-- dump date   	20140619_164126
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
323097000001	Transposase domain (DUF772); Region: DUF772; pfam05598
323097000002	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
323097000003	DDE superfamily endonuclease; Region: DDE_4; cl17710
323097000004	Nitrogen regulatory protein P-II; Region: P-II; cl00412
323097000005	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323097000006	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323097000007	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097000008	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
323097000009	putative dimerization interface [polypeptide binding]; other site
323097000010	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
323097000011	metal binding site [ion binding]; metal-binding site
323097000012	active site
323097000013	phosphoribulokinase; Provisional; Region: PRK15453
323097000014	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
323097000015	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
323097000016	intersubunit interface [polypeptide binding]; other site
323097000017	active site
323097000018	zinc binding site [ion binding]; other site
323097000019	Na+ binding site [ion binding]; other site
323097000020	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
323097000021	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
323097000022	homodimer interface [polypeptide binding]; other site
323097000023	active site
323097000024	heterodimer interface [polypeptide binding]; other site
323097000025	catalytic residue [active]
323097000026	metal binding site [ion binding]; metal-binding site
323097000027	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
323097000028	multimerization interface [polypeptide binding]; other site
323097000029	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
323097000030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097000031	Walker A motif; other site
323097000032	ATP binding site [chemical binding]; other site
323097000033	Walker B motif; other site
323097000034	arginine finger; other site
323097000035	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
323097000036	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
323097000037	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
323097000038	HipA-like N-terminal domain; Region: HipA_N; pfam07805
323097000039	HipA-like C-terminal domain; Region: HipA_C; pfam07804
323097000040	Transposase, Mutator family; Region: Transposase_mut; pfam00872
323097000041	MULE transposase domain; Region: MULE; pfam10551
323097000042	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
323097000043	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
323097000044	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323097000045	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
323097000046	Coenzyme A binding pocket [chemical binding]; other site
323097000047	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
323097000048	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
323097000049	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
323097000050	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323097000051	Ligand Binding Site [chemical binding]; other site
323097000052	PRC-barrel domain; Region: PRC; pfam05239
323097000053	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
323097000054	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
323097000055	dimerization interface [polypeptide binding]; other site
323097000056	DPS ferroxidase diiron center [ion binding]; other site
323097000057	ion pore; other site
323097000058	aconitate hydratase; Validated; Region: PRK09277
323097000059	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
323097000060	substrate binding site [chemical binding]; other site
323097000061	ligand binding site [chemical binding]; other site
323097000062	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
323097000063	substrate binding site [chemical binding]; other site
323097000064	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097000065	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
323097000066	active site
323097000067	metal binding site [ion binding]; metal-binding site
323097000068	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
323097000069	Moco binding site; other site
323097000070	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
323097000071	metal coordination site [ion binding]; other site
323097000072	dimerization interface [polypeptide binding]; other site
323097000073	Homeodomain-like domain; Region: HTH_23; pfam13384
323097000074	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000075	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097000076	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097000077	Transposase domain (DUF772); Region: DUF772; pfam05598
323097000078	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
323097000079	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
323097000080	Helix-turn-helix domain; Region: HTH_28; pfam13518
323097000081	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000082	Homeodomain-like domain; Region: HTH_32; pfam13565
323097000083	Integrase core domain; Region: rve; pfam00665
323097000084	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097000085	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097000086	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323097000087	Protein of unknown function DUF72; Region: DUF72; pfam01904
323097000088	PRC-barrel domain; Region: PRC; pfam05239
323097000089	Phospholipid methyltransferase; Region: PEMT; cl17370
323097000090	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
323097000091	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
323097000092	malonyl-CoA binding site [chemical binding]; other site
323097000093	dimer interface [polypeptide binding]; other site
323097000094	active site
323097000095	product binding site; other site
323097000096	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
323097000097	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
323097000098	Cation efflux family; Region: Cation_efflux; pfam01545
323097000099	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
323097000100	Helix-turn-helix domain; Region: HTH_38; pfam13936
323097000101	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000102	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000103	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097000104	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323097000105	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
323097000106	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
323097000107	putative active site [active]
323097000108	putative NTP binding site [chemical binding]; other site
323097000109	putative nucleic acid binding site [nucleotide binding]; other site
323097000110	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
323097000111	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097000112	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000113	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000114	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097000115	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
323097000116	Homeodomain-like domain; Region: HTH_23; pfam13384
323097000117	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000118	Homeodomain-like domain; Region: HTH_32; pfam13565
323097000119	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097000120	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097000121	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097000122	Low affinity iron permease; Region: Iron_permease; pfam04120
323097000123	PRC-barrel domain; Region: PRC; pfam05239
323097000124	Helix-turn-helix domain; Region: HTH_28; pfam13518
323097000125	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000126	Homeodomain-like domain; Region: HTH_32; pfam13565
323097000127	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097000128	Homeodomain-like domain; Region: HTH_23; pfam13384
323097000129	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000130	Homeodomain-like domain; Region: HTH_32; pfam13565
323097000131	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097000132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097000133	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000134	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000135	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097000136	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
323097000137	Helix-turn-helix domain; Region: HTH_28; pfam13518
323097000138	putative transposase OrfB; Reviewed; Region: PHA02517
323097000139	Homeodomain-like domain; Region: HTH_32; pfam13565
323097000140	Integrase core domain; Region: rve; pfam00665
323097000141	Integrase core domain; Region: rve_3; pfam13683
323097000142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000143	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000144	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097000145	Transposase; Region: HTH_Tnp_1; pfam01527
323097000146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323097000147	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
323097000148	Domain of unknown function DUF20; Region: UPF0118; pfam01594
323097000149	GAF domain; Region: GAF; pfam01590
323097000150	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
323097000151	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
323097000152	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
323097000153	Transposase domain (DUF772); Region: DUF772; pfam05598
323097000154	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
323097000155	DDE superfamily endonuclease; Region: DDE_4; cl17710
323097000156	PRC-barrel domain; Region: PRC; pfam05239
323097000157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
323097000158	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323097000159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097000160	active site
323097000161	phosphorylation site [posttranslational modification]
323097000162	intermolecular recognition site; other site
323097000163	dimerization interface [polypeptide binding]; other site
323097000164	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
323097000165	dinuclear metal binding motif [ion binding]; other site
323097000166	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
323097000167	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000168	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000169	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097000170	large terminase protein; Provisional; Region: 17; PHA02533
323097000171	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
323097000172	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000173	Homeodomain-like domain; Region: HTH_23; cl17451
323097000174	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
323097000175	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
323097000176	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
323097000177	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
323097000178	short chain dehydrogenase; Provisional; Region: PRK07109
323097000179	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
323097000180	putative NAD(P) binding site [chemical binding]; other site
323097000181	active site
323097000182	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
323097000183	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
323097000184	Subunit I/III interface [polypeptide binding]; other site
323097000185	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
323097000186	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
323097000187	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
323097000188	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
323097000189	Cytochrome c; Region: Cytochrom_C; pfam00034
323097000190	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
323097000191	Cu(I) binding site [ion binding]; other site
323097000192	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
323097000193	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
323097000194	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
323097000195	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
323097000196	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097000197	molybdopterin cofactor binding site; other site
323097000198	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
323097000199	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
323097000200	4Fe-4S binding domain; Region: Fer4; cl02805
323097000201	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
323097000202	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
323097000203	heme-binding residues [chemical binding]; other site
323097000204	Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100
323097000205	thiamine pyrophosphate protein; Provisional; Region: PRK08273
323097000206	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
323097000207	PYR/PP interface [polypeptide binding]; other site
323097000208	dimer interface [polypeptide binding]; other site
323097000209	tetramer interface [polypeptide binding]; other site
323097000210	TPP binding site [chemical binding]; other site
323097000211	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
323097000212	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
323097000213	TPP-binding site [chemical binding]; other site
323097000214	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
323097000215	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
323097000216	putative active site pocket [active]
323097000217	putative metal binding site [ion binding]; other site
323097000218	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
323097000219	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
323097000220	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097000221	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
323097000222	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
323097000223	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
323097000224	Protein of unknown function DUF72; Region: DUF72; pfam01904
323097000225	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
323097000226	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
323097000227	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
323097000228	Conjugal transfer protein TraD; Region: TraD; cl05753
323097000229	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
323097000230	MASE1; Region: MASE1; cl17823
323097000231	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097000232	HWE histidine kinase; Region: HWE_HK; smart00911
323097000233	Transposase; Region: HTH_Tnp_1; cl17663
323097000234	putative transposase OrfB; Reviewed; Region: PHA02517
323097000235	HTH-like domain; Region: HTH_21; pfam13276
323097000236	Integrase core domain; Region: rve; pfam00665
323097000237	Integrase core domain; Region: rve_3; pfam13683
323097000238	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
323097000239	DEAD-like helicases superfamily; Region: DEXDc; smart00487
323097000240	ATP binding site [chemical binding]; other site
323097000241	putative Mg++ binding site [ion binding]; other site
323097000242	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
323097000243	nucleotide binding region [chemical binding]; other site
323097000244	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323097000245	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097000246	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097000247	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323097000248	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323097000249	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097000250	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
323097000251	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
323097000252	DXD motif; other site
323097000253	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
323097000254	Homeodomain-like domain; Region: HTH_23; pfam13384
323097000255	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000256	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
323097000257	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
323097000258	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000259	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
323097000260	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
323097000261	Homeodomain-like domain; Region: HTH_23; pfam13384
323097000262	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000263	Homeodomain-like domain; Region: HTH_32; pfam13565
323097000264	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097000265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097000266	Helix-turn-helix domain; Region: HTH_28; pfam13518
323097000267	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000268	Homeodomain-like domain; Region: HTH_32; pfam13565
323097000269	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097000270	calcium/proton exchanger (cax); Region: cax; TIGR00378
323097000271	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
323097000272	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
323097000273	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
323097000274	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323097000275	Cytochrome c; Region: Cytochrom_C; cl11414
323097000276	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323097000277	Cytochrome c; Region: Cytochrom_C; pfam00034
323097000278	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000279	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000280	PRC-barrel domain; Region: PRC; pfam05239
323097000281	Transposase domain (DUF772); Region: DUF772; pfam05598
323097000282	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
323097000283	DDE superfamily endonuclease; Region: DDE_4; cl17710
323097000284	Homeodomain-like domain; Region: HTH_23; pfam13384
323097000285	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000286	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097000287	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097000288	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097000289	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097000290	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323097000291	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
323097000292	large terminase protein; Provisional; Region: 17; PHA02533
323097000293	Transposase domain (DUF772); Region: DUF772; pfam05598
323097000294	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
323097000295	DDE superfamily endonuclease; Region: DDE_4; cl17710
323097000296	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
323097000297	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
323097000298	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323097000299	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097000300	P-loop; other site
323097000301	Magnesium ion binding site [ion binding]; other site
323097000302	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
323097000303	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
323097000304	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
323097000305	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
323097000306	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
323097000307	dimer interface [polypeptide binding]; other site
323097000308	ssDNA binding site [nucleotide binding]; other site
323097000309	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323097000310	replication initiation protein RepC; Provisional; Region: PRK13824
323097000311	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097000312	putative DNA binding site [nucleotide binding]; other site
323097000313	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
323097000314	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
323097000315	ParB-like nuclease domain; Region: ParB; smart00470
323097000316	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
323097000317	MerR family regulatory protein; Region: MerR; pfam00376
323097000318	DNA binding residues [nucleotide binding]
323097000319	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097000320	P-loop; other site
323097000321	Magnesium ion binding site [ion binding]; other site
323097000322	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097000323	Magnesium ion binding site [ion binding]; other site
323097000324	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
323097000325	oligomeric interface; other site
323097000326	putative active site [active]
323097000327	homodimer interface [polypeptide binding]; other site
323097000328	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
323097000329	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097000330	AAA domain; Region: AAA_22; pfam13401
323097000331	Walker A motif; other site
323097000332	ATP binding site [chemical binding]; other site
323097000333	Walker B motif; other site
323097000334	arginine finger; other site
323097000335	Helix-turn-helix domain; Region: HTH_17; pfam12728
323097000336	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000337	Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039
323097000338	Integrase core domain; Region: rve; pfam00665
323097000339	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
323097000340	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
323097000341	HTH DNA binding domain; Region: HTH_13; pfam11972
323097000342	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
323097000343	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
323097000344	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000346	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097000347	Transposase, Mutator family; Region: Transposase_mut; pfam00872
323097000348	MULE transposase domain; Region: MULE; pfam10551
323097000349	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097000350	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
323097000351	heme-binding site [chemical binding]; other site
323097000352	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
323097000353	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
323097000354	phosphate binding motif [ion binding]; other site
323097000355	beta-alpha-beta structure motif; other site
323097000356	NAD binding pocket [chemical binding]; other site
323097000357	conjugal transfer protein TraH; Provisional; Region: PRK13843
323097000358	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323097000359	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
323097000360	putative dimer interface [polypeptide binding]; other site
323097000361	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323097000362	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
323097000363	putative dimer interface [polypeptide binding]; other site
323097000364	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
323097000365	putative active site [active]
323097000366	Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834
323097000367	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000368	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000369	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097000370	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009
323097000371	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323097000372	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323097000373	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323097000374	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323097000375	Nitrogen regulatory protein P-II; Region: P-II; cl00412
323097000376	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323097000377	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009
323097000378	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323097000379	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323097000380	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323097000381	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323097000382	Nitrogen regulatory protein P-II; Region: P-II; cl00412
323097000383	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323097000384	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323097000385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097000386	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
323097000387	putative dimerization interface [polypeptide binding]; other site
323097000388	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
323097000389	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
323097000390	dimer interface [polypeptide binding]; other site
323097000391	catalytic residue [active]
323097000392	metal binding site [ion binding]; metal-binding site
323097000393	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
323097000394	multimerization interface [polypeptide binding]; other site
323097000395	Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288
323097000396	Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936
323097000397	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
323097000398	Hexamer/Pentamer interface [polypeptide binding]; other site
323097000399	central pore; other site
323097000400	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
323097000401	Hexamer/Pentamer interface [polypeptide binding]; other site
323097000402	central pore; other site
323097000403	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
323097000404	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
323097000405	Hexamer interface [polypeptide binding]; other site
323097000406	Hexagonal pore residue; other site
323097000407	Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058
323097000408	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
323097000409	Hexamer interface [polypeptide binding]; other site
323097000410	Hexagonal pore residue; other site
323097000411	Hexagonal pore; other site
323097000412	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
323097000413	aromatic arch; other site
323097000414	DCoH dimer interaction site [polypeptide binding]; other site
323097000415	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
323097000416	DCoH tetramer interaction site [polypeptide binding]; other site
323097000417	substrate binding site [chemical binding]; other site
323097000418	ParA-like protein; Provisional; Region: PHA02518
323097000419	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097000420	P-loop; other site
323097000421	Magnesium ion binding site [ion binding]; other site
323097000422	MoxR-like ATPases [General function prediction only]; Region: COG0714
323097000423	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097000424	Walker A motif; other site
323097000425	ATP binding site [chemical binding]; other site
323097000426	Walker B motif; other site
323097000427	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
323097000428	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
323097000429	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
323097000430	putative hexamer interface [polypeptide binding]; other site
323097000431	putative hexagonal pore; other site
323097000432	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
323097000433	putative hexamer interface [polypeptide binding]; other site
323097000434	putative hexagonal pore; other site
323097000435	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097000436	HTH-like domain; Region: HTH_21; pfam13276
323097000437	Transposase; Region: HTH_Tnp_1; cl17663
323097000438	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
323097000439	S-adenosylmethionine binding site [chemical binding]; other site
323097000440	YtkA-like; Region: YtkA; pfam13115
323097000441	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
323097000442	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097000443	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
323097000444	Cytochrome c; Region: Cytochrom_C; cl11414
323097000445	RNA polymerase sigma factor; Provisional; Region: PRK12539
323097000446	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323097000447	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
323097000448	DNA binding residues [nucleotide binding]
323097000449	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
323097000450	Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751
323097000451	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
323097000452	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323097000453	Soluble P-type ATPase [General function prediction only]; Region: COG4087
323097000454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097000455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
323097000456	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
323097000457	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323097000458	putative phosphoketolase; Provisional; Region: PRK05261
323097000459	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
323097000460	TPP-binding site; other site
323097000461	XFP C-terminal domain; Region: XFP_C; pfam09363
323097000462	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
323097000463	active site
323097000464	Eukaryotic phosphomannomutase; Region: PMM; cl17107
323097000465	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
323097000466	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
323097000467	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097000468	motif II; other site
323097000469	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
323097000470	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
323097000471	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
323097000472	glucokinase, proteobacterial type; Region: glk; TIGR00749
323097000473	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
323097000474	nucleotide binding site [chemical binding]; other site
323097000475	Acetokinase family; Region: Acetate_kinase; cl17229
323097000476	propionate/acetate kinase; Provisional; Region: PRK12379
323097000477	FOG: CBS domain [General function prediction only]; Region: COG0517
323097000478	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
323097000479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323097000480	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
323097000481	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323097000482	ligand binding site [chemical binding]; other site
323097000483	flexible hinge region; other site
323097000484	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
323097000485	putative switch regulator; other site
323097000486	non-specific DNA interactions [nucleotide binding]; other site
323097000487	DNA binding site [nucleotide binding]
323097000488	sequence specific DNA binding site [nucleotide binding]; other site
323097000489	putative cAMP binding site [chemical binding]; other site
323097000490	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
323097000491	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
323097000492	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
323097000493	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323097000494	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
323097000495	Soluble P-type ATPase [General function prediction only]; Region: COG4087
323097000496	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
323097000497	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
323097000498	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
323097000499	S-adenosylmethionine binding site [chemical binding]; other site
323097000500	YHS domain; Region: YHS; pfam04945
323097000501	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
323097000502	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323097000503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097000504	motif II; other site
323097000505	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
323097000506	putative homodimer interface [polypeptide binding]; other site
323097000507	putative homotetramer interface [polypeptide binding]; other site
323097000508	putative allosteric switch controlling residues; other site
323097000509	putative metal binding site [ion binding]; other site
323097000510	putative homodimer-homodimer interface [polypeptide binding]; other site
323097000511	Outer membrane efflux protein; Region: OEP; pfam02321
323097000512	Outer membrane efflux protein; Region: OEP; pfam02321
323097000513	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
323097000514	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
323097000515	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
323097000516	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
323097000517	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
323097000518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
323097000519	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323097000520	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097000521	catalytic residues [active]
323097000522	Recombinase; Region: Recombinase; pfam07508
323097000523	Helix-turn-helix domain; Region: HTH_17; pfam12728
323097000524	Autoinducer binding domain; Region: Autoind_bind; pfam03472
323097000525	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323097000526	DNA binding residues [nucleotide binding]
323097000527	dimerization interface [polypeptide binding]; other site
323097000528	Copper resistance protein D; Region: CopD; cl00563
323097000529	CopC domain; Region: CopC; pfam04234
323097000530	Protein of unknown function, DUF; Region: DUF411; cl01142
323097000531	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
323097000532	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
323097000533	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
323097000534	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097000535	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
323097000536	RNA polymerase sigma factor; Provisional; Region: PRK12539
323097000537	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323097000538	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323097000539	DNA binding residues [nucleotide binding]
323097000540	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
323097000541	Phospholipid methyltransferase; Region: PEMT; cl17370
323097000542	OpgC protein; Region: OpgC_C; pfam10129
323097000543	Acyltransferase family; Region: Acyl_transf_3; pfam01757
323097000544	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
323097000545	metal-binding site [ion binding]
323097000546	MerT mercuric transport protein; Region: MerT; cl03578
323097000547	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
323097000548	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
323097000549	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
323097000550	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
323097000551	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
323097000552	DNA binding residues [nucleotide binding]
323097000553	dimer interface [polypeptide binding]; other site
323097000554	metal binding site [ion binding]; metal-binding site
323097000555	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
323097000556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097000557	putative substrate translocation pore; other site
323097000558	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
323097000559	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
323097000560	metal-binding site [ion binding]
323097000561	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323097000562	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097000563	motif II; other site
323097000564	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
323097000565	metal-binding site [ion binding]
323097000566	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097000567	dimerization interface [polypeptide binding]; other site
323097000568	putative DNA binding site [nucleotide binding]; other site
323097000569	putative Zn2+ binding site [ion binding]; other site
323097000570	Small subunit of Arsenite oxidase (ArOX) family, Rieske domain; ArOX is a molybdenum/iron protein involved in the detoxification of arsenic, oxidizing it to arsenate. It consists of two subunits, a large subunit similar to members of the DMSO reductase...; Region: Rieske_ArOX_small; cd03476
323097000571	[2Fe-2S] cluster binding site [ion binding]; other site
323097000572	subunit interaction site [polypeptide binding]; other site
323097000573	Arsenite oxidase (Arsenite-Ox) oxidizes arsenite to the less toxic arsenate; it transfers the electrons obtained from the oxidation of arsenite towards the soluble periplasmic electron carriers cytochrome c and/or amicyanin.  Arsenite oxidase is a...; Region: MopB_Arsenite-Ox; cd02756
323097000574	arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693
323097000575	[3Fe-4S] binding site [ion binding]; other site
323097000576	molybdopterin cofactor binding site [chemical binding]; other site
323097000577	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
323097000578	molybdopterin cofactor binding site; other site
323097000579	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
323097000580	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
323097000581	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
323097000582	ArsC family; Region: ArsC; pfam03960
323097000583	catalytic residues [active]
323097000584	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
323097000585	amphipathic channel; other site
323097000586	Asn-Pro-Ala signature motifs; other site
323097000587	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097000588	putative DNA binding site [nucleotide binding]; other site
323097000589	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
323097000590	Low molecular weight phosphatase family; Region: LMWPc; cd00115
323097000591	active site
323097000592	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097000593	dimerization interface [polypeptide binding]; other site
323097000594	putative DNA binding site [nucleotide binding]; other site
323097000595	putative Zn2+ binding site [ion binding]; other site
323097000596	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
323097000597	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
323097000598	Major Facilitator Superfamily; Region: MFS_1; pfam07690
323097000599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097000600	putative substrate translocation pore; other site
323097000601	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
323097000602	Autoinducer binding domain; Region: Autoind_bind; pfam03472
323097000603	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323097000604	DNA binding residues [nucleotide binding]
323097000605	dimerization interface [polypeptide binding]; other site
323097000606	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
323097000607	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323097000608	Walker A motif; other site
323097000609	ATP binding site [chemical binding]; other site
323097000610	Walker B motif; other site
323097000611	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
323097000612	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
323097000613	Walker A motif; other site
323097000614	hexamer interface [polypeptide binding]; other site
323097000615	ATP binding site [chemical binding]; other site
323097000616	Walker B motif; other site
323097000617	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
323097000618	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
323097000619	VirB7 interaction site; other site
323097000620	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
323097000621	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
323097000622	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
323097000623	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
323097000624	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
323097000625	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
323097000626	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323097000627	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
323097000628	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323097000629	catalytic residue [active]
323097000630	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
323097000631	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
323097000632	dimer interface [polypeptide binding]; other site
323097000633	ssDNA binding site [nucleotide binding]; other site
323097000634	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323097000635	hypothetical protein; Provisional; Region: PRK06518
323097000636	Staphylococcal nuclease homologues; Region: SNc; smart00318
323097000637	Catalytic site; other site
323097000638	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
323097000639	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
323097000640	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097000641	DEAD-like helicases superfamily; Region: DEXDc; smart00487
323097000642	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097000643	ATP binding site [chemical binding]; other site
323097000644	putative Mg++ binding site [ion binding]; other site
323097000645	helicase superfamily c-terminal domain; Region: HELICc; smart00490
323097000646	nucleotide binding region [chemical binding]; other site
323097000647	ATP-binding site [chemical binding]; other site
323097000648	Autoinducer synthetase; Region: Autoind_synth; cl17404
323097000649	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
323097000650	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
323097000651	active site
323097000652	metal binding site [ion binding]; metal-binding site
323097000653	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
323097000654	Protein of unknown function (DUF1419); Region: DUF1419; pfam07215
323097000655	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
323097000656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097000657	S-adenosylmethionine binding site [chemical binding]; other site
323097000658	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
323097000659	DEAD-like helicases superfamily; Region: DEXDc; smart00487
323097000660	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
323097000661	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
323097000662	nucleotide binding region [chemical binding]; other site
323097000663	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
323097000664	ATP-binding site [chemical binding]; other site
323097000665	plasmid partitioning protein; Provisional; Region: PRK13832
323097000666	ParB-like nuclease domain; Region: ParB; smart00470
323097000667	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
323097000668	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
323097000669	Protein of unknown function (DUF736); Region: DUF736; pfam05284
323097000670	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
323097000671	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
323097000672	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
323097000673	Domain of unknown function (DUF955); Region: DUF955; cl01076
323097000674	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
323097000675	active site
323097000676	NTP binding site [chemical binding]; other site
323097000677	metal binding triad [ion binding]; metal-binding site
323097000678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097000679	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
323097000680	Walker A motif; other site
323097000681	ATP binding site [chemical binding]; other site
323097000682	Walker B motif; other site
323097000683	arginine finger; other site
323097000684	Methyltransferase domain; Region: Methyltransf_26; pfam13659
323097000685	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
323097000686	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097000687	ATP binding site [chemical binding]; other site
323097000688	putative Mg++ binding site [ion binding]; other site
323097000689	T5orf172 domain; Region: T5orf172; pfam10544
323097000690	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097000691	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
323097000692	Walker A motif; other site
323097000693	ATP binding site [chemical binding]; other site
323097000694	Walker B motif; other site
323097000695	5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736
323097000696	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
323097000697	HTH DNA binding domain; Region: HTH_13; pfam11972
323097000698	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000699	Integrase core domain; Region: rve; pfam00665
323097000700	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
323097000701	Bacterial TniB protein; Region: TniB; pfam05621
323097000702	TniQ; Region: TniQ; pfam06527
323097000703	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
323097000704	Protein of unknown function (DUF1403); Region: DUF1403; pfam07183
323097000705	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
323097000706	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097000707	active site
323097000708	Int/Topo IB signature motif; other site
323097000709	DNA binding site [nucleotide binding]
323097000710	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
323097000711	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
323097000712	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
323097000713	DNA binding site [nucleotide binding]
323097000714	dimer interface [polypeptide binding]; other site
323097000715	Int/Topo IB signature motif; other site
323097000716	active site
323097000717	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
323097000718	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097000719	P-loop; other site
323097000720	Magnesium ion binding site [ion binding]; other site
323097000721	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097000722	Magnesium ion binding site [ion binding]; other site
323097000723	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
323097000724	ParB-like nuclease domain; Region: ParBc; pfam02195
323097000725	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
323097000726	catalytic residue [active]
323097000727	replication initiation protein RepC; Provisional; Region: PRK13824
323097000728	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097000729	putative DNA binding site [nucleotide binding]; other site
323097000730	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
323097000731	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
323097000732	dimer interface [polypeptide binding]; other site
323097000733	ssDNA binding site [nucleotide binding]; other site
323097000734	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323097000735	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
323097000736	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
323097000737	AAA domain; Region: AAA_17; pfam13207
323097000738	Walker A/P-loop; other site
323097000739	ATP binding site [chemical binding]; other site
323097000740	replication initiation protein RepC; Provisional; Region: PRK13824
323097000741	Replication protein C N-terminal domain; Region: RP-C; pfam03428
323097000742	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
323097000743	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323097000744	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097000745	P-loop; other site
323097000746	Magnesium ion binding site [ion binding]; other site
323097000747	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
323097000748	Outer membrane efflux protein; Region: OEP; pfam02321
323097000749	Outer membrane efflux protein; Region: OEP; pfam02321
323097000750	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097000751	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097000752	Nitrogen regulatory protein P-II; Region: P-II; cl00412
323097000753	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323097000754	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
323097000755	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
323097000756	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
323097000757	metal-binding site [ion binding]
323097000758	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323097000759	Soluble P-type ATPase [General function prediction only]; Region: COG4087
323097000760	PilZ domain; Region: PilZ; pfam07238
323097000761	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
323097000762	Dtr system oriT relaxase; Provisional; Region: PRK13826
323097000763	MobA/MobL family; Region: MobA_MobL; pfam03389
323097000764	AAA domain; Region: AAA_30; pfam13604
323097000765	Family description; Region: UvrD_C_2; pfam13538
323097000766	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
323097000767	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
323097000768	conjugal transfer protein TraB; Provisional; Region: PRK13825
323097000769	active site
323097000770	catalytic triad [active]
323097000771	conjugal transfer protein TraH; Provisional; Region: PRK13843
323097000772	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323097000773	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
323097000774	putative dimer interface [polypeptide binding]; other site
323097000775	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323097000776	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
323097000777	putative dimer interface [polypeptide binding]; other site
323097000778	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
323097000779	putative active site [active]
323097000780	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000781	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000782	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097000783	Prokaryotic Transcriptional repressor TraM; Region: Prok-TraM; pfam09228
323097000784	transcriptional regulator TraR; Provisional; Region: PRK13870
323097000785	Autoinducer binding domain; Region: Autoind_bind; pfam03472
323097000786	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323097000787	DNA binding residues [nucleotide binding]
323097000788	dimerization interface [polypeptide binding]; other site
323097000789	conjugal transfer protein TrbI; Provisional; Region: PRK13831
323097000790	conjugal transfer protein TrbH; Provisional; Region: PRK13835
323097000791	Conjugal transfer protein TrbH; Region: TrbH; pfam07283
323097000792	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
323097000793	VirB7 interaction site; other site
323097000794	conjugal transfer protein TrbF; Provisional; Region: PRK13836
323097000795	conjugal transfer protein TrbL; Provisional; Region: PRK13841
323097000796	entry exclusion protein TrbK, Ti-type; Region: TrbK_Ti; TIGR04361
323097000797	conjugal transfer protein TrbJ; Provisional; Region: PRK13842
323097000798	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
323097000799	conjugal transfer protein TrbE; Provisional; Region: PRK13830
323097000800	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
323097000801	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097000802	Walker A/P-loop; other site
323097000803	ATP binding site [chemical binding]; other site
323097000804	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097000805	Walker B; other site
323097000806	D-loop; other site
323097000807	H-loop/switch region; other site
323097000808	conjugal transfer protein TrbD; Provisional; Region: PRK13823
323097000809	conjugal transfer protein TrbC; Provisional; Region: PRK13871
323097000810	conjugal transfer protein TrbB; Provisional; Region: PRK13833
323097000811	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
323097000812	ATP binding site [chemical binding]; other site
323097000813	Walker A motif; other site
323097000814	hexamer interface [polypeptide binding]; other site
323097000815	Walker B motif; other site
323097000816	putative autoinducer synthesis protein; Provisional; Region: PRK13834
323097000817	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
323097000818	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
323097000819	DNA binding residues [nucleotide binding]
323097000820	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097000821	P-loop; other site
323097000822	Magnesium ion binding site [ion binding]; other site
323097000823	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097000824	Magnesium ion binding site [ion binding]; other site
323097000825	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
323097000826	ParB-like nuclease domain; Region: ParBc; pfam02195
323097000827	replication initiation protein RepC; Provisional; Region: PRK13824
323097000828	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097000829	putative DNA binding site [nucleotide binding]; other site
323097000830	putative Zn2+ binding site [ion binding]; other site
323097000831	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
323097000832	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
323097000833	oligomeric interface; other site
323097000834	putative active site [active]
323097000835	homodimer interface [polypeptide binding]; other site
323097000836	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
323097000837	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
323097000838	DNA binding site [nucleotide binding]
323097000839	dimer interface [polypeptide binding]; other site
323097000840	Int/Topo IB signature motif; other site
323097000841	active site
323097000842	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
323097000843	putative active site [active]
323097000844	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
323097000845	Integrase core domain; Region: rve; pfam00665
323097000846	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
323097000847	Bacterial TniB protein; Region: TniB; pfam05621
323097000848	AAA domain; Region: AAA_22; pfam13401
323097000849	TniQ; Region: TniQ; pfam06527
323097000850	Protein of unknown function (DUF1403); Region: DUF1403; pfam07183
323097000851	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
323097000852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
323097000853	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
323097000854	Coenzyme A binding pocket [chemical binding]; other site
323097000855	CHASE3 domain; Region: CHASE3; cl05000
323097000856	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
323097000857	dimerization interface [polypeptide binding]; other site
323097000858	GAF domain; Region: GAF; cl17456
323097000859	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323097000860	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323097000861	metal binding site [ion binding]; metal-binding site
323097000862	active site
323097000863	I-site; other site
323097000864	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
323097000865	Domain of unknown function DUF21; Region: DUF21; pfam01595
323097000866	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
323097000867	Transporter associated domain; Region: CorC_HlyC; smart01091
323097000868	Transposase IS200 like; Region: Y1_Tnp; pfam01797
323097000869	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
323097000870	Homeodomain-like domain; Region: HTH_23; pfam13384
323097000871	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000872	Homeodomain-like domain; Region: HTH_32; pfam13565
323097000873	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097000874	Homeodomain-like domain; Region: HTH_23; pfam13384
323097000875	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000876	Homeodomain-like domain; Region: HTH_32; pfam13565
323097000877	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097000878	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097000879	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
323097000880	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
323097000881	putative di-iron ligands [ion binding]; other site
323097000882	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
323097000883	CheB methylesterase; Region: CheB_methylest; pfam01339
323097000884	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
323097000885	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
323097000886	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
323097000887	PAS domain; Region: PAS_10; pfam13596
323097000888	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097000889	HWE histidine kinase; Region: HWE_HK; pfam07536
323097000890	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097000891	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323097000892	catalytic residues [active]
323097000893	catalytic nucleophile [active]
323097000894	Recombinase; Region: Recombinase; pfam07508
323097000895	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323097000896	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
323097000897	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
323097000898	Sulfate transporter family; Region: Sulfate_transp; pfam00916
323097000899	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
323097000900	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000902	PAS domain; Region: PAS_10; pfam13596
323097000903	PAS fold; Region: PAS_4; pfam08448
323097000904	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097000905	HWE histidine kinase; Region: HWE_HK; smart00911
323097000906	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
323097000907	active site residue [active]
323097000908	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
323097000909	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
323097000910	Sulphur transport; Region: Sulf_transp; pfam04143
323097000911	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
323097000912	Predicted transporter component [General function prediction only]; Region: COG2391
323097000913	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097000914	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097000915	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097000916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
323097000917	YHS domain; Region: YHS; pfam04945
323097000918	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
323097000919	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323097000920	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097000921	motif II; other site
323097000922	Outer membrane efflux protein; Region: OEP; pfam02321
323097000923	Outer membrane efflux protein; Region: OEP; pfam02321
323097000924	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
323097000925	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
323097000926	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
323097000927	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
323097000928	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
323097000929	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
323097000930	Homeodomain-like domain; Region: HTH_23; pfam13384
323097000931	Winged helix-turn helix; Region: HTH_29; pfam13551
323097000932	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
323097000933	putative regulator PrlF; Provisional; Region: PRK09974
323097000934	Methyltransferase domain; Region: Methyltransf_31; pfam13847
323097000935	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097000936	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
323097000937	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323097000938	catalytic residues [active]
323097000939	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
323097000940	RNA polymerase sigma factor; Provisional; Region: PRK12512
323097000941	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323097000942	DNA binding residues [nucleotide binding]
323097000943	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
323097000944	hypothetical protein; Provisional; Region: PRK05409
323097000945	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
323097000946	Predicted membrane protein [Function unknown]; Region: COG2259
323097000947	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
323097000948	Toprim-like; Region: Toprim_2; pfam13155
323097000949	active site
323097000950	metal binding site [ion binding]; metal-binding site
323097000951	Protein of unknown function (DUF1419); Region: DUF1419; pfam07215
323097000952	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
323097000953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097000954	S-adenosylmethionine binding site [chemical binding]; other site
323097000955	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
323097000956	DEAD-like helicases superfamily; Region: DEXDc; smart00487
323097000957	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
323097000958	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
323097000959	helicase superfamily c-terminal domain; Region: HELICc; smart00490
323097000960	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
323097000961	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
323097000962	Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869
323097000963	peptide binding site [polypeptide binding]; other site
323097000964	plasmid partitioning protein; Provisional; Region: PRK13832
323097000965	ParB-like nuclease domain; Region: ParB; smart00470
323097000966	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
323097000967	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
323097000968	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097000969	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
323097000970	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
323097000971	dimer interface [polypeptide binding]; other site
323097000972	ssDNA binding site [nucleotide binding]; other site
323097000973	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323097000974	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
323097000975	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
323097000976	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
323097000977	Catalytic site; other site
323097000978	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
323097000979	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323097000980	Walker A motif; other site
323097000981	ATP binding site [chemical binding]; other site
323097000982	Walker B motif; other site
323097000983	Conjugal transfer protein TraD; Region: TraD; cl05753
323097000984	conjugal transfer protein TraC; Provisional; Region: PRK13848
323097000985	DnaA N-terminal domain; Region: DnaA_N; pfam11638
323097000986	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
323097000987	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097000988	Walker A motif; other site
323097000989	ATP binding site [chemical binding]; other site
323097000990	Walker B motif; other site
323097000991	arginine finger; other site
323097000992	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
323097000993	DnaA box-binding interface [nucleotide binding]; other site
323097000994	DNA polymerase III subunit beta; Validated; Region: PRK05643
323097000995	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
323097000996	putative DNA binding surface [nucleotide binding]; other site
323097000997	dimer interface [polypeptide binding]; other site
323097000998	beta-clamp/clamp loader binding surface; other site
323097000999	beta-clamp/translesion DNA polymerase binding surface; other site
323097001000	recombination protein F; Reviewed; Region: recF; PRK00064
323097001001	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097001002	Walker A/P-loop; other site
323097001003	ATP binding site [chemical binding]; other site
323097001004	Q-loop/lid; other site
323097001005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097001006	ABC transporter signature motif; other site
323097001007	Walker B; other site
323097001008	D-loop; other site
323097001009	H-loop/switch region; other site
323097001010	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
323097001011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097001012	Mg2+ binding site [ion binding]; other site
323097001013	G-X-G motif; other site
323097001014	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
323097001015	anchoring element; other site
323097001016	dimer interface [polypeptide binding]; other site
323097001017	ATP binding site [chemical binding]; other site
323097001018	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
323097001019	active site
323097001020	putative metal-binding site [ion binding]; other site
323097001021	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
323097001022	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
323097001023	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
323097001024	Uncharacterized conserved protein [Function unknown]; Region: COG5470
323097001025	Pirin-related protein [General function prediction only]; Region: COG1741
323097001026	Pirin; Region: Pirin; pfam02678
323097001027	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
323097001028	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
323097001029	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
323097001030	substrate binding site [chemical binding]; other site
323097001031	ATP binding site [chemical binding]; other site
323097001032	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
323097001033	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
323097001034	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
323097001035	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
323097001036	active site
323097001037	HIGH motif; other site
323097001038	dimer interface [polypeptide binding]; other site
323097001039	KMSKS motif; other site
323097001040	Transposase domain (DUF772); Region: DUF772; pfam05598
323097001041	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097001042	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097001043	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323097001044	Ligand Binding Site [chemical binding]; other site
323097001045	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
323097001046	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
323097001047	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
323097001048	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
323097001049	Glycoprotease family; Region: Peptidase_M22; pfam00814
323097001050	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
323097001051	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
323097001052	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
323097001053	metal binding site 2 [ion binding]; metal-binding site
323097001054	putative DNA binding helix; other site
323097001055	metal binding site 1 [ion binding]; metal-binding site
323097001056	dimer interface [polypeptide binding]; other site
323097001057	structural Zn2+ binding site [ion binding]; other site
323097001058	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
323097001059	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
323097001060	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097001061	FeS/SAM binding site; other site
323097001062	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
323097001063	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
323097001064	PhoH-like protein; Region: PhoH; pfam02562
323097001065	metal-binding heat shock protein; Provisional; Region: PRK00016
323097001066	FOG: CBS domain [General function prediction only]; Region: COG0517
323097001067	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
323097001068	Transporter associated domain; Region: CorC_HlyC; smart01091
323097001069	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
323097001070	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
323097001071	putative active site [active]
323097001072	catalytic triad [active]
323097001073	putative dimer interface [polypeptide binding]; other site
323097001074	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323097001075	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097001076	non-specific DNA binding site [nucleotide binding]; other site
323097001077	salt bridge; other site
323097001078	sequence-specific DNA binding site [nucleotide binding]; other site
323097001079	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
323097001080	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
323097001081	Sm and related proteins; Region: Sm_like; cl00259
323097001082	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
323097001083	putative oligomer interface [polypeptide binding]; other site
323097001084	putative RNA binding site [nucleotide binding]; other site
323097001085	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
323097001086	NusA N-terminal domain; Region: NusA_N; pfam08529
323097001087	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
323097001088	RNA binding site [nucleotide binding]; other site
323097001089	homodimer interface [polypeptide binding]; other site
323097001090	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
323097001091	G-X-X-G motif; other site
323097001092	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
323097001093	G-X-X-G motif; other site
323097001094	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
323097001095	hypothetical protein; Provisional; Region: PRK09190
323097001096	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
323097001097	putative RNA binding cleft [nucleotide binding]; other site
323097001098	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
323097001099	translation initiation factor IF-2; Region: IF-2; TIGR00487
323097001100	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
323097001101	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
323097001102	G1 box; other site
323097001103	putative GEF interaction site [polypeptide binding]; other site
323097001104	GTP/Mg2+ binding site [chemical binding]; other site
323097001105	Switch I region; other site
323097001106	G2 box; other site
323097001107	G3 box; other site
323097001108	Switch II region; other site
323097001109	G4 box; other site
323097001110	G5 box; other site
323097001111	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
323097001112	Translation-initiation factor 2; Region: IF-2; pfam11987
323097001113	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
323097001114	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
323097001115	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
323097001116	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
323097001117	RNA binding site [nucleotide binding]; other site
323097001118	active site
323097001119	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
323097001120	16S/18S rRNA binding site [nucleotide binding]; other site
323097001121	S13e-L30e interaction site [polypeptide binding]; other site
323097001122	25S rRNA binding site [nucleotide binding]; other site
323097001123	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
323097001124	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
323097001125	RNase E interface [polypeptide binding]; other site
323097001126	trimer interface [polypeptide binding]; other site
323097001127	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
323097001128	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
323097001129	RNase E interface [polypeptide binding]; other site
323097001130	trimer interface [polypeptide binding]; other site
323097001131	active site
323097001132	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
323097001133	putative nucleic acid binding region [nucleotide binding]; other site
323097001134	G-X-X-G motif; other site
323097001135	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
323097001136	RNA binding site [nucleotide binding]; other site
323097001137	domain interface; other site
323097001138	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
323097001139	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097001140	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
323097001141	dimerization interface [polypeptide binding]; other site
323097001142	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
323097001143	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
323097001144	dimer interface [polypeptide binding]; other site
323097001145	active site
323097001146	heme binding site [chemical binding]; other site
323097001147	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
323097001148	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323097001149	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
323097001150	putative GSH binding site (G-site) [chemical binding]; other site
323097001151	putative C-terminal domain interface [polypeptide binding]; other site
323097001152	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
323097001153	dimer interface [polypeptide binding]; other site
323097001154	N-terminal domain interface [polypeptide binding]; other site
323097001155	putative substrate binding pocket (H-site) [chemical binding]; other site
323097001156	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
323097001157	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
323097001158	NAD binding site [chemical binding]; other site
323097001159	homotetramer interface [polypeptide binding]; other site
323097001160	homodimer interface [polypeptide binding]; other site
323097001161	substrate binding site [chemical binding]; other site
323097001162	active site
323097001163	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
323097001164	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
323097001165	dimer interface [polypeptide binding]; other site
323097001166	active site
323097001167	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
323097001168	active site 1 [active]
323097001169	dimer interface [polypeptide binding]; other site
323097001170	active site 2 [active]
323097001171	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
323097001172	metal binding site 2 [ion binding]; metal-binding site
323097001173	putative DNA binding helix; other site
323097001174	metal binding site 1 [ion binding]; metal-binding site
323097001175	dimer interface [polypeptide binding]; other site
323097001176	structural Zn2+ binding site [ion binding]; other site
323097001177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
323097001178	Bacterial SH3 domain; Region: SH3_4; pfam06347
323097001179	Bacterial SH3 domain; Region: SH3_4; pfam06347
323097001180	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
323097001181	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
323097001182	dimerization interface [polypeptide binding]; other site
323097001183	ligand binding site [chemical binding]; other site
323097001184	NADP binding site [chemical binding]; other site
323097001185	catalytic site [active]
323097001186	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
323097001187	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
323097001188	ATP binding site [chemical binding]; other site
323097001189	substrate interface [chemical binding]; other site
323097001190	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323097001191	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
323097001192	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
323097001193	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
323097001194	DNA binding site [nucleotide binding]
323097001195	catalytic residue [active]
323097001196	H2TH interface [polypeptide binding]; other site
323097001197	putative catalytic residues [active]
323097001198	turnover-facilitating residue; other site
323097001199	intercalation triad [nucleotide binding]; other site
323097001200	8OG recognition residue [nucleotide binding]; other site
323097001201	putative reading head residues; other site
323097001202	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
323097001203	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
323097001204	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
323097001205	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097001206	S-adenosylmethionine binding site [chemical binding]; other site
323097001207	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
323097001208	ABC1 family; Region: ABC1; cl17513
323097001209	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
323097001210	active site
323097001211	ATP binding site [chemical binding]; other site
323097001212	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
323097001213	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
323097001214	Flavoprotein; Region: Flavoprotein; pfam02441
323097001215	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
323097001216	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
323097001217	trimer interface [polypeptide binding]; other site
323097001218	active site
323097001219	PAS fold; Region: PAS_7; pfam12860
323097001220	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323097001221	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097001222	dimer interface [polypeptide binding]; other site
323097001223	phosphorylation site [posttranslational modification]
323097001224	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097001225	ATP binding site [chemical binding]; other site
323097001226	Mg2+ binding site [ion binding]; other site
323097001227	G-X-G motif; other site
323097001228	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
323097001229	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
323097001230	Phosphotransferase enzyme family; Region: APH; pfam01636
323097001231	PilZ domain; Region: PilZ; pfam07238
323097001232	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
323097001233	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
323097001234	Substrate binding site; other site
323097001235	metal-binding site
323097001236	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
323097001237	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
323097001238	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
323097001239	Part of AAA domain; Region: AAA_19; pfam13245
323097001240	Family description; Region: UvrD_C_2; pfam13538
323097001241	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
323097001242	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
323097001243	catalytic residues [active]
323097001244	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
323097001245	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323097001246	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
323097001247	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
323097001248	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
323097001249	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
323097001250	substrate binding site [chemical binding]; other site
323097001251	active site
323097001252	catalytic residues [active]
323097001253	heterodimer interface [polypeptide binding]; other site
323097001254	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
323097001255	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
323097001256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097001257	catalytic residue [active]
323097001258	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
323097001259	active site
323097001260	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
323097001261	IHF dimer interface [polypeptide binding]; other site
323097001262	IHF - DNA interface [nucleotide binding]; other site
323097001263	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
323097001264	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
323097001265	tandem repeat interface [polypeptide binding]; other site
323097001266	oligomer interface [polypeptide binding]; other site
323097001267	active site residues [active]
323097001268	CysZ-like protein; Reviewed; Region: PRK12768
323097001269	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
323097001270	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323097001271	catalytic residues [active]
323097001272	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
323097001273	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
323097001274	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
323097001275	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
323097001276	Ligand Binding Site [chemical binding]; other site
323097001277	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
323097001278	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
323097001279	putative tRNA-binding site [nucleotide binding]; other site
323097001280	B3/4 domain; Region: B3_4; pfam03483
323097001281	tRNA synthetase B5 domain; Region: B5; smart00874
323097001282	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
323097001283	dimer interface [polypeptide binding]; other site
323097001284	motif 1; other site
323097001285	motif 3; other site
323097001286	motif 2; other site
323097001287	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
323097001288	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
323097001289	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
323097001290	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
323097001291	dimer interface [polypeptide binding]; other site
323097001292	motif 1; other site
323097001293	active site
323097001294	motif 2; other site
323097001295	motif 3; other site
323097001296	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
323097001297	23S rRNA binding site [nucleotide binding]; other site
323097001298	L21 binding site [polypeptide binding]; other site
323097001299	L13 binding site [polypeptide binding]; other site
323097001300	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
323097001301	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
323097001302	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
323097001303	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
323097001304	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
323097001305	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
323097001306	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097001307	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323097001308	putative active site [active]
323097001309	heme pocket [chemical binding]; other site
323097001310	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323097001311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097001312	putative active site [active]
323097001313	heme pocket [chemical binding]; other site
323097001314	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323097001315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097001316	putative active site [active]
323097001317	heme pocket [chemical binding]; other site
323097001318	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097001319	putative active site [active]
323097001320	heme pocket [chemical binding]; other site
323097001321	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
323097001322	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
323097001323	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
323097001324	Uncharacterized conserved protein [Function unknown]; Region: COG2835
323097001325	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
323097001326	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
323097001327	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323097001328	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
323097001329	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323097001330	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
323097001331	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
323097001332	active site
323097001333	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
323097001334	catalytic triad [active]
323097001335	dimer interface [polypeptide binding]; other site
323097001336	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
323097001337	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323097001338	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
323097001339	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323097001340	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097001341	homodimer interface [polypeptide binding]; other site
323097001342	catalytic residue [active]
323097001343	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
323097001344	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
323097001345	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
323097001346	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
323097001347	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
323097001348	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
323097001349	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
323097001350	putative catalytic site [active]
323097001351	putative phosphate binding site [ion binding]; other site
323097001352	active site
323097001353	metal binding site A [ion binding]; metal-binding site
323097001354	DNA binding site [nucleotide binding]
323097001355	putative AP binding site [nucleotide binding]; other site
323097001356	putative metal binding site B [ion binding]; other site
323097001357	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323097001358	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323097001359	ligand binding site [chemical binding]; other site
323097001360	flexible hinge region; other site
323097001361	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097001362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097001363	active site
323097001364	phosphorylation site [posttranslational modification]
323097001365	intermolecular recognition site; other site
323097001366	dimerization interface [polypeptide binding]; other site
323097001367	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097001368	DNA binding site [nucleotide binding]
323097001369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
323097001370	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
323097001371	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323097001372	catalytic residue [active]
323097001373	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323097001374	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
323097001375	C-terminal domain interface [polypeptide binding]; other site
323097001376	GSH binding site (G-site) [chemical binding]; other site
323097001377	dimer interface [polypeptide binding]; other site
323097001378	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
323097001379	dimer interface [polypeptide binding]; other site
323097001380	N-terminal domain interface [polypeptide binding]; other site
323097001381	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
323097001382	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
323097001383	HIGH motif; other site
323097001384	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
323097001385	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323097001386	active site
323097001387	KMSKS motif; other site
323097001388	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
323097001389	tRNA binding surface [nucleotide binding]; other site
323097001390	Lipopolysaccharide-assembly; Region: LptE; pfam04390
323097001391	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
323097001392	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
323097001393	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
323097001394	GIY-YIG motif/motif A; other site
323097001395	putative active site [active]
323097001396	putative metal binding site [ion binding]; other site
323097001397	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
323097001398	ParB-like nuclease domain; Region: ParB; smart00470
323097001399	KorB domain; Region: KorB; pfam08535
323097001400	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323097001401	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097001402	P-loop; other site
323097001403	Magnesium ion binding site [ion binding]; other site
323097001404	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
323097001405	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
323097001406	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
323097001407	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
323097001408	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
323097001409	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
323097001410	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
323097001411	trmE is a tRNA modification GTPase; Region: trmE; cd04164
323097001412	G1 box; other site
323097001413	GTP/Mg2+ binding site [chemical binding]; other site
323097001414	Switch I region; other site
323097001415	G2 box; other site
323097001416	Switch II region; other site
323097001417	G3 box; other site
323097001418	G4 box; other site
323097001419	G5 box; other site
323097001420	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
323097001421	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
323097001422	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
323097001423	catalytic residues [active]
323097001424	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
323097001425	transcription termination factor Rho; Provisional; Region: rho; PRK09376
323097001426	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
323097001427	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
323097001428	RNA binding site [nucleotide binding]; other site
323097001429	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
323097001430	multimer interface [polypeptide binding]; other site
323097001431	Walker A motif; other site
323097001432	ATP binding site [chemical binding]; other site
323097001433	Walker B motif; other site
323097001434	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097001435	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097001436	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097001437	Transposase, Mutator family; Region: Transposase_mut; pfam00872
323097001438	MULE transposase domain; Region: MULE; pfam10551
323097001439	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
323097001440	PEP synthetase regulatory protein; Provisional; Region: PRK05339
323097001441	Maf-like protein; Region: Maf; pfam02545
323097001442	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
323097001443	active site
323097001444	dimer interface [polypeptide binding]; other site
323097001445	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
323097001446	dephospho-CoA kinase; Region: TIGR00152
323097001447	CoA-binding site [chemical binding]; other site
323097001448	ATP-binding [chemical binding]; other site
323097001449	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
323097001450	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
323097001451	active site
323097001452	catalytic site [active]
323097001453	substrate binding site [chemical binding]; other site
323097001454	preprotein translocase subunit SecB; Validated; Region: PRK05751
323097001455	SecA binding site; other site
323097001456	Preprotein binding site; other site
323097001457	Tim44-like domain; Region: Tim44; pfam04280
323097001458	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
323097001459	MltA specific insert domain; Region: MltA; smart00925
323097001460	3D domain; Region: 3D; pfam06725
323097001461	Smr domain; Region: Smr; pfam01713
323097001462	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
323097001463	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
323097001464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097001465	Walker A motif; other site
323097001466	ATP binding site [chemical binding]; other site
323097001467	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
323097001468	Walker B motif; other site
323097001469	arginine finger; other site
323097001470	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
323097001471	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
323097001472	active site
323097001473	HslU subunit interaction site [polypeptide binding]; other site
323097001474	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
323097001475	putative active site pocket [active]
323097001476	4-fold oligomerization interface [polypeptide binding]; other site
323097001477	metal binding residues [ion binding]; metal-binding site
323097001478	3-fold/trimer interface [polypeptide binding]; other site
323097001479	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
323097001480	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
323097001481	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
323097001482	putative active site [active]
323097001483	oxyanion strand; other site
323097001484	catalytic triad [active]
323097001485	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
323097001486	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
323097001487	catalytic residues [active]
323097001488	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
323097001489	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
323097001490	substrate binding site [chemical binding]; other site
323097001491	glutamase interaction surface [polypeptide binding]; other site
323097001492	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
323097001493	metal binding site [ion binding]; metal-binding site
323097001494	pantothenate kinase; Provisional; Region: PRK05439
323097001495	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
323097001496	ATP-binding site [chemical binding]; other site
323097001497	CoA-binding site [chemical binding]; other site
323097001498	Mg2+-binding site [ion binding]; other site
323097001499	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
323097001500	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097001501	putative active site [active]
323097001502	heme pocket [chemical binding]; other site
323097001503	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097001504	dimer interface [polypeptide binding]; other site
323097001505	phosphorylation site [posttranslational modification]
323097001506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097001507	ATP binding site [chemical binding]; other site
323097001508	Mg2+ binding site [ion binding]; other site
323097001509	G-X-G motif; other site
323097001510	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323097001511	Response regulator receiver domain; Region: Response_reg; pfam00072
323097001512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097001513	active site
323097001514	phosphorylation site [posttranslational modification]
323097001515	intermolecular recognition site; other site
323097001516	dimerization interface [polypeptide binding]; other site
323097001517	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
323097001518	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
323097001519	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
323097001520	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097001521	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097001522	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097001523	Trp repressor protein; Region: Trp_repressor; cl17266
323097001524	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097001525	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323097001526	catalytic residues [active]
323097001527	catalytic nucleophile [active]
323097001528	Recombinase; Region: Recombinase; pfam07508
323097001529	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323097001530	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
323097001531	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
323097001532	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
323097001533	glutathione synthetase; Provisional; Region: PRK05246
323097001534	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
323097001535	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
323097001536	hypothetical protein; Reviewed; Region: PRK12497
323097001537	Predicted methyltransferases [General function prediction only]; Region: COG0313
323097001538	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
323097001539	putative SAM binding site [chemical binding]; other site
323097001540	putative homodimer interface [polypeptide binding]; other site
323097001541	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
323097001542	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
323097001543	putative ligand binding site [chemical binding]; other site
323097001544	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
323097001545	HemN C-terminal domain; Region: HemN_C; pfam06969
323097001546	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
323097001547	active site
323097001548	dimerization interface [polypeptide binding]; other site
323097001549	ribonuclease PH; Reviewed; Region: rph; PRK00173
323097001550	Ribonuclease PH; Region: RNase_PH_bact; cd11362
323097001551	hexamer interface [polypeptide binding]; other site
323097001552	active site
323097001553	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
323097001554	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
323097001555	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
323097001556	dimer interface [polypeptide binding]; other site
323097001557	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
323097001558	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
323097001559	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
323097001560	nucleotide binding site [chemical binding]; other site
323097001561	NEF interaction site [polypeptide binding]; other site
323097001562	SBD interface [polypeptide binding]; other site
323097001563	chaperone protein DnaJ; Provisional; Region: PRK10767
323097001564	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
323097001565	HSP70 interaction site [polypeptide binding]; other site
323097001566	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
323097001567	substrate binding site [polypeptide binding]; other site
323097001568	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
323097001569	Zn binding sites [ion binding]; other site
323097001570	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
323097001571	dimer interface [polypeptide binding]; other site
323097001572	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097001573	S-adenosylmethionine binding site [chemical binding]; other site
323097001574	dihydrodipicolinate reductase; Provisional; Region: PRK00048
323097001575	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
323097001576	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
323097001577	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323097001578	catalytic core [active]
323097001579	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
323097001580	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
323097001581	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
323097001582	DNA binding site [nucleotide binding]
323097001583	active site
323097001584	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
323097001585	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
323097001586	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
323097001587	minor groove reading motif; other site
323097001588	helix-hairpin-helix signature motif; other site
323097001589	substrate binding pocket [chemical binding]; other site
323097001590	active site
323097001591	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
323097001592	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
323097001593	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
323097001594	RNA binding site [nucleotide binding]; other site
323097001595	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
323097001596	RNA binding site [nucleotide binding]; other site
323097001597	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
323097001598	RNA binding site [nucleotide binding]; other site
323097001599	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
323097001600	RNA binding site [nucleotide binding]; other site
323097001601	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
323097001602	RNA binding site [nucleotide binding]; other site
323097001603	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
323097001604	RNA binding site [nucleotide binding]; other site
323097001605	cytidylate kinase; Provisional; Region: cmk; PRK00023
323097001606	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
323097001607	CMP-binding site; other site
323097001608	The sites determining sugar specificity; other site
323097001609	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
323097001610	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
323097001611	hinge; other site
323097001612	active site
323097001613	TIGR02300 family protein; Region: FYDLN_acid
323097001614	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
323097001615	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323097001616	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
323097001617	putative dimer interface [polypeptide binding]; other site
323097001618	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
323097001619	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
323097001620	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
323097001621	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
323097001622	active site
323097001623	phosphorylation site [posttranslational modification]
323097001624	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
323097001625	30S subunit binding site; other site
323097001626	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
323097001627	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
323097001628	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
323097001629	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
323097001630	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
323097001631	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
323097001632	Walker A/P-loop; other site
323097001633	ATP binding site [chemical binding]; other site
323097001634	Q-loop/lid; other site
323097001635	ABC transporter signature motif; other site
323097001636	Walker B; other site
323097001637	D-loop; other site
323097001638	H-loop/switch region; other site
323097001639	OstA-like protein; Region: OstA; pfam03968
323097001640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
323097001641	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
323097001642	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
323097001643	catalytic site [active]
323097001644	putative active site [active]
323097001645	putative substrate binding site [chemical binding]; other site
323097001646	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
323097001647	putative metal binding site [ion binding]; other site
323097001648	Uncharacterized conserved protein [Function unknown]; Region: COG1432
323097001649	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
323097001650	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
323097001651	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
323097001652	putative NAD(P) binding site [chemical binding]; other site
323097001653	active site
323097001654	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
323097001655	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323097001656	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
323097001657	C-terminal domain interface [polypeptide binding]; other site
323097001658	GSH binding site (G-site) [chemical binding]; other site
323097001659	dimer interface [polypeptide binding]; other site
323097001660	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
323097001661	N-terminal domain interface [polypeptide binding]; other site
323097001662	dimer interface [polypeptide binding]; other site
323097001663	substrate binding pocket (H-site) [chemical binding]; other site
323097001664	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
323097001665	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
323097001666	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
323097001667	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
323097001668	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
323097001669	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
323097001670	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
323097001671	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
323097001672	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
323097001673	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
323097001674	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
323097001675	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
323097001676	Cytochrome c [Energy production and conversion]; Region: COG3258
323097001677	Cytochrome c; Region: Cytochrom_C; pfam00034
323097001678	Cytochrome c; Region: Cytochrom_C; cl11414
323097001679	Cytochrome c553 [Energy production and conversion]; Region: COG2863
323097001680	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
323097001681	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
323097001682	purine monophosphate binding site [chemical binding]; other site
323097001683	dimer interface [polypeptide binding]; other site
323097001684	putative catalytic residues [active]
323097001685	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
323097001686	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
323097001687	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
323097001688	NusB family; Region: NusB; pfam01029
323097001689	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
323097001690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097001691	S-adenosylmethionine binding site [chemical binding]; other site
323097001692	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
323097001693	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
323097001694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323097001695	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097001696	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
323097001697	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323097001698	active site
323097001699	nucleotide binding site [chemical binding]; other site
323097001700	HIGH motif; other site
323097001701	KMSKS motif; other site
323097001702	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
323097001703	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
323097001704	substrate binding pocket [chemical binding]; other site
323097001705	membrane-bound complex binding site; other site
323097001706	hinge residues; other site
323097001707	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
323097001708	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323097001709	active site
323097001710	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
323097001711	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
323097001712	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097001713	non-specific DNA binding site [nucleotide binding]; other site
323097001714	salt bridge; other site
323097001715	sequence-specific DNA binding site [nucleotide binding]; other site
323097001716	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
323097001717	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323097001718	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
323097001719	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323097001720	Cu(I) binding site [ion binding]; other site
323097001721	RNA polymerase sigma factor; Provisional; Region: PRK11922
323097001722	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323097001723	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323097001724	DNA binding residues [nucleotide binding]
323097001725	Predicted outer membrane protein [Function unknown]; Region: COG3652
323097001726	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
323097001727	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
323097001728	camphor resistance protein CrcB; Provisional; Region: PRK14195
323097001729	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
323097001730	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
323097001731	trimer interface [polypeptide binding]; other site
323097001732	active site
323097001733	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
323097001734	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
323097001735	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
323097001736	homodimer interface [polypeptide binding]; other site
323097001737	substrate-cofactor binding pocket; other site
323097001738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097001739	catalytic residue [active]
323097001740	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
323097001741	active site
323097001742	catalytic triad [active]
323097001743	oxyanion hole [active]
323097001744	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
323097001745	oxyanion hole [active]
323097001746	OpgC protein; Region: OpgC_C; pfam10129
323097001747	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
323097001748	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
323097001749	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
323097001750	dimerization interface [polypeptide binding]; other site
323097001751	domain crossover interface; other site
323097001752	redox-dependent activation switch; other site
323097001753	OsmC-like protein; Region: OsmC; pfam02566
323097001754	PII uridylyl-transferase; Provisional; Region: PRK05092
323097001755	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
323097001756	metal binding triad; other site
323097001757	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
323097001758	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
323097001759	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
323097001760	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
323097001761	Transglycosylase; Region: Transgly; pfam00912
323097001762	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
323097001763	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
323097001764	Protein of unknown function DUF45; Region: DUF45; pfam01863
323097001765	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
323097001766	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
323097001767	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097001768	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097001769	dimer interface [polypeptide binding]; other site
323097001770	phosphorylation site [posttranslational modification]
323097001771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097001772	ATP binding site [chemical binding]; other site
323097001773	Mg2+ binding site [ion binding]; other site
323097001774	G-X-G motif; other site
323097001775	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
323097001776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097001777	active site
323097001778	phosphorylation site [posttranslational modification]
323097001779	intermolecular recognition site; other site
323097001780	dimerization interface [polypeptide binding]; other site
323097001781	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
323097001782	Protein of unknown function (DUF1052); Region: DUF1052; pfam06319
323097001783	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
323097001784	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
323097001785	PAS fold; Region: PAS_3; pfam08447
323097001786	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
323097001787	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097001788	PAS fold; Region: PAS_3; pfam08447
323097001789	putative active site [active]
323097001790	heme pocket [chemical binding]; other site
323097001791	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097001792	PAS domain; Region: PAS_9; pfam13426
323097001793	putative active site [active]
323097001794	heme pocket [chemical binding]; other site
323097001795	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097001796	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097001797	dimer interface [polypeptide binding]; other site
323097001798	phosphorylation site [posttranslational modification]
323097001799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097001800	ATP binding site [chemical binding]; other site
323097001801	Mg2+ binding site [ion binding]; other site
323097001802	G-X-G motif; other site
323097001803	Response regulator receiver domain; Region: Response_reg; pfam00072
323097001804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097001805	active site
323097001806	phosphorylation site [posttranslational modification]
323097001807	intermolecular recognition site; other site
323097001808	dimerization interface [polypeptide binding]; other site
323097001809	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
323097001810	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323097001811	ligand binding site [chemical binding]; other site
323097001812	heat shock protein HtpX; Provisional; Region: PRK01345
323097001813	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
323097001814	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
323097001815	Coenzyme A binding pocket [chemical binding]; other site
323097001816	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323097001817	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323097001818	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
323097001819	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097001820	ATP binding site [chemical binding]; other site
323097001821	putative Mg++ binding site [ion binding]; other site
323097001822	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097001823	nucleotide binding region [chemical binding]; other site
323097001824	ATP-binding site [chemical binding]; other site
323097001825	DEAD/H associated; Region: DEAD_assoc; pfam08494
323097001826	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323097001827	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
323097001828	putative active site [active]
323097001829	putative metal binding site [ion binding]; other site
323097001830	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323097001831	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097001832	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323097001833	dimerization interface [polypeptide binding]; other site
323097001834	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
323097001835	EamA-like transporter family; Region: EamA; pfam00892
323097001836	EamA-like transporter family; Region: EamA; pfam00892
323097001837	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
323097001838	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
323097001839	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097001840	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097001841	Transposase domain (DUF772); Region: DUF772; pfam05598
323097001842	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323097001843	Sel1-like repeats; Region: SEL1; smart00671
323097001844	Sel1-like repeats; Region: SEL1; smart00671
323097001845	Sel1 repeat; Region: Sel1; pfam08238
323097001846	Sel1-like repeats; Region: SEL1; smart00671
323097001847	MarR family; Region: MarR_2; pfam12802
323097001848	Transcriptional regulators [Transcription]; Region: MarR; COG1846
323097001849	glutamate--cysteine ligase; Region: PLN02611
323097001850	PAN domain; Region: PAN_4; pfam14295
323097001851	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
323097001852	putative binding site; other site
323097001853	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
323097001854	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
323097001855	Catalytic site [active]
323097001856	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
323097001857	protease TldD; Provisional; Region: tldD; PRK10735
323097001858	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
323097001859	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
323097001860	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
323097001861	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
323097001862	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323097001863	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
323097001864	Subunit I/III interface [polypeptide binding]; other site
323097001865	D-pathway; other site
323097001866	Subunit I/VIIc interface [polypeptide binding]; other site
323097001867	Subunit I/IV interface [polypeptide binding]; other site
323097001868	Subunit I/II interface [polypeptide binding]; other site
323097001869	Low-spin heme (heme a) binding site [chemical binding]; other site
323097001870	Subunit I/VIIa interface [polypeptide binding]; other site
323097001871	Subunit I/VIa interface [polypeptide binding]; other site
323097001872	Dimer interface; other site
323097001873	Putative water exit pathway; other site
323097001874	Binuclear center (heme a3/CuB) [ion binding]; other site
323097001875	K-pathway; other site
323097001876	Subunit I/Vb interface [polypeptide binding]; other site
323097001877	Putative proton exit pathway; other site
323097001878	Subunit I/VIb interface; other site
323097001879	Subunit I/VIc interface [polypeptide binding]; other site
323097001880	Electron transfer pathway; other site
323097001881	Subunit I/VIIIb interface [polypeptide binding]; other site
323097001882	Subunit I/VIIb interface [polypeptide binding]; other site
323097001883	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
323097001884	UbiA prenyltransferase family; Region: UbiA; pfam01040
323097001885	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
323097001886	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
323097001887	Subunit III/VIIa interface [polypeptide binding]; other site
323097001888	Phospholipid binding site [chemical binding]; other site
323097001889	Subunit I/III interface [polypeptide binding]; other site
323097001890	Subunit III/VIb interface [polypeptide binding]; other site
323097001891	Subunit III/VIa interface; other site
323097001892	Subunit III/Vb interface [polypeptide binding]; other site
323097001893	Protein of unknown function (DUF983); Region: DUF983; cl02211
323097001894	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
323097001895	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
323097001896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097001897	catalytic residue [active]
323097001898	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
323097001899	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
323097001900	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
323097001901	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
323097001902	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
323097001903	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
323097001904	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
323097001905	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
323097001906	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
323097001907	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
323097001908	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
323097001909	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
323097001910	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
323097001911	BA14K-like protein; Region: BA14K; pfam07886
323097001912	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
323097001913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097001914	active site
323097001915	phosphorylation site [posttranslational modification]
323097001916	intermolecular recognition site; other site
323097001917	dimerization interface [polypeptide binding]; other site
323097001918	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323097001919	DNA binding residues [nucleotide binding]
323097001920	dimerization interface [polypeptide binding]; other site
323097001921	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
323097001922	Na binding site [ion binding]; other site
323097001923	PAS fold; Region: PAS_7; pfam12860
323097001924	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097001925	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097001926	dimer interface [polypeptide binding]; other site
323097001927	phosphorylation site [posttranslational modification]
323097001928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097001929	ATP binding site [chemical binding]; other site
323097001930	Mg2+ binding site [ion binding]; other site
323097001931	G-X-G motif; other site
323097001932	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323097001933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097001934	active site
323097001935	phosphorylation site [posttranslational modification]
323097001936	intermolecular recognition site; other site
323097001937	dimerization interface [polypeptide binding]; other site
323097001938	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
323097001939	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
323097001940	substrate-cofactor binding pocket; other site
323097001941	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097001942	catalytic residue [active]
323097001943	biotin synthase; Region: bioB; TIGR00433
323097001944	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097001945	FeS/SAM binding site; other site
323097001946	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
323097001947	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323097001948	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097001949	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323097001950	catalytic residues [active]
323097001951	catalytic nucleophile [active]
323097001952	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097001953	active site
323097001954	DNA binding site [nucleotide binding]
323097001955	Int/Topo IB signature motif; other site
323097001956	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
323097001957	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
323097001958	hinge; other site
323097001959	active site
323097001960	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
323097001961	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
323097001962	NAD binding site [chemical binding]; other site
323097001963	dimerization interface [polypeptide binding]; other site
323097001964	product binding site; other site
323097001965	substrate binding site [chemical binding]; other site
323097001966	zinc binding site [ion binding]; other site
323097001967	catalytic residues [active]
323097001968	hypothetical protein; Provisional; Region: PRK02853
323097001969	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
323097001970	Low molecular weight phosphatase family; Region: LMWPc; cd00115
323097001971	active site
323097001972	DDE superfamily endonuclease; Region: DDE_5; pfam13546
323097001973	Maf-like protein; Region: Maf; pfam02545
323097001974	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
323097001975	active site
323097001976	dimer interface [polypeptide binding]; other site
323097001977	zinc-binding protein; Provisional; Region: PRK01343
323097001978	integrase; Provisional; Region: PRK09692
323097001979	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
323097001980	active site
323097001981	Int/Topo IB signature motif; other site
323097001982	AAA-like domain; Region: AAA_10; pfam12846
323097001983	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
323097001984	AAA-like domain; Region: AAA_10; pfam12846
323097001985	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
323097001986	dimer interface [polypeptide binding]; other site
323097001987	HNH endonuclease; Region: HNH_3; pfam13392
323097001988	DNA primase; Validated; Region: dnaG; PRK05667
323097001989	YopX protein; Region: YopX; pfam09643
323097001990	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
323097001991	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
323097001992	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
323097001993	putative L-valine exporter; Provisional; Region: PRK10408
323097001994	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
323097001995	DNA binding residues [nucleotide binding]
323097001996	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
323097001997	Integrase core domain; Region: rve; pfam00665
323097001998	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
323097001999	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097002000	Walker A motif; other site
323097002001	ATP binding site [chemical binding]; other site
323097002002	Walker B motif; other site
323097002003	arginine finger; other site
323097002004	hypothetical protein; Provisional; Region: PRK09741
323097002005	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
323097002006	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
323097002007	active site
323097002008	catalytic residues [active]
323097002009	DNA binding site [nucleotide binding]
323097002010	Int/Topo IB signature motif; other site
323097002011	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
323097002012	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
323097002013	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
323097002014	active site
323097002015	catalytic site [active]
323097002016	substrate binding site [chemical binding]; other site
323097002017	BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533
323097002018	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
323097002019	Phage Terminase; Region: Terminase_1; pfam03354
323097002020	Phage terminase, small subunit; Region: Terminase_4; pfam05119
323097002021	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
323097002022	Phage capsid family; Region: Phage_capsid; pfam05065
323097002023	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
323097002024	Phage portal protein; Region: Phage_portal; pfam04860
323097002025	Phage-related protein [Function unknown]; Region: COG4695; cl01923
323097002026	AAA domain; Region: AAA_25; pfam13481
323097002027	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323097002028	ATP binding site [chemical binding]; other site
323097002029	Walker A motif; other site
323097002030	Walker B motif; other site
323097002031	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
323097002032	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323097002033	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
323097002034	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
323097002035	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
323097002036	Walker A/P-loop; other site
323097002037	ATP binding site [chemical binding]; other site
323097002038	Q-loop/lid; other site
323097002039	ABC transporter signature motif; other site
323097002040	Walker B; other site
323097002041	D-loop; other site
323097002042	H-loop/switch region; other site
323097002043	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
323097002044	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
323097002045	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
323097002046	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
323097002047	dimer interface [polypeptide binding]; other site
323097002048	active site residues [active]
323097002049	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
323097002050	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097002051	dimer interface [polypeptide binding]; other site
323097002052	phosphorylation site [posttranslational modification]
323097002053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097002054	ATP binding site [chemical binding]; other site
323097002055	Mg2+ binding site [ion binding]; other site
323097002056	G-X-G motif; other site
323097002057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097002058	active site
323097002059	phosphorylation site [posttranslational modification]
323097002060	intermolecular recognition site; other site
323097002061	dimerization interface [polypeptide binding]; other site
323097002062	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
323097002063	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
323097002064	TM-ABC transporter signature motif; other site
323097002065	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
323097002066	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
323097002067	TM-ABC transporter signature motif; other site
323097002068	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
323097002069	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
323097002070	putative ligand binding site [chemical binding]; other site
323097002071	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
323097002072	heme-binding site [chemical binding]; other site
323097002073	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
323097002074	dimer interface [polypeptide binding]; other site
323097002075	putative CheW interface [polypeptide binding]; other site
323097002076	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
323097002077	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
323097002078	Walker A/P-loop; other site
323097002079	ATP binding site [chemical binding]; other site
323097002080	Q-loop/lid; other site
323097002081	ABC transporter signature motif; other site
323097002082	Walker B; other site
323097002083	D-loop; other site
323097002084	H-loop/switch region; other site
323097002085	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
323097002086	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
323097002087	Walker A/P-loop; other site
323097002088	ATP binding site [chemical binding]; other site
323097002089	Q-loop/lid; other site
323097002090	ABC transporter signature motif; other site
323097002091	Walker B; other site
323097002092	D-loop; other site
323097002093	H-loop/switch region; other site
323097002094	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
323097002095	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
323097002096	substrate binding site [chemical binding]; other site
323097002097	oxyanion hole (OAH) forming residues; other site
323097002098	trimer interface [polypeptide binding]; other site
323097002099	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
323097002100	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
323097002101	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
323097002102	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
323097002103	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
323097002104	dimer interface [polypeptide binding]; other site
323097002105	active site
323097002106	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
323097002107	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
323097002108	N- and C-terminal domain interface [polypeptide binding]; other site
323097002109	active site
323097002110	MgATP binding site [chemical binding]; other site
323097002111	catalytic site [active]
323097002112	metal binding site [ion binding]; metal-binding site
323097002113	glycerol binding site [chemical binding]; other site
323097002114	homotetramer interface [polypeptide binding]; other site
323097002115	homodimer interface [polypeptide binding]; other site
323097002116	FBP binding site [chemical binding]; other site
323097002117	protein IIAGlc interface [polypeptide binding]; other site
323097002118	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
323097002119	active site clefts [active]
323097002120	zinc binding site [ion binding]; other site
323097002121	dimer interface [polypeptide binding]; other site
323097002122	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097002123	PAS domain; Region: PAS_9; pfam13426
323097002124	putative active site [active]
323097002125	heme pocket [chemical binding]; other site
323097002126	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
323097002127	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
323097002128	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
323097002129	substrate binding pocket [chemical binding]; other site
323097002130	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
323097002131	B12 binding site [chemical binding]; other site
323097002132	cobalt ligand [ion binding]; other site
323097002133	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
323097002134	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
323097002135	FAD binding site [chemical binding]; other site
323097002136	prephenate dehydratase; Provisional; Region: PRK11899
323097002137	Prephenate dehydratase; Region: PDT; pfam00800
323097002138	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
323097002139	putative L-Phe binding site [chemical binding]; other site
323097002140	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097002141	DNA-binding site [nucleotide binding]; DNA binding site
323097002142	RNA-binding motif; other site
323097002143	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
323097002144	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
323097002145	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
323097002146	Ligand binding site; other site
323097002147	oligomer interface; other site
323097002148	Cytochrome c2 [Energy production and conversion]; Region: COG3474
323097002149	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
323097002150	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
323097002151	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
323097002152	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
323097002153	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
323097002154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097002155	dimer interface [polypeptide binding]; other site
323097002156	conserved gate region; other site
323097002157	putative PBP binding loops; other site
323097002158	ABC-ATPase subunit interface; other site
323097002159	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
323097002160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097002161	dimer interface [polypeptide binding]; other site
323097002162	conserved gate region; other site
323097002163	putative PBP binding loops; other site
323097002164	ABC-ATPase subunit interface; other site
323097002165	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
323097002166	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
323097002167	Walker A/P-loop; other site
323097002168	ATP binding site [chemical binding]; other site
323097002169	Q-loop/lid; other site
323097002170	ABC transporter signature motif; other site
323097002171	Walker B; other site
323097002172	D-loop; other site
323097002173	H-loop/switch region; other site
323097002174	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
323097002175	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
323097002176	Walker A/P-loop; other site
323097002177	ATP binding site [chemical binding]; other site
323097002178	Q-loop/lid; other site
323097002179	ABC transporter signature motif; other site
323097002180	Walker B; other site
323097002181	D-loop; other site
323097002182	H-loop/switch region; other site
323097002183	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
323097002184	Src Homology 3 domain superfamily; Region: SH3; cl17036
323097002185	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
323097002186	NlpC/P60 family; Region: NLPC_P60; pfam00877
323097002187	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
323097002188	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
323097002189	interface (dimer of trimers) [polypeptide binding]; other site
323097002190	Substrate-binding/catalytic site; other site
323097002191	Zn-binding sites [ion binding]; other site
323097002192	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
323097002193	binding surface
323097002194	TPR motif; other site
323097002195	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097002196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097002197	TPR motif; other site
323097002198	binding surface
323097002199	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
323097002200	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
323097002201	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
323097002202	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
323097002203	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
323097002204	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
323097002205	ATP binding site [chemical binding]; other site
323097002206	Walker A motif; other site
323097002207	hexamer interface [polypeptide binding]; other site
323097002208	Walker B motif; other site
323097002209	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
323097002210	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
323097002211	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
323097002212	Type IV pili component [Cell motility and secretion]; Region: COG5461
323097002213	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
323097002214	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
323097002215	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
323097002216	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
323097002217	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
323097002218	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
323097002219	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
323097002220	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
323097002221	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
323097002222	TadE-like protein; Region: TadE; pfam07811
323097002223	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097002224	DNA-binding site [nucleotide binding]; DNA binding site
323097002225	RNA-binding motif; other site
323097002226	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
323097002227	rRNA binding site [nucleotide binding]; other site
323097002228	predicted 30S ribosome binding site; other site
323097002229	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
323097002230	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
323097002231	ATP binding site [chemical binding]; other site
323097002232	Mg++ binding site [ion binding]; other site
323097002233	motif III; other site
323097002234	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097002235	nucleotide binding region [chemical binding]; other site
323097002236	ATP-binding site [chemical binding]; other site
323097002237	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
323097002238	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
323097002239	active site
323097002240	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
323097002241	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
323097002242	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
323097002243	intracellular septation protein A; Reviewed; Region: PRK00259
323097002244	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
323097002245	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
323097002246	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
323097002247	aconitate hydratase; Validated; Region: PRK09277
323097002248	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
323097002249	substrate binding site [chemical binding]; other site
323097002250	ligand binding site [chemical binding]; other site
323097002251	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
323097002252	substrate binding site [chemical binding]; other site
323097002253	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
323097002254	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097002255	Walker A/P-loop; other site
323097002256	ATP binding site [chemical binding]; other site
323097002257	Q-loop/lid; other site
323097002258	ABC transporter signature motif; other site
323097002259	Walker B; other site
323097002260	D-loop; other site
323097002261	H-loop/switch region; other site
323097002262	heme exporter protein CcmB; Region: ccmB; TIGR01190
323097002263	heme exporter protein CcmC; Region: ccmC; TIGR01191
323097002264	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
323097002265	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323097002266	catalytic residues [active]
323097002267	central insert; other site
323097002268	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
323097002269	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097002270	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
323097002271	putative ADP-binding pocket [chemical binding]; other site
323097002272	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
323097002273	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323097002274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097002275	Walker A/P-loop; other site
323097002276	ATP binding site [chemical binding]; other site
323097002277	Q-loop/lid; other site
323097002278	ABC transporter signature motif; other site
323097002279	Walker B; other site
323097002280	D-loop; other site
323097002281	H-loop/switch region; other site
323097002282	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
323097002283	Protein of unknown function, DUF608; Region: DUF608; pfam04685
323097002284	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
323097002285	PRC-barrel domain; Region: PRC; pfam05239
323097002286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097002287	Major Facilitator Superfamily; Region: MFS_1; pfam07690
323097002288	putative substrate translocation pore; other site
323097002289	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
323097002290	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
323097002291	active site
323097002292	FMN binding site [chemical binding]; other site
323097002293	substrate binding site [chemical binding]; other site
323097002294	3Fe-4S cluster binding site [ion binding]; other site
323097002295	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323097002296	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
323097002297	Creatinine amidohydrolase; Region: Creatininase; pfam02633
323097002298	NMT1/THI5 like; Region: NMT1; pfam09084
323097002299	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
323097002300	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
323097002301	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
323097002302	Walker A/P-loop; other site
323097002303	ATP binding site [chemical binding]; other site
323097002304	Q-loop/lid; other site
323097002305	ABC transporter signature motif; other site
323097002306	Walker B; other site
323097002307	D-loop; other site
323097002308	H-loop/switch region; other site
323097002309	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
323097002310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
323097002311	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
323097002312	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
323097002313	putative ligand binding site [chemical binding]; other site
323097002314	NAD binding site [chemical binding]; other site
323097002315	catalytic site [active]
323097002316	hypothetical protein; Reviewed; Region: PRK00024
323097002317	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
323097002318	MPN+ (JAMM) motif; other site
323097002319	Zinc-binding site [ion binding]; other site
323097002320	methionine aminopeptidase; Provisional; Region: PRK12318
323097002321	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
323097002322	active site
323097002323	potassium/proton antiporter; Reviewed; Region: PRK05326
323097002324	Transporter associated domain; Region: CorC_HlyC; smart01091
323097002325	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097002326	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
323097002327	Walker A/P-loop; other site
323097002328	ATP binding site [chemical binding]; other site
323097002329	Q-loop/lid; other site
323097002330	ABC transporter signature motif; other site
323097002331	Walker B; other site
323097002332	D-loop; other site
323097002333	H-loop/switch region; other site
323097002334	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
323097002335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097002336	dimer interface [polypeptide binding]; other site
323097002337	conserved gate region; other site
323097002338	putative PBP binding loops; other site
323097002339	ABC-ATPase subunit interface; other site
323097002340	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
323097002341	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
323097002342	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
323097002343	GTP-binding protein LepA; Provisional; Region: PRK05433
323097002344	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
323097002345	G1 box; other site
323097002346	putative GEF interaction site [polypeptide binding]; other site
323097002347	GTP/Mg2+ binding site [chemical binding]; other site
323097002348	Switch I region; other site
323097002349	G2 box; other site
323097002350	G3 box; other site
323097002351	Switch II region; other site
323097002352	G4 box; other site
323097002353	G5 box; other site
323097002354	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
323097002355	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
323097002356	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
323097002357	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
323097002358	dimerization domain swap beta strand [polypeptide binding]; other site
323097002359	regulatory protein interface [polypeptide binding]; other site
323097002360	active site
323097002361	regulatory phosphorylation site [posttranslational modification]; other site
323097002362	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
323097002363	active pocket/dimerization site; other site
323097002364	active site
323097002365	phosphorylation site [posttranslational modification]
323097002366	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
323097002367	Hpr binding site; other site
323097002368	active site
323097002369	homohexamer subunit interaction site [polypeptide binding]; other site
323097002370	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
323097002371	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
323097002372	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097002373	HAMP domain; Region: HAMP; pfam00672
323097002374	dimerization interface [polypeptide binding]; other site
323097002375	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097002376	dimer interface [polypeptide binding]; other site
323097002377	phosphorylation site [posttranslational modification]
323097002378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097002379	ATP binding site [chemical binding]; other site
323097002380	Mg2+ binding site [ion binding]; other site
323097002381	G-X-G motif; other site
323097002382	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097002383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097002384	active site
323097002385	phosphorylation site [posttranslational modification]
323097002386	intermolecular recognition site; other site
323097002387	dimerization interface [polypeptide binding]; other site
323097002388	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097002389	DNA binding site [nucleotide binding]
323097002390	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
323097002391	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
323097002392	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
323097002393	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
323097002394	active site
323097002395	substrate-binding site [chemical binding]; other site
323097002396	metal-binding site [ion binding]
323097002397	ATP binding site [chemical binding]; other site
323097002398	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
323097002399	agmatinase; Region: agmatinase; TIGR01230
323097002400	Arginase family; Region: Arginase; cd09989
323097002401	active site
323097002402	Mn binding site [ion binding]; other site
323097002403	oligomer interface [polypeptide binding]; other site
323097002404	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
323097002405	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
323097002406	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
323097002407	active site
323097002408	DNA binding site [nucleotide binding]
323097002409	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
323097002410	DNA binding site [nucleotide binding]
323097002411	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
323097002412	nucleotide binding site [chemical binding]; other site
323097002413	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
323097002414	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
323097002415	putative DNA binding site [nucleotide binding]; other site
323097002416	putative homodimer interface [polypeptide binding]; other site
323097002417	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323097002418	active site
323097002419	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
323097002420	5'-3' exonuclease; Region: 53EXOc; smart00475
323097002421	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
323097002422	active site
323097002423	metal binding site 1 [ion binding]; metal-binding site
323097002424	putative 5' ssDNA interaction site; other site
323097002425	metal binding site 3; metal-binding site
323097002426	metal binding site 2 [ion binding]; metal-binding site
323097002427	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
323097002428	putative DNA binding site [nucleotide binding]; other site
323097002429	putative metal binding site [ion binding]; other site
323097002430	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
323097002431	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
323097002432	active site
323097002433	substrate binding site [chemical binding]; other site
323097002434	catalytic site [active]
323097002435	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
323097002436	active site
323097002437	DNA binding site [nucleotide binding]
323097002438	catalytic site [active]
323097002439	Predicted membrane protein [Function unknown]; Region: COG4763
323097002440	Acyltransferase family; Region: Acyl_transf_3; pfam01757
323097002441	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
323097002442	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097002443	ATP binding site [chemical binding]; other site
323097002444	putative Mg++ binding site [ion binding]; other site
323097002445	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097002446	nucleotide binding region [chemical binding]; other site
323097002447	ATP-binding site [chemical binding]; other site
323097002448	Helicase associated domain (HA2); Region: HA2; pfam04408
323097002449	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
323097002450	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
323097002451	MgtC family; Region: MgtC; pfam02308
323097002452	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
323097002453	catalytic motif [active]
323097002454	Catalytic residue [active]
323097002455	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
323097002456	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
323097002457	active site
323097002458	substrate binding site [chemical binding]; other site
323097002459	metal binding site [ion binding]; metal-binding site
323097002460	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
323097002461	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097002462	putative DNA binding site [nucleotide binding]; other site
323097002463	putative Zn2+ binding site [ion binding]; other site
323097002464	AsnC family; Region: AsnC_trans_reg; pfam01037
323097002465	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
323097002466	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
323097002467	substrate binding site [chemical binding]; other site
323097002468	ATP binding site [chemical binding]; other site
323097002469	HIT domain; Region: HIT; pfam01230
323097002470	HIT family signature motif; other site
323097002471	catalytic residue [active]
323097002472	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
323097002473	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097002474	Walker A motif; other site
323097002475	ATP binding site [chemical binding]; other site
323097002476	Walker B motif; other site
323097002477	arginine finger; other site
323097002478	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
323097002479	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
323097002480	hypothetical protein; Validated; Region: PRK00153
323097002481	recombination protein RecR; Reviewed; Region: recR; PRK00076
323097002482	RecR protein; Region: RecR; pfam02132
323097002483	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
323097002484	tetramer interface [polypeptide binding]; other site
323097002485	putative active site [active]
323097002486	putative metal-binding site [ion binding]; other site
323097002487	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
323097002488	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
323097002489	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323097002490	Methyltransferase domain; Region: Methyltransf_11; pfam08241
323097002491	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
323097002492	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
323097002493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097002494	S-adenosylmethionine binding site [chemical binding]; other site
323097002495	peptide chain release factor 1; Validated; Region: prfA; PRK00591
323097002496	This domain is found in peptide chain release factors; Region: PCRF; smart00937
323097002497	RF-1 domain; Region: RF-1; pfam00472
323097002498	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
323097002499	GAF domain; Region: GAF; pfam01590
323097002500	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
323097002501	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
323097002502	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
323097002503	aspartate kinase; Reviewed; Region: PRK06635
323097002504	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
323097002505	putative nucleotide binding site [chemical binding]; other site
323097002506	putative catalytic residues [active]
323097002507	putative Mg ion binding site [ion binding]; other site
323097002508	putative aspartate binding site [chemical binding]; other site
323097002509	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
323097002510	putative allosteric regulatory site; other site
323097002511	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
323097002512	putative allosteric regulatory residue; other site
323097002513	Bacterial PH domain; Region: DUF304; pfam03703
323097002514	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
323097002515	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097002516	S-adenosylmethionine binding site [chemical binding]; other site
323097002517	Predicted membrane protein [Function unknown]; Region: COG2510
323097002518	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
323097002519	Protein of unknown function (DUF1178); Region: DUF1178; cl17833
323097002520	nitrilase; Region: PLN02798
323097002521	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
323097002522	putative active site [active]
323097002523	catalytic triad [active]
323097002524	dimer interface [polypeptide binding]; other site
323097002525	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
323097002526	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323097002527	active site
323097002528	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323097002529	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
323097002530	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
323097002531	active site
323097002532	8-oxo-dGMP binding site [chemical binding]; other site
323097002533	nudix motif; other site
323097002534	metal binding site [ion binding]; metal-binding site
323097002535	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
323097002536	heterotetramer interface [polypeptide binding]; other site
323097002537	active site pocket [active]
323097002538	cleavage site
323097002539	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
323097002540	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
323097002541	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
323097002542	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
323097002543	ATP binding site [chemical binding]; other site
323097002544	putative Mg++ binding site [ion binding]; other site
323097002545	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
323097002546	SEC-C motif; Region: SEC-C; pfam02810
323097002547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
323097002548	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
323097002549	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
323097002550	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
323097002551	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097002552	active site
323097002553	DNA binding site [nucleotide binding]
323097002554	Int/Topo IB signature motif; other site
323097002555	shikimate kinase; Provisional; Region: PRK13946
323097002556	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
323097002557	ADP binding site [chemical binding]; other site
323097002558	magnesium binding site [ion binding]; other site
323097002559	putative shikimate binding site; other site
323097002560	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
323097002561	active site
323097002562	dimer interface [polypeptide binding]; other site
323097002563	metal binding site [ion binding]; metal-binding site
323097002564	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
323097002565	Domain of unknown function DUF21; Region: DUF21; pfam01595
323097002566	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
323097002567	Transporter associated domain; Region: CorC_HlyC; smart01091
323097002568	PilZ domain; Region: PilZ; pfam07238
323097002569	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
323097002570	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
323097002571	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
323097002572	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
323097002573	HSP70 interaction site [polypeptide binding]; other site
323097002574	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
323097002575	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
323097002576	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
323097002577	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
323097002578	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
323097002579	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
323097002580	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
323097002581	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
323097002582	metal ion-dependent adhesion site (MIDAS); other site
323097002583	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
323097002584	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
323097002585	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
323097002586	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
323097002587	nucleophile elbow; other site
323097002588	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
323097002589	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
323097002590	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097002591	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
323097002592	ATP binding site [chemical binding]; other site
323097002593	putative Mg++ binding site [ion binding]; other site
323097002594	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097002595	nucleotide binding region [chemical binding]; other site
323097002596	ATP-binding site [chemical binding]; other site
323097002597	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323097002598	RNA binding surface [nucleotide binding]; other site
323097002599	Ferredoxin [Energy production and conversion]; Region: COG1146
323097002600	4Fe-4S binding domain; Region: Fer4; cl02805
323097002601	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
323097002602	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
323097002603	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
323097002604	Peptidase family M48; Region: Peptidase_M48; pfam01435
323097002605	Predicted membrane protein [Function unknown]; Region: COG2261
323097002606	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
323097002607	Transposase domain (DUF772); Region: DUF772; pfam05598
323097002608	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097002609	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097002610	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
323097002611	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
323097002612	nucleotide binding site [chemical binding]; other site
323097002613	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
323097002614	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
323097002615	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
323097002616	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
323097002617	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
323097002618	GTPase CgtA; Reviewed; Region: obgE; PRK12299
323097002619	GTP1/OBG; Region: GTP1_OBG; pfam01018
323097002620	Obg GTPase; Region: Obg; cd01898
323097002621	G1 box; other site
323097002622	GTP/Mg2+ binding site [chemical binding]; other site
323097002623	Switch I region; other site
323097002624	G2 box; other site
323097002625	G3 box; other site
323097002626	Switch II region; other site
323097002627	G4 box; other site
323097002628	G5 box; other site
323097002629	gamma-glutamyl kinase; Provisional; Region: PRK05429
323097002630	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
323097002631	nucleotide binding site [chemical binding]; other site
323097002632	homotetrameric interface [polypeptide binding]; other site
323097002633	putative phosphate binding site [ion binding]; other site
323097002634	putative allosteric binding site; other site
323097002635	PUA domain; Region: PUA; pfam01472
323097002636	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
323097002637	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
323097002638	putative catalytic cysteine [active]
323097002639	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
323097002640	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
323097002641	active site
323097002642	(T/H)XGH motif; other site
323097002643	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
323097002644	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
323097002645	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
323097002646	Peptidase family M23; Region: Peptidase_M23; pfam01551
323097002647	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
323097002648	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
323097002649	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
323097002650	protein binding site [polypeptide binding]; other site
323097002651	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
323097002652	Catalytic dyad [active]
323097002653	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
323097002654	putative active site [active]
323097002655	NodB motif; other site
323097002656	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
323097002657	putative active site [active]
323097002658	Ap4A binding site [chemical binding]; other site
323097002659	nudix motif; other site
323097002660	putative metal binding site [ion binding]; other site
323097002661	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13448
323097002662	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
323097002663	gamma subunit interface [polypeptide binding]; other site
323097002664	epsilon subunit interface [polypeptide binding]; other site
323097002665	LBP interface [polypeptide binding]; other site
323097002666	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
323097002667	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
323097002668	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
323097002669	alpha subunit interaction interface [polypeptide binding]; other site
323097002670	Walker A motif; other site
323097002671	ATP binding site [chemical binding]; other site
323097002672	Walker B motif; other site
323097002673	inhibitor binding site; inhibition site
323097002674	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
323097002675	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
323097002676	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
323097002677	core domain interface [polypeptide binding]; other site
323097002678	delta subunit interface [polypeptide binding]; other site
323097002679	epsilon subunit interface [polypeptide binding]; other site
323097002680	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
323097002681	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
323097002682	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
323097002683	beta subunit interaction interface [polypeptide binding]; other site
323097002684	Walker A motif; other site
323097002685	ATP binding site [chemical binding]; other site
323097002686	Walker B motif; other site
323097002687	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
323097002688	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
323097002689	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
323097002690	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
323097002691	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
323097002692	primosome assembly protein PriA; Validated; Region: PRK05580
323097002693	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097002694	ATP binding site [chemical binding]; other site
323097002695	putative Mg++ binding site [ion binding]; other site
323097002696	helicase superfamily c-terminal domain; Region: HELICc; smart00490
323097002697	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
323097002698	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097002699	active site
323097002700	DNA binding site [nucleotide binding]
323097002701	Int/Topo IB signature motif; other site
323097002702	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
323097002703	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097002704	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323097002705	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
323097002706	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
323097002707	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
323097002708	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323097002709	E3 interaction surface; other site
323097002710	lipoyl attachment site [posttranslational modification]; other site
323097002711	e3 binding domain; Region: E3_binding; pfam02817
323097002712	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
323097002713	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
323097002714	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
323097002715	TPP-binding site [chemical binding]; other site
323097002716	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
323097002717	dimer interface [polypeptide binding]; other site
323097002718	PYR/PP interface [polypeptide binding]; other site
323097002719	TPP binding site [chemical binding]; other site
323097002720	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
323097002721	CoA binding domain; Region: CoA_binding; smart00881
323097002722	CoA-ligase; Region: Ligase_CoA; pfam00549
323097002723	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
323097002724	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
323097002725	CoA-ligase; Region: Ligase_CoA; pfam00549
323097002726	malate dehydrogenase; Reviewed; Region: PRK06223
323097002727	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
323097002728	NAD(P) binding site [chemical binding]; other site
323097002729	dimer interface [polypeptide binding]; other site
323097002730	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323097002731	substrate binding site [chemical binding]; other site
323097002732	Predicted ATPase [General function prediction only]; Region: COG1485
323097002733	AAA ATPase domain; Region: AAA_16; pfam13191
323097002734	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
323097002735	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
323097002736	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
323097002737	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
323097002738	active site
323097002739	oxyanion hole [active]
323097002740	switch loop; other site
323097002741	catalytic triad [active]
323097002742	ABC transporter; Region: ABC_tran; pfam00005
323097002743	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
323097002744	Q-loop/lid; other site
323097002745	ABC transporter signature motif; other site
323097002746	Walker B; other site
323097002747	D-loop; other site
323097002748	H-loop/switch region; other site
323097002749	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
323097002750	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
323097002751	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
323097002752	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
323097002753	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
323097002754	ATP-dependent DNA ligase; Validated; Region: PRK09247
323097002755	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
323097002756	active site
323097002757	DNA binding site [nucleotide binding]
323097002758	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
323097002759	DNA binding site [nucleotide binding]
323097002760	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
323097002761	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
323097002762	quinone interaction residues [chemical binding]; other site
323097002763	active site
323097002764	catalytic residues [active]
323097002765	FMN binding site [chemical binding]; other site
323097002766	substrate binding site [chemical binding]; other site
323097002767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
323097002768	Predicted transcriptional regulator [Transcription]; Region: COG2932
323097002769	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
323097002770	Catalytic site [active]
323097002771	acetyl-CoA synthetase; Provisional; Region: PRK00174
323097002772	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
323097002773	active site
323097002774	CoA binding site [chemical binding]; other site
323097002775	acyl-activating enzyme (AAE) consensus motif; other site
323097002776	AMP binding site [chemical binding]; other site
323097002777	acetate binding site [chemical binding]; other site
323097002778	EVE domain; Region: EVE; pfam01878
323097002779	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
323097002780	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
323097002781	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
323097002782	UGMP family protein; Validated; Region: PRK09604
323097002783	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
323097002784	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
323097002785	domain interfaces; other site
323097002786	active site
323097002787	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
323097002788	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
323097002789	active site
323097002790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
323097002791	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
323097002792	HemY protein N-terminus; Region: HemY_N; pfam07219
323097002793	YcfA-like protein; Region: YcfA; pfam07927
323097002794	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
323097002795	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
323097002796	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097002797	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323097002798	catalytic residues [active]
323097002799	catalytic nucleophile [active]
323097002800	Recombinase; Region: Recombinase; pfam07508
323097002801	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323097002802	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
323097002803	DNA methylase; Region: N6_N4_Mtase; cl17433
323097002804	Helix-turn-helix domain; Region: HTH_36; pfam13730
323097002805	ParA-like protein; Provisional; Region: PHA02518
323097002806	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097002807	P-loop; other site
323097002808	Magnesium ion binding site [ion binding]; other site
323097002809	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
323097002810	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
323097002811	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
323097002812	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
323097002813	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097002814	sequence-specific DNA binding site [nucleotide binding]; other site
323097002815	salt bridge; other site
323097002816	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
323097002817	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097002818	non-specific DNA binding site [nucleotide binding]; other site
323097002819	salt bridge; other site
323097002820	sequence-specific DNA binding site [nucleotide binding]; other site
323097002821	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
323097002822	putative active site [active]
323097002823	catalytic site [active]
323097002824	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
323097002825	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097002826	ATP binding site [chemical binding]; other site
323097002827	putative Mg++ binding site [ion binding]; other site
323097002828	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097002829	nucleotide binding region [chemical binding]; other site
323097002830	ATP-binding site [chemical binding]; other site
323097002831	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
323097002832	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
323097002833	DNA methylase; Region: N6_N4_Mtase; cl17433
323097002834	DNA methylase; Region: N6_N4_Mtase; pfam01555
323097002835	DNA methylase; Region: N6_N4_Mtase; pfam01555
323097002836	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097002837	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
323097002838	catalytic residues [active]
323097002839	catalytic nucleophile [active]
323097002840	Presynaptic Site I dimer interface [polypeptide binding]; other site
323097002841	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
323097002842	Synaptic Flat tetramer interface [polypeptide binding]; other site
323097002843	Synaptic Site I dimer interface [polypeptide binding]; other site
323097002844	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
323097002845	DNA-binding interface [nucleotide binding]; DNA binding site
323097002846	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
323097002847	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
323097002848	HSP70 interaction site [polypeptide binding]; other site
323097002849	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
323097002850	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323097002851	Walker A motif; other site
323097002852	ATP binding site [chemical binding]; other site
323097002853	Walker B motif; other site
323097002854	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
323097002855	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
323097002856	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
323097002857	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
323097002858	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
323097002859	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
323097002860	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
323097002861	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
323097002862	putative metal binding site [ion binding]; other site
323097002863	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
323097002864	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097002865	NAD(P) binding site [chemical binding]; other site
323097002866	active site
323097002867	YGGT family; Region: YGGT; pfam02325
323097002868	hypothetical protein; Validated; Region: PRK01310
323097002869	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
323097002870	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
323097002871	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
323097002872	homodimer interface [polypeptide binding]; other site
323097002873	NADP binding site [chemical binding]; other site
323097002874	substrate binding site [chemical binding]; other site
323097002875	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
323097002876	dimer interface [polypeptide binding]; other site
323097002877	substrate binding site [chemical binding]; other site
323097002878	metal binding sites [ion binding]; metal-binding site
323097002879	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323097002880	Coenzyme A binding pocket [chemical binding]; other site
323097002881	Isochorismatase family; Region: Isochorismatase; pfam00857
323097002882	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
323097002883	catalytic triad [active]
323097002884	conserved cis-peptide bond; other site
323097002885	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097002886	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
323097002887	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
323097002888	MutS domain I; Region: MutS_I; pfam01624
323097002889	MutS domain II; Region: MutS_II; pfam05188
323097002890	MutS domain III; Region: MutS_III; pfam05192
323097002891	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
323097002892	Walker A/P-loop; other site
323097002893	ATP binding site [chemical binding]; other site
323097002894	Q-loop/lid; other site
323097002895	ABC transporter signature motif; other site
323097002896	Walker B; other site
323097002897	D-loop; other site
323097002898	H-loop/switch region; other site
323097002899	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
323097002900	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097002901	putative substrate translocation pore; other site
323097002902	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
323097002903	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097002904	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097002905	Transcriptional regulators [Transcription]; Region: MarR; COG1846
323097002906	MarR family; Region: MarR; pfam01047
323097002907	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
323097002908	metal binding site 2 [ion binding]; metal-binding site
323097002909	putative DNA binding helix; other site
323097002910	metal binding site 1 [ion binding]; metal-binding site
323097002911	dimer interface [polypeptide binding]; other site
323097002912	structural Zn2+ binding site [ion binding]; other site
323097002913	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
323097002914	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
323097002915	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
323097002916	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
323097002917	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
323097002918	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
323097002919	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
323097002920	substrate binding pocket [chemical binding]; other site
323097002921	chain length determination region; other site
323097002922	substrate-Mg2+ binding site; other site
323097002923	catalytic residues [active]
323097002924	aspartate-rich region 1; other site
323097002925	active site lid residues [active]
323097002926	aspartate-rich region 2; other site
323097002927	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
323097002928	Transglycosylase; Region: Transgly; cl17702
323097002929	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
323097002930	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323097002931	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323097002932	metal binding site [ion binding]; metal-binding site
323097002933	active site
323097002934	I-site; other site
323097002935	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323097002936	Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534
323097002937	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
323097002938	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
323097002939	putative active site [active]
323097002940	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323097002941	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
323097002942	ligand binding site [chemical binding]; other site
323097002943	Predicted integral membrane protein [Function unknown]; Region: COG0392
323097002944	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323097002945	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097002946	dimer interface [polypeptide binding]; other site
323097002947	phosphorylation site [posttranslational modification]
323097002948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097002949	ATP binding site [chemical binding]; other site
323097002950	Mg2+ binding site [ion binding]; other site
323097002951	G-X-G motif; other site
323097002952	PBP superfamily domain; Region: PBP_like_2; cl17296
323097002953	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097002954	dimer interface [polypeptide binding]; other site
323097002955	conserved gate region; other site
323097002956	putative PBP binding loops; other site
323097002957	ABC-ATPase subunit interface; other site
323097002958	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
323097002959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097002960	dimer interface [polypeptide binding]; other site
323097002961	conserved gate region; other site
323097002962	putative PBP binding loops; other site
323097002963	ABC-ATPase subunit interface; other site
323097002964	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
323097002965	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
323097002966	Walker A/P-loop; other site
323097002967	ATP binding site [chemical binding]; other site
323097002968	Q-loop/lid; other site
323097002969	ABC transporter signature motif; other site
323097002970	Walker B; other site
323097002971	D-loop; other site
323097002972	H-loop/switch region; other site
323097002973	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
323097002974	PhoU domain; Region: PhoU; pfam01895
323097002975	PhoU domain; Region: PhoU; pfam01895
323097002976	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
323097002977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097002978	active site
323097002979	phosphorylation site [posttranslational modification]
323097002980	intermolecular recognition site; other site
323097002981	dimerization interface [polypeptide binding]; other site
323097002982	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097002983	DNA binding site [nucleotide binding]
323097002984	GcrA cell cycle regulator; Region: GcrA; pfam07750
323097002985	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
323097002986	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
323097002987	inhibitor-cofactor binding pocket; inhibition site
323097002988	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097002989	catalytic residue [active]
323097002990	ornithine carbamoyltransferase; Provisional; Region: PRK00779
323097002991	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
323097002992	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
323097002993	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
323097002994	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
323097002995	G1 box; other site
323097002996	putative GEF interaction site [polypeptide binding]; other site
323097002997	GTP/Mg2+ binding site [chemical binding]; other site
323097002998	Switch I region; other site
323097002999	G2 box; other site
323097003000	G3 box; other site
323097003001	Switch II region; other site
323097003002	G4 box; other site
323097003003	G5 box; other site
323097003004	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
323097003005	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
323097003006	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323097003007	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
323097003008	Response regulator receiver domain; Region: Response_reg; pfam00072
323097003009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097003010	active site
323097003011	phosphorylation site [posttranslational modification]
323097003012	intermolecular recognition site; other site
323097003013	dimerization interface [polypeptide binding]; other site
323097003014	NnrS protein; Region: NnrS; pfam05940
323097003015	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
323097003016	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442
323097003017	Cytochrome c; Region: Cytochrom_C; cl11414
323097003018	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
323097003019	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323097003020	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323097003021	ligand binding site [chemical binding]; other site
323097003022	flexible hinge region; other site
323097003023	putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312
323097003024	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
323097003025	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097003026	NAD(P) binding site [chemical binding]; other site
323097003027	active site
323097003028	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
323097003029	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
323097003030	DNA binding site [nucleotide binding]
323097003031	sequence specific DNA binding site [nucleotide binding]; other site
323097003032	putative cAMP binding site [chemical binding]; other site
323097003033	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
323097003034	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
323097003035	MOFRL family; Region: MOFRL; pfam05161
323097003036	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
323097003037	Peptidase family M23; Region: Peptidase_M23; pfam01551
323097003038	AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478
323097003039	[2Fe-2S] cluster binding site [ion binding]; other site
323097003040	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
323097003041	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323097003042	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
323097003043	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
323097003044	active site
323097003045	DNA binding site [nucleotide binding]
323097003046	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
323097003047	Response regulator receiver domain; Region: Response_reg; pfam00072
323097003048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097003049	active site
323097003050	phosphorylation site [posttranslational modification]
323097003051	intermolecular recognition site; other site
323097003052	dimerization interface [polypeptide binding]; other site
323097003053	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
323097003054	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
323097003055	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
323097003056	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097003057	Walker A/P-loop; other site
323097003058	ATP binding site [chemical binding]; other site
323097003059	Q-loop/lid; other site
323097003060	ABC transporter signature motif; other site
323097003061	Walker B; other site
323097003062	D-loop; other site
323097003063	H-loop/switch region; other site
323097003064	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
323097003065	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
323097003066	Uncharacterized conserved protein [Function unknown]; Region: COG1434
323097003067	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
323097003068	putative active site [active]
323097003069	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
323097003070	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
323097003071	putative acyl-acceptor binding pocket; other site
323097003072	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
323097003073	putative active site pocket [active]
323097003074	dimerization interface [polypeptide binding]; other site
323097003075	putative catalytic residue [active]
323097003076	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
323097003077	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
323097003078	prephenate dehydrogenase; Validated; Region: PRK08507
323097003079	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
323097003080	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323097003081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097003082	homodimer interface [polypeptide binding]; other site
323097003083	catalytic residue [active]
323097003084	hypothetical protein; Provisional; Region: PRK06034
323097003085	Chorismate mutase type II; Region: CM_2; pfam01817
323097003086	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
323097003087	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
323097003088	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323097003089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097003090	S-adenosylmethionine binding site [chemical binding]; other site
323097003091	TIGR02594 family protein; Region: TIGR02594
323097003092	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
323097003093	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
323097003094	MOSC domain; Region: MOSC; pfam03473
323097003095	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
323097003096	Clp amino terminal domain; Region: Clp_N; pfam02861
323097003097	Clp amino terminal domain; Region: Clp_N; pfam02861
323097003098	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097003099	Walker A motif; other site
323097003100	ATP binding site [chemical binding]; other site
323097003101	Walker B motif; other site
323097003102	arginine finger; other site
323097003103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097003104	Walker A motif; other site
323097003105	ATP binding site [chemical binding]; other site
323097003106	Walker B motif; other site
323097003107	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
323097003108	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
323097003109	Flavodoxin; Region: Flavodoxin_1; pfam00258
323097003110	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
323097003111	FAD binding pocket [chemical binding]; other site
323097003112	FAD binding motif [chemical binding]; other site
323097003113	catalytic residues [active]
323097003114	NAD binding pocket [chemical binding]; other site
323097003115	phosphate binding motif [ion binding]; other site
323097003116	beta-alpha-beta structure motif; other site
323097003117	sulfite reductase subunit beta; Provisional; Region: PRK13504
323097003118	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
323097003119	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
323097003120	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
323097003121	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
323097003122	homodimer interface [polypeptide binding]; other site
323097003123	substrate-cofactor binding pocket; other site
323097003124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097003125	catalytic residue [active]
323097003126	BA14K-like protein; Region: BA14K; pfam07886
323097003127	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
323097003128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097003129	Walker A motif; other site
323097003130	ATP binding site [chemical binding]; other site
323097003131	Walker B motif; other site
323097003132	Family description; Region: UvrD_C_2; pfam13538
323097003133	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
323097003134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097003135	Walker A motif; other site
323097003136	ATP binding site [chemical binding]; other site
323097003137	Walker B motif; other site
323097003138	arginine finger; other site
323097003139	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
323097003140	flagellar motor switch protein; Reviewed; Region: PRK08916
323097003141	flagellar assembly protein H; Validated; Region: fliH; PRK06032
323097003142	Flagellar assembly protein FliH; Region: FliH; pfam02108
323097003143	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
323097003144	MgtE intracellular N domain; Region: MgtE_N; cl15244
323097003145	FliG C-terminal domain; Region: FliG_C; pfam01706
323097003146	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
323097003147	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
323097003148	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
323097003149	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
323097003150	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
323097003151	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
323097003152	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
323097003153	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
323097003154	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
323097003155	Ligand Binding Site [chemical binding]; other site
323097003156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
323097003157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097003158	S-adenosylmethionine binding site [chemical binding]; other site
323097003159	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
323097003160	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
323097003161	putative acyl-acceptor binding pocket; other site
323097003162	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
323097003163	Transposase domain (DUF772); Region: DUF772; pfam05598
323097003164	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097003165	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097003166	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
323097003167	Putative ParB-like nuclease; Region: ParBc_2; cl17538
323097003168	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
323097003169	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
323097003170	Sulfate transporter family; Region: Sulfate_transp; pfam00916
323097003171	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
323097003172	SnoaL-like domain; Region: SnoaL_2; pfam12680
323097003173	Predicted membrane protein [Function unknown]; Region: COG2259
323097003174	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
323097003175	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
323097003176	FMN binding site [chemical binding]; other site
323097003177	active site
323097003178	substrate binding site [chemical binding]; other site
323097003179	catalytic residue [active]
323097003180	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323097003181	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097003182	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097003183	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
323097003184	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323097003185	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
323097003186	Coenzyme A binding pocket [chemical binding]; other site
323097003187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097003188	metabolite-proton symporter; Region: 2A0106; TIGR00883
323097003189	putative substrate translocation pore; other site
323097003190	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323097003191	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323097003192	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323097003193	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097003194	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
323097003195	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
323097003196	Walker A/P-loop; other site
323097003197	ATP binding site [chemical binding]; other site
323097003198	Q-loop/lid; other site
323097003199	ABC transporter signature motif; other site
323097003200	Walker B; other site
323097003201	D-loop; other site
323097003202	H-loop/switch region; other site
323097003203	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
323097003204	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
323097003205	Homeodomain-like domain; Region: HTH_23; pfam13384
323097003206	Cupin domain; Region: Cupin_2; cl17218
323097003207	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
323097003208	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
323097003209	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
323097003210	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
323097003211	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
323097003212	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
323097003213	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
323097003214	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323097003215	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
323097003216	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
323097003217	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
323097003218	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
323097003219	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
323097003220	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
323097003221	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
323097003222	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
323097003223	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
323097003224	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
323097003225	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
323097003226	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
323097003227	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
323097003228	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
323097003229	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
323097003230	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323097003231	Walker A motif; other site
323097003232	ATP binding site [chemical binding]; other site
323097003233	Walker B motif; other site
323097003234	type II secretion system protein D; Region: type_II_gspD; TIGR02517
323097003235	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
323097003236	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
323097003237	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
323097003238	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
323097003239	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323097003240	Sel1-like repeats; Region: SEL1; smart00671
323097003241	Sel1-like repeats; Region: SEL1; smart00671
323097003242	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
323097003243	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
323097003244	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
323097003245	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
323097003246	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323097003247	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097003248	N-terminal plug; other site
323097003249	ligand-binding site [chemical binding]; other site
323097003250	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323097003251	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
323097003252	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323097003253	Gram-negative bacterial tonB protein; Region: TonB; cl10048
323097003254	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
323097003255	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
323097003256	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
323097003257	TrkA-N domain; Region: TrkA_N; pfam02254
323097003258	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
323097003259	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
323097003260	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
323097003261	dimerization interface [polypeptide binding]; other site
323097003262	active site
323097003263	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
323097003264	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323097003265	FAD binding site [chemical binding]; other site
323097003266	substrate binding pocket [chemical binding]; other site
323097003267	catalytic base [active]
323097003268	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
323097003269	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
323097003270	LysR family transcriptional regulator; Provisional; Region: PRK14997
323097003271	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097003272	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
323097003273	putative effector binding pocket; other site
323097003274	putative dimerization interface [polypeptide binding]; other site
323097003275	Pirin-related protein [General function prediction only]; Region: COG1741
323097003276	Pirin; Region: Pirin; pfam02678
323097003277	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
323097003278	putative acyl-CoA synthetase; Provisional; Region: PRK06018
323097003279	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
323097003280	dimer interface [polypeptide binding]; other site
323097003281	acyl-activating enzyme (AAE) consensus motif; other site
323097003282	putative active site [active]
323097003283	AMP binding site [chemical binding]; other site
323097003284	putative CoA binding site [chemical binding]; other site
323097003285	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
323097003286	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323097003287	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097003288	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
323097003289	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
323097003290	Cl binding site [ion binding]; other site
323097003291	oligomer interface [polypeptide binding]; other site
323097003292	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
323097003293	classical (c) SDRs; Region: SDR_c; cd05233
323097003294	NAD(P) binding site [chemical binding]; other site
323097003295	active site
323097003296	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
323097003297	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
323097003298	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
323097003299	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
323097003300	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
323097003301	HSP70 interaction site [polypeptide binding]; other site
323097003302	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
323097003303	substrate binding site [polypeptide binding]; other site
323097003304	dimer interface [polypeptide binding]; other site
323097003305	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
323097003306	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323097003307	catalytic core [active]
323097003308	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
323097003309	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
323097003310	Tetramer interface [polypeptide binding]; other site
323097003311	active site
323097003312	FMN-binding site [chemical binding]; other site
323097003313	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
323097003314	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
323097003315	HAMP domain; Region: HAMP; pfam00672
323097003316	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
323097003317	dimer interface [polypeptide binding]; other site
323097003318	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
323097003319	putative CheW interface [polypeptide binding]; other site
323097003320	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097003321	dimerization interface [polypeptide binding]; other site
323097003322	putative DNA binding site [nucleotide binding]; other site
323097003323	putative Zn2+ binding site [ion binding]; other site
323097003324	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
323097003325	TRAM domain; Region: TRAM; cl01282
323097003326	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
323097003327	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323097003328	RNA binding surface [nucleotide binding]; other site
323097003329	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097003330	S-adenosylmethionine binding site [chemical binding]; other site
323097003331	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
323097003332	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
323097003333	TPP-binding site; other site
323097003334	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
323097003335	PYR/PP interface [polypeptide binding]; other site
323097003336	dimer interface [polypeptide binding]; other site
323097003337	TPP binding site [chemical binding]; other site
323097003338	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
323097003339	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
323097003340	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
323097003341	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
323097003342	putative active site [active]
323097003343	Zn binding site [ion binding]; other site
323097003344	enoyl-CoA hydratase; Provisional; Region: PRK06688
323097003345	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
323097003346	substrate binding site [chemical binding]; other site
323097003347	oxyanion hole (OAH) forming residues; other site
323097003348	trimer interface [polypeptide binding]; other site
323097003349	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323097003350	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323097003351	active site
323097003352	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
323097003353	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
323097003354	dimer interface [polypeptide binding]; other site
323097003355	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
323097003356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097003357	Walker A motif; other site
323097003358	ATP binding site [chemical binding]; other site
323097003359	Walker B motif; other site
323097003360	arginine finger; other site
323097003361	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
323097003362	DNA binding residues [nucleotide binding]
323097003363	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
323097003364	Integrase core domain; Region: rve; pfam00665
323097003365	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097003366	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
323097003367	putative active site [active]
323097003368	AAA domain; Region: AAA_33; pfam13671
323097003369	hypothetical protein; Provisional; Region: PRK08356
323097003370	beta-RFAP synthase; Region: beta_RFAP_syn; TIGR00144
323097003371	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
323097003372	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097003373	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
323097003374	catalytic residues [active]
323097003375	catalytic nucleophile [active]
323097003376	Presynaptic Site I dimer interface [polypeptide binding]; other site
323097003377	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
323097003378	Synaptic Flat tetramer interface [polypeptide binding]; other site
323097003379	Synaptic Site I dimer interface [polypeptide binding]; other site
323097003380	DNA binding site [nucleotide binding]
323097003381	Recombinase; Region: Recombinase; pfam07508
323097003382	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
323097003383	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
323097003384	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097003385	salt bridge; other site
323097003386	non-specific DNA binding site [nucleotide binding]; other site
323097003387	sequence-specific DNA binding site [nucleotide binding]; other site
323097003388	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
323097003389	Terminase-like family; Region: Terminase_6; pfam03237
323097003390	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
323097003391	ParB-like nuclease domain; Region: ParBc; pfam02195
323097003392	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
323097003393	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
323097003394	DNA methylase; Region: N6_N4_Mtase; pfam01555
323097003395	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
323097003396	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
323097003397	tetramer interface [polypeptide binding]; other site
323097003398	heme binding pocket [chemical binding]; other site
323097003399	NADPH binding site [chemical binding]; other site
323097003400	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323097003401	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097003402	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097003403	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097003404	Homeodomain-like domain; Region: HTH_23; pfam13384
323097003405	Winged helix-turn helix; Region: HTH_29; pfam13551
323097003406	Homeodomain-like domain; Region: HTH_32; pfam13565
323097003407	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097003408	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097003409	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097003410	DNA-binding site [nucleotide binding]; DNA binding site
323097003411	RNA-binding motif; other site
323097003412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
323097003413	Terminase-like family; Region: Terminase_6; pfam03237
323097003414	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
323097003415	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
323097003416	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
323097003417	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
323097003418	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
323097003419	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
323097003420	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
323097003421	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
323097003422	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097003423	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
323097003424	Walker A motif; other site
323097003425	ATP binding site [chemical binding]; other site
323097003426	Walker B motif; other site
323097003427	arginine finger; other site
323097003428	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
323097003429	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
323097003430	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
323097003431	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
323097003432	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097003433	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097003434	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097003435	Transposase; Region: HTH_Tnp_1; cl17663
323097003436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323097003437	G8 domain; Region: G8; pfam10162
323097003438	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
323097003439	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
323097003440	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
323097003441	tetramer interface [polypeptide binding]; other site
323097003442	heme binding pocket [chemical binding]; other site
323097003443	NADPH binding site [chemical binding]; other site
323097003444	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
323097003445	PLD-like domain; Region: PLDc_2; pfam13091
323097003446	putative active site [active]
323097003447	catalytic site [active]
323097003448	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
323097003449	PLD-like domain; Region: PLDc_2; pfam13091
323097003450	putative active site [active]
323097003451	catalytic site [active]
323097003452	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
323097003453	putative catalytic site [active]
323097003454	putative metal binding site [ion binding]; other site
323097003455	putative phosphate binding site [ion binding]; other site
323097003456	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323097003457	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097003458	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
323097003459	putative effector binding pocket; other site
323097003460	putative dimerization interface [polypeptide binding]; other site
323097003461	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
323097003462	putative active site [active]
323097003463	putative catalytic site [active]
323097003464	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
323097003465	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
323097003466	putative hydrophobic ligand binding site [chemical binding]; other site
323097003467	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
323097003468	putative heme binding pocket [chemical binding]; other site
323097003469	integron integrase; Region: integrase_gron; TIGR02249
323097003470	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
323097003471	Int/Topo IB signature motif; other site
323097003472	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
323097003473	FOG: CBS domain [General function prediction only]; Region: COG0517
323097003474	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
323097003475	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323097003476	Coenzyme A binding pocket [chemical binding]; other site
323097003477	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
323097003478	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
323097003479	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
323097003480	phosphate acetyltransferase; Provisional; Region: PRK11890
323097003481	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
323097003482	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
323097003483	propionate/acetate kinase; Provisional; Region: PRK12379
323097003484	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
323097003485	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
323097003486	NAD binding site [chemical binding]; other site
323097003487	homotetramer interface [polypeptide binding]; other site
323097003488	homodimer interface [polypeptide binding]; other site
323097003489	substrate binding site [chemical binding]; other site
323097003490	active site
323097003491	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
323097003492	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
323097003493	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
323097003494	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323097003495	ligand binding site [chemical binding]; other site
323097003496	flexible hinge region; other site
323097003497	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
323097003498	putative switch regulator; other site
323097003499	non-specific DNA interactions [nucleotide binding]; other site
323097003500	DNA binding site [nucleotide binding]
323097003501	sequence specific DNA binding site [nucleotide binding]; other site
323097003502	putative cAMP binding site [chemical binding]; other site
323097003503	Homeodomain-like domain; Region: HTH_23; pfam13384
323097003504	Winged helix-turn helix; Region: HTH_29; pfam13551
323097003505	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097003506	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097003507	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
323097003508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097003509	active site
323097003510	phosphorylation site [posttranslational modification]
323097003511	intermolecular recognition site; other site
323097003512	dimerization interface [polypeptide binding]; other site
323097003513	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323097003514	DNA binding residues [nucleotide binding]
323097003515	dimerization interface [polypeptide binding]; other site
323097003516	Response regulator receiver domain; Region: Response_reg; pfam00072
323097003517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097003518	active site
323097003519	phosphorylation site [posttranslational modification]
323097003520	intermolecular recognition site; other site
323097003521	dimerization interface [polypeptide binding]; other site
323097003522	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
323097003523	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
323097003524	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
323097003525	Sulfate transporter family; Region: Sulfate_transp; pfam00916
323097003526	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
323097003527	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
323097003528	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
323097003529	Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865
323097003530	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
323097003531	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097003532	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097003533	dimer interface [polypeptide binding]; other site
323097003534	phosphorylation site [posttranslational modification]
323097003535	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097003536	ATP binding site [chemical binding]; other site
323097003537	Mg2+ binding site [ion binding]; other site
323097003538	G-X-G motif; other site
323097003539	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
323097003540	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
323097003541	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
323097003542	Pyruvate formate lyase 1; Region: PFL1; cd01678
323097003543	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
323097003544	coenzyme A binding site [chemical binding]; other site
323097003545	active site
323097003546	catalytic residues [active]
323097003547	glycine loop; other site
323097003548	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
323097003549	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097003550	FeS/SAM binding site; other site
323097003551	Predicted permease [General function prediction only]; Region: COG2985
323097003552	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
323097003553	TrkA-C domain; Region: TrkA_C; pfam02080
323097003554	TrkA-C domain; Region: TrkA_C; pfam02080
323097003555	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
323097003556	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13448
323097003557	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
323097003558	gamma subunit interface [polypeptide binding]; other site
323097003559	epsilon subunit interface [polypeptide binding]; other site
323097003560	LBP interface [polypeptide binding]; other site
323097003561	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
323097003562	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
323097003563	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097003564	Protein of unknown function (DUF3223); Region: DUF3223; pfam11523
323097003565	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
323097003566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097003567	Walker A motif; other site
323097003568	ATP binding site [chemical binding]; other site
323097003569	Walker B motif; other site
323097003570	arginine finger; other site
323097003571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
323097003572	Integrase core domain; Region: rve; pfam00665
323097003573	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323097003574	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
323097003575	FtsX-like permease family; Region: FtsX; pfam02687
323097003576	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
323097003577	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
323097003578	Walker A/P-loop; other site
323097003579	ATP binding site [chemical binding]; other site
323097003580	Q-loop/lid; other site
323097003581	ABC transporter signature motif; other site
323097003582	Walker B; other site
323097003583	D-loop; other site
323097003584	H-loop/switch region; other site
323097003585	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323097003586	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097003587	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097003588	Surface antigen  (SAG) superfamily; Provisional; Region: PTZ00366
323097003589	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
323097003590	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
323097003591	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
323097003592	active site clefts [active]
323097003593	zinc binding site [ion binding]; other site
323097003594	dimer interface [polypeptide binding]; other site
323097003595	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
323097003596	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
323097003597	active site
323097003598	ADP/pyrophosphate binding site [chemical binding]; other site
323097003599	dimerization interface [polypeptide binding]; other site
323097003600	allosteric effector site; other site
323097003601	fructose-1,6-bisphosphate binding site; other site
323097003602	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
323097003603	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
323097003604	dimerization interface [polypeptide binding]; other site
323097003605	DPS ferroxidase diiron center [ion binding]; other site
323097003606	ion pore; other site
323097003607	aconitate hydratase; Validated; Region: PRK09277
323097003608	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
323097003609	substrate binding site [chemical binding]; other site
323097003610	ligand binding site [chemical binding]; other site
323097003611	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
323097003612	substrate binding site [chemical binding]; other site
323097003613	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097003614	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
323097003615	active site
323097003616	metal binding site [ion binding]; metal-binding site
323097003617	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
323097003618	Moco binding site; other site
323097003619	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
323097003620	metal coordination site [ion binding]; other site
323097003621	dimerization interface [polypeptide binding]; other site
323097003622	NnrS protein; Region: NnrS; pfam05940
323097003623	maleylacetoacetate isomerase; Region: maiA; TIGR01262
323097003624	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
323097003625	C-terminal domain interface [polypeptide binding]; other site
323097003626	GSH binding site (G-site) [chemical binding]; other site
323097003627	putative dimer interface [polypeptide binding]; other site
323097003628	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
323097003629	dimer interface [polypeptide binding]; other site
323097003630	N-terminal domain interface [polypeptide binding]; other site
323097003631	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
323097003632	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
323097003633	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
323097003634	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
323097003635	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
323097003636	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323097003637	fumarylacetoacetase; Region: PLN02856
323097003638	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
323097003639	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
323097003640	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
323097003641	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
323097003642	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
323097003643	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
323097003644	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
323097003645	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
323097003646	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
323097003647	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
323097003648	FAD binding pocket [chemical binding]; other site
323097003649	FAD binding motif [chemical binding]; other site
323097003650	phosphate binding motif [ion binding]; other site
323097003651	beta-alpha-beta structure motif; other site
323097003652	NAD(p) ribose binding residues [chemical binding]; other site
323097003653	NAD binding pocket [chemical binding]; other site
323097003654	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
323097003655	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323097003656	catalytic loop [active]
323097003657	iron binding site [ion binding]; other site
323097003658	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
323097003659	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
323097003660	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
323097003661	substrate binding site [chemical binding]; other site
323097003662	dimer interface [polypeptide binding]; other site
323097003663	NADP binding site [chemical binding]; other site
323097003664	catalytic residues [active]
323097003665	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
323097003666	substrate binding site [chemical binding]; other site
323097003667	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323097003668	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323097003669	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
323097003670	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
323097003671	CoenzymeA binding site [chemical binding]; other site
323097003672	subunit interaction site [polypeptide binding]; other site
323097003673	PHB binding site; other site
323097003674	enoyl-CoA hydratase; Provisional; Region: PRK08140
323097003675	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
323097003676	substrate binding site [chemical binding]; other site
323097003677	oxyanion hole (OAH) forming residues; other site
323097003678	trimer interface [polypeptide binding]; other site
323097003679	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
323097003680	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
323097003681	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
323097003682	haemagglutination activity domain; Region: Haemagg_act; pfam05860
323097003683	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
323097003684	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097003685	dimerization interface [polypeptide binding]; other site
323097003686	putative DNA binding site [nucleotide binding]; other site
323097003687	putative Zn2+ binding site [ion binding]; other site
323097003688	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
323097003689	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323097003690	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
323097003691	Putative phosphatase (DUF442); Region: DUF442; cl17385
323097003692	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
323097003693	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
323097003694	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
323097003695	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
323097003696	[4Fe-4S] binding site [ion binding]; other site
323097003697	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097003698	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097003699	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097003700	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097003701	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
323097003702	molybdopterin cofactor binding site; other site
323097003703	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
323097003704	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
323097003705	ABC-ATPase subunit  interface; other site
323097003706	dimer interface [polypeptide binding]; other site
323097003707	putative PBP binding regions; other site
323097003708	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
323097003709	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
323097003710	Walker A/P-loop; other site
323097003711	ATP binding site [chemical binding]; other site
323097003712	Q-loop/lid; other site
323097003713	ABC transporter signature motif; other site
323097003714	Walker B; other site
323097003715	D-loop; other site
323097003716	H-loop/switch region; other site
323097003717	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
323097003718	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
323097003719	intersubunit interface [polypeptide binding]; other site
323097003720	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097003721	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323097003722	N-terminal plug; other site
323097003723	ligand-binding site [chemical binding]; other site
323097003724	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
323097003725	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
323097003726	Autoinducer synthetase; Region: Autoind_synth; cl17404
323097003727	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
323097003728	Caspase domain; Region: Peptidase_C14; pfam00656
323097003729	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097003730	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323097003731	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
323097003732	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
323097003733	Walker A/P-loop; other site
323097003734	ATP binding site [chemical binding]; other site
323097003735	Q-loop/lid; other site
323097003736	ABC transporter signature motif; other site
323097003737	Walker B; other site
323097003738	D-loop; other site
323097003739	H-loop/switch region; other site
323097003740	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
323097003741	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
323097003742	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
323097003743	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
323097003744	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323097003745	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097003746	N-terminal plug; other site
323097003747	ligand-binding site [chemical binding]; other site
323097003748	SpoVR family protein; Provisional; Region: PRK11767
323097003749	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
323097003750	hypothetical protein; Provisional; Region: PRK05325
323097003751	PrkA family serine protein kinase; Provisional; Region: PRK15455
323097003752	AAA ATPase domain; Region: AAA_16; pfam13191
323097003753	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
323097003754	GYD domain; Region: GYD; pfam08734
323097003755	AMP nucleosidase; Provisional; Region: PRK07115
323097003756	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
323097003757	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
323097003758	Sulfatase; Region: Sulfatase; cl17466
323097003759	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198
323097003760	active site
323097003761	metal binding site [ion binding]; metal-binding site
323097003762	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
323097003763	UbiA prenyltransferase family; Region: UbiA; pfam01040
323097003764	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
323097003765	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
323097003766	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
323097003767	Cytochrome c; Region: Cytochrom_C; cl11414
323097003768	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
323097003769	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
323097003770	active site
323097003771	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323097003772	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097003773	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
323097003774	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
323097003775	Domain interface; other site
323097003776	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
323097003777	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
323097003778	glutamate dehydrogenase; Provisional; Region: PRK09414
323097003779	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
323097003780	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
323097003781	NAD(P) binding site [chemical binding]; other site
323097003782	sensor protein QseC; Provisional; Region: PRK10337
323097003783	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097003784	dimer interface [polypeptide binding]; other site
323097003785	phosphorylation site [posttranslational modification]
323097003786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097003787	ATP binding site [chemical binding]; other site
323097003788	Mg2+ binding site [ion binding]; other site
323097003789	G-X-G motif; other site
323097003790	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097003791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097003792	active site
323097003793	phosphorylation site [posttranslational modification]
323097003794	intermolecular recognition site; other site
323097003795	dimerization interface [polypeptide binding]; other site
323097003796	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097003797	DNA binding site [nucleotide binding]
323097003798	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
323097003799	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
323097003800	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
323097003801	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
323097003802	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
323097003803	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
323097003804	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
323097003805	Family of unknown function (DUF490); Region: DUF490; pfam04357
323097003806	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
323097003807	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
323097003808	DNA binding site [nucleotide binding]
323097003809	catalytic residue [active]
323097003810	H2TH interface [polypeptide binding]; other site
323097003811	putative catalytic residues [active]
323097003812	turnover-facilitating residue; other site
323097003813	intercalation triad [nucleotide binding]; other site
323097003814	8OG recognition residue [nucleotide binding]; other site
323097003815	putative reading head residues; other site
323097003816	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
323097003817	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
323097003818	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
323097003819	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
323097003820	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
323097003821	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
323097003822	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323097003823	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
323097003824	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
323097003825	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323097003826	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
323097003827	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
323097003828	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
323097003829	Phage Tail Collar Domain; Region: Collar; pfam07484
323097003830	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
323097003831	Phage Tail Collar Domain; Region: Collar; pfam07484
323097003832	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
323097003833	Phage Tail Collar Domain; Region: Collar; pfam07484
323097003834	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
323097003835	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323097003836	Coenzyme A binding pocket [chemical binding]; other site
323097003837	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
323097003838	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
323097003839	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
323097003840	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
323097003841	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
323097003842	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
323097003843	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323097003844	catalytic residues [active]
323097003845	BNR repeat-like domain; Region: BNR_2; pfam13088
323097003846	BNR repeat-like domain; Region: BNR_2; pfam13088
323097003847	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323097003848	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097003849	N-terminal plug; other site
323097003850	ligand-binding site [chemical binding]; other site
323097003851	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
323097003852	Putative ParB-like nuclease; Region: ParBc_2; cl17538
323097003853	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
323097003854	putative active site [active]
323097003855	putative metal binding residues [ion binding]; other site
323097003856	putative triphosphate binding site [ion binding]; other site
323097003857	signature motif; other site
323097003858	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
323097003859	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097003860	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097003861	protein binding site [polypeptide binding]; other site
323097003862	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097003863	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
323097003864	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097003865	protein binding site [polypeptide binding]; other site
323097003866	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
323097003867	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323097003868	DNA binding residues [nucleotide binding]
323097003869	dimerization interface [polypeptide binding]; other site
323097003870	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
323097003871	putative chaperone; Provisional; Region: PRK11678
323097003872	nucleotide binding site [chemical binding]; other site
323097003873	putative NEF/HSP70 interaction site [polypeptide binding]; other site
323097003874	SBD interface [polypeptide binding]; other site
323097003875	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
323097003876	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
323097003877	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
323097003878	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
323097003879	RNA binding site [nucleotide binding]; other site
323097003880	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
323097003881	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323097003882	catalytic loop [active]
323097003883	iron binding site [ion binding]; other site
323097003884	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
323097003885	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
323097003886	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
323097003887	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
323097003888	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
323097003889	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
323097003890	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323097003891	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097003892	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323097003893	dimerization interface [polypeptide binding]; other site
323097003894	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
323097003895	Glutamine amidotransferase class-I; Region: GATase; pfam00117
323097003896	glutamine binding [chemical binding]; other site
323097003897	catalytic triad [active]
323097003898	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
323097003899	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
323097003900	chorismate binding enzyme; Region: Chorismate_bind; cl10555
323097003901	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097003902	PAS domain; Region: PAS_9; pfam13426
323097003903	putative active site [active]
323097003904	heme pocket [chemical binding]; other site
323097003905	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
323097003906	dimer interface [polypeptide binding]; other site
323097003907	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
323097003908	putative CheW interface [polypeptide binding]; other site
323097003909	Homeodomain-like domain; Region: HTH_23; pfam13384
323097003910	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323097003911	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097003912	P-loop; other site
323097003913	Magnesium ion binding site [ion binding]; other site
323097003914	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
323097003915	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
323097003916	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323097003917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
323097003918	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
323097003919	putative active site [active]
323097003920	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
323097003921	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323097003922	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097003923	Walker A/P-loop; other site
323097003924	ATP binding site [chemical binding]; other site
323097003925	Q-loop/lid; other site
323097003926	ABC transporter signature motif; other site
323097003927	Walker B; other site
323097003928	D-loop; other site
323097003929	H-loop/switch region; other site
323097003930	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
323097003931	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097003932	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097003933	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323097003934	Sel1-like repeats; Region: SEL1; smart00671
323097003935	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323097003936	Sel1-like repeats; Region: SEL1; smart00671
323097003937	Sel1-like repeats; Region: SEL1; smart00671
323097003938	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323097003939	Sel1-like repeats; Region: SEL1; smart00671
323097003940	Sel1-like repeats; Region: SEL1; smart00671
323097003941	Sel1-like repeats; Region: SEL1; smart00671
323097003942	Sel1-like repeats; Region: SEL1; smart00671
323097003943	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
323097003944	putative ligand binding site [chemical binding]; other site
323097003945	putative catalytic site [active]
323097003946	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
323097003947	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
323097003948	active site
323097003949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097003950	TPR motif; other site
323097003951	Tetratricopeptide repeat; Region: TPR_16; pfam13432
323097003952	binding surface
323097003953	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
323097003954	active site
323097003955	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
323097003956	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
323097003957	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
323097003958	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
323097003959	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
323097003960	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
323097003961	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
323097003962	NAD binding site [chemical binding]; other site
323097003963	substrate binding site [chemical binding]; other site
323097003964	homodimer interface [polypeptide binding]; other site
323097003965	active site
323097003966	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
323097003967	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
323097003968	substrate binding site; other site
323097003969	tetramer interface; other site
323097003970	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
323097003971	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
323097003972	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
323097003973	NADP binding site [chemical binding]; other site
323097003974	active site
323097003975	putative substrate binding site [chemical binding]; other site
323097003976	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323097003977	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
323097003978	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
323097003979	Probable Catalytic site; other site
323097003980	metal-binding site
323097003981	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
323097003982	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
323097003983	Probable Catalytic site; other site
323097003984	metal-binding site
323097003985	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097003986	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
323097003987	putative ADP-binding pocket [chemical binding]; other site
323097003988	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
323097003989	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097003990	motif II; other site
323097003991	Predicted transcriptional regulators [Transcription]; Region: COG1695
323097003992	Transcriptional regulator PadR-like family; Region: PadR; cl17335
323097003993	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
323097003994	AAA ATPase domain; Region: AAA_16; pfam13191
323097003995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097003996	TPR motif; other site
323097003997	binding surface
323097003998	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097003999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097004000	binding surface
323097004001	TPR motif; other site
323097004002	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097004003	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097004004	TPR motif; other site
323097004005	binding surface
323097004006	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097004007	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097004008	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097004009	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097004010	TPR motif; other site
323097004011	binding surface
323097004012	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097004013	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097004014	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
323097004015	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
323097004016	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
323097004017	FMN binding site [chemical binding]; other site
323097004018	substrate binding site [chemical binding]; other site
323097004019	putative catalytic residue [active]
323097004020	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
323097004021	SlyX; Region: SlyX; pfam04102
323097004022	rhodanese superfamily protein; Provisional; Region: PRK05320
323097004023	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
323097004024	active site residue [active]
323097004025	CsbD-like; Region: CsbD; pfam05532
323097004026	Nitrate and nitrite sensing; Region: NIT; pfam08376
323097004027	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
323097004028	dimerization interface [polypeptide binding]; other site
323097004029	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
323097004030	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
323097004031	dimer interface [polypeptide binding]; other site
323097004032	putative CheW interface [polypeptide binding]; other site
323097004033	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323097004034	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323097004035	E3 interaction surface; other site
323097004036	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097004037	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
323097004038	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323097004039	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323097004040	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
323097004041	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
323097004042	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323097004043	active site
323097004044	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
323097004045	acetyl-CoA acetyltransferase; Provisional; Region: PRK08170
323097004046	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
323097004047	dimer interface [polypeptide binding]; other site
323097004048	active site
323097004049	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
323097004050	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
323097004051	substrate binding site [chemical binding]; other site
323097004052	oxyanion hole (OAH) forming residues; other site
323097004053	trimer interface [polypeptide binding]; other site
323097004054	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
323097004055	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
323097004056	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
323097004057	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
323097004058	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
323097004059	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
323097004060	lytic murein transglycosylase; Region: MltB_2; TIGR02283
323097004061	murein hydrolase B; Provisional; Region: PRK10760; cl17906
323097004062	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323097004063	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
323097004064	Moco binding site; other site
323097004065	metal coordination site [ion binding]; other site
323097004066	Cytochrome c; Region: Cytochrom_C; pfam00034
323097004067	Transposase domain (DUF772); Region: DUF772; pfam05598
323097004068	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097004069	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097004070	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323097004071	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097004072	non-specific DNA binding site [nucleotide binding]; other site
323097004073	salt bridge; other site
323097004074	sequence-specific DNA binding site [nucleotide binding]; other site
323097004075	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
323097004076	Domain of unknown function (DUF955); Region: DUF955; pfam06114
323097004077	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
323097004078	isocitrate lyase; Provisional; Region: PRK15063
323097004079	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
323097004080	tetramer interface [polypeptide binding]; other site
323097004081	active site
323097004082	Mg2+/Mn2+ binding site [ion binding]; other site
323097004083	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
323097004084	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
323097004085	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323097004086	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
323097004087	putative C-terminal domain interface [polypeptide binding]; other site
323097004088	putative GSH binding site (G-site) [chemical binding]; other site
323097004089	putative dimer interface [polypeptide binding]; other site
323097004090	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
323097004091	N-terminal domain interface [polypeptide binding]; other site
323097004092	dimer interface [polypeptide binding]; other site
323097004093	substrate binding pocket (H-site) [chemical binding]; other site
323097004094	aspartate aminotransferase; Provisional; Region: PRK05764
323097004095	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323097004096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097004097	homodimer interface [polypeptide binding]; other site
323097004098	catalytic residue [active]
323097004099	Protein of unknown function (DUF992); Region: DUF992; pfam06186
323097004100	Protein of unknown function (DUF992); Region: DUF992; pfam06186
323097004101	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
323097004102	elongation factor G; Reviewed; Region: PRK12740
323097004103	G1 box; other site
323097004104	putative GEF interaction site [polypeptide binding]; other site
323097004105	GTP/Mg2+ binding site [chemical binding]; other site
323097004106	Switch I region; other site
323097004107	G2 box; other site
323097004108	G3 box; other site
323097004109	Switch II region; other site
323097004110	G4 box; other site
323097004111	G5 box; other site
323097004112	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
323097004113	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
323097004114	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
323097004115	Helix-turn-helix; Region: HTH_3; pfam01381
323097004116	non-specific DNA binding site [nucleotide binding]; other site
323097004117	salt bridge; other site
323097004118	sequence-specific DNA binding site [nucleotide binding]; other site
323097004119	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
323097004120	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
323097004121	Sulfate transporter family; Region: Sulfate_transp; pfam00916
323097004122	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
323097004123	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
323097004124	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
323097004125	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
323097004126	shikimate binding site; other site
323097004127	NAD(P) binding site [chemical binding]; other site
323097004128	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
323097004129	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
323097004130	ferrous iron transporter FeoB; Region: feoB; TIGR00437
323097004131	G1 box; other site
323097004132	GTP/Mg2+ binding site [chemical binding]; other site
323097004133	Switch I region; other site
323097004134	G2 box; other site
323097004135	G3 box; other site
323097004136	Switch II region; other site
323097004137	G4 box; other site
323097004138	G5 box; other site
323097004139	Nucleoside recognition; Region: Gate; pfam07670
323097004140	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
323097004141	Nucleoside recognition; Region: Gate; pfam07670
323097004142	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
323097004143	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
323097004144	active site
323097004145	substrate binding site [chemical binding]; other site
323097004146	FMN binding site [chemical binding]; other site
323097004147	putative catalytic residues [active]
323097004148	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
323097004149	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
323097004150	active site
323097004151	substrate binding site [chemical binding]; other site
323097004152	metal binding site [ion binding]; metal-binding site
323097004153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097004154	Major Facilitator Superfamily; Region: MFS_1; pfam07690
323097004155	putative substrate translocation pore; other site
323097004156	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323097004157	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323097004158	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
323097004159	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323097004160	catalytic residue [active]
323097004161	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
323097004162	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
323097004163	ligand binding site [chemical binding]; other site
323097004164	NAD binding site [chemical binding]; other site
323097004165	dimerization interface [polypeptide binding]; other site
323097004166	catalytic site [active]
323097004167	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
323097004168	putative L-serine binding site [chemical binding]; other site
323097004169	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
323097004170	putative deacylase active site [active]
323097004171	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
323097004172	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
323097004173	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
323097004174	GDP-binding site [chemical binding]; other site
323097004175	ACT binding site; other site
323097004176	IMP binding site; other site
323097004177	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
323097004178	methionine sulfoxide reductase B; Provisional; Region: PRK00222
323097004179	SelR domain; Region: SelR; pfam01641
323097004180	methionine sulfoxide reductase A; Provisional; Region: PRK13014
323097004181	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
323097004182	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
323097004183	active site
323097004184	tetramer interface; other site
323097004185	Transglycosylase SLT domain; Region: SLT_2; pfam13406
323097004186	murein hydrolase B; Provisional; Region: PRK10760; cl17906
323097004187	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323097004188	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
323097004189	active site
323097004190	oxyanion hole [active]
323097004191	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
323097004192	catalytic triad [active]
323097004193	Transposase domain (DUF772); Region: DUF772; pfam05598
323097004194	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097004195	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097004196	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
323097004197	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097004198	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
323097004199	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
323097004200	active site
323097004201	dimer interface [polypeptide binding]; other site
323097004202	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
323097004203	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
323097004204	active site
323097004205	FMN binding site [chemical binding]; other site
323097004206	substrate binding site [chemical binding]; other site
323097004207	3Fe-4S cluster binding site [ion binding]; other site
323097004208	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
323097004209	domain interface; other site
323097004210	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323097004211	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
323097004212	putative dimer interface [polypeptide binding]; other site
323097004213	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
323097004214	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
323097004215	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
323097004216	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
323097004217	active site
323097004218	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
323097004219	Response regulator receiver domain; Region: Response_reg; pfam00072
323097004220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097004221	active site
323097004222	phosphorylation site [posttranslational modification]
323097004223	intermolecular recognition site; other site
323097004224	dimerization interface [polypeptide binding]; other site
323097004225	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097004226	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
323097004227	catalytic residues [active]
323097004228	catalytic nucleophile [active]
323097004229	Presynaptic Site I dimer interface [polypeptide binding]; other site
323097004230	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
323097004231	Synaptic Flat tetramer interface [polypeptide binding]; other site
323097004232	Synaptic Site I dimer interface [polypeptide binding]; other site
323097004233	DNA binding site [nucleotide binding]
323097004234	Recombinase; Region: Recombinase; pfam07508
323097004235	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323097004236	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
323097004237	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
323097004238	DEAD-like helicases superfamily; Region: DEXDc; smart00487
323097004239	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097004240	ATP binding site [chemical binding]; other site
323097004241	putative Mg++ binding site [ion binding]; other site
323097004242	nucleotide binding region [chemical binding]; other site
323097004243	helicase superfamily c-terminal domain; Region: HELICc; smart00490
323097004244	ATP-binding site [chemical binding]; other site
323097004245	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
323097004246	PRC-barrel domain; Region: PRC; pfam05239
323097004247	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097004248	HWE histidine kinase; Region: HWE_HK; smart00911
323097004249	Winged helix-turn helix; Region: HTH_29; pfam13551
323097004250	Homeodomain-like domain; Region: HTH_23; cl17451
323097004251	Homeodomain-like domain; Region: HTH_32; pfam13565
323097004252	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097004253	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097004254	LTXXQ motif family protein; Region: LTXXQ; pfam07813
323097004255	LTXXQ motif family protein; Region: LTXXQ; pfam07813
323097004256	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097004257	Histidine kinase; Region: HisKA_2; pfam07568
323097004258	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097004259	Mg2+ binding site [ion binding]; other site
323097004260	G-X-G motif; other site
323097004261	putative transposase OrfB; Reviewed; Region: PHA02517
323097004262	HTH-like domain; Region: HTH_21; pfam13276
323097004263	Integrase core domain; Region: rve; pfam00665
323097004264	Integrase core domain; Region: rve_3; pfam13683
323097004265	TraH_2; Region: TraH_2; cl17600
323097004266	Cold shock proteins [Transcription]; Region: CspC; COG1278
323097004267	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
323097004268	Fatty acid desaturase; Region: FA_desaturase; pfam00487
323097004269	putative di-iron ligands [ion binding]; other site
323097004270	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
323097004271	NADH dehydrogenase subunit D; Validated; Region: PRK06075
323097004272	Winged helix-turn helix; Region: HTH_29; pfam13551
323097004273	Homeodomain-like domain; Region: HTH_23; cl17451
323097004274	Homeodomain-like domain; Region: HTH_32; pfam13565
323097004275	Winged helix-turn helix; Region: HTH_33; pfam13592
323097004276	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
323097004277	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
323097004278	ring oligomerisation interface [polypeptide binding]; other site
323097004279	ATP/Mg binding site [chemical binding]; other site
323097004280	stacking interactions; other site
323097004281	hinge regions; other site
323097004282	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
323097004283	oligomerisation interface [polypeptide binding]; other site
323097004284	mobile loop; other site
323097004285	roof hairpin; other site
323097004286	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
323097004287	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
323097004288	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
323097004289	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
323097004290	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
323097004291	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323097004292	catalytic loop [active]
323097004293	iron binding site [ion binding]; other site
323097004294	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
323097004295	Cytochrome c; Region: Cytochrom_C; pfam00034
323097004296	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323097004297	Cytochrome c; Region: Cytochrom_C; pfam00034
323097004298	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
323097004299	Terminase-like family; Region: Terminase_6; pfam03237
323097004300	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
323097004301	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097004302	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097004303	Winged helix-turn helix; Region: HTH_29; pfam13551
323097004304	Homeodomain-like domain; Region: HTH_32; pfam13565
323097004305	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
323097004306	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
323097004307	NAD(P) binding site [chemical binding]; other site
323097004308	homodimer interface [polypeptide binding]; other site
323097004309	substrate binding site [chemical binding]; other site
323097004310	active site
323097004311	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
323097004312	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
323097004313	inhibitor-cofactor binding pocket; inhibition site
323097004314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097004315	catalytic residue [active]
323097004316	pseudaminic acid synthase; Region: PseI; TIGR03586
323097004317	NeuB family; Region: NeuB; pfam03102
323097004318	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
323097004319	NeuB binding interface [polypeptide binding]; other site
323097004320	putative substrate binding site [chemical binding]; other site
323097004321	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
323097004322	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097004323	motif II; other site
323097004324	Methyltransferase domain; Region: Methyltransf_31; pfam13847
323097004325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097004326	S-adenosylmethionine binding site [chemical binding]; other site
323097004327	pseudaminic acid biosynthesis-associated methylase; Region: Pse_Me-ase; TIGR03587
323097004328	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
323097004329	ligand binding site; other site
323097004330	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
323097004331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097004332	Walker A motif; other site
323097004333	ATP binding site [chemical binding]; other site
323097004334	Walker B motif; other site
323097004335	arginine finger; other site
323097004336	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
323097004337	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
323097004338	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097004339	Walker A/P-loop; other site
323097004340	ATP binding site [chemical binding]; other site
323097004341	Q-loop/lid; other site
323097004342	ABC transporter signature motif; other site
323097004343	Walker B; other site
323097004344	D-loop; other site
323097004345	H-loop/switch region; other site
323097004346	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
323097004347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097004348	dimer interface [polypeptide binding]; other site
323097004349	conserved gate region; other site
323097004350	putative PBP binding loops; other site
323097004351	ABC-ATPase subunit interface; other site
323097004352	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
323097004353	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097004354	dimer interface [polypeptide binding]; other site
323097004355	conserved gate region; other site
323097004356	putative PBP binding loops; other site
323097004357	ABC-ATPase subunit interface; other site
323097004358	PAS fold; Region: PAS_4; pfam08448
323097004359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097004360	PAS fold; Region: PAS_3; pfam08447
323097004361	putative active site [active]
323097004362	heme pocket [chemical binding]; other site
323097004363	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097004364	HWE histidine kinase; Region: HWE_HK; smart00911
323097004365	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
323097004366	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097004367	binding surface
323097004368	TPR motif; other site
323097004369	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097004370	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
323097004371	pyruvate kinase; Provisional; Region: PRK06247
323097004372	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
323097004373	domain interfaces; other site
323097004374	active site
323097004375	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
323097004376	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
323097004377	hypothetical protein; Provisional; Region: PRK13694
323097004378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
323097004379	Peptidase M15; Region: Peptidase_M15_3; cl01194
323097004380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
323097004381	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323097004382	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097004383	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
323097004384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097004385	active site
323097004386	phosphorylation site [posttranslational modification]
323097004387	intermolecular recognition site; other site
323097004388	dimerization interface [polypeptide binding]; other site
323097004389	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097004390	Walker A motif; other site
323097004391	ATP binding site [chemical binding]; other site
323097004392	Walker B motif; other site
323097004393	arginine finger; other site
323097004394	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
323097004395	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
323097004396	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
323097004397	active site
323097004398	Zn binding site [ion binding]; other site
323097004399	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
323097004400	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
323097004401	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
323097004402	ligand binding site [chemical binding]; other site
323097004403	homodimer interface [polypeptide binding]; other site
323097004404	NAD(P) binding site [chemical binding]; other site
323097004405	trimer interface B [polypeptide binding]; other site
323097004406	trimer interface A [polypeptide binding]; other site
323097004407	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
323097004408	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
323097004409	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
323097004410	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
323097004411	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
323097004412	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
323097004413	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
323097004414	amphipathic channel; other site
323097004415	Asn-Pro-Ala signature motifs; other site
323097004416	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
323097004417	ATP-grasp domain; Region: ATP-grasp; pfam02222
323097004418	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
323097004419	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323097004420	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323097004421	metal binding site [ion binding]; metal-binding site
323097004422	active site
323097004423	I-site; other site
323097004424	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
323097004425	Uncharacterized small protein [Function unknown]; Region: COG5570
323097004426	hydroxyglutarate oxidase; Provisional; Region: PRK11728
323097004427	Predicted dehydrogenase [General function prediction only]; Region: COG0579
323097004428	PAS fold; Region: PAS_7; pfam12860
323097004429	PAS domain; Region: PAS; smart00091
323097004430	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323097004431	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097004432	putative active site [active]
323097004433	heme pocket [chemical binding]; other site
323097004434	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323097004435	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323097004436	metal binding site [ion binding]; metal-binding site
323097004437	active site
323097004438	I-site; other site
323097004439	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323097004440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097004441	dimer interface [polypeptide binding]; other site
323097004442	conserved gate region; other site
323097004443	putative PBP binding loops; other site
323097004444	ABC-ATPase subunit interface; other site
323097004445	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
323097004446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097004447	dimer interface [polypeptide binding]; other site
323097004448	conserved gate region; other site
323097004449	putative PBP binding loops; other site
323097004450	ABC-ATPase subunit interface; other site
323097004451	AsmA family; Region: AsmA; pfam05170
323097004452	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
323097004453	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
323097004454	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
323097004455	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
323097004456	K+-transporting ATPase, c chain; Region: KdpC; cl00944
323097004457	PAS domain; Region: PAS_8; pfam13188
323097004458	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323097004459	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097004460	putative active site [active]
323097004461	heme pocket [chemical binding]; other site
323097004462	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097004463	dimer interface [polypeptide binding]; other site
323097004464	phosphorylation site [posttranslational modification]
323097004465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097004466	ATP binding site [chemical binding]; other site
323097004467	Mg2+ binding site [ion binding]; other site
323097004468	G-X-G motif; other site
323097004469	Phasin protein; Region: Phasin_2; cl11491
323097004470	Phasin protein; Region: Phasin_2; cl11491
323097004471	PRC-barrel domain; Region: PRC; pfam05239
323097004472	Uncharacterized conserved protein [Function unknown]; Region: COG5361
323097004473	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
323097004474	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
323097004475	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
323097004476	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
323097004477	NodB motif; other site
323097004478	active site
323097004479	catalytic site [active]
323097004480	metal binding site [ion binding]; metal-binding site
323097004481	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
323097004482	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
323097004483	Cupin domain; Region: Cupin_2; cl17218
323097004484	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323097004485	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323097004486	ligand binding site [chemical binding]; other site
323097004487	flexible hinge region; other site
323097004488	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
323097004489	putative switch regulator; other site
323097004490	non-specific DNA interactions [nucleotide binding]; other site
323097004491	DNA binding site [nucleotide binding]
323097004492	sequence specific DNA binding site [nucleotide binding]; other site
323097004493	putative cAMP binding site [chemical binding]; other site
323097004494	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
323097004495	Transposase; Region: HTH_Tnp_1; pfam01527
323097004496	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323097004497	Helix-turn-helix domain; Region: HTH_28; pfam13518
323097004498	Winged helix-turn helix; Region: HTH_29; pfam13551
323097004499	Homeodomain-like domain; Region: HTH_32; pfam13565
323097004500	Transposase domain (DUF772); Region: DUF772; pfam05598
323097004501	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097004502	CsbD-like; Region: CsbD; pfam05532
323097004503	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
323097004504	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
323097004505	amidase catalytic site [active]
323097004506	Zn binding residues [ion binding]; other site
323097004507	substrate binding site [chemical binding]; other site
323097004508	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323097004509	MraW methylase family; Region: Methyltransf_5; cl17771
323097004510	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
323097004511	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
323097004512	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
323097004513	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
323097004514	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
323097004515	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
323097004516	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
323097004517	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323097004518	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323097004519	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
323097004520	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
323097004521	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323097004522	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323097004523	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
323097004524	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
323097004525	Mg++ binding site [ion binding]; other site
323097004526	putative catalytic motif [active]
323097004527	putative substrate binding site [chemical binding]; other site
323097004528	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
323097004529	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
323097004530	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323097004531	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323097004532	cell division protein FtsW; Region: ftsW; TIGR02614
323097004533	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
323097004534	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
323097004535	active site
323097004536	homodimer interface [polypeptide binding]; other site
323097004537	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
323097004538	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
323097004539	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323097004540	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323097004541	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
323097004542	FAD binding domain; Region: FAD_binding_4; pfam01565
323097004543	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
323097004544	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
323097004545	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
323097004546	ATP-grasp domain; Region: ATP-grasp_4; cl17255
323097004547	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
323097004548	Cell division protein FtsQ; Region: FtsQ; pfam03799
323097004549	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
323097004550	Cell division protein FtsA; Region: FtsA; smart00842
323097004551	Cell division protein FtsA; Region: FtsA; pfam14450
323097004552	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
323097004553	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
323097004554	nucleotide binding site [chemical binding]; other site
323097004555	SulA interaction site; other site
323097004556	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
323097004557	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
323097004558	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
323097004559	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
323097004560	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
323097004561	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
323097004562	Walker A/P-loop; other site
323097004563	ATP binding site [chemical binding]; other site
323097004564	Q-loop/lid; other site
323097004565	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
323097004566	ABC transporter signature motif; other site
323097004567	Walker B; other site
323097004568	D-loop; other site
323097004569	H-loop/switch region; other site
323097004570	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
323097004571	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
323097004572	nucleotide binding pocket [chemical binding]; other site
323097004573	K-X-D-G motif; other site
323097004574	catalytic site [active]
323097004575	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
323097004576	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
323097004577	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
323097004578	Dimer interface [polypeptide binding]; other site
323097004579	BRCT sequence motif; other site
323097004580	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
323097004581	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
323097004582	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
323097004583	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323097004584	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097004585	Walker A/P-loop; other site
323097004586	ATP binding site [chemical binding]; other site
323097004587	Q-loop/lid; other site
323097004588	ABC transporter signature motif; other site
323097004589	Walker B; other site
323097004590	D-loop; other site
323097004591	H-loop/switch region; other site
323097004592	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
323097004593	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
323097004594	NAD binding site [chemical binding]; other site
323097004595	homodimer interface [polypeptide binding]; other site
323097004596	active site
323097004597	substrate binding site [chemical binding]; other site
323097004598	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
323097004599	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
323097004600	putative active site [active]
323097004601	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
323097004602	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097004603	active site
323097004604	motif I; other site
323097004605	motif II; other site
323097004606	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
323097004607	dimer interface [polypeptide binding]; other site
323097004608	active site
323097004609	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
323097004610	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
323097004611	putative active site [active]
323097004612	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
323097004613	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
323097004614	NADP binding site [chemical binding]; other site
323097004615	homopentamer interface [polypeptide binding]; other site
323097004616	substrate binding site [chemical binding]; other site
323097004617	active site
323097004618	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
323097004619	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
323097004620	putative ribose interaction site [chemical binding]; other site
323097004621	putative ADP binding site [chemical binding]; other site
323097004622	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
323097004623	active site
323097004624	nucleotide binding site [chemical binding]; other site
323097004625	HIGH motif; other site
323097004626	KMSKS motif; other site
323097004627	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
323097004628	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
323097004629	NAD(P) binding site [chemical binding]; other site
323097004630	homodimer interface [polypeptide binding]; other site
323097004631	substrate binding site [chemical binding]; other site
323097004632	active site
323097004633	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
323097004634	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
323097004635	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
323097004636	putative NAD(P) binding site [chemical binding]; other site
323097004637	active site
323097004638	putative substrate binding site [chemical binding]; other site
323097004639	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
323097004640	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
323097004641	Substrate binding site; other site
323097004642	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
323097004643	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
323097004644	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
323097004645	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
323097004646	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
323097004647	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
323097004648	inhibitor-cofactor binding pocket; inhibition site
323097004649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097004650	catalytic residue [active]
323097004651	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
323097004652	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
323097004653	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
323097004654	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
323097004655	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
323097004656	CHRD domain; Region: CHRD; pfam07452
323097004657	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
323097004658	AsnC family; Region: AsnC_trans_reg; pfam01037
323097004659	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
323097004660	dimer interface [polypeptide binding]; other site
323097004661	substrate binding site [chemical binding]; other site
323097004662	ATP binding site [chemical binding]; other site
323097004663	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323097004664	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
323097004665	putative active site [active]
323097004666	putative metal binding site [ion binding]; other site
323097004667	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
323097004668	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
323097004669	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
323097004670	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
323097004671	active site
323097004672	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
323097004673	Permease; Region: Permease; pfam02405
323097004674	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
323097004675	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
323097004676	Walker A/P-loop; other site
323097004677	ATP binding site [chemical binding]; other site
323097004678	Q-loop/lid; other site
323097004679	ABC transporter signature motif; other site
323097004680	Walker B; other site
323097004681	D-loop; other site
323097004682	H-loop/switch region; other site
323097004683	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
323097004684	mce related protein; Region: MCE; pfam02470
323097004685	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
323097004686	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323097004687	catalytic loop [active]
323097004688	iron binding site [ion binding]; other site
323097004689	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
323097004690	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
323097004691	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
323097004692	active site
323097004693	oxyanion hole [active]
323097004694	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
323097004695	catalytic triad [active]
323097004696	Predicted integral membrane protein [Function unknown]; Region: COG0392
323097004697	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323097004698	Ligand Binding Site [chemical binding]; other site
323097004699	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323097004700	catalytic core [active]
323097004701	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
323097004702	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
323097004703	methionine sulfoxide reductase B; Provisional; Region: PRK00222
323097004704	SelR domain; Region: SelR; pfam01641
323097004705	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
323097004706	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
323097004707	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
323097004708	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
323097004709	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
323097004710	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
323097004711	tyrosine decarboxylase; Region: PLN02880
323097004712	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
323097004713	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323097004714	catalytic residue [active]
323097004715	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK12791
323097004716	flagellin; Reviewed; Region: PRK12688
323097004717	flagellin; Reviewed; Region: PRK12688
323097004718	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
323097004719	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
323097004720	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
323097004721	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
323097004722	Autotransporter beta-domain; Region: Autotransporter; smart00869
323097004723	chemotactic signal-response protein CheL; Provisional; Region: PRK12790
323097004724	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
323097004725	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
323097004726	flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787
323097004727	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
323097004728	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323097004729	Domain of unknown function (DUF955); Region: DUF955; cl01076
323097004730	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
323097004731	PLD-like domain; Region: PLDc_2; pfam13091
323097004732	putative active site [active]
323097004733	catalytic site [active]
323097004734	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097004735	ATP binding site [chemical binding]; other site
323097004736	putative Mg++ binding site [ion binding]; other site
323097004737	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097004738	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
323097004739	nucleotide binding region [chemical binding]; other site
323097004740	ATP-binding site [chemical binding]; other site
323097004741	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
323097004742	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
323097004743	Protein of unknown function (DUF3780); Region: DUF3780; pfam12635
323097004744	Protein of unknown function (DUF499); Region: DUF499; pfam04465
323097004745	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
323097004746	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323097004747	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
323097004748	putative active site [active]
323097004749	putative metal binding site [ion binding]; other site
323097004750	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097004751	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
323097004752	Walker A motif; other site
323097004753	ATP binding site [chemical binding]; other site
323097004754	Walker B motif; other site
323097004755	arginine finger; other site
323097004756	Peptidase family M41; Region: Peptidase_M41; pfam01434
323097004757	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
323097004758	Integrase core domain; Region: rve; pfam00665
323097004759	Bacterial TniB protein; Region: TniB; pfam05621
323097004760	AAA domain; Region: AAA_22; pfam13401
323097004761	TniQ; Region: TniQ; pfam06527
323097004762	Helix-turn-helix domain; Region: HTH_17; pfam12728
323097004763	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
323097004764	Homeodomain-like domain; Region: HTH_23; pfam13384
323097004765	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
323097004766	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
323097004767	ATP binding site [chemical binding]; other site
323097004768	substrate interface [chemical binding]; other site
323097004769	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
323097004770	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
323097004771	Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462
323097004772	Domain of unknown function (DUF955); Region: DUF955; pfam06114
323097004773	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323097004774	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323097004775	ligand binding site [chemical binding]; other site
323097004776	flexible hinge region; other site
323097004777	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
323097004778	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
323097004779	nucleophile elbow; other site
323097004780	Transposase domain (DUF772); Region: DUF772; pfam05598
323097004781	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097004782	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097004783	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097004784	Transposase, Mutator family; Region: Transposase_mut; pfam00872
323097004785	MULE transposase domain; Region: MULE; pfam10551
323097004786	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
323097004787	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
323097004788	SAF-like; Region: SAF_2; pfam13144
323097004789	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
323097004790	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
323097004791	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
323097004792	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
323097004793	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
323097004794	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
323097004795	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
323097004796	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785
323097004797	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
323097004798	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
323097004799	Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559
323097004800	Uncharacterized conserved protein [Function unknown]; Region: COG3334
323097004801	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
323097004802	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
323097004803	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
323097004804	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
323097004805	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
323097004806	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
323097004807	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
323097004808	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
323097004809	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00732
323097004810	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
323097004811	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
323097004812	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
323097004813	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
323097004814	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097004815	PAS domain; Region: PAS_9; pfam13426
323097004816	putative active site [active]
323097004817	heme pocket [chemical binding]; other site
323097004818	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
323097004819	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097004820	dimer interface [polypeptide binding]; other site
323097004821	phosphorylation site [posttranslational modification]
323097004822	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097004823	ATP binding site [chemical binding]; other site
323097004824	Mg2+ binding site [ion binding]; other site
323097004825	G-X-G motif; other site
323097004826	Response regulator receiver domain; Region: Response_reg; pfam00072
323097004827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097004828	active site
323097004829	phosphorylation site [posttranslational modification]
323097004830	intermolecular recognition site; other site
323097004831	dimerization interface [polypeptide binding]; other site
323097004832	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
323097004833	Predicted integral membrane protein [Function unknown]; Region: COG5436
323097004834	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
323097004835	Transglycosylase; Region: Transgly; pfam00912
323097004836	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
323097004837	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
323097004838	hypothetical protein; Provisional; Region: PRK05170
323097004839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097004840	putative substrate translocation pore; other site
323097004841	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
323097004842	Uncharacterized conserved protein [Function unknown]; Region: COG5323
323097004843	Terminase-like family; Region: Terminase_6; pfam03237
323097004844	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
323097004845	GIY-YIG motif/motif A; other site
323097004846	putative active site [active]
323097004847	putative metal binding site [ion binding]; other site
323097004848	Phage-related protein [Function unknown]; Region: COG4695
323097004849	Phage portal protein; Region: Phage_portal; pfam04860
323097004850	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
323097004851	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
323097004852	Phage capsid family; Region: Phage_capsid; pfam05065
323097004853	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
323097004854	active site
323097004855	substrate binding sites [chemical binding]; other site
323097004856	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
323097004857	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
323097004858	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
323097004859	oligomerization interface [polypeptide binding]; other site
323097004860	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
323097004861	Phage major tail protein 2; Region: Phage_tail_2; cl11463
323097004862	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
323097004863	phage conserved hypothetical protein; Region: phage_TIGR02216
323097004864	Phage-related minor tail protein [Function unknown]; Region: COG5281
323097004865	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
323097004866	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
323097004867	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
323097004868	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
323097004869	NlpC/P60 family; Region: NLPC_P60; cl17555
323097004870	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
323097004871	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
323097004872	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
323097004873	Putative phage tail protein; Region: Phage-tail_3; pfam13550
323097004874	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
323097004875	D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662
323097004876	Predicted chitinase [General function prediction only]; Region: COG3179
323097004877	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097004878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097004879	active site
323097004880	phosphorylation site [posttranslational modification]
323097004881	intermolecular recognition site; other site
323097004882	dimerization interface [polypeptide binding]; other site
323097004883	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097004884	DNA binding site [nucleotide binding]
323097004885	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097004886	HAMP domain; Region: HAMP; pfam00672
323097004887	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097004888	ATP binding site [chemical binding]; other site
323097004889	Mg2+ binding site [ion binding]; other site
323097004890	G-X-G motif; other site
323097004891	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
323097004892	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293
323097004893	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
323097004894	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
323097004895	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
323097004896	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
323097004897	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
323097004898	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
323097004899	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097004900	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097004901	protein binding site [polypeptide binding]; other site
323097004902	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097004903	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097004904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097004905	active site
323097004906	phosphorylation site [posttranslational modification]
323097004907	intermolecular recognition site; other site
323097004908	dimerization interface [polypeptide binding]; other site
323097004909	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097004910	DNA binding site [nucleotide binding]
323097004911	Cytochrome c2 [Energy production and conversion]; Region: COG3474
323097004912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097004913	putative substrate translocation pore; other site
323097004914	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
323097004915	dimerization interface [polypeptide binding]; other site
323097004916	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097004917	dimer interface [polypeptide binding]; other site
323097004918	phosphorylation site [posttranslational modification]
323097004919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097004920	ATP binding site [chemical binding]; other site
323097004921	Mg2+ binding site [ion binding]; other site
323097004922	G-X-G motif; other site
323097004923	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
323097004924	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
323097004925	metal binding triad; other site
323097004926	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
323097004927	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
323097004928	metal binding triad; other site
323097004929	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
323097004930	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097004931	PAS fold; Region: PAS_3; pfam08447
323097004932	putative active site [active]
323097004933	heme pocket [chemical binding]; other site
323097004934	PAS fold; Region: PAS_7; pfam12860
323097004935	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097004936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097004937	dimer interface [polypeptide binding]; other site
323097004938	phosphorylation site [posttranslational modification]
323097004939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097004940	ATP binding site [chemical binding]; other site
323097004941	Mg2+ binding site [ion binding]; other site
323097004942	G-X-G motif; other site
323097004943	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
323097004944	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
323097004945	Cation efflux family; Region: Cation_efflux; cl00316
323097004946	Cation efflux family; Region: Cation_efflux; cl00316
323097004947	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
323097004948	IHF dimer interface [polypeptide binding]; other site
323097004949	IHF - DNA interface [nucleotide binding]; other site
323097004950	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
323097004951	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
323097004952	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
323097004953	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
323097004954	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
323097004955	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
323097004956	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
323097004957	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
323097004958	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
323097004959	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
323097004960	CPxP  motif; other site
323097004961	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
323097004962	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
323097004963	homodimer interface [polypeptide binding]; other site
323097004964	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
323097004965	active site pocket [active]
323097004966	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
323097004967	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
323097004968	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
323097004969	active site
323097004970	catalytic site [active]
323097004971	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
323097004972	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
323097004973	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
323097004974	catalytic site [active]
323097004975	active site
323097004976	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
323097004977	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
323097004978	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
323097004979	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
323097004980	active site
323097004981	catalytic site [active]
323097004982	glycogen branching enzyme; Provisional; Region: PRK05402
323097004983	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
323097004984	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
323097004985	active site
323097004986	catalytic site [active]
323097004987	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
323097004988	trehalose synthase; Region: treS_nterm; TIGR02456
323097004989	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
323097004990	active site
323097004991	catalytic site [active]
323097004992	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
323097004993	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
323097004994	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
323097004995	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
323097004996	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
323097004997	active site
323097004998	homodimer interface [polypeptide binding]; other site
323097004999	catalytic site [active]
323097005000	acceptor binding site [chemical binding]; other site
323097005001	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
323097005002	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
323097005003	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
323097005004	catalytic motif [active]
323097005005	Catalytic residue [active]
323097005006	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097005007	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097005008	dimer interface [polypeptide binding]; other site
323097005009	phosphorylation site [posttranslational modification]
323097005010	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097005011	ATP binding site [chemical binding]; other site
323097005012	Mg2+ binding site [ion binding]; other site
323097005013	G-X-G motif; other site
323097005014	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
323097005015	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
323097005016	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
323097005017	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097005018	dimer interface [polypeptide binding]; other site
323097005019	putative metal binding site [ion binding]; other site
323097005020	Domain of unknown function DUF59; Region: DUF59; pfam01883
323097005021	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
323097005022	Walker A motif; other site
323097005023	Transposase domain (DUF772); Region: DUF772; pfam05598
323097005024	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097005025	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097005026	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
323097005027	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
323097005028	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
323097005029	DctM-like transporters; Region: DctM; pfam06808
323097005030	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
323097005031	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
323097005032	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097005033	FeS/SAM binding site; other site
323097005034	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
323097005035	phosphoglycolate phosphatase; Provisional; Region: PRK13222
323097005036	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097005037	motif II; other site
323097005038	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
323097005039	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323097005040	active site
323097005041	dimer interface [polypeptide binding]; other site
323097005042	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
323097005043	glutathione reductase; Validated; Region: PRK06116
323097005044	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
323097005045	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323097005046	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
323097005047	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
323097005048	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
323097005049	NAD synthetase; Provisional; Region: PRK13981
323097005050	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
323097005051	multimer interface [polypeptide binding]; other site
323097005052	active site
323097005053	catalytic triad [active]
323097005054	protein interface 1 [polypeptide binding]; other site
323097005055	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
323097005056	homodimer interface [polypeptide binding]; other site
323097005057	NAD binding pocket [chemical binding]; other site
323097005058	ATP binding pocket [chemical binding]; other site
323097005059	Mg binding site [ion binding]; other site
323097005060	active-site loop [active]
323097005061	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
323097005062	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
323097005063	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
323097005064	active site
323097005065	HIGH motif; other site
323097005066	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
323097005067	KMSKS motif; other site
323097005068	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
323097005069	tRNA binding surface [nucleotide binding]; other site
323097005070	anticodon binding site; other site
323097005071	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
323097005072	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323097005073	Coenzyme A binding pocket [chemical binding]; other site
323097005074	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
323097005075	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
323097005076	active site
323097005077	catalytic residues [active]
323097005078	metal binding site [ion binding]; metal-binding site
323097005079	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
323097005080	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
323097005081	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323097005082	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
323097005083	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
323097005084	Walker A/P-loop; other site
323097005085	ATP binding site [chemical binding]; other site
323097005086	Q-loop/lid; other site
323097005087	ABC transporter signature motif; other site
323097005088	Walker B; other site
323097005089	D-loop; other site
323097005090	H-loop/switch region; other site
323097005091	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
323097005092	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
323097005093	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
323097005094	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
323097005095	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323097005096	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
323097005097	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
323097005098	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323097005099	ligand binding site [chemical binding]; other site
323097005100	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
323097005101	Transposase domain (DUF772); Region: DUF772; pfam05598
323097005102	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097005103	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097005104	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
323097005105	active site residue [active]
323097005106	hypothetical protein; Provisional; Region: PRK08912
323097005107	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323097005108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097005109	homodimer interface [polypeptide binding]; other site
323097005110	catalytic residue [active]
323097005111	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
323097005112	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
323097005113	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
323097005114	putative acyl-acceptor binding pocket; other site
323097005115	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
323097005116	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
323097005117	dimer interface [polypeptide binding]; other site
323097005118	active site
323097005119	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
323097005120	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
323097005121	active site
323097005122	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
323097005123	acyl carrier protein; Provisional; Region: PRK06508
323097005124	HerA helicase [Replication, recombination, and repair]; Region: COG0433
323097005125	Domain of unknown function DUF87; Region: DUF87; pfam01935
323097005126	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
323097005127	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
323097005128	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097005129	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097005130	Transcriptional regulators [Transcription]; Region: MarR; COG1846
323097005131	MarR family; Region: MarR; pfam01047
323097005132	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
323097005133	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097005134	N-terminal plug; other site
323097005135	ligand-binding site [chemical binding]; other site
323097005136	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
323097005137	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323097005138	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323097005139	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
323097005140	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
323097005141	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
323097005142	Oligosaccharyltransferase subunit Ribophorin II; Region: Ribophorin_II; pfam05817
323097005143	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
323097005144	Peptidase family M50; Region: Peptidase_M50; pfam02163
323097005145	active site
323097005146	putative substrate binding region [chemical binding]; other site
323097005147	Cupin-like domain; Region: Cupin_8; pfam13621
323097005148	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
323097005149	PilZ domain; Region: PilZ; pfam07238
323097005150	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
323097005151	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
323097005152	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
323097005153	putative homodimer interface [polypeptide binding]; other site
323097005154	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
323097005155	heterodimer interface [polypeptide binding]; other site
323097005156	homodimer interface [polypeptide binding]; other site
323097005157	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
323097005158	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
323097005159	23S rRNA interface [nucleotide binding]; other site
323097005160	L7/L12 interface [polypeptide binding]; other site
323097005161	putative thiostrepton binding site; other site
323097005162	L25 interface [polypeptide binding]; other site
323097005163	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
323097005164	mRNA/rRNA interface [nucleotide binding]; other site
323097005165	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
323097005166	23S rRNA interface [nucleotide binding]; other site
323097005167	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
323097005168	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
323097005169	L11 interface [polypeptide binding]; other site
323097005170	putative EF-Tu interaction site [polypeptide binding]; other site
323097005171	putative EF-G interaction site [polypeptide binding]; other site
323097005172	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
323097005173	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
323097005174	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
323097005175	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
323097005176	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
323097005177	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
323097005178	RPB3 interaction site [polypeptide binding]; other site
323097005179	RPB1 interaction site [polypeptide binding]; other site
323097005180	RPB11 interaction site [polypeptide binding]; other site
323097005181	RPB10 interaction site [polypeptide binding]; other site
323097005182	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
323097005183	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
323097005184	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
323097005185	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
323097005186	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
323097005187	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
323097005188	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
323097005189	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
323097005190	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
323097005191	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
323097005192	DNA binding site [nucleotide binding]
323097005193	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
323097005194	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097005195	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
323097005196	Methyltransferase domain; Region: Methyltransf_11; pfam08241
323097005197	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
323097005198	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323097005199	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097005200	Walker A/P-loop; other site
323097005201	ATP binding site [chemical binding]; other site
323097005202	Q-loop/lid; other site
323097005203	ABC transporter signature motif; other site
323097005204	Walker B; other site
323097005205	D-loop; other site
323097005206	H-loop/switch region; other site
323097005207	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323097005208	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
323097005209	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
323097005210	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
323097005211	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323097005212	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
323097005213	ligand binding site [chemical binding]; other site
323097005214	flexible hinge region; other site
323097005215	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
323097005216	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
323097005217	S17 interaction site [polypeptide binding]; other site
323097005218	S8 interaction site; other site
323097005219	16S rRNA interaction site [nucleotide binding]; other site
323097005220	streptomycin interaction site [chemical binding]; other site
323097005221	23S rRNA interaction site [nucleotide binding]; other site
323097005222	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
323097005223	30S ribosomal protein S7; Validated; Region: PRK05302
323097005224	elongation factor G; Reviewed; Region: PRK00007
323097005225	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
323097005226	G1 box; other site
323097005227	putative GEF interaction site [polypeptide binding]; other site
323097005228	GTP/Mg2+ binding site [chemical binding]; other site
323097005229	Switch I region; other site
323097005230	G2 box; other site
323097005231	G3 box; other site
323097005232	Switch II region; other site
323097005233	G4 box; other site
323097005234	G5 box; other site
323097005235	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
323097005236	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
323097005237	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
323097005238	elongation factor Tu; Reviewed; Region: PRK00049
323097005239	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
323097005240	G1 box; other site
323097005241	GEF interaction site [polypeptide binding]; other site
323097005242	GTP/Mg2+ binding site [chemical binding]; other site
323097005243	Switch I region; other site
323097005244	G2 box; other site
323097005245	G3 box; other site
323097005246	Switch II region; other site
323097005247	G4 box; other site
323097005248	G5 box; other site
323097005249	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
323097005250	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
323097005251	Antibiotic Binding Site [chemical binding]; other site
323097005252	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
323097005253	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
323097005254	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
323097005255	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
323097005256	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
323097005257	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
323097005258	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
323097005259	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
323097005260	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
323097005261	putative translocon binding site; other site
323097005262	protein-rRNA interface [nucleotide binding]; other site
323097005263	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
323097005264	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
323097005265	G-X-X-G motif; other site
323097005266	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
323097005267	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
323097005268	23S rRNA interface [nucleotide binding]; other site
323097005269	5S rRNA interface [nucleotide binding]; other site
323097005270	putative antibiotic binding site [chemical binding]; other site
323097005271	L25 interface [polypeptide binding]; other site
323097005272	L27 interface [polypeptide binding]; other site
323097005273	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
323097005274	23S rRNA interface [nucleotide binding]; other site
323097005275	putative translocon interaction site; other site
323097005276	signal recognition particle (SRP54) interaction site; other site
323097005277	L23 interface [polypeptide binding]; other site
323097005278	trigger factor interaction site; other site
323097005279	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
323097005280	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
323097005281	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
323097005282	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
323097005283	RNA binding site [nucleotide binding]; other site
323097005284	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
323097005285	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
323097005286	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
323097005287	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
323097005288	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
323097005289	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
323097005290	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
323097005291	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
323097005292	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
323097005293	5S rRNA interface [nucleotide binding]; other site
323097005294	23S rRNA interface [nucleotide binding]; other site
323097005295	L5 interface [polypeptide binding]; other site
323097005296	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
323097005297	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
323097005298	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
323097005299	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
323097005300	23S rRNA binding site [nucleotide binding]; other site
323097005301	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
323097005302	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
323097005303	SecY translocase; Region: SecY; pfam00344
323097005304	adenylate kinase; Reviewed; Region: adk; PRK00279
323097005305	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
323097005306	AMP-binding site [chemical binding]; other site
323097005307	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
323097005308	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
323097005309	30S ribosomal protein S13; Region: bact_S13; TIGR03631
323097005310	30S ribosomal protein S11; Validated; Region: PRK05309
323097005311	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
323097005312	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
323097005313	alphaNTD - beta interaction site [polypeptide binding]; other site
323097005314	alphaNTD homodimer interface [polypeptide binding]; other site
323097005315	alphaNTD - beta' interaction site [polypeptide binding]; other site
323097005316	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
323097005317	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
323097005318	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
323097005319	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097005320	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097005321	protein binding site [polypeptide binding]; other site
323097005322	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097005323	protein binding site [polypeptide binding]; other site
323097005324	recombination factor protein RarA; Reviewed; Region: PRK13342
323097005325	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097005326	Walker A motif; other site
323097005327	ATP binding site [chemical binding]; other site
323097005328	Walker B motif; other site
323097005329	arginine finger; other site
323097005330	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
323097005331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097005332	binding surface
323097005333	TPR motif; other site
323097005334	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
323097005335	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323097005336	RNA binding surface [nucleotide binding]; other site
323097005337	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
323097005338	active site
323097005339	ATP12 chaperone protein; Region: ATP12; cl02228
323097005340	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
323097005341	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
323097005342	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
323097005343	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
323097005344	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
323097005345	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
323097005346	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
323097005347	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097005348	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323097005349	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
323097005350	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
323097005351	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981
323097005352	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
323097005353	putative phosphate acyltransferase; Provisional; Region: PRK05331
323097005354	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
323097005355	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
323097005356	dimer interface [polypeptide binding]; other site
323097005357	active site
323097005358	CoA binding pocket [chemical binding]; other site
323097005359	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
323097005360	IHF dimer interface [polypeptide binding]; other site
323097005361	IHF - DNA interface [nucleotide binding]; other site
323097005362	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
323097005363	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
323097005364	DNA binding residues [nucleotide binding]
323097005365	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
323097005366	Staphylococcal nuclease homologues; Region: SNc; smart00318
323097005367	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
323097005368	Catalytic site; other site
323097005369	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323097005370	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097005371	Repair protein; Region: Repair_PSII; pfam04536
323097005372	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097005373	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; pfam10124
323097005374	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
323097005375	Mor transcription activator family; Region: Mor; cl02360
323097005376	AAA domain; Region: AAA_22; pfam13401
323097005377	AAA domain; Region: AAA_30; pfam13604
323097005378	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
323097005379	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
323097005380	recombinase A; Provisional; Region: recA; PRK09354
323097005381	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
323097005382	hexamer interface [polypeptide binding]; other site
323097005383	Walker A motif; other site
323097005384	ATP binding site [chemical binding]; other site
323097005385	Walker B motif; other site
323097005386	glycine dehydrogenase; Provisional; Region: PRK05367
323097005387	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
323097005388	tetramer interface [polypeptide binding]; other site
323097005389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097005390	catalytic residue [active]
323097005391	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
323097005392	tetramer interface [polypeptide binding]; other site
323097005393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097005394	catalytic residue [active]
323097005395	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
323097005396	lipoyl attachment site [posttranslational modification]; other site
323097005397	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
323097005398	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
323097005399	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
323097005400	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
323097005401	motif 1; other site
323097005402	active site
323097005403	motif 2; other site
323097005404	motif 3; other site
323097005405	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
323097005406	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
323097005407	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097005408	isocitrate dehydrogenase; Validated; Region: PRK08299
323097005409	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
323097005410	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
323097005411	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
323097005412	putative active site [active]
323097005413	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
323097005414	Homeodomain-like domain; Region: HTH_23; pfam13384
323097005415	Winged helix-turn helix; Region: HTH_29; pfam13551
323097005416	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097005417	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097005418	Homeodomain-like domain; Region: HTH_23; pfam13384
323097005419	Winged helix-turn helix; Region: HTH_29; pfam13551
323097005420	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097005421	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097005422	cyanate hydratase; Validated; Region: PRK02866
323097005423	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
323097005424	oligomer interface [polypeptide binding]; other site
323097005425	active site
323097005426	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
323097005427	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
323097005428	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
323097005429	ATP binding site [chemical binding]; other site
323097005430	active site
323097005431	substrate binding site [chemical binding]; other site
323097005432	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
323097005433	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
323097005434	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
323097005435	putative active site [active]
323097005436	catalytic triad [active]
323097005437	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
323097005438	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
323097005439	dimerization interface [polypeptide binding]; other site
323097005440	ATP binding site [chemical binding]; other site
323097005441	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
323097005442	dimerization interface [polypeptide binding]; other site
323097005443	ATP binding site [chemical binding]; other site
323097005444	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
323097005445	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
323097005446	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
323097005447	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
323097005448	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
323097005449	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
323097005450	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
323097005451	putative GSH binding site [chemical binding]; other site
323097005452	catalytic residues [active]
323097005453	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
323097005454	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
323097005455	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
323097005456	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323097005457	RNA binding surface [nucleotide binding]; other site
323097005458	glutamate racemase; Provisional; Region: PRK00865
323097005459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
323097005460	PAS domain; Region: PAS_5; pfam07310
323097005461	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
323097005462	FOG: CBS domain [General function prediction only]; Region: COG0517
323097005463	hypothetical protein; Provisional; Region: PRK10279
323097005464	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
323097005465	nucleophile elbow; other site
323097005466	Transposase domain (DUF772); Region: DUF772; pfam05598
323097005467	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097005468	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097005469	hypothetical protein; Validated; Region: PRK00041
323097005470	Predicted periplasmic protein [Function unknown]; Region: COG3904
323097005471	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
323097005472	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
323097005473	trimerization site [polypeptide binding]; other site
323097005474	active site
323097005475	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
323097005476	GTP cyclohydrolase I; Provisional; Region: PLN03044
323097005477	active site
323097005478	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
323097005479	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323097005480	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323097005481	catalytic residue [active]
323097005482	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
323097005483	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
323097005484	putative binding surface; other site
323097005485	active site
323097005486	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323097005487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097005488	active site
323097005489	phosphorylation site [posttranslational modification]
323097005490	intermolecular recognition site; other site
323097005491	dimerization interface [polypeptide binding]; other site
323097005492	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
323097005493	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323097005494	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
323097005495	putative FMN binding site [chemical binding]; other site
323097005496	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
323097005497	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
323097005498	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
323097005499	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
323097005500	active site
323097005501	dimer interface [polypeptide binding]; other site
323097005502	motif 1; other site
323097005503	motif 2; other site
323097005504	motif 3; other site
323097005505	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
323097005506	anticodon binding site; other site
323097005507	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
323097005508	ArsC family; Region: ArsC; pfam03960
323097005509	putative catalytic residues [active]
323097005510	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
323097005511	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
323097005512	Walker A/P-loop; other site
323097005513	ATP binding site [chemical binding]; other site
323097005514	Q-loop/lid; other site
323097005515	ABC transporter signature motif; other site
323097005516	Walker B; other site
323097005517	D-loop; other site
323097005518	H-loop/switch region; other site
323097005519	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
323097005520	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
323097005521	Walker A/P-loop; other site
323097005522	ATP binding site [chemical binding]; other site
323097005523	Q-loop/lid; other site
323097005524	ABC transporter signature motif; other site
323097005525	Walker B; other site
323097005526	D-loop; other site
323097005527	H-loop/switch region; other site
323097005528	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
323097005529	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
323097005530	putative ligand binding site [chemical binding]; other site
323097005531	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
323097005532	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
323097005533	TM-ABC transporter signature motif; other site
323097005534	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
323097005535	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
323097005536	TM-ABC transporter signature motif; other site
323097005537	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
323097005538	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
323097005539	multidrug efflux system protein; Provisional; Region: PRK11431
323097005540	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
323097005541	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
323097005542	G1 box; other site
323097005543	putative GEF interaction site [polypeptide binding]; other site
323097005544	GTP/Mg2+ binding site [chemical binding]; other site
323097005545	Switch I region; other site
323097005546	G2 box; other site
323097005547	G3 box; other site
323097005548	Switch II region; other site
323097005549	G4 box; other site
323097005550	G5 box; other site
323097005551	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
323097005552	NnrU protein; Region: NnrU; pfam07298
323097005553	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
323097005554	oligomerization interface [polypeptide binding]; other site
323097005555	active site
323097005556	metal binding site [ion binding]; metal-binding site
323097005557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
323097005558	GTP-binding protein Der; Reviewed; Region: PRK00093
323097005559	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
323097005560	G1 box; other site
323097005561	GTP/Mg2+ binding site [chemical binding]; other site
323097005562	Switch I region; other site
323097005563	G2 box; other site
323097005564	Switch II region; other site
323097005565	G3 box; other site
323097005566	G4 box; other site
323097005567	G5 box; other site
323097005568	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
323097005569	G1 box; other site
323097005570	GTP/Mg2+ binding site [chemical binding]; other site
323097005571	Switch I region; other site
323097005572	G2 box; other site
323097005573	G3 box; other site
323097005574	Switch II region; other site
323097005575	G4 box; other site
323097005576	G5 box; other site
323097005577	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
323097005578	classical (c) SDRs; Region: SDR_c; cd05233
323097005579	NAD(P) binding site [chemical binding]; other site
323097005580	active site
323097005581	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
323097005582	active site
323097005583	dimer interface [polypeptide binding]; other site
323097005584	Transposase domain (DUF772); Region: DUF772; pfam05598
323097005585	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097005586	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097005587	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
323097005588	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
323097005589	putative active site [active]
323097005590	putative PHP Thumb interface [polypeptide binding]; other site
323097005591	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
323097005592	generic binding surface I; other site
323097005593	generic binding surface II; other site
323097005594	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
323097005595	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
323097005596	rRNA interaction site [nucleotide binding]; other site
323097005597	S8 interaction site; other site
323097005598	putative laminin-1 binding site; other site
323097005599	Uncharacterized conserved protein [Function unknown]; Region: COG3743
323097005600	elongation factor Ts; Provisional; Region: tsf; PRK09377
323097005601	UBA/TS-N domain; Region: UBA; pfam00627
323097005602	Elongation factor TS; Region: EF_TS; pfam00889
323097005603	Elongation factor TS; Region: EF_TS; pfam00889
323097005604	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
323097005605	putative nucleotide binding site [chemical binding]; other site
323097005606	uridine monophosphate binding site [chemical binding]; other site
323097005607	homohexameric interface [polypeptide binding]; other site
323097005608	ribosome recycling factor; Reviewed; Region: frr; PRK00083
323097005609	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
323097005610	hinge region; other site
323097005611	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
323097005612	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
323097005613	catalytic residue [active]
323097005614	putative FPP diphosphate  binding site; other site
323097005615	putative FPP binding hydrophobic cleft; other site
323097005616	dimer interface [polypeptide binding]; other site
323097005617	putative IPP diphosphate binding site; other site
323097005618	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
323097005619	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
323097005620	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
323097005621	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
323097005622	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
323097005623	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
323097005624	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
323097005625	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
323097005626	active site
323097005627	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
323097005628	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
323097005629	putative substrate binding region [chemical binding]; other site
323097005630	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
323097005631	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
323097005632	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
323097005633	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
323097005634	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
323097005635	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
323097005636	Surface antigen; Region: Bac_surface_Ag; pfam01103
323097005637	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
323097005638	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
323097005639	putative trimer interface [polypeptide binding]; other site
323097005640	putative CoA binding site [chemical binding]; other site
323097005641	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
323097005642	trimer interface [polypeptide binding]; other site
323097005643	active site
323097005644	UDP-GlcNAc binding site [chemical binding]; other site
323097005645	lipid binding site [chemical binding]; lipid-binding site
323097005646	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
323097005647	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
323097005648	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
323097005649	active site
323097005650	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
323097005651	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
323097005652	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
323097005653	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
323097005654	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
323097005655	dimer interface [polypeptide binding]; other site
323097005656	active site
323097005657	citrylCoA binding site [chemical binding]; other site
323097005658	NADH binding [chemical binding]; other site
323097005659	cationic pore residues; other site
323097005660	oxalacetate/citrate binding site [chemical binding]; other site
323097005661	coenzyme A binding site [chemical binding]; other site
323097005662	catalytic triad [active]
323097005663	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
323097005664	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
323097005665	HIGH motif; other site
323097005666	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
323097005667	active site
323097005668	KMSKS motif; other site
323097005669	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
323097005670	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323097005671	active site
323097005672	HIGH motif; other site
323097005673	nucleotide binding site [chemical binding]; other site
323097005674	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
323097005675	KMSKS motif; other site
323097005676	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
323097005677	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
323097005678	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
323097005679	Competence protein; Region: Competence; pfam03772
323097005680	Phage-related protein [Function unknown]; Region: COG4695; cl01923
323097005681	Phage portal protein; Region: Phage_portal; pfam04860
323097005682	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
323097005683	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
323097005684	Phage capsid family; Region: Phage_capsid; pfam05065
323097005685	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
323097005686	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
323097005687	oligomerization interface [polypeptide binding]; other site
323097005688	Phage terminase, small subunit; Region: Terminase_4; pfam05119
323097005689	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
323097005690	Phage Terminase; Region: Terminase_1; pfam03354
323097005691	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097005692	active site
323097005693	DNA binding site [nucleotide binding]
323097005694	Int/Topo IB signature motif; other site
323097005695	LexA repressor; Validated; Region: PRK00215
323097005696	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
323097005697	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
323097005698	Catalytic site [active]
323097005699	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
323097005700	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
323097005701	dimer interface [polypeptide binding]; other site
323097005702	putative functional site; other site
323097005703	putative MPT binding site; other site
323097005704	SPW repeat; Region: SPW; pfam03779
323097005705	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
323097005706	trimer interface [polypeptide binding]; other site
323097005707	dimer interface [polypeptide binding]; other site
323097005708	putative active site [active]
323097005709	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
323097005710	active site
323097005711	ribulose/triose binding site [chemical binding]; other site
323097005712	phosphate binding site [ion binding]; other site
323097005713	substrate (anthranilate) binding pocket [chemical binding]; other site
323097005714	product (indole) binding pocket [chemical binding]; other site
323097005715	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
323097005716	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
323097005717	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
323097005718	SurA N-terminal domain; Region: SurA_N_3; cl07813
323097005719	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
323097005720	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
323097005721	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
323097005722	triosephosphate isomerase; Provisional; Region: PRK14565
323097005723	substrate binding site [chemical binding]; other site
323097005724	dimer interface [polypeptide binding]; other site
323097005725	catalytic triad [active]
323097005726	CTP synthetase; Validated; Region: pyrG; PRK05380
323097005727	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
323097005728	Catalytic site [active]
323097005729	active site
323097005730	UTP binding site [chemical binding]; other site
323097005731	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
323097005732	active site
323097005733	putative oxyanion hole; other site
323097005734	catalytic triad [active]
323097005735	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
323097005736	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
323097005737	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
323097005738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097005739	putative substrate translocation pore; other site
323097005740	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
323097005741	enolase; Provisional; Region: eno; PRK00077
323097005742	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
323097005743	dimer interface [polypeptide binding]; other site
323097005744	metal binding site [ion binding]; metal-binding site
323097005745	substrate binding pocket [chemical binding]; other site
323097005746	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
323097005747	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
323097005748	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
323097005749	Predicted flavoprotein [General function prediction only]; Region: COG0431
323097005750	Septum formation initiator; Region: DivIC; pfam04977
323097005751	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
323097005752	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
323097005753	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
323097005754	tetramer interface [polypeptide binding]; other site
323097005755	TPP-binding site [chemical binding]; other site
323097005756	heterodimer interface [polypeptide binding]; other site
323097005757	phosphorylation loop region [posttranslational modification]
323097005758	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
323097005759	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323097005760	E3 interaction surface; other site
323097005761	lipoyl attachment site [posttranslational modification]; other site
323097005762	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
323097005763	alpha subunit interface [polypeptide binding]; other site
323097005764	TPP binding site [chemical binding]; other site
323097005765	heterodimer interface [polypeptide binding]; other site
323097005766	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
323097005767	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
323097005768	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323097005769	E3 interaction surface; other site
323097005770	lipoyl attachment site [posttranslational modification]; other site
323097005771	e3 binding domain; Region: E3_binding; pfam02817
323097005772	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
323097005773	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
323097005774	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
323097005775	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323097005776	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
323097005777	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323097005778	Sel1-like repeats; Region: SEL1; smart00671
323097005779	Sel1 repeat; Region: Sel1; cl02723
323097005780	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
323097005781	putative catalytic site [active]
323097005782	putative phosphate binding site [ion binding]; other site
323097005783	active site
323097005784	metal binding site A [ion binding]; metal-binding site
323097005785	DNA binding site [nucleotide binding]
323097005786	putative AP binding site [nucleotide binding]; other site
323097005787	putative metal binding site B [ion binding]; other site
323097005788	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
323097005789	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
323097005790	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
323097005791	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
323097005792	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
323097005793	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
323097005794	active site
323097005795	HIGH motif; other site
323097005796	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323097005797	KMSK motif region; other site
323097005798	tRNA binding surface [nucleotide binding]; other site
323097005799	DALR anticodon binding domain; Region: DALR_1; smart00836
323097005800	anticodon binding site; other site
323097005801	Sporulation related domain; Region: SPOR; pfam05036
323097005802	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
323097005803	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
323097005804	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
323097005805	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
323097005806	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
323097005807	DNA gyrase subunit A; Validated; Region: PRK05560
323097005808	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
323097005809	CAP-like domain; other site
323097005810	active site
323097005811	primary dimer interface [polypeptide binding]; other site
323097005812	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323097005813	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323097005814	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323097005815	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323097005816	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323097005817	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
323097005818	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
323097005819	active site
323097005820	(T/H)XGH motif; other site
323097005821	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
323097005822	active site
323097005823	Gram-negative bacterial tonB protein; Region: TonB; cl10048
323097005824	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
323097005825	active site
323097005826	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
323097005827	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
323097005828	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
323097005829	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
323097005830	C4-type Zn-finger protein [General function prediction only]; Region: COG1779
323097005831	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
323097005832	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
323097005833	dimer interface [polypeptide binding]; other site
323097005834	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097005835	catalytic residue [active]
323097005836	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
323097005837	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
323097005838	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
323097005839	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323097005840	active site
323097005841	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
323097005842	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
323097005843	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
323097005844	Substrate binding site; other site
323097005845	Mg++ binding site; other site
323097005846	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
323097005847	active site
323097005848	substrate binding site [chemical binding]; other site
323097005849	CoA binding site [chemical binding]; other site
323097005850	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
323097005851	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
323097005852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097005853	S-adenosylmethionine binding site [chemical binding]; other site
323097005854	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
323097005855	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
323097005856	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
323097005857	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
323097005858	seryl-tRNA synthetase; Provisional; Region: PRK05431
323097005859	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
323097005860	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
323097005861	dimer interface [polypeptide binding]; other site
323097005862	active site
323097005863	motif 1; other site
323097005864	motif 2; other site
323097005865	motif 3; other site
323097005866	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
323097005867	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323097005868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097005869	active site
323097005870	phosphorylation site [posttranslational modification]
323097005871	intermolecular recognition site; other site
323097005872	dimerization interface [polypeptide binding]; other site
323097005873	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
323097005874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097005875	S-adenosylmethionine binding site [chemical binding]; other site
323097005876	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
323097005877	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
323097005878	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
323097005879	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
323097005880	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
323097005881	Peptidase family M23; Region: Peptidase_M23; pfam01551
323097005882	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
323097005883	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
323097005884	Chromate transporter; Region: Chromate_transp; pfam02417
323097005885	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
323097005886	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097005887	Walker A motif; other site
323097005888	ATP binding site [chemical binding]; other site
323097005889	Walker B motif; other site
323097005890	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
323097005891	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
323097005892	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
323097005893	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
323097005894	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
323097005895	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
323097005896	Protein export membrane protein; Region: SecD_SecF; pfam02355
323097005897	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
323097005898	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
323097005899	substrate binding pocket [chemical binding]; other site
323097005900	aspartate-rich region 2; other site
323097005901	substrate-Mg2+ binding site; other site
323097005902	serine/threonine protein kinase; Provisional; Region: PRK09188
323097005903	serine/threonine protein kinase; Provisional; Region: PRK12274
323097005904	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
323097005905	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
323097005906	Glucose inhibited division protein A; Region: GIDA; pfam01134
323097005907	Predicted integral membrane protein [Function unknown]; Region: COG5473
323097005908	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
323097005909	Predicted acetyltransferase [General function prediction only]; Region: COG2388
323097005910	Predicted acetyltransferase [General function prediction only]; Region: COG2388
323097005911	NADH dehydrogenase; Validated; Region: PRK08183
323097005912	FecR protein; Region: FecR; pfam04773
323097005913	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
323097005914	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
323097005915	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
323097005916	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
323097005917	dimer interface [polypeptide binding]; other site
323097005918	active site
323097005919	glycine-pyridoxal phosphate binding site [chemical binding]; other site
323097005920	folate binding site [chemical binding]; other site
323097005921	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
323097005922	ATP cone domain; Region: ATP-cone; pfam03477
323097005923	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
323097005924	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
323097005925	catalytic motif [active]
323097005926	Zn binding site [ion binding]; other site
323097005927	RibD C-terminal domain; Region: RibD_C; cl17279
323097005928	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
323097005929	Lumazine binding domain; Region: Lum_binding; pfam00677
323097005930	Lumazine binding domain; Region: Lum_binding; pfam00677
323097005931	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
323097005932	homopentamer interface [polypeptide binding]; other site
323097005933	active site
323097005934	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
323097005935	putative RNA binding site [nucleotide binding]; other site
323097005936	thiamine-monophosphate kinase; Region: thiL; TIGR01379
323097005937	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
323097005938	ATP binding site [chemical binding]; other site
323097005939	dimerization interface [polypeptide binding]; other site
323097005940	Transposase domain (DUF772); Region: DUF772; pfam05598
323097005941	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097005942	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097005943	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
323097005944	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
323097005945	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
323097005946	AMIN domain; Region: AMIN; pfam11741
323097005947	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
323097005948	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
323097005949	active site
323097005950	metal binding site [ion binding]; metal-binding site
323097005951	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
323097005952	Transglycosylase; Region: Transgly; pfam00912
323097005953	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
323097005954	peptide chain release factor 2; Provisional; Region: PRK07342
323097005955	This domain is found in peptide chain release factors; Region: PCRF; smart00937
323097005956	RF-1 domain; Region: RF-1; pfam00472
323097005957	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
323097005958	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
323097005959	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
323097005960	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
323097005961	HIGH motif; other site
323097005962	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
323097005963	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
323097005964	active site
323097005965	KMSKS motif; other site
323097005966	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
323097005967	tRNA binding surface [nucleotide binding]; other site
323097005968	anticodon binding site; other site
323097005969	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
323097005970	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
323097005971	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
323097005972	DNA binding site [nucleotide binding]
323097005973	active site
323097005974	lipoyl synthase; Provisional; Region: PRK05481
323097005975	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097005976	FeS/SAM binding site; other site
323097005977	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
323097005978	putative coenzyme Q binding site [chemical binding]; other site
323097005979	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
323097005980	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
323097005981	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
323097005982	substrate binding site; other site
323097005983	dimer interface; other site
323097005984	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
323097005985	homotrimer interaction site [polypeptide binding]; other site
323097005986	zinc binding site [ion binding]; other site
323097005987	CDP-binding sites; other site
323097005988	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
323097005989	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
323097005990	FMN binding site [chemical binding]; other site
323097005991	active site
323097005992	catalytic residues [active]
323097005993	substrate binding site [chemical binding]; other site
323097005994	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
323097005995	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097005996	putative active site [active]
323097005997	heme pocket [chemical binding]; other site
323097005998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097005999	dimer interface [polypeptide binding]; other site
323097006000	phosphorylation site [posttranslational modification]
323097006001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097006002	ATP binding site [chemical binding]; other site
323097006003	Mg2+ binding site [ion binding]; other site
323097006004	G-X-G motif; other site
323097006005	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
323097006006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097006007	active site
323097006008	phosphorylation site [posttranslational modification]
323097006009	intermolecular recognition site; other site
323097006010	dimerization interface [polypeptide binding]; other site
323097006011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097006012	Walker A motif; other site
323097006013	ATP binding site [chemical binding]; other site
323097006014	Walker B motif; other site
323097006015	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
323097006016	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
323097006017	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
323097006018	dimerization interface [polypeptide binding]; other site
323097006019	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097006020	putative active site [active]
323097006021	heme pocket [chemical binding]; other site
323097006022	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097006023	dimer interface [polypeptide binding]; other site
323097006024	phosphorylation site [posttranslational modification]
323097006025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097006026	ATP binding site [chemical binding]; other site
323097006027	Mg2+ binding site [ion binding]; other site
323097006028	G-X-G motif; other site
323097006029	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
323097006030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097006031	active site
323097006032	phosphorylation site [posttranslational modification]
323097006033	intermolecular recognition site; other site
323097006034	dimerization interface [polypeptide binding]; other site
323097006035	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097006036	Walker A motif; other site
323097006037	ATP binding site [chemical binding]; other site
323097006038	Walker B motif; other site
323097006039	arginine finger; other site
323097006040	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
323097006041	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
323097006042	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
323097006043	homodimer interface [polypeptide binding]; other site
323097006044	substrate-cofactor binding pocket; other site
323097006045	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097006046	catalytic residue [active]
323097006047	bacterial Hfq-like; Region: Hfq; cd01716
323097006048	hexamer interface [polypeptide binding]; other site
323097006049	Sm1 motif; other site
323097006050	RNA binding site [nucleotide binding]; other site
323097006051	Sm2 motif; other site
323097006052	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
323097006053	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
323097006054	HflX GTPase family; Region: HflX; cd01878
323097006055	G1 box; other site
323097006056	GTP/Mg2+ binding site [chemical binding]; other site
323097006057	Switch I region; other site
323097006058	G2 box; other site
323097006059	G3 box; other site
323097006060	Switch II region; other site
323097006061	G4 box; other site
323097006062	G5 box; other site
323097006063	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
323097006064	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
323097006065	tetramerization interface [polypeptide binding]; other site
323097006066	NAD(P) binding site [chemical binding]; other site
323097006067	catalytic residues [active]
323097006068	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
323097006069	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
323097006070	homodimer interface [polypeptide binding]; other site
323097006071	metal binding site [ion binding]; metal-binding site
323097006072	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
323097006073	homodimer interface [polypeptide binding]; other site
323097006074	active site
323097006075	putative chemical substrate binding site [chemical binding]; other site
323097006076	metal binding site [ion binding]; metal-binding site
323097006077	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
323097006078	Ligand Binding Site [chemical binding]; other site
323097006079	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
323097006080	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
323097006081	lipoyl-biotinyl attachment site [posttranslational modification]; other site
323097006082	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097006083	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
323097006084	YtkA-like; Region: YtkA; pfam13115
323097006085	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
323097006086	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097006087	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
323097006088	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
323097006089	putative DNA binding site [nucleotide binding]; other site
323097006090	putative Zn2+ binding site [ion binding]; other site
323097006091	TniQ; Region: TniQ; pfam06527
323097006092	AAA domain; Region: AAA_22; pfam13401
323097006093	Integrase core domain; Region: rve; pfam00665
323097006094	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097006095	active site
323097006096	Int/Topo IB signature motif; other site
323097006097	DNA binding site [nucleotide binding]
323097006098	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
323097006099	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
323097006100	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097006101	Major Facilitator Superfamily; Region: MFS_1; pfam07690
323097006102	putative substrate translocation pore; other site
323097006103	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
323097006104	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
323097006105	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
323097006106	methionine gamma-lyase; Validated; Region: PRK07049
323097006107	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
323097006108	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323097006109	Nuclease-related domain; Region: NERD; pfam08378
323097006110	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
323097006111	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
323097006112	Sulfate transporter family; Region: Sulfate_transp; pfam00916
323097006113	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
323097006114	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097006115	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097006116	protein binding site [polypeptide binding]; other site
323097006117	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097006118	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
323097006119	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097006120	protein binding site [polypeptide binding]; other site
323097006121	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
323097006122	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
323097006123	DNA binding residues [nucleotide binding]
323097006124	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
323097006125	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
323097006126	Predicted membrane protein [Function unknown]; Region: COG3212
323097006127	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
323097006128	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097006129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097006130	active site
323097006131	phosphorylation site [posttranslational modification]
323097006132	intermolecular recognition site; other site
323097006133	dimerization interface [polypeptide binding]; other site
323097006134	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097006135	DNA binding site [nucleotide binding]
323097006136	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097006137	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097006138	ATP binding site [chemical binding]; other site
323097006139	Mg2+ binding site [ion binding]; other site
323097006140	G-X-G motif; other site
323097006141	Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154
323097006142	putative homodimer interface [polypeptide binding]; other site
323097006143	putative homotetramer interface [polypeptide binding]; other site
323097006144	putative metal binding site [ion binding]; other site
323097006145	putative homodimer-homodimer interface [polypeptide binding]; other site
323097006146	putative allosteric switch controlling residues; other site
323097006147	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
323097006148	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097006149	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
323097006150	Cupin domain; Region: Cupin_2; cl17218
323097006151	Acetokinase family; Region: Acetate_kinase; cl17229
323097006152	propionate/acetate kinase; Provisional; Region: PRK12379
323097006153	putative phosphoketolase; Provisional; Region: PRK05261
323097006154	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
323097006155	TPP-binding site; other site
323097006156	XFP C-terminal domain; Region: XFP_C; pfam09363
323097006157	FOG: CBS domain [General function prediction only]; Region: COG0517
323097006158	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
323097006159	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
323097006160	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
323097006161	Beta-Casp domain; Region: Beta-Casp; smart01027
323097006162	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
323097006163	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
323097006164	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
323097006165	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323097006166	active site
323097006167	thymidine phosphorylase; Provisional; Region: PRK04350
323097006168	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
323097006169	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
323097006170	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
323097006171	MgtC family; Region: MgtC; pfam02308
323097006172	Predicted membrane protein [Function unknown]; Region: COG3174
323097006173	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
323097006174	FOG: CBS domain [General function prediction only]; Region: COG0517
323097006175	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
323097006176	BON domain; Region: BON; pfam04972
323097006177	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
323097006178	FMN binding site [chemical binding]; other site
323097006179	dimer interface [polypeptide binding]; other site
323097006180	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097006181	Response regulator receiver domain; Region: Response_reg; pfam00072
323097006182	active site
323097006183	phosphorylation site [posttranslational modification]
323097006184	intermolecular recognition site; other site
323097006185	dimerization interface [polypeptide binding]; other site
323097006186	response regulator FixJ; Provisional; Region: fixJ; PRK09390
323097006187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097006188	active site
323097006189	phosphorylation site [posttranslational modification]
323097006190	intermolecular recognition site; other site
323097006191	dimerization interface [polypeptide binding]; other site
323097006192	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323097006193	DNA binding residues [nucleotide binding]
323097006194	dimerization interface [polypeptide binding]; other site
323097006195	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097006196	PAS fold; Region: PAS_3; pfam08447
323097006197	putative active site [active]
323097006198	heme pocket [chemical binding]; other site
323097006199	PAS domain S-box; Region: sensory_box; TIGR00229
323097006200	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097006201	putative active site [active]
323097006202	heme pocket [chemical binding]; other site
323097006203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097006204	dimer interface [polypeptide binding]; other site
323097006205	phosphorylation site [posttranslational modification]
323097006206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097006207	ATP binding site [chemical binding]; other site
323097006208	Mg2+ binding site [ion binding]; other site
323097006209	G-X-G motif; other site
323097006210	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
323097006211	BON domain; Region: BON; pfam04972
323097006212	BON domain; Region: BON; pfam04972
323097006213	Domain of unknown function DUF302; Region: DUF302; pfam03625
323097006214	FOG: CBS domain [General function prediction only]; Region: COG0517
323097006215	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
323097006216	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
323097006217	Ligand Binding Site [chemical binding]; other site
323097006218	CHAD domain; Region: CHAD; pfam05235
323097006219	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
323097006220	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
323097006221	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
323097006222	AAA domain; Region: AAA_33; pfam13671
323097006223	active site
323097006224	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
323097006225	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
323097006226	putative NAD(P) binding site [chemical binding]; other site
323097006227	putative substrate binding site [chemical binding]; other site
323097006228	catalytic Zn binding site [ion binding]; other site
323097006229	structural Zn binding site [ion binding]; other site
323097006230	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323097006231	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
323097006232	putative dimer interface [polypeptide binding]; other site
323097006233	FOG: CBS domain [General function prediction only]; Region: COG0517
323097006234	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
323097006235	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
323097006236	CoA binding domain; Region: CoA_binding_2; pfam13380
323097006237	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
323097006238	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
323097006239	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
323097006240	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323097006241	Coenzyme A binding pocket [chemical binding]; other site
323097006242	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
323097006243	anti sigma factor interaction site; other site
323097006244	regulatory phosphorylation site [posttranslational modification]; other site
323097006245	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
323097006246	Permease; Region: Permease; pfam02405
323097006247	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
323097006248	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
323097006249	Walker A/P-loop; other site
323097006250	ATP binding site [chemical binding]; other site
323097006251	Q-loop/lid; other site
323097006252	ABC transporter signature motif; other site
323097006253	Walker B; other site
323097006254	D-loop; other site
323097006255	H-loop/switch region; other site
323097006256	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
323097006257	mce related protein; Region: MCE; pfam02470
323097006258	Protein of unknown function (DUF330); Region: DUF330; cl01135
323097006259	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323097006260	Cytochrome c; Region: Cytochrom_C; pfam00034
323097006261	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
323097006262	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323097006263	Ligand Binding Site [chemical binding]; other site
323097006264	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
323097006265	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
323097006266	catalytic Zn binding site [ion binding]; other site
323097006267	structural Zn binding site [ion binding]; other site
323097006268	NAD(P) binding site [chemical binding]; other site
323097006269	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
323097006270	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097006271	S-adenosylmethionine binding site [chemical binding]; other site
323097006272	Erythromycin esterase; Region: Erythro_esteras; pfam05139
323097006273	Protein required for attachment to host cells; Region: Host_attach; pfam10116
323097006274	FOG: CBS domain [General function prediction only]; Region: COG0517
323097006275	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
323097006276	BON domain; Region: BON; pfam04972
323097006277	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323097006278	Ligand Binding Site [chemical binding]; other site
323097006279	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
323097006280	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
323097006281	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
323097006282	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
323097006283	Chromate transporter; Region: Chromate_transp; pfam02417
323097006284	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097006285	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097006286	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097006287	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
323097006288	Cytochrome c; Region: Cytochrom_C; pfam00034
323097006289	FOG: CBS domain [General function prediction only]; Region: COG0517
323097006290	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
323097006291	BON domain; Region: BON; pfam04972
323097006292	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323097006293	Ligand Binding Site [chemical binding]; other site
323097006294	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
323097006295	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323097006296	Soluble P-type ATPase [General function prediction only]; Region: COG4087
323097006297	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
323097006298	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323097006299	ligand binding site [chemical binding]; other site
323097006300	flexible hinge region; other site
323097006301	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
323097006302	putative switch regulator; other site
323097006303	non-specific DNA interactions [nucleotide binding]; other site
323097006304	DNA binding site [nucleotide binding]
323097006305	sequence specific DNA binding site [nucleotide binding]; other site
323097006306	putative cAMP binding site [chemical binding]; other site
323097006307	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097006308	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097006309	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097006310	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097006311	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097006312	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097006313	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097006314	Ion channel; Region: Ion_trans_2; pfam07885
323097006315	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
323097006316	PRC-barrel domain; Region: PRC; pfam05239
323097006317	Transposase; Region: HTH_Tnp_1; cl17663
323097006318	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323097006319	Transposase, Mutator family; Region: Transposase_mut; pfam00872
323097006320	Staphylococcal nuclease homologues; Region: SNc; smart00318
323097006321	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
323097006322	Catalytic site; other site
323097006323	HEPN domain; Region: HEPN; cl00824
323097006324	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
323097006325	Competence protein CoiA-like family; Region: CoiA; cl11541
323097006326	RES domain; Region: RES; smart00953
323097006327	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
323097006328	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097006329	Walker A motif; other site
323097006330	ATP binding site [chemical binding]; other site
323097006331	Walker B motif; other site
323097006332	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
323097006333	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
323097006334	active site
323097006335	metal binding site [ion binding]; metal-binding site
323097006336	RES domain; Region: RES; smart00953
323097006337	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097006338	ATP binding site [chemical binding]; other site
323097006339	putative Mg++ binding site [ion binding]; other site
323097006340	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
323097006341	nucleotide binding region [chemical binding]; other site
323097006342	ATP-binding site [chemical binding]; other site
323097006343	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
323097006344	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
323097006345	nudix motif; other site
323097006346	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
323097006347	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
323097006348	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097006349	Walker A/P-loop; other site
323097006350	ATP binding site [chemical binding]; other site
323097006351	AAA domain; Region: AAA_21; pfam13304
323097006352	Part of AAA domain; Region: AAA_19; pfam13245
323097006353	Family description; Region: UvrD_C_2; pfam13538
323097006354	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
323097006355	Part of AAA domain; Region: AAA_19; pfam13245
323097006356	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
323097006357	Family description; Region: UvrD_C_2; pfam13538
323097006358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097006359	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097006360	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097006361	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
323097006362	tellurium resistance terB-like protein; Region: terB_like; cl11965
323097006363	metal binding site [ion binding]; metal-binding site
323097006364	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
323097006365	AAA ATPase domain; Region: AAA_16; pfam13191
323097006366	DEAD-like helicases superfamily; Region: DEXDc; smart00487
323097006367	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097006368	ATP binding site [chemical binding]; other site
323097006369	putative Mg++ binding site [ion binding]; other site
323097006370	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
323097006371	nucleotide binding region [chemical binding]; other site
323097006372	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097006373	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097006374	Uncharacterized conserved protein [Function unknown]; Region: COG1742
323097006375	acyl-CoA synthetase; Validated; Region: PRK08162
323097006376	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
323097006377	acyl-activating enzyme (AAE) consensus motif; other site
323097006378	putative active site [active]
323097006379	AMP binding site [chemical binding]; other site
323097006380	putative CoA binding site [chemical binding]; other site
323097006381	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
323097006382	putative hydrolase; Provisional; Region: PRK02113
323097006383	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
323097006384	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
323097006385	active site
323097006386	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
323097006387	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
323097006388	active site
323097006389	HIGH motif; other site
323097006390	KMSKS motif; other site
323097006391	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
323097006392	tRNA binding surface [nucleotide binding]; other site
323097006393	anticodon binding site; other site
323097006394	DNA polymerase III subunit delta'; Validated; Region: PRK07471
323097006395	DNA polymerase III subunit delta'; Validated; Region: PRK08485
323097006396	thymidylate kinase; Validated; Region: tmk; PRK00698
323097006397	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
323097006398	TMP-binding site; other site
323097006399	ATP-binding site [chemical binding]; other site
323097006400	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
323097006401	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
323097006402	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
323097006403	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
323097006404	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
323097006405	integrase; Provisional; Region: PRK09692
323097006406	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
323097006407	active site
323097006408	Int/Topo IB signature motif; other site
323097006409	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
323097006410	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
323097006411	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
323097006412	Phage terminase, small subunit; Region: Terminase_4; pfam05119
323097006413	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
323097006414	oligomerization interface [polypeptide binding]; other site
323097006415	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
323097006416	Phage capsid family; Region: Phage_capsid; pfam05065
323097006417	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
323097006418	Phage-related protein [Function unknown]; Region: COG4695; cl01923
323097006419	Phage portal protein; Region: Phage_portal; pfam04860
323097006420	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323097006421	Walker A motif; other site
323097006422	ATP binding site [chemical binding]; other site
323097006423	Walker B motif; other site
323097006424	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
323097006425	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097006426	DNA-binding site [nucleotide binding]; DNA binding site
323097006427	RNA-binding motif; other site
323097006428	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
323097006429	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
323097006430	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
323097006431	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
323097006432	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
323097006433	putative active site [active]
323097006434	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
323097006435	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
323097006436	NADP binding site [chemical binding]; other site
323097006437	dimer interface [polypeptide binding]; other site
323097006438	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
323097006439	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
323097006440	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
323097006441	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
323097006442	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323097006443	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
323097006444	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
323097006445	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
323097006446	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
323097006447	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
323097006448	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
323097006449	acyl-activating enzyme (AAE) consensus motif; other site
323097006450	active site
323097006451	CoA binding site [chemical binding]; other site
323097006452	AMP binding site [chemical binding]; other site
323097006453	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323097006454	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
323097006455	nucleotidyl binding site; other site
323097006456	metal binding site [ion binding]; metal-binding site
323097006457	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
323097006458	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
323097006459	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097006460	ATP binding site [chemical binding]; other site
323097006461	putative Mg++ binding site [ion binding]; other site
323097006462	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097006463	nucleotide binding region [chemical binding]; other site
323097006464	ATP-binding site [chemical binding]; other site
323097006465	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
323097006466	Uncharacterized conserved protein [Function unknown]; Region: COG2938
323097006467	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
323097006468	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
323097006469	generic binding surface II; other site
323097006470	ssDNA binding site; other site
323097006471	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097006472	ATP binding site [chemical binding]; other site
323097006473	putative Mg++ binding site [ion binding]; other site
323097006474	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097006475	nucleotide binding region [chemical binding]; other site
323097006476	ATP-binding site [chemical binding]; other site
323097006477	Uncharacterized conserved protein [Function unknown]; Region: COG2928
323097006478	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
323097006479	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
323097006480	glutaminase active site [active]
323097006481	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
323097006482	dimer interface [polypeptide binding]; other site
323097006483	active site
323097006484	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
323097006485	dimer interface [polypeptide binding]; other site
323097006486	active site
323097006487	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
323097006488	DTW domain; Region: DTW; cl01221
323097006489	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
323097006490	Protein export membrane protein; Region: SecD_SecF; cl14618
323097006491	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
323097006492	Protein export membrane protein; Region: SecD_SecF; cl14618
323097006493	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
323097006494	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097006495	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097006496	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
323097006497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
323097006498	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
323097006499	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
323097006500	dimer interface [polypeptide binding]; other site
323097006501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097006502	catalytic residue [active]
323097006503	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
323097006504	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
323097006505	Walker A/P-loop; other site
323097006506	ATP binding site [chemical binding]; other site
323097006507	Q-loop/lid; other site
323097006508	ABC transporter signature motif; other site
323097006509	Walker B; other site
323097006510	D-loop; other site
323097006511	H-loop/switch region; other site
323097006512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097006513	dimer interface [polypeptide binding]; other site
323097006514	conserved gate region; other site
323097006515	putative PBP binding loops; other site
323097006516	ABC-ATPase subunit interface; other site
323097006517	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
323097006518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097006519	conserved gate region; other site
323097006520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097006521	dimer interface [polypeptide binding]; other site
323097006522	conserved gate region; other site
323097006523	putative PBP binding loops; other site
323097006524	ABC-ATPase subunit interface; other site
323097006525	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
323097006526	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
323097006527	substrate binding pocket [chemical binding]; other site
323097006528	membrane-bound complex binding site; other site
323097006529	hinge residues; other site
323097006530	cystathionine beta-lyase; Provisional; Region: PRK05967
323097006531	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
323097006532	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323097006533	catalytic residue [active]
323097006534	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
323097006535	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
323097006536	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
323097006537	PhoU domain; Region: PhoU; pfam01895
323097006538	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
323097006539	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
323097006540	Ligand binding site; other site
323097006541	Putative Catalytic site; other site
323097006542	DXD motif; other site
323097006543	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
323097006544	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
323097006545	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
323097006546	Transglycosylase; Region: Transgly; pfam00912
323097006547	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
323097006548	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
323097006549	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
323097006550	MG2 domain; Region: A2M_N; pfam01835
323097006551	Alpha-2-macroglobulin family; Region: A2M; pfam00207
323097006552	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
323097006553	surface patch; other site
323097006554	thioester region; other site
323097006555	specificity defining residues; other site
323097006556	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
323097006557	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
323097006558	dimer interface [polypeptide binding]; other site
323097006559	ssDNA binding site [nucleotide binding]; other site
323097006560	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323097006561	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
323097006562	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
323097006563	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
323097006564	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
323097006565	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
323097006566	BA14K-like protein; Region: BA14K; pfam07886
323097006567	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
323097006568	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
323097006569	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
323097006570	Transcriptional regulator; Region: Transcrip_reg; cl00361
323097006571	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
323097006572	active site
323097006573	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
323097006574	TSCPD domain; Region: TSCPD; pfam12637
323097006575	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
323097006576	Integrase core domain; Region: rve; pfam00665
323097006577	Integrase core domain; Region: rve_3; cl15866
323097006578	AAA ATPase domain; Region: AAA_16; pfam13191
323097006579	AAA domain; Region: AAA_22; pfam13401
323097006580	TniQ; Region: TniQ; pfam06527
323097006581	SEC-C motif; Region: SEC-C; pfam02810
323097006582	TIR domain; Region: TIR_2; pfam13676
323097006583	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
323097006584	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
323097006585	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
323097006586	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
323097006587	nucleotide binding site [chemical binding]; other site
323097006588	putative S-transferase; Provisional; Region: PRK11752
323097006589	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
323097006590	C-terminal domain interface [polypeptide binding]; other site
323097006591	GSH binding site (G-site) [chemical binding]; other site
323097006592	dimer interface [polypeptide binding]; other site
323097006593	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
323097006594	dimer interface [polypeptide binding]; other site
323097006595	N-terminal domain interface [polypeptide binding]; other site
323097006596	active site
323097006597	short chain dehydrogenase; Provisional; Region: PRK12828
323097006598	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097006599	NAD(P) binding site [chemical binding]; other site
323097006600	active site
323097006601	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
323097006602	active site 1 [active]
323097006603	dimer interface [polypeptide binding]; other site
323097006604	active site 2 [active]
323097006605	Uncharacterized conserved protein [Function unknown]; Region: COG5482
323097006606	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
323097006607	CreA protein; Region: CreA; pfam05981
323097006608	hypothetical protein; Provisional; Region: PRK06132
323097006609	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097006610	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
323097006611	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
323097006612	NodB motif; other site
323097006613	active site
323097006614	catalytic site [active]
323097006615	metal binding site [ion binding]; metal-binding site
323097006616	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
323097006617	folate binding site [chemical binding]; other site
323097006618	NADP+ binding site [chemical binding]; other site
323097006619	Predicted membrane protein [Function unknown]; Region: COG2259
323097006620	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
323097006621	Malic enzyme, N-terminal domain; Region: malic; pfam00390
323097006622	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
323097006623	putative NAD(P) binding site [chemical binding]; other site
323097006624	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
323097006625	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
323097006626	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
323097006627	dimer interface [polypeptide binding]; other site
323097006628	anticodon binding site; other site
323097006629	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
323097006630	homodimer interface [polypeptide binding]; other site
323097006631	motif 1; other site
323097006632	active site
323097006633	motif 2; other site
323097006634	GAD domain; Region: GAD; pfam02938
323097006635	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323097006636	active site
323097006637	motif 3; other site
323097006638	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
323097006639	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
323097006640	catalytic site [active]
323097006641	putative active site [active]
323097006642	putative substrate binding site [chemical binding]; other site
323097006643	HRDC domain; Region: HRDC; pfam00570
323097006644	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
323097006645	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
323097006646	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
323097006647	[2Fe-2S] cluster binding site [ion binding]; other site
323097006648	exopolyphosphatase; Region: exo_poly_only; TIGR03706
323097006649	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
323097006650	polyphosphate kinase; Provisional; Region: PRK05443
323097006651	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
323097006652	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
323097006653	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
323097006654	putative domain interface [polypeptide binding]; other site
323097006655	putative active site [active]
323097006656	catalytic site [active]
323097006657	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
323097006658	putative domain interface [polypeptide binding]; other site
323097006659	putative active site [active]
323097006660	catalytic site [active]
323097006661	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
323097006662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
323097006663	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
323097006664	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
323097006665	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
323097006666	dimerization interface [polypeptide binding]; other site
323097006667	putative ATP binding site [chemical binding]; other site
323097006668	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
323097006669	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
323097006670	active site
323097006671	substrate binding site [chemical binding]; other site
323097006672	cosubstrate binding site; other site
323097006673	catalytic site [active]
323097006674	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097006675	DNA-binding site [nucleotide binding]; DNA binding site
323097006676	RNA-binding motif; other site
323097006677	Integral membrane protein TerC family; Region: TerC; cl10468
323097006678	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
323097006679	active site
323097006680	multimer interface [polypeptide binding]; other site
323097006681	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
323097006682	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323097006683	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
323097006684	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
323097006685	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
323097006686	carboxyltransferase (CT) interaction site; other site
323097006687	biotinylation site [posttranslational modification]; other site
323097006688	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
323097006689	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
323097006690	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
323097006691	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
323097006692	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
323097006693	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
323097006694	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
323097006695	Int/Topo IB signature motif; other site
323097006696	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323097006697	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097006698	Phage portal protein; Region: Phage_portal; pfam04860
323097006699	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
323097006700	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097006701	DNA-binding site [nucleotide binding]; DNA binding site
323097006702	RNA-binding motif; other site
323097006703	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097006704	DNA-binding site [nucleotide binding]; DNA binding site
323097006705	RNA-binding motif; other site
323097006706	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097006707	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
323097006708	dimer interface [polypeptide binding]; other site
323097006709	active site
323097006710	metal binding site [ion binding]; metal-binding site
323097006711	glutathione binding site [chemical binding]; other site
323097006712	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097006713	DNA-binding site [nucleotide binding]; DNA binding site
323097006714	RNA-binding motif; other site
323097006715	Phage portal protein; Region: Phage_portal; pfam04860
323097006716	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
323097006717	Phage capsid family; Region: Phage_capsid; pfam05065
323097006718	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
323097006719	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
323097006720	polymerase nucleotide-binding site; other site
323097006721	DNA-binding residues [nucleotide binding]; DNA binding site
323097006722	nucleotide binding site [chemical binding]; other site
323097006723	primase nucleotide-binding site [nucleotide binding]; other site
323097006724	Virulence-associated protein E; Region: VirE; pfam05272
323097006725	Helix-turn-helix domain; Region: HTH_17; pfam12728
323097006726	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
323097006727	active site
323097006728	catalytic residues [active]
323097006729	DNA binding site [nucleotide binding]
323097006730	Int/Topo IB signature motif; other site
323097006731	Transposase domain (DUF772); Region: DUF772; pfam05598
323097006732	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097006733	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097006734	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
323097006735	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
323097006736	active site
323097006737	hypothetical protein; Validated; Region: PRK06033
323097006738	lipoate-protein ligase B; Provisional; Region: PRK14341
323097006739	acylphosphatase; Provisional; Region: PRK14421
323097006740	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
323097006741	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323097006742	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
323097006743	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
323097006744	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
323097006745	carboxyltransferase (CT) interaction site; other site
323097006746	biotinylation site [posttranslational modification]; other site
323097006747	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
323097006748	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
323097006749	dimer interface [polypeptide binding]; other site
323097006750	decamer (pentamer of dimers) interface [polypeptide binding]; other site
323097006751	catalytic triad [active]
323097006752	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
323097006753	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
323097006754	substrate binding site [chemical binding]; other site
323097006755	catalytic Zn binding site [ion binding]; other site
323097006756	NAD binding site [chemical binding]; other site
323097006757	structural Zn binding site [ion binding]; other site
323097006758	dimer interface [polypeptide binding]; other site
323097006759	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
323097006760	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
323097006761	cyclase homology domain; Region: CHD; cd07302
323097006762	nucleotidyl binding site; other site
323097006763	metal binding site [ion binding]; metal-binding site
323097006764	dimer interface [polypeptide binding]; other site
323097006765	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097006766	Tetratricopeptide repeat; Region: TPR_16; pfam13432
323097006767	binding surface
323097006768	TPR motif; other site
323097006769	Protein of unknown function (DUF2860); Region: DUF2860; pfam11059
323097006770	PRC-barrel domain; Region: PRC; pfam05239
323097006771	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
323097006772	HAMP domain; Region: HAMP; pfam00672
323097006773	PAS domain S-box; Region: sensory_box; TIGR00229
323097006774	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097006775	putative active site [active]
323097006776	heme pocket [chemical binding]; other site
323097006777	PAS fold; Region: PAS_4; pfam08448
323097006778	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097006779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097006780	ATP binding site [chemical binding]; other site
323097006781	Mg2+ binding site [ion binding]; other site
323097006782	G-X-G motif; other site
323097006783	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
323097006784	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
323097006785	dimer interface [polypeptide binding]; other site
323097006786	PYR/PP interface [polypeptide binding]; other site
323097006787	TPP binding site [chemical binding]; other site
323097006788	substrate binding site [chemical binding]; other site
323097006789	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
323097006790	TPP-binding site; other site
323097006791	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
323097006792	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
323097006793	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
323097006794	tetramer interface [polypeptide binding]; other site
323097006795	active site
323097006796	Mg2+/Mn2+ binding site [ion binding]; other site
323097006797	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
323097006798	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
323097006799	aspartate aminotransferase; Provisional; Region: PRK05764
323097006800	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323097006801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097006802	homodimer interface [polypeptide binding]; other site
323097006803	catalytic residue [active]
323097006804	Peptidase family M48; Region: Peptidase_M48; cl12018
323097006805	Tetratricopeptide repeat; Region: TPR_16; pfam13432
323097006806	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
323097006807	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
323097006808	catalytic residues [active]
323097006809	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
323097006810	Dehydroquinase class II; Region: DHquinase_II; pfam01220
323097006811	trimer interface [polypeptide binding]; other site
323097006812	active site
323097006813	dimer interface [polypeptide binding]; other site
323097006814	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
323097006815	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
323097006816	carboxyltransferase (CT) interaction site; other site
323097006817	biotinylation site [posttranslational modification]; other site
323097006818	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
323097006819	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323097006820	ATP-grasp domain; Region: ATP-grasp_4; cl17255
323097006821	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
323097006822	CHASE3 domain; Region: CHASE3; pfam05227
323097006823	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097006824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097006825	ATP binding site [chemical binding]; other site
323097006826	Mg2+ binding site [ion binding]; other site
323097006827	G-X-G motif; other site
323097006828	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323097006829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097006830	active site
323097006831	phosphorylation site [posttranslational modification]
323097006832	intermolecular recognition site; other site
323097006833	dimerization interface [polypeptide binding]; other site
323097006834	Response regulator receiver domain; Region: Response_reg; pfam00072
323097006835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097006836	active site
323097006837	phosphorylation site [posttranslational modification]
323097006838	intermolecular recognition site; other site
323097006839	dimerization interface [polypeptide binding]; other site
323097006840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097006841	Histidine kinase; Region: HisKA_2; pfam07568
323097006842	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097006843	ATP binding site [chemical binding]; other site
323097006844	Mg2+ binding site [ion binding]; other site
323097006845	G-X-G motif; other site
323097006846	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
323097006847	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
323097006848	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
323097006849	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
323097006850	Walker A/P-loop; other site
323097006851	ATP binding site [chemical binding]; other site
323097006852	Q-loop/lid; other site
323097006853	ABC transporter signature motif; other site
323097006854	Walker B; other site
323097006855	D-loop; other site
323097006856	H-loop/switch region; other site
323097006857	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
323097006858	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323097006859	FtsX-like permease family; Region: FtsX; pfam02687
323097006860	prolyl-tRNA synthetase; Provisional; Region: PRK12325
323097006861	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
323097006862	dimer interface [polypeptide binding]; other site
323097006863	motif 1; other site
323097006864	active site
323097006865	motif 2; other site
323097006866	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323097006867	active site
323097006868	motif 3; other site
323097006869	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
323097006870	anticodon binding site; other site
323097006871	CopC domain; Region: CopC; pfam04234
323097006872	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
323097006873	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
323097006874	Protein of unknown function (DUF461); Region: DUF461; pfam04314
323097006875	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
323097006876	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097006877	N-terminal plug; other site
323097006878	ligand-binding site [chemical binding]; other site
323097006879	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
323097006880	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
323097006881	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097006882	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
323097006883	dimer interface [polypeptide binding]; other site
323097006884	substrate binding site [chemical binding]; other site
323097006885	metal binding site [ion binding]; metal-binding site
323097006886	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
323097006887	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
323097006888	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
323097006889	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
323097006890	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
323097006891	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
323097006892	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
323097006893	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323097006894	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
323097006895	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323097006896	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
323097006897	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
323097006898	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323097006899	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
323097006900	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
323097006901	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
323097006902	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
323097006903	4Fe-4S binding domain; Region: Fer4; pfam00037
323097006904	4Fe-4S binding domain; Region: Fer4; pfam00037
323097006905	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
323097006906	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
323097006907	NADH dehydrogenase subunit G; Validated; Region: PRK09130
323097006908	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323097006909	catalytic loop [active]
323097006910	iron binding site [ion binding]; other site
323097006911	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
323097006912	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
323097006913	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
323097006914	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
323097006915	SLBB domain; Region: SLBB; pfam10531
323097006916	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
323097006917	NADH dehydrogenase subunit E; Validated; Region: PRK07539
323097006918	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
323097006919	putative dimer interface [polypeptide binding]; other site
323097006920	[2Fe-2S] cluster binding site [ion binding]; other site
323097006921	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
323097006922	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
323097006923	NADH dehydrogenase subunit D; Validated; Region: PRK06075
323097006924	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
323097006925	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
323097006926	NADH dehydrogenase subunit B; Validated; Region: PRK06411
323097006927	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
323097006928	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
323097006929	IHF - DNA interface [nucleotide binding]; other site
323097006930	IHF dimer interface [polypeptide binding]; other site
323097006931	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
323097006932	peptidase T; Region: peptidase-T; TIGR01882
323097006933	metal binding site [ion binding]; metal-binding site
323097006934	dimer interface [polypeptide binding]; other site
323097006935	Methyltransferase domain; Region: Methyltransf_31; pfam13847
323097006936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097006937	S-adenosylmethionine binding site [chemical binding]; other site
323097006938	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
323097006939	Found in ATP-dependent protease La (LON); Region: LON; smart00464
323097006940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097006941	Walker A motif; other site
323097006942	ATP binding site [chemical binding]; other site
323097006943	Walker B motif; other site
323097006944	arginine finger; other site
323097006945	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
323097006946	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
323097006947	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
323097006948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097006949	Walker A motif; other site
323097006950	ATP binding site [chemical binding]; other site
323097006951	Walker B motif; other site
323097006952	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
323097006953	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
323097006954	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
323097006955	oligomer interface [polypeptide binding]; other site
323097006956	active site residues [active]
323097006957	trigger factor; Provisional; Region: tig; PRK01490
323097006958	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
323097006959	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
323097006960	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
323097006961	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
323097006962	Multicopper oxidase; Region: Cu-oxidase; pfam00394
323097006963	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
323097006964	Uncharacterized conserved protein [Function unknown]; Region: COG0062
323097006965	putative carbohydrate kinase; Provisional; Region: PRK10565
323097006966	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
323097006967	putative substrate binding site [chemical binding]; other site
323097006968	putative ATP binding site [chemical binding]; other site
323097006969	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
323097006970	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323097006971	glutamine synthetase; Provisional; Region: glnA; PRK09469
323097006972	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
323097006973	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
323097006974	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
323097006975	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
323097006976	Transcriptional regulators [Transcription]; Region: MarR; COG1846
323097006977	MarR family; Region: MarR_2; cl17246
323097006978	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
323097006979	dimer interface [polypeptide binding]; other site
323097006980	allosteric magnesium binding site [ion binding]; other site
323097006981	active site
323097006982	aspartate-rich active site metal binding site; other site
323097006983	Schiff base residues; other site
323097006984	RDD family; Region: RDD; pfam06271
323097006985	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
323097006986	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
323097006987	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
323097006988	manganese transport protein MntH; Reviewed; Region: PRK00701
323097006989	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
323097006990	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
323097006991	ArsC family; Region: ArsC; pfam03960
323097006992	catalytic residues [active]
323097006993	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
323097006994	amphipathic channel; other site
323097006995	Asn-Pro-Ala signature motifs; other site
323097006996	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097006997	putative DNA binding site [nucleotide binding]; other site
323097006998	putative Zn2+ binding site [ion binding]; other site
323097006999	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
323097007000	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
323097007001	CAP-like domain; other site
323097007002	active site
323097007003	primary dimer interface [polypeptide binding]; other site
323097007004	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
323097007005	Recombination protein O N terminal; Region: RecO_N; pfam11967
323097007006	Recombination protein O C terminal; Region: RecO_C; pfam02565
323097007007	GTPase Era; Reviewed; Region: era; PRK00089
323097007008	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
323097007009	G1 box; other site
323097007010	GTP/Mg2+ binding site [chemical binding]; other site
323097007011	Switch I region; other site
323097007012	G2 box; other site
323097007013	Switch II region; other site
323097007014	G3 box; other site
323097007015	G4 box; other site
323097007016	G5 box; other site
323097007017	KH domain; Region: KH_2; pfam07650
323097007018	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
323097007019	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
323097007020	dimerization interface [polypeptide binding]; other site
323097007021	active site
323097007022	metal binding site [ion binding]; metal-binding site
323097007023	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
323097007024	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
323097007025	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
323097007026	Catalytic site [active]
323097007027	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
323097007028	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
323097007029	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
323097007030	active site
323097007031	hydrophilic channel; other site
323097007032	dimerization interface [polypeptide binding]; other site
323097007033	catalytic residues [active]
323097007034	active site lid [active]
323097007035	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
323097007036	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
323097007037	Zn2+ binding site [ion binding]; other site
323097007038	Mg2+ binding site [ion binding]; other site
323097007039	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
323097007040	synthetase active site [active]
323097007041	NTP binding site [chemical binding]; other site
323097007042	metal binding site [ion binding]; metal-binding site
323097007043	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
323097007044	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
323097007045	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
323097007046	LabA_like proteins; Region: LabA; cd10911
323097007047	Uncharacterized conserved protein [Function unknown]; Region: COG1432
323097007048	putative metal binding site [ion binding]; other site
323097007049	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
323097007050	Fe-S cluster binding site [ion binding]; other site
323097007051	DNA binding site [nucleotide binding]
323097007052	active site
323097007053	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
323097007054	SmpB-tmRNA interface; other site
323097007055	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
323097007056	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
323097007057	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
323097007058	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
323097007059	dimer interface [polypeptide binding]; other site
323097007060	active site
323097007061	catalytic residue [active]
323097007062	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
323097007063	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323097007064	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323097007065	catalytic residue [active]
323097007066	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
323097007067	Porin subfamily; Region: Porin_2; pfam02530
323097007068	Porin subfamily; Region: Porin_2; pfam02530
323097007069	Suppression of tumorigenicity 7; Region: ST7; cd11557
323097007070	orc1/cdc6 family replication initiation protein; Region: TIGR02928
323097007071	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
323097007072	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
323097007073	GatB domain; Region: GatB_Yqey; smart00845
323097007074	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097007075	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097007076	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097007077	Patatin-like phospholipase; Region: Patatin; pfam01734
323097007078	active site
323097007079	nucleophile elbow; other site
323097007080	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
323097007081	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
323097007082	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
323097007083	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
323097007084	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
323097007085	FMN binding site [chemical binding]; other site
323097007086	substrate binding site [chemical binding]; other site
323097007087	putative catalytic residue [active]
323097007088	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
323097007089	CAAX protease self-immunity; Region: Abi; pfam02517
323097007090	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323097007091	active site
323097007092	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
323097007093	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
323097007094	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
323097007095	dihydroorotase; Validated; Region: PRK09059
323097007096	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
323097007097	active site
323097007098	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
323097007099	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
323097007100	DNA protecting protein DprA; Region: dprA; TIGR00732
323097007101	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322
323097007102	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
323097007103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097007104	S-adenosylmethionine binding site [chemical binding]; other site
323097007105	replicative DNA helicase; Provisional; Region: PRK09165
323097007106	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
323097007107	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
323097007108	Walker A motif; other site
323097007109	ATP binding site [chemical binding]; other site
323097007110	Walker B motif; other site
323097007111	DNA binding loops [nucleotide binding]
323097007112	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
323097007113	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
323097007114	active site
323097007115	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323097007116	dimer interface [polypeptide binding]; other site
323097007117	substrate binding site [chemical binding]; other site
323097007118	catalytic residues [active]
323097007119	DNA repair protein RadA; Provisional; Region: PRK11823
323097007120	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323097007121	Walker A motif; other site
323097007122	ATP binding site [chemical binding]; other site
323097007123	Walker B motif; other site
323097007124	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
323097007125	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
323097007126	Colicin V production protein; Region: Colicin_V; pfam02674
323097007127	amidophosphoribosyltransferase; Provisional; Region: PRK09123
323097007128	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
323097007129	active site
323097007130	tetramer interface [polypeptide binding]; other site
323097007131	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323097007132	active site
323097007133	Protease prsW family; Region: PrsW-protease; pfam13367
323097007134	acid-resistance membrane protein; Provisional; Region: PRK10209
323097007135	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
323097007136	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097007137	FeS/SAM binding site; other site
323097007138	Radical SAM superfamily; Region: Radical_SAM; pfam04055
323097007139	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
323097007140	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323097007141	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
323097007142	motif 1; other site
323097007143	dimer interface [polypeptide binding]; other site
323097007144	active site
323097007145	motif 2; other site
323097007146	motif 3; other site
323097007147	elongation factor P; Validated; Region: PRK00529
323097007148	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
323097007149	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
323097007150	RNA binding site [nucleotide binding]; other site
323097007151	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
323097007152	RNA binding site [nucleotide binding]; other site
323097007153	Peptidase family M23; Region: Peptidase_M23; pfam01551
323097007154	lytic murein transglycosylase; Region: MltB_2; TIGR02283
323097007155	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323097007156	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323097007157	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323097007158	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
323097007159	homotrimer interaction site [polypeptide binding]; other site
323097007160	putative active site [active]
323097007161	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097007162	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097007163	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097007164	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
323097007165	DHH family; Region: DHH; pfam01368
323097007166	DHHA1 domain; Region: DHHA1; pfam02272
323097007167	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
323097007168	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
323097007169	putative active site [active]
323097007170	homoserine dehydrogenase; Provisional; Region: PRK06349
323097007171	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
323097007172	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
323097007173	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
323097007174	aminotransferase; Validated; Region: PRK09148
323097007175	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323097007176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097007177	homodimer interface [polypeptide binding]; other site
323097007178	catalytic residue [active]
323097007179	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
323097007180	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
323097007181	MAPEG family; Region: MAPEG; pfam01124
323097007182	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
323097007183	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
323097007184	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
323097007185	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
323097007186	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
323097007187	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097007188	Mg2+ binding site [ion binding]; other site
323097007189	G-X-G motif; other site
323097007190	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
323097007191	anchoring element; other site
323097007192	dimer interface [polypeptide binding]; other site
323097007193	ATP binding site [chemical binding]; other site
323097007194	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
323097007195	active site
323097007196	putative metal-binding site [ion binding]; other site
323097007197	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
323097007198	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
323097007199	hypothetical protein; Provisional; Region: PRK06185
323097007200	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323097007201	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
323097007202	DEAD-like helicases superfamily; Region: DEXDc; smart00487
323097007203	ATP binding site [chemical binding]; other site
323097007204	Mg++ binding site [ion binding]; other site
323097007205	motif III; other site
323097007206	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097007207	nucleotide binding region [chemical binding]; other site
323097007208	ATP-binding site [chemical binding]; other site
323097007209	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323097007210	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323097007211	metal binding site [ion binding]; metal-binding site
323097007212	active site
323097007213	I-site; other site
323097007214	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
323097007215	Domain of unknown function DUF59; Region: DUF59; cl00941
323097007216	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
323097007217	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
323097007218	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323097007219	catalytic residue [active]
323097007220	FeS assembly protein SufD; Region: sufD; TIGR01981
323097007221	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
323097007222	FeS assembly ATPase SufC; Region: sufC; TIGR01978
323097007223	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
323097007224	Walker A/P-loop; other site
323097007225	ATP binding site [chemical binding]; other site
323097007226	Q-loop/lid; other site
323097007227	ABC transporter signature motif; other site
323097007228	Walker B; other site
323097007229	D-loop; other site
323097007230	H-loop/switch region; other site
323097007231	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
323097007232	putative ABC transporter; Region: ycf24; CHL00085
323097007233	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
323097007234	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
323097007235	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323097007236	catalytic residue [active]
323097007237	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
323097007238	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
323097007239	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
323097007240	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
323097007241	active site
323097007242	HIGH motif; other site
323097007243	dimer interface [polypeptide binding]; other site
323097007244	KMSKS motif; other site
323097007245	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323097007246	RNA binding surface [nucleotide binding]; other site
323097007247	Protein of unknown function; Region: DUF3971; pfam13116
323097007248	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
323097007249	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
323097007250	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
323097007251	catalytic triad [active]
323097007252	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
323097007253	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
323097007254	Peptidase family M23; Region: Peptidase_M23; pfam01551
323097007255	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
323097007256	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097007257	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097007258	ABC transporter; Region: ABC_tran_2; pfam12848
323097007259	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097007260	DNA polymerase III subunit chi; Validated; Region: PRK05728
323097007261	multifunctional aminopeptidase A; Provisional; Region: PRK00913
323097007262	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
323097007263	interface (dimer of trimers) [polypeptide binding]; other site
323097007264	Substrate-binding/catalytic site; other site
323097007265	Zn-binding sites [ion binding]; other site
323097007266	Predicted permeases [General function prediction only]; Region: COG0795
323097007267	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
323097007268	Predicted permeases [General function prediction only]; Region: COG0795
323097007269	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
323097007270	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
323097007271	OstA-like protein; Region: OstA; cl00844
323097007272	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323097007273	Organic solvent tolerance protein; Region: OstA_C; pfam04453
323097007274	SurA N-terminal domain; Region: SurA_N; pfam09312
323097007275	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
323097007276	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
323097007277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097007278	S-adenosylmethionine binding site [chemical binding]; other site
323097007279	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
323097007280	6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240
323097007281	putative NAD(P) binding site [chemical binding]; other site
323097007282	catalytic Zn binding site [ion binding]; other site
323097007283	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
323097007284	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
323097007285	catalytic site [active]
323097007286	G-X2-G-X-G-K; other site
323097007287	hypothetical protein; Provisional; Region: PRK11820
323097007288	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
323097007289	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
323097007290	YceG-like family; Region: YceG; pfam02618
323097007291	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
323097007292	dimerization interface [polypeptide binding]; other site
323097007293	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
323097007294	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
323097007295	dimer interface [polypeptide binding]; other site
323097007296	active site
323097007297	acyl carrier protein; Provisional; Region: acpP; PRK00982
323097007298	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
323097007299	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097007300	NAD(P) binding site [chemical binding]; other site
323097007301	active site
323097007302	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
323097007303	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
323097007304	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
323097007305	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
323097007306	PRC-barrel domain; Region: PRC; pfam05239
323097007307	HNH endonuclease; Region: HNH_3; pfam13392
323097007308	DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033
323097007309	DNA binding site [nucleotide binding]
323097007310	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
323097007311	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097007312	S-adenosylmethionine binding site [chemical binding]; other site
323097007313	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
323097007314	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097007315	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097007316	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
323097007317	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
323097007318	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
323097007319	Phage Tail Protein X; Region: Phage_tail_X; cl02088
323097007320	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
323097007321	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
323097007322	Phage tail tube protein FII; Region: Phage_tube; pfam04985
323097007323	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
323097007324	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
323097007325	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
323097007326	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
323097007327	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
323097007328	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
323097007329	Baseplate J-like protein; Region: Baseplate_J; cl01294
323097007330	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
323097007331	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
323097007332	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
323097007333	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
323097007334	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
323097007335	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
323097007336	oligomer interface [polypeptide binding]; other site
323097007337	active site residues [active]
323097007338	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
323097007339	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
323097007340	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
323097007341	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
323097007342	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
323097007343	Transcription antiterminator [Transcription]; Region: NusG; COG0250
323097007344	Transcription termination factor nusG; Region: NusG; pfam02357
323097007345	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
323097007346	heterodimer interface [polypeptide binding]; other site
323097007347	homodimer interface [polypeptide binding]; other site
323097007348	TSCPD domain; Region: TSCPD; cl14834
323097007349	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
323097007350	non-specific DNA binding site [nucleotide binding]; other site
323097007351	salt bridge; other site
323097007352	Predicted transcriptional regulator [Transcription]; Region: COG2932
323097007353	sequence-specific DNA binding site [nucleotide binding]; other site
323097007354	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
323097007355	Catalytic site [active]
323097007356	NADH dehydrogenase subunit G; Validated; Region: PRK08166
323097007357	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
323097007358	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
323097007359	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
323097007360	active site
323097007361	catalytic residues [active]
323097007362	DNA binding site [nucleotide binding]
323097007363	Int/Topo IB signature motif; other site
323097007364	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
323097007365	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
323097007366	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
323097007367	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
323097007368	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097007369	Walker A motif; other site
323097007370	ATP binding site [chemical binding]; other site
323097007371	Walker B motif; other site
323097007372	arginine finger; other site
323097007373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097007374	Walker A motif; other site
323097007375	ATP binding site [chemical binding]; other site
323097007376	Walker B motif; other site
323097007377	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
323097007378	Uncharacterized conserved protein [Function unknown]; Region: COG2127
323097007379	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
323097007380	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
323097007381	Phasin protein; Region: Phasin_2; pfam09361
323097007382	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
323097007383	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
323097007384	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
323097007385	HSP70 interaction site [polypeptide binding]; other site
323097007386	von Willebrand factor type A domain; Region: VWA_2; pfam13519
323097007387	pantoate--beta-alanine ligase; Region: panC; TIGR00018
323097007388	Pantoate-beta-alanine ligase; Region: PanC; cd00560
323097007389	active site
323097007390	ATP-binding site [chemical binding]; other site
323097007391	pantoate-binding site; other site
323097007392	HXXH motif; other site
323097007393	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
323097007394	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
323097007395	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
323097007396	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323097007397	putative C-terminal domain interface [polypeptide binding]; other site
323097007398	putative GSH binding site (G-site) [chemical binding]; other site
323097007399	putative dimer interface [polypeptide binding]; other site
323097007400	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
323097007401	putative N-terminal domain interface [polypeptide binding]; other site
323097007402	putative dimer interface [polypeptide binding]; other site
323097007403	putative substrate binding pocket (H-site) [chemical binding]; other site
323097007404	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
323097007405	Uncharacterized conserved protein [Function unknown]; Region: COG1434
323097007406	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
323097007407	putative active site [active]
323097007408	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
323097007409	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
323097007410	active site
323097007411	catalytic tetrad [active]
323097007412	Predicted transcriptional regulator [Transcription]; Region: COG2944
323097007413	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097007414	non-specific DNA binding site [nucleotide binding]; other site
323097007415	salt bridge; other site
323097007416	sequence-specific DNA binding site [nucleotide binding]; other site
323097007417	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
323097007418	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
323097007419	NodB motif; other site
323097007420	active site
323097007421	catalytic site [active]
323097007422	metal binding site [ion binding]; metal-binding site
323097007423	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
323097007424	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
323097007425	NodB motif; other site
323097007426	active site
323097007427	catalytic site [active]
323097007428	metal binding site [ion binding]; metal-binding site
323097007429	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
323097007430	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
323097007431	active site
323097007432	interdomain interaction site; other site
323097007433	putative metal-binding site [ion binding]; other site
323097007434	nucleotide binding site [chemical binding]; other site
323097007435	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
323097007436	domain I; other site
323097007437	DNA binding groove [nucleotide binding]
323097007438	phosphate binding site [ion binding]; other site
323097007439	domain II; other site
323097007440	domain III; other site
323097007441	nucleotide binding site [chemical binding]; other site
323097007442	catalytic site [active]
323097007443	domain IV; other site
323097007444	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
323097007445	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
323097007446	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
323097007447	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
323097007448	ribonuclease R; Region: RNase_R; TIGR02063
323097007449	RNB domain; Region: RNB; pfam00773
323097007450	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
323097007451	RNA binding site [nucleotide binding]; other site
323097007452	hypothetical protein; Provisional; Region: PRK05978
323097007453	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
323097007454	response regulator PleD; Reviewed; Region: pleD; PRK09581
323097007455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097007456	active site
323097007457	phosphorylation site [posttranslational modification]
323097007458	intermolecular recognition site; other site
323097007459	dimerization interface [polypeptide binding]; other site
323097007460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097007461	active site
323097007462	phosphorylation site [posttranslational modification]
323097007463	intermolecular recognition site; other site
323097007464	dimerization interface [polypeptide binding]; other site
323097007465	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323097007466	metal binding site [ion binding]; metal-binding site
323097007467	active site
323097007468	I-site; other site
323097007469	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323097007470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097007471	active site
323097007472	phosphorylation site [posttranslational modification]
323097007473	intermolecular recognition site; other site
323097007474	dimerization interface [polypeptide binding]; other site
323097007475	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
323097007476	DNA polymerase IV; Provisional; Region: PRK02794
323097007477	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
323097007478	active site
323097007479	DNA binding site [nucleotide binding]
323097007480	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
323097007481	Homeodomain-like domain; Region: HTH_23; pfam13384
323097007482	Winged helix-turn helix; Region: HTH_29; pfam13551
323097007483	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097007484	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097007485	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
323097007486	homotrimer interaction site [polypeptide binding]; other site
323097007487	putative active site [active]
323097007488	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
323097007489	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
323097007490	putative active site [active]
323097007491	catalytic site [active]
323097007492	putative metal binding site [ion binding]; other site
323097007493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
323097007494	Protein of unknown function, DUF482; Region: DUF482; pfam04339
323097007495	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
323097007496	HIT family signature motif; other site
323097007497	catalytic residue [active]
323097007498	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
323097007499	homodimer interaction site [polypeptide binding]; other site
323097007500	cofactor binding site; other site
323097007501	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323097007502	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323097007503	catalytic residue [active]
323097007504	Sporulation related domain; Region: SPOR; pfam05036
323097007505	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
323097007506	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
323097007507	23S rRNA interface [nucleotide binding]; other site
323097007508	L3 interface [polypeptide binding]; other site
323097007509	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
323097007510	CoenzymeA binding site [chemical binding]; other site
323097007511	subunit interaction site [polypeptide binding]; other site
323097007512	PHB binding site; other site
323097007513	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
323097007514	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
323097007515	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
323097007516	homodimer interface [polypeptide binding]; other site
323097007517	substrate-cofactor binding pocket; other site
323097007518	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097007519	catalytic residue [active]
323097007520	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
323097007521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097007522	putative substrate translocation pore; other site
323097007523	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
323097007524	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
323097007525	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
323097007526	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
323097007527	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
323097007528	Chain length determinant protein; Region: Wzz; pfam02706
323097007529	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
323097007530	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
323097007531	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
323097007532	SLBB domain; Region: SLBB; pfam10531
323097007533	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
323097007534	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097007535	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
323097007536	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
323097007537	Uncharacterized conserved protein [Function unknown]; Region: COG3268
323097007538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097007539	Phage capsid family; Region: Phage_capsid; pfam05065
323097007540	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
323097007541	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097007542	active site
323097007543	Int/Topo IB signature motif; other site
323097007544	DNA binding site [nucleotide binding]
323097007545	acetolactate synthase; Reviewed; Region: PRK08617
323097007546	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
323097007547	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
323097007548	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
323097007549	Phage terminase, small subunit; Region: Terminase_4; pfam05119
323097007550	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
323097007551	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
323097007552	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
323097007553	oligomerization interface [polypeptide binding]; other site
323097007554	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
323097007555	Phage capsid family; Region: Phage_capsid; pfam05065
323097007556	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
323097007557	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
323097007558	Phage-related protein [Function unknown]; Region: COG4695; cl01923
323097007559	Phage portal protein; Region: Phage_portal; pfam04860
323097007560	Transposase domain (DUF772); Region: DUF772; pfam05598
323097007561	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097007562	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097007563	PRC-barrel domain; Region: PRC; pfam05239
323097007564	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
323097007565	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
323097007566	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
323097007567	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
323097007568	Homeodomain-like domain; Region: HTH_23; pfam13384
323097007569	Winged helix-turn helix; Region: HTH_29; pfam13551
323097007570	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097007571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097007572	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
323097007573	additional DNA contacts [nucleotide binding]; other site
323097007574	mismatch recognition site; other site
323097007575	active site
323097007576	zinc binding site [ion binding]; other site
323097007577	DNA intercalation site [nucleotide binding]; other site
323097007578	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
323097007579	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323097007580	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097007581	non-specific DNA binding site [nucleotide binding]; other site
323097007582	salt bridge; other site
323097007583	sequence-specific DNA binding site [nucleotide binding]; other site
323097007584	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
323097007585	polymerase nucleotide-binding site; other site
323097007586	DNA-binding residues [nucleotide binding]; DNA binding site
323097007587	nucleotide binding site [chemical binding]; other site
323097007588	primase nucleotide-binding site [nucleotide binding]; other site
323097007589	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
323097007590	Virulence-associated protein E; Region: VirE; pfam05272
323097007591	Helix-turn-helix domain; Region: HTH_17; cl17695
323097007592	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097007593	active site
323097007594	DNA binding site [nucleotide binding]
323097007595	Int/Topo IB signature motif; other site
323097007596	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
323097007597	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323097007598	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
323097007599	Putative glucoamylase; Region: Glycoamylase; pfam10091
323097007600	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
323097007601	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
323097007602	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
323097007603	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097007604	DNA-binding site [nucleotide binding]; DNA binding site
323097007605	RNA-binding motif; other site
323097007606	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323097007607	PAS domain; Region: PAS_9; pfam13426
323097007608	putative active site [active]
323097007609	heme pocket [chemical binding]; other site
323097007610	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097007611	Histidine kinase; Region: HisKA_2; pfam07568
323097007612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097007613	ATP binding site [chemical binding]; other site
323097007614	Mg2+ binding site [ion binding]; other site
323097007615	G-X-G motif; other site
323097007616	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323097007617	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323097007618	ligand binding site [chemical binding]; other site
323097007619	flexible hinge region; other site
323097007620	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
323097007621	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
323097007622	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
323097007623	tetramer interface [polypeptide binding]; other site
323097007624	catalytic Zn binding site [ion binding]; other site
323097007625	NADP binding site [chemical binding]; other site
323097007626	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323097007627	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
323097007628	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
323097007629	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097007630	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
323097007631	Walker A/P-loop; other site
323097007632	ATP binding site [chemical binding]; other site
323097007633	Q-loop/lid; other site
323097007634	ABC transporter signature motif; other site
323097007635	Walker B; other site
323097007636	D-loop; other site
323097007637	H-loop/switch region; other site
323097007638	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
323097007639	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_6; cd04619
323097007640	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
323097007641	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
323097007642	putative di-iron ligands [ion binding]; other site
323097007643	GMP synthase; Reviewed; Region: guaA; PRK00074
323097007644	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
323097007645	AMP/PPi binding site [chemical binding]; other site
323097007646	candidate oxyanion hole; other site
323097007647	catalytic triad [active]
323097007648	potential glutamine specificity residues [chemical binding]; other site
323097007649	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
323097007650	ATP Binding subdomain [chemical binding]; other site
323097007651	Ligand Binding sites [chemical binding]; other site
323097007652	Dimerization subdomain; other site
323097007653	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
323097007654	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
323097007655	MAPEG family; Region: MAPEG; cl09190
323097007656	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
323097007657	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
323097007658	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
323097007659	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
323097007660	active site
323097007661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097007662	putative transporter; Provisional; Region: PRK10504
323097007663	putative substrate translocation pore; other site
323097007664	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
323097007665	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
323097007666	exopolyphosphatase; Region: exo_poly_only; TIGR03706
323097007667	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
323097007668	hypothetical protein; Validated; Region: PRK00124
323097007669	ABC transporter ATPase component; Reviewed; Region: PRK11147
323097007670	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097007671	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097007672	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097007673	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
323097007674	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
323097007675	putative active site [active]
323097007676	putative catalytic site [active]
323097007677	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
323097007678	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
323097007679	active site
323097007680	acyl-activating enzyme (AAE) consensus motif; other site
323097007681	putative CoA binding site [chemical binding]; other site
323097007682	AMP binding site [chemical binding]; other site
323097007683	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
323097007684	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
323097007685	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
323097007686	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
323097007687	substrate binding site [chemical binding]; other site
323097007688	oxyanion hole (OAH) forming residues; other site
323097007689	trimer interface [polypeptide binding]; other site
323097007690	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
323097007691	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323097007692	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
323097007693	substrate binding pocket [chemical binding]; other site
323097007694	FAD binding site [chemical binding]; other site
323097007695	catalytic base [active]
323097007696	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
323097007697	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
323097007698	tetrameric interface [polypeptide binding]; other site
323097007699	NAD binding site [chemical binding]; other site
323097007700	catalytic residues [active]
323097007701	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
323097007702	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
323097007703	active site
323097007704	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
323097007705	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
323097007706	Uncharacterized conserved protein [Function unknown]; Region: COG3791
323097007707	Tim44-like domain; Region: Tim44; pfam04280
323097007708	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
323097007709	adenylosuccinate lyase; Provisional; Region: PRK07492
323097007710	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
323097007711	tetramer interface [polypeptide binding]; other site
323097007712	active site
323097007713	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
323097007714	PilZ domain; Region: PilZ; pfam07238
323097007715	PilZ domain; Region: PilZ; pfam07238
323097007716	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
323097007717	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
323097007718	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
323097007719	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
323097007720	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
323097007721	trimer interface [polypeptide binding]; other site
323097007722	putative metal binding site [ion binding]; other site
323097007723	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
323097007724	serine acetyltransferase; Provisional; Region: cysE; PRK11132
323097007725	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
323097007726	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
323097007727	trimer interface [polypeptide binding]; other site
323097007728	active site
323097007729	substrate binding site [chemical binding]; other site
323097007730	CoA binding site [chemical binding]; other site
323097007731	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
323097007732	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
323097007733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
323097007734	salicylate hydroxylase; Provisional; Region: PRK08163
323097007735	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323097007736	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
323097007737	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
323097007738	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
323097007739	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
323097007740	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
323097007741	putative catalytic residue [active]
323097007742	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323097007743	active site
323097007744	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
323097007745	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
323097007746	putative MPT binding site; other site
323097007747	Usg-like family; Region: Usg; pfam06233
323097007748	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
323097007749	oligomerisation interface [polypeptide binding]; other site
323097007750	mobile loop; other site
323097007751	roof hairpin; other site
323097007752	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
323097007753	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
323097007754	ring oligomerisation interface [polypeptide binding]; other site
323097007755	ATP/Mg binding site [chemical binding]; other site
323097007756	stacking interactions; other site
323097007757	hinge regions; other site
323097007758	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
323097007759	putative dimer interface [polypeptide binding]; other site
323097007760	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097007761	Transposase domain (DUF772); Region: DUF772; pfam05598
323097007762	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097007763	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097007764	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
323097007765	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
323097007766	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
323097007767	Ligand binding site; other site
323097007768	Putative Catalytic site; other site
323097007769	DXD motif; other site
323097007770	Predicted membrane protein [Function unknown]; Region: COG2246
323097007771	GtrA-like protein; Region: GtrA; pfam04138
323097007772	Protein of unknown function DUF72; Region: DUF72; pfam01904
323097007773	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
323097007774	putative MPT binding site; other site
323097007775	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
323097007776	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
323097007777	Ligand binding site; other site
323097007778	metal-binding site
323097007779	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
323097007780	XdhC Rossmann domain; Region: XdhC_C; pfam13478
323097007781	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
323097007782	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
323097007783	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
323097007784	metal ion-dependent adhesion site (MIDAS); other site
323097007785	MoxR-like ATPases [General function prediction only]; Region: COG0714
323097007786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097007787	Walker A motif; other site
323097007788	ATP binding site [chemical binding]; other site
323097007789	Walker B motif; other site
323097007790	arginine finger; other site
323097007791	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
323097007792	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
323097007793	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
323097007794	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323097007795	catalytic loop [active]
323097007796	iron binding site [ion binding]; other site
323097007797	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
323097007798	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
323097007799	putative hydrophobic ligand binding site [chemical binding]; other site
323097007800	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
323097007801	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
323097007802	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
323097007803	TM-ABC transporter signature motif; other site
323097007804	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
323097007805	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
323097007806	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
323097007807	TM-ABC transporter signature motif; other site
323097007808	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
323097007809	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
323097007810	Walker A/P-loop; other site
323097007811	ATP binding site [chemical binding]; other site
323097007812	Q-loop/lid; other site
323097007813	ABC transporter signature motif; other site
323097007814	Walker B; other site
323097007815	D-loop; other site
323097007816	H-loop/switch region; other site
323097007817	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
323097007818	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
323097007819	Walker A/P-loop; other site
323097007820	ATP binding site [chemical binding]; other site
323097007821	Q-loop/lid; other site
323097007822	ABC transporter signature motif; other site
323097007823	Walker B; other site
323097007824	D-loop; other site
323097007825	H-loop/switch region; other site
323097007826	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
323097007827	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
323097007828	dimerization interface [polypeptide binding]; other site
323097007829	ligand binding site [chemical binding]; other site
323097007830	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
323097007831	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
323097007832	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
323097007833	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
323097007834	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
323097007835	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
323097007836	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
323097007837	substrate binding site [chemical binding]; other site
323097007838	hexamer interface [polypeptide binding]; other site
323097007839	metal binding site [ion binding]; metal-binding site
323097007840	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
323097007841	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097007842	N-terminal plug; other site
323097007843	ligand-binding site [chemical binding]; other site
323097007844	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323097007845	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323097007846	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097007847	putative active site [active]
323097007848	heme pocket [chemical binding]; other site
323097007849	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097007850	dimer interface [polypeptide binding]; other site
323097007851	phosphorylation site [posttranslational modification]
323097007852	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097007853	ATP binding site [chemical binding]; other site
323097007854	Mg2+ binding site [ion binding]; other site
323097007855	G-X-G motif; other site
323097007856	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
323097007857	Predicted transcriptional regulator [Transcription]; Region: COG4957
323097007858	hypothetical protein; Validated; Region: PRK09104
323097007859	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
323097007860	metal binding site [ion binding]; metal-binding site
323097007861	putative dimer interface [polypeptide binding]; other site
323097007862	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
323097007863	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
323097007864	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
323097007865	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
323097007866	dihydropteroate synthase; Region: DHPS; TIGR01496
323097007867	substrate binding pocket [chemical binding]; other site
323097007868	dimer interface [polypeptide binding]; other site
323097007869	inhibitor binding site; inhibition site
323097007870	Dihydroneopterin aldolase; Region: FolB; pfam02152
323097007871	active site
323097007872	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
323097007873	catalytic center binding site [active]
323097007874	ATP binding site [chemical binding]; other site
323097007875	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
323097007876	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
323097007877	heterodimer interface [polypeptide binding]; other site
323097007878	substrate interaction site [chemical binding]; other site
323097007879	Uncharacterized conserved protein [Function unknown]; Region: COG3791
323097007880	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
323097007881	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
323097007882	active site
323097007883	substrate binding site [chemical binding]; other site
323097007884	coenzyme B12 binding site [chemical binding]; other site
323097007885	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
323097007886	B12 binding site [chemical binding]; other site
323097007887	cobalt ligand [ion binding]; other site
323097007888	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
323097007889	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
323097007890	membrane ATPase/protein kinase; Provisional; Region: PRK09435
323097007891	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
323097007892	Walker A; other site
323097007893	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
323097007894	G4 box; other site
323097007895	G5 box; other site
323097007896	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
323097007897	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097007898	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
323097007899	putative substrate binding pocket [chemical binding]; other site
323097007900	AC domain interface; other site
323097007901	catalytic triad [active]
323097007902	AB domain interface; other site
323097007903	interchain disulfide; other site
323097007904	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
323097007905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097007906	putative substrate translocation pore; other site
323097007907	twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808
323097007908	putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807
323097007909	High-affinity nickel-transport protein; Region: NicO; cl00964
323097007910	High-affinity nickel-transport protein; Region: NicO; cl00964
323097007911	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
323097007912	putative metal binding site [ion binding]; other site
323097007913	putative homodimer interface [polypeptide binding]; other site
323097007914	putative homotetramer interface [polypeptide binding]; other site
323097007915	putative homodimer-homodimer interface [polypeptide binding]; other site
323097007916	putative allosteric switch controlling residues; other site
323097007917	TIGR03809 family protein; Region: TIGR03809
323097007918	Predicted membrane protein [Function unknown]; Region: COG2261
323097007919	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
323097007920	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
323097007921	active site
323097007922	catalytic triad [active]
323097007923	RNA polymerase sigma factor; Provisional; Region: PRK12515
323097007924	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323097007925	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323097007926	DNA binding residues [nucleotide binding]
323097007927	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
323097007928	enoyl-CoA hydratase; Provisional; Region: PRK05862
323097007929	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
323097007930	substrate binding site [chemical binding]; other site
323097007931	oxyanion hole (OAH) forming residues; other site
323097007932	trimer interface [polypeptide binding]; other site
323097007933	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
323097007934	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
323097007935	threonine dehydratase; Provisional; Region: PRK07334
323097007936	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
323097007937	tetramer interface [polypeptide binding]; other site
323097007938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097007939	catalytic residue [active]
323097007940	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
323097007941	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
323097007942	putative active site [active]
323097007943	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
323097007944	putative PHP Thumb interface [polypeptide binding]; other site
323097007945	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
323097007946	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
323097007947	generic binding surface I; other site
323097007948	generic binding surface II; other site
323097007949	DNA Polymerase Y-family; Region: PolY_like; cd03468
323097007950	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
323097007951	DNA binding site [nucleotide binding]
323097007952	Uncharacterized conserved protein [Function unknown]; Region: COG4544
323097007953	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
323097007954	dimerization interface [polypeptide binding]; other site
323097007955	metal binding site [ion binding]; metal-binding site
323097007956	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
323097007957	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
323097007958	metal binding site [ion binding]; metal-binding site
323097007959	putative dimer interface [polypeptide binding]; other site
323097007960	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
323097007961	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323097007962	active site
323097007963	metal binding site [ion binding]; metal-binding site
323097007964	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
323097007965	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
323097007966	RNA polymerase sigma factor; Provisional; Region: PRK11924
323097007967	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323097007968	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323097007969	DNA binding residues [nucleotide binding]
323097007970	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
323097007971	Putative zinc-finger; Region: zf-HC2; pfam13490
323097007972	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
323097007973	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
323097007974	inhibitor-cofactor binding pocket; inhibition site
323097007975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097007976	catalytic residue [active]
323097007977	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
323097007978	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
323097007979	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
323097007980	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
323097007981	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
323097007982	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097007983	FeS/SAM binding site; other site
323097007984	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
323097007985	hypothetical protein; Provisional; Region: PRK07077
323097007986	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
323097007987	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
323097007988	Active site cavity [active]
323097007989	catalytic acid [active]
323097007990	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097007991	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
323097007992	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
323097007993	catalytic residues [active]
323097007994	substrate binding pocket [chemical binding]; other site
323097007995	substrate-Mg2+ binding site; other site
323097007996	aspartate-rich region 1; other site
323097007997	aspartate-rich region 2; other site
323097007998	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
323097007999	active site lid residues [active]
323097008000	substrate binding pocket [chemical binding]; other site
323097008001	catalytic residues [active]
323097008002	substrate-Mg2+ binding site; other site
323097008003	aspartate-rich region 1; other site
323097008004	aspartate-rich region 2; other site
323097008005	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
323097008006	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
323097008007	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
323097008008	B12 binding site [chemical binding]; other site
323097008009	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
323097008010	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
323097008011	amidase; Provisional; Region: PRK07056
323097008012	Amidase; Region: Amidase; cl11426
323097008013	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
323097008014	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
323097008015	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
323097008016	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
323097008017	Cytochrome P450; Region: p450; cl12078
323097008018	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
323097008019	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
323097008020	transcriptional regulator BetI; Validated; Region: PRK00767
323097008021	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323097008022	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
323097008023	Predicted transporter component [General function prediction only]; Region: COG2391
323097008024	Sulphur transport; Region: Sulf_transp; pfam04143
323097008025	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
323097008026	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097008027	hydroxyglutarate oxidase; Provisional; Region: PRK11728
323097008028	multidrug efflux protein; Reviewed; Region: PRK09579
323097008029	Protein export membrane protein; Region: SecD_SecF; cl14618
323097008030	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323097008031	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097008032	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097008033	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323097008034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323097008035	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
323097008036	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
323097008037	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
323097008038	NAD(P) binding site [chemical binding]; other site
323097008039	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
323097008040	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323097008041	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
323097008042	Beta-lactamase; Region: Beta-lactamase; pfam00144
323097008043	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
323097008044	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
323097008045	putative active site [active]
323097008046	putative catalytic site [active]
323097008047	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
323097008048	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
323097008049	Cu(I) binding site [ion binding]; other site
323097008050	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
323097008051	Putative water exit pathway; other site
323097008052	Binuclear center (active site) [active]
323097008053	K-pathway; other site
323097008054	Putative proton exit pathway; other site
323097008055	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
323097008056	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
323097008057	2-isopropylmalate synthase; Validated; Region: PRK00915
323097008058	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
323097008059	active site
323097008060	catalytic residues [active]
323097008061	metal binding site [ion binding]; metal-binding site
323097008062	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
323097008063	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
323097008064	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
323097008065	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097008066	Walker A/P-loop; other site
323097008067	ATP binding site [chemical binding]; other site
323097008068	Q-loop/lid; other site
323097008069	ABC transporter signature motif; other site
323097008070	Walker B; other site
323097008071	D-loop; other site
323097008072	H-loop/switch region; other site
323097008073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097008074	dimer interface [polypeptide binding]; other site
323097008075	conserved gate region; other site
323097008076	putative PBP binding loops; other site
323097008077	ABC-ATPase subunit interface; other site
323097008078	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
323097008079	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
323097008080	substrate binding pocket [chemical binding]; other site
323097008081	membrane-bound complex binding site; other site
323097008082	hinge residues; other site
323097008083	ketol-acid reductoisomerase; Provisional; Region: PRK05479
323097008084	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
323097008085	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
323097008086	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
323097008087	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
323097008088	putative valine binding site [chemical binding]; other site
323097008089	dimer interface [polypeptide binding]; other site
323097008090	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
323097008091	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
323097008092	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
323097008093	PYR/PP interface [polypeptide binding]; other site
323097008094	dimer interface [polypeptide binding]; other site
323097008095	TPP binding site [chemical binding]; other site
323097008096	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
323097008097	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
323097008098	TPP-binding site [chemical binding]; other site
323097008099	dimer interface [polypeptide binding]; other site
323097008100	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
323097008101	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
323097008102	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
323097008103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097008104	motif II; other site
323097008105	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
323097008106	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097008107	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097008108	protein binding site [polypeptide binding]; other site
323097008109	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097008110	protein binding site [polypeptide binding]; other site
323097008111	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
323097008112	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
323097008113	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
323097008114	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
323097008115	HflK protein; Region: hflK; TIGR01933
323097008116	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
323097008117	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
323097008118	folate binding site [chemical binding]; other site
323097008119	NADP+ binding site [chemical binding]; other site
323097008120	thymidylate synthase; Reviewed; Region: thyA; PRK01827
323097008121	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
323097008122	dimerization interface [polypeptide binding]; other site
323097008123	active site
323097008124	Stringent starvation protein B; Region: SspB; pfam04386
323097008125	fumarate hydratase; Reviewed; Region: fumC; PRK00485
323097008126	Class II fumarases; Region: Fumarase_classII; cd01362
323097008127	active site
323097008128	tetramer interface [polypeptide binding]; other site
323097008129	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
323097008130	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
323097008131	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
323097008132	AsmA family; Region: AsmA; pfam05170
323097008133	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
323097008134	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
323097008135	active site
323097008136	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
323097008137	Part of AAA domain; Region: AAA_19; pfam13245
323097008138	Family description; Region: UvrD_C_2; pfam13538
323097008139	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
323097008140	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
323097008141	Walker A/P-loop; other site
323097008142	ATP binding site [chemical binding]; other site
323097008143	Q-loop/lid; other site
323097008144	ABC transporter signature motif; other site
323097008145	Walker B; other site
323097008146	D-loop; other site
323097008147	H-loop/switch region; other site
323097008148	ABC-2 type transporter; Region: ABC2_membrane; cl17235
323097008149	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
323097008150	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097008151	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
323097008152	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
323097008153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097008154	S-adenosylmethionine binding site [chemical binding]; other site
323097008155	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
323097008156	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
323097008157	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
323097008158	active site
323097008159	Transposase domain (DUF772); Region: DUF772; pfam05598
323097008160	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097008161	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097008162	Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828
323097008163	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097008164	DNA-binding site [nucleotide binding]; DNA binding site
323097008165	RNA-binding motif; other site
323097008166	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
323097008167	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
323097008168	homotetramer interface [polypeptide binding]; other site
323097008169	ligand binding site [chemical binding]; other site
323097008170	catalytic site [active]
323097008171	NAD binding site [chemical binding]; other site
323097008172	S-adenosylmethionine synthetase; Validated; Region: PRK05250
323097008173	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
323097008174	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
323097008175	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
323097008176	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
323097008177	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
323097008178	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
323097008179	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
323097008180	Transposase domain (DUF772); Region: DUF772; pfam05598
323097008181	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097008182	Transposase domain (DUF772); Region: DUF772; pfam05598
323097008183	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
323097008184	Methyltransferase domain; Region: Methyltransf_24; pfam13578
323097008185	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323097008186	active site
323097008187	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
323097008188	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
323097008189	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097008190	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
323097008191	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097008192	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
323097008193	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
323097008194	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
323097008195	substrate binding site; other site
323097008196	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097008197	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
323097008198	NAD(P) binding site [chemical binding]; other site
323097008199	active site
323097008200	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
323097008201	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
323097008202	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323097008203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
323097008204	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
323097008205	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097008206	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
323097008207	NAD(P) binding site [chemical binding]; other site
323097008208	active site
323097008209	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
323097008210	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097008211	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
323097008212	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097008213	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097008214	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097008215	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097008216	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
323097008217	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097008218	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
323097008219	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097008220	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
323097008221	putative ADP-binding pocket [chemical binding]; other site
323097008222	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
323097008223	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
323097008224	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
323097008225	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
323097008226	Walker A/P-loop; other site
323097008227	ATP binding site [chemical binding]; other site
323097008228	Q-loop/lid; other site
323097008229	ABC transporter signature motif; other site
323097008230	Walker B; other site
323097008231	D-loop; other site
323097008232	H-loop/switch region; other site
323097008233	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
323097008234	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
323097008235	NADP-binding site; other site
323097008236	homotetramer interface [polypeptide binding]; other site
323097008237	substrate binding site [chemical binding]; other site
323097008238	homodimer interface [polypeptide binding]; other site
323097008239	active site
323097008240	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
323097008241	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097008242	NAD(P) binding site [chemical binding]; other site
323097008243	active site
323097008244	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
323097008245	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
323097008246	Substrate binding site; other site
323097008247	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
323097008248	Transposase, Mutator family; Region: Transposase_mut; pfam00872
323097008249	MULE transposase domain; Region: MULE; pfam10551
323097008250	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
323097008251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097008252	Walker A motif; other site
323097008253	ATP binding site [chemical binding]; other site
323097008254	Winged helix-turn helix; Region: HTH_29; pfam13551
323097008255	Helix-turn-helix domain; Region: HTH_28; pfam13518
323097008256	Homeodomain-like domain; Region: HTH_32; pfam13565
323097008257	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097008258	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323097008259	catalytic residues [active]
323097008260	catalytic nucleophile [active]
323097008261	Recombinase; Region: Recombinase; pfam07508
323097008262	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323097008263	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
323097008264	DNA-binding interface [nucleotide binding]; DNA binding site
323097008265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
323097008266	Integrase core domain; Region: rve; pfam00665
323097008267	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
323097008268	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
323097008269	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
323097008270	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
323097008271	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
323097008272	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
323097008273	Transposase, Mutator family; Region: Transposase_mut; pfam00872
323097008274	MULE transposase domain; Region: MULE; pfam10551
323097008275	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
323097008276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097008277	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
323097008278	NAD(P) binding site [chemical binding]; other site
323097008279	active site
323097008280	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097008281	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
323097008282	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
323097008283	NAD(P) binding site [chemical binding]; other site
323097008284	homodimer interface [polypeptide binding]; other site
323097008285	substrate binding site [chemical binding]; other site
323097008286	active site
323097008287	O-Antigen ligase; Region: Wzy_C; pfam04932
323097008288	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
323097008289	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
323097008290	Mg++ binding site [ion binding]; other site
323097008291	putative catalytic motif [active]
323097008292	putative substrate binding site [chemical binding]; other site
323097008293	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
323097008294	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
323097008295	homodimer interface [polypeptide binding]; other site
323097008296	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097008297	catalytic residue [active]
323097008298	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
323097008299	HIT family signature motif; other site
323097008300	catalytic residue [active]
323097008301	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
323097008302	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
323097008303	Walker A/P-loop; other site
323097008304	ATP binding site [chemical binding]; other site
323097008305	Q-loop/lid; other site
323097008306	ABC transporter signature motif; other site
323097008307	Walker B; other site
323097008308	D-loop; other site
323097008309	H-loop/switch region; other site
323097008310	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
323097008311	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
323097008312	TM-ABC transporter signature motif; other site
323097008313	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
323097008314	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
323097008315	Walker A/P-loop; other site
323097008316	ATP binding site [chemical binding]; other site
323097008317	Q-loop/lid; other site
323097008318	ABC transporter signature motif; other site
323097008319	Walker B; other site
323097008320	D-loop; other site
323097008321	H-loop/switch region; other site
323097008322	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
323097008323	TM-ABC transporter signature motif; other site
323097008324	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
323097008325	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
323097008326	putative ligand binding site [chemical binding]; other site
323097008327	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323097008328	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323097008329	ligand binding site [chemical binding]; other site
323097008330	flexible hinge region; other site
323097008331	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
323097008332	non-specific DNA interactions [nucleotide binding]; other site
323097008333	DNA binding site [nucleotide binding]
323097008334	sequence specific DNA binding site [nucleotide binding]; other site
323097008335	putative cAMP binding site [chemical binding]; other site
323097008336	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
323097008337	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
323097008338	inhibitor-cofactor binding pocket; inhibition site
323097008339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097008340	catalytic residue [active]
323097008341	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
323097008342	AAA domain; Region: AAA_26; pfam13500
323097008343	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
323097008344	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
323097008345	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323097008346	catalytic residue [active]
323097008347	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
323097008348	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
323097008349	quinolinate synthetase; Provisional; Region: PRK09375
323097008350	L-aspartate oxidase; Provisional; Region: PRK07512
323097008351	L-aspartate oxidase; Provisional; Region: PRK06175
323097008352	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
323097008353	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
323097008354	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
323097008355	dimerization interface [polypeptide binding]; other site
323097008356	active site
323097008357	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
323097008358	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
323097008359	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
323097008360	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
323097008361	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
323097008362	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097008363	AAA domain; Region: AAA_27; pfam13514
323097008364	Walker A/P-loop; other site
323097008365	ATP binding site [chemical binding]; other site
323097008366	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
323097008367	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323097008368	active site
323097008369	metal binding site [ion binding]; metal-binding site
323097008370	DNA binding site [nucleotide binding]
323097008371	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
323097008372	Fic/DOC family; Region: Fic; pfam02661
323097008373	Homeodomain-like domain; Region: HTH_23; pfam13384
323097008374	Winged helix-turn helix; Region: HTH_29; pfam13551
323097008375	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097008376	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097008377	Homeodomain-like domain; Region: HTH_23; pfam13384
323097008378	Winged helix-turn helix; Region: HTH_29; pfam13551
323097008379	Homeodomain-like domain; Region: HTH_32; pfam13565
323097008380	Uncharacterized conserved protein [Function unknown]; Region: COG4279
323097008381	SWIM zinc finger; Region: SWIM; pfam04434
323097008382	SNF2 Helicase protein; Region: DUF3670; pfam12419
323097008383	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
323097008384	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097008385	ATP binding site [chemical binding]; other site
323097008386	putative Mg++ binding site [ion binding]; other site
323097008387	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097008388	nucleotide binding region [chemical binding]; other site
323097008389	ATP-binding site [chemical binding]; other site
323097008390	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
323097008391	AAA domain; Region: AAA_30; pfam13604
323097008392	Family description; Region: UvrD_C_2; pfam13538
323097008393	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097008394	DNA-binding site [nucleotide binding]; DNA binding site
323097008395	RNA-binding motif; other site
323097008396	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
323097008397	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
323097008398	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
323097008399	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097008400	non-specific DNA binding site [nucleotide binding]; other site
323097008401	salt bridge; other site
323097008402	sequence-specific DNA binding site [nucleotide binding]; other site
323097008403	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
323097008404	RNA/DNA hybrid binding site [nucleotide binding]; other site
323097008405	active site
323097008406	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
323097008407	active site
323097008408	Int/Topo IB signature motif; other site
323097008409	catalytic residues [active]
323097008410	DNA binding site [nucleotide binding]
323097008411	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
323097008412	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
323097008413	active site
323097008414	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
323097008415	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
323097008416	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323097008417	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323097008418	DNA binding residues [nucleotide binding]
323097008419	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323097008420	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323097008421	metal binding site [ion binding]; metal-binding site
323097008422	active site
323097008423	I-site; other site
323097008424	lytic murein transglycosylase; Region: MltB_2; TIGR02283
323097008425	murein hydrolase B; Provisional; Region: PRK10760; cl17906
323097008426	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323097008427	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323097008428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097008429	putative substrate translocation pore; other site
323097008430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097008431	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
323097008432	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
323097008433	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
323097008434	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
323097008435	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323097008436	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
323097008437	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323097008438	DNA binding residues [nucleotide binding]
323097008439	DNA primase, catalytic core; Region: dnaG; TIGR01391
323097008440	CHC2 zinc finger; Region: zf-CHC2; pfam01807
323097008441	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
323097008442	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
323097008443	active site
323097008444	metal binding site [ion binding]; metal-binding site
323097008445	interdomain interaction site; other site
323097008446	N-formylglutamate amidohydrolase; Region: FGase; cl01522
323097008447	Yqey-like protein; Region: YqeY; pfam09424
323097008448	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
323097008449	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
323097008450	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
323097008451	catalytic site [active]
323097008452	subunit interface [polypeptide binding]; other site
323097008453	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
323097008454	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
323097008455	dimerization interface [polypeptide binding]; other site
323097008456	DPS ferroxidase diiron center [ion binding]; other site
323097008457	ion pore; other site
323097008458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097008459	S-adenosylmethionine binding site [chemical binding]; other site
323097008460	Domain of unknown function DUF302; Region: DUF302; cl01364
323097008461	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
323097008462	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323097008463	ATP-grasp domain; Region: ATP-grasp_4; cl17255
323097008464	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
323097008465	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323097008466	ATP-grasp domain; Region: ATP-grasp_4; cl17255
323097008467	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
323097008468	IMP binding site; other site
323097008469	dimer interface [polypeptide binding]; other site
323097008470	interdomain contacts; other site
323097008471	partial ornithine binding site; other site
323097008472	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
323097008473	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
323097008474	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
323097008475	Predicted membrane protein [Function unknown]; Region: COG2259
323097008476	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
323097008477	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323097008478	putative DNA binding site [nucleotide binding]; other site
323097008479	putative Zn2+ binding site [ion binding]; other site
323097008480	AsnC family; Region: AsnC_trans_reg; pfam01037
323097008481	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
323097008482	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
323097008483	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323097008484	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323097008485	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097008486	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
323097008487	putative effector binding pocket; other site
323097008488	dimerization interface [polypeptide binding]; other site
323097008489	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323097008490	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097008491	P-loop; other site
323097008492	Magnesium ion binding site [ion binding]; other site
323097008493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
323097008494	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
323097008495	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
323097008496	Dodecin; Region: Dodecin; pfam07311
323097008497	PRC-barrel domain; Region: PRC; pfam05239
323097008498	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
323097008499	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323097008500	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323097008501	catalytic residue [active]
323097008502	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
323097008503	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
323097008504	thiS-thiF/thiG interaction site; other site
323097008505	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
323097008506	ThiS interaction site; other site
323097008507	putative active site [active]
323097008508	tetramer interface [polypeptide binding]; other site
323097008509	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
323097008510	active site
323097008511	thiamine phosphate binding site [chemical binding]; other site
323097008512	pyrophosphate binding site [ion binding]; other site
323097008513	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
323097008514	ThiC-associated domain; Region: ThiC-associated; pfam13667
323097008515	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
323097008516	Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024
323097008517	Predicted transporter component [General function prediction only]; Region: COG2391
323097008518	Sulphur transport; Region: Sulf_transp; pfam04143
323097008519	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
323097008520	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
323097008521	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
323097008522	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
323097008523	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
323097008524	heme binding site [chemical binding]; other site
323097008525	ferroxidase pore; other site
323097008526	ferroxidase diiron center [ion binding]; other site
323097008527	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
323097008528	lytic murein transglycosylase; Region: MltB_2; TIGR02283
323097008529	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323097008530	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323097008531	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323097008532	hypothetical protein; Provisional; Region: PRK05208
323097008533	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
323097008534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097008535	S-adenosylmethionine binding site [chemical binding]; other site
323097008536	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
323097008537	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
323097008538	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097008539	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097008540	ABC transporter; Region: ABC_tran_2; pfam12848
323097008541	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097008542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323097008543	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097008544	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
323097008545	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
323097008546	active site residue [active]
323097008547	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
323097008548	active site residue [active]
323097008549	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
323097008550	active site
323097008551	catalytic residue [active]
323097008552	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
323097008553	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
323097008554	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323097008555	PAS fold; Region: PAS_7; pfam12860
323097008556	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
323097008557	excinuclease ABC subunit B; Provisional; Region: PRK05298
323097008558	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097008559	ATP binding site [chemical binding]; other site
323097008560	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097008561	nucleotide binding region [chemical binding]; other site
323097008562	ATP-binding site [chemical binding]; other site
323097008563	Ultra-violet resistance protein B; Region: UvrB; pfam12344
323097008564	UvrB/uvrC motif; Region: UVR; pfam02151
323097008565	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
323097008566	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097008567	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097008568	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323097008569	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097008570	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097008571	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097008572	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
323097008573	substrate binding site [chemical binding]; other site
323097008574	active site
323097008575	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
323097008576	CPxP  motif; other site
323097008577	methionine sulfoxide reductase A; Provisional; Region: PRK14054
323097008578	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097008579	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
323097008580	putative dimer interface [polypeptide binding]; other site
323097008581	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
323097008582	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
323097008583	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323097008584	DNA binding residues [nucleotide binding]
323097008585	dimerization interface [polypeptide binding]; other site
323097008586	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
323097008587	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
323097008588	Walker A/P-loop; other site
323097008589	ATP binding site [chemical binding]; other site
323097008590	Q-loop/lid; other site
323097008591	ABC transporter signature motif; other site
323097008592	Walker B; other site
323097008593	D-loop; other site
323097008594	H-loop/switch region; other site
323097008595	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
323097008596	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097008597	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
323097008598	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
323097008599	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
323097008600	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
323097008601	TOBE domain; Region: TOBE; cl01440
323097008602	molybdenum-pterin binding domain; Region: Mop; TIGR00638
323097008603	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
323097008604	nucleotide binding site [chemical binding]; other site
323097008605	substrate binding site [chemical binding]; other site
323097008606	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097008607	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097008608	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097008609	AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255
323097008610	putative nucleotide binding site [chemical binding]; other site
323097008611	putative substrate binding site [chemical binding]; other site
323097008612	Porin subfamily; Region: Porin_2; pfam02530
323097008613	hypothetical protein; Validated; Region: PRK00029
323097008614	Uncharacterized conserved protein [Function unknown]; Region: COG0397
323097008615	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
323097008616	DJ-1 family protein; Region: not_thiJ; TIGR01383
323097008617	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
323097008618	conserved cys residue [active]
323097008619	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
323097008620	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
323097008621	[4Fe-4S] binding site [ion binding]; other site
323097008622	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097008623	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097008624	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097008625	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097008626	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
323097008627	molybdopterin cofactor binding site; other site
323097008628	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
323097008629	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
323097008630	active site
323097008631	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
323097008632	[2Fe-2S] cluster binding site [ion binding]; other site
323097008633	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
323097008634	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323097008635	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
323097008636	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
323097008637	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
323097008638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
323097008639	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
323097008640	metal binding site 2 [ion binding]; metal-binding site
323097008641	putative DNA binding helix; other site
323097008642	metal binding site 1 [ion binding]; metal-binding site
323097008643	dimer interface [polypeptide binding]; other site
323097008644	structural Zn2+ binding site [ion binding]; other site
323097008645	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
323097008646	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
323097008647	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097008648	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097008649	ABC transporter; Region: ABC_tran_2; pfam12848
323097008650	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323097008651	Autotransporter beta-domain; Region: Autotransporter; smart00869
323097008652	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
323097008653	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
323097008654	Sulfatase; Region: Sulfatase; pfam00884
323097008655	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
323097008656	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097008657	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097008658	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
323097008659	Uncharacterized conserved protein [Function unknown]; Region: COG5361
323097008660	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
323097008661	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
323097008662	Uncharacterized conserved protein [Function unknown]; Region: COG5361
323097008663	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
323097008664	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
323097008665	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
323097008666	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097008667	motif II; other site
323097008668	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
323097008669	Uncharacterized conserved protein [Function unknown]; Region: COG1262
323097008670	Helix-turn-helix domain; Region: HTH_18; pfam12833
323097008671	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
323097008672	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097008673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097008674	active site
323097008675	phosphorylation site [posttranslational modification]
323097008676	intermolecular recognition site; other site
323097008677	dimerization interface [polypeptide binding]; other site
323097008678	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097008679	DNA binding site [nucleotide binding]
323097008680	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
323097008681	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
323097008682	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
323097008683	Ligand Binding Site [chemical binding]; other site
323097008684	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
323097008685	GAF domain; Region: GAF_3; pfam13492
323097008686	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097008687	dimer interface [polypeptide binding]; other site
323097008688	phosphorylation site [posttranslational modification]
323097008689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097008690	ATP binding site [chemical binding]; other site
323097008691	Mg2+ binding site [ion binding]; other site
323097008692	G-X-G motif; other site
323097008693	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
323097008694	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
323097008695	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323097008696	Soluble P-type ATPase [General function prediction only]; Region: COG4087
323097008697	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
323097008698	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
323097008699	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
323097008700	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323097008701	Transposase; Region: HTH_Tnp_1; pfam01527
323097008702	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097008703	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097008704	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323097008705	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
323097008706	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323097008707	DNA binding residues [nucleotide binding]
323097008708	dimerization interface [polypeptide binding]; other site
323097008709	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097008710	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097008711	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097008712	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323097008713	Transposase; Region: HTH_Tnp_1; pfam01527
323097008714	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
323097008715	Homeodomain-like domain; Region: HTH_23; pfam13384
323097008716	Winged helix-turn helix; Region: HTH_29; pfam13551
323097008717	Homeodomain-like domain; Region: HTH_32; pfam13565
323097008718	Transposase, Mutator family; Region: Transposase_mut; pfam00872
323097008719	MULE transposase domain; Region: MULE; pfam10551
323097008720	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
323097008721	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
323097008722	NAD binding site [chemical binding]; other site
323097008723	homodimer interface [polypeptide binding]; other site
323097008724	active site
323097008725	substrate binding site [chemical binding]; other site
323097008726	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
323097008727	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
323097008728	active site
323097008729	metal binding site [ion binding]; metal-binding site
323097008730	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
323097008731	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097008732	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097008733	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
323097008734	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323097008735	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097008736	Walker A/P-loop; other site
323097008737	ATP binding site [chemical binding]; other site
323097008738	Q-loop/lid; other site
323097008739	ABC transporter signature motif; other site
323097008740	Walker B; other site
323097008741	D-loop; other site
323097008742	H-loop/switch region; other site
323097008743	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
323097008744	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
323097008745	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
323097008746	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
323097008747	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
323097008748	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
323097008749	Methyltransferase domain; Region: Methyltransf_11; pfam08241
323097008750	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323097008751	Acyltransferase family; Region: Acyl_transf_3; pfam01757
323097008752	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
323097008753	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
323097008754	Probable Catalytic site; other site
323097008755	metal-binding site
323097008756	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323097008757	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323097008758	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
323097008759	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
323097008760	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
323097008761	inhibitor-cofactor binding pocket; inhibition site
323097008762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097008763	catalytic residue [active]
323097008764	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
323097008765	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323097008766	NAD(P) binding site [chemical binding]; other site
323097008767	active site
323097008768	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
323097008769	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
323097008770	inhibitor-cofactor binding pocket; inhibition site
323097008771	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097008772	catalytic residue [active]
323097008773	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
323097008774	putative trimer interface [polypeptide binding]; other site
323097008775	putative active site [active]
323097008776	putative substrate binding site [chemical binding]; other site
323097008777	putative CoA binding site [chemical binding]; other site
323097008778	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
323097008779	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
323097008780	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
323097008781	trimer interface [polypeptide binding]; other site
323097008782	active site
323097008783	substrate binding site [chemical binding]; other site
323097008784	CoA binding site [chemical binding]; other site
323097008785	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
323097008786	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
323097008787	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
323097008788	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
323097008789	TrkA-N domain; Region: TrkA_N; pfam02254
323097008790	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
323097008791	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
323097008792	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
323097008793	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
323097008794	active site
323097008795	homodimer interface [polypeptide binding]; other site
323097008796	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
323097008797	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
323097008798	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
323097008799	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323097008800	active site
323097008801	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
323097008802	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097008803	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097008804	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
323097008805	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
323097008806	putative active site [active]
323097008807	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323097008808	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097008809	Walker A/P-loop; other site
323097008810	ATP binding site [chemical binding]; other site
323097008811	Q-loop/lid; other site
323097008812	ABC transporter signature motif; other site
323097008813	Walker B; other site
323097008814	D-loop; other site
323097008815	H-loop/switch region; other site
323097008816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097008817	S-adenosylmethionine binding site [chemical binding]; other site
323097008818	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
323097008819	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
323097008820	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
323097008821	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
323097008822	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
323097008823	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
323097008824	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
323097008825	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
323097008826	substrate binding site; other site
323097008827	tetramer interface; other site
323097008828	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
323097008829	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
323097008830	NADP binding site [chemical binding]; other site
323097008831	active site
323097008832	putative substrate binding site [chemical binding]; other site
323097008833	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
323097008834	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
323097008835	NAD binding site [chemical binding]; other site
323097008836	substrate binding site [chemical binding]; other site
323097008837	homodimer interface [polypeptide binding]; other site
323097008838	active site
323097008839	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
323097008840	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
323097008841	Chain length determinant protein; Region: Wzz; pfam02706
323097008842	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
323097008843	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
323097008844	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097008845	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097008846	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097008847	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097008848	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097008849	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097008850	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097008851	Homeodomain-like domain; Region: HTH_23; pfam13384
323097008852	Winged helix-turn helix; Region: HTH_29; pfam13551
323097008853	Homeodomain-like domain; Region: HTH_32; pfam13565
323097008854	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
323097008855	Bacterial sugar transferase; Region: Bac_transf; pfam02397
323097008856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
323097008857	H-NS histone family; Region: Histone_HNS; pfam00816
323097008858	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
323097008859	H-NS histone family; Region: Histone_HNS; pfam00816
323097008860	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
323097008861	Resolvase, N terminal domain; Region: Resolvase; smart00857
323097008862	catalytic nucleophile [active]
323097008863	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097008864	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097008865	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323097008866	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
323097008867	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
323097008868	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097008869	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097008870	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097008871	Transposase; Region: HTH_Tnp_1; cl17663
323097008872	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097008873	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097008874	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097008875	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097008876	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097008877	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097008878	Autotransporter beta-domain; Region: Autotransporter; smart00869
323097008879	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097008880	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097008881	DNA binding site [nucleotide binding]
323097008882	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097008883	binding surface
323097008884	TPR motif; other site
323097008885	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097008886	binding surface
323097008887	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097008888	TPR motif; other site
323097008889	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
323097008890	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
323097008891	Catalytic site; other site
323097008892	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
323097008893	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
323097008894	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323097008895	active site
323097008896	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
323097008897	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
323097008898	Uncharacterized conserved protein [Function unknown]; Region: COG1565
323097008899	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
323097008900	Membrane fusogenic activity; Region: BMFP; pfam04380
323097008901	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
323097008902	putative active site [active]
323097008903	putative catalytic site [active]
323097008904	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
323097008905	putative active site [active]
323097008906	putative catalytic site [active]
323097008907	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
323097008908	GTP-binding protein YchF; Reviewed; Region: PRK09601
323097008909	YchF GTPase; Region: YchF; cd01900
323097008910	G1 box; other site
323097008911	GTP/Mg2+ binding site [chemical binding]; other site
323097008912	Switch I region; other site
323097008913	G2 box; other site
323097008914	Switch II region; other site
323097008915	G3 box; other site
323097008916	G4 box; other site
323097008917	G5 box; other site
323097008918	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
323097008919	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
323097008920	putative active site [active]
323097008921	catalytic residue [active]
323097008922	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
323097008923	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
323097008924	5S rRNA interface [nucleotide binding]; other site
323097008925	CTC domain interface [polypeptide binding]; other site
323097008926	L16 interface [polypeptide binding]; other site
323097008927	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
323097008928	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
323097008929	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
323097008930	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
323097008931	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323097008932	E3 interaction surface; other site
323097008933	lipoyl attachment site [posttranslational modification]; other site
323097008934	e3 binding domain; Region: E3_binding; pfam02817
323097008935	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
323097008936	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
323097008937	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
323097008938	alpha subunit interface [polypeptide binding]; other site
323097008939	TPP binding site [chemical binding]; other site
323097008940	heterodimer interface [polypeptide binding]; other site
323097008941	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
323097008942	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
323097008943	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
323097008944	TPP-binding site [chemical binding]; other site
323097008945	tetramer interface [polypeptide binding]; other site
323097008946	heterodimer interface [polypeptide binding]; other site
323097008947	phosphorylation loop region [posttranslational modification]
323097008948	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
323097008949	aldehyde dehydrogenase family 7 member; Region: PLN02315
323097008950	tetrameric interface [polypeptide binding]; other site
323097008951	NAD binding site [chemical binding]; other site
323097008952	catalytic residues [active]
323097008953	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
323097008954	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
323097008955	inhibitor-cofactor binding pocket; inhibition site
323097008956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097008957	catalytic residue [active]
323097008958	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
323097008959	putative deacylase active site [active]
323097008960	Transposase domain (DUF772); Region: DUF772; pfam05598
323097008961	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097008962	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097008963	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323097008964	Ligand Binding Site [chemical binding]; other site
323097008965	Protein of unknown function (DUF982); Region: DUF982; pfam06169
323097008966	PcfJ-like protein; Region: PcfJ; pfam14284
323097008967	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
323097008968	4Fe-4S binding domain; Region: Fer4; pfam00037
323097008969	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
323097008970	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
323097008971	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
323097008972	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
323097008973	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
323097008974	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
323097008975	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
323097008976	[4Fe-4S] binding site [ion binding]; other site
323097008977	molybdopterin cofactor binding site; other site
323097008978	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097008979	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
323097008980	molybdopterin cofactor binding site; other site
323097008981	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
323097008982	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
323097008983	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
323097008984	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
323097008985	CPxP  motif; other site
323097008986	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
323097008987	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
323097008988	dimer interface [polypeptide binding]; other site
323097008989	putative functional site; other site
323097008990	putative MPT binding site; other site
323097008991	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
323097008992	Walker A motif; other site
323097008993	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
323097008994	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
323097008995	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
323097008996	GTP binding site; other site
323097008997	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
323097008998	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
323097008999	dimer interface [polypeptide binding]; other site
323097009000	putative functional site; other site
323097009001	putative MPT binding site; other site
323097009002	PBP superfamily domain; Region: PBP_like; pfam12727
323097009003	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
323097009004	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
323097009005	MPT binding site; other site
323097009006	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097009007	HAMP domain; Region: HAMP; pfam00672
323097009008	dimerization interface [polypeptide binding]; other site
323097009009	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097009010	dimer interface [polypeptide binding]; other site
323097009011	phosphorylation site [posttranslational modification]
323097009012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097009013	ATP binding site [chemical binding]; other site
323097009014	Mg2+ binding site [ion binding]; other site
323097009015	G-X-G motif; other site
323097009016	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097009017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097009018	active site
323097009019	phosphorylation site [posttranslational modification]
323097009020	intermolecular recognition site; other site
323097009021	dimerization interface [polypeptide binding]; other site
323097009022	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097009023	DNA binding site [nucleotide binding]
323097009024	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
323097009025	MarR family; Region: MarR_2; pfam12802
323097009026	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
323097009027	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
323097009028	homodimer interface [polypeptide binding]; other site
323097009029	substrate-cofactor binding pocket; other site
323097009030	catalytic residue [active]
323097009031	Transposase domain (DUF772); Region: DUF772; pfam05598
323097009032	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097009033	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097009034	multidrug efflux protein; Reviewed; Region: PRK01766
323097009035	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
323097009036	cation binding site [ion binding]; other site
323097009037	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
323097009038	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097009039	S-adenosylmethionine binding site [chemical binding]; other site
323097009040	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
323097009041	MoaE homodimer interface [polypeptide binding]; other site
323097009042	MoaD interaction [polypeptide binding]; other site
323097009043	active site residues [active]
323097009044	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
323097009045	MoaE interaction surface [polypeptide binding]; other site
323097009046	MoeB interaction surface [polypeptide binding]; other site
323097009047	thiocarboxylated glycine; other site
323097009048	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
323097009049	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
323097009050	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
323097009051	GIY-YIG motif/motif A; other site
323097009052	active site
323097009053	catalytic site [active]
323097009054	putative DNA binding site [nucleotide binding]; other site
323097009055	metal binding site [ion binding]; metal-binding site
323097009056	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
323097009057	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323097009058	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097009059	DNA-binding site [nucleotide binding]; DNA binding site
323097009060	RNA-binding motif; other site
323097009061	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
323097009062	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
323097009063	B1 nucleotide binding pocket [chemical binding]; other site
323097009064	B2 nucleotide binding pocket [chemical binding]; other site
323097009065	CAS motifs; other site
323097009066	active site
323097009067	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
323097009068	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
323097009069	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
323097009070	dimer interface [polypeptide binding]; other site
323097009071	motif 1; other site
323097009072	motif 2; other site
323097009073	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323097009074	active site
323097009075	motif 3; other site
323097009076	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
323097009077	anticodon binding site; other site
323097009078	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
323097009079	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
323097009080	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
323097009081	inhibitor-cofactor binding pocket; inhibition site
323097009082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323097009083	catalytic residue [active]
323097009084	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323097009085	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
323097009086	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097009087	active site
323097009088	motif I; other site
323097009089	motif II; other site
323097009090	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
323097009091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097009092	Response regulator receiver domain; Region: Response_reg; pfam00072
323097009093	active site
323097009094	phosphorylation site [posttranslational modification]
323097009095	intermolecular recognition site; other site
323097009096	dimerization interface [polypeptide binding]; other site
323097009097	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
323097009098	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
323097009099	active site
323097009100	Riboflavin kinase; Region: Flavokinase; smart00904
323097009101	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
323097009102	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323097009103	active site
323097009104	HIGH motif; other site
323097009105	nucleotide binding site [chemical binding]; other site
323097009106	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
323097009107	active site
323097009108	KMSKS motif; other site
323097009109	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
323097009110	tRNA binding surface [nucleotide binding]; other site
323097009111	anticodon binding site; other site
323097009112	lipoprotein signal peptidase; Provisional; Region: PRK14796
323097009113	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
323097009114	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
323097009115	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
323097009116	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
323097009117	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
323097009118	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
323097009119	hypothetical protein; Provisional; Region: PRK09256
323097009120	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
323097009121	Homeodomain-like domain; Region: HTH_23; pfam13384
323097009122	Winged helix-turn helix; Region: HTH_29; pfam13551
323097009123	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097009124	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097009125	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
323097009126	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
323097009127	ATP binding site [chemical binding]; other site
323097009128	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
323097009129	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
323097009130	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323097009131	S-adenosylmethionine binding site [chemical binding]; other site
323097009132	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
323097009133	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323097009134	RNA binding surface [nucleotide binding]; other site
323097009135	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
323097009136	active site
323097009137	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
323097009138	nucleoside/Zn binding site; other site
323097009139	dimer interface [polypeptide binding]; other site
323097009140	catalytic motif [active]
323097009141	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
323097009142	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
323097009143	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
323097009144	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
323097009145	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
323097009146	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
323097009147	generic binding surface II; other site
323097009148	generic binding surface I; other site
323097009149	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
323097009150	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
323097009151	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
323097009152	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
323097009153	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
323097009154	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
323097009155	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
323097009156	putative acyl-acceptor binding pocket; other site
323097009157	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
323097009158	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
323097009159	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
323097009160	active site
323097009161	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
323097009162	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
323097009163	UbiA prenyltransferase family; Region: UbiA; pfam01040
323097009164	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
323097009165	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
323097009166	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323097009167	motif 1; other site
323097009168	dimer interface [polypeptide binding]; other site
323097009169	active site
323097009170	motif 2; other site
323097009171	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323097009172	active site
323097009173	motif 3; other site
323097009174	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
323097009175	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
323097009176	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
323097009177	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
323097009178	Ligand binding site; other site
323097009179	Putative Catalytic site; other site
323097009180	DXD motif; other site
323097009181	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
323097009182	putative active site [active]
323097009183	YdjC motif; other site
323097009184	Mg binding site [ion binding]; other site
323097009185	putative homodimer interface [polypeptide binding]; other site
323097009186	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
323097009187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323097009188	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097009189	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
323097009190	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
323097009191	oligomerisation interface [polypeptide binding]; other site
323097009192	mobile loop; other site
323097009193	roof hairpin; other site
323097009194	chaperonin GroEL; Reviewed; Region: groEL; PRK12852
323097009195	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
323097009196	ring oligomerisation interface [polypeptide binding]; other site
323097009197	ATP/Mg binding site [chemical binding]; other site
323097009198	stacking interactions; other site
323097009199	hinge regions; other site
323097009200	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
323097009201	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
323097009202	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
323097009203	Cysteine-rich domain; Region: CCG; pfam02754
323097009204	Cysteine-rich domain; Region: CCG; pfam02754
323097009205	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
323097009206	FAD binding domain; Region: FAD_binding_4; pfam01565
323097009207	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
323097009208	FAD binding domain; Region: FAD_binding_4; pfam01565
323097009209	Cytochrome c; Region: Cytochrom_C; cl11414
323097009210	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323097009211	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323097009212	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
323097009213	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
323097009214	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
323097009215	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
323097009216	dimer interface [polypeptide binding]; other site
323097009217	motif 1; other site
323097009218	active site
323097009219	motif 2; other site
323097009220	motif 3; other site
323097009221	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
323097009222	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
323097009223	tandem repeat interface [polypeptide binding]; other site
323097009224	oligomer interface [polypeptide binding]; other site
323097009225	active site residues [active]
323097009226	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
323097009227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
323097009228	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
323097009229	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
323097009230	substrate binding pocket [chemical binding]; other site
323097009231	chain length determination region; other site
323097009232	substrate-Mg2+ binding site; other site
323097009233	catalytic residues [active]
323097009234	aspartate-rich region 1; other site
323097009235	active site lid residues [active]
323097009236	aspartate-rich region 2; other site
323097009237	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
323097009238	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
323097009239	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
323097009240	binding surface
323097009241	TPR motif; other site
323097009242	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097009243	binding surface
323097009244	TPR motif; other site
323097009245	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097009246	binding surface
323097009247	TPR motif; other site
323097009248	TPR repeat; Region: TPR_11; pfam13414
323097009249	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097009250	binding surface
323097009251	TPR motif; other site
323097009252	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
323097009253	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323097009254	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
323097009255	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
323097009256	Fe-S cluster binding site [ion binding]; other site
323097009257	active site
323097009258	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
323097009259	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
323097009260	RNA/DNA hybrid binding site [nucleotide binding]; other site
323097009261	active site
323097009262	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
323097009263	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097009264	FeS/SAM binding site; other site
323097009265	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
323097009266	MPT binding site; other site
323097009267	trimer interface [polypeptide binding]; other site
323097009268	Predicted metalloprotease [General function prediction only]; Region: COG2321
323097009269	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
323097009270	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
323097009271	DNA methylase; Region: N6_N4_Mtase; pfam01555
323097009272	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323097009273	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
323097009274	C-terminal domain interface [polypeptide binding]; other site
323097009275	GSH binding site (G-site) [chemical binding]; other site
323097009276	dimer interface [polypeptide binding]; other site
323097009277	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
323097009278	N-terminal domain interface [polypeptide binding]; other site
323097009279	dimer interface [polypeptide binding]; other site
323097009280	substrate binding pocket (H-site) [chemical binding]; other site
323097009281	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
323097009282	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
323097009283	minor groove reading motif; other site
323097009284	helix-hairpin-helix signature motif; other site
323097009285	active site
323097009286	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
323097009287	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
323097009288	DNA binding and oxoG recognition site [nucleotide binding]
323097009289	Protein of unknown function (DUF721); Region: DUF721; cl02324
323097009290	Thioredoxin; Region: Thioredoxin_4; pfam13462
323097009291	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
323097009292	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
323097009293	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
323097009294	Walker A/P-loop; other site
323097009295	ATP binding site [chemical binding]; other site
323097009296	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
323097009297	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
323097009298	ABC transporter signature motif; other site
323097009299	Walker B; other site
323097009300	D-loop; other site
323097009301	H-loop/switch region; other site
323097009302	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
323097009303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
323097009304	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
323097009305	Peptidase family M48; Region: Peptidase_M48; cl12018
323097009306	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
323097009307	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323097009308	active site
323097009309	anthranilate synthase; Provisional; Region: PRK13566
323097009310	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
323097009311	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
323097009312	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
323097009313	glutamine binding [chemical binding]; other site
323097009314	catalytic triad [active]
323097009315	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
323097009316	substrate binding site [chemical binding]; other site
323097009317	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
323097009318	cytochrome b; Provisional; Region: CYTB; MTH00156
323097009319	Qi binding site; other site
323097009320	intrachain domain interface; other site
323097009321	interchain domain interface [polypeptide binding]; other site
323097009322	heme bH binding site [chemical binding]; other site
323097009323	heme bL binding site [chemical binding]; other site
323097009324	Qo binding site; other site
323097009325	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
323097009326	interchain domain interface [polypeptide binding]; other site
323097009327	intrachain domain interface; other site
323097009328	Qi binding site; other site
323097009329	Qo binding site; other site
323097009330	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
323097009331	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
323097009332	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
323097009333	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
323097009334	[2Fe-2S] cluster binding site [ion binding]; other site
323097009335	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
323097009336	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
323097009337	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097009338	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
323097009339	active site
323097009340	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097009341	binding surface
323097009342	TPR motif; other site
323097009343	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097009344	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097009345	binding surface
323097009346	TPR motif; other site
323097009347	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323097009348	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
323097009349	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
323097009350	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
323097009351	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
323097009352	active site
323097009353	NTP binding site [chemical binding]; other site
323097009354	metal binding triad [ion binding]; metal-binding site
323097009355	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
323097009356	putative active site [active]
323097009357	putative CoA binding site [chemical binding]; other site
323097009358	nudix motif; other site
323097009359	metal binding site [ion binding]; metal-binding site
323097009360	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
323097009361	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
323097009362	MoxR-like ATPases [General function prediction only]; Region: COG0714
323097009363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097009364	Walker A motif; other site
323097009365	ATP binding site [chemical binding]; other site
323097009366	Walker B motif; other site
323097009367	arginine finger; other site
323097009368	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
323097009369	Protein of unknown function DUF58; Region: DUF58; pfam01882
323097009370	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
323097009371	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
323097009372	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
323097009373	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
323097009374	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
323097009375	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323097009376	Coenzyme A binding pocket [chemical binding]; other site
323097009377	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
323097009378	nudix motif; other site
323097009379	Uncharacterized conserved protein [Function unknown]; Region: COG1633
323097009380	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
323097009381	diiron binding motif [ion binding]; other site
323097009382	Uncharacterized conserved protein [Function unknown]; Region: COG1633
323097009383	CCC1-related family of proteins; Region: CCC1_like; cl00278
323097009384	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323097009385	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
323097009386	active site
323097009387	metal binding site [ion binding]; metal-binding site
323097009388	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323097009389	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097009390	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
323097009391	nucleoside/Zn binding site; other site
323097009392	dimer interface [polypeptide binding]; other site
323097009393	catalytic motif [active]
323097009394	Protein of unknown function, DUF486; Region: DUF486; cl01236
323097009395	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
323097009396	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
323097009397	catalytic residues [active]
323097009398	dimer interface [polypeptide binding]; other site
323097009399	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
323097009400	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
323097009401	putative active site [active]
323097009402	catalytic residue [active]
323097009403	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
323097009404	active site
323097009405	dimer interface [polypeptide binding]; other site
323097009406	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
323097009407	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
323097009408	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
323097009409	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
323097009410	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
323097009411	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
323097009412	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
323097009413	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
323097009414	putative active site [active]
323097009415	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
323097009416	AAA domain; Region: AAA_33; pfam13671
323097009417	ATP-binding site [chemical binding]; other site
323097009418	Gluconate-6-phosphate binding site [chemical binding]; other site
323097009419	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
323097009420	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
323097009421	active site
323097009422	motif I; other site
323097009423	motif II; other site
323097009424	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
323097009425	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
323097009426	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
323097009427	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
323097009428	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323097009429	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323097009430	metal binding site [ion binding]; metal-binding site
323097009431	active site
323097009432	I-site; other site
323097009433	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323097009434	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
323097009435	Uncharacterized conserved protein [Function unknown]; Region: COG2128
323097009436	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
323097009437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097009438	putative substrate translocation pore; other site
323097009439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097009440	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
323097009441	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097009442	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097009443	LysR family transcriptional regulator; Provisional; Region: PRK14997
323097009444	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097009445	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
323097009446	putative effector binding pocket; other site
323097009447	dimerization interface [polypeptide binding]; other site
323097009448	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
323097009449	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
323097009450	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323097009451	Cytochrome c; Region: Cytochrom_C; pfam00034
323097009452	Cytochrome c; Region: Cytochrom_C; pfam00034
323097009453	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
323097009454	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
323097009455	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
323097009456	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323097009457	TPR motif; other site
323097009458	binding surface
323097009459	Transcriptional regulator; Region: Rrf2; cl17282
323097009460	Rrf2 family protein; Region: rrf2_super; TIGR00738
323097009461	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
323097009462	The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759
323097009463	putative [Fe4-S4] binding site [ion binding]; other site
323097009464	putative molybdopterin cofactor binding site [chemical binding]; other site
323097009465	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
323097009466	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097009467	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
323097009468	putative molybdopterin cofactor binding site; other site
323097009469	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
323097009470	Transposase domain (DUF772); Region: DUF772; pfam05598
323097009471	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097009472	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097009473	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
323097009474	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097009475	N-terminal plug; other site
323097009476	ligand-binding site [chemical binding]; other site
323097009477	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097009478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097009479	active site
323097009480	phosphorylation site [posttranslational modification]
323097009481	intermolecular recognition site; other site
323097009482	dimerization interface [polypeptide binding]; other site
323097009483	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097009484	DNA binding site [nucleotide binding]
323097009485	sensor protein QseC; Provisional; Region: PRK10337
323097009486	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097009487	dimer interface [polypeptide binding]; other site
323097009488	phosphorylation site [posttranslational modification]
323097009489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097009490	ATP binding site [chemical binding]; other site
323097009491	Mg2+ binding site [ion binding]; other site
323097009492	G-X-G motif; other site
323097009493	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
323097009494	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
323097009495	dimerization interface [polypeptide binding]; other site
323097009496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097009497	dimer interface [polypeptide binding]; other site
323097009498	phosphorylation site [posttranslational modification]
323097009499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097009500	ATP binding site [chemical binding]; other site
323097009501	Mg2+ binding site [ion binding]; other site
323097009502	G-X-G motif; other site
323097009503	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097009504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097009505	active site
323097009506	phosphorylation site [posttranslational modification]
323097009507	intermolecular recognition site; other site
323097009508	dimerization interface [polypeptide binding]; other site
323097009509	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097009510	DNA binding site [nucleotide binding]
323097009511	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323097009512	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
323097009513	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097009514	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
323097009515	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
323097009516	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
323097009517	heme-binding site [chemical binding]; other site
323097009518	Sulfatase; Region: Sulfatase; cl17466
323097009519	Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529
323097009520	ligand binding site [chemical binding]; other site
323097009521	putative catalytic site [active]
323097009522	Methyltransferase domain; Region: Methyltransf_24; pfam13578
323097009523	PRC-barrel domain; Region: PRC; pfam05239
323097009524	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
323097009525	active site
323097009526	catalytic residues [active]
323097009527	DNA binding site [nucleotide binding]
323097009528	Int/Topo IB signature motif; other site
323097009529	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
323097009530	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
323097009531	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
323097009532	Phage Tail Protein X; Region: Phage_tail_X; cl02088
323097009533	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
323097009534	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
323097009535	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
323097009536	Phage tail tube protein FII; Region: Phage_tube; pfam04985
323097009537	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
323097009538	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
323097009539	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
323097009540	long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584
323097009541	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
323097009542	Baseplate J-like protein; Region: Baseplate_J; cl01294
323097009543	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
323097009544	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
323097009545	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
323097009546	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
323097009547	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
323097009548	Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220
323097009549	Low affinity iron permease; Region: Iron_permease; pfam04120
323097009550	Transcription termination factor nusG; Region: NusG; pfam02357
323097009551	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
323097009552	active site
323097009553	metal binding site [ion binding]; metal-binding site
323097009554	interdomain interaction site; other site
323097009555	AAA domain; Region: AAA_25; pfam13481
323097009556	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323097009557	Walker A motif; other site
323097009558	ATP binding site [chemical binding]; other site
323097009559	Walker B motif; other site
323097009560	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097009561	non-specific DNA binding site [nucleotide binding]; other site
323097009562	salt bridge; other site
323097009563	sequence-specific DNA binding site [nucleotide binding]; other site
323097009564	Predicted transcriptional regulator [Transcription]; Region: COG2932
323097009565	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
323097009566	Catalytic site [active]
323097009567	Peptidase propeptide and YPEB domain; Region: PepSY_2; cl17877
323097009568	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097009569	sequence-specific DNA binding site [nucleotide binding]; other site
323097009570	salt bridge; other site
323097009571	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
323097009572	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
323097009573	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
323097009574	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
323097009575	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
323097009576	active site
323097009577	catalytic residues [active]
323097009578	DNA binding site [nucleotide binding]
323097009579	Int/Topo IB signature motif; other site
323097009580	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323097009581	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097009582	N-terminal plug; other site
323097009583	ligand-binding site [chemical binding]; other site
323097009584	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
323097009585	FHIPEP family; Region: FHIPEP; pfam00771
323097009586	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
323097009587	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
323097009588	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
323097009589	Walker A motif/ATP binding site; other site
323097009590	Walker B motif; other site
323097009591	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323097009592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097009593	active site
323097009594	phosphorylation site [posttranslational modification]
323097009595	intermolecular recognition site; other site
323097009596	dimerization interface [polypeptide binding]; other site
323097009597	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097009598	DNA binding site [nucleotide binding]
323097009599	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
323097009600	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
323097009601	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
323097009602	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
323097009603	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097009604	active site
323097009605	phosphorylation site [posttranslational modification]
323097009606	intermolecular recognition site; other site
323097009607	dimerization interface [polypeptide binding]; other site
323097009608	CheB methylesterase; Region: CheB_methylest; pfam01339
323097009609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097009610	Response regulator receiver domain; Region: Response_reg; pfam00072
323097009611	active site
323097009612	phosphorylation site [posttranslational modification]
323097009613	intermolecular recognition site; other site
323097009614	dimerization interface [polypeptide binding]; other site
323097009615	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
323097009616	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
323097009617	putative binding surface; other site
323097009618	active site
323097009619	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
323097009620	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
323097009621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097009622	ATP binding site [chemical binding]; other site
323097009623	Mg2+ binding site [ion binding]; other site
323097009624	G-X-G motif; other site
323097009625	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
323097009626	CheW-like domain; Region: CheW; pfam01584
323097009627	Response regulator receiver domain; Region: Response_reg; pfam00072
323097009628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097009629	active site
323097009630	phosphorylation site [posttranslational modification]
323097009631	intermolecular recognition site; other site
323097009632	dimerization interface [polypeptide binding]; other site
323097009633	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
323097009634	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
323097009635	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
323097009636	active site
323097009637	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
323097009638	Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253
323097009639	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
323097009640	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323097009641	active site
323097009642	metal binding site [ion binding]; metal-binding site
323097009643	hypothetical protein; Validated; Region: PRK07586
323097009644	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
323097009645	PYR/PP interface [polypeptide binding]; other site
323097009646	dimer interface [polypeptide binding]; other site
323097009647	TPP binding site [chemical binding]; other site
323097009648	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
323097009649	TPP-binding site [chemical binding]; other site
323097009650	dimer interface [polypeptide binding]; other site
323097009651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323097009652	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097009653	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
323097009654	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
323097009655	isovaleryl-CoA dehydrogenase; Region: PLN02519
323097009656	substrate binding site [chemical binding]; other site
323097009657	FAD binding site [chemical binding]; other site
323097009658	catalytic base [active]
323097009659	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
323097009660	YcjX-like family, DUF463; Region: DUF463; pfam04317
323097009661	hypothetical protein; Provisional; Region: PRK05415
323097009662	Domain of unknown function (DUF697); Region: DUF697; cl12064
323097009663	Transposase domain (DUF772); Region: DUF772; pfam05598
323097009664	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097009665	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097009666	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
323097009667	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
323097009668	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
323097009669	sulfite oxidase; Provisional; Region: PLN00177
323097009670	Moco binding site; other site
323097009671	metal coordination site [ion binding]; other site
323097009672	Cytochrome c; Region: Cytochrom_C; cl11414
323097009673	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097009674	DNA-binding site [nucleotide binding]; DNA binding site
323097009675	RNA-binding motif; other site
323097009676	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
323097009677	Proline dehydrogenase; Region: Pro_dh; pfam01619
323097009678	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
323097009679	Glutamate binding site [chemical binding]; other site
323097009680	NAD binding site [chemical binding]; other site
323097009681	catalytic residues [active]
323097009682	Repair protein; Region: Repair_PSII; cl01535
323097009683	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
323097009684	Repair protein; Region: Repair_PSII; pfam04536
323097009685	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
323097009686	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
323097009687	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
323097009688	active site
323097009689	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
323097009690	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
323097009691	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323097009692	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323097009693	active site
323097009694	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
323097009695	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
323097009696	Mechanosensitive ion channel; Region: MS_channel; pfam00924
323097009697	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
323097009698	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
323097009699	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
323097009700	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
323097009701	N- and C-terminal domain interface [polypeptide binding]; other site
323097009702	active site
323097009703	MgATP binding site [chemical binding]; other site
323097009704	catalytic site [active]
323097009705	metal binding site [ion binding]; metal-binding site
323097009706	carbohydrate binding site [chemical binding]; other site
323097009707	putative homodimer interface [polypeptide binding]; other site
323097009708	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
323097009709	KpsF/GutQ family protein; Region: kpsF; TIGR00393
323097009710	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
323097009711	putative active site [active]
323097009712	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
323097009713	Transposase domain (DUF772); Region: DUF772; pfam05598
323097009714	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097009715	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097009716	ferrochelatase; Reviewed; Region: hemH; PRK00035
323097009717	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
323097009718	C-terminal domain interface [polypeptide binding]; other site
323097009719	active site
323097009720	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
323097009721	active site
323097009722	N-terminal domain interface [polypeptide binding]; other site
323097009723	MAPEG family; Region: MAPEG; cl09190
323097009724	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
323097009725	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
323097009726	active site
323097009727	Zn binding site [ion binding]; other site
323097009728	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
323097009729	dimer interface [polypeptide binding]; other site
323097009730	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
323097009731	active site
323097009732	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323097009733	catalytic residues [active]
323097009734	substrate binding site [chemical binding]; other site
323097009735	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323097009736	Coenzyme A binding pocket [chemical binding]; other site
323097009737	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
323097009738	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
323097009739	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
323097009740	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
323097009741	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
323097009742	FOG: WD40 repeat [General function prediction only]; Region: COG2319
323097009743	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
323097009744	structural tetrad; other site
323097009745	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
323097009746	structural tetrad; other site
323097009747	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
323097009748	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
323097009749	P-loop, Walker A motif; other site
323097009750	Base recognition motif; other site
323097009751	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
323097009752	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
323097009753	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
323097009754	metal binding site [ion binding]; metal-binding site
323097009755	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
323097009756	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
323097009757	ABC-ATPase subunit  interface; other site
323097009758	dimer interface [polypeptide binding]; other site
323097009759	putative PBP binding regions; other site
323097009760	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
323097009761	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
323097009762	camphor resistance protein CrcB; Provisional; Region: PRK14198
323097009763	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
323097009764	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
323097009765	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
323097009766	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
323097009767	YHS domain; Region: YHS; pfam04945
323097009768	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
323097009769	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323097009770	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097009771	motif II; other site
323097009772	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
323097009773	putative homodimer interface [polypeptide binding]; other site
323097009774	putative homotetramer interface [polypeptide binding]; other site
323097009775	putative allosteric switch controlling residues; other site
323097009776	putative metal binding site [ion binding]; other site
323097009777	putative homodimer-homodimer interface [polypeptide binding]; other site
323097009778	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323097009779	DNA-binding site [nucleotide binding]; DNA binding site
323097009780	RNA-binding motif; other site
323097009781	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097009782	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097009783	Winged helix-turn helix; Region: HTH_29; pfam13551
323097009784	Homeodomain-like domain; Region: HTH_23; cl17451
323097009785	Homeodomain-like domain; Region: HTH_32; pfam13565
323097009786	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
323097009787	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323097009788	ATP binding site [chemical binding]; other site
323097009789	putative Mg++ binding site [ion binding]; other site
323097009790	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097009791	nucleotide binding region [chemical binding]; other site
323097009792	ATP-binding site [chemical binding]; other site
323097009793	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
323097009794	HRDC domain; Region: HRDC; pfam00570
323097009795	Transposase domain (DUF772); Region: DUF772; pfam05598
323097009796	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097009797	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097009798	Integrase core domain; Region: rve_3; cl15866
323097009799	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
323097009800	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
323097009801	gating phenylalanine in ion channel; other site
323097009802	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097009803	putative substrate translocation pore; other site
323097009804	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
323097009805	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
323097009806	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
323097009807	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
323097009808	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
323097009809	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
323097009810	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
323097009811	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
323097009812	[4Fe-4S] binding site [ion binding]; other site
323097009813	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097009814	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097009815	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097009816	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323097009817	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
323097009818	molybdopterin cofactor binding site; other site
323097009819	Cytochrome c; Region: Cytochrom_C; pfam00034
323097009820	Cytochrome c; Region: Cytochrom_C; pfam00034
323097009821	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
323097009822	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323097009823	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
323097009824	D-pathway; other site
323097009825	Putative ubiquinol binding site [chemical binding]; other site
323097009826	Low-spin heme (heme b) binding site [chemical binding]; other site
323097009827	Putative water exit pathway; other site
323097009828	Binuclear center (heme o3/CuB) [ion binding]; other site
323097009829	K-pathway; other site
323097009830	Putative proton exit pathway; other site
323097009831	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
323097009832	Subunit I/III interface [polypeptide binding]; other site
323097009833	Subunit III/IV interface [polypeptide binding]; other site
323097009834	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
323097009835	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
323097009836	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
323097009837	Protein of unknown function (DUF983); Region: DUF983; cl02211
323097009838	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
323097009839	Subunit III/VIIa interface [polypeptide binding]; other site
323097009840	Phospholipid binding site [chemical binding]; other site
323097009841	Subunit I/III interface [polypeptide binding]; other site
323097009842	Subunit III/VIb interface [polypeptide binding]; other site
323097009843	Subunit III/VIa interface; other site
323097009844	Subunit III/Vb interface [polypeptide binding]; other site
323097009845	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
323097009846	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
323097009847	UbiA prenyltransferase family; Region: UbiA; pfam01040
323097009848	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323097009849	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
323097009850	Subunit I/III interface [polypeptide binding]; other site
323097009851	D-pathway; other site
323097009852	Subunit I/VIIc interface [polypeptide binding]; other site
323097009853	Subunit I/IV interface [polypeptide binding]; other site
323097009854	Subunit I/II interface [polypeptide binding]; other site
323097009855	Low-spin heme (heme a) binding site [chemical binding]; other site
323097009856	Subunit I/VIIa interface [polypeptide binding]; other site
323097009857	Subunit I/VIa interface [polypeptide binding]; other site
323097009858	Dimer interface; other site
323097009859	Putative water exit pathway; other site
323097009860	Binuclear center (heme a3/CuB) [ion binding]; other site
323097009861	K-pathway; other site
323097009862	Subunit I/Vb interface [polypeptide binding]; other site
323097009863	Putative proton exit pathway; other site
323097009864	Subunit I/VIb interface; other site
323097009865	Subunit I/VIc interface [polypeptide binding]; other site
323097009866	Electron transfer pathway; other site
323097009867	Subunit I/VIIIb interface [polypeptide binding]; other site
323097009868	Subunit I/VIIb interface [polypeptide binding]; other site
323097009869	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
323097009870	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
323097009871	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
323097009872	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
323097009873	homodimer interaction site [polypeptide binding]; other site
323097009874	cofactor binding site; other site
323097009875	AAA domain; Region: AAA_17; pfam13207
323097009876	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
323097009877	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
323097009878	P-loop, Walker A motif; other site
323097009879	Base recognition motif; other site
323097009880	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
323097009881	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
323097009882	Cytochrome c2 [Energy production and conversion]; Region: COG3474
323097009883	diaminopimelate decarboxylase; Region: lysA; TIGR01048
323097009884	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
323097009885	active site
323097009886	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323097009887	substrate binding site [chemical binding]; other site
323097009888	catalytic residues [active]
323097009889	dimer interface [polypeptide binding]; other site
323097009890	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
323097009891	argininosuccinate lyase; Provisional; Region: PRK00855
323097009892	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
323097009893	active sites [active]
323097009894	tetramer interface [polypeptide binding]; other site
323097009895	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
323097009896	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323097009897	catalytic residues [active]
323097009898	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
323097009899	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
323097009900	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
323097009901	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
323097009902	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
323097009903	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
323097009904	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
323097009905	Ligand binding site [chemical binding]; other site
323097009906	Electron transfer flavoprotein domain; Region: ETF; pfam01012
323097009907	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
323097009908	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
323097009909	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
323097009910	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097009911	dimer interface [polypeptide binding]; other site
323097009912	phosphorylation site [posttranslational modification]
323097009913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097009914	ATP binding site [chemical binding]; other site
323097009915	Mg2+ binding site [ion binding]; other site
323097009916	G-X-G motif; other site
323097009917	Response regulator receiver domain; Region: Response_reg; pfam00072
323097009918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097009919	active site
323097009920	phosphorylation site [posttranslational modification]
323097009921	intermolecular recognition site; other site
323097009922	dimerization interface [polypeptide binding]; other site
323097009923	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
323097009924	active site
323097009925	HIGH motif; other site
323097009926	nucleotide binding site [chemical binding]; other site
323097009927	active site
323097009928	KMSKS motif; other site
323097009929	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
323097009930	endonuclease III; Region: ENDO3c; smart00478
323097009931	minor groove reading motif; other site
323097009932	helix-hairpin-helix signature motif; other site
323097009933	substrate binding pocket [chemical binding]; other site
323097009934	active site
323097009935	PAS domain S-box; Region: sensory_box; TIGR00229
323097009936	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097009937	putative active site [active]
323097009938	heme pocket [chemical binding]; other site
323097009939	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097009940	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097009941	dimer interface [polypeptide binding]; other site
323097009942	phosphorylation site [posttranslational modification]
323097009943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097009944	ATP binding site [chemical binding]; other site
323097009945	Mg2+ binding site [ion binding]; other site
323097009946	G-X-G motif; other site
323097009947	Response regulator receiver domain; Region: Response_reg; pfam00072
323097009948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097009949	active site
323097009950	phosphorylation site [posttranslational modification]
323097009951	intermolecular recognition site; other site
323097009952	dimerization interface [polypeptide binding]; other site
323097009953	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
323097009954	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
323097009955	active site
323097009956	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
323097009957	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097009958	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323097009959	protein binding site [polypeptide binding]; other site
323097009960	Transcriptional regulator; Region: Rrf2; cl17282
323097009961	Rrf2 family protein; Region: rrf2_super; TIGR00738
323097009962	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
323097009963	apolar tunnel; other site
323097009964	heme binding site [chemical binding]; other site
323097009965	dimerization interface [polypeptide binding]; other site
323097009966	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
323097009967	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
323097009968	catalytic residues [active]
323097009969	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
323097009970	methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280
323097009971	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323097009972	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097009973	N-terminal plug; other site
323097009974	ligand-binding site [chemical binding]; other site
323097009975	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
323097009976	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
323097009977	NADP binding site [chemical binding]; other site
323097009978	dimer interface [polypeptide binding]; other site
323097009979	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097009980	Major Facilitator Superfamily; Region: MFS_1; pfam07690
323097009981	putative substrate translocation pore; other site
323097009982	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
323097009983	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
323097009984	pyruvate phosphate dikinase; Provisional; Region: PRK09279
323097009985	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
323097009986	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
323097009987	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
323097009988	FtsH Extracellular; Region: FtsH_ext; pfam06480
323097009989	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
323097009990	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097009991	Walker A motif; other site
323097009992	ATP binding site [chemical binding]; other site
323097009993	Walker B motif; other site
323097009994	arginine finger; other site
323097009995	Peptidase family M41; Region: Peptidase_M41; pfam01434
323097009996	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
323097009997	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
323097009998	Ligand Binding Site [chemical binding]; other site
323097009999	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
323097010000	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
323097010001	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323097010002	ligand binding site [chemical binding]; other site
323097010003	hypothetical protein; Provisional; Region: PRK14852
323097010004	PAS fold; Region: PAS_7; pfam12860
323097010005	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323097010006	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323097010007	metal binding site [ion binding]; metal-binding site
323097010008	active site
323097010009	I-site; other site
323097010010	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323097010011	translocation protein TolB; Provisional; Region: tolB; PRK05137
323097010012	TolB amino-terminal domain; Region: TolB_N; pfam04052
323097010013	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323097010014	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323097010015	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323097010016	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323097010017	TolA protein; Region: tolA_full; TIGR02794
323097010018	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
323097010019	TolR protein; Region: tolR; TIGR02801
323097010020	TolQ protein; Region: tolQ; TIGR02796
323097010021	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
323097010022	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323097010023	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323097010024	WHG domain; Region: WHG; pfam13305
323097010025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
323097010026	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097010027	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
323097010028	dimer interface [polypeptide binding]; other site
323097010029	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
323097010030	active site
323097010031	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
323097010032	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097010033	Walker A motif; other site
323097010034	ATP binding site [chemical binding]; other site
323097010035	Walker B motif; other site
323097010036	arginine finger; other site
323097010037	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
323097010038	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
323097010039	RuvA N terminal domain; Region: RuvA_N; pfam01330
323097010040	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
323097010041	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
323097010042	active site
323097010043	putative DNA-binding cleft [nucleotide binding]; other site
323097010044	dimer interface [polypeptide binding]; other site
323097010045	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
323097010046	MgtE intracellular N domain; Region: MgtE_N; pfam03448
323097010047	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
323097010048	Divalent cation transporter; Region: MgtE; pfam01769
323097010049	hypothetical protein; Validated; Region: PRK00110
323097010050	Protein of unknown function, DUF488; Region: DUF488; pfam04343
323097010051	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
323097010052	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323097010053	putative active site [active]
323097010054	metal binding site [ion binding]; metal-binding site
323097010055	homodimer binding site [polypeptide binding]; other site
323097010056	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
323097010057	Cell division protein ZapA; Region: ZapA; pfam05164
323097010058	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
323097010059	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
323097010060	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
323097010061	TPP-binding site [chemical binding]; other site
323097010062	dimer interface [polypeptide binding]; other site
323097010063	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
323097010064	PYR/PP interface [polypeptide binding]; other site
323097010065	dimer interface [polypeptide binding]; other site
323097010066	TPP binding site [chemical binding]; other site
323097010067	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
323097010068	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
323097010069	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
323097010070	Phosphoglycerate kinase; Region: PGK; pfam00162
323097010071	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
323097010072	substrate binding site [chemical binding]; other site
323097010073	hinge regions; other site
323097010074	ADP binding site [chemical binding]; other site
323097010075	catalytic site [active]
323097010076	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
323097010077	active site
323097010078	intersubunit interface [polypeptide binding]; other site
323097010079	catalytic residue [active]
323097010080	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
323097010081	active site
323097010082	pyrophosphate binding site [ion binding]; other site
323097010083	thiamine phosphate binding site [chemical binding]; other site
323097010084	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323097010085	Sel1-like repeats; Region: SEL1; smart00671
323097010086	Sel1-like repeats; Region: SEL1; smart00671
323097010087	Sel1-like repeats; Region: SEL1; smart00671
323097010088	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
323097010089	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
323097010090	active site
323097010091	dimerization interface [polypeptide binding]; other site
323097010092	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
323097010093	Protein export membrane protein; Region: SecD_SecF; cl14618
323097010094	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
323097010095	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323097010096	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097010097	hypothetical protein; Validated; Region: PRK09039
323097010098	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323097010099	ligand binding site [chemical binding]; other site
323097010100	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
323097010101	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323097010102	Coenzyme A binding pocket [chemical binding]; other site
323097010103	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
323097010104	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323097010105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097010106	Walker A/P-loop; other site
323097010107	ATP binding site [chemical binding]; other site
323097010108	Q-loop/lid; other site
323097010109	ABC transporter signature motif; other site
323097010110	Walker B; other site
323097010111	D-loop; other site
323097010112	H-loop/switch region; other site
323097010113	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
323097010114	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
323097010115	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
323097010116	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
323097010117	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
323097010118	NAD(P) binding site [chemical binding]; other site
323097010119	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
323097010120	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
323097010121	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
323097010122	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323097010123	PAS fold; Region: PAS_3; pfam08447
323097010124	putative active site [active]
323097010125	heme pocket [chemical binding]; other site
323097010126	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323097010127	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323097010128	metal binding site [ion binding]; metal-binding site
323097010129	active site
323097010130	I-site; other site
323097010131	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323097010132	hypothetical protein; Validated; Region: PRK00228
323097010133	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
323097010134	Transposase domain (DUF772); Region: DUF772; pfam05598
323097010135	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097010136	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097010137	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
323097010138	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
323097010139	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
323097010140	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
323097010141	NAD binding site [chemical binding]; other site
323097010142	homotetramer interface [polypeptide binding]; other site
323097010143	homodimer interface [polypeptide binding]; other site
323097010144	substrate binding site [chemical binding]; other site
323097010145	active site
323097010146	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
323097010147	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
323097010148	active site
323097010149	nucleophile elbow; other site
323097010150	Patatin phospholipase; Region: DUF3734; pfam12536
323097010151	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
323097010152	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
323097010153	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
323097010154	Walker A/P-loop; other site
323097010155	ATP binding site [chemical binding]; other site
323097010156	Q-loop/lid; other site
323097010157	ABC transporter signature motif; other site
323097010158	Walker B; other site
323097010159	D-loop; other site
323097010160	H-loop/switch region; other site
323097010161	TOBE-like domain; Region: TOBE_3; pfam12857
323097010162	sulfate transport protein; Provisional; Region: cysT; CHL00187
323097010163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097010164	dimer interface [polypeptide binding]; other site
323097010165	conserved gate region; other site
323097010166	putative PBP binding loops; other site
323097010167	ABC-ATPase subunit interface; other site
323097010168	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
323097010169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323097010170	dimer interface [polypeptide binding]; other site
323097010171	conserved gate region; other site
323097010172	putative PBP binding loops; other site
323097010173	ABC-ATPase subunit interface; other site
323097010174	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
323097010175	substrate binding pocket [chemical binding]; other site
323097010176	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
323097010177	membrane-bound complex binding site; other site
323097010178	hinge residues; other site
323097010179	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
323097010180	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
323097010181	Active Sites [active]
323097010182	siroheme synthase; Provisional; Region: cysG; PRK10637
323097010183	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
323097010184	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
323097010185	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
323097010186	active site
323097010187	SAM binding site [chemical binding]; other site
323097010188	homodimer interface [polypeptide binding]; other site
323097010189	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
323097010190	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
323097010191	Active Sites [active]
323097010192	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
323097010193	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
323097010194	CysD dimerization site [polypeptide binding]; other site
323097010195	G1 box; other site
323097010196	putative GEF interaction site [polypeptide binding]; other site
323097010197	GTP/Mg2+ binding site [chemical binding]; other site
323097010198	Switch I region; other site
323097010199	G2 box; other site
323097010200	G3 box; other site
323097010201	Switch II region; other site
323097010202	G4 box; other site
323097010203	G5 box; other site
323097010204	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
323097010205	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
323097010206	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
323097010207	ligand-binding site [chemical binding]; other site
323097010208	malate synthase G; Provisional; Region: PRK02999
323097010209	active site
323097010210	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
323097010211	two-component response regulator; Provisional; Region: PRK09191
323097010212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097010213	active site
323097010214	phosphorylation site [posttranslational modification]
323097010215	intermolecular recognition site; other site
323097010216	dimerization interface [polypeptide binding]; other site
323097010217	RNA polymerase sigma factor; Provisional; Region: PRK12540
323097010218	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323097010219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323097010220	DNA binding residues [nucleotide binding]
323097010221	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
323097010222	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097010223	HWE histidine kinase; Region: HWE_HK; pfam07536
323097010224	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
323097010225	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
323097010226	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097010227	FeS/SAM binding site; other site
323097010228	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
323097010229	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
323097010230	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
323097010231	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
323097010232	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
323097010233	Uncharacterized conserved protein [Function unknown]; Region: COG2968
323097010234	signal recognition particle protein; Provisional; Region: PRK10867
323097010235	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
323097010236	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
323097010237	P loop; other site
323097010238	GTP binding site [chemical binding]; other site
323097010239	Signal peptide binding domain; Region: SRP_SPB; pfam02978
323097010240	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
323097010241	RimM N-terminal domain; Region: RimM; pfam01782
323097010242	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
323097010243	PRC-barrel domain; Region: PRC; pfam05239
323097010244	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
323097010245	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
323097010246	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
323097010247	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
323097010248	substrate binding site [chemical binding]; other site
323097010249	ligand binding site [chemical binding]; other site
323097010250	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
323097010251	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
323097010252	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
323097010253	substrate binding site [chemical binding]; other site
323097010254	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
323097010255	active site clefts [active]
323097010256	zinc binding site [ion binding]; other site
323097010257	dimer interface [polypeptide binding]; other site
323097010258	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
323097010259	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
323097010260	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
323097010261	tartrate dehydrogenase; Region: TTC; TIGR02089
323097010262	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
323097010263	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
323097010264	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
323097010265	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
323097010266	E-class dimer interface [polypeptide binding]; other site
323097010267	P-class dimer interface [polypeptide binding]; other site
323097010268	active site
323097010269	Cu2+ binding site [ion binding]; other site
323097010270	Zn2+ binding site [ion binding]; other site
323097010271	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
323097010272	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
323097010273	Moco binding site; other site
323097010274	metal coordination site [ion binding]; other site
323097010275	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
323097010276	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
323097010277	malonyl-CoA synthase; Validated; Region: PRK07514
323097010278	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
323097010279	acyl-activating enzyme (AAE) consensus motif; other site
323097010280	active site
323097010281	AMP binding site [chemical binding]; other site
323097010282	CoA binding site [chemical binding]; other site
323097010283	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
323097010284	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
323097010285	Protein export membrane protein; Region: SecD_SecF; cl14618
323097010286	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
323097010287	Protein export membrane protein; Region: SecD_SecF; cl14618
323097010288	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323097010289	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323097010290	E3 interaction surface; other site
323097010291	lipoyl attachment site [posttranslational modification]; other site
323097010292	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097010293	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
323097010294	lipoyl-biotinyl attachment site [posttranslational modification]; other site
323097010295	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097010296	Caspase domain; Region: Peptidase_C14; pfam00656
323097010297	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
323097010298	AsmA family; Region: AsmA; pfam05170
323097010299	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
323097010300	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
323097010301	Protein export membrane protein; Region: SecD_SecF; cl14618
323097010302	HlyD family secretion protein; Region: HlyD_3; pfam13437
323097010303	benzoate transport; Region: 2A0115; TIGR00895
323097010304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097010305	putative substrate translocation pore; other site
323097010306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097010307	putative substrate translocation pore; other site
323097010308	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
323097010309	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
323097010310	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
323097010311	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
323097010312	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
323097010313	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
323097010314	active site
323097010315	homotetramer interface [polypeptide binding]; other site
323097010316	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
323097010317	Iron-sulfur protein interface; other site
323097010318	proximal quinone binding site [chemical binding]; other site
323097010319	SdhD (CybS) interface [polypeptide binding]; other site
323097010320	proximal heme binding site [chemical binding]; other site
323097010321	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
323097010322	putative SdhC subunit interface [polypeptide binding]; other site
323097010323	putative proximal heme binding site [chemical binding]; other site
323097010324	putative Iron-sulfur protein interface [polypeptide binding]; other site
323097010325	putative proximal quinone binding site; other site
323097010326	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
323097010327	L-aspartate oxidase; Provisional; Region: PRK06175
323097010328	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
323097010329	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
323097010330	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
323097010331	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
323097010332	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
323097010333	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323097010334	ligand binding site [chemical binding]; other site
323097010335	argininosuccinate synthase; Provisional; Region: PRK13820
323097010336	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
323097010337	ANP binding site [chemical binding]; other site
323097010338	Substrate Binding Site II [chemical binding]; other site
323097010339	Substrate Binding Site I [chemical binding]; other site
323097010340	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
323097010341	active site
323097010342	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
323097010343	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323097010344	FeS/SAM binding site; other site
323097010345	Uncharacterized conserved protein [Function unknown]; Region: COG3339
323097010346	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
323097010347	aromatic arch; other site
323097010348	DCoH dimer interaction site [polypeptide binding]; other site
323097010349	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
323097010350	DCoH tetramer interaction site [polypeptide binding]; other site
323097010351	substrate binding site [chemical binding]; other site
323097010352	Ferredoxin [Energy production and conversion]; Region: COG1146
323097010353	4Fe-4S binding domain; Region: Fer4; pfam00037
323097010354	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
323097010355	Uncharacterized conserved protein [Function unknown]; Region: COG3189
323097010356	heat shock protein 90; Provisional; Region: PRK05218
323097010357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097010358	ATP binding site [chemical binding]; other site
323097010359	Mg2+ binding site [ion binding]; other site
323097010360	G-X-G motif; other site
323097010361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
323097010362	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
323097010363	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
323097010364	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
323097010365	Transthyretin-like family; Region: DUF290; pfam01060
323097010366	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
323097010367	ApbE family; Region: ApbE; pfam02424
323097010368	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
323097010369	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323097010370	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097010371	N-terminal plug; other site
323097010372	ligand-binding site [chemical binding]; other site
323097010373	tonB-system energizer ExbB; Region: exbB; TIGR02797
323097010374	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323097010375	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
323097010376	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
323097010377	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
323097010378	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
323097010379	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323097010380	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
323097010381	Subunit I/III interface [polypeptide binding]; other site
323097010382	D-pathway; other site
323097010383	Subunit I/VIIc interface [polypeptide binding]; other site
323097010384	Subunit I/IV interface [polypeptide binding]; other site
323097010385	Subunit I/II interface [polypeptide binding]; other site
323097010386	Low-spin heme (heme a) binding site [chemical binding]; other site
323097010387	Subunit I/VIIa interface [polypeptide binding]; other site
323097010388	Subunit I/VIa interface [polypeptide binding]; other site
323097010389	Dimer interface; other site
323097010390	Putative water exit pathway; other site
323097010391	Binuclear center (heme a3/CuB) [ion binding]; other site
323097010392	K-pathway; other site
323097010393	Subunit I/Vb interface [polypeptide binding]; other site
323097010394	Putative proton exit pathway; other site
323097010395	Subunit I/VIb interface; other site
323097010396	Subunit I/VIc interface [polypeptide binding]; other site
323097010397	Electron transfer pathway; other site
323097010398	Subunit I/VIIIb interface [polypeptide binding]; other site
323097010399	Subunit I/VIIb interface [polypeptide binding]; other site
323097010400	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323097010401	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097010402	LysR substrate binding domain; Region: LysR_substrate; pfam03466
323097010403	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
323097010404	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
323097010405	putative ligand binding site [chemical binding]; other site
323097010406	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
323097010407	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
323097010408	TM-ABC transporter signature motif; other site
323097010409	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
323097010410	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
323097010411	TM-ABC transporter signature motif; other site
323097010412	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
323097010413	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
323097010414	Walker A/P-loop; other site
323097010415	ATP binding site [chemical binding]; other site
323097010416	Q-loop/lid; other site
323097010417	ABC transporter signature motif; other site
323097010418	Walker B; other site
323097010419	D-loop; other site
323097010420	H-loop/switch region; other site
323097010421	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
323097010422	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
323097010423	Walker A/P-loop; other site
323097010424	ATP binding site [chemical binding]; other site
323097010425	Q-loop/lid; other site
323097010426	ABC transporter signature motif; other site
323097010427	Walker B; other site
323097010428	D-loop; other site
323097010429	H-loop/switch region; other site
323097010430	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
323097010431	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
323097010432	FMN binding site [chemical binding]; other site
323097010433	active site
323097010434	catalytic residues [active]
323097010435	substrate binding site [chemical binding]; other site
323097010436	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
323097010437	PRC-barrel domain; Region: PRC; pfam05239
323097010438	Transposase domain (DUF772); Region: DUF772; pfam05598
323097010439	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097010440	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
323097010441	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
323097010442	Cupin domain; Region: Cupin_2; pfam07883
323097010443	Cupin domain; Region: Cupin_2; cl17218
323097010444	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323097010445	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323097010446	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
323097010447	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
323097010448	THF binding site; other site
323097010449	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
323097010450	substrate binding site [chemical binding]; other site
323097010451	THF binding site; other site
323097010452	zinc-binding site [ion binding]; other site
323097010453	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
323097010454	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
323097010455	ATP cone domain; Region: ATP-cone; pfam03477
323097010456	ATP cone domain; Region: ATP-cone; pfam03477
323097010457	Class I ribonucleotide reductase; Region: RNR_I; cd01679
323097010458	active site
323097010459	dimer interface [polypeptide binding]; other site
323097010460	catalytic residues [active]
323097010461	effector binding site; other site
323097010462	R2 peptide binding site; other site
323097010463	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
323097010464	dimer interface [polypeptide binding]; other site
323097010465	putative radical transfer pathway; other site
323097010466	diiron center [ion binding]; other site
323097010467	tyrosyl radical; other site
323097010468	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
323097010469	dimer interface [polypeptide binding]; other site
323097010470	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097010471	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
323097010472	MarR family; Region: MarR_2; pfam12802
323097010473	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
323097010474	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
323097010475	active site residue [active]
323097010476	Domain of unknown function (DUF336); Region: DUF336; cl01249
323097010477	DsrE/DsrF-like family; Region: DrsE; pfam02635
323097010478	DsrE/DsrF-like family; Region: DrsE; pfam02635
323097010479	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
323097010480	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
323097010481	active site
323097010482	metal binding site [ion binding]; metal-binding site
323097010483	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
323097010484	Cytochrome c [Energy production and conversion]; Region: COG3258
323097010485	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
323097010486	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
323097010487	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
323097010488	Protein of unknown function (DUF938); Region: DUF938; pfam06080
323097010489	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
323097010490	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323097010491	putative metal binding site [ion binding]; other site
323097010492	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
323097010493	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
323097010494	substrate binding pocket [chemical binding]; other site
323097010495	membrane-bound complex binding site; other site
323097010496	hinge residues; other site
323097010497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323097010498	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097010499	RNA polymerase sigma factor; Provisional; Region: PRK12515
323097010500	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323097010501	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323097010502	DNA binding residues [nucleotide binding]
323097010503	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097010504	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097010505	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097010506	osmolarity response regulator; Provisional; Region: ompR; PRK09468
323097010507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323097010508	active site
323097010509	phosphorylation site [posttranslational modification]
323097010510	intermolecular recognition site; other site
323097010511	dimerization interface [polypeptide binding]; other site
323097010512	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323097010513	DNA binding site [nucleotide binding]
323097010514	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323097010515	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
323097010516	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097010517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323097010518	dimer interface [polypeptide binding]; other site
323097010519	phosphorylation site [posttranslational modification]
323097010520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097010521	ATP binding site [chemical binding]; other site
323097010522	Mg2+ binding site [ion binding]; other site
323097010523	G-X-G motif; other site
323097010524	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
323097010525	dimerization interface [polypeptide binding]; other site
323097010526	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097010527	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097010528	ATP binding site [chemical binding]; other site
323097010529	Mg2+ binding site [ion binding]; other site
323097010530	G-X-G motif; other site
323097010531	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
323097010532	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
323097010533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
323097010534	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
323097010535	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
323097010536	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
323097010537	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
323097010538	NAD(P) binding site [chemical binding]; other site
323097010539	homotetramer interface [polypeptide binding]; other site
323097010540	homodimer interface [polypeptide binding]; other site
323097010541	active site
323097010542	EamA-like transporter family; Region: EamA; pfam00892
323097010543	muropeptide transporter; Validated; Region: ampG; cl17669
323097010544	muropeptide transporter; Reviewed; Region: ampG; PRK11902
323097010545	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
323097010546	active site
323097010547	catalytic residues [active]
323097010548	metal binding site [ion binding]; metal-binding site
323097010549	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
323097010550	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
323097010551	putative active site [active]
323097010552	substrate binding site [chemical binding]; other site
323097010553	putative cosubstrate binding site; other site
323097010554	catalytic site [active]
323097010555	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
323097010556	substrate binding site [chemical binding]; other site
323097010557	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
323097010558	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
323097010559	dimerization interface 3.5A [polypeptide binding]; other site
323097010560	active site
323097010561	nucleosidase; Provisional; Region: PRK05634
323097010562	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
323097010563	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
323097010564	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
323097010565	metal binding site [ion binding]; metal-binding site
323097010566	dimer interface [polypeptide binding]; other site
323097010567	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
323097010568	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
323097010569	trimer interface [polypeptide binding]; other site
323097010570	active site
323097010571	substrate binding site [chemical binding]; other site
323097010572	CoA binding site [chemical binding]; other site
323097010573	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
323097010574	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097010575	motif II; other site
323097010576	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
323097010577	feedback inhibition sensing region; other site
323097010578	homohexameric interface [polypeptide binding]; other site
323097010579	nucleotide binding site [chemical binding]; other site
323097010580	N-acetyl-L-glutamate binding site [chemical binding]; other site
323097010581	Protein of unknown function (DUF423); Region: DUF423; cl01008
323097010582	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
323097010583	G1 box; other site
323097010584	GTP/Mg2+ binding site [chemical binding]; other site
323097010585	Switch I region; other site
323097010586	G2 box; other site
323097010587	G3 box; other site
323097010588	Switch II region; other site
323097010589	G4 box; other site
323097010590	G5 box; other site
323097010591	membrane protein insertase; Provisional; Region: PRK01318
323097010592	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
323097010593	Ribonuclease P; Region: Ribonuclease_P; cl00457
323097010594	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
323097010595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097010596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097010597	ATP binding site [chemical binding]; other site
323097010598	Mg2+ binding site [ion binding]; other site
323097010599	G-X-G motif; other site
323097010600	AAA domain; Region: AAA_30; pfam13604
323097010601	Family description; Region: UvrD_C_2; pfam13538
323097010602	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
323097010603	putative Mg++ binding site [ion binding]; other site
323097010604	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323097010605	nucleotide binding region [chemical binding]; other site
323097010606	ATP-binding site [chemical binding]; other site
323097010607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097010608	ATP binding site [chemical binding]; other site
323097010609	Mg2+ binding site [ion binding]; other site
323097010610	G-X-G motif; other site
323097010611	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
323097010612	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
323097010613	active site
323097010614	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
323097010615	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323097010616	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
323097010617	Integrase core domain; Region: rve; pfam00665
323097010618	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
323097010619	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097010620	Walker A motif; other site
323097010621	ATP binding site [chemical binding]; other site
323097010622	Walker B motif; other site
323097010623	arginine finger; other site
323097010624	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
323097010625	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
323097010626	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323097010627	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323097010628	N-terminal plug; other site
323097010629	ligand-binding site [chemical binding]; other site
323097010630	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
323097010631	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
323097010632	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
323097010633	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
323097010634	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
323097010635	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
323097010636	active site
323097010637	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
323097010638	DNA binding residues [nucleotide binding]
323097010639	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
323097010640	dimer interface [polypeptide binding]; other site
323097010641	putative metal binding site [ion binding]; other site
323097010642	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
323097010643	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
323097010644	metal-binding site [ion binding]
323097010645	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323097010646	Soluble P-type ATPase [General function prediction only]; Region: COG4087
323097010647	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
323097010648	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
323097010649	intersubunit interface [polypeptide binding]; other site
323097010650	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
323097010651	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
323097010652	Walker A/P-loop; other site
323097010653	ATP binding site [chemical binding]; other site
323097010654	Q-loop/lid; other site
323097010655	ABC transporter signature motif; other site
323097010656	Walker B; other site
323097010657	D-loop; other site
323097010658	H-loop/switch region; other site
323097010659	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
323097010660	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
323097010661	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
323097010662	putative PBP binding regions; other site
323097010663	ABC-ATPase subunit  interface; other site
323097010664	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
323097010665	catalytic triad [active]
323097010666	dimer interface [polypeptide binding]; other site
323097010667	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
323097010668	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
323097010669	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
323097010670	acyl-activating enzyme (AAE) consensus motif; other site
323097010671	putative AMP binding site [chemical binding]; other site
323097010672	putative active site [active]
323097010673	putative CoA binding site [chemical binding]; other site
323097010674	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
323097010675	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
323097010676	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
323097010677	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323097010678	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097010679	Walker A/P-loop; other site
323097010680	ATP binding site [chemical binding]; other site
323097010681	Q-loop/lid; other site
323097010682	ABC transporter signature motif; other site
323097010683	Walker B; other site
323097010684	D-loop; other site
323097010685	H-loop/switch region; other site
323097010686	NMT1/THI5 like; Region: NMT1; pfam09084
323097010687	Predicted membrane protein [Function unknown]; Region: COG1238
323097010688	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
323097010689	RNA/DNA hybrid binding site [nucleotide binding]; other site
323097010690	active site
323097010691	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
323097010692	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
323097010693	putative active site [active]
323097010694	putative substrate binding site [chemical binding]; other site
323097010695	ATP binding site [chemical binding]; other site
323097010696	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
323097010697	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
323097010698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
323097010699	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
323097010700	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
323097010701	acyl-activating enzyme (AAE) consensus motif; other site
323097010702	putative AMP binding site [chemical binding]; other site
323097010703	putative active site [active]
323097010704	putative CoA binding site [chemical binding]; other site
323097010705	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
323097010706	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097010707	Walker A motif; other site
323097010708	ATP binding site [chemical binding]; other site
323097010709	Walker B motif; other site
323097010710	arginine finger; other site
323097010711	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
323097010712	multimerization interface [polypeptide binding]; other site
323097010713	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
323097010714	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
323097010715	homodimer interface [polypeptide binding]; other site
323097010716	active site
323097010717	heterodimer interface [polypeptide binding]; other site
323097010718	catalytic residue [active]
323097010719	metal binding site [ion binding]; metal-binding site
323097010720	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
323097010721	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
323097010722	intersubunit interface [polypeptide binding]; other site
323097010723	active site
323097010724	zinc binding site [ion binding]; other site
323097010725	Na+ binding site [ion binding]; other site
323097010726	phosphoribulokinase; Provisional; Region: PRK15453
323097010727	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
323097010728	metal binding site [ion binding]; metal-binding site
323097010729	active site
323097010730	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323097010731	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323097010732	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
323097010733	putative dimerization interface [polypeptide binding]; other site
323097010734	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323097010735	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323097010736	catalytic residue [active]
323097010737	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
323097010738	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
323097010739	putative active site [active]
323097010740	putative PHP Thumb interface [polypeptide binding]; other site
323097010741	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
323097010742	generic binding surface II; other site
323097010743	generic binding surface I; other site
323097010744	DNA Polymerase Y-family; Region: PolY_like; cd03468
323097010745	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
323097010746	DNA binding site [nucleotide binding]
323097010747	Uncharacterized conserved protein [Function unknown]; Region: COG4544
323097010748	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
323097010749	Part of AAA domain; Region: AAA_19; pfam13245
323097010750	Family description; Region: UvrD_C_2; pfam13538
323097010751	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097010752	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097010753	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097010754	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
323097010755	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
323097010756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323097010757	putative substrate translocation pore; other site
323097010758	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
323097010759	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
323097010760	active site
323097010761	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
323097010762	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323097010763	putative active site [active]
323097010764	putative metal binding site [ion binding]; other site
323097010765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
323097010766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
323097010767	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
323097010768	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
323097010769	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
323097010770	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323097010771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323097010772	ATP binding site [chemical binding]; other site
323097010773	Mg2+ binding site [ion binding]; other site
323097010774	G-X-G motif; other site
323097010775	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097010776	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097010777	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323097010778	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
323097010779	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
323097010780	RES domain; Region: RES; pfam08808
323097010781	PRC-barrel domain; Region: PRC; pfam05239
323097010782	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
323097010783	dinuclear metal binding motif [ion binding]; other site
323097010784	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
323097010785	MASE1; Region: MASE1; cl17823
323097010786	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097010787	HWE histidine kinase; Region: HWE_HK; smart00911
323097010788	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
323097010789	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323097010790	Transposase; Region: HTH_Tnp_1; pfam01527
323097010791	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
323097010792	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
323097010793	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
323097010794	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
323097010795	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
323097010796	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
323097010797	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
323097010798	BA14K-like protein; Region: BA14K; pfam07886
323097010799	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323097010800	putative active site [active]
323097010801	heme pocket [chemical binding]; other site
323097010802	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323097010803	HWE histidine kinase; Region: HWE_HK; cl06527
323097010804	Transposase; Region: HTH_Tnp_1; cl17663
323097010805	Helix-turn-helix domain; Region: HTH_28; pfam13518
323097010806	putative transposase OrfB; Reviewed; Region: PHA02517
323097010807	Homeodomain-like domain; Region: HTH_32; pfam13565
323097010808	Integrase core domain; Region: rve; pfam00665
323097010809	Integrase core domain; Region: rve_3; pfam13683
323097010810	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
323097010811	AAA domain; Region: AAA_23; pfam13476
323097010812	Family description; Region: UvrD_C_2; pfam13538
323097010813	Replication protein; Region: Rep_1; cl02412
323097010814	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
323097010815	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
323097010816	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323097010817	ABC transporter signature motif; other site
323097010818	Walker B; other site
323097010819	D-loop; other site
323097010820	H-loop/switch region; other site
323097010821	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
323097010822	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097010823	non-specific DNA binding site [nucleotide binding]; other site
323097010824	salt bridge; other site
323097010825	sequence-specific DNA binding site [nucleotide binding]; other site
323097010826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
323097010827	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
323097010828	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
323097010829	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
323097010830	multiple promoter invertase; Provisional; Region: mpi; PRK13413
323097010831	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
323097010832	catalytic residues [active]
323097010833	catalytic nucleophile [active]
323097010834	Presynaptic Site I dimer interface [polypeptide binding]; other site
323097010835	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
323097010836	Synaptic Flat tetramer interface [polypeptide binding]; other site
323097010837	Synaptic Site I dimer interface [polypeptide binding]; other site
323097010838	DNA binding site [nucleotide binding]
323097010839	Helix-turn-helix domain; Region: HTH_38; pfam13936
323097010840	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
323097010841	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
323097010842	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
323097010843	active site
323097010844	DNA binding site [nucleotide binding]
323097010845	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
323097010846	DNA binding site [nucleotide binding]
323097010847	PRC-barrel domain; Region: PRC; pfam05239
323097010848	Protein of unknown function, DUF488; Region: DUF488; pfam04343
323097010849	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
323097010850	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
323097010851	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097010852	active site
323097010853	DNA binding site [nucleotide binding]
323097010854	Int/Topo IB signature motif; other site
323097010855	ParA-like protein; Provisional; Region: PHA02518
323097010856	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323097010857	P-loop; other site
323097010858	Magnesium ion binding site [ion binding]; other site
323097010859	ParG; Region: ParG; pfam09274
323097010860	DnaA N-terminal domain; Region: DnaA_N; pfam11638
323097010861	Replication initiator protein A; Region: RPA; cl17860
323097010862	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097010863	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323097010864	catalytic residues [active]
323097010865	catalytic nucleophile [active]
323097010866	Recombinase; Region: Recombinase; pfam07508
323097010867	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323097010868	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
323097010869	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
323097010870	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
323097010871	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
323097010872	putative DNA binding site [nucleotide binding]; other site
323097010873	putative homodimer interface [polypeptide binding]; other site
323097010874	ATP-NAD kinase; Region: NAD_kinase; pfam01513
323097010875	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
323097010876	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
323097010877	Predicted membrane protein [Function unknown]; Region: COG2261
323097010878	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
323097010879	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
323097010880	GAF domain; Region: GAF; pfam01590
323097010881	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
323097010882	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
323097010883	putative active site [active]
323097010884	putative NTP binding site [chemical binding]; other site
323097010885	putative nucleic acid binding site [nucleotide binding]; other site
323097010886	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
323097010887	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097010888	Transposase domain (DUF772); Region: DUF772; pfam05598
323097010889	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
323097010890	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
323097010891	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
323097010892	Homeodomain-like domain; Region: HTH_23; pfam13384
323097010893	Winged helix-turn helix; Region: HTH_29; pfam13551
323097010894	Homeodomain-like domain; Region: HTH_32; pfam13565
323097010895	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097010896	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097010897	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
323097010898	active site
323097010899	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097010900	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097010901	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323097010902	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323097010903	catalytic residues [active]
323097010904	catalytic nucleophile [active]
323097010905	Recombinase; Region: Recombinase; pfam07508
323097010906	Helix-turn-helix domain; Region: HTH_17; pfam12728
323097010907	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
323097010908	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
323097010909	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
323097010910	active site
323097010911	DNA binding site [nucleotide binding]
323097010912	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
323097010913	DNA binding site [nucleotide binding]
323097010914	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
323097010915	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
323097010916	DNA binding site [nucleotide binding]
323097010917	heterodimer interface [polypeptide binding]; other site
323097010918	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
323097010919	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
323097010920	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
323097010921	active site
323097010922	DNA binding site [nucleotide binding]
323097010923	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
323097010924	DNA binding site [nucleotide binding]
323097010925	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
323097010926	nucleotide binding site [chemical binding]; other site
323097010927	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
323097010928	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
323097010929	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
323097010930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097010931	Walker A motif; other site
323097010932	ATP binding site [chemical binding]; other site
323097010933	Walker B motif; other site
323097010934	arginine finger; other site
323097010935	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
323097010936	DNA binding residues [nucleotide binding]
323097010937	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
323097010938	Integrase core domain; Region: rve; pfam00665
323097010939	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
323097010940	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323097010941	motif II; other site
323097010942	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
323097010943	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
323097010944	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
323097010945	iron-sulfur cluster [ion binding]; other site
323097010946	[2Fe-2S] cluster binding site [ion binding]; other site
323097010947	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
323097010948	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
323097010949	putative DNA binding site [nucleotide binding]; other site
323097010950	putative homodimer interface [polypeptide binding]; other site
323097010951	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
323097010952	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
323097010953	Integrase core domain; Region: rve; pfam00665
323097010954	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
323097010955	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323097010956	Walker A motif; other site
323097010957	ATP binding site [chemical binding]; other site
323097010958	Walker B motif; other site
323097010959	arginine finger; other site
323097010960	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
323097010961	PRC-barrel domain; Region: PRC; pfam05239
323097010962	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323097010963	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097010964	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097010965	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097010966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097010967	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097010968	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097010969	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
323097010970	Homeodomain-like domain; Region: HTH_23; cl17451
323097010971	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
323097010972	active site
323097010973	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097010974	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097010975	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097010976	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
323097010977	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
323097010978	Catalytic site; other site
323097010979	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
323097010980	Transposase; Region: HTH_Tnp_1; cl17663
323097010981	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323097010982	Low affinity iron permease; Region: Iron_permease; pfam04120
323097010983	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
323097010984	Uncharacterized conserved protein [Function unknown]; Region: COG3391
323097010985	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
323097010986	hypothetical protein; Provisional; Region: PRK12472
323097010987	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323097010988	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
323097010989	Helix-turn-helix domain; Region: HTH_28; pfam13518
323097010990	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
323097010991	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
323097010992	metal binding site [ion binding]; metal-binding site
323097010993	putative dimer interface [polypeptide binding]; other site
323097010994	Predicted membrane protein [Function unknown]; Region: COG2860
323097010995	UPF0126 domain; Region: UPF0126; pfam03458
323097010996	UPF0126 domain; Region: UPF0126; pfam03458
323097010997	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
323097010998	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
323097010999	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
323097011000	active site
323097011001	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
323097011002	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
323097011003	Predicted flavoprotein [General function prediction only]; Region: COG0431
323097011004	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
323097011005	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
323097011006	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
323097011007	putative active site [active]
323097011008	metal binding site [ion binding]; metal-binding site
323097011009	PRC-barrel domain; Region: PRC; pfam05239
323097011010	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
323097011011	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323097011012	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
323097011013	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
323097011014	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
323097011015	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
323097011016	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
323097011017	dimer interface [polypeptide binding]; other site
323097011018	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
323097011019	CheB methylesterase; Region: CheB_methylest; pfam01339
323097011020	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
323097011021	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
323097011022	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
323097011023	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
323097011024	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
323097011025	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
323097011026	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097011027	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323097011028	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097011029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097011030	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097011031	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323097011032	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323097011033	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323097011034	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
323097011035	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
323097011036	active site
323097011037	DNA binding site [nucleotide binding]
323097011038	Int/Topo IB signature motif; other site
323097011039	catalytic residues [active]
323097011040	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
323097011041	active site
323097011042	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
323097011043	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
323097011044	active site
323097011045	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097011046	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323097011047	active site
323097011048	DNA binding site [nucleotide binding]
323097011049	Int/Topo IB signature motif; other site
323097011050	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
323097011051	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
323097011052	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
323097011053	FAD binding domain; Region: FAD_binding_4; pfam01565
323097011054	Uncharacterized conserved protein [Function unknown]; Region: COG2135
323097011055	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323097011056	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323097011057	Winged helix-turn helix; Region: HTH_29; pfam13551
323097011058	Homeodomain-like domain; Region: HTH_23; cl17451
323097011059	Homeodomain-like domain; Region: HTH_32; pfam13565
323097011060	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
323097011061	nudix motif; other site
323097011062	TIGR02301 family protein; Region: TIGR02301
323097011063	dihydroorotase; Validated; Region: PRK09060
323097011064	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
323097011065	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
323097011066	active site
323097011067	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
323097011068	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
323097011069	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
323097011070	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
323097011071	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
323097011072	Peptidase C26; Region: Peptidase_C26; pfam07722
323097011073	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
323097011074	catalytic triad [active]
323097011075	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
323097011076	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
323097011077	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323097011078	non-specific DNA binding site [nucleotide binding]; other site
323097011079	salt bridge; other site
323097011080	sequence-specific DNA binding site [nucleotide binding]; other site
323097011081	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
323097011082	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
323097011083	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
323097011084	Fic/DOC family; Region: Fic; pfam02661
323097011085	Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828
323097011086	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
323097011087	Zn2+ binding site [ion binding]; other site
323097011088	Mg2+ binding site [ion binding]; other site
323097011089	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
323097011090	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
323097011091	SLBB domain; Region: SLBB; pfam10531
323097011092	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239