-- dump date   	20140619_164025
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
749222000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
749222000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
749222000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222000004	Walker A motif; other site
749222000005	ATP binding site [chemical binding]; other site
749222000006	Walker B motif; other site
749222000007	arginine finger; other site
749222000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
749222000009	DnaA box-binding interface [nucleotide binding]; other site
749222000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
749222000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
749222000012	putative DNA binding surface [nucleotide binding]; other site
749222000013	dimer interface [polypeptide binding]; other site
749222000014	beta-clamp/clamp loader binding surface; other site
749222000015	beta-clamp/translesion DNA polymerase binding surface; other site
749222000016	CTP synthetase; Validated; Region: pyrG; PRK05380
749222000017	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
749222000018	Catalytic site [active]
749222000019	active site
749222000020	UTP binding site [chemical binding]; other site
749222000021	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
749222000022	active site
749222000023	putative oxyanion hole; other site
749222000024	catalytic triad [active]
749222000025	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
749222000026	DHH family; Region: DHH; pfam01368
749222000027	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
749222000028	active site residue [active]
749222000029	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
749222000030	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
749222000031	active site
749222000032	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
749222000033	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
749222000034	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
749222000035	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
749222000036	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
749222000037	catalytic residue [active]
749222000038	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
749222000039	homodecamer interface [polypeptide binding]; other site
749222000040	GTP cyclohydrolase I; Provisional; Region: PLN03044
749222000041	active site
749222000042	putative catalytic site residues [active]
749222000043	zinc binding site [ion binding]; other site
749222000044	GTP-CH-I/GFRP interaction surface; other site
749222000045	trigger factor; Provisional; Region: tig; PRK01490
749222000046	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
749222000047	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
749222000048	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
749222000049	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
749222000050	oligomer interface [polypeptide binding]; other site
749222000051	active site residues [active]
749222000052	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
749222000053	active site
749222000054	catalytic residues [active]
749222000055	metal binding site [ion binding]; metal-binding site
749222000056	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
749222000057	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
749222000058	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
749222000059	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
749222000060	Predicted membrane protein [Function unknown]; Region: COG2855
749222000061	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
749222000062	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
749222000063	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
749222000064	putative dimerization interface [polypeptide binding]; other site
749222000065	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
749222000066	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
749222000067	GTP binding site; other site
749222000068	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
749222000069	RDD family; Region: RDD; pfam06271
749222000070	Predicted amidohydrolase [General function prediction only]; Region: COG0388
749222000071	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
749222000072	active site
749222000073	catalytic triad [active]
749222000074	dimer interface [polypeptide binding]; other site
749222000075	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
749222000076	Methyltransferase domain; Region: Methyltransf_18; pfam12847
749222000077	Protein of unknown function (DUF3972); Region: DUF3972; pfam13118
749222000078	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
749222000079	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
749222000080	G1 box; other site
749222000081	GTP/Mg2+ binding site [chemical binding]; other site
749222000082	Switch I region; other site
749222000083	G2 box; other site
749222000084	G3 box; other site
749222000085	Switch II region; other site
749222000086	G4 box; other site
749222000087	G5 box; other site
749222000088	Nucleoside recognition; Region: Gate; pfam07670
749222000089	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
749222000090	Nucleoside recognition; Region: Gate; pfam07670
749222000091	FeoA domain; Region: FeoA; pfam04023
749222000092	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
749222000093	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
749222000094	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222000095	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222000096	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
749222000097	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
749222000098	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
749222000099	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
749222000100	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
749222000101	Cysteine-rich domain; Region: CCG; pfam02754
749222000102	Cysteine-rich domain; Region: CCG; pfam02754
749222000103	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
749222000104	FMN binding site [chemical binding]; other site
749222000105	dimer interface [polypeptide binding]; other site
749222000106	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
749222000107	dephospho-CoA kinase; Region: TIGR00152
749222000108	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
749222000109	CoA-binding site [chemical binding]; other site
749222000110	ATP-binding [chemical binding]; other site
749222000111	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
749222000112	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
749222000113	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
749222000114	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
749222000115	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
749222000116	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
749222000117	TrkA-N domain; Region: TrkA_N; pfam02254
749222000118	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
749222000119	Cna protein B-type domain; Region: Cna_B; pfam05738
749222000120	Cna protein B-type domain; Region: Cna_B; pfam05738
749222000121	Cna protein B-type domain; Region: Cna_B; pfam05738
749222000122	Cna protein B-type domain; Region: Cna_B; pfam05738
749222000123	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
749222000124	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
749222000125	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
749222000126	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
749222000127	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
749222000128	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
749222000129	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
749222000130	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
749222000131	NlpC/P60 family; Region: NLPC_P60; pfam00877
749222000132	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
749222000133	23S rRNA binding site [nucleotide binding]; other site
749222000134	L21 binding site [polypeptide binding]; other site
749222000135	L13 binding site [polypeptide binding]; other site
749222000136	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
749222000137	Domain of unknown function DUF87; Region: DUF87; pfam01935
749222000138	AAA-like domain; Region: AAA_10; pfam12846
749222000139	Type II/IV secretion system protein; Region: T2SE; pfam00437
749222000140	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
749222000141	Walker A motif; other site
749222000142	ATP binding site [chemical binding]; other site
749222000143	Walker B motif; other site
749222000144	type II secretion system protein D; Region: type_II_gspD; TIGR02517
749222000145	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
749222000146	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
749222000147	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
749222000148	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
749222000149	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
749222000150	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
749222000151	recombination factor protein RarA; Reviewed; Region: PRK13342
749222000152	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222000153	Walker A motif; other site
749222000154	ATP binding site [chemical binding]; other site
749222000155	Walker B motif; other site
749222000156	arginine finger; other site
749222000157	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
749222000158	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
749222000159	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
749222000160	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
749222000161	RNA binding surface [nucleotide binding]; other site
749222000162	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
749222000163	active site
749222000164	KpsF/GutQ family protein; Region: kpsF; TIGR00393
749222000165	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
749222000166	putative active site [active]
749222000167	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
749222000168	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
749222000169	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
749222000170	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
749222000171	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
749222000172	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
749222000173	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
749222000174	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
749222000175	substrate binding site [chemical binding]; other site
749222000176	glutamase interaction surface [polypeptide binding]; other site
749222000177	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
749222000178	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462
749222000179	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222000180	FeS/SAM binding site; other site
749222000181	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
749222000182	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
749222000183	active site
749222000184	adenylosuccinate lyase; Provisional; Region: PRK08470
749222000185	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
749222000186	tetramer interface [polypeptide binding]; other site
749222000187	active site
749222000188	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
749222000189	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447
749222000190	ATP cone domain; Region: ATP-cone; pfam03477
749222000191	Class I ribonucleotide reductase; Region: RNR_I; cd01679
749222000192	active site
749222000193	dimer interface [polypeptide binding]; other site
749222000194	catalytic residues [active]
749222000195	effector binding site; other site
749222000196	R2 peptide binding site; other site
749222000197	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
749222000198	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
749222000199	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
749222000200	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
749222000201	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
749222000202	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
749222000203	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
749222000204	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
749222000205	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
749222000206	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
749222000207	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
749222000208	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
749222000209	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
749222000210	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
749222000211	putative substrate-binding site; other site
749222000212	nickel binding site [ion binding]; other site
749222000213	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
749222000214	Acylphosphatase; Region: Acylphosphatase; pfam00708
749222000215	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
749222000216	HypF finger; Region: zf-HYPF; pfam07503
749222000217	HypF finger; Region: zf-HYPF; pfam07503
749222000218	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
749222000219	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
749222000220	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
749222000221	PDGLE domain; Region: PDGLE; pfam13190
749222000222	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
749222000223	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
749222000224	Walker A/P-loop; other site
749222000225	ATP binding site [chemical binding]; other site
749222000226	Q-loop/lid; other site
749222000227	ABC transporter signature motif; other site
749222000228	Walker B; other site
749222000229	D-loop; other site
749222000230	H-loop/switch region; other site
749222000231	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
749222000232	HupF/HypC family; Region: HupF_HypC; cl00394
749222000233	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
749222000234	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
749222000235	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
749222000236	dimerization interface [polypeptide binding]; other site
749222000237	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
749222000238	ATP binding site [chemical binding]; other site
749222000239	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
749222000240	putative active site [active]
749222000241	putative substrate binding site [chemical binding]; other site
749222000242	putative cosubstrate binding site; other site
749222000243	catalytic site [active]
749222000244	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
749222000245	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
749222000246	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
749222000247	substrate binding site [chemical binding]; other site
749222000248	oxyanion hole (OAH) forming residues; other site
749222000249	trimer interface [polypeptide binding]; other site
749222000250	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
749222000251	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
749222000252	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222000253	peroxiredoxin; Region: AhpC; TIGR03137
749222000254	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
749222000255	dimer interface [polypeptide binding]; other site
749222000256	decamer (pentamer of dimers) interface [polypeptide binding]; other site
749222000257	catalytic triad [active]
749222000258	peroxidatic and resolving cysteines [active]
749222000259	AAA domain; Region: AAA_14; pfam13173
749222000260	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
749222000261	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
749222000262	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
749222000263	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
749222000264	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
749222000265	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
749222000266	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
749222000267	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
749222000268	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
749222000269	putative translocon binding site; other site
749222000270	protein-rRNA interface [nucleotide binding]; other site
749222000271	Uncharacterized conserved protein [Function unknown]; Region: COG3743
749222000272	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
749222000273	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
749222000274	G-X-X-G motif; other site
749222000275	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
749222000276	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
749222000277	23S rRNA interface [nucleotide binding]; other site
749222000278	5S rRNA interface [nucleotide binding]; other site
749222000279	putative antibiotic binding site [chemical binding]; other site
749222000280	L25 interface [polypeptide binding]; other site
749222000281	L27 interface [polypeptide binding]; other site
749222000282	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
749222000283	putative translocon interaction site; other site
749222000284	23S rRNA interface [nucleotide binding]; other site
749222000285	signal recognition particle (SRP54) interaction site; other site
749222000286	L23 interface [polypeptide binding]; other site
749222000287	trigger factor interaction site; other site
749222000288	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
749222000289	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
749222000290	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
749222000291	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
749222000292	RNA binding site [nucleotide binding]; other site
749222000293	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
749222000294	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
749222000295	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
749222000296	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
749222000297	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
749222000298	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
749222000299	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
749222000300	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
749222000301	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
749222000302	5S rRNA interface [nucleotide binding]; other site
749222000303	L27 interface [polypeptide binding]; other site
749222000304	23S rRNA interface [nucleotide binding]; other site
749222000305	L5 interface [polypeptide binding]; other site
749222000306	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
749222000307	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
749222000308	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
749222000309	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
749222000310	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
749222000311	SecY translocase; Region: SecY; pfam00344
749222000312	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
749222000313	active site
749222000314	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
749222000315	rRNA binding site [nucleotide binding]; other site
749222000316	predicted 30S ribosome binding site; other site
749222000317	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
749222000318	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
749222000319	30S ribosomal protein S13; Region: bact_S13; TIGR03631
749222000320	30S ribosomal protein S11; Validated; Region: PRK05309
749222000321	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
749222000322	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
749222000323	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
749222000324	RNA binding surface [nucleotide binding]; other site
749222000325	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
749222000326	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
749222000327	alphaNTD homodimer interface [polypeptide binding]; other site
749222000328	alphaNTD - beta interaction site [polypeptide binding]; other site
749222000329	alphaNTD - beta' interaction site [polypeptide binding]; other site
749222000330	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
749222000331	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
749222000332	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
749222000333	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
749222000334	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
749222000335	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
749222000336	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
749222000337	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
749222000338	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
749222000339	Divergent AAA domain; Region: AAA_4; pfam04326
749222000340	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
749222000341	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
749222000342	nudix motif; other site
749222000343	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
749222000344	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
749222000345	Fe binding site [ion binding]; other site
749222000346	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
749222000347	dimer interface [polypeptide binding]; other site
749222000348	[2Fe-2S] cluster binding site [ion binding]; other site
749222000349	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
749222000350	tetramerization interface [polypeptide binding]; other site
749222000351	active site
749222000352	hypothetical protein; Provisional; Region: PRK03762
749222000353	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
749222000354	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
749222000355	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
749222000356	RNA/DNA hybrid binding site [nucleotide binding]; other site
749222000357	active site
749222000358	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
749222000359	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222000360	Walker A/P-loop; other site
749222000361	ATP binding site [chemical binding]; other site
749222000362	Q-loop/lid; other site
749222000363	ABC transporter signature motif; other site
749222000364	Walker B; other site
749222000365	D-loop; other site
749222000366	H-loop/switch region; other site
749222000367	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
749222000368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
749222000369	dimer interface [polypeptide binding]; other site
749222000370	conserved gate region; other site
749222000371	putative PBP binding loops; other site
749222000372	ABC-ATPase subunit interface; other site
749222000373	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
749222000374	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
749222000375	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
749222000376	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
749222000377	four helix bundle protein; Region: TIGR02436
749222000378	DNA topoisomerase I; Validated; Region: PRK05582
749222000379	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
749222000380	active site
749222000381	interdomain interaction site; other site
749222000382	putative metal-binding site [ion binding]; other site
749222000383	nucleotide binding site [chemical binding]; other site
749222000384	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
749222000385	domain I; other site
749222000386	DNA binding groove [nucleotide binding]
749222000387	phosphate binding site [ion binding]; other site
749222000388	domain II; other site
749222000389	domain III; other site
749222000390	nucleotide binding site [chemical binding]; other site
749222000391	catalytic site [active]
749222000392	domain IV; other site
749222000393	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
749222000394	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
749222000395	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
749222000396	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
749222000397	heterotetramer interface [polypeptide binding]; other site
749222000398	active site pocket [active]
749222000399	cleavage site
749222000400	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
749222000401	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
749222000402	putative ligand binding pocket/active site [active]
749222000403	putative metal binding site [ion binding]; other site
749222000404	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
749222000405	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222000406	FeS/SAM binding site; other site
749222000407	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
749222000408	AMMECR1; Region: AMMECR1; pfam01871
749222000409	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
749222000410	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
749222000411	substrate binding site [chemical binding]; other site
749222000412	hexamer interface [polypeptide binding]; other site
749222000413	metal binding site [ion binding]; metal-binding site
749222000414	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
749222000415	active site
749222000416	DNA polymerase III subunit epsilon; Provisional; Region: PRK08517
749222000417	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
749222000418	active site
749222000419	catalytic site [active]
749222000420	substrate binding site [chemical binding]; other site
749222000421	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
749222000422	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
749222000423	dimer interface [polypeptide binding]; other site
749222000424	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222000425	catalytic residue [active]
749222000426	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
749222000427	active site clefts [active]
749222000428	zinc binding site [ion binding]; other site
749222000429	dimer interface [polypeptide binding]; other site
749222000430	dihydroorotase; Provisional; Region: PRK05451
749222000431	active site
749222000432	Haemolytic domain; Region: Haemolytic; pfam01809
749222000433	NADH dehydrogenase subunit A; Validated; Region: PRK08489
749222000434	NADH dehydrogenase subunit B; Validated; Region: PRK06411
749222000435	NADH dehydrogenase subunit C; Provisional; Region: PRK08491
749222000436	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
749222000437	NADH dehydrogenase subunit D; Validated; Region: PRK06075
749222000438	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
749222000439	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
749222000440	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
749222000441	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
749222000442	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
749222000443	NADH dehydrogenase subunit G; Validated; Region: PRK08493
749222000444	catalytic loop [active]
749222000445	iron binding site [ion binding]; other site
749222000446	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
749222000447	4Fe-4S binding domain; Region: Fer4_6; pfam12837
749222000448	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
749222000449	molybdopterin cofactor binding site; other site
749222000450	NADH dehydrogenase subunit G; Validated; Region: PRK08493
749222000451	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
749222000452	catalytic loop [active]
749222000453	iron binding site [ion binding]; other site
749222000454	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
749222000455	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
749222000456	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
749222000457	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
749222000458	4Fe-4S binding domain; Region: Fer4; pfam00037
749222000459	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
749222000460	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
749222000461	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
749222000462	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
749222000463	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
749222000464	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
749222000465	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
749222000466	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
749222000467	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
749222000468	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
749222000469	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
749222000470	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
749222000471	prenyltransferase; Reviewed; Region: ubiA; PRK12874
749222000472	UbiA prenyltransferase family; Region: UbiA; pfam01040
749222000473	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
749222000474	ligand binding site [chemical binding]; other site
749222000475	active site
749222000476	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
749222000477	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
749222000478	catalytic site [active]
749222000479	G-X2-G-X-G-K; other site
749222000480	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
749222000481	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
749222000482	arginine-tRNA ligase; Region: PLN02286
749222000483	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
749222000484	active site
749222000485	HIGH motif; other site
749222000486	KMSK motif region; other site
749222000487	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
749222000488	tRNA binding surface [nucleotide binding]; other site
749222000489	anticodon binding site; other site
749222000490	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
749222000491	Ferritin-like domain; Region: Ferritin; pfam00210
749222000492	diiron binding motif [ion binding]; other site
749222000493	Rubrerythrin [Energy production and conversion]; Region: COG1592
749222000494	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
749222000495	binuclear metal center [ion binding]; other site
749222000496	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
749222000497	iron binding site [ion binding]; other site
749222000498	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
749222000499	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
749222000500	dimer interface [polypeptide binding]; other site
749222000501	active site
749222000502	heme binding site [chemical binding]; other site
749222000503	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
749222000504	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
749222000505	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
749222000506	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
749222000507	active site
749222000508	(T/H)XGH motif; other site
749222000509	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
749222000510	Phosphoglycerate kinase; Region: PGK; pfam00162
749222000511	substrate binding site [chemical binding]; other site
749222000512	hinge regions; other site
749222000513	ADP binding site [chemical binding]; other site
749222000514	catalytic site [active]
749222000515	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
749222000516	triosephosphate isomerase; Provisional; Region: PRK14565
749222000517	substrate binding site [chemical binding]; other site
749222000518	dimer interface [polypeptide binding]; other site
749222000519	catalytic triad [active]
749222000520	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
749222000521	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
749222000522	putative PBP binding loops; other site
749222000523	dimer interface [polypeptide binding]; other site
749222000524	ABC-ATPase subunit interface; other site
749222000525	transcription elongation factor NusA; Provisional; Region: nusA; PRK12328
749222000526	NusA N-terminal domain; Region: NusA_N; pfam08529
749222000527	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
749222000528	RNA binding site [nucleotide binding]; other site
749222000529	homodimer interface [polypeptide binding]; other site
749222000530	NusA-like KH domain; Region: KH_5; pfam13184
749222000531	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
749222000532	G-X-X-G motif; other site
749222000533	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
749222000534	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339
749222000535	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222000536	FeS/SAM binding site; other site
749222000537	TRAM domain; Region: TRAM; cl01282
749222000538	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
749222000539	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
749222000540	active site
749222000541	DNA binding site [nucleotide binding]
749222000542	Int/Topo IB signature motif; other site
749222000543	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904
749222000544	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
749222000545	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
749222000546	recombinase A; Provisional; Region: recA; PRK09354
749222000547	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
749222000548	hexamer interface [polypeptide binding]; other site
749222000549	Walker A motif; other site
749222000550	ATP binding site [chemical binding]; other site
749222000551	Walker B motif; other site
749222000552	enolase; Provisional; Region: eno; PRK00077
749222000553	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
749222000554	dimer interface [polypeptide binding]; other site
749222000555	metal binding site [ion binding]; metal-binding site
749222000556	substrate binding pocket [chemical binding]; other site
749222000557	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
749222000558	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
749222000559	biotin synthase; Provisional; Region: PRK08508
749222000560	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222000561	FeS/SAM binding site; other site
749222000562	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
749222000563	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
749222000564	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
749222000565	active site
749222000566	metal binding site [ion binding]; metal-binding site
749222000567	homotetramer interface [polypeptide binding]; other site
749222000568	FAD binding domain; Region: FAD_binding_4; pfam01565
749222000569	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
749222000570	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
749222000571	Peptidase family M23; Region: Peptidase_M23; pfam01551
749222000572	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
749222000573	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
749222000574	dimer interface [polypeptide binding]; other site
749222000575	ADP-ribose binding site [chemical binding]; other site
749222000576	active site
749222000577	nudix motif; other site
749222000578	metal binding site [ion binding]; metal-binding site
749222000579	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
749222000580	heme-binding site [chemical binding]; other site
749222000581	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
749222000582	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
749222000583	putative active site; other site
749222000584	catalytic triad [active]
749222000585	putative dimer interface [polypeptide binding]; other site
749222000586	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
749222000587	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
749222000588	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
749222000589	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
749222000590	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
749222000591	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
749222000592	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
749222000593	alanine racemase; Reviewed; Region: alr; PRK00053
749222000594	active site
749222000595	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
749222000596	dimer interface [polypeptide binding]; other site
749222000597	substrate binding site [chemical binding]; other site
749222000598	catalytic residues [active]
749222000599	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
749222000600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222000601	active site
749222000602	phosphorylation site [posttranslational modification]
749222000603	intermolecular recognition site; other site
749222000604	dimerization interface [polypeptide binding]; other site
749222000605	Helix-turn-helix domain; Region: HTH_17; cl17695
749222000606	L-asparaginase II; Region: Asparaginase_II; cl01842
749222000607	RecT family; Region: RecT; cl04285
749222000608	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
749222000609	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
749222000610	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
749222000611	Helix-turn-helix domain; Region: HTH_17; pfam12728
749222000612	integrase; Provisional; Region: PRK09692
749222000613	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
749222000614	active site
749222000615	Int/Topo IB signature motif; other site
749222000616	LysE type translocator; Region: LysE; cl00565
749222000617	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
749222000618	UGMP family protein; Validated; Region: PRK09604
749222000619	Serine hydrolase; Region: Ser_hydrolase; cl17834
749222000620	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
749222000621	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
749222000622	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
749222000623	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
749222000624	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
749222000625	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
749222000626	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
749222000627	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
749222000628	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
749222000629	Domain of unknown function (DUF814); Region: DUF814; pfam05670
749222000630	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
749222000631	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
749222000632	substrate binding site [chemical binding]; other site
749222000633	ligand binding site [chemical binding]; other site
749222000634	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
749222000635	NADPH bind site [chemical binding]; other site
749222000636	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
749222000637	putative FMN binding site [chemical binding]; other site
749222000638	NADPH bind site [chemical binding]; other site
749222000639	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
749222000640	putative active site [active]
749222000641	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
749222000642	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
749222000643	catalytic loop [active]
749222000644	iron binding site [ion binding]; other site
749222000645	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
749222000646	L-aspartate oxidase; Provisional; Region: PRK06175
749222000647	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
749222000648	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
749222000649	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
749222000650	putative ligand binding site [chemical binding]; other site
749222000651	putative NAD binding site [chemical binding]; other site
749222000652	catalytic site [active]
749222000653	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
749222000654	Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729
749222000655	putative active site [active]
749222000656	redox center [active]
749222000657	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
749222000658	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
749222000659	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
749222000660	ATP-grasp domain; Region: ATP-grasp; pfam02222
749222000661	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
749222000662	Uncharacterized conserved protein [Function unknown]; Region: COG0062
749222000663	putative carbohydrate kinase; Provisional; Region: PRK10565
749222000664	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
749222000665	putative substrate binding site [chemical binding]; other site
749222000666	putative ATP binding site [chemical binding]; other site
749222000667	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
749222000668	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
749222000669	active site
749222000670	substrate binding site [chemical binding]; other site
749222000671	cosubstrate binding site; other site
749222000672	catalytic site [active]
749222000673	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
749222000674	ThiS interaction site; other site
749222000675	putative active site [active]
749222000676	tetramer interface [polypeptide binding]; other site
749222000677	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
749222000678	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
749222000679	substrate binding site [chemical binding]; other site
749222000680	active site
749222000681	catalytic residues [active]
749222000682	heterodimer interface [polypeptide binding]; other site
749222000683	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
749222000684	oligomerization interface [polypeptide binding]; other site
749222000685	active site
749222000686	metal binding site [ion binding]; metal-binding site
749222000687	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
749222000688	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222000689	Walker A motif; other site
749222000690	ATP binding site [chemical binding]; other site
749222000691	Walker B motif; other site
749222000692	arginine finger; other site
749222000693	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
749222000694	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
749222000695	Domain of unknown function DUF20; Region: UPF0118; pfam01594
749222000696	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222000697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222000698	active site
749222000699	phosphorylation site [posttranslational modification]
749222000700	intermolecular recognition site; other site
749222000701	dimerization interface [polypeptide binding]; other site
749222000702	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222000703	DNA binding site [nucleotide binding]
749222000704	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222000705	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
749222000706	dimerization interface [polypeptide binding]; other site
749222000707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222000708	dimer interface [polypeptide binding]; other site
749222000709	phosphorylation site [posttranslational modification]
749222000710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222000711	ATP binding site [chemical binding]; other site
749222000712	Mg2+ binding site [ion binding]; other site
749222000713	G-X-G motif; other site
749222000714	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
749222000715	catalytic triad [active]
749222000716	putative active site [active]
749222000717	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
749222000718	Cysteine-rich domain; Region: CCG; pfam02754
749222000719	Cysteine-rich domain; Region: CCG; pfam02754
749222000720	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
749222000721	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222000722	FeS/SAM binding site; other site
749222000723	HemN C-terminal domain; Region: HemN_C; pfam06969
749222000724	ornithine carbamoyltransferase; Provisional; Region: PRK00779
749222000725	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
749222000726	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
749222000727	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222000728	Walker A motif; other site
749222000729	ATP binding site [chemical binding]; other site
749222000730	Walker B motif; other site
749222000731	arginine finger; other site
749222000732	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
749222000733	VWA-like domain (DUF2201); Region: DUF2201; pfam09967
749222000734	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
749222000735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222000736	Walker A motif; other site
749222000737	ATP binding site [chemical binding]; other site
749222000738	Walker B motif; other site
749222000739	arginine finger; other site
749222000740	Predicted metalloprotease [General function prediction only]; Region: COG2321
749222000741	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
749222000742	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
749222000743	PAS fold; Region: PAS_3; pfam08447
749222000744	putative active site [active]
749222000745	heme pocket [chemical binding]; other site
749222000746	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
749222000747	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
749222000748	metal binding site [ion binding]; metal-binding site
749222000749	active site
749222000750	I-site; other site
749222000751	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
749222000752	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
749222000753	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
749222000754	HIGH motif; other site
749222000755	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
749222000756	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
749222000757	active site
749222000758	KMSKS motif; other site
749222000759	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
749222000760	tRNA binding surface [nucleotide binding]; other site
749222000761	Lipopolysaccharide-assembly; Region: LptE; pfam04390
749222000762	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
749222000763	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
749222000764	DEAD-like helicases superfamily; Region: DEXDc; smart00487
749222000765	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
749222000766	ATP binding site [chemical binding]; other site
749222000767	putative Mg++ binding site [ion binding]; other site
749222000768	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
749222000769	nucleotide binding region [chemical binding]; other site
749222000770	ATP-binding site [chemical binding]; other site
749222000771	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
749222000772	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
749222000773	MoxR-like ATPases [General function prediction only]; Region: COG0714
749222000774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222000775	Walker A motif; other site
749222000776	ATP binding site [chemical binding]; other site
749222000777	Walker B motif; other site
749222000778	arginine finger; other site
749222000779	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
749222000780	Protein of unknown function DUF58; Region: DUF58; pfam01882
749222000781	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
749222000782	metal ion-dependent adhesion site (MIDAS); other site
749222000783	potential frameshift: common BLAST hit: gi|152990153|ref|YP_001355875.1| von Willebrand factor type A domain-containing protein
749222000784	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
749222000785	von Willebrand factor type A domain; Region: VWA_2; pfam13519
749222000786	metal ion-dependent adhesion site (MIDAS); other site
749222000787	TPR repeat; Region: TPR_11; pfam13414
749222000788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
749222000789	binding surface
749222000790	TPR motif; other site
749222000791	Oxygen tolerance; Region: BatD; pfam13584
749222000792	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
749222000793	prephenate dehydrogenase; Validated; Region: PRK08507
749222000794	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
749222000795	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
749222000796	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
749222000797	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
749222000798	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
749222000799	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
749222000800	Surface antigen; Region: Bac_surface_Ag; pfam01103
749222000801	para-aminobenzoate synthase component I; Validated; Region: PRK07093
749222000802	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
749222000803	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
749222000804	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
749222000805	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
749222000806	AAA domain; Region: AAA_26; pfam13500
749222000807	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
749222000808	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
749222000809	Clp amino terminal domain; Region: Clp_N; pfam02861
749222000810	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222000811	Walker A motif; other site
749222000812	ATP binding site [chemical binding]; other site
749222000813	Walker B motif; other site
749222000814	arginine finger; other site
749222000815	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222000816	Walker A motif; other site
749222000817	ATP binding site [chemical binding]; other site
749222000818	Walker B motif; other site
749222000819	arginine finger; other site
749222000820	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
749222000821	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
749222000822	Class I aldolases; Region: Aldolase_Class_I; cl17187
749222000823	transaldolase; Provisional; Region: PRK03903
749222000824	catalytic residue [active]
749222000825	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
749222000826	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
749222000827	ATP binding site [chemical binding]; other site
749222000828	Walker B motif; other site
749222000829	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
749222000830	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
749222000831	5S rRNA interface [nucleotide binding]; other site
749222000832	CTC domain interface [polypeptide binding]; other site
749222000833	L16 interface [polypeptide binding]; other site
749222000834	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
749222000835	putative active site [active]
749222000836	catalytic residue [active]
749222000837	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
749222000838	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
749222000839	diaminopimelate decarboxylase; Region: lysA; TIGR01048
749222000840	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
749222000841	active site
749222000842	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
749222000843	substrate binding site [chemical binding]; other site
749222000844	catalytic residues [active]
749222000845	dimer interface [polypeptide binding]; other site
749222000846	Chorismate mutase type II; Region: CM_2; smart00830
749222000847	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
749222000848	Prephenate dehydratase; Region: PDT; pfam00800
749222000849	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
749222000850	putative L-Phe binding site [chemical binding]; other site
749222000851	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
749222000852	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
749222000853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222000854	homodimer interface [polypeptide binding]; other site
749222000855	catalytic residue [active]
749222000856	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
749222000857	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
749222000858	TPP-binding site; other site
749222000859	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
749222000860	PYR/PP interface [polypeptide binding]; other site
749222000861	dimer interface [polypeptide binding]; other site
749222000862	TPP binding site [chemical binding]; other site
749222000863	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
749222000864	S-adenosylmethionine synthetase; Validated; Region: PRK05250
749222000865	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
749222000866	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
749222000867	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
749222000868	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
749222000869	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
749222000870	active site
749222000871	multimer interface [polypeptide binding]; other site
749222000872	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
749222000873	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
749222000874	putative phosphate acyltransferase; Provisional; Region: PRK05331
749222000875	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
749222000876	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
749222000877	dimer interface [polypeptide binding]; other site
749222000878	active site
749222000879	CoA binding pocket [chemical binding]; other site
749222000880	3-methyladenine DNA glycosylase; Provisional; Region: PRK13913
749222000881	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
749222000882	minor groove reading motif; other site
749222000883	helix-hairpin-helix signature motif; other site
749222000884	active site
749222000885	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
749222000886	metal-binding site [ion binding]
749222000887	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
749222000888	CPxP  motif; other site
749222000889	MerT mercuric transport protein; Region: MerT; cl03578
749222000890	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
749222000891	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
749222000892	selenophosphate synthetase; Provisional; Region: PRK00943
749222000893	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
749222000894	dimerization interface [polypeptide binding]; other site
749222000895	putative ATP binding site [chemical binding]; other site
749222000896	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
749222000897	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
749222000898	active site residue [active]
749222000899	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
749222000900	active site
749222000901	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
749222000902	putative active site [active]
749222000903	dimerization interface [polypeptide binding]; other site
749222000904	putative tRNAtyr binding site [nucleotide binding]; other site
749222000905	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
749222000906	argininosuccinate lyase; Provisional; Region: PRK00855
749222000907	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
749222000908	active sites [active]
749222000909	tetramer interface [polypeptide binding]; other site
749222000910	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
749222000911	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
749222000912	Cna protein B-type domain; Region: Cna_B; pfam05738
749222000913	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
749222000914	Domain of unknown function DUF11; Region: DUF11; cl17728
749222000915	Cna protein B-type domain; Region: Cna_B; pfam05738
749222000916	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
749222000917	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
749222000918	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
749222000919	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
749222000920	Cna protein B-type domain; Region: Cna_B; pfam05738
749222000921	Domain of unknown function DUF11; Region: DUF11; pfam01345
749222000922	Cna protein B-type domain; Region: Cna_B; pfam05738
749222000923	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
749222000924	Cna protein B-type domain; Region: Cna_B; pfam05738
749222000925	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
749222000926	exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178
749222000927	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
749222000928	nucleotide binding site/active site [active]
749222000929	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
749222000930	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
749222000931	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
749222000932	dimer interface [polypeptide binding]; other site
749222000933	motif 1; other site
749222000934	active site
749222000935	motif 2; other site
749222000936	motif 3; other site
749222000937	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
749222000938	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
749222000939	putative tRNA-binding site [nucleotide binding]; other site
749222000940	B3/4 domain; Region: B3_4; pfam03483
749222000941	tRNA synthetase B5 domain; Region: B5; pfam03484
749222000942	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
749222000943	dimer interface [polypeptide binding]; other site
749222000944	motif 1; other site
749222000945	motif 3; other site
749222000946	motif 2; other site
749222000947	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
749222000948	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
749222000949	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
749222000950	hinge; other site
749222000951	active site
749222000952	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
749222000953	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
749222000954	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
749222000955	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
749222000956	RNA binding site [nucleotide binding]; other site
749222000957	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
749222000958	RNA binding site [nucleotide binding]; other site
749222000959	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
749222000960	RNA binding site [nucleotide binding]; other site
749222000961	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
749222000962	RNA binding site [nucleotide binding]; other site
749222000963	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
749222000964	RNA binding site [nucleotide binding]; other site
749222000965	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
749222000966	RNA binding site [nucleotide binding]; other site
749222000967	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
749222000968	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
749222000969	ligand binding site [chemical binding]; other site
749222000970	NAD binding site [chemical binding]; other site
749222000971	dimerization interface [polypeptide binding]; other site
749222000972	catalytic site [active]
749222000973	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
749222000974	putative L-serine binding site [chemical binding]; other site
749222000975	Outer membrane efflux protein; Region: OEP; pfam02321
749222000976	Outer membrane efflux protein; Region: OEP; pfam02321
749222000977	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
749222000978	HlyD family secretion protein; Region: HlyD_3; pfam13437
749222000979	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
749222000980	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
749222000981	elongation factor P; Validated; Region: PRK00529
749222000982	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
749222000983	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
749222000984	RNA binding site [nucleotide binding]; other site
749222000985	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
749222000986	RNA binding site [nucleotide binding]; other site
749222000987	DJ-1 family protein; Region: not_thiJ; TIGR01383
749222000988	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
749222000989	conserved cys residue [active]
749222000990	hypothetical protein; Provisional; Region: PRK08960
749222000991	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
749222000992	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222000993	homodimer interface [polypeptide binding]; other site
749222000994	catalytic residue [active]
749222000995	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
749222000996	RHS Repeat; Region: RHS_repeat; pfam05593
749222000997	RHS Repeat; Region: RHS_repeat; pfam05593
749222000998	RHS Repeat; Region: RHS_repeat; pfam05593
749222000999	RHS Repeat; Region: RHS_repeat; pfam05593
749222001000	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
749222001001	RHS protein; Region: RHS; pfam03527
749222001002	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
749222001003	RHS protein; Region: RHS; pfam03527
749222001004	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
749222001005	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
749222001006	RHS protein; Region: RHS; pfam03527
749222001007	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
749222001008	RHS protein; Region: RHS; pfam03527
749222001009	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
749222001010	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
749222001011	HEAT repeats; Region: HEAT_2; pfam13646
749222001012	RHS protein; Region: RHS; pfam03527
749222001013	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
749222001014	ArsC family; Region: ArsC; pfam03960
749222001015	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
749222001016	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
749222001017	active site
749222001018	PHP Thumb interface [polypeptide binding]; other site
749222001019	metal binding site [ion binding]; metal-binding site
749222001020	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
749222001021	generic binding surface I; other site
749222001022	generic binding surface II; other site
749222001023	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
749222001024	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
749222001025	malate dehydrogenase; Reviewed; Region: PRK06223
749222001026	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
749222001027	NAD(P) binding site [chemical binding]; other site
749222001028	dimer interface [polypeptide binding]; other site
749222001029	tetramer (dimer of dimers) interface [polypeptide binding]; other site
749222001030	substrate binding site [chemical binding]; other site
749222001031	fumarate hydratase; Provisional; Region: PRK06246
749222001032	Fumarase C-terminus; Region: Fumerase_C; cl00795
749222001033	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
749222001034	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
749222001035	CoA-ligase; Region: Ligase_CoA; pfam00549
749222001036	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
749222001037	CoA binding domain; Region: CoA_binding; smart00881
749222001038	CoA-ligase; Region: Ligase_CoA; pfam00549
749222001039	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
749222001040	Moco binding site; other site
749222001041	metal coordination site [ion binding]; other site
749222001042	Cytochrome c; Region: Cytochrom_C; pfam00034
749222001043	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
749222001044	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
749222001045	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
749222001046	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
749222001047	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
749222001048	Cytochrome c [Energy production and conversion]; Region: COG3258
749222001049	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
749222001050	active site
749222001051	metal binding site [ion binding]; metal-binding site
749222001052	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
749222001053	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
749222001054	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
749222001055	2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626
749222001056	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
749222001057	2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627
749222001058	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
749222001059	dimer interface [polypeptide binding]; other site
749222001060	PYR/PP interface [polypeptide binding]; other site
749222001061	TPP binding site [chemical binding]; other site
749222001062	substrate binding site [chemical binding]; other site
749222001063	2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628
749222001064	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
749222001065	TPP-binding site [chemical binding]; other site
749222001066	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
749222001067	2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441
749222001068	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
749222001069	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
749222001070	seryl-tRNA synthetase; Provisional; Region: PRK05431
749222001071	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
749222001072	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
749222001073	dimer interface [polypeptide binding]; other site
749222001074	active site
749222001075	motif 1; other site
749222001076	motif 2; other site
749222001077	motif 3; other site
749222001078	DNA polymerase III subunit delta; Validated; Region: PRK08487
749222001079	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
749222001080	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
749222001081	RNB domain; Region: RNB; pfam00773
749222001082	M48 family peptidase; Provisional; Region: PRK03001
749222001083	ketol-acid reductoisomerase; Provisional; Region: PRK05479
749222001084	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
749222001085	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
749222001086	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
749222001087	NodB motif; other site
749222001088	putative active site [active]
749222001089	putative catalytic site [active]
749222001090	Zn binding site [ion binding]; other site
749222001091	DNA protecting protein DprA; Region: dprA; TIGR00732
749222001092	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
749222001093	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
749222001094	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
749222001095	catalytic residues [active]
749222001096	DNA repair protein RadA; Provisional; Region: PRK11823
749222001097	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
749222001098	Walker A motif/ATP binding site; other site
749222001099	ATP binding site [chemical binding]; other site
749222001100	Walker B motif; other site
749222001101	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
749222001102	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
749222001103	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
749222001104	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
749222001105	P loop; other site
749222001106	GTP binding site [chemical binding]; other site
749222001107	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
749222001108	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
749222001109	phosphodiesterase; Provisional; Region: PRK12704
749222001110	KH domain; Region: KH_1; pfam00013
749222001111	nucleic acid binding region [nucleotide binding]; other site
749222001112	G-X-X-G motif; other site
749222001113	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
749222001114	Zn2+ binding site [ion binding]; other site
749222001115	Mg2+ binding site [ion binding]; other site
749222001116	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
749222001117	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
749222001118	active site
749222001119	Methyltransferase domain; Region: Methyltransf_31; pfam13847
749222001120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222001121	S-adenosylmethionine binding site [chemical binding]; other site
749222001122	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222001123	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222001124	DNA binding site [nucleotide binding]
749222001125	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
749222001126	active site 2 [active]
749222001127	active site 1 [active]
749222001128	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
749222001129	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
749222001130	dinuclear metal binding motif [ion binding]; other site
749222001131	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
749222001132	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
749222001133	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
749222001134	catalytic residue [active]
749222001135	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
749222001136	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
749222001137	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
749222001138	feedback inhibition sensing region; other site
749222001139	homohexameric interface [polypeptide binding]; other site
749222001140	nucleotide binding site [chemical binding]; other site
749222001141	N-acetyl-L-glutamate binding site [chemical binding]; other site
749222001142	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
749222001143	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
749222001144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222001145	catalytic residue [active]
749222001146	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
749222001147	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
749222001148	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
749222001149	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
749222001150	3D domain; Region: 3D; cl01439
749222001151	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
749222001152	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222001153	Walker A/P-loop; other site
749222001154	ATP binding site [chemical binding]; other site
749222001155	Q-loop/lid; other site
749222001156	ABC transporter signature motif; other site
749222001157	Walker B; other site
749222001158	D-loop; other site
749222001159	H-loop/switch region; other site
749222001160	ABC transporter; Region: ABC_tran_2; pfam12848
749222001161	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
749222001162	Peptidase family M48; Region: Peptidase_M48; pfam01435
749222001163	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
749222001164	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222001165	S-adenosylmethionine binding site [chemical binding]; other site
749222001166	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
749222001167	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
749222001168	putative active site [active]
749222001169	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
749222001170	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
749222001171	active site
749222001172	metal binding site [ion binding]; metal-binding site
749222001173	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
749222001174	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
749222001175	metal binding site [ion binding]; metal-binding site
749222001176	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222001177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222001178	active site
749222001179	phosphorylation site [posttranslational modification]
749222001180	intermolecular recognition site; other site
749222001181	dimerization interface [polypeptide binding]; other site
749222001182	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
749222001183	DNA binding site [nucleotide binding]
749222001184	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
749222001185	PAS domain; Region: PAS_9; pfam13426
749222001186	putative active site [active]
749222001187	heme pocket [chemical binding]; other site
749222001188	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
749222001189	dimer interface [polypeptide binding]; other site
749222001190	phosphorylation site [posttranslational modification]
749222001191	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222001192	ATP binding site [chemical binding]; other site
749222001193	Mg2+ binding site [ion binding]; other site
749222001194	G-X-G motif; other site
749222001195	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
749222001196	30S subunit binding site; other site
749222001197	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
749222001198	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
749222001199	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
749222001200	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
749222001201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222001202	Walker A motif; other site
749222001203	ATP binding site [chemical binding]; other site
749222001204	Walker B motif; other site
749222001205	arginine finger; other site
749222001206	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
749222001207	Response regulator receiver domain; Region: Response_reg; pfam00072
749222001208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222001209	active site
749222001210	phosphorylation site [posttranslational modification]
749222001211	intermolecular recognition site; other site
749222001212	dimerization interface [polypeptide binding]; other site
749222001213	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222001214	dimer interface [polypeptide binding]; other site
749222001215	phosphorylation site [posttranslational modification]
749222001216	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222001217	ATP binding site [chemical binding]; other site
749222001218	Mg2+ binding site [ion binding]; other site
749222001219	G-X-G motif; other site
749222001220	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
749222001221	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222001222	active site
749222001223	phosphorylation site [posttranslational modification]
749222001224	intermolecular recognition site; other site
749222001225	dimerization interface [polypeptide binding]; other site
749222001226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222001227	phosphorylation site [posttranslational modification]
749222001228	intermolecular recognition site; other site
749222001229	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
749222001230	putative binding surface; other site
749222001231	active site
749222001232	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
749222001233	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
749222001234	GIY-YIG motif/motif A; other site
749222001235	active site
749222001236	catalytic site [active]
749222001237	putative DNA binding site [nucleotide binding]; other site
749222001238	metal binding site [ion binding]; metal-binding site
749222001239	UvrB/uvrC motif; Region: UVR; pfam02151
749222001240	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
749222001241	Protein of unknown function (DUF721); Region: DUF721; cl02324
749222001242	L-aspartate oxidase; Provisional; Region: PRK06175
749222001243	L-aspartate oxidase; Provisional; Region: PRK08071
749222001244	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
749222001245	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
749222001246	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
749222001247	GMP synthase; Reviewed; Region: guaA; PRK00074
749222001248	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
749222001249	AMP/PPi binding site [chemical binding]; other site
749222001250	candidate oxyanion hole; other site
749222001251	catalytic triad [active]
749222001252	potential glutamine specificity residues [chemical binding]; other site
749222001253	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
749222001254	ATP Binding subdomain [chemical binding]; other site
749222001255	Ligand Binding sites [chemical binding]; other site
749222001256	Dimerization subdomain; other site
749222001257	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
749222001258	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
749222001259	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
749222001260	homodimer interface [polypeptide binding]; other site
749222001261	substrate-cofactor binding pocket; other site
749222001262	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222001263	catalytic residue [active]
749222001264	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
749222001265	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
749222001266	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
749222001267	Predicted amidohydrolase [General function prediction only]; Region: COG0388
749222001268	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
749222001269	active site
749222001270	catalytic triad [active]
749222001271	dimer interface [polypeptide binding]; other site
749222001272	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
749222001273	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
749222001274	ATP binding site [chemical binding]; other site
749222001275	substrate interface [chemical binding]; other site
749222001276	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
749222001277	homotrimer interaction site [polypeptide binding]; other site
749222001278	putative active site [active]
749222001279	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
749222001280	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
749222001281	GTPase CgtA; Reviewed; Region: obgE; PRK12299
749222001282	GTP1/OBG; Region: GTP1_OBG; pfam01018
749222001283	Obg GTPase; Region: Obg; cd01898
749222001284	G1 box; other site
749222001285	GTP/Mg2+ binding site [chemical binding]; other site
749222001286	Switch I region; other site
749222001287	G2 box; other site
749222001288	G3 box; other site
749222001289	Switch II region; other site
749222001290	G4 box; other site
749222001291	G5 box; other site
749222001292	gamma-glutamyl kinase; Provisional; Region: PRK05429
749222001293	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
749222001294	nucleotide binding site [chemical binding]; other site
749222001295	homotetrameric interface [polypeptide binding]; other site
749222001296	putative phosphate binding site [ion binding]; other site
749222001297	putative allosteric binding site; other site
749222001298	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
749222001299	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
749222001300	putative active site [active]
749222001301	substrate binding site [chemical binding]; other site
749222001302	putative cosubstrate binding site; other site
749222001303	catalytic site [active]
749222001304	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
749222001305	substrate binding site [chemical binding]; other site
749222001306	biotin--protein ligase; Provisional; Region: PRK08477
749222001307	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
749222001308	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
749222001309	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
749222001310	P-loop; other site
749222001311	Magnesium ion binding site [ion binding]; other site
749222001312	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
749222001313	Magnesium ion binding site [ion binding]; other site
749222001314	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
749222001315	ParB-like nuclease domain; Region: ParB; smart00470
749222001316	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
749222001317	F0F1 ATP synthase subunit B; Validated; Region: PRK08475
749222001318	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
749222001319	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
749222001320	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
749222001321	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
749222001322	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
749222001323	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
749222001324	beta subunit interaction interface [polypeptide binding]; other site
749222001325	Walker A motif; other site
749222001326	ATP binding site [chemical binding]; other site
749222001327	Walker B motif; other site
749222001328	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
749222001329	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
749222001330	core domain interface [polypeptide binding]; other site
749222001331	delta subunit interface [polypeptide binding]; other site
749222001332	epsilon subunit interface [polypeptide binding]; other site
749222001333	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
749222001334	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
749222001335	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
749222001336	alpha subunit interaction interface [polypeptide binding]; other site
749222001337	Walker A motif; other site
749222001338	ATP binding site [chemical binding]; other site
749222001339	Walker B motif; other site
749222001340	inhibitor binding site; inhibition site
749222001341	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
749222001342	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
749222001343	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
749222001344	gamma subunit interface [polypeptide binding]; other site
749222001345	epsilon subunit interface [polypeptide binding]; other site
749222001346	LBP interface [polypeptide binding]; other site
749222001347	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
749222001348	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
749222001349	TolR protein; Region: tolR; TIGR02801
749222001350	TonB C terminal; Region: TonB_2; pfam13103
749222001351	MOSC domain; Region: MOSC; pfam03473
749222001352	heat shock protein 90; Provisional; Region: PRK05218
749222001353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222001354	ATP binding site [chemical binding]; other site
749222001355	Mg2+ binding site [ion binding]; other site
749222001356	G-X-G motif; other site
749222001357	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
749222001358	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
749222001359	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
749222001360	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
749222001361	active site
749222001362	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
749222001363	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
749222001364	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
749222001365	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
749222001366	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
749222001367	Organic solvent tolerance protein; Region: OstA_C; pfam04453
749222001368	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
749222001369	HSP70 interaction site [polypeptide binding]; other site
749222001370	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
749222001371	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
749222001372	oligomer interface [polypeptide binding]; other site
749222001373	RNA binding site [nucleotide binding]; other site
749222001374	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
749222001375	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
749222001376	RNase E interface [polypeptide binding]; other site
749222001377	trimer interface [polypeptide binding]; other site
749222001378	active site
749222001379	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
749222001380	putative nucleic acid binding region [nucleotide binding]; other site
749222001381	G-X-X-G motif; other site
749222001382	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
749222001383	RNA binding site [nucleotide binding]; other site
749222001384	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222001385	F0F1 ATP synthase subunit C; Validated; Region: PRK08482
749222001386	Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216
749222001387	IHF dimer interface [polypeptide binding]; other site
749222001388	IHF - DNA interface [nucleotide binding]; other site
749222001389	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
749222001390	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
749222001391	HSP70 interaction site [polypeptide binding]; other site
749222001392	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
749222001393	substrate binding site [polypeptide binding]; other site
749222001394	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
749222001395	Zn binding sites [ion binding]; other site
749222001396	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
749222001397	dimer interface [polypeptide binding]; other site
749222001398	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
749222001399	recombination protein RecR; Reviewed; Region: recR; PRK00076
749222001400	RecR protein; Region: RecR; pfam02132
749222001401	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
749222001402	putative active site [active]
749222001403	putative metal-binding site [ion binding]; other site
749222001404	tetramer interface [polypeptide binding]; other site
749222001405	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
749222001406	Rrf2 family protein; Region: rrf2_super; TIGR00738
749222001407	Transcriptional regulator; Region: Rrf2; pfam02082
749222001408	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
749222001409	16S/18S rRNA binding site [nucleotide binding]; other site
749222001410	S13e-L30e interaction site [polypeptide binding]; other site
749222001411	25S rRNA binding site [nucleotide binding]; other site
749222001412	GrpE; Region: GrpE; pfam01025
749222001413	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
749222001414	dimer interface [polypeptide binding]; other site
749222001415	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
749222001416	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
749222001417	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
749222001418	nucleotide binding site [chemical binding]; other site
749222001419	NEF interaction site [polypeptide binding]; other site
749222001420	SBD interface [polypeptide binding]; other site
749222001421	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
749222001422	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
749222001423	threonine dehydratase; Provisional; Region: PRK08526
749222001424	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
749222001425	tetramer interface [polypeptide binding]; other site
749222001426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222001427	catalytic residue [active]
749222001428	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
749222001429	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
749222001430	exopolyphosphatase; Region: exo_poly_only; TIGR03706
749222001431	nucleotide binding site [chemical binding]; other site
749222001432	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527
749222001433	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
749222001434	PYR/PP interface [polypeptide binding]; other site
749222001435	dimer interface [polypeptide binding]; other site
749222001436	TPP binding site [chemical binding]; other site
749222001437	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
749222001438	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
749222001439	TPP-binding site [chemical binding]; other site
749222001440	dimer interface [polypeptide binding]; other site
749222001441	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
749222001442	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
749222001443	putative valine binding site [chemical binding]; other site
749222001444	dimer interface [polypeptide binding]; other site
749222001445	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
749222001446	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
749222001447	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
749222001448	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
749222001449	trimer interface [polypeptide binding]; other site
749222001450	active site
749222001451	UDP-GlcNAc binding site [chemical binding]; other site
749222001452	lipid binding site [chemical binding]; lipid-binding site
749222001453	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
749222001454	PAS domain; Region: PAS_9; pfam13426
749222001455	putative active site [active]
749222001456	heme pocket [chemical binding]; other site
749222001457	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
749222001458	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
749222001459	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
749222001460	substrate binding pocket [chemical binding]; other site
749222001461	dimer interface [polypeptide binding]; other site
749222001462	inhibitor binding site; inhibition site
749222001463	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
749222001464	B12 binding site [chemical binding]; other site
749222001465	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
749222001466	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
749222001467	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
749222001468	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
749222001469	active site
749222001470	metal binding site [ion binding]; metal-binding site
749222001471	lipid kinase; Reviewed; Region: PRK13054
749222001472	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
749222001473	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815
749222001474	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
749222001475	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
749222001476	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
749222001477	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
749222001478	Mg++ binding site [ion binding]; other site
749222001479	putative catalytic motif [active]
749222001480	putative substrate binding site [chemical binding]; other site
749222001481	phosphoglyceromutase; Provisional; Region: PRK05434
749222001482	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
749222001483	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
749222001484	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
749222001485	NAD(P) binding site [chemical binding]; other site
749222001486	homotetramer interface [polypeptide binding]; other site
749222001487	homodimer interface [polypeptide binding]; other site
749222001488	active site
749222001489	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222001490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222001491	active site
749222001492	phosphorylation site [posttranslational modification]
749222001493	intermolecular recognition site; other site
749222001494	dimerization interface [polypeptide binding]; other site
749222001495	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222001496	DNA binding site [nucleotide binding]
749222001497	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222001498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222001499	ATP binding site [chemical binding]; other site
749222001500	Mg2+ binding site [ion binding]; other site
749222001501	G-X-G motif; other site
749222001502	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222001503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222001504	active site
749222001505	phosphorylation site [posttranslational modification]
749222001506	intermolecular recognition site; other site
749222001507	dimerization interface [polypeptide binding]; other site
749222001508	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
749222001509	DNA binding site [nucleotide binding]
749222001510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222001511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
749222001512	dimer interface [polypeptide binding]; other site
749222001513	phosphorylation site [posttranslational modification]
749222001514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222001515	ATP binding site [chemical binding]; other site
749222001516	Mg2+ binding site [ion binding]; other site
749222001517	G-X-G motif; other site
749222001518	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
749222001519	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
749222001520	Cytochrome c; Region: Cytochrom_C; pfam00034
749222001521	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
749222001522	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
749222001523	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
749222001524	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
749222001525	Cytochrome c; Region: Cytochrom_C; cl11414
749222001526	Cytochrome c; Region: Cytochrom_C; cl11414
749222001527	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
749222001528	4Fe-4S binding domain; Region: Fer4_5; pfam12801
749222001529	4Fe-4S binding domain; Region: Fer4_5; pfam12801
749222001530	4Fe-4S binding domain; Region: Fer4_6; pfam12837
749222001531	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
749222001532	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
749222001533	Walker A/P-loop; other site
749222001534	ATP binding site [chemical binding]; other site
749222001535	Q-loop/lid; other site
749222001536	ABC transporter signature motif; other site
749222001537	Walker B; other site
749222001538	D-loop; other site
749222001539	H-loop/switch region; other site
749222001540	NosL; Region: NosL; cl01769
749222001541	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
749222001542	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
749222001543	NosL; Region: NosL; cl01769
749222001544	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
749222001545	PAS domain; Region: PAS_9; pfam13426
749222001546	putative active site [active]
749222001547	heme pocket [chemical binding]; other site
749222001548	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222001549	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222001550	active site
749222001551	phosphorylation site [posttranslational modification]
749222001552	intermolecular recognition site; other site
749222001553	dimerization interface [polypeptide binding]; other site
749222001554	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222001555	DNA binding site [nucleotide binding]
749222001556	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
749222001557	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
749222001558	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
749222001559	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
749222001560	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
749222001561	N-terminal plug; other site
749222001562	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
749222001563	ligand-binding site [chemical binding]; other site
749222001564	NosL; Region: NosL; cl01769
749222001565	NosL; Region: NosL; cl01769
749222001566	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
749222001567	FtsX-like permease family; Region: FtsX; pfam02687
749222001568	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
749222001569	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
749222001570	Walker A/P-loop; other site
749222001571	ATP binding site [chemical binding]; other site
749222001572	Q-loop/lid; other site
749222001573	ABC transporter signature motif; other site
749222001574	Walker B; other site
749222001575	D-loop; other site
749222001576	H-loop/switch region; other site
749222001577	Family description; Region: DsbD_2; pfam13386
749222001578	acyl carrier protein; Provisional; Region: acpP; PRK00982
749222001579	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439
749222001580	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
749222001581	dimer interface [polypeptide binding]; other site
749222001582	active site
749222001583	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
749222001584	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
749222001585	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
749222001586	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
749222001587	Type III pantothenate kinase; Region: Pan_kinase; cl17198
749222001588	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
749222001589	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
749222001590	Methyltransferase domain; Region: Methyltransf_23; pfam13489
749222001591	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222001592	S-adenosylmethionine binding site [chemical binding]; other site
749222001593	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
749222001594	Methyltransferase domain; Region: Methyltransf_23; pfam13489
749222001595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222001596	S-adenosylmethionine binding site [chemical binding]; other site
749222001597	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
749222001598	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222001599	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
749222001600	dimerization interface [polypeptide binding]; other site
749222001601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222001602	ATP binding site [chemical binding]; other site
749222001603	Mg2+ binding site [ion binding]; other site
749222001604	G-X-G motif; other site
749222001605	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222001606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222001607	active site
749222001608	phosphorylation site [posttranslational modification]
749222001609	intermolecular recognition site; other site
749222001610	dimerization interface [polypeptide binding]; other site
749222001611	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222001612	DNA binding site [nucleotide binding]
749222001613	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
749222001614	Low molecular weight phosphatase family; Region: LMWPc; cd00115
749222001615	active site
749222001616	Predicted permeases [General function prediction only]; Region: COG0701
749222001617	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
749222001618	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
749222001619	catalytic residues [active]
749222001620	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
749222001621	putative DNA binding site [nucleotide binding]; other site
749222001622	putative Zn2+ binding site [ion binding]; other site
749222001623	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
749222001624	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
749222001625	Nitrate and nitrite sensing; Region: NIT; pfam08376
749222001626	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222001627	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222001628	dimer interface [polypeptide binding]; other site
749222001629	phosphorylation site [posttranslational modification]
749222001630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222001631	ATP binding site [chemical binding]; other site
749222001632	Mg2+ binding site [ion binding]; other site
749222001633	G-X-G motif; other site
749222001634	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
749222001635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222001636	active site
749222001637	phosphorylation site [posttranslational modification]
749222001638	intermolecular recognition site; other site
749222001639	dimerization interface [polypeptide binding]; other site
749222001640	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
749222001641	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
749222001642	Walker A/P-loop; other site
749222001643	ATP binding site [chemical binding]; other site
749222001644	Q-loop/lid; other site
749222001645	ABC transporter signature motif; other site
749222001646	Walker B; other site
749222001647	D-loop; other site
749222001648	H-loop/switch region; other site
749222001649	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
749222001650	FtsX-like permease family; Region: FtsX; pfam02687
749222001651	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
749222001652	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
749222001653	E3 interaction surface; other site
749222001654	lipoyl attachment site [posttranslational modification]; other site
749222001655	HlyD family secretion protein; Region: HlyD_3; pfam13437
749222001656	Ion channel; Region: Ion_trans_2; pfam07885
749222001657	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
749222001658	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
749222001659	catalytic residues [active]
749222001660	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
749222001661	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
749222001662	heme-binding site [chemical binding]; other site
749222001663	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
749222001664	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
749222001665	ligand binding site [chemical binding]; other site
749222001666	flexible hinge region; other site
749222001667	Ion channel; Region: Ion_trans_2; pfam07885
749222001668	TrkA-N domain; Region: TrkA_N; pfam02254
749222001669	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
749222001670	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
749222001671	Chromate transporter; Region: Chromate_transp; pfam02417
749222001672	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
749222001673	Chromate transporter; Region: Chromate_transp; pfam02417
749222001674	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
749222001675	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
749222001676	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
749222001677	active site residue [active]
749222001678	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
749222001679	active site residue [active]
749222001680	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
749222001681	active site
749222001682	NTP binding site [chemical binding]; other site
749222001683	metal binding triad [ion binding]; metal-binding site
749222001684	antibiotic binding site [chemical binding]; other site
749222001685	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
749222001686	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
749222001687	Protein export membrane protein; Region: SecD_SecF; cl14618
749222001688	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
749222001689	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
749222001690	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
749222001691	E3 interaction surface; other site
749222001692	lipoyl attachment site [posttranslational modification]; other site
749222001693	Outer membrane efflux protein; Region: OEP; pfam02321
749222001694	Outer membrane efflux protein; Region: OEP; pfam02321
749222001695	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
749222001696	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
749222001697	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
749222001698	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
749222001699	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
749222001700	glutaminase active site [active]
749222001701	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
749222001702	dimer interface [polypeptide binding]; other site
749222001703	active site
749222001704	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
749222001705	dimer interface [polypeptide binding]; other site
749222001706	active site
749222001707	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
749222001708	metal binding triad; other site
749222001709	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
749222001710	UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844
749222001711	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
749222001712	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
749222001713	hypothetical protein; Provisional; Region: PRK08444
749222001714	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222001715	FeS/SAM binding site; other site
749222001716	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
749222001717	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
749222001718	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
749222001719	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
749222001720	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
749222001721	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
749222001722	glutamine binding [chemical binding]; other site
749222001723	catalytic triad [active]
749222001724	ATP citrate (pro-S)-lyase; Region: PLN02235
749222001725	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
749222001726	ATP citrate (pro-S)-lyase; Region: PLN02522
749222001727	CoA-ligase; Region: Ligase_CoA; pfam00549
749222001728	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
749222001729	active site
749222001730	oxalacetate binding site [chemical binding]; other site
749222001731	citrylCoA binding site [chemical binding]; other site
749222001732	coenzyme A binding site [chemical binding]; other site
749222001733	catalytic triad [active]
749222001734	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
749222001735	Sel1-like repeats; Region: SEL1; smart00671
749222001736	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222001737	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
749222001738	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
749222001739	putative dimer interface [polypeptide binding]; other site
749222001740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
749222001741	Major Facilitator Superfamily; Region: MFS_1; pfam07690
749222001742	putative substrate translocation pore; other site
749222001743	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
749222001744	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
749222001745	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
749222001746	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
749222001747	metal binding site [ion binding]; metal-binding site
749222001748	HflC protein; Region: hflC; TIGR01932
749222001749	SPFH domain / Band 7 family; Region: Band_7; pfam01145
749222001750	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
749222001751	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
749222001752	homodimer interface [polypeptide binding]; other site
749222001753	substrate-cofactor binding pocket; other site
749222001754	catalytic residue [active]
749222001755	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
749222001756	PAS domain; Region: PAS_9; pfam13426
749222001757	putative active site [active]
749222001758	heme pocket [chemical binding]; other site
749222001759	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
749222001760	MutS domain I; Region: MutS_I; pfam01624
749222001761	MutS domain III; Region: MutS_III; pfam05192
749222001762	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222001763	Walker A/P-loop; other site
749222001764	ATP binding site [chemical binding]; other site
749222001765	Q-loop/lid; other site
749222001766	ABC transporter signature motif; other site
749222001767	Walker B; other site
749222001768	D-loop; other site
749222001769	H-loop/switch region; other site
749222001770	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
749222001771	active site
749222001772	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
749222001773	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
749222001774	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
749222001775	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
749222001776	putative active site [active]
749222001777	putative substrate binding site [chemical binding]; other site
749222001778	putative cosubstrate binding site; other site
749222001779	catalytic site [active]
749222001780	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
749222001781	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
749222001782	S1 domain; Region: S1_2; pfam13509
749222001783	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
749222001784	phosphoglycolate phosphatase; Provisional; Region: PRK13222
749222001785	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
749222001786	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222001787	motif II; other site
749222001788	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
749222001789	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879
749222001790	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
749222001791	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
749222001792	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
749222001793	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
749222001794	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
749222001795	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
749222001796	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
749222001797	putative active site [active]
749222001798	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
749222001799	cyclase homology domain; Region: CHD; cd07302
749222001800	nucleotidyl binding site; other site
749222001801	metal binding site [ion binding]; metal-binding site
749222001802	dimer interface [polypeptide binding]; other site
749222001803	multifunctional aminopeptidase A; Provisional; Region: PRK00913
749222001804	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
749222001805	interface (dimer of trimers) [polypeptide binding]; other site
749222001806	Substrate-binding/catalytic site; other site
749222001807	Zn-binding sites [ion binding]; other site
749222001808	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
749222001809	four helix bundle protein; Region: TIGR02436
749222001810	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
749222001811	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
749222001812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222001813	catalytic residue [active]
749222001814	YceG-like family; Region: YceG; pfam02618
749222001815	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
749222001816	dimerization interface [polypeptide binding]; other site
749222001817	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
749222001818	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
749222001819	substrate binding site [chemical binding]; other site
749222001820	tartrate dehydrogenase; Region: TTC; TIGR02089
749222001821	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
749222001822	Transposase IS200 like; Region: Y1_Tnp; cl00848
749222001823	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
749222001824	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
749222001825	active site
749222001826	NTP binding site [chemical binding]; other site
749222001827	metal binding triad [ion binding]; metal-binding site
749222001828	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
749222001829	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
749222001830	active site
749222001831	nucleophile elbow; other site
749222001832	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
749222001833	TrkA-N domain; Region: TrkA_N; pfam02254
749222001834	TrkA-C domain; Region: TrkA_C; pfam02080
749222001835	TrkA-N domain; Region: TrkA_N; pfam02254
749222001836	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
749222001837	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
749222001838	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
749222001839	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
749222001840	metal binding site [ion binding]; metal-binding site
749222001841	putative dimer interface [polypeptide binding]; other site
749222001842	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
749222001843	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
749222001844	ABC-ATPase subunit  interface; other site
749222001845	dimer interface [polypeptide binding]; other site
749222001846	putative PBP binding regions; other site
749222001847	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
749222001848	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
749222001849	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
749222001850	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
749222001851	putative metal binding residues [ion binding]; other site
749222001852	Competence-damaged protein; Region: CinA; pfam02464
749222001853	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
749222001854	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
749222001855	active site
749222001856	tetramer interface; other site
749222001857	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
749222001858	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
749222001859	active site
749222001860	HIGH motif; other site
749222001861	nucleotide binding site [chemical binding]; other site
749222001862	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
749222001863	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
749222001864	active site
749222001865	KMSKS motif; other site
749222001866	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
749222001867	tRNA binding surface [nucleotide binding]; other site
749222001868	anticodon binding site; other site
749222001869	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
749222001870	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
749222001871	NlpC/P60 family; Region: NLPC_P60; pfam00877
749222001872	Sporulation related domain; Region: SPOR; pfam05036
749222001873	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
749222001874	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
749222001875	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
749222001876	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
749222001877	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
749222001878	coproporphyrinogen III oxidase; Provisional; Region: PRK08446
749222001879	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222001880	FeS/SAM binding site; other site
749222001881	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
749222001882	putative active site [active]
749222001883	Ap4A binding site [chemical binding]; other site
749222001884	nudix motif; other site
749222001885	putative metal binding site [ion binding]; other site
749222001886	aspartate kinase; Reviewed; Region: PRK06635
749222001887	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
749222001888	putative nucleotide binding site [chemical binding]; other site
749222001889	putative catalytic residues [active]
749222001890	putative Mg ion binding site [ion binding]; other site
749222001891	putative aspartate binding site [chemical binding]; other site
749222001892	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
749222001893	putative allosteric regulatory site; other site
749222001894	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
749222001895	DNA replication regulator; Region: HobA; pfam12163
749222001896	DNA polymerase III subunit delta'; Validated; Region: PRK08485
749222001897	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
749222001898	dihydropteroate synthase; Region: DHPS; TIGR01496
749222001899	substrate binding pocket [chemical binding]; other site
749222001900	dimer interface [polypeptide binding]; other site
749222001901	inhibitor binding site; inhibition site
749222001902	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
749222001903	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
749222001904	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
749222001905	DsrE/DsrF-like family; Region: DrsE; cl00672
749222001906	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
749222001907	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
749222001908	nucleotide binding pocket [chemical binding]; other site
749222001909	K-X-D-G motif; other site
749222001910	catalytic site [active]
749222001911	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
749222001912	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
749222001913	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
749222001914	Dimer interface [polypeptide binding]; other site
749222001915	BRCT sequence motif; other site
749222001916	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
749222001917	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
749222001918	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222001919	Walker A/P-loop; other site
749222001920	ATP binding site [chemical binding]; other site
749222001921	Q-loop/lid; other site
749222001922	ABC transporter signature motif; other site
749222001923	Walker B; other site
749222001924	D-loop; other site
749222001925	H-loop/switch region; other site
749222001926	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
749222001927	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
749222001928	active site
749222001929	HIGH motif; other site
749222001930	dimer interface [polypeptide binding]; other site
749222001931	KMSKS motif; other site
749222001932	GTP-binding protein Der; Reviewed; Region: PRK00093
749222001933	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
749222001934	G1 box; other site
749222001935	GTP/Mg2+ binding site [chemical binding]; other site
749222001936	Switch I region; other site
749222001937	G2 box; other site
749222001938	Switch II region; other site
749222001939	G3 box; other site
749222001940	G4 box; other site
749222001941	G5 box; other site
749222001942	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
749222001943	G1 box; other site
749222001944	GTP/Mg2+ binding site [chemical binding]; other site
749222001945	Switch I region; other site
749222001946	G2 box; other site
749222001947	G3 box; other site
749222001948	Switch II region; other site
749222001949	G4 box; other site
749222001950	G5 box; other site
749222001951	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
749222001952	Mechanosensitive ion channel; Region: MS_channel; pfam00924
749222001953	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
749222001954	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
749222001955	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
749222001956	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
749222001957	homopentamer interface [polypeptide binding]; other site
749222001958	active site
749222001959	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
749222001960	putative RNA binding site [nucleotide binding]; other site
749222001961	hypothetical protein; Provisional; Region: PRK08445
749222001962	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222001963	FeS/SAM binding site; other site
749222001964	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
749222001965	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
749222001966	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
749222001967	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
749222001968	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
749222001969	generic binding surface II; other site
749222001970	ssDNA binding site; other site
749222001971	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
749222001972	ATP binding site [chemical binding]; other site
749222001973	putative Mg++ binding site [ion binding]; other site
749222001974	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
749222001975	nucleotide binding region [chemical binding]; other site
749222001976	ATP-binding site [chemical binding]; other site
749222001977	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
749222001978	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
749222001979	putative DNA binding helix; other site
749222001980	Integrase core domain; Region: rve; pfam00665
749222001981	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
749222001982	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
749222001983	molybdopterin cofactor binding site; other site
749222001984	Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568
749222001985	molybdopterin cofactor binding site; other site
749222001986	hypothetical protein; Reviewed; Region: PRK12497
749222001987	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
749222001988	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
749222001989	metal binding site [ion binding]; metal-binding site
749222001990	active site
749222001991	I-site; other site
749222001992	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
749222001993	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
749222001994	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
749222001995	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
749222001996	catalytic residues [active]
749222001997	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
749222001998	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
749222001999	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
749222002000	dihydrodipicolinate reductase; Provisional; Region: PRK00048
749222002001	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
749222002002	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
749222002003	amidophosphoribosyltransferase; Provisional; Region: PRK08525
749222002004	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
749222002005	active site
749222002006	tetramer interface [polypeptide binding]; other site
749222002007	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
749222002008	active site
749222002009	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
749222002010	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222002011	Protein of unknown function (DUF505); Region: DUF505; pfam04458
749222002012	acid-resistance membrane protein; Provisional; Region: PRK10209
749222002013	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
749222002014	Domain of unknown function (DUF1931); Region: DUF1931; pfam09123
749222002015	YfdX protein; Region: YfdX; pfam10938
749222002016	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
749222002017	AzlC protein; Region: AzlC; cl00570
749222002018	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
749222002019	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
749222002020	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
749222002021	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
749222002022	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
749222002023	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
749222002024	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
749222002025	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
749222002026	glutamine synthetase, type I; Region: GlnA; TIGR00653
749222002027	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
749222002028	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
749222002029	histidinol-phosphatase; Provisional; Region: PRK07328
749222002030	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
749222002031	active site
749222002032	dimer interface [polypeptide binding]; other site
749222002033	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
749222002034	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
749222002035	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
749222002036	shikimate binding site; other site
749222002037	NAD(P) binding site [chemical binding]; other site
749222002038	PemK-like protein; Region: PemK; pfam02452
749222002039	Putative catalytic NodB homology domain of uncharacterized protein RC0012 from Rickettsia conorii and its bacterial homologs; Region: CE4_RC0012_like; cd10963
749222002040	NodB motif; other site
749222002041	putative active site [active]
749222002042	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
749222002043	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
749222002044	Peptidase family U32; Region: Peptidase_U32; pfam01136
749222002045	metal binding site [ion binding]; metal-binding site
749222002046	AIR carboxylase; Region: AIRC; smart01001
749222002047	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
749222002048	catalytic residues [active]
749222002049	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
749222002050	dimer interface [polypeptide binding]; other site
749222002051	motif 1; other site
749222002052	active site
749222002053	motif 2; other site
749222002054	motif 3; other site
749222002055	Uncharacterized conserved protein [Function unknown]; Region: COG0327
749222002056	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
749222002057	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
749222002058	Putative zinc ribbon domain; Region: DUF164; pfam02591
749222002059	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
749222002060	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
749222002061	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
749222002062	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
749222002063	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
749222002064	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
749222002065	active site
749222002066	signal recognition particle protein; Provisional; Region: PRK10867
749222002067	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
749222002068	P loop; other site
749222002069	GTP binding site [chemical binding]; other site
749222002070	RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570
749222002071	catalytic residue [active]
749222002072	Signal peptide binding domain; Region: SRP_SPB; pfam02978
749222002073	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
749222002074	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
749222002075	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
749222002076	thiamine phosphate binding site [chemical binding]; other site
749222002077	active site
749222002078	pyrophosphate binding site [ion binding]; other site
749222002079	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
749222002080	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
749222002081	GatB domain; Region: GatB_Yqey; smart00845
749222002082	Ion transport protein; Region: Ion_trans; pfam00520
749222002083	Ion channel; Region: Ion_trans_2; pfam07885
749222002084	TrkA-N domain; Region: TrkA_N; pfam02254
749222002085	TrkA-C domain; Region: TrkA_C; pfam02080
749222002086	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
749222002087	TrkA-N domain; Region: TrkA_N; pfam02254
749222002088	TrkA-C domain; Region: TrkA_C; pfam02080
749222002089	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
749222002090	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
749222002091	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
749222002092	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
749222002093	GTPase Era; Reviewed; Region: era; PRK00089
749222002094	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
749222002095	G1 box; other site
749222002096	GTP/Mg2+ binding site [chemical binding]; other site
749222002097	Switch I region; other site
749222002098	G2 box; other site
749222002099	Switch II region; other site
749222002100	G3 box; other site
749222002101	G4 box; other site
749222002102	G5 box; other site
749222002103	KH domain; Region: KH_2; pfam07650
749222002104	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
749222002105	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
749222002106	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
749222002107	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
749222002108	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
749222002109	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222002110	AAA domain; Region: AAA_22; pfam13401
749222002111	Walker A motif; other site
749222002112	ATP binding site [chemical binding]; other site
749222002113	Walker B motif; other site
749222002114	arginine finger; other site
749222002115	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
749222002116	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
749222002117	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
749222002118	Walker A motif; other site
749222002119	ATP binding site [chemical binding]; other site
749222002120	Walker B motif; other site
749222002121	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
749222002122	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
749222002123	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
749222002124	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
749222002125	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
749222002126	Ligand binding site; other site
749222002127	oligomer interface; other site
749222002128	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
749222002129	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
749222002130	purine monophosphate binding site [chemical binding]; other site
749222002131	dimer interface [polypeptide binding]; other site
749222002132	putative catalytic residues [active]
749222002133	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
749222002134	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
749222002135	chaperone protein DnaJ; Provisional; Region: PRK14299
749222002136	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
749222002137	HSP70 interaction site [polypeptide binding]; other site
749222002138	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
749222002139	substrate binding site [polypeptide binding]; other site
749222002140	dimer interface [polypeptide binding]; other site
749222002141	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
749222002142	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
749222002143	DNA binding residues [nucleotide binding]
749222002144	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
749222002145	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
749222002146	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
749222002147	putative catalytic site [active]
749222002148	putative metal binding site [ion binding]; other site
749222002149	putative phosphate binding site [ion binding]; other site
749222002150	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
749222002151	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
749222002152	dimer interface [polypeptide binding]; other site
749222002153	substrate binding site [chemical binding]; other site
749222002154	metal binding sites [ion binding]; metal-binding site
749222002155	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
749222002156	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
749222002157	Mechanosensitive ion channel; Region: MS_channel; pfam00924
749222002158	Cytochrome c; Region: Cytochrom_C; cl11414
749222002159	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
749222002160	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
749222002161	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
749222002162	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
749222002163	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
749222002164	active site
749222002165	metal-binding site [ion binding]
749222002166	nucleotide-binding site [chemical binding]; other site
749222002167	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
749222002168	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
749222002169	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
749222002170	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
749222002171	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
749222002172	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
749222002173	RuvA N terminal domain; Region: RuvA_N; pfam01330
749222002174	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
749222002175	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
749222002176	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
749222002177	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
749222002178	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
749222002179	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
749222002180	inhibitor-cofactor binding pocket; inhibition site
749222002181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222002182	catalytic residue [active]
749222002183	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
749222002184	trimerization site [polypeptide binding]; other site
749222002185	active site
749222002186	Glutamyl-tRNA reductase [Coenzyme metabolism]; Region: HemA; COG0373
749222002187	phosphatidylserine decarboxylase; Provisional; Region: PRK03934
749222002188	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
749222002189	Cache domain; Region: Cache_1; pfam02743
749222002190	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
749222002191	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
749222002192	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222002193	motif II; other site
749222002194	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
749222002195	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
749222002196	BRO family, N-terminal domain; Region: Bro-N; cl10591
749222002197	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
749222002198	Fic/DOC family; Region: Fic; pfam02661
749222002199	phosphate acetyltransferase; Reviewed; Region: PRK05632
749222002200	DRTGG domain; Region: DRTGG; pfam07085
749222002201	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
749222002202	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
749222002203	propionate/acetate kinase; Provisional; Region: PRK12379
749222002204	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
749222002205	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
749222002206	non-specific DNA binding site [nucleotide binding]; other site
749222002207	salt bridge; other site
749222002208	sequence-specific DNA binding site [nucleotide binding]; other site
749222002209	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
749222002210	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
749222002211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
749222002212	dimer interface [polypeptide binding]; other site
749222002213	conserved gate region; other site
749222002214	putative PBP binding loops; other site
749222002215	ABC-ATPase subunit interface; other site
749222002216	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
749222002217	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222002218	S-adenosylmethionine binding site [chemical binding]; other site
749222002219	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
749222002220	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
749222002221	active site clefts [active]
749222002222	zinc binding site [ion binding]; other site
749222002223	dimer interface [polypeptide binding]; other site
749222002224	Phosphagen (guanidino) kinases mostly found in eukaryotes; Region: eukaryotic_phosphagen_kinases; cd07931
749222002225	phosphagen binding site; other site
749222002226	ADP binding site [chemical binding]; other site
749222002227	substrate specificity loop; other site
749222002228	active site
749222002229	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
749222002230	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
749222002231	Nuclease-related domain; Region: NERD; pfam08378
749222002232	putative transposase OrfB; Reviewed; Region: PHA02517
749222002233	HTH-like domain; Region: HTH_21; pfam13276
749222002234	Integrase core domain; Region: rve; pfam00665
749222002235	Integrase core domain; Region: rve_3; pfam13683
749222002236	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
749222002237	Transposase; Region: HTH_Tnp_1; cl17663
749222002238	2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633
749222002239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
749222002240	putative substrate translocation pore; other site
749222002241	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
749222002242	putative acyl-acceptor binding pocket; other site
749222002243	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
749222002244	acyl-activating enzyme (AAE) consensus motif; other site
749222002245	AMP binding site [chemical binding]; other site
749222002246	active site
749222002247	CoA binding site [chemical binding]; other site
749222002248	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
749222002249	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
749222002250	DNA binding residues [nucleotide binding]
749222002251	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
749222002252	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
749222002253	IHF dimer interface [polypeptide binding]; other site
749222002254	IHF - DNA interface [nucleotide binding]; other site
749222002255	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
749222002256	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
749222002257	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
749222002258	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
749222002259	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
749222002260	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
749222002261	substrate binding site [chemical binding]; other site
749222002262	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
749222002263	substrate binding site [chemical binding]; other site
749222002264	ligand binding site [chemical binding]; other site
749222002265	SAP domain; Region: SAP; pfam02037
749222002266	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
749222002267	NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912
749222002268	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
749222002269	NlpC/P60 family; Region: NLPC_P60; cl17555
749222002270	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
749222002271	RmuC family; Region: RmuC; pfam02646
749222002272	Predicted transcriptional regulators [Transcription]; Region: COG1733
749222002273	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
749222002274	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
749222002275	Isochorismatase family; Region: Isochorismatase; pfam00857
749222002276	catalytic triad [active]
749222002277	conserved cis-peptide bond; other site
749222002278	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
749222002279	HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3
749222002280	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222002281	active site
749222002282	motif I; other site
749222002283	motif II; other site
749222002284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222002285	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
749222002286	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
749222002287	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
749222002288	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
749222002289	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
749222002290	Ligand Binding Site [chemical binding]; other site
749222002291	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
749222002292	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
749222002293	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
749222002294	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
749222002295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222002296	S-adenosylmethionine binding site [chemical binding]; other site
749222002297	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
749222002298	Region in Clathrin and VPS; Region: Clathrin; pfam00637
749222002299	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
749222002300	active site
749222002301	ribulose/triose binding site [chemical binding]; other site
749222002302	phosphate binding site [ion binding]; other site
749222002303	substrate (anthranilate) binding pocket [chemical binding]; other site
749222002304	product (indole) binding pocket [chemical binding]; other site
749222002305	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
749222002306	metal binding triad [ion binding]; metal-binding site
749222002307	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
749222002308	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
749222002309	CAS motifs; other site
749222002310	active site
749222002311	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
749222002312	Right handed beta helix region; Region: Beta_helix; pfam13229
749222002313	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
749222002314	Pectate lyase; Region: Pec_lyase_C; cl01593
749222002315	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
749222002316	EamA-like transporter family; Region: EamA; pfam00892
749222002317	EamA-like transporter family; Region: EamA; pfam00892
749222002318	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
749222002319	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
749222002320	Walker A/P-loop; other site
749222002321	ATP binding site [chemical binding]; other site
749222002322	Q-loop/lid; other site
749222002323	ABC transporter signature motif; other site
749222002324	Walker B; other site
749222002325	D-loop; other site
749222002326	H-loop/switch region; other site
749222002327	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
749222002328	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
749222002329	Walker A/P-loop; other site
749222002330	ATP binding site [chemical binding]; other site
749222002331	Q-loop/lid; other site
749222002332	ABC transporter signature motif; other site
749222002333	Walker B; other site
749222002334	D-loop; other site
749222002335	H-loop/switch region; other site
749222002336	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
749222002337	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
749222002338	TM-ABC transporter signature motif; other site
749222002339	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
749222002340	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
749222002341	TM-ABC transporter signature motif; other site
749222002342	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
749222002343	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
749222002344	putative ligand binding site [chemical binding]; other site
749222002345	Yqey-like protein; Region: YqeY; pfam09424
749222002346	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
749222002347	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
749222002348	metal binding site [ion binding]; metal-binding site
749222002349	dimer interface [polypeptide binding]; other site
749222002350	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
749222002351	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
749222002352	ATP binding site [chemical binding]; other site
749222002353	Mg2+ binding site [ion binding]; other site
749222002354	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
749222002355	Coenzyme A binding pocket [chemical binding]; other site
749222002356	methionine sulfoxide reductase B; Provisional; Region: PRK00222
749222002357	SelR domain; Region: SelR; pfam01641
749222002358	TPR repeat; Region: TPR_11; pfam13414
749222002359	TPR repeat; Region: TPR_11; pfam13414
749222002360	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
749222002361	binding surface
749222002362	TPR motif; other site
749222002363	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
749222002364	ArsC family; Region: ArsC; pfam03960
749222002365	catalytic residues [active]
749222002366	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
749222002367	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
749222002368	ligand binding site [chemical binding]; other site
749222002369	flexible hinge region; other site
749222002370	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
749222002371	putative switch regulator; other site
749222002372	non-specific DNA interactions [nucleotide binding]; other site
749222002373	DNA binding site [nucleotide binding]
749222002374	sequence specific DNA binding site [nucleotide binding]; other site
749222002375	putative cAMP binding site [chemical binding]; other site
749222002376	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
749222002377	active site
749222002378	Zn binding site [ion binding]; other site
749222002379	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
749222002380	MoxR-like ATPases [General function prediction only]; Region: COG0714
749222002381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222002382	Walker A motif; other site
749222002383	ATP binding site [chemical binding]; other site
749222002384	Walker B motif; other site
749222002385	arginine finger; other site
749222002386	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
749222002387	Protein of unknown function DUF58; Region: DUF58; pfam01882
749222002388	von Willebrand factor type A domain; Region: VWA_2; pfam13519
749222002389	metal ion-dependent adhesion site (MIDAS); other site
749222002390	von Willebrand factor type A domain; Region: VWA_2; pfam13519
749222002391	metal ion-dependent adhesion site (MIDAS); other site
749222002392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
749222002393	TPR motif; other site
749222002394	binding surface
749222002395	Tetratricopeptide repeat; Region: TPR_16; pfam13432
749222002396	Oxygen tolerance; Region: BatD; pfam13584
749222002397	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
749222002398	active site residue [active]
749222002399	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
749222002400	active site residue [active]
749222002401	PcfJ-like protein; Region: PcfJ; pfam14284
749222002402	Transposase IS200 like; Region: Y1_Tnp; pfam01797
749222002403	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
749222002404	active site
749222002405	NTP binding site [chemical binding]; other site
749222002406	metal binding triad [ion binding]; metal-binding site
749222002407	antibiotic binding site [chemical binding]; other site
749222002408	Protein of unknown function DUF86; Region: DUF86; pfam01934
749222002409	PIF1-like helicase; Region: PIF1; pfam05970
749222002410	AAA domain; Region: AAA_30; pfam13604
749222002411	Helicase; Region: Herpes_Helicase; pfam02689
749222002412	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
749222002413	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
749222002414	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
749222002415	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
749222002416	FMN binding site [chemical binding]; other site
749222002417	active site
749222002418	catalytic residues [active]
749222002419	substrate binding site [chemical binding]; other site
749222002420	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
749222002421	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
749222002422	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
749222002423	DNA-binding site [nucleotide binding]; DNA binding site
749222002424	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
749222002425	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222002426	homodimer interface [polypeptide binding]; other site
749222002427	catalytic residue [active]
749222002428	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
749222002429	active site
749222002430	NTP binding site [chemical binding]; other site
749222002431	metal binding triad [ion binding]; metal-binding site
749222002432	antibiotic binding site [chemical binding]; other site
749222002433	Uncharacterized conserved protein [Function unknown]; Region: COG2445
749222002434	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
749222002435	exodeoxyribonuclease X; Provisional; Region: PRK07983
749222002436	active site
749222002437	catalytic site [active]
749222002438	substrate binding site [chemical binding]; other site
749222002439	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
749222002440	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
749222002441	RNA binding surface [nucleotide binding]; other site
749222002442	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
749222002443	active site
749222002444	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
749222002445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222002446	S-adenosylmethionine binding site [chemical binding]; other site
749222002447	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
749222002448	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
749222002449	Walker A/P-loop; other site
749222002450	ATP binding site [chemical binding]; other site
749222002451	Q-loop/lid; other site
749222002452	ABC transporter signature motif; other site
749222002453	Walker B; other site
749222002454	D-loop; other site
749222002455	H-loop/switch region; other site
749222002456	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
749222002457	Peptidase family M23; Region: Peptidase_M23; pfam01551
749222002458	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
749222002459	putative nucleotide binding site [chemical binding]; other site
749222002460	uridine monophosphate binding site [chemical binding]; other site
749222002461	homohexameric interface [polypeptide binding]; other site
749222002462	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
749222002463	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
749222002464	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
749222002465	Zn2+ binding site [ion binding]; other site
749222002466	Mg2+ binding site [ion binding]; other site
749222002467	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
749222002468	synthetase active site [active]
749222002469	NTP binding site [chemical binding]; other site
749222002470	metal binding site [ion binding]; metal-binding site
749222002471	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
749222002472	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
749222002473	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
749222002474	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
749222002475	active site
749222002476	HIGH motif; other site
749222002477	dimer interface [polypeptide binding]; other site
749222002478	KMSKS motif; other site
749222002479	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
749222002480	RNA binding surface [nucleotide binding]; other site
749222002481	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
749222002482	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
749222002483	FMN binding site [chemical binding]; other site
749222002484	substrate binding site [chemical binding]; other site
749222002485	putative catalytic residue [active]
749222002486	AMIN domain; Region: AMIN; pfam11741
749222002487	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
749222002488	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
749222002489	active site
749222002490	metal binding site [ion binding]; metal-binding site
749222002491	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
749222002492	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
749222002493	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
749222002494	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
749222002495	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
749222002496	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
749222002497	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
749222002498	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222002499	motif II; other site
749222002500	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
749222002501	Predicted membrane protein [Function unknown]; Region: COG3174
749222002502	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
749222002503	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
749222002504	NAD-dependent deacetylase; Provisional; Region: PRK00481
749222002505	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
749222002506	NAD+ binding site [chemical binding]; other site
749222002507	substrate binding site [chemical binding]; other site
749222002508	Zn binding site [ion binding]; other site
749222002509	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
749222002510	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
749222002511	CcdB protein; Region: CcdB; cl03380
749222002512	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
749222002513	hypothetical protein; Provisional; Region: PRK10621
749222002514	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
749222002515	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; pfam02943
749222002516	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
749222002517	active site residue [active]
749222002518	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
749222002519	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
749222002520	Family description; Region: DsbD_2; pfam13386
749222002521	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
749222002522	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
749222002523	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
749222002524	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
749222002525	catalytic residues [active]
749222002526	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
749222002527	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
749222002528	active site
749222002529	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
749222002530	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
749222002531	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
749222002532	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
749222002533	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
749222002534	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
749222002535	catalytic residue [active]
749222002536	putative FPP diphosphate  binding site; other site
749222002537	putative FPP binding hydrophobic cleft; other site
749222002538	dimer interface [polypeptide binding]; other site
749222002539	putative IPP diphosphate binding site; other site
749222002540	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
749222002541	Flavoprotein; Region: Flavoprotein; pfam02441
749222002542	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
749222002543	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359
749222002544	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
749222002545	Substrate binding site; other site
749222002546	Mg++ binding site; other site
749222002547	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
749222002548	active site
749222002549	substrate binding site [chemical binding]; other site
749222002550	CoA binding site [chemical binding]; other site
749222002551	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
749222002552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222002553	S-adenosylmethionine binding site [chemical binding]; other site
749222002554	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
749222002555	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
749222002556	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
749222002557	Permutation of conserved domain; other site
749222002558	active site
749222002559	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
749222002560	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
749222002561	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
749222002562	nucleoside/Zn binding site; other site
749222002563	dimer interface [polypeptide binding]; other site
749222002564	catalytic motif [active]
749222002565	hypothetical protein; Reviewed; Region: PRK00024
749222002566	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
749222002567	MPN+ (JAMM) motif; other site
749222002568	Zinc-binding site [ion binding]; other site
749222002569	Domain of unknown function (DUF2018); Region: DUF2018; pfam09442
749222002570	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
749222002571	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
749222002572	substrate binding pocket [chemical binding]; other site
749222002573	chain length determination region; other site
749222002574	substrate-Mg2+ binding site; other site
749222002575	catalytic residues [active]
749222002576	aspartate-rich region 1; other site
749222002577	active site lid residues [active]
749222002578	aspartate-rich region 2; other site
749222002579	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
749222002580	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
749222002581	tRNA; other site
749222002582	putative tRNA binding site [nucleotide binding]; other site
749222002583	putative NADP binding site [chemical binding]; other site
749222002584	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
749222002585	prolyl-tRNA synthetase; Provisional; Region: PRK09194
749222002586	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
749222002587	dimer interface [polypeptide binding]; other site
749222002588	motif 1; other site
749222002589	active site
749222002590	motif 2; other site
749222002591	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
749222002592	putative deacylase active site [active]
749222002593	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
749222002594	active site
749222002595	motif 3; other site
749222002596	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
749222002597	anticodon binding site; other site
749222002598	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
749222002599	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
749222002600	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
749222002601	catalytic residues [active]
749222002602	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
749222002603	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
749222002604	domain interfaces; other site
749222002605	active site
749222002606	adenylate kinase; Reviewed; Region: adk; PRK00279
749222002607	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
749222002608	AMP-binding site [chemical binding]; other site
749222002609	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
749222002610	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
749222002611	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
749222002612	dimer interface [polypeptide binding]; other site
749222002613	anticodon binding site; other site
749222002614	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
749222002615	homodimer interface [polypeptide binding]; other site
749222002616	motif 1; other site
749222002617	active site
749222002618	motif 2; other site
749222002619	GAD domain; Region: GAD; pfam02938
749222002620	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
749222002621	active site
749222002622	motif 3; other site
749222002623	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
749222002624	active site
749222002625	HAMP domain; Region: HAMP; pfam00672
749222002626	dimerization interface [polypeptide binding]; other site
749222002627	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
749222002628	NAD synthetase; Reviewed; Region: nadE; PRK02628
749222002629	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
749222002630	multimer interface [polypeptide binding]; other site
749222002631	active site
749222002632	catalytic triad [active]
749222002633	protein interface 1 [polypeptide binding]; other site
749222002634	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
749222002635	homodimer interface [polypeptide binding]; other site
749222002636	NAD binding pocket [chemical binding]; other site
749222002637	ATP binding pocket [chemical binding]; other site
749222002638	Mg binding site [ion binding]; other site
749222002639	active-site loop [active]
749222002640	Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695
749222002641	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
749222002642	nudix motif; other site
749222002643	TrkA-N domain; Region: TrkA_N; pfam02254
749222002644	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
749222002645	TrkA-N domain; Region: TrkA_N; pfam02254
749222002646	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
749222002647	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
749222002648	7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416
749222002649	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
749222002650	putative NAD(P) binding site [chemical binding]; other site
749222002651	active site
749222002652	dihydrodipicolinate synthase; Region: dapA; TIGR00674
749222002653	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
749222002654	dimer interface [polypeptide binding]; other site
749222002655	active site
749222002656	catalytic residue [active]
749222002657	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
749222002658	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
749222002659	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
749222002660	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198
749222002661	Predicted transcriptional regulator [Transcription]; Region: COG2378
749222002662	HTH domain; Region: HTH_11; cl17392
749222002663	WYL domain; Region: WYL; pfam13280
749222002664	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
749222002665	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
749222002666	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
749222002667	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
749222002668	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
749222002669	dimer interface [polypeptide binding]; other site
749222002670	active site
749222002671	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
749222002672	catalytic residues [active]
749222002673	substrate binding site [chemical binding]; other site
749222002674	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
749222002675	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
749222002676	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
749222002677	catalytic residues [active]
749222002678	Response regulator receiver domain; Region: Response_reg; pfam00072
749222002679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222002680	active site
749222002681	phosphorylation site [posttranslational modification]
749222002682	intermolecular recognition site; other site
749222002683	dimerization interface [polypeptide binding]; other site
749222002684	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
749222002685	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222002686	Walker A/P-loop; other site
749222002687	ATP binding site [chemical binding]; other site
749222002688	ABC transporter signature motif; other site
749222002689	Walker B; other site
749222002690	D-loop; other site
749222002691	H-loop/switch region; other site
749222002692	ABC transporter; Region: ABC_tran_2; pfam12848
749222002693	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
749222002694	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
749222002695	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
749222002696	minor groove reading motif; other site
749222002697	helix-hairpin-helix signature motif; other site
749222002698	active site
749222002699	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
749222002700	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
749222002701	DNA polymerase IV; Validated; Region: PRK01810
749222002702	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
749222002703	active site
749222002704	DNA binding site [nucleotide binding]
749222002705	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
749222002706	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
749222002707	active site
749222002708	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
749222002709	N-acetyl-D-glucosamine binding site [chemical binding]; other site
749222002710	catalytic residue [active]
749222002711	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
749222002712	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
749222002713	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
749222002714	Sporulation related domain; Region: SPOR; pfam05036
749222002715	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
749222002716	putative active site pocket [active]
749222002717	4-fold oligomerization interface [polypeptide binding]; other site
749222002718	metal binding residues [ion binding]; metal-binding site
749222002719	3-fold/trimer interface [polypeptide binding]; other site
749222002720	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
749222002721	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222002722	active site
749222002723	motif I; other site
749222002724	motif II; other site
749222002725	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
749222002726	OstA-like protein; Region: OstA; pfam03968
749222002727	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
749222002728	G1 box; other site
749222002729	GTP/Mg2+ binding site [chemical binding]; other site
749222002730	Switch I region; other site
749222002731	G2 box; other site
749222002732	G3 box; other site
749222002733	Switch II region; other site
749222002734	G4 box; other site
749222002735	G5 box; other site
749222002736	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
749222002737	Coenzyme A binding pocket [chemical binding]; other site
749222002738	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
749222002739	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
749222002740	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
749222002741	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
749222002742	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
749222002743	dimer interface [polypeptide binding]; other site
749222002744	motif 1; other site
749222002745	active site
749222002746	motif 2; other site
749222002747	motif 3; other site
749222002748	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
749222002749	anticodon binding site; other site
749222002750	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
749222002751	thymidylate kinase; Validated; Region: tmk; PRK00698
749222002752	TMP-binding site; other site
749222002753	ATP-binding site [chemical binding]; other site
749222002754	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
749222002755	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
749222002756	active site
749222002757	(T/H)XGH motif; other site
749222002758	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
749222002759	Flavoprotein; Region: Flavoprotein; pfam02441
749222002760	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
749222002761	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
749222002762	ligand binding site [chemical binding]; other site
749222002763	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
749222002764	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
749222002765	hypothetical protein; Provisional; Region: PRK08609
749222002766	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
749222002767	active site
749222002768	primer binding site [nucleotide binding]; other site
749222002769	NTP  binding site [chemical binding]; other site
749222002770	metal binding triad [ion binding]; metal-binding site
749222002771	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
749222002772	active site
749222002773	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222002774	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
749222002775	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
749222002776	Beta-Casp domain; Region: Beta-Casp; smart01027
749222002777	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
749222002778	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
749222002779	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
749222002780	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
749222002781	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
749222002782	Soluble P-type ATPase [General function prediction only]; Region: COG4087
749222002783	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
749222002784	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
749222002785	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
749222002786	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
749222002787	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
749222002788	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
749222002789	Soluble P-type ATPase [General function prediction only]; Region: COG4087
749222002790	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
749222002791	Predicted membrane protein [Function unknown]; Region: COG3174
749222002792	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
749222002793	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
749222002794	YfdX protein; Region: YfdX; pfam10938
749222002795	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
749222002796	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
749222002797	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
749222002798	dinuclear metal binding motif [ion binding]; other site
749222002799	phosphoenolpyruvate synthase; Validated; Region: PRK06464
749222002800	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
749222002801	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
749222002802	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
749222002803	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
749222002804	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
749222002805	putative active site; other site
749222002806	catalytic residue [active]
749222002807	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
749222002808	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
749222002809	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
749222002810	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
749222002811	enolase; Provisional; Region: eno; PRK00077
749222002812	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
749222002813	dimer interface [polypeptide binding]; other site
749222002814	metal binding site [ion binding]; metal-binding site
749222002815	substrate binding pocket [chemical binding]; other site
749222002816	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
749222002817	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
749222002818	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
749222002819	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
749222002820	Cl- selectivity filter; other site
749222002821	Cl- binding residues [ion binding]; other site
749222002822	pore gating glutamate residue; other site
749222002823	dimer interface [polypeptide binding]; other site
749222002824	MarC family integral membrane protein; Region: MarC; cl00919
749222002825	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
749222002826	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
749222002827	cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14535
749222002828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222002829	AAA domain; Region: AAA_21; pfam13304
749222002830	Walker A/P-loop; other site
749222002831	ATP binding site [chemical binding]; other site
749222002832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222002833	Walker B; other site
749222002834	D-loop; other site
749222002835	H-loop/switch region; other site
749222002836	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
749222002837	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
749222002838	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
749222002839	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
749222002840	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
749222002841	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
749222002842	glycogen branching enzyme; Provisional; Region: PRK12313
749222002843	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
749222002844	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
749222002845	active site
749222002846	catalytic site [active]
749222002847	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
749222002848	glycogen synthase; Provisional; Region: glgA; PRK00654
749222002849	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
749222002850	ADP-binding pocket [chemical binding]; other site
749222002851	homodimer interface [polypeptide binding]; other site
749222002852	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
749222002853	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
749222002854	nucleotide binding site [chemical binding]; other site
749222002855	ADP-glucose phosphorylase; Region: PLN02643
749222002856	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
749222002857	nucleotide binding site/active site [active]
749222002858	HIT family signature motif; other site
749222002859	catalytic residue [active]
749222002860	N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793
749222002861	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
749222002862	active site
749222002863	catalytic site [active]
749222002864	homodimer interface [polypeptide binding]; other site
749222002865	Lid 1; other site
749222002866	Domain of unknown function (DUF1925); Region: DUF1925; pfam09094
749222002867	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
749222002868	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
749222002869	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
749222002870	putative active site [active]
749222002871	catalytic site [active]
749222002872	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
749222002873	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
749222002874	active site
749222002875	Substrate binding site; other site
749222002876	Mg++ binding site; other site
749222002877	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
749222002878	putative trimer interface [polypeptide binding]; other site
749222002879	putative CoA binding site [chemical binding]; other site
749222002880	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
749222002881	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
749222002882	active site
749222002883	substrate binding site [chemical binding]; other site
749222002884	metal binding site [ion binding]; metal-binding site
749222002885	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
749222002886	glycogen binding site [chemical binding]; other site
749222002887	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
749222002888	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
749222002889	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
749222002890	catalytic core [active]
749222002891	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
749222002892	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
749222002893	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
749222002894	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
749222002895	tetramer interface [polypeptide binding]; other site
749222002896	TPP-binding site [chemical binding]; other site
749222002897	heterodimer interface [polypeptide binding]; other site
749222002898	phosphorylation loop region [posttranslational modification]
749222002899	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
749222002900	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
749222002901	alpha subunit interface [polypeptide binding]; other site
749222002902	TPP binding site [chemical binding]; other site
749222002903	heterodimer interface [polypeptide binding]; other site
749222002904	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
749222002905	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
749222002906	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
749222002907	E3 interaction surface; other site
749222002908	lipoyl attachment site [posttranslational modification]; other site
749222002909	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
749222002910	myosin-cross-reactive antigen; Provisional; Region: PRK13977
749222002911	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
749222002912	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
749222002913	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
749222002914	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
749222002915	active site
749222002916	NTP binding site [chemical binding]; other site
749222002917	metal binding triad [ion binding]; metal-binding site
749222002918	antibiotic binding site [chemical binding]; other site
749222002919	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
749222002920	lipoyl synthase; Provisional; Region: PRK05481
749222002921	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222002922	FeS/SAM binding site; other site
749222002923	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
749222002924	phosphoglucomutase; Validated; Region: PRK07564
749222002925	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
749222002926	active site
749222002927	substrate binding site [chemical binding]; other site
749222002928	metal binding site [ion binding]; metal-binding site
749222002929	glucose-6-phosphate isomerase; Provisional; Region: PRK03868
749222002930	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
749222002931	dimer interface [polypeptide binding]; other site
749222002932	active site
749222002933	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
749222002934	dimer interface [polypeptide binding]; other site
749222002935	active site
749222002936	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
749222002937	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
749222002938	6-phosphofructokinase; Provisional; Region: PRK03202
749222002939	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
749222002940	active site
749222002941	ADP/pyrophosphate binding site [chemical binding]; other site
749222002942	dimerization interface [polypeptide binding]; other site
749222002943	allosteric effector site; other site
749222002944	fructose-1,6-bisphosphate binding site; other site
749222002945	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
749222002946	substrate binding site [chemical binding]; other site
749222002947	active site
749222002948	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
749222002949	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
749222002950	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
749222002951	DNA gyrase subunit A; Validated; Region: PRK05560
749222002952	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
749222002953	CAP-like domain; other site
749222002954	active site
749222002955	primary dimer interface [polypeptide binding]; other site
749222002956	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
749222002957	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
749222002958	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
749222002959	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
749222002960	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
749222002961	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
749222002962	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
749222002963	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
749222002964	putative ATP binding site [chemical binding]; other site
749222002965	putative substrate interface [chemical binding]; other site
749222002966	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
749222002967	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
749222002968	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
749222002969	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
749222002970	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
749222002971	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
749222002972	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
749222002973	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
749222002974	putative active site [active]
749222002975	putative metal binding site [ion binding]; other site
749222002976	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
749222002977	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
749222002978	Nitrogen regulatory protein P-II; Region: P-II; smart00938
749222002979	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
749222002980	Protein of unknown function DUF89; Region: DUF89; cl15397
749222002981	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
749222002982	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
749222002983	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
749222002984	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
749222002985	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
749222002986	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
749222002987	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
749222002988	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
749222002989	dimer interface [polypeptide binding]; other site
749222002990	decamer (pentamer of dimers) interface [polypeptide binding]; other site
749222002991	catalytic triad [active]
749222002992	peroxidatic and resolving cysteines [active]
749222002993	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
749222002994	metal binding site 2 [ion binding]; metal-binding site
749222002995	putative DNA binding helix; other site
749222002996	metal binding site 1 [ion binding]; metal-binding site
749222002997	dimer interface [polypeptide binding]; other site
749222002998	structural Zn2+ binding site [ion binding]; other site
749222002999	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
749222003000	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
749222003001	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
749222003002	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
749222003003	DNA-binding site [nucleotide binding]; DNA binding site
749222003004	RNA-binding motif; other site
749222003005	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
749222003006	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
749222003007	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
749222003008	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
749222003009	ligand binding site [chemical binding]; other site
749222003010	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
749222003011	catalytic residues [active]
749222003012	arginine decarboxylase; Provisional; Region: PRK05354
749222003013	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
749222003014	active site
749222003015	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
749222003016	catalytic residues [active]
749222003017	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
749222003018	serine O-acetyltransferase; Region: cysE; TIGR01172
749222003019	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
749222003020	trimer interface [polypeptide binding]; other site
749222003021	active site
749222003022	substrate binding site [chemical binding]; other site
749222003023	CoA binding site [chemical binding]; other site
749222003024	Sugar fermentation stimulation protein; Region: SfsA; cl00647
749222003025	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
749222003026	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
749222003027	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
749222003028	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
749222003029	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
749222003030	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
749222003031	active site
749222003032	NTP binding site [chemical binding]; other site
749222003033	metal binding triad [ion binding]; metal-binding site
749222003034	antibiotic binding site [chemical binding]; other site
749222003035	Protein of unknown function DUF86; Region: DUF86; cl01031
749222003036	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
749222003037	Family of unknown function (DUF694); Region: DUF694; pfam05107
749222003038	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
749222003039	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
749222003040	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
749222003041	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
749222003042	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
749222003043	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
749222003044	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
749222003045	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
749222003046	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
749222003047	von Willebrand factor type A domain; Region: VWA_2; pfam13519
749222003048	metal ion-dependent adhesion site (MIDAS); other site
749222003049	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222003050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222003051	active site
749222003052	phosphorylation site [posttranslational modification]
749222003053	intermolecular recognition site; other site
749222003054	dimerization interface [polypeptide binding]; other site
749222003055	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
749222003056	DNA binding site [nucleotide binding]
749222003057	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; pfam01184
749222003058	acetyl-CoA synthetase; Provisional; Region: PRK00174
749222003059	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
749222003060	active site
749222003061	CoA binding site [chemical binding]; other site
749222003062	acyl-activating enzyme (AAE) consensus motif; other site
749222003063	AMP binding site [chemical binding]; other site
749222003064	acetate binding site [chemical binding]; other site
749222003065	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
749222003066	metal binding site [ion binding]; metal-binding site
749222003067	active site
749222003068	I-site; other site
749222003069	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
749222003070	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222003071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222003072	active site
749222003073	phosphorylation site [posttranslational modification]
749222003074	intermolecular recognition site; other site
749222003075	dimerization interface [polypeptide binding]; other site
749222003076	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222003077	DNA binding site [nucleotide binding]
749222003078	NMT1/THI5 like; Region: NMT1; pfam09084
749222003079	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
749222003080	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
749222003081	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
749222003082	substrate binding pocket [chemical binding]; other site
749222003083	membrane-bound complex binding site; other site
749222003084	hinge residues; other site
749222003085	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
749222003086	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
749222003087	substrate binding pocket [chemical binding]; other site
749222003088	membrane-bound complex binding site; other site
749222003089	hinge residues; other site
749222003090	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222003091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222003092	ATP binding site [chemical binding]; other site
749222003093	Mg2+ binding site [ion binding]; other site
749222003094	G-X-G motif; other site
749222003095	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
749222003096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222003097	active site
749222003098	phosphorylation site [posttranslational modification]
749222003099	intermolecular recognition site; other site
749222003100	dimerization interface [polypeptide binding]; other site
749222003101	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
749222003102	Cysteine-rich domain; Region: CCG; pfam02754
749222003103	Cysteine-rich domain; Region: CCG; pfam02754
749222003104	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
749222003105	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
749222003106	catalytic loop [active]
749222003107	iron binding site [ion binding]; other site
749222003108	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
749222003109	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
749222003110	L-aspartate oxidase; Provisional; Region: PRK06175
749222003111	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
749222003112	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
749222003113	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
749222003114	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
749222003115	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
749222003116	dimerization interface [polypeptide binding]; other site
749222003117	thiamine monophosphate kinase; Provisional; Region: PRK05731
749222003118	ATP binding site [chemical binding]; other site
749222003119	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
749222003120	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
749222003121	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222003122	catalytic residue [active]
749222003123	DEAD-like helicases superfamily; Region: DEXDc; smart00487
749222003124	DEAD/DEAH box helicase; Region: DEAD; pfam00270
749222003125	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
749222003126	nucleotide binding region [chemical binding]; other site
749222003127	ATP-binding site [chemical binding]; other site
749222003128	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
749222003129	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
749222003130	Putative catalytic NodB homology domain of uncharacterized Mll8295 protein encoded from Rhizobium loti and its bacterial homologs; Region: CE4_Mll8295_like; cd10946
749222003131	NodB motif; other site
749222003132	putative active site [active]
749222003133	putative catalytic site [active]
749222003134	putative Zn binding site [ion binding]; other site
749222003135	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
749222003136	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
749222003137	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
749222003138	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
749222003139	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
749222003140	Part of AAA domain; Region: AAA_19; pfam13245
749222003141	Family description; Region: UvrD_C_2; pfam13538
749222003142	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
749222003143	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
749222003144	hinge; other site
749222003145	active site
749222003146	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
749222003147	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
749222003148	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
749222003149	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
749222003150	Walker A motif; other site
749222003151	fructose-1,6-bisphosphatase; Provisional; Region: PRK09293
749222003152	active site
749222003153	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
749222003154	active site
749222003155	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
749222003156	active site
749222003157	Transposase IS200 like; Region: Y1_Tnp; pfam01797
749222003158	Uncharacterized conserved protein [Function unknown]; Region: COG1739
749222003159	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
749222003160	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
749222003161	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
749222003162	THF binding site; other site
749222003163	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
749222003164	substrate binding site [chemical binding]; other site
749222003165	THF binding site; other site
749222003166	zinc-binding site [ion binding]; other site
749222003167	VanZ like family; Region: VanZ; cl01971
749222003168	ferrochelatase; Reviewed; Region: hemH; PRK00035
749222003169	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
749222003170	C-terminal domain interface [polypeptide binding]; other site
749222003171	active site
749222003172	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
749222003173	active site
749222003174	N-terminal domain interface [polypeptide binding]; other site
749222003175	ribonuclease Z; Region: RNase_Z; TIGR02651
749222003176	Family of unknown function (DUF490); Region: DUF490; pfam04357
749222003177	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
749222003178	Surface antigen; Region: Bac_surface_Ag; pfam01103
749222003179	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
749222003180	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
749222003181	Walker A/P-loop; other site
749222003182	ATP binding site [chemical binding]; other site
749222003183	Q-loop/lid; other site
749222003184	ABC transporter signature motif; other site
749222003185	Walker B; other site
749222003186	D-loop; other site
749222003187	H-loop/switch region; other site
749222003188	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
749222003189	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
749222003190	putative catalytic cysteine [active]
749222003191	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
749222003192	catalytic core [active]
749222003193	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
749222003194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
749222003195	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
749222003196	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14183
749222003197	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
749222003198	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
749222003199	homodimer interface [polypeptide binding]; other site
749222003200	NADP binding site [chemical binding]; other site
749222003201	substrate binding site [chemical binding]; other site
749222003202	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
749222003203	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
749222003204	Catalytic site [active]
749222003205	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
749222003206	Catalytic site [active]
749222003207	Peptidase family M50; Region: Peptidase_M50; pfam02163
749222003208	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
749222003209	active site
749222003210	putative substrate binding region [chemical binding]; other site
749222003211	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
749222003212	Cupin domain; Region: Cupin_2; pfam07883
749222003213	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
749222003214	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
749222003215	active site
749222003216	HIGH motif; other site
749222003217	nucleotide binding site [chemical binding]; other site
749222003218	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
749222003219	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
749222003220	active site
749222003221	KMSKS motif; other site
749222003222	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
749222003223	tRNA binding surface [nucleotide binding]; other site
749222003224	anticodon binding site; other site
749222003225	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
749222003226	Methyltransferase domain; Region: Methyltransf_11; pfam08241
749222003227	S-adenosylmethionine binding site [chemical binding]; other site
749222003228	hypothetical protein; Provisional; Region: PRK09256
749222003229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222003230	Methyltransferase domain; Region: Methyltransf_23; pfam13489
749222003231	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
749222003232	G1 box; other site
749222003233	GTP/Mg2+ binding site [chemical binding]; other site
749222003234	G2 box; other site
749222003235	Switch I region; other site
749222003236	G3 box; other site
749222003237	Switch II region; other site
749222003238	G4 box; other site
749222003239	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
749222003240	YfdX protein; Region: YfdX; pfam10938
749222003241	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
749222003242	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
749222003243	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
749222003244	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
749222003245	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415
749222003246	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
749222003247	NAD binding site [chemical binding]; other site
749222003248	homotetramer interface [polypeptide binding]; other site
749222003249	homodimer interface [polypeptide binding]; other site
749222003250	substrate binding site [chemical binding]; other site
749222003251	active site
749222003252	Soluble P-type ATPase [General function prediction only]; Region: COG4087
749222003253	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
749222003254	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222003255	Walker A/P-loop; other site
749222003256	ATP binding site [chemical binding]; other site
749222003257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222003258	ABC transporter signature motif; other site
749222003259	Walker B; other site
749222003260	D-loop; other site
749222003261	H-loop/switch region; other site
749222003262	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
749222003263	ATP-NAD kinase; Region: NAD_kinase; pfam01513
749222003264	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
749222003265	putative catalytic site [active]
749222003266	putative metal binding site [ion binding]; other site
749222003267	putative phosphate binding site [ion binding]; other site
749222003268	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222003269	S-adenosylmethionine binding site [chemical binding]; other site
749222003270	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
749222003271	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
749222003272	argininosuccinate synthase; Provisional; Region: PRK13820
749222003273	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
749222003274	ANP binding site [chemical binding]; other site
749222003275	Substrate Binding Site II [chemical binding]; other site
749222003276	Substrate Binding Site I [chemical binding]; other site
749222003277	pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265
749222003278	active site
749222003279	hydrophilic channel; other site
749222003280	dimerization interface [polypeptide binding]; other site
749222003281	catalytic residues [active]
749222003282	active site lid [active]
749222003283	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946
749222003284	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
749222003285	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
749222003286	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
749222003287	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
749222003288	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
749222003289	DEAD/DEAH box helicase; Region: DEAD; pfam00270
749222003290	ATP binding site [chemical binding]; other site
749222003291	putative Mg++ binding site [ion binding]; other site
749222003292	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
749222003293	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
749222003294	nucleotide binding region [chemical binding]; other site
749222003295	ATP-binding site [chemical binding]; other site
749222003296	SEC-C motif; Region: SEC-C; pfam02810
749222003297	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
749222003298	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
749222003299	FtsX-like permease family; Region: FtsX; pfam02687
749222003300	Protein of unknown function; Region: DUF3971; pfam13116
749222003301	AsmA-like C-terminal region; Region: AsmA_1; pfam13109
749222003302	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
749222003303	dimerization interface [polypeptide binding]; other site
749222003304	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
749222003305	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
749222003306	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
749222003307	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
749222003308	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
749222003309	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222003310	FeS/SAM binding site; other site
749222003311	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
749222003312	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
749222003313	Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236
749222003314	Terminase-like family; Region: Terminase_6; pfam03237
749222003315	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
749222003316	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
749222003317	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
749222003318	cofactor binding site; other site
749222003319	DNA binding site [nucleotide binding]
749222003320	substrate interaction site [chemical binding]; other site
749222003321	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
749222003322	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
749222003323	non-specific DNA binding site [nucleotide binding]; other site
749222003324	salt bridge; other site
749222003325	sequence-specific DNA binding site [nucleotide binding]; other site
749222003326	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
749222003327	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
749222003328	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
749222003329	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
749222003330	dimer interface [polypeptide binding]; other site
749222003331	ssDNA binding site [nucleotide binding]; other site
749222003332	tetramer (dimer of dimers) interface [polypeptide binding]; other site
749222003333	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
749222003334	active site
749222003335	metal binding site [ion binding]; metal-binding site
749222003336	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
749222003337	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
749222003338	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
749222003339	Walker A motif; other site
749222003340	ATP binding site [chemical binding]; other site
749222003341	Walker B motif; other site
749222003342	replicative DNA helicase; Provisional; Region: PRK08506
749222003343	Helix-turn-helix domain; Region: HTH_36; pfam13730
749222003344	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
749222003345	non-specific DNA binding site [nucleotide binding]; other site
749222003346	sequence-specific DNA binding site [nucleotide binding]; other site
749222003347	salt bridge; other site
749222003348	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
749222003349	Predicted transcriptional regulator [Transcription]; Region: COG2932
749222003350	non-specific DNA binding site [nucleotide binding]; other site
749222003351	salt bridge; other site
749222003352	sequence-specific DNA binding site [nucleotide binding]; other site
749222003353	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
749222003354	Catalytic site [active]
749222003355	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
749222003356	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
749222003357	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
749222003358	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
749222003359	active site
749222003360	DNA binding site [nucleotide binding]
749222003361	Int/Topo IB signature motif; other site
749222003362	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
749222003363	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
749222003364	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
749222003365	anti sigma factor interaction site; other site
749222003366	regulatory phosphorylation site [posttranslational modification]; other site
749222003367	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
749222003368	Permease; Region: Permease; pfam02405
749222003369	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
749222003370	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
749222003371	Walker A/P-loop; other site
749222003372	ATP binding site [chemical binding]; other site
749222003373	Q-loop/lid; other site
749222003374	ABC transporter signature motif; other site
749222003375	Walker B; other site
749222003376	D-loop; other site
749222003377	H-loop/switch region; other site
749222003378	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
749222003379	mce related protein; Region: MCE; pfam02470
749222003380	Protein of unknown function (DUF330); Region: DUF330; cl01135
749222003381	FUN14 family; Region: FUN14; cl01015
749222003382	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
749222003383	Ligand Binding Site [chemical binding]; other site
749222003384	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
749222003385	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
749222003386	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
749222003387	active site
749222003388	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
749222003389	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
749222003390	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222003391	Walker A motif; other site
749222003392	ATP binding site [chemical binding]; other site
749222003393	Walker B motif; other site
749222003394	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
749222003395	rod shape-determining protein MreB; Provisional; Region: PRK13927
749222003396	MreB and similar proteins; Region: MreB_like; cd10225
749222003397	nucleotide binding site [chemical binding]; other site
749222003398	Mg binding site [ion binding]; other site
749222003399	putative protofilament interaction site [polypeptide binding]; other site
749222003400	RodZ interaction site [polypeptide binding]; other site
749222003401	rod shape-determining protein MreC; Provisional; Region: PRK13922
749222003402	rod shape-determining protein MreC; Region: MreC; pfam04085
749222003403	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
749222003404	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
749222003405	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
749222003406	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
749222003407	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
749222003408	ATP-grasp domain; Region: ATP-grasp_4; cl17255
749222003409	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
749222003410	IMP binding site; other site
749222003411	dimer interface [polypeptide binding]; other site
749222003412	partial ornithine binding site; other site
749222003413	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
749222003414	hypothetical protein; Provisional; Region: PRK12378
749222003415	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
749222003416	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
749222003417	active site
749222003418	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
749222003419	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
749222003420	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
749222003421	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
749222003422	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
749222003423	active site
749222003424	Zn binding site [ion binding]; other site
749222003425	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
749222003426	Predicted integral membrane protein [Function unknown]; Region: COG5615
749222003427	GTP-binding protein LepA; Provisional; Region: PRK05433
749222003428	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
749222003429	G1 box; other site
749222003430	putative GEF interaction site [polypeptide binding]; other site
749222003431	GTP/Mg2+ binding site [chemical binding]; other site
749222003432	Switch I region; other site
749222003433	G2 box; other site
749222003434	G3 box; other site
749222003435	Switch II region; other site
749222003436	G4 box; other site
749222003437	G5 box; other site
749222003438	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
749222003439	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
749222003440	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
749222003441	PAS fold; Region: PAS_4; pfam08448
749222003442	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
749222003443	putative active site [active]
749222003444	heme pocket [chemical binding]; other site
749222003445	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
749222003446	PAS domain; Region: PAS_9; pfam13426
749222003447	putative active site [active]
749222003448	heme pocket [chemical binding]; other site
749222003449	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
749222003450	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
749222003451	metal binding site [ion binding]; metal-binding site
749222003452	active site
749222003453	I-site; other site
749222003454	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
749222003455	FIST N domain; Region: FIST; pfam08495
749222003456	Uncharacterized conserved protein [Function unknown]; Region: COG3287
749222003457	FIST C domain; Region: FIST_C; pfam10442
749222003458	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
749222003459	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
749222003460	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
749222003461	active site
749222003462	PAS domain; Region: PAS_9; pfam13426
749222003463	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
749222003464	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
749222003465	metal binding site [ion binding]; metal-binding site
749222003466	active site
749222003467	I-site; other site
749222003468	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
749222003469	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
749222003470	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
749222003471	oligomer interface [polypeptide binding]; other site
749222003472	metal binding site [ion binding]; metal-binding site
749222003473	metal binding site [ion binding]; metal-binding site
749222003474	putative Cl binding site [ion binding]; other site
749222003475	aspartate ring; other site
749222003476	basic sphincter; other site
749222003477	hydrophobic gate; other site
749222003478	periplasmic entrance; other site
749222003479	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
749222003480	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
749222003481	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
749222003482	ATP binding site [chemical binding]; other site
749222003483	putative Mg++ binding site [ion binding]; other site
749222003484	nucleotide binding region [chemical binding]; other site
749222003485	helicase superfamily c-terminal domain; Region: HELICc; smart00490
749222003486	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
749222003487	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
749222003488	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
749222003489	Uncharacterized conserved protein [Function unknown]; Region: COG2454
749222003490	Methyltransferase domain; Region: Methyltransf_23; pfam13489
749222003491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222003492	S-adenosylmethionine binding site [chemical binding]; other site
749222003493	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
749222003494	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
749222003495	putative metal binding site [ion binding]; other site
749222003496	Uncharacterized conserved protein [Function unknown]; Region: COG1432
749222003497	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
749222003498	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
749222003499	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
749222003500	active site
749222003501	HIGH motif; other site
749222003502	nucleotide binding site [chemical binding]; other site
749222003503	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
749222003504	KMSKS motif; other site
749222003505	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
749222003506	tRNA binding surface [nucleotide binding]; other site
749222003507	anticodon binding site; other site
749222003508	methionine sulfoxide reductase A; Provisional; Region: PRK14054
749222003509	Acylphosphatase; Region: Acylphosphatase; pfam00708
749222003510	PemK-like protein; Region: PemK; pfam02452
749222003511	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
749222003512	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
749222003513	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
749222003514	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
749222003515	active site
749222003516	substrate-binding site [chemical binding]; other site
749222003517	metal-binding site [ion binding]
749222003518	ATP binding site [chemical binding]; other site
749222003519	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
749222003520	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
749222003521	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
749222003522	active site
749222003523	catalytic residues [active]
749222003524	metal binding site [ion binding]; metal-binding site
749222003525	homodimer binding site [polypeptide binding]; other site
749222003526	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
749222003527	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
749222003528	carboxyltransferase (CT) interaction site; other site
749222003529	biotinylation site [posttranslational modification]; other site
749222003530	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458
749222003531	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
749222003532	DEAD-like helicases superfamily; Region: DEXDc; smart00487
749222003533	ATP binding site [chemical binding]; other site
749222003534	Mg++ binding site [ion binding]; other site
749222003535	motif III; other site
749222003536	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
749222003537	nucleotide binding region [chemical binding]; other site
749222003538	ATP-binding site [chemical binding]; other site
749222003539	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
749222003540	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
749222003541	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
749222003542	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222003543	Walker A/P-loop; other site
749222003544	ATP binding site [chemical binding]; other site
749222003545	Q-loop/lid; other site
749222003546	ABC transporter signature motif; other site
749222003547	Walker B; other site
749222003548	D-loop; other site
749222003549	H-loop/switch region; other site
749222003550	phosphoserine phosphatase SerB; Region: serB; TIGR00338
749222003551	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
749222003552	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222003553	motif II; other site
749222003554	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
749222003555	FAD binding site [chemical binding]; other site
749222003556	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
749222003557	Malic enzyme, N-terminal domain; Region: malic; pfam00390
749222003558	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
749222003559	putative NAD(P) binding site [chemical binding]; other site
749222003560	hydroxyglutarate oxidase; Provisional; Region: PRK11728
749222003561	Predicted dehydrogenase [General function prediction only]; Region: COG0579
749222003562	Transposase IS200 like; Region: Y1_Tnp; pfam01797
749222003563	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
749222003564	Citrate synthase; Region: Citrate_synt; pfam00285
749222003565	oxalacetate binding site [chemical binding]; other site
749222003566	citrylCoA binding site [chemical binding]; other site
749222003567	coenzyme A binding site [chemical binding]; other site
749222003568	catalytic triad [active]
749222003569	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
749222003570	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
749222003571	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
749222003572	Sulfate transporter family; Region: Sulfate_transp; pfam00916
749222003573	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
749222003574	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
749222003575	active site
749222003576	NTP binding site [chemical binding]; other site
749222003577	metal binding triad [ion binding]; metal-binding site
749222003578	antibiotic binding site [chemical binding]; other site
749222003579	Uncharacterized conserved protein [Function unknown]; Region: COG2445
749222003580	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
749222003581	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
749222003582	active site
749222003583	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
749222003584	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
749222003585	active site
749222003586	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
749222003587	PAS fold; Region: PAS_3; pfam08447
749222003588	putative active site [active]
749222003589	heme pocket [chemical binding]; other site
749222003590	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
749222003591	Domain of unknown function (DUF389); Region: DUF389; pfam04087
749222003592	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
749222003593	MPT binding site; other site
749222003594	trimer interface [polypeptide binding]; other site
749222003595	short chain dehydrogenase; Provisional; Region: PRK05993
749222003596	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
749222003597	NADP binding site [chemical binding]; other site
749222003598	active site
749222003599	steroid binding site; other site
749222003600	Transposase IS200 like; Region: Y1_Tnp; pfam01797
749222003601	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
749222003602	putative DNA binding helix; other site
749222003603	Integrase core domain; Region: rve; pfam00665
749222003604	homoserine O-acetyltransferase; Provisional; Region: PRK08775
749222003605	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
749222003606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222003607	Walker A motif; other site
749222003608	ATP binding site [chemical binding]; other site
749222003609	Walker B motif; other site
749222003610	arginine finger; other site
749222003611	Peptidase family M41; Region: Peptidase_M41; pfam01434
749222003612	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
749222003613	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
749222003614	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222003615	FeS/SAM binding site; other site
749222003616	Mechanosensitive ion channel; Region: MS_channel; pfam00924
749222003617	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
749222003618	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
749222003619	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
749222003620	active site
749222003621	dimer interface [polypeptide binding]; other site
749222003622	metal binding site [ion binding]; metal-binding site
749222003623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400
749222003624	TrkA-C domain; Region: TrkA_C; pfam02080
749222003625	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
749222003626	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
749222003627	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
749222003628	pseudouridine synthase; Region: TIGR00093
749222003629	active site
749222003630	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
749222003631	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
749222003632	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
749222003633	ATP binding site [chemical binding]; other site
749222003634	putative Mg++ binding site [ion binding]; other site
749222003635	MULE transposase domain; Region: MULE; pfam10551
749222003636	Abi-like protein; Region: Abi_2; cl01988
749222003637	HsdM N-terminal domain; Region: HsdM_N; pfam12161
749222003638	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
749222003639	Methyltransferase domain; Region: Methyltransf_26; pfam13659
749222003640	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
749222003641	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
749222003642	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
749222003643	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
749222003644	GTP/Mg2+ binding site [chemical binding]; other site
749222003645	G4 box; other site
749222003646	G5 box; other site
749222003647	trmE is a tRNA modification GTPase; Region: trmE; cd04164
749222003648	G1 box; other site
749222003649	G1 box; other site
749222003650	GTP/Mg2+ binding site [chemical binding]; other site
749222003651	Switch I region; other site
749222003652	Switch I region; other site
749222003653	G2 box; other site
749222003654	G2 box; other site
749222003655	Switch II region; other site
749222003656	G3 box; other site
749222003657	G3 box; other site
749222003658	Switch II region; other site
749222003659	G4 box; other site
749222003660	G5 box; other site
749222003661	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
749222003662	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
749222003663	G-X-X-G motif; other site
749222003664	membrane protein insertase; Provisional; Region: PRK01318
749222003665	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
749222003666	Ribonuclease P; Region: Ribonuclease_P; pfam00825
749222003667	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
749222003668	Uncharacterized conserved protein [Function unknown]; Region: COG1656
749222003669	Protein of unknown function DUF82; Region: DUF82; pfam01927
749222003670	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
749222003671	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
749222003672	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
749222003673	dimerization interface [polypeptide binding]; other site
749222003674	ATP binding site [chemical binding]; other site
749222003675	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
749222003676	dimerization interface [polypeptide binding]; other site
749222003677	ATP binding site [chemical binding]; other site
749222003678	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
749222003679	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
749222003680	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
749222003681	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
749222003682	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
749222003683	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
749222003684	L-aspartate oxidase; Provisional; Region: PRK06175
749222003685	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
749222003686	fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553
749222003687	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
749222003688	Iron-sulfur protein interface; other site
749222003689	proximal heme binding site [chemical binding]; other site
749222003690	distal heme binding site [chemical binding]; other site
749222003691	dimer interface [polypeptide binding]; other site
749222003692	glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410
749222003693	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
749222003694	active site
749222003695	HIGH motif; other site
749222003696	nucleotide binding site [chemical binding]; other site
749222003697	active site
749222003698	KMSKS motif; other site
749222003699	YGGT family; Region: YGGT; pfam02325
749222003700	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
749222003701	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
749222003702	N-acetyl-D-glucosamine binding site [chemical binding]; other site
749222003703	catalytic residue [active]
749222003704	hypothetical protein; Provisional; Region: PRK04233
749222003705	SEC-C motif; Region: SEC-C; pfam02810
749222003706	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
749222003707	Domain of unknown function DUF59; Region: DUF59; cl00941
749222003708	Fe-S metabolism associated domain; Region: SufE; cl00951
749222003709	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
749222003710	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
749222003711	FeS assembly ATPase SufC; Region: sufC; TIGR01978
749222003712	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
749222003713	Walker A/P-loop; other site
749222003714	ATP binding site [chemical binding]; other site
749222003715	Q-loop/lid; other site
749222003716	ABC transporter signature motif; other site
749222003717	Walker B; other site
749222003718	D-loop; other site
749222003719	H-loop/switch region; other site
749222003720	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
749222003721	putative ABC transporter; Region: ycf24; CHL00085
749222003722	Chorismate mutase type II; Region: CM_2; smart00830
749222003723	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
749222003724	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
749222003725	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
749222003726	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
749222003727	Methane oxygenase PmoA; Region: PmoA; pfam14100
749222003728	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
749222003729	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
749222003730	aspartate racemase; Region: asp_race; TIGR00035
749222003731	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
749222003732	classical (c) SDRs; Region: SDR_c; cd05233
749222003733	NAD(P) binding site [chemical binding]; other site
749222003734	active site
749222003735	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
749222003736	ATP-grasp domain; Region: ATP-grasp_4; cl17255
749222003737	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
749222003738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222003739	active site
749222003740	dimerization interface [polypeptide binding]; other site
749222003741	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222003742	DNA binding site [nucleotide binding]
749222003743	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
749222003744	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
749222003745	active site
749222003746	HIGH motif; other site
749222003747	KMSKS motif; other site
749222003748	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
749222003749	anticodon binding site; other site
749222003750	tRNA binding surface [nucleotide binding]; other site
749222003751	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
749222003752	dimer interface [polypeptide binding]; other site
749222003753	putative tRNA-binding site [nucleotide binding]; other site
749222003754	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
749222003755	dUTPase; Region: dUTPase_2; pfam08761
749222003756	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
749222003757	active site
749222003758	homodimer interface [polypeptide binding]; other site
749222003759	metal binding site [ion binding]; metal-binding site
749222003760	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
749222003761	active site
749222003762	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
749222003763	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
749222003764	Ligand Binding Site [chemical binding]; other site
749222003765	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
749222003766	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
749222003767	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
749222003768	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
749222003769	catalytic center binding site [active]
749222003770	ATP binding site [chemical binding]; other site
749222003771	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
749222003772	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
749222003773	active site
749222003774	Dehydroquinase class II; Region: DHquinase_II; pfam01220
749222003775	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
749222003776	trimer interface [polypeptide binding]; other site
749222003777	active site
749222003778	dimer interface [polypeptide binding]; other site
749222003779	chlorohydrolase; Provisional; Region: PRK08418
749222003780	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
749222003781	active site
749222003782	putative inner membrane protein; Provisional; Region: PRK11099
749222003783	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
749222003784	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
749222003785	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
749222003786	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
749222003787	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
749222003788	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
749222003789	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
749222003790	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
749222003791	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
749222003792	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222003793	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222003794	active site
749222003795	phosphorylation site [posttranslational modification]
749222003796	intermolecular recognition site; other site
749222003797	dimerization interface [polypeptide binding]; other site
749222003798	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222003799	DNA binding site [nucleotide binding]
749222003800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222003801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222003802	dimer interface [polypeptide binding]; other site
749222003803	phosphorylation site [posttranslational modification]
749222003804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222003805	ATP binding site [chemical binding]; other site
749222003806	Mg2+ binding site [ion binding]; other site
749222003807	G-X-G motif; other site
749222003808	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
749222003809	histidinol dehydrogenase; Region: hisD; TIGR00069
749222003810	NAD binding site [chemical binding]; other site
749222003811	dimerization interface [polypeptide binding]; other site
749222003812	product binding site; other site
749222003813	substrate binding site [chemical binding]; other site
749222003814	zinc binding site [ion binding]; other site
749222003815	catalytic residues [active]
749222003816	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
749222003817	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
749222003818	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
749222003819	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
749222003820	dimer interface [polypeptide binding]; other site
749222003821	putative radical transfer pathway; other site
749222003822	diiron center [ion binding]; other site
749222003823	tyrosyl radical; other site
749222003824	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
749222003825	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
749222003826	active site
749222003827	intersubunit interface [polypeptide binding]; other site
749222003828	zinc binding site [ion binding]; other site
749222003829	Na+ binding site [ion binding]; other site
749222003830	SurA N-terminal domain; Region: SurA_N_3; cl07813
749222003831	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
749222003832	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
749222003833	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
749222003834	minor groove reading motif; other site
749222003835	helix-hairpin-helix signature motif; other site
749222003836	substrate binding pocket [chemical binding]; other site
749222003837	active site
749222003838	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
749222003839	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
749222003840	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
749222003841	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
749222003842	active site residue [active]
749222003843	Transcriptional regulator [Transcription]; Region: LysR; COG0583
749222003844	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
749222003845	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
749222003846	putative dimerization interface [polypeptide binding]; other site
749222003847	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
749222003848	Part of AAA domain; Region: AAA_19; pfam13245
749222003849	AAA domain; Region: AAA_14; pfam13173
749222003850	Family description; Region: UvrD_C_2; pfam13538
749222003851	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099
749222003852	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
749222003853	RNA binding site [nucleotide binding]; other site
749222003854	active site
749222003855	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181
749222003856	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
749222003857	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
749222003858	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; pfam02086
749222003859	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
749222003860	SmpB-tmRNA interface; other site
749222003861	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
749222003862	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
749222003863	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593
749222003864	RimM N-terminal domain; Region: RimM; pfam01782
749222003865	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
749222003866	KH domain; Region: KH_4; pfam13083
749222003867	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
749222003868	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
749222003869	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
749222003870	DNA polymerase I; Provisional; Region: PRK05755
749222003871	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
749222003872	active site
749222003873	metal binding site 1 [ion binding]; metal-binding site
749222003874	putative 5' ssDNA interaction site; other site
749222003875	metal binding site 3; metal-binding site
749222003876	metal binding site 2 [ion binding]; metal-binding site
749222003877	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
749222003878	putative DNA binding site [nucleotide binding]; other site
749222003879	putative metal binding site [ion binding]; other site
749222003880	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
749222003881	active site
749222003882	catalytic site [active]
749222003883	substrate binding site [chemical binding]; other site
749222003884	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
749222003885	active site
749222003886	DNA binding site [nucleotide binding]
749222003887	catalytic site [active]
749222003888	Protein of unknown function DUF86; Region: DUF86; pfam01934
749222003889	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
749222003890	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
749222003891	PhnA protein; Region: PhnA; pfam03831
749222003892	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
749222003893	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
749222003894	putative active site [active]
749222003895	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
749222003896	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
749222003897	putative acyl-acceptor binding pocket; other site
749222003898	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
749222003899	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
749222003900	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
749222003901	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
749222003902	putative metal binding site; other site
749222003903	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
749222003904	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
749222003905	Substrate binding site; other site
749222003906	metal-binding site
749222003907	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
749222003908	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
749222003909	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
749222003910	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
749222003911	putative active site [active]
749222003912	AAA domain; Region: AAA_17; pfam13207
749222003913	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
749222003914	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
749222003915	putative ADP-binding pocket [chemical binding]; other site
749222003916	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
749222003917	O-Antigen ligase; Region: Wzy_C; pfam04932
749222003918	Transposase; Region: HTH_Tnp_1; pfam01527
749222003919	HTH-like domain; Region: HTH_21; pfam13276
749222003920	Integrase core domain; Region: rve; pfam00665
749222003921	Transposase IS200 like; Region: Y1_Tnp; pfam01797
749222003922	UDP-glucose 4-epimerase; Region: PLN02240
749222003923	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
749222003924	NAD binding site [chemical binding]; other site
749222003925	homodimer interface [polypeptide binding]; other site
749222003926	active site
749222003927	substrate binding site [chemical binding]; other site
749222003928	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
749222003929	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
749222003930	active site
749222003931	substrate binding site [chemical binding]; other site
749222003932	metal binding site [ion binding]; metal-binding site
749222003933	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
749222003934	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
749222003935	active site
749222003936	tetramer interface; other site
749222003937	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
749222003938	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
749222003939	substrate binding site; other site
749222003940	tetramer interface; other site
749222003941	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
749222003942	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
749222003943	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
749222003944	NADP binding site [chemical binding]; other site
749222003945	active site
749222003946	putative substrate binding site [chemical binding]; other site
749222003947	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
749222003948	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
749222003949	NAD binding site [chemical binding]; other site
749222003950	substrate binding site [chemical binding]; other site
749222003951	homodimer interface [polypeptide binding]; other site
749222003952	active site
749222003953	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
749222003954	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
749222003955	cytidylyltransferase; Region: cytidylyltransferase; cd02170
749222003956	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
749222003957	active site
749222003958	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
749222003959	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
749222003960	tetramer interface [polypeptide binding]; other site
749222003961	active site
749222003962	Mg2+/Mn2+ binding site [ion binding]; other site
749222003963	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
749222003964	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
749222003965	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
749222003966	TPP-binding site [chemical binding]; other site
749222003967	Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182
749222003968	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
749222003969	putative active site [active]
749222003970	metal binding site [ion binding]; metal-binding site
749222003971	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
749222003972	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
749222003973	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
749222003974	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
749222003975	active site
749222003976	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
749222003977	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
749222003978	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
749222003979	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
749222003980	putative ADP-binding pocket [chemical binding]; other site
749222003981	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
749222003982	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
749222003983	Substrate binding site; other site
749222003984	Cupin domain; Region: Cupin_2; cl17218
749222003985	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
749222003986	Bacterial sugar transferase; Region: Bac_transf; pfam02397
749222003987	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
749222003988	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
749222003989	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
749222003990	putative active site [active]
749222003991	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
749222003992	putative active site [active]
749222003993	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
749222003994	dimer interface [polypeptide binding]; other site
749222003995	active site
749222003996	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
749222003997	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
749222003998	putative ribose interaction site [chemical binding]; other site
749222003999	putative ADP binding site [chemical binding]; other site
749222004000	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
749222004001	active site
749222004002	HIGH motif; other site
749222004003	nucleotide binding site [chemical binding]; other site
749222004004	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
749222004005	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
749222004006	NAD(P) binding site [chemical binding]; other site
749222004007	active site
749222004008	histidinol-phosphatase; Region: hisB_Nterm; TIGR01261
749222004009	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222004010	active site
749222004011	motif I; other site
749222004012	motif II; other site
749222004013	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
749222004014	DGC domain; Region: DGC; cl01742
749222004015	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
749222004016	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
749222004017	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
749222004018	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
749222004019	DNA binding residues [nucleotide binding]
749222004020	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
749222004021	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
749222004022	putative MPT binding site; other site
749222004023	Protein of unknown function DUF45; Region: DUF45; pfam01863
749222004024	DNA helicase, putative; Region: TIGR00376
749222004025	AAA domain; Region: AAA_12; pfam13087
749222004026	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222004027	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
749222004028	hypothetical protein; Provisional; Region: PRK04081
749222004029	cell division protein FtsZ; Validated; Region: PRK09330
749222004030	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
749222004031	nucleotide binding site [chemical binding]; other site
749222004032	SulA interaction site; other site
749222004033	cell division protein FtsA; Region: ftsA; TIGR01174
749222004034	Cell division protein FtsA; Region: FtsA; smart00842
749222004035	Cell division protein FtsA; Region: FtsA; pfam14450
749222004036	SurA N-terminal domain; Region: SurA_N_3; pfam13624
749222004037	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
749222004038	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
749222004039	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
749222004040	inhibitor-cofactor binding pocket; inhibition site
749222004041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222004042	catalytic residue [active]
749222004043	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
749222004044	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
749222004045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222004046	S-adenosylmethionine binding site [chemical binding]; other site
749222004047	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
749222004048	Protein export membrane protein; Region: SecD_SecF; cl14618
749222004049	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
749222004050	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
749222004051	quinone interaction residues [chemical binding]; other site
749222004052	active site
749222004053	catalytic residues [active]
749222004054	FMN binding site [chemical binding]; other site
749222004055	substrate binding site [chemical binding]; other site
749222004056	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
749222004057	Protein of unknown function (DUF808); Region: DUF808; cl01002
749222004058	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
749222004059	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
749222004060	active site
749222004061	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
749222004062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
749222004063	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
749222004064	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
749222004065	active site
749222004066	dimer interface [polypeptide binding]; other site
749222004067	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
749222004068	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
749222004069	active site
749222004070	FMN binding site [chemical binding]; other site
749222004071	substrate binding site [chemical binding]; other site
749222004072	3Fe-4S cluster binding site [ion binding]; other site
749222004073	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
749222004074	domain interface; other site
749222004075	RecO N terminal; Region: RecO_N_2; cl15812
749222004076	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
749222004077	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
749222004078	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
749222004079	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
749222004080	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222004081	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222004082	flavoprotein, HI0933 family; Region: TIGR00275
749222004083	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
749222004084	Putative sensor; Region: Sensor; pfam13796
749222004085	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
749222004086	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
749222004087	active site
749222004088	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
749222004089	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
749222004090	putative substrate binding region [chemical binding]; other site
749222004091	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
749222004092	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
749222004093	catalytic residue [active]
749222004094	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
749222004095	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
749222004096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222004097	S-adenosylmethionine binding site [chemical binding]; other site
749222004098	Transglycosylase SLT domain; Region: SLT_2; pfam13406
749222004099	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
749222004100	N-acetyl-D-glucosamine binding site [chemical binding]; other site
749222004101	catalytic residue [active]
749222004102	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
749222004103	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
749222004104	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
749222004105	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
749222004106	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
749222004107	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
749222004108	Methyltransferase domain; Region: Methyltransf_23; pfam13489
749222004109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222004110	S-adenosylmethionine binding site [chemical binding]; other site
749222004111	NnrS protein; Region: NnrS; cl01258
749222004112	NnrS protein; Region: NnrS; cl01258
749222004113	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
749222004114	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
749222004115	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
749222004116	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
749222004117	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
749222004118	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
749222004119	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
749222004120	Dodecin; Region: Dodecin; pfam07311
749222004121	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
749222004122	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
749222004123	active site
749222004124	thiamine phosphate binding site [chemical binding]; other site
749222004125	pyrophosphate binding site [ion binding]; other site
749222004126	Phospholipid methyltransferase; Region: PEMT; cl17370
749222004127	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
749222004128	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
749222004129	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
749222004130	catalytic residues [active]
749222004131	Cytochrome c; Region: Cytochrom_C; cl11414
749222004132	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222004133	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222004134	dimer interface [polypeptide binding]; other site
749222004135	phosphorylation site [posttranslational modification]
749222004136	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222004137	ATP binding site [chemical binding]; other site
749222004138	Mg2+ binding site [ion binding]; other site
749222004139	G-X-G motif; other site
749222004140	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222004141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222004142	active site
749222004143	phosphorylation site [posttranslational modification]
749222004144	intermolecular recognition site; other site
749222004145	dimerization interface [polypeptide binding]; other site
749222004146	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222004147	DNA binding site [nucleotide binding]
749222004148	thioredoxin 2; Provisional; Region: PRK10996
749222004149	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
749222004150	catalytic residues [active]
749222004151	Nitrate and nitrite sensing; Region: NIT; pfam08376
749222004152	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222004153	dimer interface [polypeptide binding]; other site
749222004154	phosphorylation site [posttranslational modification]
749222004155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222004156	ATP binding site [chemical binding]; other site
749222004157	Mg2+ binding site [ion binding]; other site
749222004158	G-X-G motif; other site
749222004159	Response regulator receiver domain; Region: Response_reg; pfam00072
749222004160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222004161	active site
749222004162	phosphorylation site [posttranslational modification]
749222004163	intermolecular recognition site; other site
749222004164	dimerization interface [polypeptide binding]; other site
749222004165	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
749222004166	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
749222004167	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
749222004168	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
749222004169	aspartate aminotransferase; Provisional; Region: PRK05764
749222004170	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
749222004171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222004172	homodimer interface [polypeptide binding]; other site
749222004173	catalytic residue [active]
749222004174	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
749222004175	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
749222004176	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
749222004177	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
749222004178	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
749222004179	Catalytic site [active]
749222004180	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
749222004181	Catalytic site [active]
749222004182	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
749222004183	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
749222004184	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
749222004185	Haem-binding domain; Region: Haem_bd; pfam14376
749222004186	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
749222004187	non-heme iron binding site [ion binding]; other site
749222004188	tetramer interface [polypeptide binding]; other site
749222004189	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
749222004190	Fe-S cluster binding site [ion binding]; other site
749222004191	active site
749222004192	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
749222004193	Putative phosphatase (DUF442); Region: DUF442; cl17385
749222004194	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
749222004195	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222004196	Walker A motif; other site
749222004197	ATP binding site [chemical binding]; other site
749222004198	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
749222004199	Walker B motif; other site
749222004200	arginine finger; other site
749222004201	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
749222004202	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
749222004203	active site
749222004204	HslU subunit interaction site [polypeptide binding]; other site
749222004205	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
749222004206	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
749222004207	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
749222004208	Protein of unknown function (DUF503); Region: DUF503; cl00669
749222004209	helicase 45; Provisional; Region: PTZ00424
749222004210	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
749222004211	ATP binding site [chemical binding]; other site
749222004212	Mg++ binding site [ion binding]; other site
749222004213	motif III; other site
749222004214	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
749222004215	nucleotide binding region [chemical binding]; other site
749222004216	ATP-binding site [chemical binding]; other site
749222004217	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
749222004218	Clp amino terminal domain; Region: Clp_N; pfam02861
749222004219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222004220	Walker A motif; other site
749222004221	ATP binding site [chemical binding]; other site
749222004222	Walker B motif; other site
749222004223	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222004224	Walker A motif; other site
749222004225	ATP binding site [chemical binding]; other site
749222004226	Walker B motif; other site
749222004227	arginine finger; other site
749222004228	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
749222004229	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
749222004230	C-terminal peptidase (prc); Region: prc; TIGR00225
749222004231	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
749222004232	protein binding site [polypeptide binding]; other site
749222004233	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
749222004234	Catalytic dyad [active]
749222004235	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
749222004236	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
749222004237	ATP binding site [chemical binding]; other site
749222004238	active site
749222004239	substrate binding site [chemical binding]; other site
749222004240	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
749222004241	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
749222004242	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
749222004243	putative active site [active]
749222004244	catalytic triad [active]
749222004245	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
749222004246	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
749222004247	putative acyl-acceptor binding pocket; other site
749222004248	GAF domain; Region: GAF; pfam01590
749222004249	GAF domain; Region: GAF_2; pfam13185
749222004250	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222004251	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222004252	dimer interface [polypeptide binding]; other site
749222004253	phosphorylation site [posttranslational modification]
749222004254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222004255	ATP binding site [chemical binding]; other site
749222004256	Mg2+ binding site [ion binding]; other site
749222004257	G-X-G motif; other site
749222004258	Response regulator receiver domain; Region: Response_reg; pfam00072
749222004259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222004260	active site
749222004261	phosphorylation site [posttranslational modification]
749222004262	intermolecular recognition site; other site
749222004263	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
749222004264	PAS domain; Region: PAS_9; pfam13426
749222004265	putative active site [active]
749222004266	heme pocket [chemical binding]; other site
749222004267	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
749222004268	catalytic core [active]
749222004269	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
749222004270	active site
749222004271	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
749222004272	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
749222004273	active site
749222004274	NifU-like domain; Region: NifU; cl00484
749222004275	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
749222004276	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
749222004277	DNA binding site [nucleotide binding]
749222004278	active site
749222004279	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
749222004280	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
749222004281	Ligand Binding Site [chemical binding]; other site
749222004282	metal-binding heat shock protein; Provisional; Region: PRK00016
749222004283	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
749222004284	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
749222004285	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
749222004286	GTP-binding protein YchF; Reviewed; Region: PRK09601
749222004287	YchF GTPase; Region: YchF; cd01900
749222004288	G1 box; other site
749222004289	GTP/Mg2+ binding site [chemical binding]; other site
749222004290	Switch I region; other site
749222004291	G2 box; other site
749222004292	Switch II region; other site
749222004293	G3 box; other site
749222004294	G4 box; other site
749222004295	G5 box; other site
749222004296	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
749222004297	Domain of unknown function DUF302; Region: DUF302; pfam03625
749222004298	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
749222004299	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
749222004300	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
749222004301	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
749222004302	catalytic residues [active]
749222004303	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
749222004304	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
749222004305	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
749222004306	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
749222004307	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
749222004308	diaminopimelate decarboxylase; Region: lysA; TIGR01048
749222004309	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841
749222004310	dimer interface [polypeptide binding]; other site
749222004311	active site
749222004312	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
749222004313	catalytic residues [active]
749222004314	substrate binding site [chemical binding]; other site
749222004315	Urea transporter; Region: UT; pfam03253
749222004316	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
749222004317	Peptidase family M23; Region: Peptidase_M23; pfam01551
749222004318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
749222004319	binding surface
749222004320	TPR motif; other site
749222004321	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
749222004322	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
749222004323	ATP binding site [chemical binding]; other site
749222004324	putative Mg++ binding site [ion binding]; other site
749222004325	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
749222004326	nucleotide binding region [chemical binding]; other site
749222004327	ATP-binding site [chemical binding]; other site
749222004328	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
749222004329	HRDC domain; Region: HRDC; pfam00570
749222004330	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
749222004331	Sel1-like repeats; Region: SEL1; smart00671
749222004332	Sel1-like repeats; Region: SEL1; smart00671
749222004333	Sel1-like repeats; Region: SEL1; smart00671
749222004334	Sel1-like repeats; Region: SEL1; smart00671
749222004335	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
749222004336	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
749222004337	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
749222004338	metal binding triad [ion binding]; metal-binding site
749222004339	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
749222004340	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222004341	Walker A motif; other site
749222004342	ATP binding site [chemical binding]; other site
749222004343	Walker B motif; other site
749222004344	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
749222004345	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
749222004346	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
749222004347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
749222004348	binding surface
749222004349	TPR motif; other site
749222004350	translocation protein TolB; Provisional; Region: tolB; PRK04043
749222004351	TolB amino-terminal domain; Region: TolB_N; pfam04052
749222004352	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
749222004353	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
749222004354	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
749222004355	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
749222004356	active site
749222004357	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
749222004358	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
749222004359	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
749222004360	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
749222004361	ligand binding site [chemical binding]; other site
749222004362	short chain dehydrogenase; Validated; Region: PRK06182
749222004363	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
749222004364	NADP binding site [chemical binding]; other site
749222004365	active site
749222004366	steroid binding site; other site
749222004367	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
749222004368	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
749222004369	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
749222004370	heme-binding site [chemical binding]; other site
749222004371	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
749222004372	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
749222004373	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
749222004374	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
749222004375	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
749222004376	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
749222004377	Cytochrome c; Region: Cytochrom_C; pfam00034
749222004378	Reduced folate carrier; Region: Folate_carrier; pfam01770
749222004379	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
749222004380	Transglycosylase; Region: Transgly; pfam00912
749222004381	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
749222004382	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
749222004383	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
749222004384	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
749222004385	Walker A/P-loop; other site
749222004386	ATP binding site [chemical binding]; other site
749222004387	Q-loop/lid; other site
749222004388	ABC transporter signature motif; other site
749222004389	Walker B; other site
749222004390	D-loop; other site
749222004391	H-loop/switch region; other site
749222004392	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
749222004393	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
749222004394	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
749222004395	catalytic residue [active]
749222004396	Maf-like protein; Reviewed; Region: PRK04056
749222004397	Maf-like protein; Region: Maf; pfam02545
749222004398	putative active site [active]
749222004399	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
749222004400	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
749222004401	motif 1; other site
749222004402	active site
749222004403	motif 2; other site
749222004404	motif 3; other site
749222004405	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
749222004406	DHHA1 domain; Region: DHHA1; pfam02272
749222004407	NAD synthetase; Reviewed; Region: nadE; PRK02628
749222004408	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
749222004409	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
749222004410	homodimer interface [polypeptide binding]; other site
749222004411	active site
749222004412	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
749222004413	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
749222004414	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
749222004415	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
749222004416	pantoate--beta-alanine ligase; Region: panC; TIGR00018
749222004417	Pantoate-beta-alanine ligase; Region: PanC; cd00560
749222004418	active site
749222004419	ATP-binding site [chemical binding]; other site
749222004420	pantoate-binding site; other site
749222004421	HXXH motif; other site
749222004422	peptide chain release factor 2; Validated; Region: prfB; PRK00578
749222004423	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
749222004424	This domain is found in peptide chain release factors; Region: PCRF; smart00937
749222004425	RF-1 domain; Region: RF-1; pfam00472
749222004426	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
749222004427	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
749222004428	Walker A/P-loop; other site
749222004429	ATP binding site [chemical binding]; other site
749222004430	Q-loop/lid; other site
749222004431	ABC transporter signature motif; other site
749222004432	Walker B; other site
749222004433	D-loop; other site
749222004434	H-loop/switch region; other site
749222004435	elongation factor Ts; Provisional; Region: tsf; PRK09377
749222004436	UBA/TS-N domain; Region: UBA; pfam00627
749222004437	Elongation factor TS; Region: EF_TS; pfam00889
749222004438	Elongation factor TS; Region: EF_TS; pfam00889
749222004439	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
749222004440	rRNA interaction site [nucleotide binding]; other site
749222004441	S8 interaction site; other site
749222004442	putative laminin-1 binding site; other site
749222004443	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
749222004444	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
749222004445	catalytic triad [active]
749222004446	Protein of unknown function (DUF523); Region: DUF523; pfam04463
749222004447	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
749222004448	Transposase IS200 like; Region: Y1_Tnp; pfam01797
749222004449	Protein of unknown function (DUF420); Region: DUF420; cl00989
749222004450	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
749222004451	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
749222004452	NAD(P) binding site [chemical binding]; other site
749222004453	catalytic residues [active]
749222004454	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
749222004455	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
749222004456	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
749222004457	NapD protein; Region: NapD; pfam03927
749222004458	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
749222004459	FOG: WD40 repeat [General function prediction only]; Region: COG2319
749222004460	structural tetrad; other site
749222004461	4Fe-4S binding domain; Region: Fer4; pfam00037
749222004462	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
749222004463	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
749222004464	4Fe-4S binding domain; Region: Fer4_5; pfam12801
749222004465	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
749222004466	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
749222004467	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
749222004468	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
749222004469	molybdopterin cofactor binding site; other site
749222004470	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
749222004471	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
749222004472	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
749222004473	molybdopterin cofactor binding site; other site
749222004474	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
749222004475	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
749222004476	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
749222004477	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
749222004478	ligand binding site [chemical binding]; other site
749222004479	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
749222004480	non-specific DNA interactions [nucleotide binding]; other site
749222004481	DNA binding site [nucleotide binding]
749222004482	sequence specific DNA binding site [nucleotide binding]; other site
749222004483	putative cAMP binding site [chemical binding]; other site
749222004484	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
749222004485	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
749222004486	active site
749222004487	SAM binding site [chemical binding]; other site
749222004488	homodimer interface [polypeptide binding]; other site
749222004489	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
749222004490	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222004491	FeS/SAM binding site; other site
749222004492	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
749222004493	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
749222004494	Cytochrome c; Region: Cytochrom_C; pfam00034
749222004495	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
749222004496	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
749222004497	Paraquat-inducible protein A; Region: PqiA; pfam04403
749222004498	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
749222004499	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
749222004500	Paraquat-inducible protein A; Region: PqiA; pfam04403
749222004501	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
749222004502	mce related protein; Region: MCE; pfam02470
749222004503	mce related protein; Region: MCE; pfam02470
749222004504	mce related protein; Region: MCE; pfam02470
749222004505	Protein of unknown function (DUF330); Region: DUF330; pfam03886
749222004506	Response regulator receiver domain; Region: Response_reg; pfam00072
749222004507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222004508	active site
749222004509	phosphorylation site [posttranslational modification]
749222004510	intermolecular recognition site; other site
749222004511	dimerization interface [polypeptide binding]; other site
749222004512	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
749222004513	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
749222004514	metal binding site [ion binding]; metal-binding site
749222004515	active site
749222004516	I-site; other site
749222004517	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
749222004518	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
749222004519	substrate binding pocket [chemical binding]; other site
749222004520	membrane-bound complex binding site; other site
749222004521	hinge residues; other site
749222004522	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
749222004523	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
749222004524	substrate binding pocket [chemical binding]; other site
749222004525	membrane-bound complex binding site; other site
749222004526	hinge residues; other site
749222004527	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222004528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222004529	dimer interface [polypeptide binding]; other site
749222004530	phosphorylation site [posttranslational modification]
749222004531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222004532	ATP binding site [chemical binding]; other site
749222004533	Mg2+ binding site [ion binding]; other site
749222004534	G-X-G motif; other site
749222004535	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
749222004536	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
749222004537	active site
749222004538	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
749222004539	thiS-thiF/thiG interaction site; other site
749222004540	Uncharacterized conserved protein [Function unknown]; Region: COG1565
749222004541	Outer membrane efflux protein; Region: OEP; pfam02321
749222004542	acetylornithine aminotransferase; Provisional; Region: PRK02627
749222004543	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
749222004544	inhibitor-cofactor binding pocket; inhibition site
749222004545	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222004546	catalytic residue [active]
749222004547	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
749222004548	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
749222004549	Cl- selectivity filter; other site
749222004550	Cl- binding residues [ion binding]; other site
749222004551	pore gating glutamate residue; other site
749222004552	dimer interface [polypeptide binding]; other site
749222004553	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
749222004554	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
749222004555	active site
749222004556	nucleotide binding site [chemical binding]; other site
749222004557	HIGH motif; other site
749222004558	KMSKS motif; other site
749222004559	Riboflavin kinase; Region: Flavokinase; pfam01687
749222004560	Uncharacterized conserved protein [Function unknown]; Region: COG5316
749222004561	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
749222004562	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
749222004563	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
749222004564	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
749222004565	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
749222004566	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
749222004567	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222004568	HAMP domain; Region: HAMP; pfam00672
749222004569	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222004570	dimer interface [polypeptide binding]; other site
749222004571	phosphorylation site [posttranslational modification]
749222004572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222004573	ATP binding site [chemical binding]; other site
749222004574	Mg2+ binding site [ion binding]; other site
749222004575	G-X-G motif; other site
749222004576	Response regulator receiver domain; Region: Response_reg; pfam00072
749222004577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222004578	active site
749222004579	phosphorylation site [posttranslational modification]
749222004580	intermolecular recognition site; other site
749222004581	dimerization interface [polypeptide binding]; other site
749222004582	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
749222004583	metal binding site [ion binding]; metal-binding site
749222004584	active site
749222004585	I-site; other site
749222004586	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
749222004587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
749222004588	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
749222004589	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
749222004590	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
749222004591	Protein of unknown function (DUF2743); Region: DUF2743; pfam10899
749222004592	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
749222004593	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
749222004594	Uncharacterized protein family (UPF0128); Region: UPF0128; cl00799
749222004595	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
749222004596	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
749222004597	RNA binding surface [nucleotide binding]; other site
749222004598	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222004599	S-adenosylmethionine binding site [chemical binding]; other site
749222004600	glutamate racemase; Provisional; Region: PRK00865
749222004601	hypothetical protein; Reviewed; Region: PRK12275
749222004602	four helix bundle protein; Region: TIGR02436
749222004603	transcription termination factor Rho; Provisional; Region: rho; PRK09376
749222004604	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
749222004605	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
749222004606	RNA binding site [nucleotide binding]; other site
749222004607	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
749222004608	multimer interface [polypeptide binding]; other site
749222004609	Walker A motif; other site
749222004610	ATP binding site [chemical binding]; other site
749222004611	Walker B motif; other site
749222004612	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
749222004613	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
749222004614	metal binding site [ion binding]; metal-binding site
749222004615	dimer interface [polypeptide binding]; other site
749222004616	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
749222004617	active site residue [active]
749222004618	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
749222004619	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
749222004620	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
749222004621	Walker A motif; other site
749222004622	ATP binding site [chemical binding]; other site
749222004623	Walker B motif; other site
749222004624	Colicin V production protein; Region: Colicin_V; pfam02674
749222004625	ferric uptake regulator; Provisional; Region: fur; PRK09462
749222004626	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
749222004627	metal binding site 2 [ion binding]; metal-binding site
749222004628	putative DNA binding helix; other site
749222004629	metal binding site 1 [ion binding]; metal-binding site
749222004630	dimer interface [polypeptide binding]; other site
749222004631	structural Zn2+ binding site [ion binding]; other site
749222004632	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
749222004633	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
749222004634	dimer interface [polypeptide binding]; other site
749222004635	putative anticodon binding site; other site
749222004636	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
749222004637	motif 1; other site
749222004638	active site
749222004639	motif 2; other site
749222004640	motif 3; other site
749222004641	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
749222004642	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
749222004643	dimer interface [polypeptide binding]; other site
749222004644	active site
749222004645	glycine-pyridoxal phosphate binding site [chemical binding]; other site
749222004646	folate binding site [chemical binding]; other site
749222004647	Domain of unknown function (DUF1882); Region: DUF1882; pfam08966
749222004648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
749222004649	Sporulation related domain; Region: SPOR; pfam05036
749222004650	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
749222004651	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
749222004652	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
749222004653	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
749222004654	active site
749222004655	dimer interface [polypeptide binding]; other site
749222004656	magnesium binding site [ion binding]; other site
749222004657	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
749222004658	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
749222004659	tetramer interface [polypeptide binding]; other site
749222004660	active site
749222004661	Domain of unknown function DUF302; Region: DUF302; pfam03625
749222004662	Domain of unknown function DUF59; Region: DUF59; pfam01883
749222004663	antiporter inner membrane protein; Provisional; Region: PRK11670
749222004664	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
749222004665	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
749222004666	ThiC family; Region: ThiC; pfam01964
749222004667	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
749222004668	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
749222004669	substrate binding site; other site
749222004670	dimer interface; other site
749222004671	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
749222004672	homotrimer interaction site [polypeptide binding]; other site
749222004673	zinc binding site [ion binding]; other site
749222004674	CDP-binding sites; other site
749222004675	Response regulator receiver domain; Region: Response_reg; pfam00072
749222004676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222004677	active site
749222004678	phosphorylation site [posttranslational modification]
749222004679	intermolecular recognition site; other site
749222004680	dimerization interface [polypeptide binding]; other site
749222004681	ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046
749222004682	PUA-like domain; Region: PUA_2; pfam14306
749222004683	ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747
749222004684	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
749222004685	tetramer interfaces [polypeptide binding]; other site
749222004686	binuclear metal-binding site [ion binding]; other site
749222004687	Transposase IS200 like; Region: Y1_Tnp; pfam01797
749222004688	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
749222004689	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
749222004690	Repair protein; Region: Repair_PSII; pfam04536
749222004691	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
749222004692	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
749222004693	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
749222004694	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
749222004695	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
749222004696	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
749222004697	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
749222004698	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
749222004699	metal-binding site [ion binding]
749222004700	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
749222004701	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222004702	motif II; other site
749222004703	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
749222004704	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
749222004705	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
749222004706	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
749222004707	putative acyl-acceptor binding pocket; other site
749222004708	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
749222004709	active site
749222004710	catalytic site [active]
749222004711	substrate binding site [chemical binding]; other site
749222004712	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
749222004713	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
749222004714	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
749222004715	putative active site [active]
749222004716	oxyanion strand; other site
749222004717	catalytic triad [active]
749222004718	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
749222004719	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
749222004720	catalytic residues [active]
749222004721	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
749222004722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222004723	S-adenosylmethionine binding site [chemical binding]; other site
749222004724	FtsH Extracellular; Region: FtsH_ext; pfam06480
749222004725	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
749222004726	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
749222004727	Walker A motif; other site
749222004728	ATP binding site [chemical binding]; other site
749222004729	Walker B motif; other site
749222004730	arginine finger; other site
749222004731	Peptidase family M41; Region: Peptidase_M41; pfam01434
749222004732	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
749222004733	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
749222004734	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
749222004735	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
749222004736	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
749222004737	S-ribosylhomocysteinase; Provisional; Region: PRK02260
749222004738	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
749222004739	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
749222004740	generic binding surface II; other site
749222004741	generic binding surface I; other site
749222004742	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
749222004743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222004744	S-adenosylmethionine binding site [chemical binding]; other site
749222004745	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
749222004746	catalytic motif [active]
749222004747	Zn binding site [ion binding]; other site
749222004748	RibD C-terminal domain; Region: RibD_C; cl17279
749222004749	Protein of unknown function DUF72; Region: DUF72; pfam01904
749222004750	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
749222004751	substrate binding site [chemical binding]; other site
749222004752	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
749222004753	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
749222004754	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
749222004755	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
749222004756	active site
749222004757	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
749222004758	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
749222004759	substrate binding pocket [chemical binding]; other site
749222004760	membrane-bound complex binding site; other site
749222004761	hinge residues; other site
749222004762	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
749222004763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
749222004764	conserved gate region; other site
749222004765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
749222004766	putative PBP binding loops; other site
749222004767	ABC-ATPase subunit interface; other site
749222004768	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
749222004769	dimer interface [polypeptide binding]; other site
749222004770	conserved gate region; other site
749222004771	putative PBP binding loops; other site
749222004772	ABC-ATPase subunit interface; other site
749222004773	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
749222004774	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
749222004775	Walker A/P-loop; other site
749222004776	ATP binding site [chemical binding]; other site
749222004777	Q-loop/lid; other site
749222004778	ABC transporter signature motif; other site
749222004779	Walker B; other site
749222004780	D-loop; other site
749222004781	H-loop/switch region; other site
749222004782	Predicted membrane protein [Function unknown]; Region: COG2860
749222004783	UPF0126 domain; Region: UPF0126; pfam03458
749222004784	UPF0126 domain; Region: UPF0126; pfam03458
749222004785	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
749222004786	Hpr binding site; other site
749222004787	active site
749222004788	homohexamer subunit interaction site [polypeptide binding]; other site
749222004789	H-type lectin domain; Region: H_lectin; pfam09458
749222004790	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
749222004791	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
749222004792	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
749222004793	active site
749222004794	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
749222004795	active site
749222004796	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
749222004797	homodimer interface [polypeptide binding]; other site
749222004798	putative glycosyl transferase; Provisional; Region: PRK10307
749222004799	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
749222004800	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
749222004801	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
749222004802	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653
749222004803	putative active site [active]
749222004804	putative cosubstrate binding site; other site
749222004805	putative substrate binding site [chemical binding]; other site
749222004806	catalytic site [active]
749222004807	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
749222004808	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
749222004809	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
749222004810	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
749222004811	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
749222004812	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
749222004813	trimer interface [polypeptide binding]; other site
749222004814	active site
749222004815	substrate binding site [chemical binding]; other site
749222004816	CoA binding site [chemical binding]; other site
749222004817	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
749222004818	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
749222004819	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
749222004820	O-Antigen ligase; Region: Wzy_C; pfam04932
749222004821	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
749222004822	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
749222004823	active site
749222004824	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
749222004825	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
749222004826	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
749222004827	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
749222004828	active site
749222004829	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
749222004830	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
749222004831	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
749222004832	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
749222004833	trimer interface [polypeptide binding]; other site
749222004834	active site
749222004835	substrate binding site [chemical binding]; other site
749222004836	CoA binding site [chemical binding]; other site
749222004837	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
749222004838	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
749222004839	inhibitor-cofactor binding pocket; inhibition site
749222004840	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222004841	catalytic residue [active]
749222004842	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
749222004843	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
749222004844	NAD binding site [chemical binding]; other site
749222004845	substrate binding site [chemical binding]; other site
749222004846	homodimer interface [polypeptide binding]; other site
749222004847	active site
749222004848	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
749222004849	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
749222004850	substrate binding site; other site
749222004851	tetramer interface; other site
749222004852	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
749222004853	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
749222004854	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
749222004855	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
749222004856	tyrosine kinase; Provisional; Region: PRK11519
749222004857	Chain length determinant protein; Region: Wzz; pfam02706
749222004858	RTX N-terminal domain; Region: RTX; pfam02382
749222004859	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
749222004860	Chain length determinant protein; Region: Wzz; cl15801
749222004861	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
749222004862	P-loop; other site
749222004863	Magnesium ion binding site [ion binding]; other site
749222004864	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
749222004865	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
749222004866	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
749222004867	SLBB domain; Region: SLBB; pfam10531
749222004868	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
749222004869	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
749222004870	Mg++ binding site [ion binding]; other site
749222004871	putative catalytic motif [active]
749222004872	substrate binding site [chemical binding]; other site
749222004873	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
749222004874	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
749222004875	DEAD-like helicases superfamily; Region: DEXDc; smart00487
749222004876	ATP binding site [chemical binding]; other site
749222004877	Mg++ binding site [ion binding]; other site
749222004878	motif III; other site
749222004879	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
749222004880	nucleotide binding region [chemical binding]; other site
749222004881	ATP-binding site [chemical binding]; other site
749222004882	Cytochrome c; Region: Cytochrom_C; cl11414
749222004883	DctM-like transporters; Region: DctM; pfam06808
749222004884	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
749222004885	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
749222004886	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
749222004887	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
749222004888	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
749222004889	Sel1 repeat; Region: Sel1; cl02723
749222004890	Sel1 repeat; Region: Sel1; cl02723
749222004891	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
749222004892	DctM-like transporters; Region: DctM; pfam06808
749222004893	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
749222004894	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
749222004895	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
749222004896	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
749222004897	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
749222004898	TPP-binding site [chemical binding]; other site
749222004899	putative dimer interface [polypeptide binding]; other site
749222004900	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
749222004901	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
749222004902	dimer interface [polypeptide binding]; other site
749222004903	PYR/PP interface [polypeptide binding]; other site
749222004904	TPP binding site [chemical binding]; other site
749222004905	substrate binding site [chemical binding]; other site
749222004906	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
749222004907	pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625
749222004908	4Fe-4S binding domain; Region: Fer4; pfam00037
749222004909	pyruvate flavodoxin oxidoreductase subunit gamma; Validated; Region: PRK05844
749222004910	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
749222004911	3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454
749222004912	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222004913	motif II; other site
749222004914	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
749222004915	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
749222004916	peptide binding site [polypeptide binding]; other site
749222004917	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
749222004918	Polypeptide deformylase; Region: Pep_deformylase; pfam01327
749222004919	active site
749222004920	catalytic residues [active]
749222004921	metal binding site [ion binding]; metal-binding site
749222004922	thiosulfate reductase PhsA; Provisional; Region: PRK15488
749222004923	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
749222004924	putative [Fe4-S4] binding site [ion binding]; other site
749222004925	putative molybdopterin cofactor binding site [chemical binding]; other site
749222004926	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
749222004927	putative molybdopterin cofactor binding site; other site
749222004928	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
749222004929	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
749222004930	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
749222004931	integrase; Provisional; Region: PRK09692
749222004932	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
749222004933	active site
749222004934	Int/Topo IB signature motif; other site
749222004935	Homeodomain-like domain; Region: HTH_23; cl17451
749222004936	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
749222004937	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
749222004938	TIGR02594 family protein; Region: TIGR02594
749222004939	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
749222004940	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
749222004941	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
749222004942	Phage tail tube protein FII; Region: Phage_tube; cl01390
749222004943	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
749222004944	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
749222004945	Baseplate J-like protein; Region: Baseplate_J; cl01294
749222004946	Baseplate J-like protein; Region: Baseplate_J; cl01294
749222004947	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
749222004948	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
749222004949	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
749222004950	Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289
749222004951	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
749222004952	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
749222004953	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
749222004954	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
749222004955	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
749222004956	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
749222004957	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
749222004958	active site
749222004959	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
749222004960	Predicted transcriptional regulator [Transcription]; Region: COG2932
749222004961	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
749222004962	Catalytic site [active]
749222004963	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
749222004964	ERF superfamily; Region: ERF; pfam04404
749222004965	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
749222004966	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
749222004967	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
749222004968	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
749222004969	dimer interface [polypeptide binding]; other site
749222004970	ssDNA binding site [nucleotide binding]; other site
749222004971	tetramer (dimer of dimers) interface [polypeptide binding]; other site
749222004972	DNA methylase; Region: N6_N4_Mtase; pfam01555
749222004973	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
749222004974	Phage terminase, small subunit; Region: Terminase_4; cl01525
749222004975	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
749222004976	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
749222004977	cofactor binding site; other site
749222004978	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
749222004979	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
749222004980	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
749222004981	G1 box; other site
749222004982	putative GEF interaction site [polypeptide binding]; other site
749222004983	GTP/Mg2+ binding site [chemical binding]; other site
749222004984	Switch I region; other site
749222004985	G2 box; other site
749222004986	G3 box; other site
749222004987	Switch II region; other site
749222004988	G4 box; other site
749222004989	G5 box; other site
749222004990	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
749222004991	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
749222004992	selenocysteine synthase; Provisional; Region: PRK04311
749222004993	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
749222004994	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
749222004995	DsrE/DsrF-like family; Region: DrsE; pfam02635
749222004996	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
749222004997	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
749222004998	CPxP  motif; other site
749222004999	DsrE/DsrF-like family; Region: DrsE; pfam02635
749222005000	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
749222005001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
749222005002	Domain of unknown function DUF59; Region: DUF59; cl00941
749222005003	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
749222005004	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
749222005005	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
749222005006	NMT1/THI5 like; Region: NMT1; pfam09084
749222005007	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
749222005008	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
749222005009	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
749222005010	dimer interface [polypeptide binding]; other site
749222005011	conserved gate region; other site
749222005012	putative PBP binding loops; other site
749222005013	ABC-ATPase subunit interface; other site
749222005014	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
749222005015	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
749222005016	Walker A/P-loop; other site
749222005017	ATP binding site [chemical binding]; other site
749222005018	Q-loop/lid; other site
749222005019	ABC transporter signature motif; other site
749222005020	Walker B; other site
749222005021	D-loop; other site
749222005022	H-loop/switch region; other site
749222005023	NnrS protein; Region: NnrS; pfam05940
749222005024	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
749222005025	SirA-like protein; Region: SirA; pfam01206
749222005026	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
749222005027	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
749222005028	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
749222005029	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
749222005030	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
749222005031	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
749222005032	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
749222005033	NADH dehydrogenase; Region: NADHdh; cl00469
749222005034	hydrogenase 4 subunit B; Validated; Region: PRK06521
749222005035	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
749222005036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
749222005037	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
749222005038	homoserine dehydrogenase; Provisional; Region: PRK06349
749222005039	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
749222005040	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
749222005041	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
749222005042	aspartate aminotransferase; Provisional; Region: PRK08636
749222005043	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
749222005044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222005045	homodimer interface [polypeptide binding]; other site
749222005046	catalytic residue [active]
749222005047	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
749222005048	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
749222005049	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
749222005050	Predicted methyltransferases [General function prediction only]; Region: COG0313
749222005051	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
749222005052	putative SAM binding site [chemical binding]; other site
749222005053	putative homodimer interface [polypeptide binding]; other site
749222005054	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
749222005055	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
749222005056	RNA methyltransferase, RsmE family; Region: TIGR00046
749222005057	Cytochrome c; Region: Cytochrom_C; cl11414
749222005058	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
749222005059	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222005060	FeS/SAM binding site; other site
749222005061	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
749222005062	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222005063	FeS/SAM binding site; other site
749222005064	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
749222005065	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
749222005066	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
749222005067	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
749222005068	intrachain domain interface; other site
749222005069	interchain domain interface [polypeptide binding]; other site
749222005070	heme bH binding site [chemical binding]; other site
749222005071	Qi binding site; other site
749222005072	heme bL binding site [chemical binding]; other site
749222005073	Qo binding site; other site
749222005074	interchain domain interface [polypeptide binding]; other site
749222005075	intrachain domain interface; other site
749222005076	Qi binding site; other site
749222005077	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
749222005078	Qo binding site; other site
749222005079	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
749222005080	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
749222005081	iron-sulfur cluster [ion binding]; other site
749222005082	[2Fe-2S] cluster binding site [ion binding]; other site
749222005083	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
749222005084	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
749222005085	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
749222005086	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
749222005087	Lumazine binding domain; Region: Lum_binding; pfam00677
749222005088	Lumazine binding domain; Region: Lum_binding; pfam00677
749222005089	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
749222005090	Transposase IS200 like; Region: Y1_Tnp; pfam01797
749222005091	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
749222005092	non-specific DNA binding site [nucleotide binding]; other site
749222005093	salt bridge; other site
749222005094	sequence-specific DNA binding site [nucleotide binding]; other site
749222005095	Restriction endonuclease; Region: Mrr_cat; pfam04471
749222005096	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
749222005097	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
749222005098	nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890
749222005099	Cupin domain; Region: Cupin_2; pfam07883
749222005100	2-isopropylmalate synthase; Validated; Region: PRK00915
749222005101	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
749222005102	active site
749222005103	catalytic residues [active]
749222005104	metal binding site [ion binding]; metal-binding site
749222005105	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
749222005106	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
749222005107	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
749222005108	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
749222005109	dimer interface [polypeptide binding]; other site
749222005110	ssDNA binding site [nucleotide binding]; other site
749222005111	tetramer (dimer of dimers) interface [polypeptide binding]; other site
749222005112	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
749222005113	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
749222005114	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
749222005115	Walker A/P-loop; other site
749222005116	ATP binding site [chemical binding]; other site
749222005117	Q-loop/lid; other site
749222005118	ABC transporter signature motif; other site
749222005119	Walker B; other site
749222005120	D-loop; other site
749222005121	H-loop/switch region; other site
749222005122	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
749222005123	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
749222005124	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
749222005125	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
749222005126	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
749222005127	RNA binding surface [nucleotide binding]; other site
749222005128	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
749222005129	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
749222005130	putative trimer interface [polypeptide binding]; other site
749222005131	putative CoA binding site [chemical binding]; other site
749222005132	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
749222005133	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
749222005134	N-terminal plug; other site
749222005135	ligand-binding site [chemical binding]; other site
749222005136	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
749222005137	putative ADP-ribose binding site [chemical binding]; other site
749222005138	putative active site [active]
749222005139	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
749222005140	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
749222005141	molybdopterin cofactor binding site; other site
749222005142	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
749222005143	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
749222005144	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
749222005145	active site
749222005146	dimer interface [polypeptide binding]; other site
749222005147	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
749222005148	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
749222005149	dimer interface [polypeptide binding]; other site
749222005150	putative functional site; other site
749222005151	putative MPT binding site; other site
749222005152	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
749222005153	oligomerisation interface [polypeptide binding]; other site
749222005154	mobile loop; other site
749222005155	roof hairpin; other site
749222005156	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
749222005157	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
749222005158	ring oligomerisation interface [polypeptide binding]; other site
749222005159	ATP/Mg binding site [chemical binding]; other site
749222005160	stacking interactions; other site
749222005161	hinge regions; other site
749222005162	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
749222005163	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
749222005164	active site
749222005165	catalytic site [active]
749222005166	ribosome maturation protein RimP; Reviewed; Region: PRK00092
749222005167	Sm and related proteins; Region: Sm_like; cl00259
749222005168	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
749222005169	putative oligomer interface [polypeptide binding]; other site
749222005170	putative RNA binding site [nucleotide binding]; other site
749222005171	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
749222005172	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
749222005173	translation initiation factor IF-2; Region: IF-2; TIGR00487
749222005174	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
749222005175	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
749222005176	G1 box; other site
749222005177	putative GEF interaction site [polypeptide binding]; other site
749222005178	GTP/Mg2+ binding site [chemical binding]; other site
749222005179	Switch I region; other site
749222005180	G2 box; other site
749222005181	G3 box; other site
749222005182	Switch II region; other site
749222005183	G4 box; other site
749222005184	G5 box; other site
749222005185	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
749222005186	Translation-initiation factor 2; Region: IF-2; pfam11987
749222005187	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
749222005188	Protein of unknown function (DUF448); Region: DUF448; pfam04296
749222005189	putative RNA binding cleft [nucleotide binding]; other site
749222005190	homoserine kinase; Region: thrB; TIGR00191
749222005191	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
749222005192	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
749222005193	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
749222005194	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
749222005195	Peptidase family M23; Region: Peptidase_M23; pfam01551
749222005196	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
749222005197	DHH family; Region: DHH; pfam01368
749222005198	DHHA1 domain; Region: DHHA1; pfam02272
749222005199	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848
749222005200	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
749222005201	dimerization interface [polypeptide binding]; other site
749222005202	active site
749222005203	quinolinate synthetase; Provisional; Region: PRK09375
749222005204	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
749222005205	Dihydroneopterin aldolase; Region: FolB; pfam02152
749222005206	active site
749222005207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
749222005208	Major Facilitator Superfamily; Region: MFS_1; pfam07690
749222005209	putative substrate translocation pore; other site
749222005210	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222005211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222005212	active site
749222005213	phosphorylation site [posttranslational modification]
749222005214	intermolecular recognition site; other site
749222005215	dimerization interface [polypeptide binding]; other site
749222005216	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222005217	DNA binding site [nucleotide binding]
749222005218	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
749222005219	HAMP domain; Region: HAMP; pfam00672
749222005220	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222005221	dimer interface [polypeptide binding]; other site
749222005222	phosphorylation site [posttranslational modification]
749222005223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222005224	ATP binding site [chemical binding]; other site
749222005225	Mg2+ binding site [ion binding]; other site
749222005226	G-X-G motif; other site
749222005227	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
749222005228	exopolyphosphatase; Region: exo_poly_only; TIGR03706
749222005229	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
749222005230	nucleotide binding site [chemical binding]; other site
749222005231	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
749222005232	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
749222005233	active site
749222005234	domain interfaces; other site
749222005235	Rhomboid family; Region: Rhomboid; pfam01694
749222005236	Class I aldolases; Region: Aldolase_Class_I; cl17187
749222005237	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
749222005238	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
749222005239	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
749222005240	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
749222005241	dimerization interface [polypeptide binding]; other site
749222005242	active site
749222005243	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
749222005244	dimer interface [polypeptide binding]; other site
749222005245	active site
749222005246	Schiff base residues; other site
749222005247	glutamate dehydrogenase; Provisional; Region: PRK09414
749222005248	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
749222005249	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
749222005250	NAD(P) binding site [chemical binding]; other site
749222005251	MASE1; Region: MASE1; cl17823
749222005252	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
749222005253	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
749222005254	metal binding site [ion binding]; metal-binding site
749222005255	active site
749222005256	I-site; other site
749222005257	Predicted permease; Region: DUF318; cl17795
749222005258	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
749222005259	putative active site; other site
749222005260	putative metal binding residues [ion binding]; other site
749222005261	signature motif; other site
749222005262	putative triphosphate binding site [ion binding]; other site
749222005263	CHAD domain; Region: CHAD; pfam05235
749222005264	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
749222005265	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
749222005266	23S rRNA interface [nucleotide binding]; other site
749222005267	L3 interface [polypeptide binding]; other site
749222005268	Part of AAA domain; Region: AAA_19; pfam13245
749222005269	putative recombination protein RecB; Provisional; Region: PRK13909
749222005270	Family description; Region: UvrD_C_2; pfam13538
749222005271	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
749222005272	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
749222005273	FixH; Region: FixH; pfam05751
749222005274	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
749222005275	Family of unknown function (DUF4006); Region: DUF4006; pfam13179
749222005276	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
749222005277	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
749222005278	Cytochrome c; Region: Cytochrom_C; pfam00034
749222005279	cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736
749222005280	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
749222005281	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
749222005282	cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488
749222005283	Low-spin heme binding site [chemical binding]; other site
749222005284	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
749222005285	D-pathway; other site
749222005286	Putative water exit pathway; other site
749222005287	Binuclear center (active site) [active]
749222005288	K-pathway; other site
749222005289	Putative proton exit pathway; other site
749222005290	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
749222005291	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
749222005292	ATP-grasp domain; Region: ATP-grasp_4; cl17255
749222005293	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
749222005294	Helix-hairpin-helix motif; Region: HHH; pfam00633
749222005295	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
749222005296	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
749222005297	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
749222005298	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
749222005299	catalytic site [active]
749222005300	subunit interface [polypeptide binding]; other site
749222005301	Protein of unknown function (DUF507); Region: DUF507; pfam04368
749222005302	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
749222005303	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
749222005304	GDP-binding site [chemical binding]; other site
749222005305	ACT binding site; other site
749222005306	IMP binding site; other site
749222005307	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12293
749222005308	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
749222005309	motif 1; other site
749222005310	dimer interface [polypeptide binding]; other site
749222005311	active site
749222005312	motif 2; other site
749222005313	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
749222005314	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
749222005315	catalytic residue [active]
749222005316	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
749222005317	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
749222005318	minor groove reading motif; other site
749222005319	helix-hairpin-helix signature motif; other site
749222005320	substrate binding pocket [chemical binding]; other site
749222005321	active site
749222005322	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
749222005323	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
749222005324	active site
749222005325	dimerization interface [polypeptide binding]; other site
749222005326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
749222005327	Major Facilitator Superfamily; Region: MFS_1; pfam07690
749222005328	putative substrate translocation pore; other site
749222005329	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
749222005330	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
749222005331	TPP-binding site [chemical binding]; other site
749222005332	dimer interface [polypeptide binding]; other site
749222005333	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
749222005334	PYR/PP interface [polypeptide binding]; other site
749222005335	dimer interface [polypeptide binding]; other site
749222005336	TPP binding site [chemical binding]; other site
749222005337	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
749222005338	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
749222005339	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
749222005340	substrate binding pocket [chemical binding]; other site
749222005341	chain length determination region; other site
749222005342	substrate-Mg2+ binding site; other site
749222005343	catalytic residues [active]
749222005344	aspartate-rich region 1; other site
749222005345	active site lid residues [active]
749222005346	aspartate-rich region 2; other site
749222005347	shikimate kinase; Reviewed; Region: aroK; PRK00131
749222005348	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
749222005349	ADP binding site [chemical binding]; other site
749222005350	magnesium binding site [ion binding]; other site
749222005351	putative shikimate binding site; other site
749222005352	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
749222005353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
749222005354	NAD(P) binding site [chemical binding]; other site
749222005355	active site
749222005356	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
749222005357	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
749222005358	Cl- selectivity filter; other site
749222005359	Cl- binding residues [ion binding]; other site
749222005360	pore gating glutamate residue; other site
749222005361	dimer interface [polypeptide binding]; other site
749222005362	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
749222005363	Cl- selectivity filter; other site
749222005364	Cl- binding residues [ion binding]; other site
749222005365	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
749222005366	pore gating glutamate residue; other site
749222005367	dimer interface [polypeptide binding]; other site
749222005368	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
749222005369	FOG: CBS domain [General function prediction only]; Region: COG0517
749222005370	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
749222005371	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
749222005372	elongation factor G; Reviewed; Region: PRK00007
749222005373	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
749222005374	G1 box; other site
749222005375	putative GEF interaction site [polypeptide binding]; other site
749222005376	GTP/Mg2+ binding site [chemical binding]; other site
749222005377	Switch I region; other site
749222005378	G2 box; other site
749222005379	G3 box; other site
749222005380	Switch II region; other site
749222005381	G4 box; other site
749222005382	G5 box; other site
749222005383	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
749222005384	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
749222005385	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
749222005386	30S ribosomal protein S7; Validated; Region: PRK05302
749222005387	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
749222005388	S17 interaction site [polypeptide binding]; other site
749222005389	S8 interaction site; other site
749222005390	16S rRNA interaction site [nucleotide binding]; other site
749222005391	streptomycin interaction site [chemical binding]; other site
749222005392	23S rRNA interaction site [nucleotide binding]; other site
749222005393	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
749222005394	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
749222005395	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
749222005396	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
749222005397	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
749222005398	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
749222005399	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
749222005400	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
749222005401	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
749222005402	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
749222005403	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
749222005404	DNA binding site [nucleotide binding]
749222005405	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
749222005406	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
749222005407	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
749222005408	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
749222005409	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
749222005410	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
749222005411	RPB3 interaction site [polypeptide binding]; other site
749222005412	RPB1 interaction site [polypeptide binding]; other site
749222005413	RPB11 interaction site [polypeptide binding]; other site
749222005414	RPB10 interaction site [polypeptide binding]; other site
749222005415	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
749222005416	L11 interface [polypeptide binding]; other site
749222005417	putative EF-Tu interaction site [polypeptide binding]; other site
749222005418	putative EF-G interaction site [polypeptide binding]; other site
749222005419	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
749222005420	23S rRNA interface [nucleotide binding]; other site
749222005421	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
749222005422	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
749222005423	mRNA/rRNA interface [nucleotide binding]; other site
749222005424	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
749222005425	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
749222005426	23S rRNA interface [nucleotide binding]; other site
749222005427	L7/L12 interface [polypeptide binding]; other site
749222005428	putative thiostrepton binding site; other site
749222005429	L25 interface [polypeptide binding]; other site
749222005430	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
749222005431	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
749222005432	putative homodimer interface [polypeptide binding]; other site
749222005433	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
749222005434	heterodimer interface [polypeptide binding]; other site
749222005435	homodimer interface [polypeptide binding]; other site
749222005436	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
749222005437	elongation factor Tu; Reviewed; Region: PRK00049
749222005438	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
749222005439	G1 box; other site
749222005440	GEF interaction site [polypeptide binding]; other site
749222005441	GTP/Mg2+ binding site [chemical binding]; other site
749222005442	Switch I region; other site
749222005443	G2 box; other site
749222005444	G3 box; other site
749222005445	Switch II region; other site
749222005446	G4 box; other site
749222005447	G5 box; other site
749222005448	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
749222005449	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
749222005450	Antibiotic Binding Site [chemical binding]; other site
749222005451	Protein of unknown function (DUF328); Region: DUF328; cl01143
749222005452	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
749222005453	putative rRNA binding site [nucleotide binding]; other site
749222005454	Domain of unknown function (DUF309); Region: DUF309; pfam03745
749222005455	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
749222005456	Predicted transcriptional regulator [Transcription]; Region: COG2932
749222005457	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
749222005458	Catalytic site [active]
749222005459	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
749222005460	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
749222005461	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
749222005462	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
749222005463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222005464	Mg2+ binding site [ion binding]; other site
749222005465	G-X-G motif; other site
749222005466	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
749222005467	anchoring element; other site
749222005468	dimer interface [polypeptide binding]; other site
749222005469	ATP binding site [chemical binding]; other site
749222005470	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
749222005471	active site
749222005472	putative metal-binding site [ion binding]; other site
749222005473	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
749222005474	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
749222005475	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
749222005476	dimer interface [polypeptide binding]; other site
749222005477	putative functional site; other site
749222005478	putative MPT binding site; other site
749222005479	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
749222005480	MoaE homodimer interface [polypeptide binding]; other site
749222005481	MoaD interaction [polypeptide binding]; other site
749222005482	active site residues [active]
749222005483	ThiS family; Region: ThiS; pfam02597
749222005484	charged pocket; other site
749222005485	hydrophobic patch; other site
749222005486	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
749222005487	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
749222005488	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
749222005489	active site
749222005490	HIGH motif; other site
749222005491	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
749222005492	active site
749222005493	KMSKS motif; other site
749222005494	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
749222005495	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
749222005496	NAD(P) binding site [chemical binding]; other site
749222005497	homodimer interface [polypeptide binding]; other site
749222005498	substrate binding site [chemical binding]; other site
749222005499	active site
749222005500	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
749222005501	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
749222005502	inhibitor-cofactor binding pocket; inhibition site
749222005503	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222005504	catalytic residue [active]
749222005505	Bacterial sugar transferase; Region: Bac_transf; pfam02397
749222005506	Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287
749222005507	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
749222005508	active site
749222005509	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
749222005510	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
749222005511	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
749222005512	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
749222005513	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
749222005514	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
749222005515	active site
749222005516	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
749222005517	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
749222005518	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
749222005519	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
749222005520	Walker A/P-loop; other site
749222005521	ATP binding site [chemical binding]; other site
749222005522	Q-loop/lid; other site
749222005523	ABC transporter signature motif; other site
749222005524	Walker B; other site
749222005525	D-loop; other site
749222005526	H-loop/switch region; other site
749222005527	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
749222005528	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
749222005529	putative NAD(P) binding site [chemical binding]; other site
749222005530	active site
749222005531	putative substrate binding site [chemical binding]; other site
749222005532	biotin carboxylase; Validated; Region: PRK08462
749222005533	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
749222005534	ATP-grasp domain; Region: ATP-grasp_4; cl17255
749222005535	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
749222005536	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
749222005537	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
749222005538	carboxyltransferase (CT) interaction site; other site
749222005539	biotinylation site [posttranslational modification]; other site
749222005540	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
749222005541	trimer interface [polypeptide binding]; other site
749222005542	active site
749222005543	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
749222005544	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
749222005545	active site
749222005546	DNA binding site [nucleotide binding]
749222005547	Int/Topo IB signature motif; other site
749222005548	PQQ-like domain; Region: PQQ_2; pfam13360
749222005549	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
749222005550	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
749222005551	Walker A/P-loop; other site
749222005552	ATP binding site [chemical binding]; other site
749222005553	Q-loop/lid; other site
749222005554	ABC transporter signature motif; other site
749222005555	Walker B; other site
749222005556	D-loop; other site
749222005557	H-loop/switch region; other site
749222005558	Smr domain; Region: Smr; pfam01713
749222005559	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
749222005560	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
749222005561	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
749222005562	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
749222005563	hypothetical protein; Provisional; Region: PRK05839
749222005564	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
749222005565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222005566	homodimer interface [polypeptide binding]; other site
749222005567	catalytic residue [active]
749222005568	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
749222005569	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
749222005570	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
749222005571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222005572	homodimer interface [polypeptide binding]; other site
749222005573	catalytic residue [active]
749222005574	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
749222005575	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
749222005576	Protein export membrane protein; Region: SecD_SecF; pfam02355
749222005577	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
749222005578	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
749222005579	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
749222005580	apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291
749222005581	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
749222005582	active site
749222005583	catalytic triad [active]
749222005584	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
749222005585	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
749222005586	acyl-activating enzyme (AAE) consensus motif; other site
749222005587	putative AMP binding site [chemical binding]; other site
749222005588	putative active site [active]
749222005589	putative CoA binding site [chemical binding]; other site
749222005590	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
749222005591	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
749222005592	endonuclease IV; Provisional; Region: PRK01060
749222005593	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
749222005594	AP (apurinic/apyrimidinic) site pocket; other site
749222005595	DNA interaction; other site
749222005596	Metal-binding active site; metal-binding site
749222005597	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
749222005598	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
749222005599	putative dimer interface [polypeptide binding]; other site
749222005600	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
749222005601	putative dimer interface [polypeptide binding]; other site
749222005602	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
749222005603	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
749222005604	active site residue [active]
749222005605	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
749222005606	Competence protein; Region: Competence; pfam03772
749222005607	replicative DNA helicase; Provisional; Region: PRK08506
749222005608	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
749222005609	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
749222005610	Walker A motif; other site
749222005611	ATP binding site [chemical binding]; other site
749222005612	Walker B motif; other site
749222005613	DNA binding loops [nucleotide binding]
749222005614	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
749222005615	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
749222005616	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
749222005617	primosome assembly protein PriA; Validated; Region: PRK05580
749222005618	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
749222005619	ATP binding site [chemical binding]; other site
749222005620	putative Mg++ binding site [ion binding]; other site
749222005621	helicase superfamily c-terminal domain; Region: HELICc; smart00490
749222005622	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
749222005623	putative DNA binding helix; other site
749222005624	DDE domain; Region: DDE_Tnp_IS240; pfam13610
749222005625	Integrase core domain; Region: rve; pfam00665
749222005626	Integrase core domain; Region: rve_3; cl15866
749222005627	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
749222005628	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
749222005629	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
749222005630	substrate binding site; other site
749222005631	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
749222005632	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
749222005633	NAD binding site [chemical binding]; other site
749222005634	homotetramer interface [polypeptide binding]; other site
749222005635	homodimer interface [polypeptide binding]; other site
749222005636	substrate binding site [chemical binding]; other site
749222005637	active site
749222005638	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
749222005639	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
749222005640	PYR/PP interface [polypeptide binding]; other site
749222005641	dimer interface [polypeptide binding]; other site
749222005642	TPP binding site [chemical binding]; other site
749222005643	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
749222005644	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
749222005645	TPP-binding site [chemical binding]; other site
749222005646	Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460
749222005647	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222005648	active site
749222005649	motif I; other site
749222005650	motif II; other site
749222005651	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
749222005652	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
749222005653	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
749222005654	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
749222005655	NAD(P) binding site [chemical binding]; other site
749222005656	active site
749222005657	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
749222005658	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
749222005659	inhibitor-cofactor binding pocket; inhibition site
749222005660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222005661	catalytic residue [active]
749222005662	Predicted membrane protein [Function unknown]; Region: COG2246
749222005663	GtrA-like protein; Region: GtrA; pfam04138
749222005664	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
749222005665	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
749222005666	Ligand binding site; other site
749222005667	Putative Catalytic site; other site
749222005668	DXD motif; other site
749222005669	putative transposase OrfB; Reviewed; Region: PHA02517
749222005670	HTH-like domain; Region: HTH_21; pfam13276
749222005671	Integrase core domain; Region: rve; pfam00665
749222005672	Integrase core domain; Region: rve_3; pfam13683
749222005673	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
749222005674	Transposase; Region: HTH_Tnp_1; cl17663
749222005675	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
749222005676	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
749222005677	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
749222005678	metal binding site [ion binding]; metal-binding site
749222005679	active site
749222005680	I-site; other site
749222005681	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
749222005682	excinuclease ABC subunit B; Provisional; Region: PRK05298
749222005683	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
749222005684	ATP binding site [chemical binding]; other site
749222005685	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
749222005686	nucleotide binding region [chemical binding]; other site
749222005687	ATP-binding site [chemical binding]; other site
749222005688	Ultra-violet resistance protein B; Region: UvrB; pfam12344
749222005689	polyphosphate kinase; Provisional; Region: PRK05443
749222005690	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
749222005691	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
749222005692	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
749222005693	putative domain interface [polypeptide binding]; other site
749222005694	putative active site [active]
749222005695	catalytic site [active]
749222005696	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
749222005697	putative active site [active]
749222005698	catalytic site [active]
749222005699	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
749222005700	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
749222005701	trimer interface [polypeptide binding]; other site
749222005702	putative metal binding site [ion binding]; other site
749222005703	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
749222005704	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
749222005705	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
749222005706	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
749222005707	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
749222005708	FeS/SAM binding site; other site
749222005709	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
749222005710	four helix bundle protein; Region: TIGR02436
749222005711	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
749222005712	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
749222005713	Ligand Binding Site [chemical binding]; other site
749222005714	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
749222005715	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
749222005716	active site
749222005717	dimer interface [polypeptide binding]; other site
749222005718	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
749222005719	Ligand Binding Site [chemical binding]; other site
749222005720	Molecular Tunnel; other site
749222005721	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
749222005722	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
749222005723	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
749222005724	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
749222005725	oligomer interface [polypeptide binding]; other site
749222005726	metal binding site [ion binding]; metal-binding site
749222005727	metal binding site [ion binding]; metal-binding site
749222005728	putative Cl binding site [ion binding]; other site
749222005729	aspartate ring; other site
749222005730	hydrophobic gate; other site
749222005731	periplasmic entrance; other site
749222005732	Protein of unknown function (DUF465); Region: DUF465; cl01070
749222005733	hypothetical protein; Provisional; Region: PRK07101
749222005734	substrate-cofactor binding pocket; other site
749222005735	pyridoxal 5'-phosphate binding site [chemical binding]; other site
749222005736	catalytic residue [active]
749222005737	substrate-cofactor binding pocket; other site
749222005738	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
749222005739	Phosphate transporter family; Region: PHO4; pfam01384
749222005740	Phosphate transporter family; Region: PHO4; cl00396
749222005741	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
749222005742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
749222005743	active site
749222005744	phosphorylation site [posttranslational modification]
749222005745	intermolecular recognition site; other site
749222005746	dimerization interface [polypeptide binding]; other site
749222005747	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
749222005748	DNA binding site [nucleotide binding]
749222005749	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
749222005750	dimer interface [polypeptide binding]; other site
749222005751	phosphorylation site [posttranslational modification]
749222005752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
749222005753	ATP binding site [chemical binding]; other site
749222005754	Mg2+ binding site [ion binding]; other site
749222005755	G-X-G motif; other site
749222005756	Transglycosylase SLT domain; Region: SLT_2; pfam13406
749222005757	murein hydrolase B; Provisional; Region: PRK10760; cl17906
749222005758	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
749222005759	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
749222005760	Tetramer interface [polypeptide binding]; other site
749222005761	active site
749222005762	FMN-binding site [chemical binding]; other site
749222005763	ribonuclease III; Reviewed; Region: rnc; PRK00102
749222005764	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
749222005765	dimerization interface [polypeptide binding]; other site
749222005766	active site
749222005767	metal binding site [ion binding]; metal-binding site
749222005768	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
749222005769	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
749222005770	RNA/DNA hybrid binding site [nucleotide binding]; other site
749222005771	active site
749222005772	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
749222005773	binding surface
749222005774	TPR motif; other site
749222005775	DNA primase; Validated; Region: dnaG; PRK05667
749222005776	CHC2 zinc finger; Region: zf-CHC2; pfam01807
749222005777	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
749222005778	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
749222005779	active site
749222005780	metal binding site [ion binding]; metal-binding site
749222005781	interdomain interaction site; other site
749222005782	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
749222005783	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
749222005784	Ligand Binding Site [chemical binding]; other site
749222005785	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222005786	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
749222005787	dimer interface [polypeptide binding]; other site
749222005788	catalytic triad [active]
749222005789	peroxidatic and resolving cysteines [active]
749222005790	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
749222005791	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
749222005792	4Fe-4S binding domain; Region: Fer4_5; pfam12801
749222005793	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
749222005794	multiple promoter invertase; Provisional; Region: mpi; PRK13413
749222005795	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
749222005796	catalytic residues [active]
749222005797	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
749222005798	trimer interface [polypeptide binding]; other site
749222005799	dimer interface [polypeptide binding]; other site
749222005800	putative active site [active]
749222005801	Protein of unknown function (DUF493); Region: DUF493; pfam04359
749222005802	Paraquat-inducible protein A; Region: PqiA; pfam04403
749222005803	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
749222005804	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
749222005805	active site
749222005806	dimerization interface [polypeptide binding]; other site
749222005807	glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703
749222005808	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
749222005809	active site
749222005810	HIGH motif; other site
749222005811	nucleotide binding site [chemical binding]; other site
749222005812	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
749222005813	KMSKS motif; other site
749222005814	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
749222005815	GatB domain; Region: GatB_Yqey; smart00845
749222005816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
749222005817	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
749222005818	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
749222005819	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324
749222005820	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
749222005821	active site
749222005822	substrate binding site [chemical binding]; other site
749222005823	metal binding site [ion binding]; metal-binding site
749222005824	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
749222005825	peptide chain release factor 1; Validated; Region: prfA; PRK00591
749222005826	This domain is found in peptide chain release factors; Region: PCRF; smart00937
749222005827	RF-1 domain; Region: RF-1; pfam00472
749222005828	Outer membrane efflux protein; Region: OEP; pfam02321
749222005829	Outer membrane efflux protein; Region: OEP; pfam02321
749222005830	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
749222005831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
749222005832	putative substrate translocation pore; other site
749222005833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
749222005834	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
749222005835	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
749222005836	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
749222005837	HlyD family secretion protein; Region: HlyD_3; pfam13437
749222005838	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
749222005839	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
749222005840	hypothetical protein; Provisional; Region: PRK10279
749222005841	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
749222005842	active site
749222005843	nucleophile elbow; other site
749222005844	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
749222005845	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
749222005846	HlyD family secretion protein; Region: HlyD_3; pfam13437
749222005847	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
749222005848	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
749222005849	Walker A/P-loop; other site
749222005850	ATP binding site [chemical binding]; other site
749222005851	Q-loop/lid; other site
749222005852	ABC transporter signature motif; other site
749222005853	Walker B; other site
749222005854	D-loop; other site
749222005855	H-loop/switch region; other site
749222005856	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
749222005857	Walker A/P-loop; other site
749222005858	ATP binding site [chemical binding]; other site
749222005859	Q-loop/lid; other site
749222005860	ABC transporter signature motif; other site
749222005861	Walker B; other site
749222005862	D-loop; other site
749222005863	H-loop/switch region; other site
749222005864	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
749222005865	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
749222005866	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
749222005867	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
749222005868	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
749222005869	active site
749222005870	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
749222005871	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
749222005872	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
749222005873	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
749222005874	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
749222005875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
749222005876	S-adenosylmethionine binding site [chemical binding]; other site
749222005877	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
749222005878	ribosome recycling factor; Reviewed; Region: frr; PRK00083
749222005879	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
749222005880	hinge region; other site
749222005881	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
749222005882	active site
749222005883	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
749222005884	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
749222005885	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
749222005886	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
749222005887	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
749222005888	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
749222005889	active site
749222005890	dimer interface [polypeptide binding]; other site
749222005891	motif 1; other site
749222005892	motif 2; other site
749222005893	motif 3; other site
749222005894	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
749222005895	anticodon binding site; other site
749222005896	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
749222005897	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
749222005898	dimerization interface [polypeptide binding]; other site
749222005899	putative ATP binding site [chemical binding]; other site
749222005900	Domain of unknown function DUF77; Region: DUF77; pfam01910
749222005901	flavoprotein, HI0933 family; Region: TIGR00275
749222005902	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
749222005903	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
749222005904	G1 box; other site
749222005905	putative GEF interaction site [polypeptide binding]; other site
749222005906	GTP/Mg2+ binding site [chemical binding]; other site
749222005907	Switch I region; other site
749222005908	G2 box; other site
749222005909	G3 box; other site
749222005910	Switch II region; other site
749222005911	G4 box; other site
749222005912	G5 box; other site
749222005913	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
749222005914	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
749222005915	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
749222005916	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
749222005917	Zn2+ binding site [ion binding]; other site
749222005918	Mg2+ binding site [ion binding]; other site
749222005919	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
749222005920	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
749222005921	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
749222005922	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
749222005923	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
749222005924	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
749222005925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
749222005926	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
749222005927	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
749222005928	active site
749222005929	putative DNA-binding cleft [nucleotide binding]; other site
749222005930	dimer interface [polypeptide binding]; other site