dehydrogenase; Provisional; Region: PRK06180
700598011828	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598011829	NADP binding site [chemical binding]; other site
700598011830	active site
700598011831	steroid binding site; other site
700598011832	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598011833	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598011834	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598011835	TAP-like protein; Region: Abhydrolase_4; pfam08386
700598011836	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598011837	NADH(P)-binding; Region: NAD_binding_10; pfam13460
700598011838	NAD(P) binding site [chemical binding]; other site
700598011839	active site
700598011840	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598011841	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011842	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598011843	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598011844	ligand binding site [chemical binding]; other site
700598011845	flexible hinge region; other site
700598011846	short chain dehydrogenase; Provisional; Region: PRK06500
700598011847	classical (c) SDRs; Region: SDR_c; cd05233
700598011848	NAD(P) binding site [chemical binding]; other site
700598011849	active site
700598011850	short chain dehydrogenase; Provisional; Region: PRK06500
700598011851	classical (c) SDRs; Region: SDR_c; cd05233
700598011852	NAD(P) binding site [chemical binding]; other site
700598011853	active site
700598011854	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598011855	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598011856	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700598011857	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
700598011858	FMN binding site [chemical binding]; other site
700598011859	active site
700598011860	substrate binding site [chemical binding]; other site
700598011861	catalytic residue [active]
700598011862	DinB family; Region: DinB; cl17821
700598011863	DinB superfamily; Region: DinB_2; pfam12867
700598011864	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598011865	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011866	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011867	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
700598011868	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598011869	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598011870	ligand binding site [chemical binding]; other site
700598011871	flexible hinge region; other site
700598011872	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598011873	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
700598011874	catalytic tetrad [active]
700598011875	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
700598011876	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
700598011877	maltose O-acetyltransferase; Provisional; Region: PRK10092
700598011878	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
700598011879	active site
700598011880	substrate binding site [chemical binding]; other site
700598011881	trimer interface [polypeptide binding]; other site
700598011882	CoA binding site [chemical binding]; other site
700598011883	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598011884	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011885	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598011886	DNA-binding site [nucleotide binding]; DNA binding site
700598011887	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700598011888	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700598011889	Walker A/P-loop; other site
700598011890	ATP binding site [chemical binding]; other site
700598011891	Q-loop/lid; other site
700598011892	ABC transporter signature motif; other site
700598011893	Walker B; other site
700598011894	D-loop; other site
700598011895	H-loop/switch region; other site
700598011896	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
700598011897	Peptidase family M23; Region: Peptidase_M23; pfam01551
700598011898	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
700598011899	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700598011900	active site
700598011901	DNA binding site [nucleotide binding]
700598011902	Int/Topo IB signature motif; other site
700598011903	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700598011904	TIGR02646 family protein; Region: TIGR02646
700598011905	AAA domain; Region: AAA_21; pfam13304
700598011906	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
700598011907	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
700598011908	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
700598011909	ORF6N domain; Region: ORF6N; pfam10543
700598011910	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700598011911	active site
700598011912	DNA binding site [nucleotide binding]
700598011913	Int/Topo IB signature motif; other site
700598011914	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
700598011915	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
700598011916	active site
700598011917	catalytic residues [active]
700598011918	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
700598011919	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598011920	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
700598011921	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
700598011922	Ca binding site [ion binding]; other site
700598011923	ligand binding site I [chemical binding]; other site
700598011924	homodimer interface [polypeptide binding]; other site
700598011925	ligand binding site II [chemical binding]; other site
700598011926	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
700598011927	PKC phosphorylation site [posttranslational modification]; other site
700598011928	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598011929	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598011930	FtsX-like permease family; Region: FtsX; pfam02687
700598011931	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598011932	FtsX-like permease family; Region: FtsX; pfam02687
700598011933	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
700598011934	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
700598011935	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598011936	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598011937	short chain dehydrogenase; Provisional; Region: PRK12937
700598011938	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
700598011939	NADP binding site [chemical binding]; other site
700598011940	homodimer interface [polypeptide binding]; other site
700598011941	active site
700598011942	substrate binding site [chemical binding]; other site
700598011943	Predicted membrane protein [Function unknown]; Region: COG2510
700598011944	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
700598011945	active site
700598011946	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
700598011947	KTSC domain; Region: KTSC; pfam13619
700598011948	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
700598011949	active site
700598011950	DNA binding site [nucleotide binding]
700598011951	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
700598011952	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
700598011953	DNA binding site [nucleotide binding]
700598011954	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
700598011955	nucleotide binding site [chemical binding]; other site
700598011956	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
700598011957	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
700598011958	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
700598011959	dihydrodipicolinate synthase; Region: dapA; TIGR00674
700598011960	dimer interface [polypeptide binding]; other site
700598011961	active site
700598011962	catalytic residue [active]
700598011963	ribonuclease Z; Region: RNase_Z; TIGR02651
700598011964	Phosphotransferase enzyme family; Region: APH; pfam01636
700598011965	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
700598011966	active site
700598011967	ATP binding site [chemical binding]; other site
700598011968	Predicted kinase [General function prediction only]; Region: COG4857; cl17281
700598011969	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
700598011970	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
700598011971	putative ribose interaction site [chemical binding]; other site
700598011972	putative ADP binding site [chemical binding]; other site
700598011973	amino acid transporter; Region: 2A0306; TIGR00909
700598011974	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
700598011975	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
700598011976	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
700598011977	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
700598011978	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
700598011979	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
700598011980	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
700598011981	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
700598011982	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
700598011983	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
700598011984	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
700598011985	DNA binding site [nucleotide binding]
700598011986	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
700598011987	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
700598011988	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
700598011989	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
700598011990	RPB11 interaction site [polypeptide binding]; other site
700598011991	RPB12 interaction site [polypeptide binding]; other site
700598011992	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
700598011993	RPB12 interaction site [polypeptide binding]; other site
700598011994	RPB3 interaction site [polypeptide binding]; other site
700598011995	RPB1 interaction site [polypeptide binding]; other site
700598011996	RPB11 interaction site [polypeptide binding]; other site
700598011997	RPB10 interaction site [polypeptide binding]; other site
700598011998	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598011999	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598012000	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598012001	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012002	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598012003	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598012004	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598012005	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598012006	DNA binding site [nucleotide binding]
700598012007	domain linker motif; other site
700598012008	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598012009	dimerization interface [polypeptide binding]; other site
700598012010	ligand binding site [chemical binding]; other site
700598012011	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
700598012012	core dimer interface [polypeptide binding]; other site
700598012013	peripheral dimer interface [polypeptide binding]; other site
700598012014	L10 interface [polypeptide binding]; other site
700598012015	L11 interface [polypeptide binding]; other site
700598012016	putative EF-Tu interaction site [polypeptide binding]; other site
700598012017	putative EF-G interaction site [polypeptide binding]; other site
700598012018	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
700598012019	23S rRNA interface [nucleotide binding]; other site
700598012020	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
700598012021	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
700598012022	mRNA/rRNA interface [nucleotide binding]; other site
700598012023	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
700598012024	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
700598012025	23S rRNA interface [nucleotide binding]; other site
700598012026	L7/L12 interface [polypeptide binding]; other site
700598012027	putative thiostrepton binding site; other site
700598012028	L25 interface [polypeptide binding]; other site
700598012029	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
700598012030	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
700598012031	putative homodimer interface [polypeptide binding]; other site
700598012032	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
700598012033	heterodimer interface [polypeptide binding]; other site
700598012034	homodimer interface [polypeptide binding]; other site
700598012035	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
700598012036	elongation factor Tu; Reviewed; Region: PRK00049
700598012037	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
700598012038	G1 box; other site
700598012039	GEF interaction site [polypeptide binding]; other site
700598012040	GTP/Mg2+ binding site [chemical binding]; other site
700598012041	Switch I region; other site
700598012042	G2 box; other site
700598012043	G3 box; other site
700598012044	Switch II region; other site
700598012045	G4 box; other site
700598012046	G5 box; other site
700598012047	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
700598012048	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
700598012049	Antibiotic Binding Site [chemical binding]; other site
700598012050	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
700598012051	30S subunit binding site; other site
700598012052	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700598012053	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
700598012054	active site
700598012055	DNA binding site [nucleotide binding]
700598012056	Int/Topo IB signature motif; other site
700598012057	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
700598012058	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
700598012059	Lumazine binding domain; Region: Lum_binding; pfam00677
700598012060	Lumazine binding domain; Region: Lum_binding; pfam00677
700598012061	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598012062	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598012063	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598012064	active site
700598012065	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
700598012066	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
700598012067	Probable Catalytic site; other site
700598012068	metal-binding site
700598012069	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
700598012070	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598012071	FeS/SAM binding site; other site
700598012072	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
700598012073	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181
700598012074	active site
700598012075	CARDB; Region: CARDB; pfam07705
700598012076	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
700598012077	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
700598012078	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
700598012079	active site
700598012080	HIGH motif; other site
700598012081	dimer interface [polypeptide binding]; other site
700598012082	KMSKS motif; other site
700598012083	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700598012084	RNA binding surface [nucleotide binding]; other site
700598012085	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
700598012086	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700598012087	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598012088	catalytic residue [active]
700598012089	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
700598012090	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
700598012091	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598012092	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012093	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
700598012094	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598012095	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598012096	FecR protein; Region: FecR; pfam04773
700598012097	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598012098	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
700598012099	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598012100	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598012101	DNA binding residues [nucleotide binding]
700598012102	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598012103	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
700598012104	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
700598012105	Catalytic dyad [active]
700598012106	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
700598012107	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598012108	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598012109	G8 domain; Region: G8; pfam10162
700598012110	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
700598012111	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700598012112	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598012113	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700598012114	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598012115	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598012116	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598012117	active site
700598012118	Methylamine utilisation protein MauE; Region: MauE; pfam07291
700598012119	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700598012120	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598012121	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
700598012122	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598012123	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598012124	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598012125	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598012126	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012127	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598012128	FecR protein; Region: FecR; pfam04773
700598012129	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598012130	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598012131	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598012132	DNA binding residues [nucleotide binding]
700598012133	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
700598012134	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
700598012135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
700598012136	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598012137	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598012138	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598012139	Protein of unknown function (DUF3823); Region: DUF3823; pfam12866
700598012140	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598012141	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598012142	SusD family; Region: SusD; pfam07980
700598012143	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598012144	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012145	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598012146	potential frameshift: common BLAST hit: gi|255530419|ref|YP_003090791.1| response regulator receiver
700598012147	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598012148	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598012149	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598012150	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598012151	dimer interface [polypeptide binding]; other site
700598012152	phosphorylation site [posttranslational modification]
700598012153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598012154	ATP binding site [chemical binding]; other site
700598012155	Mg2+ binding site [ion binding]; other site
700598012156	G-X-G motif; other site
700598012157	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598012158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598012159	active site
700598012160	phosphorylation site [posttranslational modification]
700598012161	intermolecular recognition site; other site
700598012162	dimerization interface [polypeptide binding]; other site
700598012163	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598012164	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598012165	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
700598012166	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
700598012167	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700598012168	Uncharacterized conserved protein [Function unknown]; Region: COG3538
700598012169	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
700598012170	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
700598012171	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598012172	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598012173	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012174	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
700598012175	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
700598012176	amidase catalytic site [active]
700598012177	Zn binding residues [ion binding]; other site
700598012178	substrate binding site [chemical binding]; other site
700598012179	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012180	Stage II sporulation protein; Region: SpoIID; pfam08486
700598012181	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012182	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598012183	Stage II sporulation protein; Region: SpoIID; pfam08486
700598012184	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012185	Stage II sporulation protein; Region: SpoIID; pfam08486
700598012186	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012187	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
700598012188	catalytic site [active]
700598012189	BNR repeat-like domain; Region: BNR_2; pfam13088
700598012190	Asp-box motif; other site
700598012191	PAS fold; Region: PAS_4; pfam08448
700598012192	PAS domain S-box; Region: sensory_box; TIGR00229
700598012193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598012194	putative active site [active]
700598012195	heme pocket [chemical binding]; other site
700598012196	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598012197	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598012198	putative active site [active]
700598012199	heme pocket [chemical binding]; other site
700598012200	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598012201	Histidine kinase; Region: HisKA_3; pfam07730
700598012202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598012203	ATP binding site [chemical binding]; other site
700598012204	Mg2+ binding site [ion binding]; other site
700598012205	G-X-G motif; other site
700598012206	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700598012207	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700598012208	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598012209	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012210	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598012211	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598012212	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598012213	TIR domain; Region: TIR_2; pfam13676
700598012214	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
700598012215	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598012216	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598012217	DNA binding residues [nucleotide binding]
700598012218	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
700598012219	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
700598012220	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
700598012221	NADP binding site [chemical binding]; other site
700598012222	active site
700598012223	putative substrate binding site [chemical binding]; other site
700598012224	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
700598012225	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
700598012226	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
700598012227	NAD binding site [chemical binding]; other site
700598012228	substrate binding site [chemical binding]; other site
700598012229	homodimer interface [polypeptide binding]; other site
700598012230	active site
700598012231	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598012232	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
700598012233	NAD binding site [chemical binding]; other site
700598012234	putative substrate binding site 2 [chemical binding]; other site
700598012235	putative substrate binding site 1 [chemical binding]; other site
700598012236	active site
700598012237	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
700598012238	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
700598012239	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
700598012240	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
700598012241	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
700598012242	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
700598012243	inhibitor-cofactor binding pocket; inhibition site
700598012244	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598012245	catalytic residue [active]
700598012246	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
700598012247	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
700598012248	thymidine kinase; Provisional; Region: PRK04296
700598012249	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
700598012250	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
700598012251	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
700598012252	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
700598012253	NAD(P) binding site [chemical binding]; other site
700598012254	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
700598012255	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
700598012256	AMP nucleosidase; Provisional; Region: PRK07115
700598012257	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
700598012258	putative active site [active]
700598012259	Zn binding site [ion binding]; other site
700598012260	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
700598012261	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
700598012262	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
700598012263	TPP-binding site [chemical binding]; other site
700598012264	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
700598012265	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
700598012266	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700598012267	E3 interaction surface; other site
700598012268	lipoyl attachment site [posttranslational modification]; other site
700598012269	e3 binding domain; Region: E3_binding; pfam02817
700598012270	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
700598012271	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
700598012272	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
700598012273	active site
700598012274	catalytic residues [active]
700598012275	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012276	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
700598012277	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
700598012278	Ligand Binding Site [chemical binding]; other site
700598012279	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
700598012280	putative active site [active]
700598012281	Zn binding site [ion binding]; other site
700598012282	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
700598012283	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
700598012284	dimer interface [polypeptide binding]; other site
700598012285	ssDNA binding site [nucleotide binding]; other site
700598012286	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700598012287	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598012288	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598012289	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
700598012290	Ycf48-like protein; Provisional; Region: PRK13684
700598012291	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
700598012292	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012293	aspartate kinase III; Validated; Region: PRK09084
700598012294	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
700598012295	nucleotide binding site [chemical binding]; other site
700598012296	substrate binding site [chemical binding]; other site
700598012297	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
700598012298	dimer interface [polypeptide binding]; other site
700598012299	allosteric regulatory binding pocket; other site
700598012300	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
700598012301	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598012302	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598012303	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
700598012304	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
700598012305	TraB family; Region: TraB; pfam01963
700598012306	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
700598012307	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
700598012308	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700598012309	Walker A/P-loop; other site
700598012310	ATP binding site [chemical binding]; other site
700598012311	Q-loop/lid; other site
700598012312	ABC transporter signature motif; other site
700598012313	Walker B; other site
700598012314	D-loop; other site
700598012315	H-loop/switch region; other site
700598012316	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
700598012317	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700598012318	Walker A/P-loop; other site
700598012319	ATP binding site [chemical binding]; other site
700598012320	Q-loop/lid; other site
700598012321	ABC transporter signature motif; other site
700598012322	Walker B; other site
700598012323	D-loop; other site
700598012324	H-loop/switch region; other site
700598012325	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
700598012326	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
700598012327	MG2 domain; Region: A2M_N; pfam01835
700598012328	Alpha-2-macroglobulin family; Region: A2M; pfam00207
700598012329	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
700598012330	surface patch; other site
700598012331	thioester region; other site
700598012332	specificity defining residues; other site
700598012333	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
700598012334	Transglycosylase; Region: Transgly; pfam00912
700598012335	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
700598012336	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
700598012337	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
700598012338	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
700598012339	GMP synthase; Reviewed; Region: guaA; PRK00074
700598012340	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
700598012341	AMP/PPi binding site [chemical binding]; other site
700598012342	candidate oxyanion hole; other site
700598012343	catalytic triad [active]
700598012344	potential glutamine specificity residues [chemical binding]; other site
700598012345	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
700598012346	ATP Binding subdomain [chemical binding]; other site
700598012347	Ligand Binding sites [chemical binding]; other site
700598012348	Dimerization subdomain; other site
700598012349	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
700598012350	ligand binding site [chemical binding]; other site
700598012351	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
700598012352	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
700598012353	ATP-dependent DNA ligase; Validated; Region: PRK09247
700598012354	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
700598012355	active site
700598012356	DNA binding site [nucleotide binding]
700598012357	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
700598012358	DNA binding site [nucleotide binding]
700598012359	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
700598012360	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012361	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
700598012362	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598012363	ATP binding site [chemical binding]; other site
700598012364	putative Mg++ binding site [ion binding]; other site
700598012365	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598012366	nucleotide binding region [chemical binding]; other site
700598012367	ATP-binding site [chemical binding]; other site
700598012368	DEAD/H associated; Region: DEAD_assoc; pfam08494
700598012369	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598012370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598012371	active site
700598012372	phosphorylation site [posttranslational modification]
700598012373	intermolecular recognition site; other site
700598012374	dimerization interface [polypeptide binding]; other site
700598012375	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598012376	DNA binding residues [nucleotide binding]
700598012377	dimerization interface [polypeptide binding]; other site
700598012378	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
700598012379	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
700598012380	homodimer interface [polypeptide binding]; other site
700598012381	substrate-cofactor binding pocket; other site
700598012382	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598012383	catalytic residue [active]
700598012384	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
700598012385	DNA photolyase; Region: DNA_photolyase; pfam00875
700598012386	Phosphotransferase enzyme family; Region: APH; pfam01636
700598012387	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700598012388	active site
700598012389	ATP binding site [chemical binding]; other site
700598012390	substrate binding site [chemical binding]; other site
700598012391	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
700598012392	futalosine nucleosidase; Region: fut_nucase; TIGR03664
700598012393	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
700598012394	active site
700598012395	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
700598012396	active site
700598012397	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
700598012398	homodecamer interface [polypeptide binding]; other site
700598012399	GTP cyclohydrolase I; Provisional; Region: PLN03044
700598012400	active site
700598012401	putative catalytic site residues [active]
700598012402	zinc binding site [ion binding]; other site
700598012403	GTP-CH-I/GFRP interaction surface; other site
700598012404	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
700598012405	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
700598012406	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
700598012407	protein binding site [polypeptide binding]; other site
700598012408	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
700598012409	Catalytic dyad [active]
700598012410	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598012411	Coenzyme A binding pocket [chemical binding]; other site
700598012412	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
700598012413	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
700598012414	active site
700598012415	putative substrate binding pocket [chemical binding]; other site
700598012416	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598012417	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
700598012418	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
700598012419	dimer interface [polypeptide binding]; other site
700598012420	active site
700598012421	CoA binding pocket [chemical binding]; other site
700598012422	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
700598012423	RuvA N terminal domain; Region: RuvA_N; pfam01330
700598012424	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
700598012425	cell surface protein SprA; Region: surface_SprA; TIGR04189
700598012426	Motility related/secretion protein; Region: SprA_N; pfam14349
700598012427	Motility related/secretion protein; Region: SprA_N; pfam14349
700598012428	Motility related/secretion protein; Region: SprA_N; pfam14349
700598012429	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
700598012430	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
700598012431	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
700598012432	putative NAD(P) binding site [chemical binding]; other site
700598012433	homodimer interface [polypeptide binding]; other site
700598012434	homotetramer interface [polypeptide binding]; other site
700598012435	active site
700598012436	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598012437	PKD domain; Region: PKD; pfam00801
700598012438	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598012439	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
700598012440	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598012441	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700598012442	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
700598012443	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
700598012444	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
700598012445	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
700598012446	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
700598012447	active site
700598012448	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598012449	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700598012450	non-specific DNA binding site [nucleotide binding]; other site
700598012451	salt bridge; other site
700598012452	sequence-specific DNA binding site [nucleotide binding]; other site
700598012453	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
700598012454	Catalytic site [active]
700598012455	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
700598012456	putative ligand binding site [chemical binding]; other site
700598012457	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
700598012458	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
700598012459	putative active site [active]
700598012460	Zn binding site [ion binding]; other site
700598012461	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598012462	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
700598012463	putative active site [active]
700598012464	putative metal binding site [ion binding]; other site
700598012465	Haem-binding domain; Region: Haem_bd; pfam14376
700598012466	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598012467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598012468	active site
700598012469	phosphorylation site [posttranslational modification]
700598012470	intermolecular recognition site; other site
700598012471	dimerization interface [polypeptide binding]; other site
700598012472	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598012473	DNA binding residues [nucleotide binding]
700598012474	dimerization interface [polypeptide binding]; other site
700598012475	Histidine kinase; Region: HisKA_3; pfam07730
700598012476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598012477	ATP binding site [chemical binding]; other site
700598012478	Mg2+ binding site [ion binding]; other site
700598012479	G-X-G motif; other site
700598012480	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598012481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598012482	active site
700598012483	phosphorylation site [posttranslational modification]
700598012484	intermolecular recognition site; other site
700598012485	dimerization interface [polypeptide binding]; other site
700598012486	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598012487	DNA binding residues [nucleotide binding]
700598012488	dimerization interface [polypeptide binding]; other site
700598012489	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
700598012490	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
700598012491	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
700598012492	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
700598012493	Flavoprotein; Region: Flavoprotein; pfam02441
700598012494	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
700598012495	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
700598012496	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
700598012497	ligand binding site [chemical binding]; other site
700598012498	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
700598012499	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
700598012500	substrate binding pocket [chemical binding]; other site
700598012501	chain length determination region; other site
700598012502	substrate-Mg2+ binding site; other site
700598012503	catalytic residues [active]
700598012504	aspartate-rich region 1; other site
700598012505	active site lid residues [active]
700598012506	aspartate-rich region 2; other site
700598012507	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
700598012508	DHH family; Region: DHH; pfam01368
700598012509	DHHA1 domain; Region: DHHA1; pfam02272
700598012510	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598012511	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598012512	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598012513	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598012514	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700598012515	E3 interaction surface; other site
700598012516	lipoyl attachment site [posttranslational modification]; other site
700598012517	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598012518	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598012519	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
700598012520	heat shock protein 90; Provisional; Region: PRK05218
700598012521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598012522	ATP binding site [chemical binding]; other site
700598012523	Mg2+ binding site [ion binding]; other site
700598012524	G-X-G motif; other site
700598012525	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
700598012526	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012527	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
700598012528	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
700598012529	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
700598012530	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
700598012531	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
700598012532	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
700598012533	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
700598012534	Ligand binding site; other site
700598012535	Putative Catalytic site; other site
700598012536	DXD motif; other site
700598012537	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
700598012538	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598012539	motif II; other site
700598012540	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598012541	Ligand Binding Site [chemical binding]; other site
700598012542	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
700598012543	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
700598012544	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598012545	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598012546	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700598012547	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
700598012548	ApbE family; Region: ApbE; pfam02424
700598012549	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
700598012550	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
700598012551	dimerization interface 3.5A [polypeptide binding]; other site
700598012552	active site
700598012553	CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; cl11685
700598012554	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
700598012555	Peptidase family M1; Region: Peptidase_M1; pfam01433
700598012556	Zn binding site [ion binding]; other site
700598012557	HEAT repeats; Region: HEAT_2; pfam13646
700598012558	HEAT repeats; Region: HEAT_2; pfam13646
700598012559	Repair protein; Region: Repair_PSII; pfam04536
700598012560	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
700598012561	Repair protein; Region: Repair_PSII; pfam04536
700598012562	Repair protein; Region: Repair_PSII; pfam04536
700598012563	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
700598012564	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
700598012565	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
700598012566	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
700598012567	Phosphoglycerate kinase; Region: PGK; pfam00162
700598012568	substrate binding site [chemical binding]; other site
700598012569	hinge regions; other site
700598012570	ADP binding site [chemical binding]; other site
700598012571	catalytic site [active]
700598012572	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
700598012573	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
700598012574	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
700598012575	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
700598012576	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
700598012577	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
700598012578	XdhC Rossmann domain; Region: XdhC_C; pfam13478
700598012579	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
700598012580	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
700598012581	XdhC Rossmann domain; Region: XdhC_C; pfam13478
700598012582	YHS domain; Region: YHS; pfam04945
700598012583	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
700598012584	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
700598012585	metal ion-dependent adhesion site (MIDAS); other site
700598012586	MoxR-like ATPases [General function prediction only]; Region: COG0714
700598012587	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598012588	Walker A motif; other site
700598012589	ATP binding site [chemical binding]; other site
700598012590	Walker B motif; other site
700598012591	arginine finger; other site
700598012592	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
700598012593	putative hydrophobic ligand binding site [chemical binding]; other site
700598012594	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
700598012595	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
700598012596	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598012597	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
700598012598	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
700598012599	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
700598012600	FAD binding domain; Region: FAD_binding_4; pfam01565
700598012601	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
700598012602	PLD-like domain; Region: PLDc_2; pfam13091
700598012603	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
700598012604	putative active site [active]
700598012605	catalytic site [active]
700598012606	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
700598012607	putative active site [active]
700598012608	catalytic site [active]
700598012609	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598012610	NAD(P) binding site [chemical binding]; other site
700598012611	active site
700598012612	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
700598012613	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598012614	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
700598012615	active site
700598012616	Cytochrome P450; Region: p450; cl12078
700598012617	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700598012618	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
700598012619	active site
700598012620	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
700598012621	SnoaL-like domain; Region: SnoaL_2; pfam12680
700598012622	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
700598012623	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
700598012624	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
700598012625	putative acyl-acceptor binding pocket; other site
700598012626	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
700598012627	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700598012628	putative di-iron ligands [ion binding]; other site
700598012629	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
700598012630	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
700598012631	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
700598012632	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598012633	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598012634	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598012635	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598012636	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700598012637	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598012638	substrate binding pocket [chemical binding]; other site
700598012639	O-methyltransferase; Region: Methyltransf_2; pfam00891
700598012640	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
700598012641	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598012642	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598012643	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598012644	DNA binding residues [nucleotide binding]
700598012645	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
700598012646	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598012647	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598012648	catalytic residues [active]
700598012649	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598012650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598012651	active site
700598012652	phosphorylation site [posttranslational modification]
700598012653	intermolecular recognition site; other site
700598012654	dimerization interface [polypeptide binding]; other site
700598012655	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598012656	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598012657	putative active site [active]
700598012658	heme pocket [chemical binding]; other site
700598012659	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
700598012660	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598012661	putative active site [active]
700598012662	heme pocket [chemical binding]; other site
700598012663	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598012664	dimer interface [polypeptide binding]; other site
700598012665	phosphorylation site [posttranslational modification]
700598012666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598012667	ATP binding site [chemical binding]; other site
700598012668	Mg2+ binding site [ion binding]; other site
700598012669	G-X-G motif; other site
700598012670	rod shape-determining protein MreB; Provisional; Region: PRK13930
700598012671	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
700598012672	nucleotide binding site [chemical binding]; other site
700598012673	putative NEF/HSP70 interaction site [polypeptide binding]; other site
700598012674	SBD interface [polypeptide binding]; other site
700598012675	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700598012676	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598012677	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700598012678	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598012679	Walker A/P-loop; other site
700598012680	ATP binding site [chemical binding]; other site
700598012681	Q-loop/lid; other site
700598012682	ABC transporter signature motif; other site
700598012683	Walker B; other site
700598012684	D-loop; other site
700598012685	H-loop/switch region; other site
700598012686	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
700598012687	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598012688	FtsX-like permease family; Region: FtsX; pfam02687
700598012689	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598012690	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700598012691	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
700598012692	putative active site [active]
700598012693	putative metal binding site [ion binding]; other site
700598012694	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
700598012695	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598012696	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
700598012697	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
700598012698	conserved cys residue [active]
700598012699	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598012700	YCII-related domain; Region: YCII; cl00999
700598012701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598012702	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
700598012703	NAD(P) binding site [chemical binding]; other site
700598012704	active site
700598012705	GAF domain; Region: GAF; cl17456
700598012706	GAF domain; Region: GAF_2; pfam13185
700598012707	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700598012708	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
700598012709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598012710	ATP binding site [chemical binding]; other site
700598012711	Walker B motif; other site
700598012712	arginine finger; other site
700598012713	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
700598012714	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
700598012715	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
700598012716	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598012717	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598012718	FtsX-like permease family; Region: FtsX; pfam02687
700598012719	tRNAHis guanylyltransferase; Region: Thg1; pfam04446
700598012720	Uncharacterized conserved protein [Function unknown]; Region: COG4021
700598012721	Thg1 C terminal domain; Region: Thg1C; pfam14413
700598012722	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598012723	Ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal region...; Region: FNR_like_1; cd06196
700598012724	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700598012725	FAD binding pocket [chemical binding]; other site
700598012726	FAD binding motif [chemical binding]; other site
700598012727	phosphate binding motif [ion binding]; other site
700598012728	beta-alpha-beta structure motif; other site
700598012729	NAD binding pocket [chemical binding]; other site
700598012730	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
700598012731	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598012732	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598012733	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598012734	SusD family; Region: SusD; pfam07980
700598012735	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598012736	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598012737	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598012738	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598012739	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598012740	FecR protein; Region: FecR; pfam04773
700598012741	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598012742	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598012743	DNA binding residues [nucleotide binding]
700598012744	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700598012745	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598012746	NAD(P) binding site [chemical binding]; other site
700598012747	active site
700598012748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598012749	putative substrate translocation pore; other site
700598012750	Alginate lyase; Region: Alginate_lyase2; pfam08787
700598012751	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598012752	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598012753	Cupin domain; Region: Cupin_2; pfam07883
700598012754	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
700598012755	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
700598012756	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
700598012757	Transcriptional regulators [Transcription]; Region: FadR; COG2186
700598012758	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598012759	DNA-binding site [nucleotide binding]; DNA binding site
700598012760	FCD domain; Region: FCD; pfam07729
700598012761	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598012762	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598012763	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598012764	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012765	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598012766	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
700598012767	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598012768	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
700598012769	active site
700598012770	catalytic triad [active]
700598012771	oxyanion hole [active]
700598012772	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
700598012773	active site
700598012774	catalytic triad [active]
700598012775	oxyanion hole [active]
700598012776	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
700598012777	Na binding site [ion binding]; other site
700598012778	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
700598012779	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
700598012780	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
700598012781	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598012782	SusD family; Region: SusD; pfam07980
700598012783	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598012784	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012785	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598012786	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
700598012787	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
700598012788	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
700598012789	dimerization interface [polypeptide binding]; other site
700598012790	putative active cleft [active]
700598012791	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
700598012792	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
700598012793	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700598012794	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700598012795	nucleotide binding site [chemical binding]; other site
700598012796	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598012797	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598012798	DNA binding site [nucleotide binding]
700598012799	domain linker motif; other site
700598012800	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598012801	dimerization interface [polypeptide binding]; other site
700598012802	ligand binding site [chemical binding]; other site
700598012803	hypothetical protein; Provisional; Region: PRK07208
700598012804	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700598012805	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598012806	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598012807	DNA binding site [nucleotide binding]
700598012808	domain linker motif; other site
700598012809	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598012810	dimerization interface [polypeptide binding]; other site
700598012811	ligand binding site [chemical binding]; other site
700598012812	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
700598012813	Galactose oxidase, central domain; Region: Kelch_3; cl02701
700598012814	Kelch motif; Region: Kelch_1; pfam01344
700598012815	N-terminal domain of PARMER_03128; Region: PARMER_03128_N; cd12106
700598012816	Bacterial proteins similar to Porphyromonas gingivalis HmuY and the C-terminal domain of PARMER_03218; Region: HmuY_like; cd07472
700598012817	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
700598012818	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598012819	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598012820	SusD family; Region: SusD; pfam07980
700598012821	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598012822	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012823	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598012824	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
700598012825	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
700598012826	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
700598012828	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
700598012829	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
700598012830	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700598012831	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
700598012832	inhibitor site; inhibition site
700598012833	active site
700598012834	dimer interface [polypeptide binding]; other site
700598012835	catalytic residue [active]
700598012836	Cupin domain; Region: Cupin_2; cl17218
700598012837	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598012838	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598012839	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012840	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012841	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598012842	ligand binding site [chemical binding]; other site
700598012843	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598012844	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598012845	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
700598012846	putative active site [active]
700598012847	heme pocket [chemical binding]; other site
700598012848	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598012849	dimer interface [polypeptide binding]; other site
700598012850	phosphorylation site [posttranslational modification]
700598012851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598012852	ATP binding site [chemical binding]; other site
700598012853	Mg2+ binding site [ion binding]; other site
700598012854	G-X-G motif; other site
700598012855	Response regulator receiver domain; Region: Response_reg; pfam00072
700598012856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598012857	active site
700598012858	phosphorylation site [posttranslational modification]
700598012859	intermolecular recognition site; other site
700598012860	dimerization interface [polypeptide binding]; other site
700598012861	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
700598012862	putative binding surface; other site
700598012863	active site
700598012864	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598012865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598012866	active site
700598012867	phosphorylation site [posttranslational modification]
700598012868	intermolecular recognition site; other site
700598012869	dimerization interface [polypeptide binding]; other site
700598012870	LytTr DNA-binding domain; Region: LytTR; smart00850
700598012871	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
700598012872	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598012873	Beta-Casp domain; Region: Beta-Casp; smart01027
700598012874	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
700598012875	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700598012876	CoenzymeA binding site [chemical binding]; other site
700598012877	subunit interaction site [polypeptide binding]; other site
700598012878	PHB binding site; other site
700598012879	diaminopimelate decarboxylase; Region: lysA; TIGR01048
700598012880	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
700598012881	active site
700598012882	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700598012883	substrate binding site [chemical binding]; other site
700598012884	catalytic residues [active]
700598012885	dimer interface [polypeptide binding]; other site
700598012886	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
700598012887	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
700598012888	core domain interface [polypeptide binding]; other site
700598012889	delta subunit interface [polypeptide binding]; other site
700598012890	epsilon subunit interface [polypeptide binding]; other site
700598012891	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
700598012892	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598012893	NAD(P) binding site [chemical binding]; other site
700598012894	active site
700598012895	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
700598012896	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
700598012897	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
700598012898	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
700598012899	active site
700598012900	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
700598012901	heme-binding site [chemical binding]; other site
700598012902	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
700598012903	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700598012904	Walker A/P-loop; other site
700598012905	ATP binding site [chemical binding]; other site
700598012906	Q-loop/lid; other site
700598012907	ABC transporter signature motif; other site
700598012908	Walker B; other site
700598012909	D-loop; other site
700598012910	H-loop/switch region; other site
700598012911	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
700598012912	NosL; Region: NosL; cl01769
700598012913	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
700598012914	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
700598012915	Cytochrome c; Region: Cytochrom_C; pfam00034
700598012916	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598012917	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598012918	ligand binding site [chemical binding]; other site
700598012919	flexible hinge region; other site
700598012920	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700598012921	putative switch regulator; other site
700598012922	non-specific DNA interactions [nucleotide binding]; other site
700598012923	DNA binding site [nucleotide binding]
700598012924	sequence specific DNA binding site [nucleotide binding]; other site
700598012925	putative cAMP binding site [chemical binding]; other site
700598012926	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
700598012927	dimerization interface [polypeptide binding]; other site
700598012928	metal binding site [ion binding]; metal-binding site
700598012929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598012930	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598012931	putative substrate translocation pore; other site
700598012932	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
700598012933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598012934	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598012935	putative substrate translocation pore; other site
700598012936	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
700598012937	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
700598012938	active site
700598012939	intersubunit interface [polypeptide binding]; other site
700598012940	catalytic residue [active]
700598012941	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700598012942	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
700598012943	substrate binding site [chemical binding]; other site
700598012944	ATP binding site [chemical binding]; other site
700598012945	Glucuronate isomerase; Region: UxaC; pfam02614
700598012946	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
700598012947	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
700598012948	galactarate dehydratase; Region: galactar-dH20; TIGR03248
700598012949	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
700598012950	altronate oxidoreductase; Provisional; Region: PRK03643
700598012951	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
700598012952	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
700598012953	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
700598012954	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
700598012955	Right handed beta helix region; Region: Beta_helix; pfam13229
700598012956	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598012957	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598012958	SusD family; Region: SusD; pfam07980
700598012959	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598012960	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598012961	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012962	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598012963	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598012964	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598012965	FecR protein; Region: FecR; pfam04773
700598012966	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598012967	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598012968	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598012969	DNA binding residues [nucleotide binding]
700598012970	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
700598012971	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
700598012972	active site
700598012973	putative pectinesterase; Region: PLN02432; cl01911
700598012974	Pectinesterase; Region: Pectinesterase; pfam01095
700598012975	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598012976	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598012977	Pectate lyase; Region: Pec_lyase_C; cl01593
700598012978	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
700598012979	Pectinesterase; Region: Pectinesterase; pfam01095
700598012980	putative pectinesterase; Region: PLN02432; cl01911
700598012981	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598012982	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
700598012983	active site
700598012984	catalytic triad [active]
700598012985	Pectate lyase; Region: Pec_lyase_C; cl01593
700598012986	Right handed beta helix region; Region: Beta_helix; pfam13229
700598012987	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598012988	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598012989	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598012990	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598012991	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598012992	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598012993	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598012994	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598012995	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598012996	DNA binding site [nucleotide binding]
700598012997	domain linker motif; other site
700598012998	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598012999	ligand binding site [chemical binding]; other site
700598013000	dimerization interface [polypeptide binding]; other site
700598013001	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
700598013002	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700598013003	active site
700598013004	dimer interface [polypeptide binding]; other site
700598013005	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
700598013006	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598013007	DNA-binding site [nucleotide binding]; DNA binding site
700598013008	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598013009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598013010	homodimer interface [polypeptide binding]; other site
700598013011	catalytic residue [active]
700598013012	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
700598013013	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
700598013014	GTP binding site; other site
700598013015	Rdx family; Region: Rdx; cl01407
700598013016	Rubredoxin; Region: Rubredoxin; pfam00301
700598013017	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
700598013018	iron binding site [ion binding]; other site
700598013019	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
700598013020	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
700598013021	[4Fe-4S] binding site [ion binding]; other site
700598013022	molybdopterin cofactor binding site; other site
700598013023	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
700598013024	molybdopterin cofactor binding site; other site
700598013025	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
700598013026	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700598013027	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
700598013028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598013029	putative substrate translocation pore; other site
700598013030	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
700598013031	nitrite reductase subunit NirD; Provisional; Region: PRK14989
700598013032	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598013033	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700598013034	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
700598013035	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
700598013036	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
700598013037	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598013038	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598013039	ligand binding site [chemical binding]; other site
700598013040	flexible hinge region; other site
700598013041	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700598013042	putative switch regulator; other site
700598013043	non-specific DNA interactions [nucleotide binding]; other site
700598013044	DNA binding site [nucleotide binding]
700598013045	sequence specific DNA binding site [nucleotide binding]; other site
700598013046	putative cAMP binding site [chemical binding]; other site
700598013047	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
700598013048	active site
700598013049	SAM binding site [chemical binding]; other site
700598013050	homodimer interface [polypeptide binding]; other site
700598013051	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
700598013052	YtxH-like protein; Region: YtxH; cl02079
700598013053	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
700598013054	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
700598013055	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598013056	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598013057	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
700598013058	putative active site [active]
700598013059	putative metal binding site [ion binding]; other site
700598013060	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
700598013061	trimer interface [polypeptide binding]; other site
700598013062	active site
700598013063	substrate binding site [chemical binding]; other site
700598013064	CoA binding site [chemical binding]; other site
700598013065	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
700598013066	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
700598013067	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
700598013068	NAD(P) binding site [chemical binding]; other site
700598013069	homodimer interface [polypeptide binding]; other site
700598013070	substrate binding site [chemical binding]; other site
700598013071	active site
700598013072	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
700598013073	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
700598013074	inhibitor-cofactor binding pocket; inhibition site
700598013075	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598013076	catalytic residue [active]
700598013077	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
700598013078	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
700598013079	putative trimer interface [polypeptide binding]; other site
700598013080	putative CoA binding site [chemical binding]; other site
700598013081	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
700598013082	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
700598013083	inhibitor-cofactor binding pocket; inhibition site
700598013084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598013085	catalytic residue [active]
700598013086	Bacterial sugar transferase; Region: Bac_transf; pfam02397
700598013087	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
700598013088	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598013089	putative ADP-binding pocket [chemical binding]; other site
700598013090	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598013091	Coenzyme A binding pocket [chemical binding]; other site
700598013092	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929
700598013093	putative active site [active]
700598013094	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598013095	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598013096	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598013097	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
700598013098	putative ADP-binding pocket [chemical binding]; other site
700598013099	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598013100	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
700598013101	putative ADP-binding pocket [chemical binding]; other site
700598013102	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
700598013103	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
700598013104	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598013105	active site
700598013106	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
700598013107	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598013108	active site
700598013109	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
700598013110	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598013111	active site
700598013112	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
700598013113	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598013114	active site
700598013115	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700598013116	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598013117	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598013118	active site
700598013119	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
700598013120	WbqC-like protein family; Region: WbqC; pfam08889
700598013121	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
700598013122	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
700598013123	inhibitor-cofactor binding pocket; inhibition site
700598013124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598013125	catalytic residue [active]
700598013126	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598013127	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700598013128	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598013129	Walker A/P-loop; other site
700598013130	ATP binding site [chemical binding]; other site
700598013131	Q-loop/lid; other site
700598013132	ABC transporter signature motif; other site
700598013133	Walker B; other site
700598013134	D-loop; other site
700598013135	H-loop/switch region; other site
700598013136	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
700598013137	Chain length determinant protein; Region: Wzz; cl15801
700598013138	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
700598013139	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
700598013140	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
700598013141	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
700598013142	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
700598013143	NAD binding site [chemical binding]; other site
700598013144	substrate binding site [chemical binding]; other site
700598013145	homodimer interface [polypeptide binding]; other site
700598013146	active site
700598013147	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
700598013148	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
700598013149	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
700598013150	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
700598013151	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
700598013152	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
700598013153	homodimer interface [polypeptide binding]; other site
700598013154	mannonate dehydratase; Provisional; Region: PRK03906
700598013155	mannonate dehydratase; Region: uxuA; TIGR00695
700598013156	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598013157	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598013158	DNA binding site [nucleotide binding]
700598013159	domain linker motif; other site
700598013160	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598013161	dimerization interface [polypeptide binding]; other site
700598013162	ligand binding site [chemical binding]; other site
700598013163	Rhomboid family; Region: Rhomboid; pfam01694
700598013164	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700598013165	Cupin domain; Region: Cupin_2; pfam07883
700598013166	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598013167	Domain of unknown function (DUF386); Region: DUF386; cl01047
700598013168	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
700598013169	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598013170	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
700598013171	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
700598013172	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598013173	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
700598013174	Alginate lyase; Region: Alginate_lyase; pfam05426
700598013175	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
700598013176	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
700598013177	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
700598013178	active site
700598013179	catalytic site [active]
700598013180	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700598013181	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598013182	beta-D-glucuronidase; Provisional; Region: PRK10150
700598013183	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598013184	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598013185	Fasciclin domain; Region: Fasciclin; cl02663
700598013186	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598013187	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598013188	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598013189	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598013190	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598013191	Nop14-like family; Region: Nop14; pfam04147
700598013192	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
700598013193	Melibiase; Region: Melibiase; pfam02065
700598013194	Alginate lyase; Region: Alginate_lyase; pfam05426
700598013195	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
700598013196	putative active site [active]
700598013197	putative metal binding residues [ion binding]; other site
700598013198	signature motif; other site
700598013199	putative dimer interface [polypeptide binding]; other site
700598013200	putative phosphate binding site [ion binding]; other site
700598013201	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
700598013202	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700598013203	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598013204	motif II; other site
700598013205	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598013206	TPR motif; other site
700598013207	TPR repeat; Region: TPR_11; pfam13414
700598013208	binding surface
700598013209	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
700598013210	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
700598013211	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
700598013212	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
700598013213	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598013214	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598013215	SusD family; Region: SusD; pfam07980
700598013216	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598013217	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598013218	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598013219	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598013220	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
700598013221	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
700598013222	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598013223	SusD family; Region: SusD; pfam07980
700598013224	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598013225	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598013226	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598013227	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
700598013228	Catalytic site [active]
700598013229	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
700598013230	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
700598013231	active site
700598013232	DNA binding site [nucleotide binding]
700598013233	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
700598013234	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
700598013235	NHL repeat; Region: NHL; pfam01436
700598013236	NHL repeat; Region: NHL; pfam01436
700598013237	NHL repeat; Region: NHL; pfam01436
700598013238	NHL repeat; Region: NHL; pfam01436
700598013239	NHL repeat; Region: NHL; pfam01436
700598013240	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
700598013241	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598013242	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
700598013243	proline aminopeptidase P II; Provisional; Region: PRK10879
700598013244	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
700598013245	active site
700598013246	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
700598013247	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
700598013248	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598013249	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598013250	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598013251	DNA binding residues [nucleotide binding]
700598013252	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598013253	FecR protein; Region: FecR; pfam04773
700598013254	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598013255	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598013256	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
700598013257	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
700598013258	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
700598013259	catalytic residues [active]
700598013260	catalytic nucleophile [active]
700598013261	Recombinase; Region: Recombinase; pfam07508
700598013262	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
700598013263	Helix-turn-helix domain; Region: HTH_17; pfam12728
700598013264	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598013265	non-specific DNA binding site [nucleotide binding]; other site
700598013266	salt bridge; other site
700598013267	sequence-specific DNA binding site [nucleotide binding]; other site
700598013268	HEPN domain; Region: HEPN; pfam05168
700598013269	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598013270	non-specific DNA binding site [nucleotide binding]; other site
700598013271	salt bridge; other site
700598013272	sequence-specific DNA binding site [nucleotide binding]; other site
700598013273	AAA domain; Region: AAA_21; pfam13304
700598013274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598013275	ABC transporter signature motif; other site
700598013276	Walker B; other site
700598013277	D-loop; other site
700598013278	TIGR02646 family protein; Region: TIGR02646
700598013279	Nuclease-related domain; Region: NERD; pfam08378
700598013280	AAA domain; Region: AAA_22; pfam13401
700598013281	Part of AAA domain; Region: AAA_19; pfam13245
700598013282	Family description; Region: UvrD_C_2; pfam13538
700598013283	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
700598013284	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598013285	ATP binding site [chemical binding]; other site
700598013286	putative Mg++ binding site [ion binding]; other site
700598013287	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598013288	nucleotide binding region [chemical binding]; other site
700598013289	ATP-binding site [chemical binding]; other site
700598013290	Nuclease-related domain; Region: NERD; pfam08378
700598013291	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
700598013292	PLD-like domain; Region: PLDc_2; pfam13091
700598013293	homodimer interface [polypeptide binding]; other site
700598013294	putative active site [active]
700598013295	catalytic site [active]
700598013296	DEAD-like helicases superfamily; Region: DEXDc; smart00487
700598013297	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
700598013298	ATP binding site [chemical binding]; other site
700598013299	putative Mg++ binding site [ion binding]; other site
700598013300	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598013301	nucleotide binding region [chemical binding]; other site
700598013302	ATP-binding site [chemical binding]; other site
700598013303	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
700598013304	aspartate racemase; Region: asp_race; TIGR00035
700598013305	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
700598013306	homodimer interface [polypeptide binding]; other site
700598013307	helix swapped region; other site
700598013308	substrate binding pocket [chemical binding]; other site
700598013309	catalytic residues [active]
700598013310	NADH/NADPH cofactor binding site [chemical binding]; other site
700598013311	Phosphotransferase enzyme family; Region: APH; pfam01636
700598013312	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700598013313	active site
700598013314	ATP binding site [chemical binding]; other site
700598013315	substrate binding site [chemical binding]; other site
700598013316	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
700598013317	G1 box; other site
700598013318	GTP/Mg2+ binding site [chemical binding]; other site
700598013319	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
700598013320	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
700598013321	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
700598013322	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
700598013323	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
700598013324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598013325	TPR motif; other site
700598013326	binding surface
700598013327	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598013328	binding surface
700598013329	TPR motif; other site
700598013330	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598013331	binding surface
700598013332	TPR motif; other site
700598013333	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598013334	TPR motif; other site
700598013335	binding surface
700598013336	TPR repeat; Region: TPR_11; pfam13414
700598013337	Tetratricopeptide repeat; Region: TPR_17; pfam13431
700598013338	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598013339	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
700598013340	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598013341	Serine hydrolase; Region: Ser_hydrolase; cl17834
700598013342	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
700598013343	Histidine kinase; Region: His_kinase; pfam06580
700598013344	Response regulator receiver domain; Region: Response_reg; pfam00072
700598013345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598013346	active site
700598013347	phosphorylation site [posttranslational modification]
700598013348	intermolecular recognition site; other site
700598013349	dimerization interface [polypeptide binding]; other site
700598013350	LytTr DNA-binding domain; Region: LytTR; pfam04397
700598013351	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598013352	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598013353	short chain dehydrogenase; Provisional; Region: PRK06500
700598013354	classical (c) SDRs; Region: SDR_c; cd05233
700598013355	NAD(P) binding site [chemical binding]; other site
700598013356	active site
700598013357	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
700598013358	citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793
700598013359	oxalacetate binding site [chemical binding]; other site
700598013360	citrylCoA binding site [chemical binding]; other site
700598013361	coenzyme A binding site [chemical binding]; other site
700598013362	catalytic triad [active]
700598013363	Predicted permeases [General function prediction only]; Region: COG0795
700598013364	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
700598013365	Predicted peptidase [General function prediction only]; Region: COG4099
700598013366	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598013367	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
700598013368	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
700598013369	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
700598013370	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598013371	active site
700598013372	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
700598013373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598013374	S-adenosylmethionine binding site [chemical binding]; other site
700598013375	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598013376	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598013377	active site
700598013378	phosphorylation site [posttranslational modification]
700598013379	intermolecular recognition site; other site
700598013380	dimerization interface [polypeptide binding]; other site
700598013381	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598013382	DNA binding residues [nucleotide binding]
700598013383	dimerization interface [polypeptide binding]; other site
700598013384	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
700598013385	Zn binding site [ion binding]; other site
700598013386	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
700598013387	Predicted methyltransferases [General function prediction only]; Region: COG0313
700598013388	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
700598013389	putative SAM binding site [chemical binding]; other site
700598013390	putative homodimer interface [polypeptide binding]; other site
700598013391	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
700598013392	four helix bundle protein; Region: TIGR02436
700598013393	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
700598013394	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
700598013395	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
700598013396	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
700598013397	proline aminopeptidase P II; Provisional; Region: PRK10879
700598013398	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
700598013399	active site
700598013400	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
700598013401	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
700598013402	active site
700598013403	substrate-binding site [chemical binding]; other site
700598013404	metal-binding site [ion binding]
700598013405	ATP binding site [chemical binding]; other site
700598013406	Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415
700598013407	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
700598013408	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
700598013409	Substrate-binding site [chemical binding]; other site
700598013410	Substrate specificity [chemical binding]; other site
700598013411	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
700598013412	active site
700598013413	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
700598013414	HIGH motif; other site
700598013415	dimer interface [polypeptide binding]; other site
700598013416	KMSKS motif; other site
700598013417	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
700598013418	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700598013419	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700598013420	Walker A/P-loop; other site
700598013421	ATP binding site [chemical binding]; other site
700598013422	Q-loop/lid; other site
700598013423	ABC transporter signature motif; other site
700598013424	Walker B; other site
700598013425	D-loop; other site
700598013426	H-loop/switch region; other site
700598013427	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
700598013428	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700598013429	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700598013430	Walker A/P-loop; other site
700598013431	ATP binding site [chemical binding]; other site
700598013432	Q-loop/lid; other site
700598013433	ABC transporter signature motif; other site
700598013434	Walker B; other site
700598013435	D-loop; other site
700598013436	H-loop/switch region; other site
700598013437	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
700598013438	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598013439	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
700598013440	NAD(P) binding site [chemical binding]; other site
700598013441	active site
700598013442	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
700598013443	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
700598013444	Walker A/P-loop; other site
700598013445	ATP binding site [chemical binding]; other site
700598013446	Q-loop/lid; other site
700598013447	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
700598013448	ABC transporter signature motif; other site
700598013449	Walker B; other site
700598013450	D-loop; other site
700598013451	H-loop/switch region; other site
700598013452	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
700598013453	Putative zinc ribbon domain; Region: DUF164; pfam02591
700598013454	Uncharacterized conserved protein [Function unknown]; Region: COG0327
700598013455	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
700598013456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
700598013457	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
700598013458	MG2 domain; Region: A2M_N; pfam01835
700598013459	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
700598013460	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
700598013461	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
700598013462	THF binding site; other site
700598013463	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
700598013464	substrate binding site [chemical binding]; other site
700598013465	THF binding site; other site
700598013466	zinc-binding site [ion binding]; other site
700598013467	ribonucleoside--diphosphate reductase large subunit; Region: PLN02437
700598013468	ATP cone domain; Region: ATP-cone; pfam03477
700598013469	Class I ribonucleotide reductase; Region: RNR_I; cd01679
700598013470	active site
700598013471	dimer interface [polypeptide binding]; other site
700598013472	catalytic residues [active]
700598013473	effector binding site; other site
700598013474	R2 peptide binding site; other site
700598013475	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
700598013476	dimer interface [polypeptide binding]; other site
700598013477	putative radical transfer pathway; other site
700598013478	diiron center [ion binding]; other site
700598013479	tyrosyl radical; other site
700598013480	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
700598013481	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
700598013482	active site
700598013483	Zn binding site [ion binding]; other site
700598013484	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598013485	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598013486	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598013487	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598013488	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598013489	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598013490	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598013491	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598013492	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
700598013493	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
700598013494	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598013495	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598013496	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598013497	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
700598013498	alpha-galactosidase; Region: PLN02808; cl17638
700598013499	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
700598013500	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Bcp; COG1225
700598013501	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598013502	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
700598013503	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
700598013504	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
700598013505	putative RNA binding site [nucleotide binding]; other site
700598013506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598013507	S-adenosylmethionine binding site [chemical binding]; other site
700598013508	Family description; Region: VCBS; pfam13517
700598013509	Family description; Region: VCBS; pfam13517
700598013510	Family description; Region: VCBS; pfam13517
700598013511	Family description; Region: VCBS; pfam13517
700598013512	Family description; Region: VCBS; pfam13517
700598013513	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
700598013514	Family description; Region: VCBS; pfam13517
700598013515	Family description; Region: VCBS; pfam13517
700598013516	Family description; Region: VCBS; pfam13517
700598013517	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598013518	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598013519	SusD family; Region: SusD; pfam07980
700598013520	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598013521	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598013522	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598013523	GrpE; Region: GrpE; pfam01025
700598013524	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
700598013525	dimer interface [polypeptide binding]; other site
700598013526	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
700598013527	chaperone protein DnaJ; Provisional; Region: PRK14289
700598013528	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
700598013529	HSP70 interaction site [polypeptide binding]; other site
700598013530	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
700598013531	substrate binding site [polypeptide binding]; other site
700598013532	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
700598013533	Zn binding sites [ion binding]; other site
700598013534	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
700598013535	dimer interface [polypeptide binding]; other site
700598013536	von Willebrand factor; Region: vWF_A; pfam12450
700598013537	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
700598013538	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
700598013539	metal ion-dependent adhesion site (MIDAS); other site
700598013540	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
700598013541	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700598013542	active site
700598013543	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
700598013544	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
700598013545	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
700598013546	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
700598013547	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
700598013548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598013549	S-adenosylmethionine binding site [chemical binding]; other site
700598013550	putative transporter; Provisional; Region: PRK10484
700598013551	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
700598013552	Na binding site [ion binding]; other site
700598013553	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
700598013554	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598013555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598013556	active site
700598013557	phosphorylation site [posttranslational modification]
700598013558	intermolecular recognition site; other site
700598013559	dimerization interface [polypeptide binding]; other site
700598013560	Bacterial sugar transferase; Region: Bac_transf; pfam02397
700598013561	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
700598013562	gamma subunit interface [polypeptide binding]; other site
700598013563	LBP interface [polypeptide binding]; other site
700598013564	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
700598013565	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
700598013566	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
700598013567	alpha subunit interaction interface [polypeptide binding]; other site
700598013568	Walker A motif; other site
700598013569	ATP binding site [chemical binding]; other site
700598013570	Walker B motif; other site
700598013571	inhibitor binding site; inhibition site
700598013572	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
700598013573	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598013574	Protein export membrane protein; Region: SecD_SecF; cl14618
700598013575	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598013576	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598013577	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598013578	Outer membrane efflux protein; Region: OEP; pfam02321
700598013579	Outer membrane efflux protein; Region: OEP; pfam02321
700598013580	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598013581	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598013582	WHG domain; Region: WHG; pfam13305
700598013583	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
700598013584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598013585	Walker A motif; other site
700598013586	ATP binding site [chemical binding]; other site
700598013587	Walker B motif; other site
700598013588	arginine finger; other site
700598013589	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
700598013590	Peptidase family M48; Region: Peptidase_M48; cl12018
700598013591	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700598013592	E3 interaction surface; other site
700598013593	lipoyl attachment site [posttranslational modification]; other site
700598013594	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
700598013595	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700598013596	E3 interaction surface; other site
700598013597	lipoyl attachment site [posttranslational modification]; other site
700598013598	e3 binding domain; Region: E3_binding; pfam02817
700598013599	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
700598013600	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598013601	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598013602	active site
700598013603	metal binding site [ion binding]; metal-binding site
700598013604	PQQ-like domain; Region: PQQ_2; pfam13360
700598013605	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
700598013606	active site
700598013607	Trp docking motif [polypeptide binding]; other site
700598013608	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
700598013609	UbiA prenyltransferase family; Region: UbiA; pfam01040
700598013610	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
700598013611	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
700598013612	malonyl-CoA binding site [chemical binding]; other site
700598013613	dimer interface [polypeptide binding]; other site
700598013614	active site
700598013615	product binding site; other site
700598013616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598013617	S-adenosylmethionine binding site [chemical binding]; other site
700598013618	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
700598013619	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
700598013620	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
700598013621	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
700598013622	Predicted transcriptional regulators [Transcription]; Region: COG1510
700598013623	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598013624	putative DNA binding site [nucleotide binding]; other site
700598013625	putative Zn2+ binding site [ion binding]; other site
700598013626	Protein of unknown function, DUF393; Region: DUF393; cl01136
700598013627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598013628	TIGR01777 family protein; Region: yfcH
700598013629	NAD(P) binding site [chemical binding]; other site
700598013630	active site
700598013631	CoA binding domain; Region: CoA_binding_2; pfam13380
700598013632	3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640
700598013633	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
700598013634	active site
700598013635	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598013636	Protein of unknown function (DUF458); Region: DUF458; cl00861
700598013637	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
700598013638	G1 box; other site
700598013639	GTP/Mg2+ binding site [chemical binding]; other site
700598013640	Switch I region; other site
700598013641	G2 box; other site
700598013642	G3 box; other site
700598013643	Switch II region; other site
700598013644	G4 box; other site
700598013645	G5 box; other site
700598013646	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
700598013647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598013648	S-adenosylmethionine binding site [chemical binding]; other site
700598013649	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598013650	Cytochrome c; Region: Cytochrom_C; cl11414
700598013651	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598013652	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598013653	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598013654	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598013655	binding surface
700598013656	TPR motif; other site
700598013657	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598013658	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
700598013659	Histidine kinase; Region: HisKA_2; pfam07568
700598013660	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598013661	ATP binding site [chemical binding]; other site
700598013662	Mg2+ binding site [ion binding]; other site
700598013663	G-X-G motif; other site
700598013664	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598013665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598013666	active site
700598013667	phosphorylation site [posttranslational modification]
700598013668	intermolecular recognition site; other site
700598013669	dimerization interface [polypeptide binding]; other site
700598013670	LytTr DNA-binding domain; Region: LytTR; smart00850
700598013671	dihydroorotase; Reviewed; Region: PRK09236
700598013672	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598013673	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
700598013674	active site
700598013675	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598013676	Walker A/P-loop; other site
700598013677	ATP binding site [chemical binding]; other site
700598013678	Q-loop/lid; other site
700598013679	ABC transporter signature motif; other site
700598013680	Walker B; other site
700598013681	D-loop; other site
700598013682	H-loop/switch region; other site
700598013683	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
700598013684	Zn binding site [ion binding]; other site
700598013685	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
700598013686	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
700598013687	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598013688	Walker A motif; other site
700598013689	ATP binding site [chemical binding]; other site
700598013690	Walker B motif; other site
700598013691	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
700598013692	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598013693	active site
700598013694	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598013695	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598013696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598013697	S-adenosylmethionine binding site [chemical binding]; other site
700598013698	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
700598013699	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
700598013700	Probable Catalytic site; other site
700598013701	metal-binding site
700598013702	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598013703	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598013704	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
700598013705	TPP-binding site [chemical binding]; other site
700598013706	dimer interface [polypeptide binding]; other site
700598013707	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
700598013708	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700598013709	PYR/PP interface [polypeptide binding]; other site
700598013710	dimer interface [polypeptide binding]; other site
700598013711	TPP binding site [chemical binding]; other site
700598013712	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598013713	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598013714	NAD(P) binding site [chemical binding]; other site
700598013715	active site
700598013716	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
700598013717	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
700598013718	Ligand binding site; other site
700598013719	Putative Catalytic site; other site
700598013720	DXD motif; other site
700598013721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598013722	S-adenosylmethionine binding site [chemical binding]; other site
700598013723	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
700598013724	Methyltransferase domain; Region: Methyltransf_11; pfam08241
700598013725	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700598013726	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598013727	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598013728	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
700598013729	active site
700598013730	ABC-2 type transporter; Region: ABC2_membrane; cl17235
700598013731	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
700598013732	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
700598013733	Walker A/P-loop; other site
700598013734	ATP binding site [chemical binding]; other site
700598013735	Q-loop/lid; other site
700598013736	ABC transporter signature motif; other site
700598013737	Walker B; other site
700598013738	D-loop; other site
700598013739	H-loop/switch region; other site
700598013740	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598013741	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598013742	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598013743	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
700598013744	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
700598013745	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
700598013746	O-Antigen ligase; Region: Wzy_C; pfam04932
700598013747	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700598013748	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598013749	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598013750	Walker A/P-loop; other site
700598013751	ATP binding site [chemical binding]; other site
700598013752	Q-loop/lid; other site
700598013753	ABC transporter signature motif; other site
700598013754	Walker B; other site
700598013755	D-loop; other site
700598013756	H-loop/switch region; other site
700598013757	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
700598013758	Peptidase of plants and bacteria; Region: BSP; pfam04450
700598013759	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
700598013760	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
700598013761	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598013762	binding surface
700598013763	TPR motif; other site
700598013764	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598013765	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598013766	binding surface
700598013767	TPR motif; other site
700598013768	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598013769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598013770	binding surface
700598013771	TPR motif; other site
700598013772	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598013773	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598013774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598013775	dimer interface [polypeptide binding]; other site
700598013776	phosphorylation site [posttranslational modification]
700598013777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598013778	ATP binding site [chemical binding]; other site
700598013779	Mg2+ binding site [ion binding]; other site
700598013780	G-X-G motif; other site
700598013781	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598013782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598013783	active site
700598013784	phosphorylation site [posttranslational modification]
700598013785	intermolecular recognition site; other site
700598013786	dimerization interface [polypeptide binding]; other site
700598013787	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598013788	DNA binding residues [nucleotide binding]
700598013789	dimerization interface [polypeptide binding]; other site
700598013790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
700598013791	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598013792	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
700598013793	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
700598013794	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700598013795	dimer interface [polypeptide binding]; other site
700598013796	active site
700598013797	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
700598013798	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
700598013799	quinone interaction residues [chemical binding]; other site
700598013800	active site
700598013801	catalytic residues [active]
700598013802	FMN binding site [chemical binding]; other site
700598013803	substrate binding site [chemical binding]; other site
700598013804	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
700598013805	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
700598013806	RNA methyltransferase, RsmE family; Region: TIGR00046
700598013807	replicative DNA helicase; Region: DnaB; TIGR00665
700598013808	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
700598013809	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
700598013810	Walker A motif; other site
700598013811	ATP binding site [chemical binding]; other site
700598013812	Walker B motif; other site
700598013813	DNA binding loops [nucleotide binding]
700598013814	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
700598013815	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
700598013816	putative tRNA-binding site [nucleotide binding]; other site
700598013817	B3/4 domain; Region: B3_4; pfam03483
700598013818	tRNA synthetase B5 domain; Region: B5; pfam03484
700598013819	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
700598013820	dimer interface [polypeptide binding]; other site
700598013821	motif 1; other site
700598013822	motif 3; other site
700598013823	motif 2; other site
700598013824	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
700598013825	FlgD Tudor-like domain; Region: FLgD_tudor; cl17881
700598013826	Cell division protein ZapA; Region: ZapA; pfam05164
700598013827	phosphodiesterase; Provisional; Region: PRK12704
700598013828	KH domain; Region: KH_1; pfam00013
700598013829	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700598013830	Zn2+ binding site [ion binding]; other site
700598013831	Mg2+ binding site [ion binding]; other site
700598013832	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
700598013833	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
700598013834	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
700598013835	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
700598013836	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
700598013837	N-acetyl-D-glucosamine binding site [chemical binding]; other site
700598013838	catalytic residue [active]
700598013839	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
700598013840	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
700598013841	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
700598013842	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
700598013843	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
700598013844	GDP-binding site [chemical binding]; other site
700598013845	ACT binding site; other site
700598013846	IMP binding site; other site
700598013847	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
700598013848	HD domain; Region: HD_4; pfam13328
700598013849	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
700598013850	synthetase active site [active]
700598013851	NTP binding site [chemical binding]; other site
700598013852	metal binding site [ion binding]; metal-binding site
700598013853	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
700598013854	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
700598013855	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598013856	Ligand Binding Site [chemical binding]; other site
700598013857	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598013858	Ligand Binding Site [chemical binding]; other site
700598013859	trigger factor; Region: tig; TIGR00115
700598013860	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
700598013861	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598013862	dimerization interface [polypeptide binding]; other site
700598013863	putative DNA binding site [nucleotide binding]; other site
700598013864	putative Zn2+ binding site [ion binding]; other site
700598013865	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
700598013866	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
700598013867	active site
700598013868	catalytic triad [active]
700598013869	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
700598013870	CARDB; Region: CARDB; pfam07705
700598013871	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598013872	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
700598013873	EamA-like transporter family; Region: EamA; pfam00892
700598013874	EamA-like transporter family; Region: EamA; pfam00892
700598013875	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598013876	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
700598013877	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
700598013878	N-terminal plug; other site
700598013879	ligand-binding site [chemical binding]; other site
700598013880	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
700598013881	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
700598013882	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
700598013883	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
700598013884	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598013885	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598013886	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700598013887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598013888	binding surface
700598013889	TPR motif; other site
700598013890	CHAT domain; Region: CHAT; pfam12770
700598013891	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
700598013892	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700598013893	putative di-iron ligands [ion binding]; other site
700598013894	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
700598013895	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
700598013896	active site
700598013897	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700598013898	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
700598013899	NodB motif; other site
700598013900	putative active site [active]
700598013901	putative catalytic site [active]
700598013902	putative Zn binding site [ion binding]; other site
700598013903	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
700598013904	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
700598013905	HIGH motif; other site
700598013906	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
700598013907	active site
700598013908	KMSKS motif; other site
700598013909	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
700598013910	four helix bundle protein; Region: TIGR02436
700598013911	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
700598013912	B12 binding site [chemical binding]; other site
700598013913	cobalt ligand [ion binding]; other site
700598013914	enoyl-CoA hydratase; Provisional; Region: PRK07658
700598013915	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700598013916	substrate binding site [chemical binding]; other site
700598013917	oxyanion hole (OAH) forming residues; other site
700598013918	trimer interface [polypeptide binding]; other site
700598013919	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598013920	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598013921	DNA binding site [nucleotide binding]
700598013922	domain linker motif; other site
700598013923	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598013924	dimerization interface [polypeptide binding]; other site
700598013925	ligand binding site [chemical binding]; other site
700598013926	fumarate hydratase; Reviewed; Region: fumC; PRK00485
700598013927	Class II fumarases; Region: Fumarase_classII; cd01362
700598013928	active site
700598013929	tetramer interface [polypeptide binding]; other site
700598013930	lipoprotein signal peptidase; Provisional; Region: PRK14788
700598013931	lipoprotein signal peptidase; Provisional; Region: PRK14787
700598013932	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
700598013933	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
700598013934	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700598013935	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
700598013936	active site
700598013937	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700598013938	dimer interface [polypeptide binding]; other site
700598013939	substrate binding site [chemical binding]; other site
700598013940	catalytic residues [active]
700598013941	Integral membrane protein TerC family; Region: TerC; cl10468
700598013942	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
700598013943	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
700598013944	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
700598013945	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700598013946	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
700598013947	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598013948	catalytic residue [active]
700598013949	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598013950	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
700598013951	dimer interface [polypeptide binding]; other site
700598013952	substrate binding site [chemical binding]; other site
700598013953	metal binding site [ion binding]; metal-binding site
700598013954	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700598013955	MarR family; Region: MarR_2; pfam12802
700598013956	G8 domain; Region: G8; pfam10162
700598013957	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598013958	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
700598013959	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
700598013960	dimerization interface [polypeptide binding]; other site
700598013961	active site
700598013962	metal binding site [ion binding]; metal-binding site
700598013963	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
700598013964	dsRNA binding site [nucleotide binding]; other site
700598013965	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
700598013966	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
700598013967	dimer interface [polypeptide binding]; other site
700598013968	active site
700598013969	acyl carrier protein; Provisional; Region: acpP; PRK00982
700598013970	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598013971	Coenzyme A binding pocket [chemical binding]; other site
700598013972	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
700598013973	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
700598013974	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598013975	ATP binding site [chemical binding]; other site
700598013976	putative Mg++ binding site [ion binding]; other site
700598013977	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598013978	nucleotide binding region [chemical binding]; other site
700598013979	ATP-binding site [chemical binding]; other site
700598013980	TRCF domain; Region: TRCF; pfam03461
700598013981	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700598013982	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
700598013983	FAD binding pocket [chemical binding]; other site
700598013984	conserved FAD binding motif [chemical binding]; other site
700598013985	phosphate binding motif [ion binding]; other site
700598013986	beta-alpha-beta structure motif; other site
700598013987	NAD binding pocket [chemical binding]; other site
700598013988	glycyl-tRNA synthetase; Provisional; Region: PRK04173
700598013989	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700598013990	motif 1; other site
700598013991	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
700598013992	active site
700598013993	motif 2; other site
700598013994	motif 3; other site
700598013995	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
700598013996	anticodon binding site; other site
700598013997	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
700598013998	homodimer interface [polypeptide binding]; other site
700598013999	metal binding site [ion binding]; metal-binding site
700598014000	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
700598014001	putative active site [active]
700598014002	dimerization interface [polypeptide binding]; other site
700598014003	putative tRNAtyr binding site [nucleotide binding]; other site
700598014004	hypothetical protein; Provisional; Region: PRK09256
700598014005	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
700598014006	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
700598014007	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
700598014008	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
700598014009	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
700598014010	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
700598014011	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
700598014012	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
700598014013	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
700598014014	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
700598014015	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
700598014016	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598014017	FeS/SAM binding site; other site
700598014018	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700598014019	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
700598014020	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598014021	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
700598014022	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
700598014023	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700598014024	inhibitor-cofactor binding pocket; inhibition site
700598014025	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598014026	catalytic residue [active]
700598014027	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
700598014028	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
700598014029	trimer interface [polypeptide binding]; other site
700598014030	putative metal binding site [ion binding]; other site
700598014031	GTPase RsgA; Reviewed; Region: PRK00098
700598014032	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
700598014033	RNA binding site [nucleotide binding]; other site
700598014034	homodimer interface [polypeptide binding]; other site
700598014035	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
700598014036	GTPase/Zn-binding domain interface [polypeptide binding]; other site
700598014037	GTP/Mg2+ binding site [chemical binding]; other site
700598014038	G4 box; other site
700598014039	G5 box; other site
700598014040	G1 box; other site
700598014041	Switch I region; other site
700598014042	G2 box; other site
700598014043	G3 box; other site
700598014044	Switch II region; other site
700598014045	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
700598014046	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
700598014047	metal ion-dependent adhesion site (MIDAS); other site
700598014048	Oxygen tolerance; Region: BatD; pfam13584
700598014049	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
700598014050	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
700598014051	metal ion-dependent adhesion site (MIDAS); other site
700598014052	MoxR-like ATPases [General function prediction only]; Region: COG0714
700598014053	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598014054	Walker A motif; other site
700598014055	ATP binding site [chemical binding]; other site
700598014056	Walker B motif; other site
700598014057	arginine finger; other site
700598014058	NAD synthetase; Provisional; Region: PRK13981
700598014059	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
700598014060	multimer interface [polypeptide binding]; other site
700598014061	active site
700598014062	catalytic triad [active]
700598014063	protein interface 1 [polypeptide binding]; other site
700598014064	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
700598014065	homodimer interface [polypeptide binding]; other site
700598014066	NAD binding pocket [chemical binding]; other site
700598014067	ATP binding pocket [chemical binding]; other site
700598014068	Mg binding site [ion binding]; other site
700598014069	active-site loop [active]
700598014070	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
700598014071	YcxB-like protein; Region: YcxB; pfam14317
700598014072	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
700598014073	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
700598014074	active site
700598014075	dimer interface [polypeptide binding]; other site
700598014076	effector binding site; other site
700598014077	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
700598014078	TSCPD domain; Region: TSCPD; pfam12637
700598014079	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
700598014080	geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169
700598014081	PcrB family; Region: PcrB; pfam01884
700598014082	phosphate binding site [ion binding]; other site
700598014083	argininosuccinate synthase; Provisional; Region: PRK13820
700598014084	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
700598014085	Ligand Binding Site [chemical binding]; other site
700598014086	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
700598014087	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700598014088	inhibitor-cofactor binding pocket; inhibition site
700598014089	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598014090	catalytic residue [active]
700598014091	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
700598014092	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
700598014093	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
700598014094	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
700598014095	nucleotide binding site [chemical binding]; other site
700598014096	N-acetyl-L-glutamate binding site [chemical binding]; other site
700598014097	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
700598014098	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651
700598014099	metal binding site [ion binding]; metal-binding site
700598014100	dimer interface [polypeptide binding]; other site
700598014101	argininosuccinate lyase; Provisional; Region: PRK00855
700598014102	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
700598014103	active sites [active]
700598014104	tetramer interface [polypeptide binding]; other site
700598014105	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700598014106	M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021
700598014107	Peptidase family M28; Region: Peptidase_M28; pfam04389
700598014108	metal binding site [ion binding]; metal-binding site
700598014109	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
700598014110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014111	active site
700598014112	phosphorylation site [posttranslational modification]
700598014113	intermolecular recognition site; other site
700598014114	dimerization interface [polypeptide binding]; other site
700598014115	LytTr DNA-binding domain; Region: LytTR; smart00850
700598014116	Histidine kinase; Region: His_kinase; pfam06580
700598014117	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
700598014118	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
700598014119	TPP-binding site; other site
700598014120	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700598014121	PYR/PP interface [polypeptide binding]; other site
700598014122	dimer interface [polypeptide binding]; other site
700598014123	TPP binding site [chemical binding]; other site
700598014124	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700598014125	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
700598014126	ScpA/B protein; Region: ScpA_ScpB; cl00598
700598014127	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
700598014128	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
700598014129	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
700598014130	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
700598014131	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
700598014132	EamA-like transporter family; Region: EamA; pfam00892
700598014133	ribosome recycling factor; Reviewed; Region: frr; PRK00083
700598014134	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
700598014135	hinge region; other site
700598014136	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
700598014137	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
700598014138	Mg++ binding site [ion binding]; other site
700598014139	putative catalytic motif [active]
700598014140	substrate binding site [chemical binding]; other site
700598014141	transketolase; Reviewed; Region: PRK05899
700598014142	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
700598014143	TPP-binding site [chemical binding]; other site
700598014144	dimer interface [polypeptide binding]; other site
700598014145	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
700598014146	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598014147	FtsX-like permease family; Region: FtsX; pfam02687
700598014148	Ribosome-binding factor A; Region: RBFA; pfam02033
700598014149	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700598014150	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598014151	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
700598014152	Walker A/P-loop; other site
700598014153	ATP binding site [chemical binding]; other site
700598014154	Q-loop/lid; other site
700598014155	ABC transporter signature motif; other site
700598014156	Walker B; other site
700598014157	D-loop; other site
700598014158	H-loop/switch region; other site
700598014159	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
700598014160	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598014161	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
700598014162	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
700598014163	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598014164	active site
700598014165	HIGH motif; other site
700598014166	nucleotide binding site [chemical binding]; other site
700598014167	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598014168	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
700598014169	active site
700598014170	KMSKS motif; other site
700598014171	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
700598014172	tRNA binding surface [nucleotide binding]; other site
700598014173	anticodon binding site; other site
700598014174	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
700598014175	ferrochelatase; Reviewed; Region: hemH; PRK00035
700598014176	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
700598014177	C-terminal domain interface [polypeptide binding]; other site
700598014178	active site
700598014179	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
700598014180	active site
700598014181	N-terminal domain interface [polypeptide binding]; other site
700598014182	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
700598014183	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
700598014184	tRNA; other site
700598014185	putative tRNA binding site [nucleotide binding]; other site
700598014186	putative NADP binding site [chemical binding]; other site
700598014187	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
700598014188	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
700598014189	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
700598014190	domain interfaces; other site
700598014191	active site
700598014192	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
700598014193	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
700598014194	active site
700598014195	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
700598014196	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
700598014197	substrate binding site [chemical binding]; other site
700598014198	active site
700598014199	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
700598014200	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
700598014201	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
700598014202	dimer interface [polypeptide binding]; other site
700598014203	allosteric magnesium binding site [ion binding]; other site
700598014204	active site
700598014205	aspartate-rich active site metal binding site; other site
700598014206	Schiff base residues; other site
700598014207	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
700598014208	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700598014209	inhibitor-cofactor binding pocket; inhibition site
700598014210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598014211	catalytic residue [active]
700598014212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
700598014213	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
700598014214	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
700598014215	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
700598014216	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
700598014217	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598014218	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598014219	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
700598014220	Peptidase family M23; Region: Peptidase_M23; pfam01551
700598014221	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
700598014222	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
700598014223	motif 1; other site
700598014224	active site
700598014225	motif 2; other site
700598014226	motif 3; other site
700598014227	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
700598014228	DHHA1 domain; Region: DHHA1; pfam02272
700598014229	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700598014230	Peptidase family M28; Region: Peptidase_M28; pfam04389
700598014231	metal binding site [ion binding]; metal-binding site
700598014232	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700598014233	protein binding site [polypeptide binding]; other site
700598014234	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700598014235	protein binding site [polypeptide binding]; other site
700598014236	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
700598014237	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
700598014238	GatB domain; Region: GatB_Yqey; smart00845
700598014239	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
700598014240	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598014241	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598014242	catalytic residues [active]
700598014243	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598014244	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598014245	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598014246	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598014247	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598014248	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598014249	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
700598014250	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598014251	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598014252	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598014253	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598014254	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598014255	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
700598014256	Protein export membrane protein; Region: SecD_SecF; cl14618
700598014257	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
700598014258	Recombination protein O N terminal; Region: RecO_N; pfam11967
700598014259	Recombination protein O C terminal; Region: RecO_C; pfam02565
700598014260	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598014261	Amidohydrolase; Region: Amidohydro_4; pfam13147
700598014262	active site
700598014263	peptide chain release factor 1; Validated; Region: prfA; PRK00591
700598014264	This domain is found in peptide chain release factors; Region: PCRF; smart00937
700598014265	RF-1 domain; Region: RF-1; pfam00472
700598014266	putative anti-sigmaE protein; Provisional; Region: PRK13920
700598014267	Anti-sigma-K factor rskA; Region: RskA; pfam10099
700598014268	RNA polymerase sigma factor; Provisional; Region: PRK12519
700598014269	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598014270	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598014271	DNA binding residues [nucleotide binding]
700598014272	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
700598014273	lipoyl attachment site [posttranslational modification]; other site
700598014274	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
700598014275	active site
700598014276	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598014277	Coenzyme A binding pocket [chemical binding]; other site
700598014278	seryl-tRNA synthetase; Provisional; Region: PRK05431
700598014279	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
700598014280	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
700598014281	dimer interface [polypeptide binding]; other site
700598014282	active site
700598014283	motif 1; other site
700598014284	motif 2; other site
700598014285	motif 3; other site
700598014286	Autotransporter beta-domain; Region: Autotransporter; cl17461
700598014287	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
700598014288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
700598014289	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
700598014290	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598014291	ATP binding site [chemical binding]; other site
700598014292	Mg2+ binding site [ion binding]; other site
700598014293	G-X-G motif; other site
700598014294	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
700598014295	anchoring element; other site
700598014296	dimer interface [polypeptide binding]; other site
700598014297	ATP binding site [chemical binding]; other site
700598014298	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
700598014299	active site
700598014300	putative metal-binding site [ion binding]; other site
700598014301	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
700598014302	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
700598014303	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700598014304	DNA binding residues [nucleotide binding]
700598014305	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
700598014306	Mechanosensitive ion channel; Region: MS_channel; pfam00924
700598014307	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598014308	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
700598014309	putative active site [active]
700598014310	putative metal binding site [ion binding]; other site
700598014311	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
700598014312	putative active site pocket [active]
700598014313	dimerization interface [polypeptide binding]; other site
700598014314	putative catalytic residue [active]
700598014315	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
700598014316	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
700598014317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598014318	Walker A motif; other site
700598014319	ATP binding site [chemical binding]; other site
700598014320	Walker B motif; other site
700598014321	arginine finger; other site
700598014322	Peptidase family M41; Region: Peptidase_M41; pfam01434
700598014323	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
700598014324	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
700598014325	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
700598014326	YceI-like domain; Region: YceI; pfam04264
700598014327	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
700598014328	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700598014329	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700598014330	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
700598014331	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598014332	catalytic triad [active]
700598014333	Peptidase family M23; Region: Peptidase_M23; pfam01551
700598014334	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
700598014335	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700598014336	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
700598014337	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700598014338	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
700598014339	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
700598014340	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700598014341	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
700598014342	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700598014343	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598014344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014345	active site
700598014346	phosphorylation site [posttranslational modification]
700598014347	intermolecular recognition site; other site
700598014348	dimerization interface [polypeptide binding]; other site
700598014349	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598014350	DNA binding residues [nucleotide binding]
700598014351	dimerization interface [polypeptide binding]; other site
700598014352	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598014353	Histidine kinase; Region: HisKA_3; pfam07730
700598014354	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598014355	ATP binding site [chemical binding]; other site
700598014356	Mg2+ binding site [ion binding]; other site
700598014357	G-X-G motif; other site
700598014358	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
700598014359	Competence protein; Region: Competence; pfam03772
700598014360	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
700598014361	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
700598014362	purine monophosphate binding site [chemical binding]; other site
700598014363	dimer interface [polypeptide binding]; other site
700598014364	putative catalytic residues [active]
700598014365	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
700598014366	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
700598014367	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931
700598014368	putative active site [active]
700598014369	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
700598014370	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
700598014371	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
700598014372	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
700598014373	gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512
700598014374	gliding motility-associated protein GldE; Region: GldE; TIGR03520
700598014375	Domain of unknown function DUF21; Region: DUF21; pfam01595
700598014376	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
700598014377	Transporter associated domain; Region: CorC_HlyC; smart01091
700598014378	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
700598014379	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
700598014380	dimer interface [polypeptide binding]; other site
700598014381	ssDNA binding site [nucleotide binding]; other site
700598014382	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700598014383	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
700598014384	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700598014385	minor groove reading motif; other site
700598014386	helix-hairpin-helix signature motif; other site
700598014387	substrate binding pocket [chemical binding]; other site
700598014388	active site
700598014389	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
700598014390	DNA binding and oxoG recognition site [nucleotide binding]
700598014391	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
700598014392	IHF - DNA interface [nucleotide binding]; other site
700598014393	IHF dimer interface [polypeptide binding]; other site
700598014394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598014395	binding surface
700598014396	TPR motif; other site
700598014397	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
700598014398	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
700598014399	homodimer interface [polypeptide binding]; other site
700598014400	oligonucleotide binding site [chemical binding]; other site
700598014401	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
700598014402	DNA repair protein RadA; Provisional; Region: PRK11823
700598014403	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
700598014404	Walker A motif/ATP binding site; other site
700598014405	ATP binding site [chemical binding]; other site
700598014406	Walker B motif; other site
700598014407	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
700598014408	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
700598014409	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700598014410	active site
700598014411	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
700598014412	catalytic residues [active]
700598014413	dimer interface [polypeptide binding]; other site
700598014414	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
700598014415	DNA polymerase III subunit delta'; Validated; Region: PRK08485
700598014416	DNA polymerase III subunit delta'; Validated; Region: PRK08058
700598014417	PSP1 C-terminal conserved region; Region: PSP1; cl00770
700598014418	Bax inhibitor 1 like; Region: BaxI_1; cl17691
700598014419	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
700598014420	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
700598014421	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
700598014422	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
700598014423	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
700598014424	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
700598014425	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
700598014426	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
700598014427	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598014428	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598014429	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598014430	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
700598014431	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598014432	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598014433	Protein of unknown function (DUF502); Region: DUF502; cl01107
700598014434	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981
700598014435	Zn binding site [ion binding]; other site
700598014436	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
700598014437	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598014438	catalytic residue [active]
700598014439	Uncharacterized conserved protein [Function unknown]; Region: COG4198
700598014440	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
700598014441	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598014442	TPR motif; other site
700598014443	binding surface
700598014444	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598014445	Tetratricopeptide repeat; Region: TPR_16; pfam13432
700598014446	TPR motif; other site
700598014447	binding surface
700598014448	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
700598014449	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
700598014450	acyl-activating enzyme (AAE) consensus motif; other site
700598014451	putative AMP binding site [chemical binding]; other site
700598014452	putative active site [active]
700598014453	putative CoA binding site [chemical binding]; other site
700598014454	tyrosine decarboxylase; Region: PLN02880
700598014455	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700598014456	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598014457	catalytic residue [active]
700598014458	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
700598014459	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
700598014460	homodimer interface [polypeptide binding]; other site
700598014461	substrate-cofactor binding pocket; other site
700598014462	catalytic residue [active]
700598014463	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700598014464	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598014465	NAD(P) binding site [chemical binding]; other site
700598014466	active site
700598014467	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
700598014468	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598014469	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598014470	dimerization interface [polypeptide binding]; other site
700598014471	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598014472	dimer interface [polypeptide binding]; other site
700598014473	phosphorylation site [posttranslational modification]
700598014474	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598014475	ATP binding site [chemical binding]; other site
700598014476	Mg2+ binding site [ion binding]; other site
700598014477	G-X-G motif; other site
700598014478	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598014479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014480	active site
700598014481	phosphorylation site [posttranslational modification]
700598014482	intermolecular recognition site; other site
700598014483	dimerization interface [polypeptide binding]; other site
700598014484	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598014485	DNA binding site [nucleotide binding]
700598014486	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
700598014487	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
700598014488	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
700598014489	Response regulator receiver domain; Region: Response_reg; pfam00072
700598014490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014491	active site
700598014492	phosphorylation site [posttranslational modification]
700598014493	intermolecular recognition site; other site
700598014494	dimerization interface [polypeptide binding]; other site
700598014495	Response regulator receiver domain; Region: Response_reg; pfam00072
700598014496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014497	active site
700598014498	phosphorylation site [posttranslational modification]
700598014499	intermolecular recognition site; other site
700598014500	dimerization interface [polypeptide binding]; other site
700598014501	CHASE3 domain; Region: CHASE3; pfam05227
700598014502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598014503	phosphorylation site [posttranslational modification]
700598014504	dimer interface [polypeptide binding]; other site
700598014505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598014506	ATP binding site [chemical binding]; other site
700598014507	Mg2+ binding site [ion binding]; other site
700598014508	G-X-G motif; other site
700598014509	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
700598014510	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
700598014511	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
700598014512	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
700598014513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014514	active site
700598014515	phosphorylation site [posttranslational modification]
700598014516	intermolecular recognition site; other site
700598014517	dimerization interface [polypeptide binding]; other site
700598014518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598014519	Walker A motif; other site
700598014520	ATP binding site [chemical binding]; other site
700598014521	Walker B motif; other site
700598014522	arginine finger; other site
700598014523	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598014524	PAS domain; Region: PAS_9; pfam13426
700598014525	putative active site [active]
700598014526	heme pocket [chemical binding]; other site
700598014527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598014528	dimer interface [polypeptide binding]; other site
700598014529	phosphorylation site [posttranslational modification]
700598014530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598014531	ATP binding site [chemical binding]; other site
700598014532	Mg2+ binding site [ion binding]; other site
700598014533	G-X-G motif; other site
700598014534	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598014535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014536	active site
700598014537	phosphorylation site [posttranslational modification]
700598014538	intermolecular recognition site; other site
700598014539	dimerization interface [polypeptide binding]; other site
700598014540	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598014541	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
700598014542	putative active site [active]
700598014543	heme pocket [chemical binding]; other site
700598014544	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598014545	dimer interface [polypeptide binding]; other site
700598014546	phosphorylation site [posttranslational modification]
700598014547	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598014548	ATP binding site [chemical binding]; other site
700598014549	Mg2+ binding site [ion binding]; other site
700598014550	G-X-G motif; other site
700598014551	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598014552	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
700598014553	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598014554	Family of unknown function (DUF490); Region: DUF490; pfam04357
700598014555	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
700598014556	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
700598014557	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
700598014558	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598014559	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598014560	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
700598014561	ligand binding site [chemical binding]; other site
700598014562	flexible hinge region; other site
700598014563	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
700598014564	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
700598014565	active site
700598014566	DNA binding site [nucleotide binding]
700598014567	Int/Topo IB signature motif; other site
700598014568	catalytic residues [active]
700598014569	Low affinity iron permease; Region: Iron_permease; pfam04120
700598014570	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
700598014571	dimerization interface [polypeptide binding]; other site
700598014572	metal binding site [ion binding]; metal-binding site
700598014573	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598014574	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598014575	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
700598014576	Family description; Region: VCBS; pfam13517
700598014577	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
700598014578	FG-GAP repeat; Region: FG-GAP; cl15299
700598014579	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
700598014580	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598014581	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
700598014582	anthranilate synthase component I; Provisional; Region: PRK13569
700598014583	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598014584	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598014585	ligand binding site [chemical binding]; other site
700598014586	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
700598014587	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
700598014588	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598014589	Walker A/P-loop; other site
700598014590	ATP binding site [chemical binding]; other site
700598014591	Q-loop/lid; other site
700598014592	ABC transporter signature motif; other site
700598014593	Walker B; other site
700598014594	D-loop; other site
700598014595	H-loop/switch region; other site
700598014596	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
700598014597	Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928
700598014598	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
700598014599	active site
700598014600	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598014601	catalytic loop [active]
700598014602	iron binding site [ion binding]; other site
700598014603	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
700598014604	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598014605	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
700598014606	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
700598014607	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598014608	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700598014609	Domain of unknown function (DUF2341); Region: DUF2341; pfam10102
700598014610	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
700598014611	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598014612	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598014613	NAD(P) binding site [chemical binding]; other site
700598014614	active site
700598014615	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
700598014616	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700598014617	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
700598014618	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
700598014619	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
700598014620	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
700598014621	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
700598014622	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295
700598014623	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
700598014624	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
700598014625	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
700598014626	active site
700598014627	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
700598014628	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598014629	active site
700598014630	HIGH motif; other site
700598014631	nucleotide binding site [chemical binding]; other site
700598014632	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
700598014633	nudix motif; other site
700598014634	Ycf48-like protein; Provisional; Region: PRK13684
700598014635	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
700598014636	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
700598014637	nudix motif; other site
700598014638	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
700598014639	Methyltransferase domain; Region: Methyltransf_12; pfam08242
700598014640	HEAT repeats; Region: HEAT_2; pfam13646
700598014641	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
700598014642	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
700598014643	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
700598014644	metal ion-dependent adhesion site (MIDAS); other site
700598014645	MoxR-like ATPases [General function prediction only]; Region: COG0714
700598014646	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598014647	Walker A motif; other site
700598014648	ATP binding site [chemical binding]; other site
700598014649	Walker B motif; other site
700598014650	arginine finger; other site
700598014651	SWIM zinc finger; Region: SWIM; pfam04434
700598014652	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700598014653	binding surface
700598014654	TPR motif; other site
700598014655	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598014656	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700598014657	Walker A motif; other site
700598014658	ATP binding site [chemical binding]; other site
700598014659	Walker B motif; other site
700598014660	arginine finger; other site
700598014661	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
700598014662	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
700598014663	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
700598014664	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
700598014665	dimerization interface [polypeptide binding]; other site
700598014666	DPS ferroxidase diiron center [ion binding]; other site
700598014667	ion pore; other site
700598014668	Pirin-related protein [General function prediction only]; Region: COG1741
700598014669	Pirin; Region: Pirin; pfam02678
700598014670	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
700598014671	DinB superfamily; Region: DinB_2; pfam12867
700598014672	Phosphopantetheine attachment site; Region: PP-binding; cl09936
700598014673	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
700598014674	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
700598014675	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
700598014676	putative ligand binding site [chemical binding]; other site
700598014677	transaminase; Validated; Region: PRK07324
700598014678	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598014679	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598014680	homodimer interface [polypeptide binding]; other site
700598014681	catalytic residue [active]
700598014682	metal-dependent hydrolase; Provisional; Region: PRK13291
700598014683	DinB superfamily; Region: DinB_2; pfam12867
700598014684	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
700598014685	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598014686	dimer interface [polypeptide binding]; other site
700598014687	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
700598014688	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
700598014689	conserved cys residue [active]
700598014690	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598014691	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598014692	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598014693	dimerization interface [polypeptide binding]; other site
700598014694	putative DNA binding site [nucleotide binding]; other site
700598014695	putative Zn2+ binding site [ion binding]; other site
700598014696	SWIB/MDM2 domain; Region: SWIB; pfam02201
700598014697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
700598014698	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
700598014699	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700598014700	Cation transporter family protein; Region: LIC; TIGR00860
700598014701	Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931
700598014702	Transposase; Region: DEDD_Tnp_IS110; pfam01548
700598014703	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
700598014704	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
700598014705	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
700598014706	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598014707	nucleophilic elbow; other site
700598014708	catalytic triad; other site
700598014709	putative pectinesterase; Region: PLN02432; cl01911
700598014710	Pectinesterase; Region: Pectinesterase; pfam01095
700598014711	Response regulator receiver domain; Region: Response_reg; pfam00072
700598014712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014713	active site
700598014714	phosphorylation site [posttranslational modification]
700598014715	intermolecular recognition site; other site
700598014716	dimerization interface [polypeptide binding]; other site
700598014717	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598014718	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700598014719	Coenzyme A binding pocket [chemical binding]; other site
700598014720	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
700598014721	carboxyltransferase (CT) interaction site; other site
700598014722	biotinylation site [posttranslational modification]; other site
700598014723	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
700598014724	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700598014725	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
700598014726	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
700598014727	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
700598014728	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
700598014729	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
700598014730	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700598014731	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598014732	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
700598014733	WYL domain; Region: WYL; pfam13280
700598014734	Prokaryotic RING finger family 4; Region: Prok-RING_4; pfam14447
700598014735	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565
700598014736	putative metal binding site [ion binding]; other site
700598014737	Peptidase S24-like; Region: Peptidase_S24; pfam00717
700598014738	Catalytic site [active]
700598014739	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
700598014740	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
700598014741	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
700598014742	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
700598014743	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
700598014744	active site
700598014745	catalytic triad [active]
700598014746	oxyanion hole [active]
700598014747	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
700598014748	putative active site [active]
700598014749	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
700598014750	putative catalytic site [active]
700598014751	putative metal binding site [ion binding]; other site
700598014752	putative phosphate binding site [ion binding]; other site
700598014753	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
700598014754	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
700598014755	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598014756	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598014757	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598014758	SusD family; Region: SusD; pfam07980
700598014759	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598014760	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598014761	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598014762	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
700598014763	FecR protein; Region: FecR; pfam04773
700598014764	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598014765	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598014766	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598014767	DNA binding residues [nucleotide binding]
700598014768	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
700598014769	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598014770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598014771	putative substrate translocation pore; other site
700598014772	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598014773	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598014774	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598014775	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
700598014776	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
700598014777	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598014778	Active site serine [active]
700598014779	oxidoreductase; Provisional; Region: PRK06196
700598014780	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
700598014781	putative NAD(P) binding site [chemical binding]; other site
700598014782	active site
700598014783	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598014784	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316
700598014785	NADP binding site [chemical binding]; other site
700598014786	active site
700598014787	steroid binding site; other site
700598014788	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598014789	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598014790	ligand binding site [chemical binding]; other site
700598014791	flexible hinge region; other site
700598014792	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
700598014793	YARHG domain; Region: YARHG; pfam13308
700598014794	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
700598014795	Histidine kinase; Region: His_kinase; pfam06580
700598014796	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598014797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014798	active site
700598014799	phosphorylation site [posttranslational modification]
700598014800	intermolecular recognition site; other site
700598014801	dimerization interface [polypeptide binding]; other site
700598014802	LytTr DNA-binding domain; Region: LytTR; smart00850
700598014803	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
700598014804	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598014805	ligand binding site [chemical binding]; other site
700598014806	flexible hinge region; other site
700598014807	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700598014808	putative switch regulator; other site
700598014809	non-specific DNA interactions [nucleotide binding]; other site
700598014810	DNA binding site [nucleotide binding]
700598014811	sequence specific DNA binding site [nucleotide binding]; other site
700598014812	putative cAMP binding site [chemical binding]; other site
700598014813	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
700598014814	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
700598014815	Cl- selectivity filter; other site
700598014816	Cl- binding residues [ion binding]; other site
700598014817	pore gating glutamate residue; other site
700598014818	dimer interface [polypeptide binding]; other site
700598014819	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
700598014820	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
700598014821	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
700598014822	SnoaL-like domain; Region: SnoaL_2; pfam12680
700598014823	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
700598014824	heme binding pocket [chemical binding]; other site
700598014825	heme ligand [chemical binding]; other site
700598014826	Response regulator receiver domain; Region: Response_reg; pfam00072
700598014827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014828	active site
700598014829	phosphorylation site [posttranslational modification]
700598014830	intermolecular recognition site; other site
700598014831	dimerization interface [polypeptide binding]; other site
700598014832	CheB methylesterase; Region: CheB_methylest; pfam01339
700598014833	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
700598014834	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
700598014835	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
700598014836	PAS domain; Region: PAS_10; pfam13596
700598014837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598014838	PAS fold; Region: PAS_3; pfam08447
700598014839	putative active site [active]
700598014840	heme pocket [chemical binding]; other site
700598014841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598014842	PAS fold; Region: PAS_3; pfam08447
700598014843	putative active site [active]
700598014844	heme pocket [chemical binding]; other site
700598014845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598014846	dimer interface [polypeptide binding]; other site
700598014847	phosphorylation site [posttranslational modification]
700598014848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598014849	ATP binding site [chemical binding]; other site
700598014850	Mg2+ binding site [ion binding]; other site
700598014851	G-X-G motif; other site
700598014852	PAS fold; Region: PAS_2; pfam08446
700598014853	GAF domain; Region: GAF; pfam01590
700598014854	Phytochrome region; Region: PHY; pfam00360
700598014855	hydroxyglutarate oxidase; Provisional; Region: PRK11728
700598014856	hypothetical protein; Provisional; Region: PRK06834
700598014857	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700598014858	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598014859	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598014860	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
700598014861	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
700598014862	tetramer interface [polypeptide binding]; other site
700598014863	active site
700598014864	Mg2+/Mn2+ binding site [ion binding]; other site
700598014865	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
700598014866	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
700598014867	conserved cys residue [active]
700598014868	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598014869	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598014870	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598014871	hydrophobic ligand binding site; other site
700598014872	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598014873	NAD(P) binding site [chemical binding]; other site
700598014874	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
700598014875	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598014876	active site
700598014877	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
700598014878	Leucine-rich repeats; other site
700598014879	Substrate binding site [chemical binding]; other site
700598014880	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
700598014881	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
700598014882	hydrophobic ligand binding site; other site
700598014883	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598014884	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
700598014885	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
700598014886	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
700598014887	Helix-turn-helix domain; Region: HTH_17; pfam12728
700598014888	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
700598014889	Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461
700598014890	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
700598014891	ATP binding site [chemical binding]; other site
700598014892	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
700598014893	active site
700598014894	NTP binding site [chemical binding]; other site
700598014895	metal binding triad [ion binding]; metal-binding site
700598014896	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
700598014897	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
700598014898	Int/Topo IB signature motif; other site
700598014899	DinB family; Region: DinB; cl17821
700598014900	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598014901	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
700598014902	dimer interface [polypeptide binding]; other site
700598014903	putative metal binding site [ion binding]; other site
700598014904	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598014905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598014906	ATP binding site [chemical binding]; other site
700598014907	Mg2+ binding site [ion binding]; other site
700598014908	G-X-G motif; other site
700598014909	Response regulator receiver domain; Region: Response_reg; pfam00072
700598014910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014911	active site
700598014912	phosphorylation site [posttranslational modification]
700598014913	intermolecular recognition site; other site
700598014914	dimerization interface [polypeptide binding]; other site
700598014915	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
700598014916	putative binding surface; other site
700598014917	active site
700598014918	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
700598014919	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598014920	active site
700598014921	phosphorylation site [posttranslational modification]
700598014922	intermolecular recognition site; other site
700598014923	dimerization interface [polypeptide binding]; other site
700598014924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598014925	Walker A motif; other site
700598014926	ATP binding site [chemical binding]; other site
700598014927	Walker B motif; other site
700598014928	arginine finger; other site
700598014929	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
700598014930	Part of AAA domain; Region: AAA_19; pfam13245
700598014931	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
700598014932	Bacterial Ig-like domain; Region: Big_5; pfam13205
700598014933	recombination protein RecR; Reviewed; Region: recR; PRK00076
700598014934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598014935	ATP binding site [chemical binding]; other site
700598014936	Walker A/P-loop; other site
700598014937	RecR protein; Region: RecR; pfam02132
700598014938	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
700598014939	putative active site [active]
700598014940	putative metal-binding site [ion binding]; other site
700598014941	tetramer interface [polypeptide binding]; other site
700598014942	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
700598014943	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
700598014944	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
700598014945	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
700598014946	substrate binding pocket [chemical binding]; other site
700598014947	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
700598014948	B12 binding site [chemical binding]; other site
700598014949	cobalt ligand [ion binding]; other site
700598014950	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
700598014951	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
700598014952	Escherichia coli exonuclease III (ExoIII)-like apurinic/apyrimidinic (AP) endonucleases; Region: ExoIII_AP-endo; cd09073
700598014953	active site
700598014954	putative catalytic site [active]
700598014955	DNA binding site [nucleotide binding]
700598014956	putative phosphate binding site [ion binding]; other site
700598014957	metal binding site A [ion binding]; metal-binding site
700598014958	AP binding site [nucleotide binding]; other site
700598014959	putative metal binding site B [ion binding]; other site
700598014960	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
700598014961	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
700598014962	IHF - DNA interface [nucleotide binding]; other site
700598014963	IHF dimer interface [polypeptide binding]; other site
700598014964	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
700598014965	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
700598014966	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
700598014967	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
700598014968	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
700598014969	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
700598014970	putative nucleotide binding site [chemical binding]; other site
700598014971	uridine monophosphate binding site [chemical binding]; other site
700598014972	homohexameric interface [polypeptide binding]; other site
700598014973	elongation factor Ts; Provisional; Region: tsf; PRK09377
700598014974	UBA/TS-N domain; Region: UBA; pfam00627
700598014975	Elongation factor TS; Region: EF_TS; pfam00889
700598014976	Elongation factor TS; Region: EF_TS; pfam00889
700598014977	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
700598014978	rRNA interaction site [nucleotide binding]; other site
700598014979	S8 interaction site; other site
700598014980	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
700598014981	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
700598014982	23S rRNA interface [nucleotide binding]; other site
700598014983	L3 interface [polypeptide binding]; other site
700598014984	von Willebrand factor; Region: vWF_A; pfam12450
700598014985	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
700598014986	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
700598014987	metal ion-dependent adhesion site (MIDAS); other site
700598014988	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
700598014989	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
700598014990	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
700598014991	putative active site [active]
700598014992	putative NTP binding site [chemical binding]; other site
700598014993	putative nucleic acid binding site [nucleotide binding]; other site
700598014994	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
700598014995	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
700598014996	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
700598014997	putative active site [active]
700598014998	putative NTP binding site [chemical binding]; other site
700598014999	putative nucleic acid binding site [nucleotide binding]; other site
700598015000	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
700598015001	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
700598015002	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
700598015003	Family description; Region: VCBS; pfam13517
700598015004	Family description; Region: VCBS; pfam13517
700598015005	Family description; Region: VCBS; pfam13517
700598015006	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
700598015007	Family description; Region: VCBS; pfam13517
700598015008	Family description; Region: VCBS; pfam13517
700598015009	Family description; Region: VCBS; pfam13517
700598015010	Family description; Region: VCBS; pfam13517
700598015011	Family description; Region: VCBS; pfam13517
700598015012	Family description; Region: VCBS; pfam13517
700598015013	Family description; Region: VCBS; pfam13517
700598015014	Family description; Region: VCBS; pfam13517
700598015015	Family description; Region: VCBS; pfam13517
700598015016	Family description; Region: VCBS; pfam13517
700598015017	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
700598015018	Family description; Region: VCBS; pfam13517
700598015019	Family description; Region: VCBS; pfam13517
700598015020	Family description; Region: VCBS; pfam13517
700598015021	Family description; Region: VCBS; pfam13517
700598015022	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598015023	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598015024	SusD family; Region: SusD; pfam07980
700598015025	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598015026	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598015027	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598015028	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598015029	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
700598015030	nudix motif; other site
700598015031	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
700598015032	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
700598015033	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
700598015034	nucleotide binding pocket [chemical binding]; other site
700598015035	K-X-D-G motif; other site
700598015036	catalytic site [active]
700598015037	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
700598015038	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
700598015039	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
700598015040	Dimer interface [polypeptide binding]; other site
700598015041	HNH endonuclease; Region: HNH_3; pfam13392
700598015042	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
700598015043	DNA-binding interface [nucleotide binding]; DNA binding site
700598015044	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
700598015045	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
700598015046	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
700598015047	Lamin Tail Domain; Region: LTD; pfam00932
700598015048	Lamin Tail Domain; Region: LTD; pfam00932
700598015049	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
700598015050	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
700598015051	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700598015052	substrate binding site [chemical binding]; other site
700598015053	ATP binding site [chemical binding]; other site
700598015054	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598015055	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598015056	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
700598015057	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
700598015058	FAD binding pocket [chemical binding]; other site
700598015059	FAD binding motif [chemical binding]; other site
700598015060	phosphate binding motif [ion binding]; other site
700598015061	beta-alpha-beta structure motif; other site
700598015062	NAD(p) ribose binding residues [chemical binding]; other site
700598015063	NAD binding pocket [chemical binding]; other site
700598015064	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
700598015065	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598015066	catalytic loop [active]
700598015067	iron binding site [ion binding]; other site
700598015068	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
700598015069	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
700598015070	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
700598015071	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598015072	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
700598015073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
700598015074	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
700598015075	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
700598015076	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
700598015077	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
700598015078	WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998
700598015079	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
700598015080	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
700598015081	putative active site [active]
700598015082	putative NTP binding site [chemical binding]; other site
700598015083	putative nucleic acid binding site [nucleotide binding]; other site
700598015084	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700598015085	endonuclease III; Region: ENDO3c; smart00478
700598015086	minor groove reading motif; other site
700598015087	helix-hairpin-helix signature motif; other site
700598015088	substrate binding pocket [chemical binding]; other site
700598015089	active site
700598015090	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
700598015091	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
700598015092	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598015093	active site
700598015094	HIGH motif; other site
700598015095	nucleotide binding site [chemical binding]; other site
700598015096	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
700598015097	KMSKS motif; other site
700598015098	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
700598015099	tRNA binding surface [nucleotide binding]; other site
700598015100	anticodon binding site; other site
700598015101	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
700598015102	putative catalytic site [active]
700598015103	putative metal binding site [ion binding]; other site
700598015104	putative phosphate binding site [ion binding]; other site
700598015105	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
700598015106	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
700598015107	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
700598015108	TRAM domain; Region: TRAM; cl01282
700598015109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598015110	S-adenosylmethionine binding site [chemical binding]; other site
700598015111	methionine sulfoxide reductase B; Provisional; Region: PRK00222
700598015112	SelR domain; Region: SelR; pfam01641
700598015113	adenylate kinase; Reviewed; Region: adk; PRK00279
700598015114	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
700598015115	AMP-binding site [chemical binding]; other site
700598015116	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
700598015117	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700598015118	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700598015119	protein binding site [polypeptide binding]; other site
700598015120	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
700598015121	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
700598015122	substrate binding site [chemical binding]; other site
700598015123	dimer interface [polypeptide binding]; other site
700598015124	NADP binding site [chemical binding]; other site
700598015125	catalytic residues [active]
700598015126	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700598015127	active site 2 [active]
700598015128	active site 1 [active]
700598015129	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700598015130	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
700598015131	substrate binding site [chemical binding]; other site
700598015132	oxyanion hole (OAH) forming residues; other site
700598015133	trimer interface [polypeptide binding]; other site
700598015134	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700598015135	endonuclease III; Region: ENDO3c; smart00478
700598015136	minor groove reading motif; other site
700598015137	helix-hairpin-helix signature motif; other site
700598015138	substrate binding pocket [chemical binding]; other site
700598015139	active site
700598015140	NHAD transporter family protein; Provisional; Region: PLN00137
700598015141	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
700598015142	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
700598015143	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
700598015144	NAD(P) binding site [chemical binding]; other site
700598015145	homotetramer interface [polypeptide binding]; other site
700598015146	homodimer interface [polypeptide binding]; other site
700598015147	active site
700598015148	GH3 auxin-responsive promoter; Region: GH3; pfam03321
700598015149	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
700598015150	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
700598015151	Walker A/P-loop; other site
700598015152	ATP binding site [chemical binding]; other site
700598015153	Q-loop/lid; other site
700598015154	ABC transporter signature motif; other site
700598015155	Walker B; other site
700598015156	D-loop; other site
700598015157	H-loop/switch region; other site
700598015158	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
700598015159	FAD binding site [chemical binding]; other site
700598015160	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598015161	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
700598015162	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
700598015163	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
700598015164	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
700598015165	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598015166	aspartate aminotransferase; Provisional; Region: PRK05764
700598015167	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598015168	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598015169	homodimer interface [polypeptide binding]; other site
700598015170	catalytic residue [active]
700598015171	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
700598015172	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
700598015173	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
700598015174	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700598015175	catalytic core [active]
700598015176	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598015177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598015178	active site
700598015179	phosphorylation site [posttranslational modification]
700598015180	intermolecular recognition site; other site
700598015181	dimerization interface [polypeptide binding]; other site
700598015182	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598015183	DNA binding residues [nucleotide binding]
700598015184	dimerization interface [polypeptide binding]; other site
700598015185	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
700598015186	active site
700598015187	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598015188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598015189	active site
700598015190	phosphorylation site [posttranslational modification]
700598015191	intermolecular recognition site; other site
700598015192	dimerization interface [polypeptide binding]; other site
700598015193	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598015194	DNA binding residues [nucleotide binding]
700598015195	dimerization interface [polypeptide binding]; other site
700598015196	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598015197	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598015198	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598015199	putative active site [active]
700598015200	heme pocket [chemical binding]; other site
700598015201	PAS domain; Region: PAS; smart00091
700598015202	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
700598015203	GAF domain; Region: GAF_2; pfam13185
700598015204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598015205	PAS fold; Region: PAS_3; pfam08447
700598015206	putative active site [active]
700598015207	heme pocket [chemical binding]; other site
700598015208	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598015209	Histidine kinase; Region: HisKA_3; pfam07730
700598015210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598015211	ATP binding site [chemical binding]; other site
700598015212	Mg2+ binding site [ion binding]; other site
700598015213	G-X-G motif; other site
700598015214	SurA N-terminal domain; Region: SurA_N; pfam09312
700598015215	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
700598015216	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
700598015217	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
700598015218	translation initiation factor IF-2; Region: IF-2; TIGR00487
700598015219	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
700598015220	G1 box; other site
700598015221	putative GEF interaction site [polypeptide binding]; other site
700598015222	GTP/Mg2+ binding site [chemical binding]; other site
700598015223	Switch I region; other site
700598015224	G2 box; other site
700598015225	G3 box; other site
700598015226	Switch II region; other site
700598015227	G4 box; other site
700598015228	G5 box; other site
700598015229	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
700598015230	Translation-initiation factor 2; Region: IF-2; pfam11987
700598015231	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
700598015232	transcription termination factor NusA; Region: NusA; TIGR01953
700598015233	NusA N-terminal domain; Region: NusA_N; pfam08529
700598015234	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
700598015235	RNA binding site [nucleotide binding]; other site
700598015236	homodimer interface [polypeptide binding]; other site
700598015237	NusA-like KH domain; Region: KH_5; pfam13184
700598015238	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
700598015239	G-X-X-G motif; other site
700598015240	ribosome maturation protein RimP; Reviewed; Region: PRK00092
700598015241	Sm and related proteins; Region: Sm_like; cl00259
700598015242	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
700598015243	putative oligomer interface [polypeptide binding]; other site
700598015244	putative RNA binding site [nucleotide binding]; other site
700598015245	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
700598015246	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598015247	motif II; other site
700598015248	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
700598015249	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700598015250	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700598015251	Glycosyl hydrolase family 43; Region: GH43_3; cd08982
700598015252	active site
700598015253	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598015254	sugar binding site [chemical binding]; other site
700598015255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
700598015256	Putative glucoamylase; Region: Glycoamylase; pfam10091
700598015257	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598015258	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598015259	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598015260	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598015261	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598015262	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598015263	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598015264	FecR protein; Region: FecR; pfam04773
700598015265	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598015266	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598015267	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598015268	DNA binding residues [nucleotide binding]
700598015269	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598015270	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
700598015271	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
700598015272	HflX GTPase family; Region: HflX; cd01878
700598015273	G1 box; other site
700598015274	GTP/Mg2+ binding site [chemical binding]; other site
700598015275	Switch I region; other site
700598015276	G2 box; other site
700598015277	G3 box; other site
700598015278	Switch II region; other site
700598015279	G4 box; other site
700598015280	G5 box; other site
700598015281	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
700598015282	iron-sulfur cluster [ion binding]; other site
700598015283	[2Fe-2S] cluster binding site [ion binding]; other site
700598015284	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
700598015285	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
700598015286	Walker A motif; other site
700598015287	ATP binding site [chemical binding]; other site
700598015288	Walker B motif; other site
700598015289	TrwC relaxase; Region: TrwC; pfam08751
700598015290	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
700598015291	AAA domain; Region: AAA_30; pfam13604
700598015292	Family description; Region: UvrD_C_2; pfam13538
700598015293	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
700598015294	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
700598015295	Helix-turn-helix domain; Region: HTH_17; cl17695
700598015296	integrase; Provisional; Region: PRK09692
700598015297	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
700598015298	active site
700598015299	Int/Topo IB signature motif; other site
700598015300	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446
700598015301	putative RNA polymerase sigma E protein; Provisional; Region: PRK13919
700598015302	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
700598015303	DNA binding residues [nucleotide binding]
700598015304	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598015305	salt bridge; other site
700598015306	non-specific DNA binding site [nucleotide binding]; other site
700598015307	sequence-specific DNA binding site [nucleotide binding]; other site
700598015308	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
700598015309	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
700598015310	catalytic residues [active]
700598015311	catalytic nucleophile [active]
700598015312	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598015313	non-specific DNA binding site [nucleotide binding]; other site
700598015314	salt bridge; other site
700598015315	sequence-specific DNA binding site [nucleotide binding]; other site
700598015316	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598015317	Walker A/P-loop; other site
700598015318	ATP binding site [chemical binding]; other site
700598015319	Q-loop/lid; other site
700598015320	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
700598015321	HipA-like N-terminal domain; Region: HipA_N; pfam07805
700598015322	HipA-like C-terminal domain; Region: HipA_C; pfam07804
700598015323	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700598015324	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
700598015325	active site
700598015326	DNA binding site [nucleotide binding]
700598015327	Int/Topo IB signature motif; other site
700598015328	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700598015329	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700598015330	catalytic residues [active]
700598015331	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
700598015332	Methyltransferase domain; Region: Methyltransf_26; pfam13659
700598015333	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
700598015334	homotrimer interaction site [polypeptide binding]; other site
700598015335	putative active site [active]
700598015336	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
700598015337	HopJ type III effector protein; Region: HopJ; pfam08888
700598015338	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
700598015339	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700598015340	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
700598015341	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cd00385
700598015342	substrate binding pocket [chemical binding]; other site
700598015343	substrate-Mg2+ binding site; other site
700598015344	aspartate-rich region 1; other site
700598015345	aspartate-rich region 2; other site
700598015346	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
700598015347	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700598015348	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598015349	non-specific DNA binding site [nucleotide binding]; other site
700598015350	salt bridge; other site
700598015351	sequence-specific DNA binding site [nucleotide binding]; other site
700598015352	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
700598015353	Catalytic site [active]
700598015354	Erythromycin esterase; Region: Erythro_esteras; pfam05139
700598015355	Double zinc ribbon; Region: DZR; pfam12773
700598015356	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
700598015357	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
700598015358	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
700598015359	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700598015360	active site
700598015361	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
700598015362	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
700598015363	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
700598015364	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
700598015365	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598015366	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598015367	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598015368	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598015369	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598015370	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
700598015371	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
700598015372	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
700598015373	putative metal binding site [ion binding]; other site
700598015374	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
700598015375	Interdomain contacts; other site
700598015376	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
700598015377	dimerization interface [polypeptide binding]; other site
700598015378	DNA binding residues [nucleotide binding]
700598015379	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598015380	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598015381	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598015382	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598015383	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598015384	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
700598015385	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598015386	non-specific DNA binding site [nucleotide binding]; other site
700598015387	salt bridge; other site
700598015388	sequence-specific DNA binding site [nucleotide binding]; other site
700598015389	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700598015390	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
700598015391	putative active site [active]
700598015392	putative metal binding site [ion binding]; other site
700598015393	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
700598015394	active site
700598015395	catalytic site [active]
700598015396	substrate binding site [chemical binding]; other site
700598015397	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
700598015398	GldM N-terminal domain; Region: GldM_N; pfam12081
700598015399	GldM N-terminal domain; Region: GldM_N; pfam12081
700598015400	GldM N-terminal domain; Region: GldM_N; pfam12081
700598015401	GldM N-terminal domain; Region: GldM_N; pfam12081
700598015402	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
700598015403	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
700598015404	active site
700598015405	nucleophile elbow; other site
700598015406	FIST N domain; Region: FIST; pfam08495
700598015407	FIST C domain; Region: FIST_C; pfam10442
700598015408	PAS domain S-box; Region: sensory_box; TIGR00229
700598015409	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
700598015410	PAS fold; Region: PAS_7; pfam12860
700598015411	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
700598015412	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598015413	putative active site [active]
700598015414	heme pocket [chemical binding]; other site
700598015415	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598015416	dimer interface [polypeptide binding]; other site
700598015417	phosphorylation site [posttranslational modification]
700598015418	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598015419	ATP binding site [chemical binding]; other site
700598015420	Mg2+ binding site [ion binding]; other site
700598015421	G-X-G motif; other site
700598015422	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598015423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598015424	active site
700598015425	phosphorylation site [posttranslational modification]
700598015426	intermolecular recognition site; other site
700598015427	dimerization interface [polypeptide binding]; other site
700598015428	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
700598015429	putative binding surface; other site
700598015430	active site
700598015431	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
700598015432	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598015433	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700598015434	RDD family; Region: RDD; pfam06271
700598015435	Peptidase S46; Region: Peptidase_S46; pfam10459
700598015436	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700598015437	GTPase CgtA; Reviewed; Region: obgE; PRK12299
700598015438	GTP1/OBG; Region: GTP1_OBG; pfam01018
700598015439	Obg GTPase; Region: Obg; cd01898
700598015440	G1 box; other site
700598015441	GTP/Mg2+ binding site [chemical binding]; other site
700598015442	Switch I region; other site
700598015443	G2 box; other site
700598015444	G3 box; other site
700598015445	Switch II region; other site
700598015446	G4 box; other site
700598015447	G5 box; other site
700598015448	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
700598015449	four helix bundle protein; Region: TIGR02436
700598015450	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
700598015451	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
700598015452	putative trimer interface [polypeptide binding]; other site
700598015453	putative CoA binding site [chemical binding]; other site
700598015454	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598015455	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598015456	active site
700598015457	catalytic tetrad [active]
700598015458	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700598015459	CoenzymeA binding site [chemical binding]; other site
700598015460	subunit interaction site [polypeptide binding]; other site
700598015461	PHB binding site; other site
700598015462	enoyl-CoA hydratase; Provisional; Region: PRK08140
700598015463	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700598015464	substrate binding site [chemical binding]; other site
700598015465	oxyanion hole (OAH) forming residues; other site
700598015466	trimer interface [polypeptide binding]; other site
700598015467	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
700598015468	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
700598015469	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
700598015470	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
700598015471	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
700598015472	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
700598015473	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598015474	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
700598015475	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598015476	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598015477	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
700598015478	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598015479	Outer membrane efflux protein; Region: OEP; pfam02321
700598015480	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
700598015481	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
700598015482	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
700598015483	Histidine kinase; Region: His_kinase; pfam06580
700598015484	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598015485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598015486	active site
700598015487	phosphorylation site [posttranslational modification]
700598015488	intermolecular recognition site; other site
700598015489	dimerization interface [polypeptide binding]; other site
700598015490	LytTr DNA-binding domain; Region: LytTR; smart00850
700598015491	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
700598015492	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
700598015493	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
700598015494	mce related protein; Region: MCE; pfam02470
700598015495	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
700598015496	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
700598015497	Walker A/P-loop; other site
700598015498	ATP binding site [chemical binding]; other site
700598015499	Q-loop/lid; other site
700598015500	ABC transporter signature motif; other site
700598015501	Walker B; other site
700598015502	D-loop; other site
700598015503	H-loop/switch region; other site
700598015504	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700598015505	Permease; Region: Permease; pfam02405
700598015506	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
700598015507	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
700598015508	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
700598015509	active site
700598015510	catalytic residues [active]
700598015511	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700598015512	Predicted flavoprotein [General function prediction only]; Region: COG0431
700598015513	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
700598015514	Response regulator receiver domain; Region: Response_reg; pfam00072
700598015515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598015516	active site
700598015517	phosphorylation site [posttranslational modification]
700598015518	intermolecular recognition site; other site
700598015519	dimerization interface [polypeptide binding]; other site
700598015520	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
700598015521	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598015522	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598015523	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
700598015524	active site
700598015525	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598015526	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598015527	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139
700598015528	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
700598015529	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
700598015530	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
700598015531	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
700598015532	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
700598015533	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
700598015534	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
700598015535	inhibitor-cofactor binding pocket; inhibition site
700598015536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598015537	catalytic residue [active]
700598015538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
700598015539	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
700598015540	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700598015541	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
700598015542	DinB superfamily; Region: DinB_2; pfam12867
700598015543	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598015544	Radical SAM superfamily; Region: Radical_SAM; pfam04055
700598015545	FeS/SAM binding site; other site
700598015546	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
700598015547	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
700598015548	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
700598015549	active site
700598015550	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
700598015551	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
700598015552	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
700598015553	SnoaL-like domain; Region: SnoaL_3; pfam13474
700598015554	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
700598015555	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
700598015556	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
700598015557	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598015558	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700598015559	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
700598015560	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
700598015561	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700598015562	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
700598015563	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598015564	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598015565	putative substrate translocation pore; other site
700598015566	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598015567	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598015568	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700598015569	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
700598015570	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
700598015571	Cytochrome c; Region: Cytochrom_C; cl11414
700598015572	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
700598015573	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
700598015574	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598015575	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598015576	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
700598015577	Repair protein; Region: Repair_PSII; pfam04536
700598015578	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
700598015579	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598015580	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598015581	DNA binding residues [nucleotide binding]
700598015582	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
700598015583	ArsC family; Region: ArsC; pfam03960
700598015584	catalytic residue [active]
700598015585	Transposase IS200 like; Region: Y1_Tnp; cl00848
700598015586	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
700598015587	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
700598015588	Histidine kinase; Region: His_kinase; pfam06580
700598015589	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598015590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598015591	active site
700598015592	phosphorylation site [posttranslational modification]
700598015593	intermolecular recognition site; other site
700598015594	dimerization interface [polypeptide binding]; other site
700598015595	LytTr DNA-binding domain; Region: LytTR; smart00850
700598015596	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
700598015597	Part of AAA domain; Region: AAA_19; pfam13245
700598015598	Family description; Region: UvrD_C_2; pfam13538
700598015599	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
700598015600	Zn binding site [ion binding]; other site
700598015601	PIF1-like helicase; Region: PIF1; pfam05970
700598015602	AAA domain; Region: AAA_30; pfam13604
700598015603	Family description; Region: UvrD_C_2; pfam13538
700598015604	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700598015605	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
700598015606	active site
700598015607	META domain; Region: META; pfam03724
700598015608	Predicted metalloprotease [General function prediction only]; Region: COG2321
700598015609	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
700598015610	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
700598015611	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598015612	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598015613	dimer interface [polypeptide binding]; other site
700598015614	phosphorylation site [posttranslational modification]
700598015615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598015616	ATP binding site [chemical binding]; other site
700598015617	Mg2+ binding site [ion binding]; other site
700598015618	G-X-G motif; other site
700598015619	Response regulator receiver domain; Region: Response_reg; pfam00072
700598015620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598015621	active site
700598015622	phosphorylation site [posttranslational modification]
700598015623	intermolecular recognition site; other site
700598015624	dimerization interface [polypeptide binding]; other site
700598015625	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598015626	ligand binding site [chemical binding]; other site
700598015627	recombinase A; Provisional; Region: recA; PRK09354
700598015628	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
700598015629	hexamer interface [polypeptide binding]; other site
700598015630	Walker A motif; other site
700598015631	ATP binding site [chemical binding]; other site
700598015632	Walker B motif; other site
700598015633	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598015634	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
700598015635	active site
700598015636	dimer interfaces [polypeptide binding]; other site
700598015637	catalytic residues [active]
700598015638	excinuclease ABC subunit B; Provisional; Region: PRK05298
700598015639	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598015640	ATP binding site [chemical binding]; other site
700598015641	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598015642	nucleotide binding region [chemical binding]; other site
700598015643	ATP-binding site [chemical binding]; other site
700598015644	Ultra-violet resistance protein B; Region: UvrB; pfam12344
700598015645	UvrB/uvrC motif; Region: UVR; pfam02151
700598015646	DNA polymerase I; Provisional; Region: PRK05755
700598015647	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
700598015648	active site
700598015649	metal binding site 1 [ion binding]; metal-binding site
700598015650	putative 5' ssDNA interaction site; other site
700598015651	metal binding site 3; metal-binding site
700598015652	metal binding site 2 [ion binding]; metal-binding site
700598015653	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
700598015654	putative DNA binding site [nucleotide binding]; other site
700598015655	putative metal binding site [ion binding]; other site
700598015656	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
700598015657	active site
700598015658	catalytic site [active]
700598015659	substrate binding site [chemical binding]; other site
700598015660	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
700598015661	active site
700598015662	DNA binding site [nucleotide binding]
700598015663	catalytic site [active]
700598015664	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
700598015665	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
700598015666	TMP-binding site; other site
700598015667	ATP-binding site [chemical binding]; other site
700598015668	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
700598015669	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
700598015670	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
700598015671	catalytic residues [active]
700598015672	Amidohydrolase; Region: Amidohydro_2; pfam04909
700598015673	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
700598015674	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
700598015675	Histidine kinase; Region: His_kinase; pfam06580
700598015676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598015677	Response regulator receiver domain; Region: Response_reg; pfam00072
700598015678	active site
700598015679	phosphorylation site [posttranslational modification]
700598015680	intermolecular recognition site; other site
700598015681	dimerization interface [polypeptide binding]; other site
700598015682	LytTr DNA-binding domain; Region: LytTR; smart00850
700598015683	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
700598015684	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
700598015685	active site
700598015686	Zn binding site [ion binding]; other site
700598015687	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
700598015688	metal binding site 2 [ion binding]; metal-binding site
700598015689	putative DNA binding helix; other site
700598015690	metal binding site 1 [ion binding]; metal-binding site
700598015691	dimer interface [polypeptide binding]; other site
700598015692	structural Zn2+ binding site [ion binding]; other site
700598015693	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
700598015694	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
700598015695	Cu(I) binding site [ion binding]; other site
700598015696	MerC mercury resistance protein; Region: MerC; pfam03203
700598015697	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
700598015698	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
700598015699	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598015700	hydrophobic ligand binding site; other site
700598015701	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
700598015702	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
700598015703	NADP binding site [chemical binding]; other site
700598015704	homodimer interface [polypeptide binding]; other site
700598015705	substrate binding site [chemical binding]; other site
700598015706	active site
700598015707	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
700598015708	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
700598015709	AAA domain; Region: AAA_28; pfam13521
700598015710	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
700598015711	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
700598015712	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
700598015713	Transglycosylase; Region: Transgly; cl17702
700598015714	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
700598015715	GH3 auxin-responsive promoter; Region: GH3; pfam03321
700598015716	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598015717	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
700598015718	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
700598015719	active site
700598015720	dimerization interface [polypeptide binding]; other site
700598015721	thiamine monophosphate kinase; Provisional; Region: PRK05731
700598015722	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
700598015723	ATP binding site [chemical binding]; other site
700598015724	dimerization interface [polypeptide binding]; other site
700598015725	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
700598015726	Active site serine [active]
700598015727	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598015728	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
700598015729	active site
700598015730	C-N hydrolase family amidase; Provisional; Region: PRK10438
700598015731	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
700598015732	putative active site [active]
700598015733	catalytic triad [active]
700598015734	dimer interface [polypeptide binding]; other site
700598015735	multimer interface [polypeptide binding]; other site
700598015736	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
700598015737	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598015738	Coenzyme A binding pocket [chemical binding]; other site
700598015739	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598015740	Coenzyme A binding pocket [chemical binding]; other site
700598015741	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
700598015742	active site
700598015743	alpha-glucosidase; Provisional; Region: PRK10137
700598015744	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
700598015745	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
700598015746	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
700598015747	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
700598015748	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
700598015749	dimer interface [polypeptide binding]; other site
700598015750	active site residues [active]
700598015751	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
700598015752	Chromate transporter; Region: Chromate_transp; pfam02417
700598015753	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
700598015754	Chromate transporter; Region: Chromate_transp; pfam02417
700598015755	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
700598015756	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
700598015757	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
700598015758	active site
700598015759	(T/H)XGH motif; other site
700598015760	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
700598015761	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
700598015762	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
700598015763	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
700598015764	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
700598015765	NIPSNAP; Region: NIPSNAP; pfam07978
700598015766	NIPSNAP; Region: NIPSNAP; pfam07978
700598015767	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
700598015768	GAF domain; Region: GAF_2; pfam13185
700598015769	quinolinate synthetase; Provisional; Region: PRK09375
700598015770	SurA N-terminal domain; Region: SurA_N_3; cl07813
700598015771	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
700598015772	Protein of unknown function (DUF2480); Region: DUF2480; pfam10652
700598015773	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
700598015774	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
700598015775	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
700598015776	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
700598015777	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
700598015778	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
700598015779	oligomer interface [polypeptide binding]; other site
700598015780	metal binding site [ion binding]; metal-binding site
700598015781	metal binding site [ion binding]; metal-binding site
700598015782	Cl binding site [ion binding]; other site
700598015783	aspartate ring; other site
700598015784	basic sphincter; other site
700598015785	putative hydrophobic gate; other site
700598015786	periplasmic entrance; other site
700598015787	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
700598015788	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
700598015789	active site
700598015790	NAD binding site [chemical binding]; other site
700598015791	metal binding site [ion binding]; metal-binding site
700598015792	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
700598015793	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
700598015794	substrate binding [chemical binding]; other site
700598015795	active site
700598015796	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
700598015797	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
700598015798	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
700598015799	dimer interface [polypeptide binding]; other site
700598015800	decamer (pentamer of dimers) interface [polypeptide binding]; other site
700598015801	catalytic triad [active]
700598015802	peroxidatic and resolving cysteines [active]
700598015803	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
700598015804	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
700598015805	fructokinase; Reviewed; Region: PRK09557
700598015806	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700598015807	nucleotide binding site [chemical binding]; other site
700598015808	Glucokinase; Region: Glucokinase; cl17310
700598015809	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
700598015810	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
700598015811	Ligand binding site; other site
700598015812	oligomer interface; other site
700598015813	Uncharacterized conserved protein [Function unknown]; Region: COG2308
700598015814	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
700598015815	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
700598015816	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
700598015817	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
700598015818	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
700598015819	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
700598015820	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
700598015821	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
700598015822	DNA polymerase III subunit beta; Validated; Region: PRK05643
700598015823	putative DNA binding surface [nucleotide binding]; other site
700598015824	dimer interface [polypeptide binding]; other site
700598015825	beta-clamp/translesion DNA polymerase binding surface; other site
700598015826	beta-clamp/clamp loader binding surface; other site
700598015827	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700598015828	RecX family; Region: RecX; pfam02631
700598015829	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
700598015830	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598015831	putative active site [active]
700598015832	heme pocket [chemical binding]; other site
700598015833	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598015834	dimer interface [polypeptide binding]; other site
700598015835	phosphorylation site [posttranslational modification]
700598015836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598015837	ATP binding site [chemical binding]; other site
700598015838	Mg2+ binding site [ion binding]; other site
700598015839	G-X-G motif; other site
700598015840	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700598015841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598015842	active site
700598015843	phosphorylation site [posttranslational modification]
700598015844	intermolecular recognition site; other site
700598015845	dimerization interface [polypeptide binding]; other site
700598015846	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
700598015847	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
700598015848	NlpE N-terminal domain; Region: NlpE; pfam04170
700598015849	Predicted membrane protein [Function unknown]; Region: COG3650
700598015850	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
700598015851	Zn binding site [ion binding]; other site
700598015852	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
700598015853	Transglycosylase; Region: Transgly; pfam00912
700598015854	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
700598015855	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
700598015856	EamA-like transporter family; Region: EamA; pfam00892
700598015857	EamA-like transporter family; Region: EamA; pfam00892
700598015858	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598015859	putative DNA binding site [nucleotide binding]; other site
700598015860	dimerization interface [polypeptide binding]; other site
700598015861	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
700598015862	putative Zn2+ binding site [ion binding]; other site
700598015863	AsnC family; Region: AsnC_trans_reg; pfam01037
700598015864	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
700598015865	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
700598015866	metal ion-dependent adhesion site (MIDAS); other site
700598015867	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
700598015868	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
700598015869	putative dimer interface [polypeptide binding]; other site
700598015870	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
700598015871	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
700598015872	CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704
700598015873	Asparaginase; Region: Asparaginase; pfam00710
700598015874	active site
700598015875	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598015876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598015877	active site
700598015878	phosphorylation site [posttranslational modification]
700598015879	intermolecular recognition site; other site
700598015880	dimerization interface [polypeptide binding]; other site
700598015881	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598015882	DNA binding site [nucleotide binding]
700598015883	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598015884	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598015885	dimerization interface [polypeptide binding]; other site
700598015886	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598015887	dimer interface [polypeptide binding]; other site
700598015888	phosphorylation site [posttranslational modification]
700598015889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598015890	ATP binding site [chemical binding]; other site
700598015891	Mg2+ binding site [ion binding]; other site
700598015892	G-X-G motif; other site
700598015893	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598015894	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
700598015895	elongation factor G; Reviewed; Region: PRK12739
700598015896	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
700598015897	G1 box; other site
700598015898	putative GEF interaction site [polypeptide binding]; other site
700598015899	GTP/Mg2+ binding site [chemical binding]; other site
700598015900	Switch I region; other site
700598015901	G2 box; other site
700598015902	G3 box; other site
700598015903	Switch II region; other site
700598015904	G4 box; other site
700598015905	G5 box; other site
700598015906	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
700598015907	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
700598015908	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
700598015909	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598015910	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598015911	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598015912	DNA binding residues [nucleotide binding]
700598015913	FecR protein; Region: FecR; pfam04773
700598015914	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598015915	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598015916	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598015917	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598015918	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598015919	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598015920	KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592
700598015921	putative active site [active]
700598015922	putative catalytic site [active]
700598015923	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
700598015924	putative active site [active]
700598015925	putative metal binding site [ion binding]; other site
700598015926	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
700598015927	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
700598015928	putative sugar binding sites [chemical binding]; other site
700598015929	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
700598015930	Q-X-W motif; other site
700598015931	Bacterial SH3 domain; Region: SH3_3; pfam08239
700598015932	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
700598015933	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
700598015934	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
700598015935	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
700598015936	ligand binding site [chemical binding]; other site
700598015937	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
700598015938	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
700598015939	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598015940	ATP binding site [chemical binding]; other site
700598015941	putative Mg++ binding site [ion binding]; other site
700598015942	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598015943	nucleotide binding region [chemical binding]; other site
700598015944	ATP-binding site [chemical binding]; other site
700598015945	RQC domain; Region: RQC; pfam09382
700598015946	HRDC domain; Region: HRDC; pfam00570
700598015947	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
700598015948	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
700598015949	putative active site [active]
700598015950	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
700598015951	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
700598015952	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
700598015953	Substrate binding site; other site
700598015954	Cupin domain; Region: Cupin_2; cl17218
700598015955	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
700598015956	active site
700598015957	catalytic site [active]
700598015958	substrate binding site [chemical binding]; other site
700598015959	Protein of unknown function (DUF419); Region: DUF419; pfam04237
700598015960	methionine aminotransferase; Validated; Region: PRK09082
700598015961	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598015962	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598015963	homodimer interface [polypeptide binding]; other site
700598015964	catalytic residue [active]
700598015965	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
700598015966	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700598015967	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700598015968	Coenzyme A binding pocket [chemical binding]; other site
700598015969	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
700598015970	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
700598015971	G1 box; other site
700598015972	GTP/Mg2+ binding site [chemical binding]; other site
700598015973	Switch I region; other site
700598015974	G2 box; other site
700598015975	G3 box; other site
700598015976	Switch II region; other site
700598015977	G4 box; other site
700598015978	G5 box; other site
700598015979	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598015980	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
700598015981	Nucleoside recognition; Region: Gate; pfam07670
700598015982	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
700598015983	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
700598015984	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
700598015985	putative ligand binding site [chemical binding]; other site
700598015986	putative NAD binding site [chemical binding]; other site
700598015987	catalytic site [active]
700598015988	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
700598015989	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
700598015990	putative dimer interface [polypeptide binding]; other site
700598015991	putative anticodon binding site; other site
700598015992	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
700598015993	homodimer interface [polypeptide binding]; other site
700598015994	motif 1; other site
700598015995	motif 2; other site
700598015996	active site
700598015997	motif 3; other site
700598015998	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598015999	Ligand Binding Site [chemical binding]; other site
700598016000	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598016001	Ligand Binding Site [chemical binding]; other site
700598016002	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
700598016003	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
700598016004	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
700598016005	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
700598016006	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
700598016007	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
700598016008	Predicted transcriptional regulators [Transcription]; Region: COG1695
700598016009	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
700598016010	PspC domain; Region: PspC; pfam04024
700598016011	PspC domain; Region: PspC; pfam04024
700598016012	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
700598016013	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
700598016014	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
700598016015	putative hydrophobic ligand binding site [chemical binding]; other site
700598016016	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
700598016017	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
700598016018	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
700598016019	transcription termination factor Rho; Provisional; Region: PRK12608
700598016020	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
700598016021	RNA binding site [nucleotide binding]; other site
700598016022	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
700598016023	multimer interface [polypeptide binding]; other site
700598016024	Walker A motif; other site
700598016025	ATP binding site [chemical binding]; other site
700598016026	Walker B motif; other site
700598016027	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
700598016028	aromatic arch; other site
700598016029	DCoH dimer interaction site [polypeptide binding]; other site
700598016030	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
700598016031	DCoH tetramer interaction site [polypeptide binding]; other site
700598016032	substrate binding site [chemical binding]; other site
700598016033	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700598016034	M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663
700598016035	Peptidase family M28; Region: Peptidase_M28; pfam04389
700598016036	metal binding site [ion binding]; metal-binding site
700598016037	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
700598016038	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700598016039	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
700598016040	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
700598016041	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598016042	ATP binding site [chemical binding]; other site
700598016043	putative Mg++ binding site [ion binding]; other site
700598016044	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598016045	nucleotide binding region [chemical binding]; other site
700598016046	ATP-binding site [chemical binding]; other site
700598016047	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598016048	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598016049	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598016050	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
700598016051	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
700598016052	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
700598016053	catalytic site [active]
700598016054	active site
700598016055	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
700598016056	GLPGLI family protein; Region: GLPGLI; TIGR01200
700598016057	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598016058	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598016059	dimer interface [polypeptide binding]; other site
700598016060	phosphorylation site [posttranslational modification]
700598016061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598016062	ATP binding site [chemical binding]; other site
700598016063	Mg2+ binding site [ion binding]; other site
700598016064	G-X-G motif; other site
700598016065	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598016066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598016067	active site
700598016068	phosphorylation site [posttranslational modification]
700598016069	intermolecular recognition site; other site
700598016070	dimerization interface [polypeptide binding]; other site
700598016071	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598016072	DNA binding site [nucleotide binding]
700598016073	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598016074	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598016075	putative active site [active]
700598016076	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598016077	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
700598016078	putative active site [active]
700598016079	heme pocket [chemical binding]; other site
700598016080	PAS domain; Region: PAS; smart00091
700598016081	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700598016082	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598016083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598016084	dimer interface [polypeptide binding]; other site
700598016085	phosphorylation site [posttranslational modification]
700598016086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598016087	ATP binding site [chemical binding]; other site
700598016088	Mg2+ binding site [ion binding]; other site
700598016089	G-X-G motif; other site
700598016090	Response regulator receiver domain; Region: Response_reg; pfam00072
700598016091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598016092	active site
700598016093	phosphorylation site [posttranslational modification]
700598016094	intermolecular recognition site; other site
700598016095	dimerization interface [polypeptide binding]; other site
700598016096	Response regulator receiver domain; Region: Response_reg; pfam00072
700598016097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598016098	active site
700598016099	phosphorylation site [posttranslational modification]
700598016100	intermolecular recognition site; other site
700598016101	dimerization interface [polypeptide binding]; other site
700598016102	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
700598016103	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598016104	FeS/SAM binding site; other site
700598016105	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
700598016106	catalytic motif [active]
700598016107	Catalytic residue [active]
700598016108	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
700598016109	catalytic motif [active]
700598016110	Catalytic residue [active]
700598016111	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
700598016112	protein binding site [polypeptide binding]; other site
700598016113	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
700598016114	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
700598016115	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
700598016116	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
700598016117	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
700598016118	Membrane protein of unknown function; Region: DUF360; pfam04020
700598016119	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
700598016120	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
700598016121	tetramer interface [polypeptide binding]; other site
700598016122	TPP-binding site [chemical binding]; other site
700598016123	heterodimer interface [polypeptide binding]; other site
700598016124	phosphorylation loop region [posttranslational modification]
700598016125	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
700598016126	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
700598016127	alpha subunit interface [polypeptide binding]; other site
700598016128	TPP binding site [chemical binding]; other site
700598016129	heterodimer interface [polypeptide binding]; other site
700598016130	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700598016131	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
700598016132	putative active site [active]
700598016133	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
700598016134	Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228
700598016135	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
700598016136	Catalytic dyad [active]
700598016137	Penicillin amidase; Region: Penicil_amidase; pfam01804
700598016138	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
700598016139	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
700598016140	active site
700598016141	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
700598016142	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
700598016143	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
700598016144	active site
700598016145	putative substrate binding pocket [chemical binding]; other site
700598016146	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598016147	CsbD-like; Region: CsbD; cl17424
700598016148	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
700598016149	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700598016150	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598016151	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598016152	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
700598016153	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598016154	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598016155	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
700598016156	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
700598016157	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598016158	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598016159	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
700598016160	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
700598016161	active site
700598016162	substrate binding site [chemical binding]; other site
700598016163	cosubstrate binding site; other site
700598016164	catalytic site [active]
700598016165	Cytochrome c; Region: Cytochrom_C; cl11414
700598016166	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
700598016167	heme-binding residues [chemical binding]; other site
700598016168	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
700598016169	heme-binding residues [chemical binding]; other site
700598016170	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
700598016171	molybdopterin cofactor binding site; other site
700598016172	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
700598016173	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
700598016174	4Fe-4S binding domain; Region: Fer4_2; pfam12797
700598016175	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
700598016176	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
700598016177	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
700598016178	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
700598016179	Cytochrome c; Region: Cytochrom_C; pfam00034
700598016180	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
700598016181	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
700598016182	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
700598016183	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
700598016184	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
700598016185	protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473
700598016186	UbiA prenyltransferase family; Region: UbiA; pfam01040
700598016187	Subunit I/III interface [polypeptide binding]; other site
700598016188	Heme/copper-type cytochrome/quinol oxidase, subunit 3 [Energy production and conversion]; Region: CyoC; COG1845
700598016189	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
700598016190	Subunit I/III interface [polypeptide binding]; other site
700598016191	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626
700598016192	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
700598016193	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
700598016194	Cu(I) binding site [ion binding]; other site
700598016195	Protein of unknown function (DUF420); Region: DUF420; pfam04238
700598016196	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
700598016197	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700598016198	putative NAD(P) binding site [chemical binding]; other site
700598016199	catalytic Zn binding site [ion binding]; other site
700598016200	structural Zn binding site [ion binding]; other site
700598016201	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
700598016202	DNA binding site [nucleotide binding]
700598016203	active site
700598016204	Putative methyltransferase; Region: Methyltransf_4; cl17290
700598016205	short chain dehydrogenase; Provisional; Region: PRK06500
700598016206	classical (c) SDRs; Region: SDR_c; cd05233
700598016207	NAD(P) binding site [chemical binding]; other site
700598016208	active site
700598016209	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598016210	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598016211	ligand binding site [chemical binding]; other site
700598016212	flexible hinge region; other site
700598016213	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
700598016214	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
700598016215	putative DNA binding site [nucleotide binding]; other site
700598016216	putative Zn2+ binding site [ion binding]; other site
700598016217	AsnC family; Region: AsnC_trans_reg; pfam01037
700598016218	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
700598016219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700598016220	dimer interface [polypeptide binding]; other site
700598016221	conserved gate region; other site
700598016222	putative PBP binding loops; other site
700598016223	ABC-ATPase subunit interface; other site
700598016224	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
700598016225	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192
700598016226	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700598016227	Serine hydrolase (FSH1); Region: FSH1; pfam03959
700598016228	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700598016229	MarR family; Region: MarR; pfam01047
700598016230	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700598016231	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700598016232	active site
700598016233	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
700598016234	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700598016235	Zn2+ binding site [ion binding]; other site
700598016236	Mg2+ binding site [ion binding]; other site
700598016237	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
700598016238	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
700598016239	Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; cl01770
700598016240	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
700598016241	putative active site [active]
700598016242	putative catalytic site [active]
700598016243	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598016244	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
700598016245	Ligand binding site; other site
700598016246	Putative Catalytic site; other site
700598016247	DXD motif; other site
700598016248	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
700598016249	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
700598016250	putative active site [active]
700598016251	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
700598016252	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
700598016253	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
700598016254	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700598016255	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
700598016256	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
700598016257	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263
700598016258	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
700598016259	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
700598016260	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598016261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598016262	ATP binding site [chemical binding]; other site
700598016263	Mg2+ binding site [ion binding]; other site
700598016264	G-X-G motif; other site
700598016265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598016266	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598016267	putative substrate translocation pore; other site
700598016268	hypothetical protein; Provisional; Region: PRK11770
700598016269	Domain of unknown function (DUF307); Region: DUF307; pfam03733
700598016270	Domain of unknown function (DUF307); Region: DUF307; pfam03733
700598016271	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
700598016272	Peptidase family M23; Region: Peptidase_M23; pfam01551
700598016273	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598016274	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700598016275	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
700598016276	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598016277	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
700598016278	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
700598016279	TPP-binding site [chemical binding]; other site
700598016280	Cupin-like domain; Region: Cupin_8; pfam13621
700598016281	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
700598016282	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
700598016283	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
700598016284	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
700598016285	RNA/DNA hybrid binding site [nucleotide binding]; other site
700598016286	active site
700598016287	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598016288	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598016289	ligand binding site [chemical binding]; other site
700598016290	flexible hinge region; other site
700598016291	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700598016292	non-specific DNA interactions [nucleotide binding]; other site
700598016293	DNA binding site [nucleotide binding]
700598016294	sequence specific DNA binding site [nucleotide binding]; other site
700598016295	putative cAMP binding site [chemical binding]; other site
700598016296	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700598016297	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700598016298	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
700598016299	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700598016300	active site residue [active]
700598016301	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700598016302	active site residue [active]
700598016303	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
700598016304	Predicted transporter component [General function prediction only]; Region: COG2391
700598016305	Sulphur transport; Region: Sulf_transp; pfam04143
700598016306	Cytochrome c [Energy production and conversion]; Region: COG3258
700598016307	Cytochrome c; Region: Cytochrom_C; pfam00034
700598016308	DsrE/DsrF-like family; Region: DrsE; cl00672
700598016309	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
700598016310	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
700598016311	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
700598016312	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
700598016313	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
700598016314	methionine sulfoxide reductase A; Provisional; Region: PRK14054
700598016315	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598016316	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
700598016317	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
700598016318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
700598016319	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
700598016320	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
700598016321	G1 box; other site
700598016322	putative GEF interaction site [polypeptide binding]; other site
700598016323	GTP/Mg2+ binding site [chemical binding]; other site
700598016324	Switch I region; other site
700598016325	G2 box; other site
700598016326	G3 box; other site
700598016327	Switch II region; other site
700598016328	G4 box; other site
700598016329	G5 box; other site
700598016330	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
700598016331	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
700598016332	RDD family; Region: RDD; pfam06271
700598016333	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
700598016334	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
700598016335	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598016336	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598016337	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
700598016338	putative metal binding site; other site
700598016339	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598016340	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598016341	active site
700598016342	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
700598016343	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
700598016344	Walker A; other site
700598016345	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
700598016346	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598016347	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
700598016348	putative active site [active]
700598016349	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
700598016350	Type III pantothenate kinase; Region: Pan_kinase; cl17198
700598016351	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
700598016352	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
700598016353	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598016354	active site
700598016355	catalytic tetrad [active]
700598016356	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598016357	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598016358	Outer membrane efflux protein; Region: OEP; pfam02321
700598016359	Outer membrane efflux protein; Region: OEP; pfam02321
700598016360	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
700598016361	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598016362	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598016363	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
700598016364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598016365	putative substrate translocation pore; other site
700598016366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598016367	short chain dehydrogenase; Provisional; Region: PRK08278
700598016368	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598016369	NAD(P) binding site [chemical binding]; other site
700598016370	active site
700598016371	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
700598016372	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
700598016373	dimer interface [polypeptide binding]; other site
700598016374	putative anticodon binding site; other site
700598016375	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
700598016376	motif 1; other site
700598016377	active site
700598016378	motif 2; other site
700598016379	motif 3; other site
700598016380	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
700598016381	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
700598016382	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
700598016383	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
700598016384	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
700598016385	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
700598016386	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
700598016387	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700598016388	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
700598016389	NodB motif; other site
700598016390	active site
700598016391	catalytic site [active]
700598016392	metal binding site [ion binding]; metal-binding site
700598016393	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700598016394	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
700598016395	putative di-iron ligands [ion binding]; other site
700598016396	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
700598016397	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
700598016398	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
700598016399	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
700598016400	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
700598016401	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
700598016402	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
700598016403	homodimer interface [polypeptide binding]; other site
700598016404	substrate-cofactor binding pocket; other site
700598016405	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598016406	catalytic residue [active]
700598016407	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
700598016408	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
700598016409	active site
700598016410	dimer interface [polypeptide binding]; other site
700598016411	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
700598016412	Ligand Binding Site [chemical binding]; other site
700598016413	Molecular Tunnel; other site
700598016414	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
700598016415	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
700598016416	Protein of unknown function, DUF479; Region: DUF479; cl01203
700598016417	deoxyhypusine synthase; Region: dhys; TIGR00321
700598016418	Deoxyhypusine synthase; Region: DS; cl00826
700598016419	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
700598016420	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
700598016421	Sulfatase; Region: Sulfatase; pfam00884
700598016422	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
700598016423	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
700598016424	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
700598016425	Domain of unknown function DUF21; Region: DUF21; pfam01595
700598016426	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
700598016427	Transporter associated domain; Region: CorC_HlyC; smart01091
700598016428	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
700598016429	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
700598016430	catalytic site [active]
700598016431	G-X2-G-X-G-K; other site
700598016432	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
700598016433	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
700598016434	hinge; other site
700598016435	active site
700598016436	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
700598016437	gliding motility-associated protein GldC; Region: GldC; TIGR03515
700598016438	Yqey-like protein; Region: YqeY; cl17540
700598016439	Colicin V production protein; Region: Colicin_V; pfam02674
700598016440	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
700598016441	FOG: CBS domain [General function prediction only]; Region: COG0517
700598016442	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
700598016443	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
700598016444	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
700598016445	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
700598016446	ATP-NAD kinase; Region: NAD_kinase; pfam01513
700598016447	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598016448	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
700598016449	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
700598016450	catalytic residue [active]
700598016451	putative FPP diphosphate  binding site; other site
700598016452	putative FPP binding hydrophobic cleft; other site
700598016453	dimer interface [polypeptide binding]; other site
700598016454	putative IPP diphosphate binding site; other site
700598016455	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
700598016456	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
700598016457	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
700598016458	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
700598016459	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
700598016460	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598016461	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
700598016462	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
700598016463	glutamate racemase; Provisional; Region: PRK00865
700598016464	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
700598016465	ribonuclease P; Reviewed; Region: rnpA; PRK01903
700598016466	Haemolytic domain; Region: Haemolytic; pfam01809
700598016467	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
700598016468	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
700598016469	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
700598016470	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
700598016471	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598016472	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598016473	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598016474	DNA binding residues [nucleotide binding]
700598016475	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598016476	FecR protein; Region: FecR; pfam04773
700598016477	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598016478	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598016479	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598016480	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598016481	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598016482	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598016483	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
700598016484	nucleoside/Zn binding site; other site
700598016485	dimer interface [polypeptide binding]; other site
700598016486	catalytic motif [active]
700598016487	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
700598016488	fructuronate transporter; Provisional; Region: PRK10034; cl15264
700598016489	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
700598016490	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
700598016491	NAD(P) binding site [chemical binding]; other site
700598016492	catalytic residues [active]
700598016493	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
700598016494	catalytic residues [active]
700598016495	dimer interface [polypeptide binding]; other site
700598016496	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
700598016497	four helix bundle protein; Region: TIGR02436
700598016498	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
700598016499	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700598016500	Peptidase family M28; Region: Peptidase_M28; pfam04389
700598016501	metal binding site [ion binding]; metal-binding site
700598016502	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
700598016503	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
700598016504	FMN binding site [chemical binding]; other site
700598016505	active site
700598016506	catalytic residues [active]
700598016507	substrate binding site [chemical binding]; other site
700598016508	CAAX protease self-immunity; Region: Abi; pfam02517
700598016509	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
700598016510	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
700598016511	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
700598016512	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
700598016513	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700598016514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598016515	motif II; other site
700598016516	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
700598016517	classical (c) SDRs; Region: SDR_c; cd05233
700598016518	NAD(P) binding site [chemical binding]; other site
700598016519	active site
700598016520	Oxygen tolerance; Region: BatD; pfam13584
700598016521	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598016522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598016523	active site
700598016524	phosphorylation site [posttranslational modification]
700598016525	intermolecular recognition site; other site
700598016526	dimerization interface [polypeptide binding]; other site
700598016527	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598016528	DNA binding site [nucleotide binding]
700598016529	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598016530	dimer interface [polypeptide binding]; other site
700598016531	phosphorylation site [posttranslational modification]
700598016532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598016533	ATP binding site [chemical binding]; other site
700598016534	Mg2+ binding site [ion binding]; other site
700598016535	G-X-G motif; other site
700598016536	GldH lipoprotein; Region: GldH_lipo; pfam14109
700598016537	hypothetical protein; Provisional; Region: PRK11820
700598016538	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
700598016539	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
700598016540	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
700598016541	pseudouridine synthase; Region: TIGR00093
700598016542	active site
700598016543	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
700598016544	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
700598016545	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
700598016546	trimer interface [polypeptide binding]; other site
700598016547	active site
700598016548	UDP-GlcNAc binding site [chemical binding]; other site
700598016549	lipid binding site [chemical binding]; lipid-binding site
700598016550	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598016551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598016552	active site
700598016553	phosphorylation site [posttranslational modification]
700598016554	intermolecular recognition site; other site
700598016555	dimerization interface [polypeptide binding]; other site
700598016556	LytTr DNA-binding domain; Region: LytTR; smart00850
700598016557	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598016558	Histidine kinase; Region: His_kinase; pfam06580
700598016559	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598016560	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
700598016561	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
700598016562	putative NADP binding site [chemical binding]; other site
700598016563	putative substrate binding site [chemical binding]; other site
700598016564	active site
700598016565	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
700598016566	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
700598016567	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
700598016568	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
700598016569	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
700598016570	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
700598016571	dimer interface [polypeptide binding]; other site
700598016572	motif 1; other site
700598016573	active site
700598016574	motif 2; other site
700598016575	motif 3; other site
700598016576	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
700598016577	putative active site [active]
700598016578	putative metal binding site [ion binding]; other site
700598016579	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
700598016580	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
700598016581	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598016582	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598016583	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598016584	DNA binding residues [nucleotide binding]
700598016585	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598016586	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
700598016587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598016588	ATP binding site [chemical binding]; other site
700598016589	Mg2+ binding site [ion binding]; other site
700598016590	G-X-G motif; other site
700598016591	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
700598016592	ATP binding site [chemical binding]; other site
700598016593	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
700598016594	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
700598016595	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
700598016596	Beta-lactamase; Region: Beta-lactamase; cl17358
700598016597	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598016598	DinB superfamily; Region: DinB_2; pfam12867
700598016599	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
700598016600	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
700598016601	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
700598016602	dimer interface [polypeptide binding]; other site
700598016603	PYR/PP interface [polypeptide binding]; other site
700598016604	TPP binding site [chemical binding]; other site
700598016605	substrate binding site [chemical binding]; other site
700598016606	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
700598016607	cyclase homology domain; Region: CHD; cd07302
700598016608	nucleotidyl binding site; other site
700598016609	metal binding site [ion binding]; metal-binding site
700598016610	dimer interface [polypeptide binding]; other site
700598016611	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700598016612	Zn2+ binding site [ion binding]; other site
700598016613	Mg2+ binding site [ion binding]; other site
700598016614	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598016615	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598016616	active site
700598016617	metal binding site [ion binding]; metal-binding site
700598016618	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598016619	SdiA-regulated; Region: SdiA-regulated; cd09971
700598016620	putative active site [active]
700598016621	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
700598016622	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700598016623	minor groove reading motif; other site
700598016624	helix-hairpin-helix signature motif; other site
700598016625	active site
700598016626	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
700598016627	Septum formation initiator; Region: DivIC; cl17659
700598016628	enolase; Provisional; Region: eno; PRK00077
700598016629	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
700598016630	dimer interface [polypeptide binding]; other site
700598016631	metal binding site [ion binding]; metal-binding site
700598016632	substrate binding pocket [chemical binding]; other site
700598016633	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
700598016634	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
700598016635	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700598016636	Walker A/P-loop; other site
700598016637	ATP binding site [chemical binding]; other site
700598016638	Q-loop/lid; other site
700598016639	ABC transporter signature motif; other site
700598016640	Walker B; other site
700598016641	D-loop; other site
700598016642	H-loop/switch region; other site
700598016643	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
700598016644	active site clefts [active]
700598016645	zinc binding site [ion binding]; other site
700598016646	dimer interface [polypeptide binding]; other site
700598016647	high affinity sulphate transporter 1; Region: sulP; TIGR00815
700598016648	Sulfate transporter family; Region: Sulfate_transp; pfam00916
700598016649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598016650	putative substrate translocation pore; other site
700598016651	acetyl-CoA synthetase; Provisional; Region: PRK00174
700598016652	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
700598016653	active site
700598016654	CoA binding site [chemical binding]; other site
700598016655	acyl-activating enzyme (AAE) consensus motif; other site
700598016656	AMP binding site [chemical binding]; other site
700598016657	acetate binding site [chemical binding]; other site
700598016658	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598016659	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700598016660	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
700598016661	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
700598016662	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598016663	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598016664	DNA binding residues [nucleotide binding]
700598016665	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
700598016666	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
700598016667	substrate-cofactor binding pocket; other site
700598016668	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598016669	catalytic residue [active]
700598016670	TPR repeat; Region: TPR_11; pfam13414
700598016671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598016672	binding surface
700598016673	TPR motif; other site
700598016674	TPR repeat; Region: TPR_11; pfam13414
700598016675	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
700598016676	active site
700598016677	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
700598016678	homotrimer interaction site [polypeptide binding]; other site
700598016679	putative active site [active]
700598016680	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
700598016681	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
700598016682	Glycoprotease family; Region: Peptidase_M22; pfam00814
700598016683	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598016684	dimerization interface [polypeptide binding]; other site
700598016685	putative DNA binding site [nucleotide binding]; other site
700598016686	putative Zn2+ binding site [ion binding]; other site
700598016687	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
700598016688	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700598016689	active site residue [active]
700598016690	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700598016691	active site residue [active]
700598016692	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598016693	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598016694	active site
700598016695	phosphorylation site [posttranslational modification]
700598016696	intermolecular recognition site; other site
700598016697	dimerization interface [polypeptide binding]; other site
700598016698	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598016699	DNA binding residues [nucleotide binding]
700598016700	dimerization interface [polypeptide binding]; other site
700598016701	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
700598016702	putative acyl-acceptor binding pocket; other site
700598016703	Phosphotransferase enzyme family; Region: APH; pfam01636
700598016704	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
700598016705	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
700598016706	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
700598016707	Pleckstrin homology-like domain; Region: PH-like; cl17171
700598016708	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
700598016709	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
700598016710	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
700598016711	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
700598016712	Substrate binding site; other site
700598016713	metal-binding site
700598016714	L-aspartate oxidase; Provisional; Region: PRK09077
700598016715	L-aspartate oxidase; Provisional; Region: PRK06175
700598016716	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
700598016717	SPRY-associated domain; Region: PRY; cl02686
700598016718	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
700598016719	active site
700598016720	catalytic residues [active]
700598016721	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
700598016722	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
700598016723	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
700598016724	DinB family; Region: DinB; cl17821
700598016725	DinB superfamily; Region: DinB_2; pfam12867
700598016726	Predicted transcriptional regulator [Transcription]; Region: COG2378
700598016727	HTH domain; Region: HTH_11; pfam08279
700598016728	WYL domain; Region: WYL; pfam13280
700598016729	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
700598016730	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
700598016731	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
700598016732	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598016733	binding surface
700598016734	TPR motif; other site
700598016735	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
700598016736	von Willebrand factor type A domain; Region: VWA_2; pfam13519
700598016737	metal ion-dependent adhesion site (MIDAS); other site
700598016738	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
700598016739	Trehalase; Region: Trehalase; cl17346
700598016740	trehalase; Provisional; Region: treF; PRK13270
700598016741	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
700598016742	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
700598016743	active site
700598016744	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
700598016745	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700598016746	active site
700598016747	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
700598016748	active site
700598016749	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
700598016750	classical (c) SDRs; Region: SDR_c; cd05233
700598016751	NAD(P) binding site [chemical binding]; other site
700598016752	active site
700598016753	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
700598016754	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598016755	putative substrate translocation pore; other site
700598016756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598016757	short chain dehydrogenase; Provisional; Region: PRK08628
700598016758	classical (c) SDRs; Region: SDR_c; cd05233
700598016759	NAD(P) binding site [chemical binding]; other site
700598016760	active site
700598016761	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
700598016762	Amidohydrolase; Region: Amidohydro_2; pfam04909
700598016763	Domain of unknown function (DUF718); Region: DUF718; pfam05336
700598016764	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
700598016765	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
700598016766	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
700598016767	B12 binding site [chemical binding]; other site
700598016768	cobalt ligand [ion binding]; other site
700598016769	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
700598016770	putative active site [active]
700598016771	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
700598016772	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700598016773	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
700598016774	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
700598016775	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
700598016776	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598016777	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700598016778	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598016779	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700598016780	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700598016781	Walker A/P-loop; other site
700598016782	ATP binding site [chemical binding]; other site
700598016783	Q-loop/lid; other site
700598016784	ABC transporter signature motif; other site
700598016785	Walker B; other site
700598016786	D-loop; other site
700598016787	H-loop/switch region; other site
700598016788	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598016789	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598016790	FtsX-like permease family; Region: FtsX; pfam02687
700598016791	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
700598016792	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
700598016793	DNA binding site [nucleotide binding]
700598016794	catalytic residue [active]
700598016795	H2TH interface [polypeptide binding]; other site
700598016796	putative catalytic residues [active]
700598016797	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
700598016798	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
700598016799	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
700598016800	ATP binding site [chemical binding]; other site
700598016801	Mg++ binding site [ion binding]; other site
700598016802	motif III; other site
700598016803	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598016804	nucleotide binding region [chemical binding]; other site
700598016805	ATP-binding site [chemical binding]; other site
700598016806	Protein of unknown function (DUF763); Region: DUF763; pfam05559
700598016807	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598016808	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598016809	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598016810	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
700598016811	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
700598016812	amidase catalytic site [active]
700598016813	Zn binding residues [ion binding]; other site
700598016814	substrate binding site [chemical binding]; other site
700598016815	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
700598016816	dimer interface [polypeptide binding]; other site
700598016817	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
700598016818	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598016819	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598016820	DNA binding residues [nucleotide binding]
700598016821	Protein of unknown function DUF72; Region: DUF72; pfam01904
700598016822	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
700598016823	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
700598016824	active site
700598016825	DNA binding site [nucleotide binding]
700598016826	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
700598016827	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
700598016828	Catalytic site [active]
700598016829	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
700598016830	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
700598016831	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
700598016832	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598016833	FeS/SAM binding site; other site
700598016834	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
700598016835	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700598016836	Histidine kinase; Region: HisKA_3; pfam07730
700598016837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598016838	ATP binding site [chemical binding]; other site
700598016839	Mg2+ binding site [ion binding]; other site
700598016840	G-X-G motif; other site
700598016841	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700598016842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598016843	active site
700598016844	phosphorylation site [posttranslational modification]
700598016845	intermolecular recognition site; other site
700598016846	dimerization interface [polypeptide binding]; other site
700598016847	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700598016848	DNA binding residues [nucleotide binding]
700598016849	dimerization interface [polypeptide binding]; other site
700598016850	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700598016851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
700598016852	Walker A motif; other site
700598016853	ATP binding site [chemical binding]; other site
700598016854	Walker B motif; other site
700598016855	arginine finger; other site
700598016856	Protein of unknown function (DUF458); Region: DUF458; cl00861
700598016857	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
700598016858	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
700598016859	DinB superfamily; Region: DinB_2; pfam12867
700598016860	hypothetical protein; Reviewed; Region: PRK09588
700598016861	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
700598016862	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598016863	active site
700598016864	metal binding site [ion binding]; metal-binding site
700598016865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
700598016866	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
700598016867	transcriptional activator RfaH; Region: RfaH; TIGR01955
700598016868	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
700598016869	SLBB domain; Region: SLBB; pfam10531
700598016870	Chain length determinant protein; Region: Wzz; cl15801
700598016871	tyrosine kinase; Provisional; Region: PRK11519
700598016872	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700598016873	putative trimer interface [polypeptide binding]; other site
700598016874	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
700598016875	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
700598016876	putative CoA binding site [chemical binding]; other site
700598016877	putative trimer interface [polypeptide binding]; other site
700598016878	putative active site [active]
700598016879	putative substrate binding site [chemical binding]; other site
700598016880	putative CoA binding site [chemical binding]; other site
700598016881	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598016882	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598016883	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700598016884	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
700598016885	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
700598016886	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
700598016887	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
700598016888	Walker A/P-loop; other site
700598016889	ATP binding site [chemical binding]; other site
700598016890	Q-loop/lid; other site
700598016891	ABC transporter signature motif; other site
700598016892	Walker B; other site
700598016893	D-loop; other site
700598016894	H-loop/switch region; other site
700598016895	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
700598016896	putative carbohydrate binding site [chemical binding]; other site
700598016897	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
700598016898	trimer interface [polypeptide binding]; other site
700598016899	active site
700598016900	substrate binding site [chemical binding]; other site
700598016901	CoA binding site [chemical binding]; other site
700598016902	Methyltransferase domain; Region: Methyltransf_24; pfam13578
700598016903	WxcM-like, C-terminal; Region: FdtA; pfam05523
700598016904	WxcM-like, C-terminal; Region: FdtA; pfam05523
700598016905	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
700598016906	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598016907	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598016908	NAD(P) binding site [chemical binding]; other site
700598016909	active site
700598016910	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
700598016911	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700598016912	active site
700598016913	motif I; other site
700598016914	motif II; other site
700598016915	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
700598016916	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
700598016917	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
700598016918	trimer interface [polypeptide binding]; other site
700598016919	active site
700598016920	substrate binding site [chemical binding]; other site
700598016921	CoA binding site [chemical binding]; other site
700598016922	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
700598016923	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
700598016924	inhibitor-cofactor binding pocket; inhibition site
700598016925	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598016926	catalytic residue [active]
700598016927	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700598016928	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
700598016929	active site
700598016930	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700598016931	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598016932	S-adenosylmethionine binding site [chemical binding]; other site
700598016933	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
700598016934	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
700598016935	NAD(P) binding site [chemical binding]; other site
700598016936	homodimer interface [polypeptide binding]; other site
700598016937	substrate binding site [chemical binding]; other site
700598016938	active site
700598016939	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598016940	NAD(P) binding site [chemical binding]; other site
700598016941	active site
700598016942	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
700598016943	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598016944	active site
700598016945	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598016946	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598016947	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598016948	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598016949	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
700598016950	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598016951	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598016952	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
700598016953	active site
700598016954	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
700598016955	homodimer interface [polypeptide binding]; other site
700598016956	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
700598016957	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598016958	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598016959	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
700598016960	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598016961	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
700598016962	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598016963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598016964	NAD(P) binding site [chemical binding]; other site
700598016965	active site
700598016966	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598016967	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598016968	active site
700598016969	catalytic tetrad [active]
700598016970	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
700598016971	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598016972	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700598016973	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598016974	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598016975	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
700598016976	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
700598016977	NADP-binding site; other site
700598016978	homotetramer interface [polypeptide binding]; other site
700598016979	substrate binding site [chemical binding]; other site
700598016980	homodimer interface [polypeptide binding]; other site
700598016981	active site
700598016982	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
700598016983	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598016984	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598016985	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598016986	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
700598016987	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
700598016988	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
700598016989	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
700598016990	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
700598016991	metal-binding site
700598016992	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
700598016993	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
700598016994	NADP-binding site; other site
700598016995	homotetramer interface [polypeptide binding]; other site
700598016996	substrate binding site [chemical binding]; other site
700598016997	homodimer interface [polypeptide binding]; other site
700598016998	active site
700598016999	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
700598017000	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
700598017001	NADP binding site [chemical binding]; other site
700598017002	active site
700598017003	putative substrate binding site [chemical binding]; other site
700598017004	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
700598017005	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
700598017006	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700598017007	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
700598017008	DNA binding residues [nucleotide binding]
700598017009	B12 binding domain; Region: B12-binding_2; pfam02607
700598017010	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
700598017011	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598017012	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598017013	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598017014	DNA binding residues [nucleotide binding]
700598017015	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
700598017016	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
700598017017	active site
700598017018	metal binding site [ion binding]; metal-binding site
700598017019	nudix motif; other site
700598017020	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700598017021	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700598017022	non-specific DNA binding site [nucleotide binding]; other site
700598017023	salt bridge; other site
700598017024	sequence-specific DNA binding site [nucleotide binding]; other site
700598017025	MG2 domain; Region: A2M_N; pfam01835
700598017026	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
700598017027	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598017028	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598017029	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598017030	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
700598017031	putative active site [active]
700598017032	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
700598017033	FAD binding domain; Region: FAD_binding_4; pfam01565
700598017034	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
700598017035	Histidine kinase; Region: His_kinase; pfam06580
700598017036	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598017037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598017038	active site
700598017039	phosphorylation site [posttranslational modification]
700598017040	intermolecular recognition site; other site
700598017041	dimerization interface [polypeptide binding]; other site
700598017042	LytTr DNA-binding domain; Region: LytTR; smart00850
700598017043	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598017044	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598017045	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598017046	putative substrate translocation pore; other site
700598017047	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
700598017048	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700598017049	putative DNA binding site [nucleotide binding]; other site
700598017050	putative Zn2+ binding site [ion binding]; other site
700598017051	AsnC family; Region: AsnC_trans_reg; pfam01037
700598017052	IPT/TIG domain; Region: TIG; pfam01833
700598017053	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
700598017054	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598017055	short chain dehydrogenase; Provisional; Region: PRK06180
700598017056	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598017057	NADP binding site [chemical binding]; other site
700598017058	active site
700598017059	steroid binding site; other site
700598017060	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700598017061	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598017062	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598017063	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598017064	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598017065	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
700598017066	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
700598017067	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
700598017068	DNA binding residues [nucleotide binding]
700598017069	dimerization interface [polypeptide binding]; other site
700598017070	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
700598017071	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
700598017072	putative metal binding site [ion binding]; other site
700598017073	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
700598017074	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
700598017075	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
700598017076	Penicillinase repressor; Region: Pencillinase_R; pfam03965
700598017077	Domain of unknown function (DUF4291); Region: DUF4291; pfam14124
700598017078	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
700598017079	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700598017080	PA14 domain; Region: PA14; cl08459
700598017081	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700598017082	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700598017083	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598017084	NAD(P) binding site [chemical binding]; other site
700598017085	active site
700598017086	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598017087	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598017088	ligand binding site [chemical binding]; other site
700598017089	flexible hinge region; other site
700598017090	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
700598017091	YceI-like domain; Region: YceI; pfam04264
700598017092	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
700598017093	active site 1 [active]
700598017094	dimer interface [polypeptide binding]; other site
700598017095	hexamer interface [polypeptide binding]; other site
700598017096	active site 2 [active]
700598017097	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
700598017098	classical (c) SDRs; Region: SDR_c; cd05233
700598017099	NAD(P) binding site [chemical binding]; other site
700598017100	active site
700598017101	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
700598017102	Nitronate monooxygenase; Region: NMO; pfam03060
700598017103	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
700598017104	FMN binding site [chemical binding]; other site
700598017105	substrate binding site [chemical binding]; other site
700598017106	putative catalytic residue [active]
700598017107	short chain dehydrogenase; Provisional; Region: PRK06180
700598017108	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700598017109	NADP binding site [chemical binding]; other site
700598017110	active site
700598017111	steroid binding site; other site
700598017112	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
700598017113	Protein of unknown function, DUF481; Region: DUF481; cl01213
700598017114	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598017115	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700598017116	active site
700598017117	metal binding site [ion binding]; metal-binding site
700598017118	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
700598017119	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
700598017120	Protein of unknown function (DUF433); Region: DUF433; cl01030
700598017121	Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743
700598017122	dimer interface [polypeptide binding]; other site
700598017123	Histidine kinase; Region: His_kinase; pfam06580
700598017124	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700598017125	catalytic core [active]
700598017126	cobalamin synthase; Reviewed; Region: cobS; PRK00235
700598017127	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
700598017128	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
700598017129	putative dimer interface [polypeptide binding]; other site
700598017130	active site pocket [active]
700598017131	putative cataytic base [active]
700598017132	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
700598017133	Ligand Binding Site [chemical binding]; other site
700598017134	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
700598017135	homotrimer interface [polypeptide binding]; other site
700598017136	Walker A motif; other site
700598017137	GTP binding site [chemical binding]; other site
700598017138	Walker B motif; other site
700598017139	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
700598017140	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
700598017141	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
700598017142	intersubunit interface [polypeptide binding]; other site
700598017143	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598017144	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
700598017145	N-terminal plug; other site
700598017146	ligand-binding site [chemical binding]; other site
700598017147	amino acid transporter; Region: 2A0306; TIGR00909
700598017148	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
700598017149	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
700598017150	homodimer interface [polypeptide binding]; other site
700598017151	substrate-cofactor binding pocket; other site
700598017152	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598017153	catalytic residue [active]
700598017154	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
700598017155	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598017156	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700598017157	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598017158	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
700598017159	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
700598017160	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
700598017161	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
700598017162	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598017163	FeS/SAM binding site; other site
700598017164	HemN C-terminal domain; Region: HemN_C; pfam06969
700598017165	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598017166	Domain of unknown function (DUF4271); Region: DUF4271; pfam14093
700598017167	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
700598017168	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
700598017169	active site
700598017170	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
700598017171	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
700598017172	catalytic residues [active]
700598017173	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
700598017174	gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525
700598017175	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
700598017176	gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513
700598017177	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
700598017178	GldM N-terminal domain; Region: GldM_N; pfam12081
700598017179	GldM C-terminal domain; Region: GldM_C; pfam12080
700598017180	gliding motility associated protien GldN; Region: GldN; TIGR03523
700598017181	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
700598017182	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
700598017183	GIY-YIG motif/motif A; other site
700598017184	active site
700598017185	catalytic site [active]
700598017186	putative DNA binding site [nucleotide binding]; other site
700598017187	metal binding site [ion binding]; metal-binding site
700598017188	UvrB/uvrC motif; Region: UVR; pfam02151
700598017189	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
700598017190	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598017191	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598017192	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598017193	DNA binding residues [nucleotide binding]
700598017194	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
700598017195	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
700598017196	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
700598017197	phosphoglyceromutase; Provisional; Region: PRK05434
700598017198	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
700598017199	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
700598017200	dimerization interface [polypeptide binding]; other site
700598017201	active site
700598017202	translation initiation factor Sui1; Validated; Region: PRK06824
700598017203	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
700598017204	putative rRNA binding site [nucleotide binding]; other site
700598017205	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
700598017206	isocitrate dehydrogenase; Validated; Region: PRK09222
700598017207	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
700598017208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598017209	putative substrate translocation pore; other site
700598017210	POT family; Region: PTR2; cl17359
700598017211	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
700598017212	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
700598017213	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
700598017214	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
700598017215	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
700598017216	rod shape-determining protein MreB; Provisional; Region: PRK13927
700598017217	MreB and similar proteins; Region: MreB_like; cd10225
700598017218	nucleotide binding site [chemical binding]; other site
700598017219	Mg binding site [ion binding]; other site
700598017220	putative protofilament interaction site [polypeptide binding]; other site
700598017221	RodZ interaction site [polypeptide binding]; other site
700598017222	rod shape-determining protein MreC; Provisional; Region: PRK13922
700598017223	rod shape-determining protein MreC; Region: MreC; pfam04085
700598017224	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
700598017225	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
700598017226	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700598017227	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
700598017228	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700598017229	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598017230	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598017231	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598017232	DNA binding residues [nucleotide binding]
700598017233	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
700598017234	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700598017235	PYR/PP interface [polypeptide binding]; other site
700598017236	dimer interface [polypeptide binding]; other site
700598017237	TPP binding site [chemical binding]; other site
700598017238	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700598017239	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
700598017240	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
700598017241	NAD binding site [chemical binding]; other site
700598017242	homodimer interface [polypeptide binding]; other site
700598017243	active site
700598017244	substrate binding site [chemical binding]; other site
700598017245	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
700598017246	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
700598017247	substrate binding site; other site
700598017248	tetramer interface; other site
700598017249	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
700598017250	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
700598017251	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598017252	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598017253	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598017254	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
700598017255	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598017256	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
700598017257	putative active site [active]
700598017258	putative metal binding site [ion binding]; other site
700598017259	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598017260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598017261	dimer interface [polypeptide binding]; other site
700598017262	phosphorylation site [posttranslational modification]
700598017263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598017264	ATP binding site [chemical binding]; other site
700598017265	Mg2+ binding site [ion binding]; other site
700598017266	G-X-G motif; other site
700598017267	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598017268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598017269	active site
700598017270	phosphorylation site [posttranslational modification]
700598017271	intermolecular recognition site; other site
700598017272	dimerization interface [polypeptide binding]; other site
700598017273	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598017274	DNA binding site [nucleotide binding]
700598017275	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700598017276	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598017277	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
700598017278	Walker A/P-loop; other site
700598017279	ATP binding site [chemical binding]; other site
700598017280	Q-loop/lid; other site
700598017281	ABC transporter signature motif; other site
700598017282	Walker B; other site
700598017283	D-loop; other site
700598017284	H-loop/switch region; other site
700598017285	ATP synthase A chain; Region: ATP-synt_A; cl00413
700598017286	ATP synthase subunit C; Region: ATP-synt_C; cl00466
700598017287	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
700598017288	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
700598017289	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
700598017290	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
700598017291	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
700598017292	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
700598017293	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
700598017294	beta subunit interaction interface [polypeptide binding]; other site
700598017295	Walker A motif; other site
700598017296	ATP binding site [chemical binding]; other site
700598017297	Walker B motif; other site
700598017298	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
700598017299	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598017300	Domain of unknown function DUF11; Region: DUF11; cl17728
700598017301	Domain of unknown function DUF11; Region: DUF11; cl17728
700598017302	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598017303	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598017304	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598017305	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598017306	2TM domain; Region: 2TM; pfam13239
700598017307	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700598017308	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
700598017309	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700598017310	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
700598017311	Walker A/P-loop; other site
700598017312	ATP binding site [chemical binding]; other site
700598017313	Q-loop/lid; other site
700598017314	ABC transporter signature motif; other site
700598017315	Walker B; other site
700598017316	D-loop; other site
700598017317	H-loop/switch region; other site
700598017318	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
700598017319	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
700598017320	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700598017321	dimerization interface [polypeptide binding]; other site
700598017322	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700598017323	putative active site [active]
700598017324	heme pocket [chemical binding]; other site
700598017325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598017326	dimer interface [polypeptide binding]; other site
700598017327	phosphorylation site [posttranslational modification]
700598017328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598017329	ATP binding site [chemical binding]; other site
700598017330	Mg2+ binding site [ion binding]; other site
700598017331	G-X-G motif; other site
700598017332	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598017333	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598017334	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
700598017335	Uncharacterized conserved protein [Function unknown]; Region: COG1262
700598017336	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
700598017337	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
700598017338	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
700598017339	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
700598017340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598017341	S-adenosylmethionine binding site [chemical binding]; other site
700598017342	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
700598017343	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
700598017344	NAD binding site [chemical binding]; other site
700598017345	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
700598017346	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
700598017347	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
700598017348	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
700598017349	nucleotide binding site/active site [active]
700598017350	HIT family signature motif; other site
700598017351	catalytic residue [active]
700598017352	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
700598017353	active site
700598017354	putative DNA-binding cleft [nucleotide binding]; other site
700598017355	dimer interface [polypeptide binding]; other site
700598017356	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
700598017357	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
700598017358	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
700598017359	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
700598017360	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598017361	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
700598017362	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
700598017363	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
700598017364	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
700598017365	FtsX-like permease family; Region: FtsX; pfam02687
700598017366	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598017367	active site
700598017368	HIGH motif; other site
700598017369	nucleotide binding site [chemical binding]; other site
700598017370	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
700598017371	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598017372	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
700598017373	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598017374	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700598017375	active site
700598017376	KMSKS motif; other site
700598017377	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
700598017378	tRNA binding surface [nucleotide binding]; other site
700598017379	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
700598017380	Ubiquitin-like proteins; Region: UBQ; cl00155
700598017381	Peptidase family M23; Region: Peptidase_M23; pfam01551
700598017382	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
700598017383	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
700598017384	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
700598017385	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
700598017386	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598017387	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598017388	Walker A motif; other site
700598017389	Walker A/P-loop; other site
700598017390	ATP binding site [chemical binding]; other site
700598017391	ATP binding site [chemical binding]; other site
700598017392	Walker B motif; other site
700598017393	arginine finger; other site
700598017394	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
700598017395	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598017396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598017397	active site
700598017398	phosphorylation site [posttranslational modification]
700598017399	intermolecular recognition site; other site
700598017400	dimerization interface [polypeptide binding]; other site
700598017401	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598017402	DNA binding site [nucleotide binding]
700598017403	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
700598017404	oligomerisation interface [polypeptide binding]; other site
700598017405	mobile loop; other site
700598017406	roof hairpin; other site
700598017407	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
700598017408	Zonular occludens toxin (Zot); Region: Zot; cl17485
700598017409	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700598017410	DEAD-like helicases superfamily; Region: DEXDc; smart00487
700598017411	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598017412	ATP binding site [chemical binding]; other site
700598017413	putative Mg++ binding site [ion binding]; other site
700598017414	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598017415	nucleotide binding region [chemical binding]; other site
700598017416	ATP-binding site [chemical binding]; other site
700598017417	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
700598017418	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
700598017419	metal-binding site [ion binding]
700598017420	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700598017421	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700598017422	AAA domain; Region: AAA_23; pfam13476
700598017423	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
700598017424	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
700598017425	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
700598017426	hexamer interface [polypeptide binding]; other site
700598017427	ligand binding site [chemical binding]; other site
700598017428	putative active site [active]
700598017429	NAD(P) binding site [chemical binding]; other site
700598017430	diphthamide biosynthesis enzyme Dph1/Dph2 domain; Region: diphth2_R; cl15477
700598017431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598017432	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
700598017433	Walker A/P-loop; other site
700598017434	ATP binding site [chemical binding]; other site
700598017435	Q-loop/lid; other site
700598017436	ABC transporter signature motif; other site
700598017437	Walker B; other site
700598017438	D-loop; other site
700598017439	H-loop/switch region; other site
700598017440	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
700598017441	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
700598017442	active site
700598017443	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
700598017444	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
700598017445	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
700598017446	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
700598017447	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
700598017448	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
700598017449	trimer interface [polypeptide binding]; other site
700598017450	active site
700598017451	UDP-GlcNAc binding site [chemical binding]; other site
700598017452	lipid binding site [chemical binding]; lipid-binding site
700598017453	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
700598017454	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700598017455	Zn2+ binding site [ion binding]; other site
700598017456	Mg2+ binding site [ion binding]; other site
700598017457	Response regulator receiver domain; Region: Response_reg; pfam00072
700598017458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598017459	active site
700598017460	phosphorylation site [posttranslational modification]
700598017461	intermolecular recognition site; other site
700598017462	dimerization interface [polypeptide binding]; other site
700598017463	PglZ domain; Region: PglZ; pfam08665
700598017464	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
700598017465	putative hydrolase; Provisional; Region: PRK02113
700598017466	Response regulator receiver domain; Region: Response_reg; pfam00072
700598017467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598017468	active site
700598017469	phosphorylation site [posttranslational modification]
700598017470	intermolecular recognition site; other site
700598017471	dimerization interface [polypeptide binding]; other site
700598017472	FIST N domain; Region: FIST; pfam08495
700598017473	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
700598017474	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
700598017475	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
700598017476	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700598017477	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
700598017478	FAD binding site [chemical binding]; other site
700598017479	homotetramer interface [polypeptide binding]; other site
700598017480	substrate binding pocket [chemical binding]; other site
700598017481	catalytic base [active]
700598017482	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
700598017483	Cytochrome c; Region: Cytochrom_C; pfam00034
700598017484	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
700598017485	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
700598017486	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598017487	Walker A motif; other site
700598017488	ATP binding site [chemical binding]; other site
700598017489	Walker B motif; other site
700598017490	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
700598017491	Clp protease; Region: CLP_protease; pfam00574
700598017492	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
700598017493	oligomer interface [polypeptide binding]; other site
700598017494	active site residues [active]
700598017495	Clp protease; Region: CLP_protease; pfam00574
700598017496	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
700598017497	oligomer interface [polypeptide binding]; other site
700598017498	active site residues [active]
700598017499	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
700598017500	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
700598017501	Active Sites [active]
700598017502	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
700598017503	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
700598017504	Active Sites [active]
700598017505	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
700598017506	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
700598017507	CysD dimerization site [polypeptide binding]; other site
700598017508	G1 box; other site
700598017509	putative GEF interaction site [polypeptide binding]; other site
700598017510	GTP/Mg2+ binding site [chemical binding]; other site
700598017511	Switch I region; other site
700598017512	G2 box; other site
700598017513	G3 box; other site
700598017514	Switch II region; other site
700598017515	G4 box; other site
700598017516	G5 box; other site
700598017517	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
700598017518	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
700598017519	serine O-acetyltransferase; Region: cysE; TIGR01172
700598017520	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
700598017521	trimer interface [polypeptide binding]; other site
700598017522	active site
700598017523	substrate binding site [chemical binding]; other site
700598017524	CoA binding site [chemical binding]; other site
700598017525	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
700598017526	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
700598017527	dimer interface [polypeptide binding]; other site
700598017528	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598017529	catalytic residue [active]
700598017530	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
700598017531	active site
700598017532	SAM binding site [chemical binding]; other site
700598017533	homodimer interface [polypeptide binding]; other site
700598017534	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
700598017535	Flavodoxin; Region: Flavodoxin_1; pfam00258
700598017536	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
700598017537	FAD binding pocket [chemical binding]; other site
700598017538	conserved FAD binding motif [chemical binding]; other site
700598017539	phosphate binding motif [ion binding]; other site
700598017540	beta-alpha-beta structure motif; other site
700598017541	NAD binding pocket [chemical binding]; other site
700598017542	sulfite reductase subunit beta; Provisional; Region: PRK13504
700598017543	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
700598017544	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
700598017545	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
700598017546	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
700598017547	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700598017548	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598017549	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598017550	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
700598017551	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598017552	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
700598017553	Interdomain contacts; other site
700598017554	Cytokine receptor motif; other site
700598017555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700598017556	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700598017557	putative substrate translocation pore; other site
700598017558	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
700598017559	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
700598017560	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
700598017561	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
700598017562	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
700598017563	homodimer interface [polypeptide binding]; other site
700598017564	substrate-cofactor binding pocket; other site
700598017565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598017566	catalytic residue [active]
700598017567	CHAD domain; Region: CHAD; pfam05235
700598017568	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
700598017569	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
700598017570	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700598017571	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700598017572	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
700598017573	gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530
700598017574	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
700598017575	active site
700598017576	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
700598017577	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
700598017578	homotrimer interaction site [polypeptide binding]; other site
700598017579	zinc binding site [ion binding]; other site
700598017580	CDP-binding sites; other site
700598017581	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
700598017582	trimer interface [polypeptide binding]; other site
700598017583	active site
700598017584	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
700598017585	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
700598017586	Peptidase family M23; Region: Peptidase_M23; pfam01551
700598017587	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
700598017588	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
700598017589	Peptidase family M23; Region: Peptidase_M23; pfam01551
700598017590	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
700598017591	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
700598017592	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700598017593	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
700598017594	PA/protease or protease-like domain interface [polypeptide binding]; other site
700598017595	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
700598017596	metal binding site [ion binding]; metal-binding site
700598017597	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
700598017598	putative SAM binding site [chemical binding]; other site
700598017599	homodimer interface [polypeptide binding]; other site
700598017600	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
700598017601	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
700598017602	active site
700598017603	DNA binding site [nucleotide binding]
700598017604	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
700598017605	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700598017606	active site
700598017607	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
700598017608	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700598017609	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
700598017610	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700598017611	Peptidase family M28; Region: Peptidase_M28; pfam04389
700598017612	metal binding site [ion binding]; metal-binding site
700598017613	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598017614	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
700598017615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598017616	active site
700598017617	phosphorylation site [posttranslational modification]
700598017618	intermolecular recognition site; other site
700598017619	dimerization interface [polypeptide binding]; other site
700598017620	LytTr DNA-binding domain; Region: LytTR; smart00850
700598017621	Histidine kinase; Region: His_kinase; pfam06580
700598017622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598017623	ATP binding site [chemical binding]; other site
700598017624	Mg2+ binding site [ion binding]; other site
700598017625	G-X-G motif; other site
700598017626	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
700598017627	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
700598017628	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598017629	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700598017630	ligand binding site [chemical binding]; other site
700598017631	flexible hinge region; other site
700598017632	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
700598017633	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700598017634	DNA binding residues [nucleotide binding]
700598017635	B12 binding domain; Region: B12-binding_2; pfam02607
700598017636	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
700598017637	phytoene desaturase; Region: crtI_fam; TIGR02734
700598017638	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700598017639	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
700598017640	active site lid residues [active]
700598017641	substrate binding pocket [chemical binding]; other site
700598017642	catalytic residues [active]
700598017643	substrate-Mg2+ binding site; other site
700598017644	aspartate-rich region 1; other site
700598017645	aspartate-rich region 2; other site
700598017646	beta-carotene hydroxylase; Region: PLN02601
700598017647	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
700598017648	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
700598017649	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
700598017650	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598017651	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
700598017652	active site
700598017653	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
700598017654	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
700598017655	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
700598017656	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
700598017657	active site
700598017658	catalytic site [active]
700598017659	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
700598017660	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700598017661	RNA binding surface [nucleotide binding]; other site
700598017662	hypothetical protein; Provisional; Region: PRK08201
700598017663	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
700598017664	metal binding site [ion binding]; metal-binding site
700598017665	putative dimer interface [polypeptide binding]; other site
700598017666	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
700598017667	Cation efflux family; Region: Cation_efflux; pfam01545
700598017668	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
700598017669	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
700598017670	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
700598017671	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
700598017672	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598017673	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
700598017674	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
700598017675	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598017676	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598017677	DNA binding residues [nucleotide binding]
700598017678	signal recognition particle protein; Provisional; Region: PRK10867
700598017679	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
700598017680	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
700598017681	P loop; other site
700598017682	GTP binding site [chemical binding]; other site
700598017683	Signal peptide binding domain; Region: SRP_SPB; pfam02978
700598017684	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
700598017685	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
700598017686	RimM N-terminal domain; Region: RimM; pfam01782
700598017687	DinB superfamily; Region: DinB_2; pfam12867
700598017688	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700598017689	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
700598017690	ligand binding site [chemical binding]; other site
700598017691	flexible hinge region; other site
700598017692	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
700598017693	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
700598017694	active site
700598017695	DNA binding site [nucleotide binding]
700598017696	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
700598017697	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
700598017698	dimer interface [polypeptide binding]; other site
700598017699	decamer (pentamer of dimers) interface [polypeptide binding]; other site
700598017700	catalytic triad [active]
700598017701	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
700598017702	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598017703	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
700598017704	active site
700598017705	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
700598017706	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
700598017707	active site
700598017708	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
700598017709	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700598017710	RNA binding surface [nucleotide binding]; other site
700598017711	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
700598017712	active site
700598017713	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
700598017714	dimer interface [polypeptide binding]; other site
700598017715	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
700598017716	dimer interface [polypeptide binding]; other site
700598017717	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
700598017718	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700598017719	FeS/SAM binding site; other site
700598017720	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
700598017721	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700598017722	dimer interface [polypeptide binding]; other site
700598017723	active site
700598017724	DinB superfamily; Region: DinB_2; pfam12867
700598017725	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598017726	Walker A/P-loop; other site
700598017727	ATP binding site [chemical binding]; other site
700598017728	ABC transporter; Region: ABC_tran; pfam00005
700598017729	Q-loop/lid; other site
700598017730	ABC transporter signature motif; other site
700598017731	Walker B; other site
700598017732	D-loop; other site
700598017733	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
700598017734	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
700598017735	dimer interface [polypeptide binding]; other site
700598017736	motif 1; other site
700598017737	active site
700598017738	motif 2; other site
700598017739	motif 3; other site
700598017740	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
700598017741	anticodon binding site; other site
700598017742	Low molecular weight phosphatase family; Region: LMWPc; cd00115
700598017743	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
700598017744	active site
700598017745	PBP superfamily domain; Region: PBP_like_2; pfam12849
700598017746	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598017747	binding surface
700598017748	Tetratricopeptide repeat; Region: TPR_16; pfam13432
700598017749	TPR motif; other site
700598017750	TPR repeat; Region: TPR_11; pfam13414
700598017751	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598017752	binding surface
700598017753	TPR motif; other site
700598017754	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
700598017755	NADH dehydrogenase subunit B; Provisional; Region: PRK14820
700598017756	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
700598017757	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
700598017758	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
700598017759	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
700598017760	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
700598017761	putative dimer interface [polypeptide binding]; other site
700598017762	[2Fe-2S] cluster binding site [ion binding]; other site
700598017763	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
700598017764	SLBB domain; Region: SLBB; pfam10531
700598017765	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
700598017766	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700598017767	catalytic loop [active]
700598017768	iron binding site [ion binding]; other site
700598017769	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
700598017770	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
700598017771	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
700598017772	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
700598017773	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
700598017774	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
700598017775	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
700598017776	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
700598017777	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
700598017778	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
700598017779	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700598017780	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
700598017781	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700598017782	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
700598017783	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700598017784	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700598017785	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700598017786	FtsX-like permease family; Region: FtsX; pfam02687
700598017787	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
700598017788	active site
700598017789	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
700598017790	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
700598017791	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
700598017792	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
700598017793	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
700598017794	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
700598017795	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
700598017796	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
700598017797	trmE is a tRNA modification GTPase; Region: trmE; cd04164
700598017798	G1 box; other site
700598017799	GTP/Mg2+ binding site [chemical binding]; other site
700598017800	Switch I region; other site
700598017801	G2 box; other site
700598017802	Switch II region; other site
700598017803	G3 box; other site
700598017804	G4 box; other site
700598017805	G5 box; other site
700598017806	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
700598017807	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598017808	Putative glucoamylase; Region: Glycoamylase; pfam10091
700598017809	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
700598017810	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
700598017811	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
700598017812	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
700598017813	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
700598017814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598017815	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598017816	dimer interface [polypeptide binding]; other site
700598017817	phosphorylation site [posttranslational modification]
700598017818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598017819	ATP binding site [chemical binding]; other site
700598017820	Mg2+ binding site [ion binding]; other site
700598017821	G-X-G motif; other site
700598017822	Response regulator receiver domain; Region: Response_reg; pfam00072
700598017823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598017824	active site
700598017825	phosphorylation site [posttranslational modification]
700598017826	intermolecular recognition site; other site
700598017827	dimerization interface [polypeptide binding]; other site
700598017828	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598017829	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598017830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598017831	TPR motif; other site
700598017832	binding surface
700598017833	TPR repeat; Region: TPR_11; pfam13414
700598017834	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598017835	binding surface
700598017836	TPR motif; other site
700598017837	TPR repeat; Region: TPR_11; pfam13414
700598017838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598017839	binding surface
700598017840	TPR repeat; Region: TPR_11; pfam13414
700598017841	TPR motif; other site
700598017842	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598017843	binding surface
700598017844	TPR motif; other site
700598017845	TPR repeat; Region: TPR_11; pfam13414
700598017846	TPR repeat; Region: TPR_11; pfam13414
700598017847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598017848	binding surface
700598017849	TPR motif; other site
700598017850	TPR repeat; Region: TPR_11; pfam13414
700598017851	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598017852	binding surface
700598017853	TPR motif; other site
700598017854	TPR repeat; Region: TPR_11; pfam13414
700598017855	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598017856	binding surface
700598017857	TPR motif; other site
700598017858	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700598017859	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700598017860	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700598017861	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
700598017862	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
700598017863	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
700598017864	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
700598017865	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
700598017866	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
700598017867	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598017868	NAD(P) binding site [chemical binding]; other site
700598017869	active site
700598017870	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
700598017871	Bacterial sugar transferase; Region: Bac_transf; pfam02397
700598017872	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
700598017873	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
700598017874	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
700598017875	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
700598017876	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817
700598017877	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598017878	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700598017879	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
700598017880	putative active site [active]
700598017881	putative metal binding site [ion binding]; other site
700598017882	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598017883	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598017884	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598017885	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598017886	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598017887	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598017888	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700598017889	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598017890	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
700598017891	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
700598017892	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700598017893	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
700598017894	putative NAD(P) binding site [chemical binding]; other site
700598017895	active site
700598017896	putative substrate binding site [chemical binding]; other site
700598017897	Chain length determinant protein; Region: Wzz; pfam02706
700598017898	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
700598017899	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
700598017900	AAA domain; Region: AAA_31; pfam13614
700598017901	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700598017902	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
700598017903	SLBB domain; Region: SLBB; pfam10531
700598017904	Transcription antiterminator [Transcription]; Region: NusG; COG0250
700598017905	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
700598017906	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
700598017907	heterodimer interface [polypeptide binding]; other site
700598017908	homodimer interface [polypeptide binding]; other site
700598017909	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
700598017910	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598017911	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
700598017912	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
700598017913	oligomer interface [polypeptide binding]; other site
700598017914	metal binding site [ion binding]; metal-binding site
700598017915	metal binding site [ion binding]; metal-binding site
700598017916	putative Cl binding site [ion binding]; other site
700598017917	basic sphincter; other site
700598017918	hydrophobic gate; other site
700598017919	periplasmic entrance; other site
700598017920	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700598017921	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700598017922	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598017923	Walker A/P-loop; other site
700598017924	ATP binding site [chemical binding]; other site
700598017925	Q-loop/lid; other site
700598017926	ABC transporter signature motif; other site
700598017927	Walker B; other site
700598017928	D-loop; other site
700598017929	H-loop/switch region; other site
700598017930	LytTr DNA-binding domain; Region: LytTR; smart00850
700598017931	MG2 domain; Region: A2M_N; pfam01835
700598017932	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598017933	Alpha-2-macroglobulin family; Region: A2M; pfam00207
700598017934	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
700598017935	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598017936	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598017937	BNR repeat-like domain; Region: BNR_2; pfam13088
700598017938	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
700598017939	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
700598017940	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
700598017941	putative active site [active]
700598017942	catalytic site [active]
700598017943	putative metal binding site [ion binding]; other site
700598017944	oligomer interface [polypeptide binding]; other site
700598017945	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598017946	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598017947	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
700598017948	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598017949	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598017950	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700598017951	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700598017952	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502
700598017953	active site
700598017954	catalytic triad [active]
700598017955	oxyanion hole [active]
700598017956	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
700598017957	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
700598017958	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700598017959	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700598017960	Walker A motif; other site
700598017961	ATP binding site [chemical binding]; other site
700598017962	Walker B motif; other site
700598017963	arginine finger; other site
700598017964	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
700598017965	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
700598017966	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
700598017967	Domain of unknown function DUF21; Region: DUF21; pfam01595
700598017968	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
700598017969	Transporter associated domain; Region: CorC_HlyC; smart01091
700598017970	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598017971	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598017972	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598017973	DNA binding residues [nucleotide binding]
700598017974	FecR protein; Region: FecR; pfam04773
700598017975	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
700598017976	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
700598017977	putative metal binding site [ion binding]; other site
700598017978	Peptidase family A21; Region: Peptidase_A21; pfam03566
700598017979	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598017980	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
700598017981	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598017982	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598017983	DNA binding residues [nucleotide binding]
700598017984	FecR protein; Region: FecR; pfam04773
700598017985	Secretin and TonB N terminus short domain; Region: STN; pfam07660
700598017986	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598017987	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598017988	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598017989	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598017990	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598017991	SusD family; Region: SusD; pfam07980
700598017992	IPT/TIG domain; Region: TIG; pfam01833
700598017993	IPT/TIG domain; Region: TIG; pfam01833
700598017994	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
700598017995	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
700598017996	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
700598017997	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700598017998	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700598017999	HlyD family secretion protein; Region: HlyD_3; pfam13437
700598018000	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
700598018001	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
700598018002	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
700598018003	Mechanosensitive ion channel; Region: MS_channel; pfam00924
700598018004	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
700598018005	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598018006	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
700598018007	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
700598018008	Fic/DOC family; Region: Fic; pfam02661
700598018009	Fic/DOC family; Region: Fic; pfam02661
700598018010	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
700598018011	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
700598018012	Uncharacterized conserved protein [Function unknown]; Region: COG4104
700598018013	Peptidase M35 family; Region: M35_like; cl03449
700598018014	active site
700598018015	Zn binding site [ion binding]; other site
700598018016	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700598018017	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
700598018018	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
700598018019	Sulfate transporter family; Region: Sulfate_transp; pfam00916
700598018020	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
700598018021	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598018022	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598018023	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598018024	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
700598018025	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598018026	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
700598018027	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598018028	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
700598018029	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700598018030	putative active site [active]
700598018031	putative metal binding site [ion binding]; other site
700598018032	Right handed beta helix region; Region: Beta_helix; pfam13229
700598018033	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598018034	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
700598018035	Virulence protein [General function prediction only]; Region: COG3943
700598018036	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
700598018037	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
700598018038	Mrr N-terminal domain; Region: Mrr_N; pfam14338
700598018039	Restriction endonuclease; Region: Mrr_cat; pfam04471
700598018040	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
700598018041	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
700598018042	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
700598018043	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
700598018044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700598018045	S-adenosylmethionine binding site [chemical binding]; other site
700598018046	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
700598018047	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
700598018048	active site
700598018049	metal binding site [ion binding]; metal-binding site
700598018050	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700598018051	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
700598018052	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598018053	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598018054	hypothetical protein; Provisional; Region: PRK11281
700598018055	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598018056	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
700598018057	Beta-lactamase; Region: Beta-lactamase; pfam00144
700598018058	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700598018059	Pleckstrin homology-like domain; Region: PH-like; cl17171
700598018060	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598018061	binding surface
700598018062	Tetratricopeptide repeat; Region: TPR_16; pfam13432
700598018063	TPR motif; other site
700598018064	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598018065	Helix-turn-helix domain; Region: HTH_18; pfam12833
700598018066	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
700598018067	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
700598018068	DNA binding site [nucleotide binding]
700598018069	active site
700598018070	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
700598018071	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
700598018072	active site
700598018073	catalytic triad [active]
700598018074	oxyanion hole [active]
700598018075	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700598018076	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
700598018077	active site
700598018078	catalytic triad [active]
700598018079	oxyanion hole [active]
700598018080	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
700598018081	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
700598018082	conserved cys residue [active]
700598018083	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598018084	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598018085	RibD C-terminal domain; Region: RibD_C; cl17279
700598018086	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
700598018087	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700598018088	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700598018089	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
700598018090	NADH dehydrogenase subunit B; Validated; Region: PRK06411
700598018091	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
700598018092	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
700598018093	NADH dehydrogenase subunit D; Validated; Region: PRK06075
700598018094	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
700598018095	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
700598018096	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
700598018097	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
700598018098	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
700598018099	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
700598018100	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
700598018101	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
700598018102	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
700598018103	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700598018104	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
700598018105	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700598018106	NADH dehydrogenase subunit 2; Validated; Region: ND2; MTH00011
700598018107	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700598018108	Peptidase family M48; Region: Peptidase_M48; cl12018
700598018109	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
700598018110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700598018111	DNA-binding site [nucleotide binding]; DNA binding site
700598018112	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700598018113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700598018114	homodimer interface [polypeptide binding]; other site
700598018115	catalytic residue [active]
700598018116	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700598018117	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700598018118	Histidine kinase; Region: His_kinase; pfam06580
700598018119	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700598018120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598018121	active site
700598018122	phosphorylation site [posttranslational modification]
700598018123	intermolecular recognition site; other site
700598018124	dimerization interface [polypeptide binding]; other site
700598018125	LytTr DNA-binding domain; Region: LytTR; smart00850
700598018126	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598018127	Ligand Binding Site [chemical binding]; other site
700598018128	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700598018129	Ligand Binding Site [chemical binding]; other site
700598018130	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
700598018131	HAMP domain; Region: HAMP; pfam00672
700598018132	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598018133	dimer interface [polypeptide binding]; other site
700598018134	phosphorylation site [posttranslational modification]
700598018135	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598018136	ATP binding site [chemical binding]; other site
700598018137	Mg2+ binding site [ion binding]; other site
700598018138	G-X-G motif; other site
700598018139	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700598018140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700598018141	active site
700598018142	phosphorylation site [posttranslational modification]
700598018143	intermolecular recognition site; other site
700598018144	dimerization interface [polypeptide binding]; other site
700598018145	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700598018146	DNA binding site [nucleotide binding]
700598018147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700598018148	TPR motif; other site
700598018149	binding surface
700598018150	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
700598018151	homotrimer interaction site [polypeptide binding]; other site
700598018152	putative active site [active]
700598018153	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700598018154	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700598018155	catalytic residue [active]
700598018156	dihydroorotase; Provisional; Region: PRK09237
700598018157	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598018158	active site
700598018159	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
700598018160	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
700598018161	Sodium Bile acid symporter family; Region: SBF; pfam01758
700598018162	Predicted transcriptional regulators [Transcription]; Region: COG1733
700598018163	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700598018164	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
700598018165	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
700598018166	catalytic residues [active]
700598018167	Uncharacterized conserved protein [Function unknown]; Region: COG2353
700598018168	YceI-like domain; Region: YceI; pfam04264
700598018169	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700598018170	Zn2+ binding site [ion binding]; other site
700598018171	Mg2+ binding site [ion binding]; other site
700598018172	polyphosphate kinase; Provisional; Region: PRK05443
700598018173	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
700598018174	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
700598018175	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
700598018176	domain interface [polypeptide binding]; other site
700598018177	active site
700598018178	catalytic site [active]
700598018179	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
700598018180	domain interface [polypeptide binding]; other site
700598018181	active site
700598018182	catalytic site [active]
700598018183	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
700598018184	Surface antigen; Region: Bac_surface_Ag; pfam01103
700598018185	GAF domain; Region: GAF_3; pfam13492
700598018186	GAF domain; Region: GAF_2; pfam13185
700598018187	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409
700598018188	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700598018189	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700598018190	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598018191	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598018192	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598018193	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598018194	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598018195	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598018196	RmuC family; Region: RmuC; pfam02646
700598018197	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700598018198	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700598018199	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700598018200	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598018201	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598018202	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598018203	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598018204	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598018205	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598018206	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
700598018207	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598018208	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
700598018209	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
700598018210	active site
700598018211	Fn3 associated; Region: Fn3_assoc; pfam13287
700598018212	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
700598018213	fructuronate transporter; Provisional; Region: PRK10034; cl15264
700598018214	GntP family permease; Region: GntP_permease; pfam02447
700598018215	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
700598018216	homotrimer interaction site [polypeptide binding]; other site
700598018217	putative active site [active]
700598018218	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700598018219	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
700598018220	substrate binding site [chemical binding]; other site
700598018221	ATP binding site [chemical binding]; other site
700598018222	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700598018223	active site
700598018224	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
700598018225	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700598018226	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700598018227	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
700598018228	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700598018229	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598018230	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598018231	DNA binding residues [nucleotide binding]
700598018232	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
700598018233	FecR protein; Region: FecR; pfam04773
700598018234	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598018235	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598018236	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598018237	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598018238	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
700598018239	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598018240	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
700598018241	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598018242	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700598018243	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
700598018244	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700598018245	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
700598018246	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
700598018247	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
700598018248	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700598018249	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700598018250	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700598018251	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598018252	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598018253	Uncharacterized conserved protein [Function unknown]; Region: COG1262
700598018254	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
700598018255	BNR repeat-like domain; Region: BNR_2; pfam13088
700598018256	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
700598018257	Asp-box motif; other site
700598018258	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598018259	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598018260	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598018261	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598018262	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
700598018263	starch binding outer membrane protein SusD; Region: SusD; cl17845
700598018264	Family description; Region: VCBS; pfam13517
700598018265	Family description; Region: VCBS; pfam13517
700598018266	Family description; Region: VCBS; pfam13517
700598018267	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
700598018268	Family description; Region: VCBS; pfam13517
700598018269	Family description; Region: VCBS; pfam13517
700598018270	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
700598018271	active site
700598018272	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598018273	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700598018274	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700598018275	DinB family; Region: DinB; cl17821
700598018276	DinB superfamily; Region: DinB_2; pfam12867
700598018277	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
700598018278	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
700598018279	Na binding site [ion binding]; other site
700598018280	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700598018281	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700598018282	DNA binding site [nucleotide binding]
700598018283	domain linker motif; other site
700598018284	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700598018285	dimerization interface [polypeptide binding]; other site
700598018286	ligand binding site [chemical binding]; other site
700598018287	Family of unknown function (DUF706); Region: DUF706; pfam05153
700598018288	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
700598018289	Cna protein B-type domain; Region: Cna_B_2; pfam13715
700598018290	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
700598018291	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
700598018292	starch binding outer membrane protein SusD; Region: SusD; cd08977
700598018293	SusD family; Region: SusD; pfam07980
700598018294	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
700598018295	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
700598018296	Colicin V production protein; Region: Colicin_V; pfam02674
700598018297	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
700598018298	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
700598018299	gamma-glutamyl kinase; Provisional; Region: PRK05429
700598018300	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
700598018301	nucleotide binding site [chemical binding]; other site
700598018302	homotetrameric interface [polypeptide binding]; other site
700598018303	putative phosphate binding site [ion binding]; other site
700598018304	putative allosteric binding site; other site
700598018305	PUA domain; Region: PUA; pfam01472
700598018306	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
700598018307	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
700598018308	putative catalytic cysteine [active]
700598018309	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598018310	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598018311	active site
700598018312	catalytic tetrad [active]
700598018313	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
700598018314	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700598018315	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700598018316	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
700598018317	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700598018318	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700598018319	active site
700598018320	catalytic tetrad [active]
700598018321	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598018322	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598018323	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598018324	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598018325	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
700598018326	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
700598018327	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598018328	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598018329	PKD domain; Region: PKD; pfam00801
700598018330	FOG: PKD repeat [General function prediction only]; Region: COG3291
700598018331	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
700598018332	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
700598018333	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
700598018334	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
700598018335	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
700598018336	generic binding surface II; other site
700598018337	ssDNA binding site; other site
700598018338	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700598018339	ATP binding site [chemical binding]; other site
700598018340	putative Mg++ binding site [ion binding]; other site
700598018341	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700598018342	nucleotide binding region [chemical binding]; other site
700598018343	ATP-binding site [chemical binding]; other site
700598018344	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
700598018345	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
700598018346	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
700598018347	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700598018348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700598018349	dimer interface [polypeptide binding]; other site
700598018350	phosphorylation site [posttranslational modification]
700598018351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700598018352	ATP binding site [chemical binding]; other site
700598018353	Mg2+ binding site [ion binding]; other site
700598018354	G-X-G motif; other site
700598018355	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
700598018356	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
700598018357	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
700598018358	active site
700598018359	catalytic site [active]
700598018360	cell division protein MraZ; Reviewed; Region: PRK00326
700598018361	MraZ protein; Region: MraZ; pfam02381
700598018362	MraZ protein; Region: MraZ; pfam02381
700598018363	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
700598018364	MraW methylase family; Region: Methyltransf_5; cl17771
700598018365	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
700598018366	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
700598018367	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700598018368	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
700598018369	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
700598018370	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
700598018371	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700598018372	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700598018373	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
700598018374	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
700598018375	Mg++ binding site [ion binding]; other site
700598018376	putative catalytic motif [active]
700598018377	putative substrate binding site [chemical binding]; other site
700598018378	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
700598018379	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700598018380	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700598018381	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
700598018382	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
700598018383	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
700598018384	homodimer interface [polypeptide binding]; other site
700598018385	active site
700598018386	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
700598018387	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
700598018388	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700598018389	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700598018390	cell division protein FtsA; Region: ftsA; TIGR01174
700598018391	Cell division protein FtsA; Region: FtsA; smart00842
700598018392	Cell division protein FtsA; Region: FtsA; pfam14450
700598018393	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
700598018394	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
700598018395	nucleotide binding site [chemical binding]; other site
700598018396	SulA interaction site; other site
700598018397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700598018398	TIGR01777 family protein; Region: yfcH
700598018399	NAD(P) binding site [chemical binding]; other site
700598018400	active site
700598018401	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700598018402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700598018403	Walker A/P-loop; other site
700598018404	ATP binding site [chemical binding]; other site
700598018405	Q-loop/lid; other site
700598018406	ABC transporter signature motif; other site
700598018407	Walker B; other site
700598018408	D-loop; other site
700598018409	H-loop/switch region; other site
700598018410	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
700598018411	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
700598018412	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
700598018413	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
700598018414	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
700598018415	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700598018416	substrate binding site [chemical binding]; other site
700598018417	oxyanion hole (OAH) forming residues; other site
700598018418	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
700598018419	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
700598018420	MOFRL family; Region: MOFRL; pfam05161
700598018421	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
700598018422	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700598018423	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
700598018424	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
700598018425	active site
700598018426	HIGH motif; other site
700598018427	KMSKS motif; other site
700598018428	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
700598018429	anticodon binding site; other site
700598018430	tRNA binding surface [nucleotide binding]; other site
700598018431	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
700598018432	dimer interface [polypeptide binding]; other site
700598018433	putative tRNA-binding site [nucleotide binding]; other site
700598018434	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
700598018435	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598018436	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700598018437	DNA binding residues [nucleotide binding]
700598018438	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
700598018439	dimer interface [polypeptide binding]; other site
700598018440	catalytic triad [active]
700598018441	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
700598018442	dimer interface [polypeptide binding]; other site
700598018443	catalytic triad [active]
700598018444	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700598018445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700598018446	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
700598018447	dimerization interface [polypeptide binding]; other site
700598018448	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700598018449	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700598018450	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700598018451	K+ potassium transporter; Region: K_trans; pfam02705
700598018452	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
700598018453	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
700598018454	putative active site [active]
700598018455	catalytic triad [active]
700598018456	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
700598018457	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
700598018458	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
700598018459	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
700598018460	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
700598018461	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700598018462	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700598018463	DNA binding residues [nucleotide binding]
700598018464	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
700598018465	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
700598018466	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
700598018467	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
700598018468	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
700598018469	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
700598018470	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
700598018471	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
700598018472	dimer interface [polypeptide binding]; other site
700598018473	active site
700598018474	glycine-pyridoxal phosphate binding site [chemical binding]; other site
700598018475	folate binding site [chemical binding]; other site
700598018476	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700598018477	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
700598018478	active site
700598018479	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
700598018480	putative trimer interface [polypeptide binding]; other site
700598018481	putative CoA binding site [chemical binding]; other site
700598018482	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
700598018483	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
700598018484	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
700598018485	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
700598018486	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
700598018487	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
700598018488	ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269
700598018489	Walker A/P-loop; other site
700598018490	ATP binding site [chemical binding]; other site
700598018491	Q-loop/lid; other site
700598018492	ABC transporter signature motif; other site
700598018493	Walker B; other site
700598018494	D-loop; other site
700598018495	H-loop/switch region; other site
700598018496	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
700598018497	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981
700598018498	Zn binding site [ion binding]; other site
700598018499	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
700598018500	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700598018501	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500